The reduced elastic modulus Er and indentation hardness HIT of various brittle solids including ceramics,semiconductors,glasses,single crystals,and laser material were evaluated using nanoindentation.Various analysis ...The reduced elastic modulus Er and indentation hardness HIT of various brittle solids including ceramics,semiconductors,glasses,single crystals,and laser material were evaluated using nanoindentation.Various analysis procedures were compared such as Oliver&Pharr and nominal hardness-based methods,which require area function of the indenter,and other methods based on energy,displacement,contact depth,and contact stiffness,which do not require calibration of the indenter.Elastic recovery of the imprint by the Knoop indenter was also utilized to evaluate elastic moduli of brittle solids.Expressions relating HIT/Er and dimensionless nanoindentation variables(e.g.,the ratio of elastic work over total work and the ratio of permanent displacement over maximum displacement)are found to be nonlinear rather than linear for brittle solids.The plastic hardness Hp of brittle solids(except traditional glasses)extracted based on Er is found to be proportional to E_(r)√H_(IT).展开更多
Achieving high-level integration of composite micro-nano structures with different structural characteristics through a minimalist and universal process has long been the goal pursued by advanced manufacturing researc...Achieving high-level integration of composite micro-nano structures with different structural characteristics through a minimalist and universal process has long been the goal pursued by advanced manufacturing research but is rarely explored due to the absence of instructive mechanisms.Here,we revealed a controllable ultrafast laser-induced focal volume light field and experimentally succeeded in highly efficient one-step composite structuring in multiple transparent solids.A pair of spatially coupled twin periodic structures reflecting light distribution in the focal volume are simultaneously created and independently tuned by engineering ultrafast laser-matter interaction.We demonstrated that the generated composite micro-nano structures are applicable to multi-dimensional information integration,nonlinear diffractive elements,and multi-functional optical modulation.This work presents the experimental verification of highly universal all-optical fabrication of composite micro-nano structures with independent controllability in multiple degrees of freedom,expands the current cognition of ultrafast laser-based material modification in transparent solids,and establishes a new scientific aspect of strong-field optics,namely,focal volume optics for composite structuring transparent solids.展开更多
We theoretically investigate the high-order harmonic generation(HHG)of defect-free solids by solving the timedependent Schrodinger equation(TDSE).The results show that the harmonic intensity can be enhanced,harmonic o...We theoretically investigate the high-order harmonic generation(HHG)of defect-free solids by solving the timedependent Schrodinger equation(TDSE).The results show that the harmonic intensity can be enhanced,harmonic order can be extended,and modulation near the cutoff order becomes smaller for the second plateau by increasing the time delay.These effects are due to an increase of the electron population in higher energy bands,where the larger band gap allows electrons to release more energy,and the long electronic paths are suppressed.Additionally,we also investigate the HHG of defective solids by Bohmian trajectories(BT).It is found that the harmonic intensity of the second plateau can be further enhanced.Simultaneously,cutoff order is also extended due to Bohmian particles moving farther away from the defective zone.展开更多
In this study,a straightforward one-step hydrothermal method was successfully utilized to synthesize the solid solution Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)-Na_(2)Ni_(2)Ti_(6)O_(16)(NNMTO-x),where x denotes the molar perce...In this study,a straightforward one-step hydrothermal method was successfully utilized to synthesize the solid solution Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)-Na_(2)Ni_(2)Ti_(6)O_(16)(NNMTO-x),where x denotes the molar percentage of Na_(2)Ni_(2)Ti_(6)O_(16)(NNTO)within Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)(NMTO),with x values of 10,20,30,40,and 50.Both XPS(X-ray Photoelectron Spectroscopy)and EDX(Energy Dispersive X-ray Spectroscopy)analyses unequivocally validated the formation of the NNMTO-x solid solutions.It was observed that when x is below 40,the NNMTO-x solid solution retains the structural characteristics of the original NMTO.However,beyond this threshold,significant alterations in crystal morphology were noted,accompanied by a noticeable decline in photocatalytic activity.Notably,the absorption edge of NNMTO-x(x<40)exhibited a shift towards the visible-light spectrum,thereby substantially broadening the absorption range.The findings highlight that NNMTO-30 possesses the most pronounced photocatalytic activity for the reduction of CO_(2).Specifically,after a 6 h irradiation period,the production rates of CO and CH_(4)were recorded at 42.38 and 1.47μmol/g,respectively.This investigation provides pivotal insights that are instrumental in the advancement of highly efficient and stable photocatalysts tailored for CO_(2)reduction processes.展开更多
Due to the high efficiency,no pollution,fuel flexibility and high temperature,solid oxide fuel cell(SOFC)is expected to be applied in aeronautical hybrid power system.In this paper,a 3D mesoscopic mod⁃el was establish...Due to the high efficiency,no pollution,fuel flexibility and high temperature,solid oxide fuel cell(SOFC)is expected to be applied in aeronautical hybrid power system.In this paper,a 3D mesoscopic mod⁃el was established for SOFC heterogeneous anode.The microstructure of Ni and gadolinium-doped ceria(GDC)anode was generated via Quartet Structure Generation Set(QSGS)method.The mesoscopic model of mass trans⁃fer,charge transfer and reacting flow was built based on lattice Boltzmann method(LBM).The simulation results agreed with the experimental data from reference under 650℃and 0.1 MPa.Meanwhile,the influence of leakage current on open circuit voltage cannot be ignored,which indicates the necessity of adding electron barrier layer.Higher inlet pressure was simulated in order to predict the performance under aeronautical conditions,which shows significant benefit for the performance.The reaction current density increases by 59%,107%and 147%for inlet pressure of 0.2 MPa,0.3 MPa and 0.4 MPa under polarization of 0.161 V.The reaction current shows a significant nonlinear distribution along the thickness direction,and the current density increases faster near the electrolyte.Under the same total polarization,the activation polarization decreases with the increase of inlet pres⁃sure,while the ohmic polarization is opposite.展开更多
Long-life pavement has been introduced to address the urgent need for durable and reliable transportation infrastructure.This review overviews the development of aggregates for long-life pavements and summarizes futur...Long-life pavement has been introduced to address the urgent need for durable and reliable transportation infrastructure.This review overviews the development of aggregates for long-life pavements and summarizes future research directions.The review indicates that natural aggregates,being non-renewable resources,are steadily declining in availability and may need to meet future demands.Construction solid waste aggregates are rapidly developing,with fine separation of reclaimed asphalt pavement(RAP)and reinforcement of cementbased recycled aggregates serving as key strategies to enhance their application.Industry solid waste aggregates possess properties suitable for long-life pavements and offer additional functionalities such as cooling,conductivity,and reflectivity,demonstrating significant development potential.While artificial aggregates exhibit superior performance,their large-scale application requires consideration of economic and environmental impacts.Current aggregate evaluation methods need to address the needs of long-life pavements.Aggregate performance requirements should be graded based on mechanical stress and temperature distribution,with corresponding evaluation methods and indices developed.Evaluating the mechanical properties of aggregates should align more closely with actual stress states.Tests such as triaxial,repeated load,and wheel abrasion polishing are better suited for assessing the strength and durability of long-life pavement aggregates.Similarly,evaluating aggregates'physicochemical properties should be based on studies correlating these properties with road performance,with proposed evaluation criteria.Morphological characteristics of aggregates significantly influence asphalt mixture performance,and efficient evaluation of their profile,angularity,and texture will be a key focus of future research.展开更多
Background:The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease.Transgenic approaches hold promise in addressing this com...Background:The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease.Transgenic approaches hold promise in addressing this complex problem.One such model,the Oncopig,has been reported to develop tumors of up to 4 cm in diameter within 7-14 days at sites of in situ vector inoculation.However,the resulting lesions reportedly contained an extensive inflammatory component that has not been evaluated in detail.Methods:Herein,we describe our results from multiparametric characterization of the lesions generated using liver biopsy cores incubated in vector solution and re-placed in the tissue.The study consisted of 3 animals in 3 cohorts(total of 9 animals)that were evaluated at 14,21,and 28 days.CT imaging,immunohistochemistry,multiplex immunofluorescence,and comprehensive blood analyses were used to quantify composition of the hepatic masses that developed following AdCre inoculation.Results:The tumors were hypovascular on CT and predominantly composed of CD45+cells with a strong lymphohistiocytic component,with no carcinomas identified.Ki-67 staining showed proliferation of CD45+immune cells but no neoplastic component.To provide further insight,the results are evaluated in the context of tumor growth kinetics.Conclusion:While progress has been made in generating targetable lesions,achieving a robust large animal model of liver cancer that faithfully recapitulates the human disease remains a challenging goal.展开更多
Halide solid-state electrolytes have gained significant attention in recent years due to their high ionic conductivity,making them promising candidates for future all-solid-state batteries.Recent studies have identifi...Halide solid-state electrolytes have gained significant attention in recent years due to their high ionic conductivity,making them promising candidates for future all-solid-state batteries.Recent studies have identified numerous crystal structures with the Li_(3)MX_(6)composition,although many remain unexplored across various chemical systems.In this research,we developed a comprehensive method to examine all conceivable space groups and structures within theLi-M-X system,where M includes In,Ga,and La,and X includes F,Cl,Br,and 1.Our findings revealed two metastable structures:Li_(3)InF_(6)with P3c1 symmetry and Li_(3)InI_(6)with C2/c symmetry,exhibiting ionic conductivities of 0.55 and 2.18mS/cm at 300K,respectively.Notably,the trigonal symmetry of Li3InF6 demonstrates that high ionic conductivities are not limited to monoclinic structures but can also be achieved with trigonal symmetries.The electrochemical stability windows,mechanical properties,and reaction energies of these materials with known cathodes suggest their potential for use in all-solid-state batteries.Additionally,we predicted the stability of novel materials,including Li_(5)InCl_(8),Li_(5)InBr_(8),Li_(5)InI_(8),LiIn_(2)Cl_(9),LiIn_(2)Br_(9),and LiIn_(2)I_(9).展开更多
This letter addresses challenges in the clinical translation of BIBR1532,a promising telomerase inhibitor,for the treatment of esophageal squamous cell carcinoma(ESCC).BIBR1532 exerts its anti-cancer effect by activat...This letter addresses challenges in the clinical translation of BIBR1532,a promising telomerase inhibitor,for the treatment of esophageal squamous cell carcinoma(ESCC).BIBR1532 exerts its anti-cancer effect by activating DNA damage response(ATR/CHK1 and ATM/CHK2)pathways and downregulating telomere-binding proteins.Although its therapeutic potential is limited by poor aqueous solubility,solid dispersion(SD)technology may overcome this obstacle.Systematic analysis using PubChem-derived simplified molecular input line entry system identifiers and artificial intelligence-driven FormulationDT platform evaluation(oral formulation feasibility index:0.38)revealed that the SD technology,with superior scalability(32 approved products by 2021)and lower production risks,outperforms lipid-based formulations as an optimal dissolution strategy.Material analysis revealed hydroxypropyl methylcellulose(HPMC)as the optimal carrier with lower hygroscopicity,higher temperature and no intestinal targeting,thus enabling ESCC therapy.HPMC-based SD enhances BIBR1532 solubility and bioavailability for effective ESCC treatment.Future studies should focus on pilot tests for SD fabrication.展开更多
Designing efficient,stable dual-functional combustion catalysts remains a key challenge in developing next-generation solid propellants,particularly in achieving wide pressure plateau combustion.Herein,we synthesize a...Designing efficient,stable dual-functional combustion catalysts remains a key challenge in developing next-generation solid propellants,particularly in achieving wide pressure plateau combustion.Herein,we synthesize a series of carbon dot-based catalysts(CDs-1,CDs-2,CDs/Cu)via oxidative etching and hydrothermal methods,and employ them to replace conventional carbon black(CB)at 0.65 wt%loading in the preparation of HMX-CMDB propellants.Systematic evaluation through combined thermochemical analysis(50–350℃),laser ignition diagnostics(50–350 W/cm^(2)),and combustion chamber testing(4–18 MPa)reveals remarkable catalytic enhancements.The optimized CDs/Cu catalyst demonstrates multifunctional superiority:(1)7.4℃ reduction in HMX-CMDB decomposition temperature at 10℃/min(from 205.2℃ to 196.0℃);(2)66.7%decrease in laser ignition delay(from 45 ms to 15 ms);(3)190.9%burning rate increase at 4 MPa(from 4.61 mm/s to 13.41 mm/s);(4)lower pressure exponent of 0.02 within 4–18 MPa range.Notably,CDs-1 induces stable"Plateau"combustion(4–14 MPa),while CDs/Cu achieves"Mesa"effects(8–12 MPa)via synergistic thermal feedback mechanisms-both phenomena ensure stable operation of the engine.Mechanistic studies integrate thermochemical kinetics,ignition combustion process,combustion flame structure,and combustion wave temperature distribution trends,which establish a new paradigm for the study of high efficiency combustion catalysts for solid propellants.展开更多
Dimethylphenols serve as important intermediates in synthesizing pharmaceuticals and agrochemicals,yet traditional distillation struggles to separate their isomers due to minimal boiling point differences,and the deve...Dimethylphenols serve as important intermediates in synthesizing pharmaceuticals and agrochemicals,yet traditional distillation struggles to separate their isomers due to minimal boiling point differences,and the development of melt crystallization is hampered by lacking solid–liquid equilibrium (SLE) data for some isomers.Therefore,the SLE data of both binary and ternary mixtures of 2,3-dimethylphenol (2,3-DMP),3,5-dimethylphenol (3,5-DMP),and 3,4-dimethylphenol (3,4-DMP) were determined by using differential scanning calorimetry in this work.Additionally,crystallographic analysis was conducted to investigate the thermodynamic characteristics of these mixtures.The experimental results indicated that all the systems investigated in this research exhibited eutectic behavior.The experimentally obtained SLE data were well correlated with the Wilson and non-random two-liquid models.The excess thermodynamic functions were calculated to analyze the types and intensities of the molecular interactions occurring in the mixtures.Furthermore,this study developed a model for the correlation between the theoretical crystallization yield and the actual cooling yield and final yield in melt crystallization.This study has furnished reliable data essential for developing and optimizing the melt crystallization process of mixtures of 2,3-DMP,3,5-DMP,and 3,4-DMP.展开更多
Cellulose,the most abundant and renewable biopolymer,offers a sustainable and cost-effective solution for regulating lithium electrodeposition toward safer lithium metal batteries,thanks to its high nanofibrous struct...Cellulose,the most abundant and renewable biopolymer,offers a sustainable and cost-effective solution for regulating lithium electrodeposition toward safer lithium metal batteries,thanks to its high nanofibrous structure and intrinsic lithiophilic property.In this work,we introduce interface-engineered cellulose-based separators by converting intrinsic hydroxyl groups on cellulose nanofibers(CNFs)to nitrogen functionalities through a trace conducting polymer coating.Both experimental and theoretical results reveal that the nitrogen moieties disrupt the compact hydrogen bond network within hydroxyl cellulose,enabling multiple nitrogen-lithium interactions that enhance lithium ion transport.In addition to an extraordinary Li^(+)transference number of 0.86 and a high ionic conductivity of 1.1 mS cm^(-1),the nitrogen-functionalized CNF contributes to a uniform electric field and Li^(+)concentration distribution across the lithium metal surface.This facilitates the formation of a LiF-rich solid electrolyte interface and suppresses Li dendrite growth.Consequently,Li‖Li cells demonstrate stable plating/stripping cycles for approximately 3000 h at a current density of 1 mA cm^(-2) with a fixed capacity of 1 mAh cm^(-2),while maintaining a low overpotential of 15 mV.Our work provides valuable insights into the surface functionalization of natural biomass for advancing sustainable energy storage technologies.展开更多
Arc faults within the transformers can generate sudden pressure surges,constituting significant hazards that may precipitate oil tank explosions and severely compromise power system stability.Conventional power−freque...Arc faults within the transformers can generate sudden pressure surges,constituting significant hazards that may precipitate oil tank explosions and severely compromise power system stability.Conventional power−frequency arc discharge experiments encounter limitations in isolating pressure wave characteristics due to persistent gas generation and arc reignition.To circumvent these challenges,an oil-immersed impulse voltage discharge platform was conceived and engineered to investigate pressure wave propagation dynamics.A pressure numerical simulation model and theoretical model of oil−solid interface reflection and refraction were subsequently established to elucidate the pressure propagation mechanism.The experimental and simulation results show that the pressure wave generated by pulsed arc discharge in oil propagates radially in the form of spherical waves.Due to the viscous loss and wave front expansion of transformer oil,the peak pressure decays exponentially with distance,with a decay coefficientβ=1.15.When pressure waves encounter metal obstacles inside transformer oil,there are two propagation paths:direct transmission through and multiple reflections through,and a mode transformation of pressure waves occurs at the oil−solid interface,mainly propagating through obstacles in the form of transverse waves.This work quantitatively delineates the energy pressure wave coupling,propagation dynamics,and attenuation mechanisms,providing critical insights for assessing and mitigating arc fault-induced transformer explosion risks.展开更多
Achieving high energy and power densities is currently a core challenge in the fabrication of energy storage materials.Although numerous high-capacity materials have been developed,conventional planar electrodes canno...Achieving high energy and power densities is currently a core challenge in the fabrication of energy storage materials.Although numerous high-capacity materials have been developed,conventional planar electrodes cannot achieve high active material loading and efficient ion/electron transport simultaneously.By contrast,three-dimensional(3D)structures have attracted increasing interest because of their capacity to enhance active material utilization,shorten ion and electron transport pathways,reduce interfacial impedance,and provide spatial accommodation for volume expansion.Additive manufacturing(AM)technology effectively fabricates energy-storage materials with 3D structures by accurately constructing complex 3D structures via layer-by-layer deposition.Recent studies have employed AM to construct ordered 3D electrodes that can optimize ion/electron transport,regulate electric field distribution,or improve the electrode-electrolyte interface,thereby contributing to enhanced kinetic performance and cycling stability.This review systematically summarizes the applications of several AM technologies in the fabrication of energy storage materials and analyzes their respective advantages and limitations.Subsequently,the advantages of AM technology in the fabrication of energy storage materials and several major optimization strategies are comprehensively discussed.Finally,the major challenges and potential applications of AM technology in energy storage material optimization are discussed.展开更多
To improve the solid–solid interface performance of all solid-state lithium batteries(ASSLBs),a novel sandwich-structured solid electrolyte(SSE,total thickness of 0.7 mm)was investigated.It comprises a central layer ...To improve the solid–solid interface performance of all solid-state lithium batteries(ASSLBs),a novel sandwich-structured solid electrolyte(SSE,total thickness of 0.7 mm)was investigated.It comprises a central layer of perovskite-type Li_(0.37)Sr_(0.44)Zr_(0.25)Ta_(0.75)O_(3)(LSZT)electrolyte(thickness of 0.5 mm)sandwiched between two layers of composite solid polymer electrolyte(CSPE,each with a thickness of 0.1 mm).The thin CSPE interlayer not only effectively reduces interfacial resistance between LSZT and electrodes,but also suppresses Li-induced reduction degradation of LSZT while ensuring uniform current density distribution across the interface.The SSE demonstrates an ionic conductivity of 8.76×10^(−5)S·cm^(−1)at 30℃,increasing to 1.13×10^(−3)S·cm^(−1)at 100℃,with an activation energy of 0.36 eV.In addition,SSE is stable for Li metal and achieves electrochemical stability up to 4.58 V vs.Li^(+)/Li.SSE shows outstanding electrode/electrolyte interfacial compatibility and significant suppression of the growth of Li dendrite.Ascribing to these merits,Li|SSE|Li symmetric cell maintained stable operation for 500 h at a current density of 0.3 mA·cm^(−2)without short circuit,confirming robust interfacial compatibility between SSE and Li electrode.The all-solid-state LiFePO_(4)|Li battery with SSE has an initial reversible discharge capacity of 109.8 mAh·g^(−1)and a reversible capacity of 118.1 mAh·g^(−1)after 50 cycles at a charge/discharge rate of 0.1C(30℃),demonstrating good cycling performance.展开更多
Polyethylene oxide(PEO)-based solid polymer electrolytes(SPEs)have long faced limitations due to low ionic conductivity at ambient temperature and poor interfacial stability with lithium metal anodes.Here,we present a...Polyethylene oxide(PEO)-based solid polymer electrolytes(SPEs)have long faced limitations due to low ionic conductivity at ambient temperature and poor interfacial stability with lithium metal anodes.Here,we present a structural engineering strategy to address these challenges through shear-induced crystallization of concentrated PEO-LiTFSI solutions,which self-assemble into flower-like spherulites with radially aligned lamellar crystals.This unique structure creates continuous Li^(+)transport highways through densely packed crystalline domains,achieving a record-high ionic conductivity of 1.70×10^(-4) S/cm at 25℃ for pristine PEO-based systems.Strategic incorporation of lithium montmorillonite(MMTli,10 wt%)further optimizes the composite electrolyte,balancing high ionic conductivity(1.47×10^(-4) S/cm)with enhanced electrochemical stability(4.99 V vs.Li^(+)/Li),elevated Li^(+)transference number(0.62),and mechanical robustness.The composite electrolyte enables stable Li plating/stripping over 800 h in symmetric Li||Li cells and powers LiFePO_(4)||Li solid-state batteries with 82%capacity retention after 200 cycles at 0.2 C under ambient conditions.This work pioneers a scalable processing paradigm for crystalline polymer electrolytes,offering new insights into ion transport mechanisms and validating clay minerals as multifunctional additives for next-generation energy storage systems.展开更多
Zn-Mn alloys are regarded as promising biodegradable metals for orthopedic applications owing to their moderate degradation rates and favorable osteogenic properties.However,the presence of a substantial number of sec...Zn-Mn alloys are regarded as promising biodegradable metals for orthopedic applications owing to their moderate degradation rates and favorable osteogenic properties.However,the presence of a substantial number of second-phase particles in Zn-based alloys might induce severe localized degradation via micro-coupling corrosion,thereby compromising the mechanical integrity of the alloy during in vivo tissue regeneration.In this study,high pressure solid solution(HPSS)treatment was conducted at 5 GPa and 380℃ for 1 h to fabricate Zn-0.5 Mn alloys.Microstructural characterization revealed that the HPSS treatment facilitated the formation of a supersaturated solid solution by completely dissolving theζ-MnZn_(13) phase into theα-Zn matrix.The resultant strengthening mechanisms,including supersaturated solid solution strengthening,grain-size strengthening,and dislocation strengthening,collectively enhanced the compressive yield strength(σ_(cys))of the Zn-0.5 Mn alloy to about 183.7 MPa,approximately three times that of the as-cast(AC)Zn-0.5 Mn alloy.Moreover,compared with the AC alloy,the HPSS Zn-0.5 Mn alloy exhibited uniform degradation behavior with a markedly reduced degradation rate.展开更多
Artificial intelligence(AI)is increasingly recognized as a transformative force in the field of solid organ transplantation.From enhancing donor-recipient matching to predicting clinical risks and tailoring immunosupp...Artificial intelligence(AI)is increasingly recognized as a transformative force in the field of solid organ transplantation.From enhancing donor-recipient matching to predicting clinical risks and tailoring immunosuppressive therapy,AI has the potential to improve both operational efficiency and patient outcomes.Despite these advancements,the perspectives of transplant professionals-those at the forefront of critical decision-making-remain insufficiently explored.To address this gap,this study utilizes a multi-round electronic Delphi approach to gather and analyses insights from global experts involved in organ transplantation.Participants are invited to complete structured surveys capturing demographic data,professional roles,institutional practices,and prior exposure to AI technologies.The survey also explores perceptions of AI’s potential benefits.Quantitative responses are analyzed using descriptive statistics,while open-ended qualitative responses undergo thematic analysis.Preliminary findings indicate a generally positive outlook on AI’s role in enhancing transplantation processes,particularly in areas such as donor matching and post-operative care.These mixed views reflect both optimism and caution among professionals tasked with integrating new technologies into high-stakes clinical workflows.By capturing a wide range of expert opinions,the findings will inform future policy development,regulatory considerations,and institutional readiness frameworks for the integration of AI into organ transplantation.展开更多
基金supported by the National Natural Science Foundation of China (Grant No.51705082)Fujian Provincial Minjiang Scholar Program (Grant No.0020-510759)+1 种基金Qishan Sholar program in Fuzhou University (Grant No.0020-650289)Fuzhou University Testing Fund of precious apparatus (Grant No.2023T018).
文摘The reduced elastic modulus Er and indentation hardness HIT of various brittle solids including ceramics,semiconductors,glasses,single crystals,and laser material were evaluated using nanoindentation.Various analysis procedures were compared such as Oliver&Pharr and nominal hardness-based methods,which require area function of the indenter,and other methods based on energy,displacement,contact depth,and contact stiffness,which do not require calibration of the indenter.Elastic recovery of the imprint by the Knoop indenter was also utilized to evaluate elastic moduli of brittle solids.Expressions relating HIT/Er and dimensionless nanoindentation variables(e.g.,the ratio of elastic work over total work and the ratio of permanent displacement over maximum displacement)are found to be nonlinear rather than linear for brittle solids.The plastic hardness Hp of brittle solids(except traditional glasses)extracted based on Er is found to be proportional to E_(r)√H_(IT).
基金financially supported by the National Key Research and Development Program of China(No.2021YFB2802001)the National Natural Science Foundation of China(Grant Nos.12304349,U20A20211,62275233)the Postdoctoral Fellowship Program of CPSF(GZB20230628,GZC20241465)。
文摘Achieving high-level integration of composite micro-nano structures with different structural characteristics through a minimalist and universal process has long been the goal pursued by advanced manufacturing research but is rarely explored due to the absence of instructive mechanisms.Here,we revealed a controllable ultrafast laser-induced focal volume light field and experimentally succeeded in highly efficient one-step composite structuring in multiple transparent solids.A pair of spatially coupled twin periodic structures reflecting light distribution in the focal volume are simultaneously created and independently tuned by engineering ultrafast laser-matter interaction.We demonstrated that the generated composite micro-nano structures are applicable to multi-dimensional information integration,nonlinear diffractive elements,and multi-functional optical modulation.This work presents the experimental verification of highly universal all-optical fabrication of composite micro-nano structures with independent controllability in multiple degrees of freedom,expands the current cognition of ultrafast laser-based material modification in transparent solids,and establishes a new scientific aspect of strong-field optics,namely,focal volume optics for composite structuring transparent solids.
基金supported by the Natural Science Foundation of Jilin Province of China(Grant No.20230101014JC)the Fundamental Research Funds for the Central Universities(Grant No.2572021BC05)the National Natural Science Foundation of China(Grant No.12374265)。
文摘We theoretically investigate the high-order harmonic generation(HHG)of defect-free solids by solving the timedependent Schrodinger equation(TDSE).The results show that the harmonic intensity can be enhanced,harmonic order can be extended,and modulation near the cutoff order becomes smaller for the second plateau by increasing the time delay.These effects are due to an increase of the electron population in higher energy bands,where the larger band gap allows electrons to release more energy,and the long electronic paths are suppressed.Additionally,we also investigate the HHG of defective solids by Bohmian trajectories(BT).It is found that the harmonic intensity of the second plateau can be further enhanced.Simultaneously,cutoff order is also extended due to Bohmian particles moving farther away from the defective zone.
基金Supported by the Doctoral Research Start-up Project of Yuncheng University(YQ-2023067)Project of Shanxi Natural Science Foundation(202303021211189)+1 种基金Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Provinces(20220036)Shanxi ProvinceIntelligent Optoelectronic Sensing Application Technology Innovation Center and Shanxi Province Optoelectronic Information Science and TechnologyLaboratory,Yuncheng University.
文摘In this study,a straightforward one-step hydrothermal method was successfully utilized to synthesize the solid solution Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)-Na_(2)Ni_(2)Ti_(6)O_(16)(NNMTO-x),where x denotes the molar percentage of Na_(2)Ni_(2)Ti_(6)O_(16)(NNTO)within Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)(NMTO),with x values of 10,20,30,40,and 50.Both XPS(X-ray Photoelectron Spectroscopy)and EDX(Energy Dispersive X-ray Spectroscopy)analyses unequivocally validated the formation of the NNMTO-x solid solutions.It was observed that when x is below 40,the NNMTO-x solid solution retains the structural characteristics of the original NMTO.However,beyond this threshold,significant alterations in crystal morphology were noted,accompanied by a noticeable decline in photocatalytic activity.Notably,the absorption edge of NNMTO-x(x<40)exhibited a shift towards the visible-light spectrum,thereby substantially broadening the absorption range.The findings highlight that NNMTO-30 possesses the most pronounced photocatalytic activity for the reduction of CO_(2).Specifically,after a 6 h irradiation period,the production rates of CO and CH_(4)were recorded at 42.38 and 1.47μmol/g,respectively.This investigation provides pivotal insights that are instrumental in the advancement of highly efficient and stable photocatalysts tailored for CO_(2)reduction processes.
文摘Due to the high efficiency,no pollution,fuel flexibility and high temperature,solid oxide fuel cell(SOFC)is expected to be applied in aeronautical hybrid power system.In this paper,a 3D mesoscopic mod⁃el was established for SOFC heterogeneous anode.The microstructure of Ni and gadolinium-doped ceria(GDC)anode was generated via Quartet Structure Generation Set(QSGS)method.The mesoscopic model of mass trans⁃fer,charge transfer and reacting flow was built based on lattice Boltzmann method(LBM).The simulation results agreed with the experimental data from reference under 650℃and 0.1 MPa.Meanwhile,the influence of leakage current on open circuit voltage cannot be ignored,which indicates the necessity of adding electron barrier layer.Higher inlet pressure was simulated in order to predict the performance under aeronautical conditions,which shows significant benefit for the performance.The reaction current density increases by 59%,107%and 147%for inlet pressure of 0.2 MPa,0.3 MPa and 0.4 MPa under polarization of 0.161 V.The reaction current shows a significant nonlinear distribution along the thickness direction,and the current density increases faster near the electrolyte.Under the same total polarization,the activation polarization decreases with the increase of inlet pres⁃sure,while the ohmic polarization is opposite.
基金sponsored by the National Natural Science Foundation of China(52178420,52408476)Research Project of Liaoning Provincial Transportation Construction Investment Group Co.,Ltd.(202410)+1 种基金Postdoctoral Fellowship Program of CPSF(GZC20242207)the Fundamental Research Funds for the Central Universities(HIT.DZJJ.2023086).
文摘Long-life pavement has been introduced to address the urgent need for durable and reliable transportation infrastructure.This review overviews the development of aggregates for long-life pavements and summarizes future research directions.The review indicates that natural aggregates,being non-renewable resources,are steadily declining in availability and may need to meet future demands.Construction solid waste aggregates are rapidly developing,with fine separation of reclaimed asphalt pavement(RAP)and reinforcement of cementbased recycled aggregates serving as key strategies to enhance their application.Industry solid waste aggregates possess properties suitable for long-life pavements and offer additional functionalities such as cooling,conductivity,and reflectivity,demonstrating significant development potential.While artificial aggregates exhibit superior performance,their large-scale application requires consideration of economic and environmental impacts.Current aggregate evaluation methods need to address the needs of long-life pavements.Aggregate performance requirements should be graded based on mechanical stress and temperature distribution,with corresponding evaluation methods and indices developed.Evaluating the mechanical properties of aggregates should align more closely with actual stress states.Tests such as triaxial,repeated load,and wheel abrasion polishing are better suited for assessing the strength and durability of long-life pavement aggregates.Similarly,evaluating aggregates'physicochemical properties should be based on studies correlating these properties with road performance,with proposed evaluation criteria.Morphological characteristics of aggregates significantly influence asphalt mixture performance,and efficient evaluation of their profile,angularity,and texture will be a key focus of future research.
基金Institutional Research Grant,MD Anderson Cancer CenterUPWARDS Training Program(Undergraduate Students Working Towards Research in Science),Grant/Award Number:1R25CA240137-01A1the CPRIT Research Training Award CPRIT Training Program,Grant/Award Number:RP210028。
文摘Background:The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease.Transgenic approaches hold promise in addressing this complex problem.One such model,the Oncopig,has been reported to develop tumors of up to 4 cm in diameter within 7-14 days at sites of in situ vector inoculation.However,the resulting lesions reportedly contained an extensive inflammatory component that has not been evaluated in detail.Methods:Herein,we describe our results from multiparametric characterization of the lesions generated using liver biopsy cores incubated in vector solution and re-placed in the tissue.The study consisted of 3 animals in 3 cohorts(total of 9 animals)that were evaluated at 14,21,and 28 days.CT imaging,immunohistochemistry,multiplex immunofluorescence,and comprehensive blood analyses were used to quantify composition of the hepatic masses that developed following AdCre inoculation.Results:The tumors were hypovascular on CT and predominantly composed of CD45+cells with a strong lymphohistiocytic component,with no carcinomas identified.Ki-67 staining showed proliferation of CD45+immune cells but no neoplastic component.To provide further insight,the results are evaluated in the context of tumor growth kinetics.Conclusion:While progress has been made in generating targetable lesions,achieving a robust large animal model of liver cancer that faithfully recapitulates the human disease remains a challenging goal.
基金supported by the Higher Education and Science Committee of Armenia in the frames of the research projects 20TTSG-2F010, 23AA-2F033 and ANSEF (EN-matsc-2660) grant.
文摘Halide solid-state electrolytes have gained significant attention in recent years due to their high ionic conductivity,making them promising candidates for future all-solid-state batteries.Recent studies have identified numerous crystal structures with the Li_(3)MX_(6)composition,although many remain unexplored across various chemical systems.In this research,we developed a comprehensive method to examine all conceivable space groups and structures within theLi-M-X system,where M includes In,Ga,and La,and X includes F,Cl,Br,and 1.Our findings revealed two metastable structures:Li_(3)InF_(6)with P3c1 symmetry and Li_(3)InI_(6)with C2/c symmetry,exhibiting ionic conductivities of 0.55 and 2.18mS/cm at 300K,respectively.Notably,the trigonal symmetry of Li3InF6 demonstrates that high ionic conductivities are not limited to monoclinic structures but can also be achieved with trigonal symmetries.The electrochemical stability windows,mechanical properties,and reaction energies of these materials with known cathodes suggest their potential for use in all-solid-state batteries.Additionally,we predicted the stability of novel materials,including Li_(5)InCl_(8),Li_(5)InBr_(8),Li_(5)InI_(8),LiIn_(2)Cl_(9),LiIn_(2)Br_(9),and LiIn_(2)I_(9).
基金Supported by“Continuation”Project of Excellent Doctors,Guangdong Basic and Applied Basic Research Foundation,No.2025A04J5082Guangdong Basic and Applied Basic Research Foundation,No.2024A1515011236.
文摘This letter addresses challenges in the clinical translation of BIBR1532,a promising telomerase inhibitor,for the treatment of esophageal squamous cell carcinoma(ESCC).BIBR1532 exerts its anti-cancer effect by activating DNA damage response(ATR/CHK1 and ATM/CHK2)pathways and downregulating telomere-binding proteins.Although its therapeutic potential is limited by poor aqueous solubility,solid dispersion(SD)technology may overcome this obstacle.Systematic analysis using PubChem-derived simplified molecular input line entry system identifiers and artificial intelligence-driven FormulationDT platform evaluation(oral formulation feasibility index:0.38)revealed that the SD technology,with superior scalability(32 approved products by 2021)and lower production risks,outperforms lipid-based formulations as an optimal dissolution strategy.Material analysis revealed hydroxypropyl methylcellulose(HPMC)as the optimal carrier with lower hygroscopicity,higher temperature and no intestinal targeting,thus enabling ESCC therapy.HPMC-based SD enhances BIBR1532 solubility and bioavailability for effective ESCC treatment.Future studies should focus on pilot tests for SD fabrication.
基金supported by the National Natural Science Foundation of China(Grant No.22205178).
文摘Designing efficient,stable dual-functional combustion catalysts remains a key challenge in developing next-generation solid propellants,particularly in achieving wide pressure plateau combustion.Herein,we synthesize a series of carbon dot-based catalysts(CDs-1,CDs-2,CDs/Cu)via oxidative etching and hydrothermal methods,and employ them to replace conventional carbon black(CB)at 0.65 wt%loading in the preparation of HMX-CMDB propellants.Systematic evaluation through combined thermochemical analysis(50–350℃),laser ignition diagnostics(50–350 W/cm^(2)),and combustion chamber testing(4–18 MPa)reveals remarkable catalytic enhancements.The optimized CDs/Cu catalyst demonstrates multifunctional superiority:(1)7.4℃ reduction in HMX-CMDB decomposition temperature at 10℃/min(from 205.2℃ to 196.0℃);(2)66.7%decrease in laser ignition delay(from 45 ms to 15 ms);(3)190.9%burning rate increase at 4 MPa(from 4.61 mm/s to 13.41 mm/s);(4)lower pressure exponent of 0.02 within 4–18 MPa range.Notably,CDs-1 induces stable"Plateau"combustion(4–14 MPa),while CDs/Cu achieves"Mesa"effects(8–12 MPa)via synergistic thermal feedback mechanisms-both phenomena ensure stable operation of the engine.Mechanistic studies integrate thermochemical kinetics,ignition combustion process,combustion flame structure,and combustion wave temperature distribution trends,which establish a new paradigm for the study of high efficiency combustion catalysts for solid propellants.
基金funded by the National Natural Science Foundation of China(22308358,22208346,22421003)IPE Project for Frontier Basic Research(QYJC-2023-05)CAS Project for Young Scientists in Basic Research(YSBR-038).
文摘Dimethylphenols serve as important intermediates in synthesizing pharmaceuticals and agrochemicals,yet traditional distillation struggles to separate their isomers due to minimal boiling point differences,and the development of melt crystallization is hampered by lacking solid–liquid equilibrium (SLE) data for some isomers.Therefore,the SLE data of both binary and ternary mixtures of 2,3-dimethylphenol (2,3-DMP),3,5-dimethylphenol (3,5-DMP),and 3,4-dimethylphenol (3,4-DMP) were determined by using differential scanning calorimetry in this work.Additionally,crystallographic analysis was conducted to investigate the thermodynamic characteristics of these mixtures.The experimental results indicated that all the systems investigated in this research exhibited eutectic behavior.The experimentally obtained SLE data were well correlated with the Wilson and non-random two-liquid models.The excess thermodynamic functions were calculated to analyze the types and intensities of the molecular interactions occurring in the mixtures.Furthermore,this study developed a model for the correlation between the theoretical crystallization yield and the actual cooling yield and final yield in melt crystallization.This study has furnished reliable data essential for developing and optimizing the melt crystallization process of mixtures of 2,3-DMP,3,5-DMP,and 3,4-DMP.
基金supported by the National Natural Science Foundation of China(Grant No.22479046,22461142135)。
文摘Cellulose,the most abundant and renewable biopolymer,offers a sustainable and cost-effective solution for regulating lithium electrodeposition toward safer lithium metal batteries,thanks to its high nanofibrous structure and intrinsic lithiophilic property.In this work,we introduce interface-engineered cellulose-based separators by converting intrinsic hydroxyl groups on cellulose nanofibers(CNFs)to nitrogen functionalities through a trace conducting polymer coating.Both experimental and theoretical results reveal that the nitrogen moieties disrupt the compact hydrogen bond network within hydroxyl cellulose,enabling multiple nitrogen-lithium interactions that enhance lithium ion transport.In addition to an extraordinary Li^(+)transference number of 0.86 and a high ionic conductivity of 1.1 mS cm^(-1),the nitrogen-functionalized CNF contributes to a uniform electric field and Li^(+)concentration distribution across the lithium metal surface.This facilitates the formation of a LiF-rich solid electrolyte interface and suppresses Li dendrite growth.Consequently,Li‖Li cells demonstrate stable plating/stripping cycles for approximately 3000 h at a current density of 1 mA cm^(-2) with a fixed capacity of 1 mAh cm^(-2),while maintaining a low overpotential of 15 mV.Our work provides valuable insights into the surface functionalization of natural biomass for advancing sustainable energy storage technologies.
基金funded by the Science and Technology Program of State Grid Corporation of China(5500-202356358A-2-1-ZX).
文摘Arc faults within the transformers can generate sudden pressure surges,constituting significant hazards that may precipitate oil tank explosions and severely compromise power system stability.Conventional power−frequency arc discharge experiments encounter limitations in isolating pressure wave characteristics due to persistent gas generation and arc reignition.To circumvent these challenges,an oil-immersed impulse voltage discharge platform was conceived and engineered to investigate pressure wave propagation dynamics.A pressure numerical simulation model and theoretical model of oil−solid interface reflection and refraction were subsequently established to elucidate the pressure propagation mechanism.The experimental and simulation results show that the pressure wave generated by pulsed arc discharge in oil propagates radially in the form of spherical waves.Due to the viscous loss and wave front expansion of transformer oil,the peak pressure decays exponentially with distance,with a decay coefficientβ=1.15.When pressure waves encounter metal obstacles inside transformer oil,there are two propagation paths:direct transmission through and multiple reflections through,and a mode transformation of pressure waves occurs at the oil−solid interface,mainly propagating through obstacles in the form of transverse waves.This work quantitatively delineates the energy pressure wave coupling,propagation dynamics,and attenuation mechanisms,providing critical insights for assessing and mitigating arc fault-induced transformer explosion risks.
基金support of the National Natural Science Foundation of China(No.52574411)Beijing Natural Science Foundation(No.2242043).
文摘Achieving high energy and power densities is currently a core challenge in the fabrication of energy storage materials.Although numerous high-capacity materials have been developed,conventional planar electrodes cannot achieve high active material loading and efficient ion/electron transport simultaneously.By contrast,three-dimensional(3D)structures have attracted increasing interest because of their capacity to enhance active material utilization,shorten ion and electron transport pathways,reduce interfacial impedance,and provide spatial accommodation for volume expansion.Additive manufacturing(AM)technology effectively fabricates energy-storage materials with 3D structures by accurately constructing complex 3D structures via layer-by-layer deposition.Recent studies have employed AM to construct ordered 3D electrodes that can optimize ion/electron transport,regulate electric field distribution,or improve the electrode-electrolyte interface,thereby contributing to enhanced kinetic performance and cycling stability.This review systematically summarizes the applications of several AM technologies in the fabrication of energy storage materials and analyzes their respective advantages and limitations.Subsequently,the advantages of AM technology in the fabrication of energy storage materials and several major optimization strategies are comprehensively discussed.Finally,the major challenges and potential applications of AM technology in energy storage material optimization are discussed.
基金financial support providedby the National Natural Science Foundation of China (Nos.92475203 and 52474374)the Joint Fund of Henan Province Science and Technology R&D Program,China (No.225200810035)the Research Initiation Grant for High-Level Talents by the Henan Academy of Sciences,China(No.232007016).
文摘To improve the solid–solid interface performance of all solid-state lithium batteries(ASSLBs),a novel sandwich-structured solid electrolyte(SSE,total thickness of 0.7 mm)was investigated.It comprises a central layer of perovskite-type Li_(0.37)Sr_(0.44)Zr_(0.25)Ta_(0.75)O_(3)(LSZT)electrolyte(thickness of 0.5 mm)sandwiched between two layers of composite solid polymer electrolyte(CSPE,each with a thickness of 0.1 mm).The thin CSPE interlayer not only effectively reduces interfacial resistance between LSZT and electrodes,but also suppresses Li-induced reduction degradation of LSZT while ensuring uniform current density distribution across the interface.The SSE demonstrates an ionic conductivity of 8.76×10^(−5)S·cm^(−1)at 30℃,increasing to 1.13×10^(−3)S·cm^(−1)at 100℃,with an activation energy of 0.36 eV.In addition,SSE is stable for Li metal and achieves electrochemical stability up to 4.58 V vs.Li^(+)/Li.SSE shows outstanding electrode/electrolyte interfacial compatibility and significant suppression of the growth of Li dendrite.Ascribing to these merits,Li|SSE|Li symmetric cell maintained stable operation for 500 h at a current density of 0.3 mA·cm^(−2)without short circuit,confirming robust interfacial compatibility between SSE and Li electrode.The all-solid-state LiFePO_(4)|Li battery with SSE has an initial reversible discharge capacity of 109.8 mAh·g^(−1)and a reversible capacity of 118.1 mAh·g^(−1)after 50 cycles at a charge/discharge rate of 0.1C(30℃),demonstrating good cycling performance.
基金supported by the National Natural Science Foundation of China(No.42272044)the High-performance Computing Platform of China University of Geosciences Beijing。
文摘Polyethylene oxide(PEO)-based solid polymer electrolytes(SPEs)have long faced limitations due to low ionic conductivity at ambient temperature and poor interfacial stability with lithium metal anodes.Here,we present a structural engineering strategy to address these challenges through shear-induced crystallization of concentrated PEO-LiTFSI solutions,which self-assemble into flower-like spherulites with radially aligned lamellar crystals.This unique structure creates continuous Li^(+)transport highways through densely packed crystalline domains,achieving a record-high ionic conductivity of 1.70×10^(-4) S/cm at 25℃ for pristine PEO-based systems.Strategic incorporation of lithium montmorillonite(MMTli,10 wt%)further optimizes the composite electrolyte,balancing high ionic conductivity(1.47×10^(-4) S/cm)with enhanced electrochemical stability(4.99 V vs.Li^(+)/Li),elevated Li^(+)transference number(0.62),and mechanical robustness.The composite electrolyte enables stable Li plating/stripping over 800 h in symmetric Li||Li cells and powers LiFePO_(4)||Li solid-state batteries with 82%capacity retention after 200 cycles at 0.2 C under ambient conditions.This work pioneers a scalable processing paradigm for crystalline polymer electrolytes,offering new insights into ion transport mechanisms and validating clay minerals as multifunctional additives for next-generation energy storage systems.
基金Project(52401064)supported by the National Natural Science Foundation of ChinaProject(24B0172)supported by the Scientific Research Fund of Hunan Provincial Education Department,ChinaProject(XDCX2024Y273)supported by the Postgraduate Scientific Research Innovation Project of Xiangtan University,China。
文摘Zn-Mn alloys are regarded as promising biodegradable metals for orthopedic applications owing to their moderate degradation rates and favorable osteogenic properties.However,the presence of a substantial number of second-phase particles in Zn-based alloys might induce severe localized degradation via micro-coupling corrosion,thereby compromising the mechanical integrity of the alloy during in vivo tissue regeneration.In this study,high pressure solid solution(HPSS)treatment was conducted at 5 GPa and 380℃ for 1 h to fabricate Zn-0.5 Mn alloys.Microstructural characterization revealed that the HPSS treatment facilitated the formation of a supersaturated solid solution by completely dissolving theζ-MnZn_(13) phase into theα-Zn matrix.The resultant strengthening mechanisms,including supersaturated solid solution strengthening,grain-size strengthening,and dislocation strengthening,collectively enhanced the compressive yield strength(σ_(cys))of the Zn-0.5 Mn alloy to about 183.7 MPa,approximately three times that of the as-cast(AC)Zn-0.5 Mn alloy.Moreover,compared with the AC alloy,the HPSS Zn-0.5 Mn alloy exhibited uniform degradation behavior with a markedly reduced degradation rate.
文摘Artificial intelligence(AI)is increasingly recognized as a transformative force in the field of solid organ transplantation.From enhancing donor-recipient matching to predicting clinical risks and tailoring immunosuppressive therapy,AI has the potential to improve both operational efficiency and patient outcomes.Despite these advancements,the perspectives of transplant professionals-those at the forefront of critical decision-making-remain insufficiently explored.To address this gap,this study utilizes a multi-round electronic Delphi approach to gather and analyses insights from global experts involved in organ transplantation.Participants are invited to complete structured surveys capturing demographic data,professional roles,institutional practices,and prior exposure to AI technologies.The survey also explores perceptions of AI’s potential benefits.Quantitative responses are analyzed using descriptive statistics,while open-ended qualitative responses undergo thematic analysis.Preliminary findings indicate a generally positive outlook on AI’s role in enhancing transplantation processes,particularly in areas such as donor matching and post-operative care.These mixed views reflect both optimism and caution among professionals tasked with integrating new technologies into high-stakes clinical workflows.By capturing a wide range of expert opinions,the findings will inform future policy development,regulatory considerations,and institutional readiness frameworks for the integration of AI into organ transplantation.
