AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions w...AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. Based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (< 6%) to detect the observed differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed in this study is not a "black box" but an informative tool based on the query by example model that produces, as intermediate results, visually similar annotated videos that are directly interpretable by the endoscopist. CONCLUSION:The proposed software for automated classification of pCLE videos of colonic polyps achieves high performance, comparable to that of off-line diagnosis of pCLE videos established by expert endoscopists.展开更多
Accuracy of machine learners is affected by quality of the data the learners are induced on. In this paper, quality of the training dataset is improved by removing instances detected as noisy by the Partitioning Filte...Accuracy of machine learners is affected by quality of the data the learners are induced on. In this paper, quality of the training dataset is improved by removing instances detected as noisy by the Partitioning Filter. The fit dataset is first split into subsets, and different base learners are induced on each of these splits. The predictions are combined in such a way that an instance is identified as noisy if it is misclassified by a certain number of base learners. Two versions of the Partitioning Filter are used： Multiple-Partitioning Filter and Iterative-Partitioning Filter. The number of instances removed by the filters is tuned by the voting scheme of the filter and the number of iterations. The primary aim of this study is to compare the predictive performances of the final models built on the filtered and the un-filtered training datasets. A case study of software measurement data of a high assurance software project is performed. It is shown that predictive performances of models built on the filtered fit datasets and evaluated on a noisy test dataset are generally better than those built on the noisy （un-filtered） fit dataset. However, predictive performance based on certain aggressive filters is affected by presence of noise in the evaluation dataset.展开更多
文摘AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. Based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (< 6%) to detect the observed differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed in this study is not a "black box" but an informative tool based on the query by example model that produces, as intermediate results, visually similar annotated videos that are directly interpretable by the endoscopist. CONCLUSION:The proposed software for automated classification of pCLE videos of colonic polyps achieves high performance, comparable to that of off-line diagnosis of pCLE videos established by expert endoscopists.
文摘Accuracy of machine learners is affected by quality of the data the learners are induced on. In this paper, quality of the training dataset is improved by removing instances detected as noisy by the Partitioning Filter. The fit dataset is first split into subsets, and different base learners are induced on each of these splits. The predictions are combined in such a way that an instance is identified as noisy if it is misclassified by a certain number of base learners. Two versions of the Partitioning Filter are used： Multiple-Partitioning Filter and Iterative-Partitioning Filter. The number of instances removed by the filters is tuned by the voting scheme of the filter and the number of iterations. The primary aim of this study is to compare the predictive performances of the final models built on the filtered and the un-filtered training datasets. A case study of software measurement data of a high assurance software project is performed. It is shown that predictive performances of models built on the filtered fit datasets and evaluated on a noisy test dataset are generally better than those built on the noisy （un-filtered） fit dataset. However, predictive performance based on certain aggressive filters is affected by presence of noise in the evaluation dataset.
