Objectives:SocialNetworkAddiction(SNA)is becoming increasingly prevalent among college students;however,there remains a lack of consensus regarding the measurement tools and their optimal cutoff score.This study aims ...Objectives:SocialNetworkAddiction(SNA)is becoming increasingly prevalent among college students;however,there remains a lack of consensus regarding the measurement tools and their optimal cutoff score.This study aims to validate the 21-item SocialNetwork Addiction Scale-Chinese(SNAS-C)in its Chinese version and to determine its optimal cutoff score for identifying potential SNA cases within the college student population.Methods:A crosssectional survey was conducted,recruiting 3387 college students.Latent profile analysis(LPA)and receiver operating characteristic(ROC)curve analysis were employed to establish the optimal cutoff score for the validated 21-item SNAS-C.Results:Three profile models were selected based on multiple statistical criteria,classifying participants into low-risk,moderate-risk,and high-risk groups.The highest-risk group was defined as“positive”for SNA,while the remaining groups were considered“negative”,serving as the reference standard for ROC analysis.The optimal cutoff score was determined to be 72(sensitivity:98.2%,specificity:96.86%),with an overall classification accuracy of 97.0%.The“positive”group reported significantly higher frequency of social network usage,greater digitalmedia dependence scores,and a higher incidence of network addiction.Conclusion:This study identified the optimal cutoff score for the SNAS-C as≥72,demonstrating high sensitivity,specificity,and diagnostic accuracy.This threshold effectively distinguishes between high-risk and low-risk SNA.展开更多
Marburg virus disease(MVD)is a highly fatal illness,with a case fatality rate of up to 88%,though this rate can be significantly reduced with prompt and effective patient care.The disease was first identified in 1967 ...Marburg virus disease(MVD)is a highly fatal illness,with a case fatality rate of up to 88%,though this rate can be significantly reduced with prompt and effective patient care.The disease was first identified in 1967 during concurrent outbreaks in Marburg and Frankfurt,Germany,and in Belgrade,Serbia,linked to laboratory use of African green monkeys imported from Uganda.Subsequent outbreaks and isolated cases have been reported in various African countries,including Angola,the Democratic Republic of the Congo,Equatorial Guinea,Ghana,Guinea,Kenya,Rwanda,South Africa(in an individual with recent travel to Zimbabwe),Tanzania,and Uganda.Initial human MVD infections typically occur due to prolonged exposure to mines or caves inhabited by Rousettus aegyptiacus fruit bats,the natural hosts of the virus.展开更多
The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children a...The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children and adolescents who are increasingly exposed to online grooming crimes.Early and accurate identification of grooming conversations is crucial in preventing long-term harm to victims.However,research on grooming detection in South Korea remains limited,as existing models trained primarily on English text and fail to reflect the unique linguistic features of SNS conversations,leading to inaccurate classifications.To address these issues,this study proposes a novel framework that integrates optical character recognition(OCR)technology with KcELECTRA,a deep learning-based natural language processing(NLP)model that shows excellent performance in processing the colloquial Korean language.In the proposed framework,the KcELECTRA model is fine-tuned by an extensive dataset,including Korean social media conversations,Korean ethical verification data from AI-Hub,and Korean hate speech data from Hug-gingFace,to enable more accurate classification of text extracted from social media conversation images.Experimental results show that the proposed framework achieves an accuracy of 0.953,outperforming existing transformer-based models.Furthermore,OCR technology shows high accuracy in extracting text from images,demonstrating that the proposed framework is effective for online grooming detection.The proposed framework is expected to contribute to the more accurate detection of grooming text and the prevention of grooming-related crimes.展开更多
The construction of“park cities”requires a systematic thinking to coordinate the networked development of park system and break through the limitation of emphasizing scale and grade and neglecting dynamic correlatio...The construction of“park cities”requires a systematic thinking to coordinate the networked development of park system and break through the limitation of emphasizing scale and grade and neglecting dynamic correlation in traditional planning.Taking Haidian District of Beijing as an example,the social network analysis method is introduced to construct the network model of park green spaces.Through indicators such as clustering coefficient,network density and node centrality,the characteristics of its spatial structure and hierarchical relationship are analyzed.It is found that the network integrity presents the characteristics of“highly local concentration and global fragmentation”,fragmented park green space network and missing spatial connection,isolated clusters and collaborative failure,as well as the spatial mismatch between population and resource supply and demand.Hierarchical issues include“structural imbalance and functional disorder”,disorder between network hierarchy and park level,misalignment of functional hierarchy leading to weakened network risk resistance capacity,and a relatively dense distribution of core nodes,etc.In response to the above problems,a multi-level spatial intervention strategy should be adopted to solve the overall problem of the network.Meanwhile,it is needed to clarify the positioning of a park itself and improve the hierarchical system,so as to construct a multi-level and multi-scale park green space network,contribute to the construction of a park city,and provide residents with more diverse activity venues.展开更多
Social networks are vital for building the livelihood resilience of rural households.However,the impact of social networks on rural household livelihood resilience remains em-pirically underexplored,and most existing ...Social networks are vital for building the livelihood resilience of rural households.However,the impact of social networks on rural household livelihood resilience remains em-pirically underexplored,and most existing studies do not disaggregate social networks into different dimensions,which limits the understanding of specific mechanisms.Based on 895 household samples collected in China's Dabie Mountains and structural equation modeling,this paper explored the pathway to enhance livelihood resilience through social networks by dis-aggregating it into five dimensions:network size,interaction intensity,social cohesion,social support,and social learning.The results indicate that:(1)Livelihood assets,adaptive capacity and safety nets significantly contribute to livelihood resilience,whereas sensitivity negatively affects it.Accessibility to basic services has no significant relationship with livelihood resilience in the study area.(2)Social networks and their five dimensions positively impact livelihood re-silience,with network support having the greatest impact.Therefore,both the government and rural households should recognize and enhance the role of social networks in improving liveli-hood resilience under frequent disturbances.These findings have valuable implications for mitigating the risks of poverty recurrence and contributing to rural revitalization.展开更多
Dynamic publishing of social network graphs offers insights into user behavior but brings privacy risks, notably re-identification attacks on evolving data snapshots. Existing methods based on -anonymity can mitigate ...Dynamic publishing of social network graphs offers insights into user behavior but brings privacy risks, notably re-identification attacks on evolving data snapshots. Existing methods based on -anonymity can mitigate these attacks but are cumbersome, neglect dynamic protection of community structure, and lack precise utility measures. To address these challenges, we present a dynamic social network graph anonymity scheme with community structure protection (DSNGA-CSP), which achieves the dynamic anonymization process by incorporating community detection. First, DSNGA-CSP categorizes communities of the original graph into three types at each timestamp, and only partitions community subgraphs for a specific category at each updated timestamp. Then, DSNGA-CSP achieves intra-community and inter-community anonymization separately to retain more of the community structure of the original graph at each timestamp. It anonymizes community subgraphs by the proposed novel -composition method and anonymizes inter-community edges by edge isomorphism. Finally, a novel information loss metric is introduced in DSNGA-CSP to precisely capture the utility of the anonymized graph through original information preservation and anonymous information changes. Extensive experiments conducted on five real-world datasets demonstrate that DSNGA-CSP consistently outperforms existing methods, providing a more effective balance between privacy and utility. Specifically, DSNGA-CSP shows an average utility improvement of approximately 30% compared to TAKG and CTKGA for three dynamic graph datasets, according to the proposed information loss metric IL.展开更多
Intensely using online social networks(OSNs)makes users concerned about privacy of data.Given the centralized nature of these platforms,and since each platform has a particular storage mechanism,authentication,and acc...Intensely using online social networks(OSNs)makes users concerned about privacy of data.Given the centralized nature of these platforms,and since each platform has a particular storage mechanism,authentication,and access control,their users do not have the control and the right over their data.Therefore,users cannot easily switch between similar platforms or transfer data from one platform to another.These issues imply,among other things,a threat to privacy since such users depend on the interests of the service provider responsible for administering OSNs.As a strategy for the decentralization of the OSNs and,consequently,as a solution to the privacy problems in these environments,the so-called decentralized online social networks(DOSNs)have emerged.Unlike OSNs,DOSNs are decentralized content management platforms because they do not use centralized service providers.Although DOSNs address some of the privacy issues encountered in OSNs,DOSNs also pose significant challenges to consider,for example,access control to user profile information with high granularity.This work proposes developing an ontological model and a service to support privacy in DOSNs.The model describes the main concepts of privacy access control in DOSNs and their relationships.In addition,the service will consume the model to apply access control according to the policies represented in the model.Our model was evaluated in two phases to verify its compliance with the proposed domain.Finally,we evaluated our service with a performance evaluation,and the results were satisfactory concerning the response time of access control requests.展开更多
Social interaction with peer pressure is widely studied in social network analysis.Game theory can be utilized to model dynamic social interaction,and one class of game network models assumes that people’s decision p...Social interaction with peer pressure is widely studied in social network analysis.Game theory can be utilized to model dynamic social interaction,and one class of game network models assumes that people’s decision payoff functions hinge on individual covariates and the choices of their friends.However,peer pressure would be misidentified and induce a non-negligible bias when incomplete covariates are involved in the game model.For this reason,we develop a generalized constant peer effects model based on homogeneity structure in dynamic social networks.The new model can effectively avoid bias through homogeneity pursuit and can be applied to a wider range of scenarios.To estimate peer pressure in the model,we first present two algorithms based on the initialize expand merge method and the polynomial-time twostage method to estimate homogeneity parameters.Then we apply the nested pseudo-likelihood method and obtain consistent estimators of peer pressure.Simulation evaluations show that our proposed methodology can achieve desirable and effective results in terms of the community misclassification rate and parameter estimation error.We also illustrate the advantages of our model in the empirical analysis when compared with a benchmark model.展开更多
With the rapid development of the internet,the dissemination of public opinion in online social networks has become increasingly complex.Existing dissemination models rarely consider group phenomena and the simultaneo...With the rapid development of the internet,the dissemination of public opinion in online social networks has become increasingly complex.Existing dissemination models rarely consider group phenomena and the simultaneous spread of competing public opinion information in online social networks.This paper introduces the UHNPR information dissemination model to study the dynamic spread and interaction of positive and negative public opinion information in hypernetworks.To improve the accuracy of modeling of information dissemination,we revise the traditional assumptions of constant propagation and decay rates by redefining these rates based on factors that influence the spread of public opinion information.Subsequently,we validate the effectiveness of the UHNPR model using numerical simulations and analyze the impact of factors such as authority effect,user intimacy,information content and information timeliness on the spread of public opinion,providing corresponding suggestions for public opinion control.Our research results demonstrate that this model outperforms the SIR,SEIR and SEIDR models in describing public opinion propagation in real social networks.Compared with complex networks,information spreads faster and more extensively in hypernetworks.展开更多
Cryptocurrency has gained popularity as a potential new global payment method.It has the potential to be faster,cheaper,and more secure than existing payment networks,making it a game-changer in the global economy.How...Cryptocurrency has gained popularity as a potential new global payment method.It has the potential to be faster,cheaper,and more secure than existing payment networks,making it a game-changer in the global economy.However,more research is needed to identify the factors driving cryptocurrency adoption and understand its impact.We use social network analysis(SNA)to identify the influencing factors and reveal the impact of each on cryptocurrency adoption.Our analysis initially revealed 44 influential factors,which were later reduced to 25 factors,each exerting a different influence.Based on the SNA,we classify these factors into highly,moderately,and least influential categories.Discomfort and optimism are the most influential determinants of adoption.Moderately influential factors include trust,risk,relative advantage,social influence,and perceived behavioral control.Price/value,facilitating conditions,compatibility,and usefulness are the least influential.The factors affecting cryptocurrency adoption are interdependent.Our findings can help policymakers understand the factors influencing cryptocurrency adoption and aid in developing appropriate legal frameworks for cryptocurrency use.展开更多
Objective Observational studies have shown inconsistent associations of loneliness or social isolation(SI)with ischemic heart disease(IHD),with unknown mediators.Methods Using data from genome-wide association studies...Objective Observational studies have shown inconsistent associations of loneliness or social isolation(SI)with ischemic heart disease(IHD),with unknown mediators.Methods Using data from genome-wide association studies of predominantly European ancestry,we performed a bidirectional two-sample Mendelian Randomization(MR)study to estimate causal effects of loneliness(N=487,647)and SI traits on IHD(N=184,305).SI traits included whether individuals lived alone,participated in various types of social activities,and how often they had contact with friends or family(N=459,830 to 461,369).A network MR study was conducted to evaluate the mediating roles of 20 candidate mediators,including metabolic,behavioral and psychological factors.Results Loneliness increased IHD risk(OR=2.129;95%confidence interval[CI]:1.380 to 3.285),mediated by body fat percentage,waist-hip ratio,total cholesterol,and low-density lipoprotein cholesterol.For SI traits,only fewer social activities increased IHD risk(OR=1.815;95%CI:1.189 to 2.772),mediated by hypertension,high-density lipoprotein cholesterol,triglycerides,fasting insulin,and smoking cessation.No reverse causality of IHD with loneliness and SI was found.Conclusion These findings suggested more attention should be paid to individuals who feel lonely and have fewer social activities to prevent IHD,with several mediators as prioritized targets for intervention.展开更多
The idea of a network society was introduced by Western sociologists at the end of the 20th century after in-depth research was conducted from perspectives such as informationalism.Influenced by these developments,the...The idea of a network society was introduced by Western sociologists at the end of the 20th century after in-depth research was conducted from perspectives such as informationalism.Influenced by these developments,the concept of constructing a network society also emerged in China.Over the past 30 years,China has made significant progress and achievements in constructing a network society,both in terms of its fundamental construction and social development.It is important that these advancements be summarized and reviewed.China’s network society construction can be divided into two relatively independent yet interconnected components,based on their focal points:its foundational infrastructure and its social development.These two components of China’s network society are managed by different departments.China has integrated the fundamental construction of its network society with the social development of its network society,thereby achieving unified planning,collaborative advancement,and coordinated development.This approach aims to harmonize two aspects:building China’s cyberspace strength and contributing to Chinese informatization,thereby advancing Chinese modernization.展开更多
Information spreading has been investigated for many years,but the mechanism of why the information explosively catches on overnight is still under debate.This explosive spreading phenomenon was usually considered dri...Information spreading has been investigated for many years,but the mechanism of why the information explosively catches on overnight is still under debate.This explosive spreading phenomenon was usually considered driven separately by social reinforcement or higher-order interactions.However,due to the limitations of empirical data and theoretical analysis,how the higher-order network structure affects the explosive information spreading under the role of social reinforcement has not been fully explored.In this work,we propose an information-spreading model by considering the social reinforcement in real and synthetic higher-order networks,describable as hypergraphs.Depending on the average group size(hyperedge cardinality)and node membership(hyperdegree),we observe two different spreading behaviors:(i)The spreading progress is not sensitive to social reinforcement,resulting in the information localized in a small part of nodes;(ii)a strong social reinforcement will promote the large-scale spread of information and induce an explosive transition.Moreover,a large average group size and membership would be beneficial to the appearance of the explosive transition.Further,we display that the heterogeneity of the node membership and group size distributions benefit the information spreading.Finally,we extend the group-based approximate master equations to verify the simulation results.Our findings may help us to comprehend the rapidly information-spreading phenomenon in modern society.展开更多
The social progress index(SPI)measures social and environmental performance beyond traditional economic indicators,providing transparent and actionable insights into the true condition of societies.This study investig...The social progress index(SPI)measures social and environmental performance beyond traditional economic indicators,providing transparent and actionable insights into the true condition of societies.This study investigates the interdependencies among SPI components and their impact on country-level sustainability performance.Using a Bayesian Belief Network(BBN)approach,the analysis explores the interdependencies among 12 SPI components(including advanced education,basic education,environmental quality,freedom and choice,health,housing,inclusive society,information and communications,nutrition and medical care,rights and voice,safety,and water and sanitation)and their collective influence on sustainability performance.Data from the Sustainable Development Report and SPI datasets,covering 162 countries(including Australia,China,United Arab Emirates,United Kingdom,United States,and so on),were used to assess the relative importance of each SPI component.The key findings indicate that advanced education,inclusive society,and freedom and choice make substantial contributions to high sustainability performance,whereas deficiencies in nutrition and medical care,water and sanitation,and freedom and choice are associated with poor sustainability performance.The results reveal that sustainability performance is shaped by a network of interlinked SPI components,with education and inclusion emerging as key levers for progress.The study emphasizes that targeted improvements in specific SPI components can significantly enhance a country’s overall sustainability performance.Rather than visualizing countries’progress through composite indicator-based heat maps,this study explores the interdependencies among SPI components and their role in sustainability performance at the global level.The study underscores the importance of a multidimensional policy approach that addresses social and environmental factors to enhance sustainability.The findings contribute to a deeper understanding of how SPI components interact and shape sustainable development.展开更多
Cyber-Physical Networks(CPN)are comprehensive systems that integrate information and physical domains,and are widely used in various fields such as online social networking,smart grids,and the Internet of Vehicles(IoV...Cyber-Physical Networks(CPN)are comprehensive systems that integrate information and physical domains,and are widely used in various fields such as online social networking,smart grids,and the Internet of Vehicles(IoV).With the increasing popularity of digital photography and Internet technology,more and more users are sharing images on CPN.However,many images are shared without any privacy processing,exposing hidden privacy risks and making sensitive content easily accessible to Artificial Intelligence(AI)algorithms.Existing image sharing methods lack fine-grained image sharing policies and cannot protect user privacy.To address this issue,we propose a social relationship-driven privacy customization protection model for publishers and co-photographers.We construct a heterogeneous social information network centered on social relationships,introduce a user intimacy evaluation method with time decay,and evaluate privacy levels considering user interest similarity.To protect user privacy while maintaining image appreciation,we design a lightweight face-swapping algorithm based on Generative Adversarial Network(GAN)to swap faces that need to be protected.Our proposed method minimizes the loss of image utility while satisfying privacy requirements,as shown by extensive theoretical and simulation analyses.展开更多
Social media has emerged as one of the most transformative developments on the internet,revolu-tionizing the way people communicate and interact.However,alongside its benefits,social media has also given rise to signi...Social media has emerged as one of the most transformative developments on the internet,revolu-tionizing the way people communicate and interact.However,alongside its benefits,social media has also given rise to significant challenges,one of the most pressing being cyberbullying.This issue has become a major concern in modern society,particularly due to its profound negative impacts on the mental health and well-being of its victims.In the Arab world,where social media usage is exceptionblly high,cyberbullying has become increasingly prevalent,necessitating urgent attention.Early detection of harmful online behavior is critical to fostering safer digital environments and mitigating the adverse efcts of cyberbullying.This underscores the importance of developing advanced tools and systems to identify and address such behavior efectively.This paper investigates the development of a robust cyberbullying detection and classifcation system tailored for Arabic comments on YouTube.The study explores the efectiveness of various deep learning models,including Bi-LSTM(Bidirectional Long Short Term Memory),LSTM(Long Short-Term Memory),CNN(Convolutional Neural Networks),and a hybrid CNN-LSTM,in classifying Arabic comments into binary classes(bullying or not)and multiclass categories.A comprehensive dataset of 20,000 Arabic YouTube comments was collected,preprocessed,and labeled to support these tasks.The results revealed that the CNN and hybrid CNN-LSTM models achieved the highest accuracy in binary classification,reaching an impressive 91.9%.For multiclass dlassification,the LSTM and Bi-LSTM models outperformed others,achieving an accuracy of 89.5%.These findings highlight the efctiveness of deep learning approaches in the mitigation of cyberbullying within Arabic online communities.展开更多
BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes tha...BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.展开更多
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o...Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.展开更多
BACKGROUND Low anterior resection syndrome(LARS)is a prevalent and debilitating complication following sphincter-preserving surgery for rectal cancer.Evidence-based interventions for the concurrent psychological burde...BACKGROUND Low anterior resection syndrome(LARS)is a prevalent and debilitating complication following sphincter-preserving surgery for rectal cancer.Evidence-based interventions for the concurrent psychological burden are limited.Electroacupuncture has been proposed as a potential adjunctive therapy,but its psychological benefits remain inadequately studied.AIM To investigate the therapeutic effect of electroacupuncture on emotional recovery and gastrointestinal function in patients with moderate to severe LARS,and to explore its potential advantages in psychologically vulnerable subgroups.METHODS We conducted a retrospective,controlled study involving 100 patients with moderate to severe LARS(LARS score≥21)treated at two tertiary hospitals in China between January 2022 and December 2024.Patients received either standard postoperative care alone(n=50)or in combination with a standardized 4-week electroacupuncture protocol(n=50).Psychological and functional outcomes were assessed using validated instruments including Hospital Anxiety and Depression Scale(HADS),Body Image Scale(BIS),General Self-Efficacy Scale,Perceived Social Support Scale(PSSS),LARS score,and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 at four time points.The primary endpoint was emotional remission,defined as a≥3-point reduction in HADS-Anxiety subscale(HADS-A).Analyses included repeated-measures comparisons,Kaplan-Meier survival curves,Cox regression models,and subgroup-interaction testing.RESULTS At baseline,demographic,surgical,and psychosocial characteristics were comparable among groups.By week 4,patients receiving electroacupuncture demonstrated significantly greater reductions in anxiety(HADS-A:4.8±2.6 vs 7.3±3.0;P<0.001),depression,and body-image disturbance(BIS:8.7±3.6 vs 11.9±4.2;P<0.001),alongside enhanced coping capacity(Brief Coping Orientation to Problems Experienced),perceived social support(PSSS),and bowel function(LARS score).Emotional remission-defined as a≥3-point HADS-A reduction-was achieved more rapidly in the electroacupuncture group,as confirmed by Kaplan-Meier analysis(log-rank P<0.001;odds ratio=4.7).Multivariate Cox regression identified higher baseline LARS and BIS scores as independent predictors of delayed emotional recovery.Subgroup analyses revealed significantly amplified treatment benefits in patients with high baseline anxiety(HADS-A≥8),elevated body-image disturbance(BIS≥12),or low perceived social support(PSSS<60),with consistent interaction effects(P for interaction<0.05 across subgroups).CONCLUSION Electroacupuncture may accelerate emotional recovery and improve functional and psychosocial outcomes in patients with LARS.Its integration into postoperative care may offer particular benefits for psychologically vulnerable subgroups.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.72364006).
文摘Objectives:SocialNetworkAddiction(SNA)is becoming increasingly prevalent among college students;however,there remains a lack of consensus regarding the measurement tools and their optimal cutoff score.This study aims to validate the 21-item SocialNetwork Addiction Scale-Chinese(SNAS-C)in its Chinese version and to determine its optimal cutoff score for identifying potential SNA cases within the college student population.Methods:A crosssectional survey was conducted,recruiting 3387 college students.Latent profile analysis(LPA)and receiver operating characteristic(ROC)curve analysis were employed to establish the optimal cutoff score for the validated 21-item SNAS-C.Results:Three profile models were selected based on multiple statistical criteria,classifying participants into low-risk,moderate-risk,and high-risk groups.The highest-risk group was defined as“positive”for SNA,while the remaining groups were considered“negative”,serving as the reference standard for ROC analysis.The optimal cutoff score was determined to be 72(sensitivity:98.2%,specificity:96.86%),with an overall classification accuracy of 97.0%.The“positive”group reported significantly higher frequency of social network usage,greater digitalmedia dependence scores,and a higher incidence of network addiction.Conclusion:This study identified the optimal cutoff score for the SNAS-C as≥72,demonstrating high sensitivity,specificity,and diagnostic accuracy.This threshold effectively distinguishes between high-risk and low-risk SNA.
文摘Marburg virus disease(MVD)is a highly fatal illness,with a case fatality rate of up to 88%,though this rate can be significantly reduced with prompt and effective patient care.The disease was first identified in 1967 during concurrent outbreaks in Marburg and Frankfurt,Germany,and in Belgrade,Serbia,linked to laboratory use of African green monkeys imported from Uganda.Subsequent outbreaks and isolated cases have been reported in various African countries,including Angola,the Democratic Republic of the Congo,Equatorial Guinea,Ghana,Guinea,Kenya,Rwanda,South Africa(in an individual with recent travel to Zimbabwe),Tanzania,and Uganda.Initial human MVD infections typically occur due to prolonged exposure to mines or caves inhabited by Rousettus aegyptiacus fruit bats,the natural hosts of the virus.
基金supported by the IITP(Institute of Information&Communications Technology Planning&Evaluation)-ITRC(Information Technology Research Center)grant funded by the Korean government(Ministry of Science and ICT)(IITP-2025-RS-2024-00438056).
文摘The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children and adolescents who are increasingly exposed to online grooming crimes.Early and accurate identification of grooming conversations is crucial in preventing long-term harm to victims.However,research on grooming detection in South Korea remains limited,as existing models trained primarily on English text and fail to reflect the unique linguistic features of SNS conversations,leading to inaccurate classifications.To address these issues,this study proposes a novel framework that integrates optical character recognition(OCR)technology with KcELECTRA,a deep learning-based natural language processing(NLP)model that shows excellent performance in processing the colloquial Korean language.In the proposed framework,the KcELECTRA model is fine-tuned by an extensive dataset,including Korean social media conversations,Korean ethical verification data from AI-Hub,and Korean hate speech data from Hug-gingFace,to enable more accurate classification of text extracted from social media conversation images.Experimental results show that the proposed framework achieves an accuracy of 0.953,outperforming existing transformer-based models.Furthermore,OCR technology shows high accuracy in extracting text from images,demonstrating that the proposed framework is effective for online grooming detection.The proposed framework is expected to contribute to the more accurate detection of grooming text and the prevention of grooming-related crimes.
文摘The construction of“park cities”requires a systematic thinking to coordinate the networked development of park system and break through the limitation of emphasizing scale and grade and neglecting dynamic correlation in traditional planning.Taking Haidian District of Beijing as an example,the social network analysis method is introduced to construct the network model of park green spaces.Through indicators such as clustering coefficient,network density and node centrality,the characteristics of its spatial structure and hierarchical relationship are analyzed.It is found that the network integrity presents the characteristics of“highly local concentration and global fragmentation”,fragmented park green space network and missing spatial connection,isolated clusters and collaborative failure,as well as the spatial mismatch between population and resource supply and demand.Hierarchical issues include“structural imbalance and functional disorder”,disorder between network hierarchy and park level,misalignment of functional hierarchy leading to weakened network risk resistance capacity,and a relatively dense distribution of core nodes,etc.In response to the above problems,a multi-level spatial intervention strategy should be adopted to solve the overall problem of the network.Meanwhile,it is needed to clarify the positioning of a park itself and improve the hierarchical system,so as to construct a multi-level and multi-scale park green space network,contribute to the construction of a park city,and provide residents with more diverse activity venues.
基金National Natural Science Foundation of China,No.42371315,No.41901213。
文摘Social networks are vital for building the livelihood resilience of rural households.However,the impact of social networks on rural household livelihood resilience remains em-pirically underexplored,and most existing studies do not disaggregate social networks into different dimensions,which limits the understanding of specific mechanisms.Based on 895 household samples collected in China's Dabie Mountains and structural equation modeling,this paper explored the pathway to enhance livelihood resilience through social networks by dis-aggregating it into five dimensions:network size,interaction intensity,social cohesion,social support,and social learning.The results indicate that:(1)Livelihood assets,adaptive capacity and safety nets significantly contribute to livelihood resilience,whereas sensitivity negatively affects it.Accessibility to basic services has no significant relationship with livelihood resilience in the study area.(2)Social networks and their five dimensions positively impact livelihood re-silience,with network support having the greatest impact.Therefore,both the government and rural households should recognize and enhance the role of social networks in improving liveli-hood resilience under frequent disturbances.These findings have valuable implications for mitigating the risks of poverty recurrence and contributing to rural revitalization.
基金supported by the Natural Science Foundation of China(No.U22A2099)the Innovation Project of Guangxi Graduate Education(YCBZ2023130).
文摘Dynamic publishing of social network graphs offers insights into user behavior but brings privacy risks, notably re-identification attacks on evolving data snapshots. Existing methods based on -anonymity can mitigate these attacks but are cumbersome, neglect dynamic protection of community structure, and lack precise utility measures. To address these challenges, we present a dynamic social network graph anonymity scheme with community structure protection (DSNGA-CSP), which achieves the dynamic anonymization process by incorporating community detection. First, DSNGA-CSP categorizes communities of the original graph into three types at each timestamp, and only partitions community subgraphs for a specific category at each updated timestamp. Then, DSNGA-CSP achieves intra-community and inter-community anonymization separately to retain more of the community structure of the original graph at each timestamp. It anonymizes community subgraphs by the proposed novel -composition method and anonymizes inter-community edges by edge isomorphism. Finally, a novel information loss metric is introduced in DSNGA-CSP to precisely capture the utility of the anonymized graph through original information preservation and anonymous information changes. Extensive experiments conducted on five real-world datasets demonstrate that DSNGA-CSP consistently outperforms existing methods, providing a more effective balance between privacy and utility. Specifically, DSNGA-CSP shows an average utility improvement of approximately 30% compared to TAKG and CTKGA for three dynamic graph datasets, according to the proposed information loss metric IL.
基金Fundação de AmparoàPesquisa do Estado da Bahia(FAPESB),Coordenação de Aperfeiçoamento de Pessoal de Nível Superior(CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)organizations for supporting the Graduate Program in Computer Science at the Federal University of Bahia.
文摘Intensely using online social networks(OSNs)makes users concerned about privacy of data.Given the centralized nature of these platforms,and since each platform has a particular storage mechanism,authentication,and access control,their users do not have the control and the right over their data.Therefore,users cannot easily switch between similar platforms or transfer data from one platform to another.These issues imply,among other things,a threat to privacy since such users depend on the interests of the service provider responsible for administering OSNs.As a strategy for the decentralization of the OSNs and,consequently,as a solution to the privacy problems in these environments,the so-called decentralized online social networks(DOSNs)have emerged.Unlike OSNs,DOSNs are decentralized content management platforms because they do not use centralized service providers.Although DOSNs address some of the privacy issues encountered in OSNs,DOSNs also pose significant challenges to consider,for example,access control to user profile information with high granularity.This work proposes developing an ontological model and a service to support privacy in DOSNs.The model describes the main concepts of privacy access control in DOSNs and their relationships.In addition,the service will consume the model to apply access control according to the policies represented in the model.Our model was evaluated in two phases to verify its compliance with the proposed domain.Finally,we evaluated our service with a performance evaluation,and the results were satisfactory concerning the response time of access control requests.
基金supported by the National Nature Science Foundation of China(71771201,72531009,71973001)the USTC Research Funds of the Double First-Class Initiative(FSSF-A-240202).
文摘Social interaction with peer pressure is widely studied in social network analysis.Game theory can be utilized to model dynamic social interaction,and one class of game network models assumes that people’s decision payoff functions hinge on individual covariates and the choices of their friends.However,peer pressure would be misidentified and induce a non-negligible bias when incomplete covariates are involved in the game model.For this reason,we develop a generalized constant peer effects model based on homogeneity structure in dynamic social networks.The new model can effectively avoid bias through homogeneity pursuit and can be applied to a wider range of scenarios.To estimate peer pressure in the model,we first present two algorithms based on the initialize expand merge method and the polynomial-time twostage method to estimate homogeneity parameters.Then we apply the nested pseudo-likelihood method and obtain consistent estimators of peer pressure.Simulation evaluations show that our proposed methodology can achieve desirable and effective results in terms of the community misclassification rate and parameter estimation error.We also illustrate the advantages of our model in the empirical analysis when compared with a benchmark model.
基金supported by Yunnan High-tech Industry Development Project(Grant No.201606)Yunnan Provincial Major Science and Technology Special Plan Projects(Grant Nos.202103AA080015 and 202002AD080001-5)+1 种基金Yunnan Basic Research Project(Grant No.202001AS070014)Talents and Platform Program of Science and Technology of Yunnan(Grant No.202105AC160018)。
文摘With the rapid development of the internet,the dissemination of public opinion in online social networks has become increasingly complex.Existing dissemination models rarely consider group phenomena and the simultaneous spread of competing public opinion information in online social networks.This paper introduces the UHNPR information dissemination model to study the dynamic spread and interaction of positive and negative public opinion information in hypernetworks.To improve the accuracy of modeling of information dissemination,we revise the traditional assumptions of constant propagation and decay rates by redefining these rates based on factors that influence the spread of public opinion information.Subsequently,we validate the effectiveness of the UHNPR model using numerical simulations and analyze the impact of factors such as authority effect,user intimacy,information content and information timeliness on the spread of public opinion,providing corresponding suggestions for public opinion control.Our research results demonstrate that this model outperforms the SIR,SEIR and SEIDR models in describing public opinion propagation in real social networks.Compared with complex networks,information spreads faster and more extensively in hypernetworks.
文摘Cryptocurrency has gained popularity as a potential new global payment method.It has the potential to be faster,cheaper,and more secure than existing payment networks,making it a game-changer in the global economy.However,more research is needed to identify the factors driving cryptocurrency adoption and understand its impact.We use social network analysis(SNA)to identify the influencing factors and reveal the impact of each on cryptocurrency adoption.Our analysis initially revealed 44 influential factors,which were later reduced to 25 factors,each exerting a different influence.Based on the SNA,we classify these factors into highly,moderately,and least influential categories.Discomfort and optimism are the most influential determinants of adoption.Moderately influential factors include trust,risk,relative advantage,social influence,and perceived behavioral control.Price/value,facilitating conditions,compatibility,and usefulness are the least influential.The factors affecting cryptocurrency adoption are interdependent.Our findings can help policymakers understand the factors influencing cryptocurrency adoption and aid in developing appropriate legal frameworks for cryptocurrency use.
基金supported by the National Natural Science Foundation of China(82322059)the Chinese Academy of Medical·Sciences Innovation Fund for Medical Sciences(2021-I2M-1-010)+1 种基金the National Key Research and Development Program of China(2021YFC2500500)the National High Level Hospital Clinical Research Funding(2023-GSPRC-19).
文摘Objective Observational studies have shown inconsistent associations of loneliness or social isolation(SI)with ischemic heart disease(IHD),with unknown mediators.Methods Using data from genome-wide association studies of predominantly European ancestry,we performed a bidirectional two-sample Mendelian Randomization(MR)study to estimate causal effects of loneliness(N=487,647)and SI traits on IHD(N=184,305).SI traits included whether individuals lived alone,participated in various types of social activities,and how often they had contact with friends or family(N=459,830 to 461,369).A network MR study was conducted to evaluate the mediating roles of 20 candidate mediators,including metabolic,behavioral and psychological factors.Results Loneliness increased IHD risk(OR=2.129;95%confidence interval[CI]:1.380 to 3.285),mediated by body fat percentage,waist-hip ratio,total cholesterol,and low-density lipoprotein cholesterol.For SI traits,only fewer social activities increased IHD risk(OR=1.815;95%CI:1.189 to 2.772),mediated by hypertension,high-density lipoprotein cholesterol,triglycerides,fasting insulin,and smoking cessation.No reverse causality of IHD with loneliness and SI was found.Conclusion These findings suggested more attention should be paid to individuals who feel lonely and have fewer social activities to prevent IHD,with several mediators as prioritized targets for intervention.
基金“Research on Social Change and Network Society Planning in the Internet of Everything Era”(ID:21BSH005),a project under the National Social Science Fund of China
文摘The idea of a network society was introduced by Western sociologists at the end of the 20th century after in-depth research was conducted from perspectives such as informationalism.Influenced by these developments,the concept of constructing a network society also emerged in China.Over the past 30 years,China has made significant progress and achievements in constructing a network society,both in terms of its fundamental construction and social development.It is important that these advancements be summarized and reviewed.China’s network society construction can be divided into two relatively independent yet interconnected components,based on their focal points:its foundational infrastructure and its social development.These two components of China’s network society are managed by different departments.China has integrated the fundamental construction of its network society with the social development of its network society,thereby achieving unified planning,collaborative advancement,and coordinated development.This approach aims to harmonize two aspects:building China’s cyberspace strength and contributing to Chinese informatization,thereby advancing Chinese modernization.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12305043 and 12165016)the Natural Science Foundation of Jiangsu Province(Grant No.BK20220511)+1 种基金the Project of Undergraduate Scientific Research(Grant No.22A684)the support from the Jiangsu Specially-Appointed Professor Program。
文摘Information spreading has been investigated for many years,but the mechanism of why the information explosively catches on overnight is still under debate.This explosive spreading phenomenon was usually considered driven separately by social reinforcement or higher-order interactions.However,due to the limitations of empirical data and theoretical analysis,how the higher-order network structure affects the explosive information spreading under the role of social reinforcement has not been fully explored.In this work,we propose an information-spreading model by considering the social reinforcement in real and synthetic higher-order networks,describable as hypergraphs.Depending on the average group size(hyperedge cardinality)and node membership(hyperdegree),we observe two different spreading behaviors:(i)The spreading progress is not sensitive to social reinforcement,resulting in the information localized in a small part of nodes;(ii)a strong social reinforcement will promote the large-scale spread of information and induce an explosive transition.Moreover,a large average group size and membership would be beneficial to the appearance of the explosive transition.Further,we display that the heterogeneity of the node membership and group size distributions benefit the information spreading.Finally,we extend the group-based approximate master equations to verify the simulation results.Our findings may help us to comprehend the rapidly information-spreading phenomenon in modern society.
基金the resources and support provided by the American University of Sharjah to conduct this research
文摘The social progress index(SPI)measures social and environmental performance beyond traditional economic indicators,providing transparent and actionable insights into the true condition of societies.This study investigates the interdependencies among SPI components and their impact on country-level sustainability performance.Using a Bayesian Belief Network(BBN)approach,the analysis explores the interdependencies among 12 SPI components(including advanced education,basic education,environmental quality,freedom and choice,health,housing,inclusive society,information and communications,nutrition and medical care,rights and voice,safety,and water and sanitation)and their collective influence on sustainability performance.Data from the Sustainable Development Report and SPI datasets,covering 162 countries(including Australia,China,United Arab Emirates,United Kingdom,United States,and so on),were used to assess the relative importance of each SPI component.The key findings indicate that advanced education,inclusive society,and freedom and choice make substantial contributions to high sustainability performance,whereas deficiencies in nutrition and medical care,water and sanitation,and freedom and choice are associated with poor sustainability performance.The results reveal that sustainability performance is shaped by a network of interlinked SPI components,with education and inclusion emerging as key levers for progress.The study emphasizes that targeted improvements in specific SPI components can significantly enhance a country’s overall sustainability performance.Rather than visualizing countries’progress through composite indicator-based heat maps,this study explores the interdependencies among SPI components and their role in sustainability performance at the global level.The study underscores the importance of a multidimensional policy approach that addresses social and environmental factors to enhance sustainability.The findings contribute to a deeper understanding of how SPI components interact and shape sustainable development.
基金supported in part by National Natural Science Foundation of China(62271096,U20A20157)Natural Science Foundation of Chongqing,China(cstc2020jcyj-zdxmX0024,CSTB2022NSCQMSX0600)+5 种基金University Innovation Research Group of Chongqing(CXQT20017)Program for Innovation Team Building at Institutions of Higher Education in Chongqing(CXTDX201601020)Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202000626)Youth Innovation Group Support Program of ICE Discipline of CQUPT(SCIE-QN-2022-04)the Science and Technology Research Program of Chongqing Municipal Education Commission under Grant KJQN202000626Chongqing Municipal Technology Innovation and Application Development Special Key Project(cstc2020jscx-dxwtBX0053)。
文摘Cyber-Physical Networks(CPN)are comprehensive systems that integrate information and physical domains,and are widely used in various fields such as online social networking,smart grids,and the Internet of Vehicles(IoV).With the increasing popularity of digital photography and Internet technology,more and more users are sharing images on CPN.However,many images are shared without any privacy processing,exposing hidden privacy risks and making sensitive content easily accessible to Artificial Intelligence(AI)algorithms.Existing image sharing methods lack fine-grained image sharing policies and cannot protect user privacy.To address this issue,we propose a social relationship-driven privacy customization protection model for publishers and co-photographers.We construct a heterogeneous social information network centered on social relationships,introduce a user intimacy evaluation method with time decay,and evaluate privacy levels considering user interest similarity.To protect user privacy while maintaining image appreciation,we design a lightweight face-swapping algorithm based on Generative Adversarial Network(GAN)to swap faces that need to be protected.Our proposed method minimizes the loss of image utility while satisfying privacy requirements,as shown by extensive theoretical and simulation analyses.
基金financed by the European Union-NextGenerationEU,through the National Recowery and Resilience Plan of the Republic of Bulgaria,Project No.BG-RRP-2.013-0001-C01.
文摘Social media has emerged as one of the most transformative developments on the internet,revolu-tionizing the way people communicate and interact.However,alongside its benefits,social media has also given rise to significant challenges,one of the most pressing being cyberbullying.This issue has become a major concern in modern society,particularly due to its profound negative impacts on the mental health and well-being of its victims.In the Arab world,where social media usage is exceptionblly high,cyberbullying has become increasingly prevalent,necessitating urgent attention.Early detection of harmful online behavior is critical to fostering safer digital environments and mitigating the adverse efcts of cyberbullying.This underscores the importance of developing advanced tools and systems to identify and address such behavior efectively.This paper investigates the development of a robust cyberbullying detection and classifcation system tailored for Arabic comments on YouTube.The study explores the efectiveness of various deep learning models,including Bi-LSTM(Bidirectional Long Short Term Memory),LSTM(Long Short-Term Memory),CNN(Convolutional Neural Networks),and a hybrid CNN-LSTM,in classifying Arabic comments into binary classes(bullying or not)and multiclass categories.A comprehensive dataset of 20,000 Arabic YouTube comments was collected,preprocessed,and labeled to support these tasks.The results revealed that the CNN and hybrid CNN-LSTM models achieved the highest accuracy in binary classification,reaching an impressive 91.9%.For multiclass dlassification,the LSTM and Bi-LSTM models outperformed others,achieving an accuracy of 89.5%.These findings highlight the efctiveness of deep learning approaches in the mitigation of cyberbullying within Arabic online communities.
基金Supported by Key Research and Development Program of Shaanxi Province,China,No.2024SF-YBXM-078.
文摘BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.
基金supported by grants from the National Natural Science Foundation of China(82004252)the Project of Administration of Traditional Chinese Medicine of Guangdong Province(202405112017596500)the Basic and Applied Basic Research Foundation of Guangzhou Municipal Science and Technology Bureau(202102020533).
文摘Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.
文摘BACKGROUND Low anterior resection syndrome(LARS)is a prevalent and debilitating complication following sphincter-preserving surgery for rectal cancer.Evidence-based interventions for the concurrent psychological burden are limited.Electroacupuncture has been proposed as a potential adjunctive therapy,but its psychological benefits remain inadequately studied.AIM To investigate the therapeutic effect of electroacupuncture on emotional recovery and gastrointestinal function in patients with moderate to severe LARS,and to explore its potential advantages in psychologically vulnerable subgroups.METHODS We conducted a retrospective,controlled study involving 100 patients with moderate to severe LARS(LARS score≥21)treated at two tertiary hospitals in China between January 2022 and December 2024.Patients received either standard postoperative care alone(n=50)or in combination with a standardized 4-week electroacupuncture protocol(n=50).Psychological and functional outcomes were assessed using validated instruments including Hospital Anxiety and Depression Scale(HADS),Body Image Scale(BIS),General Self-Efficacy Scale,Perceived Social Support Scale(PSSS),LARS score,and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 at four time points.The primary endpoint was emotional remission,defined as a≥3-point reduction in HADS-Anxiety subscale(HADS-A).Analyses included repeated-measures comparisons,Kaplan-Meier survival curves,Cox regression models,and subgroup-interaction testing.RESULTS At baseline,demographic,surgical,and psychosocial characteristics were comparable among groups.By week 4,patients receiving electroacupuncture demonstrated significantly greater reductions in anxiety(HADS-A:4.8±2.6 vs 7.3±3.0;P<0.001),depression,and body-image disturbance(BIS:8.7±3.6 vs 11.9±4.2;P<0.001),alongside enhanced coping capacity(Brief Coping Orientation to Problems Experienced),perceived social support(PSSS),and bowel function(LARS score).Emotional remission-defined as a≥3-point HADS-A reduction-was achieved more rapidly in the electroacupuncture group,as confirmed by Kaplan-Meier analysis(log-rank P<0.001;odds ratio=4.7).Multivariate Cox regression identified higher baseline LARS and BIS scores as independent predictors of delayed emotional recovery.Subgroup analyses revealed significantly amplified treatment benefits in patients with high baseline anxiety(HADS-A≥8),elevated body-image disturbance(BIS≥12),or low perceived social support(PSSS<60),with consistent interaction effects(P for interaction<0.05 across subgroups).CONCLUSION Electroacupuncture may accelerate emotional recovery and improve functional and psychosocial outcomes in patients with LARS.Its integration into postoperative care may offer particular benefits for psychologically vulnerable subgroups.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
