Descriptive signs in radiology can aid in easier pattern recognition and quicker diagnosis.In spinal cord ischemia,paired anterior-horn T2-hyperintensities have traditionally been known as the“owl’s eyes”or“snake ...Descriptive signs in radiology can aid in easier pattern recognition and quicker diagnosis.In spinal cord ischemia,paired anterior-horn T2-hyperintensities have traditionally been known as the“owl’s eyes”or“snake eyes”sign.We discuss how these signs,while visually apt,convey no pathophysiologic context and propose renaming this finding the“snake bite sign”.The image still evokes two punctate marks,yet the metaphor extends to a snake bite(two fang-like dots)rather than two bright foci(eyes)staring back at the viewer.Moreover,besides the sign metaphorically resembling a traumatic puncture of the two fangs,on the occasion of a venomous snake bite occurring elsewhere,additional neurological consequences may occur,paralleling the neurological deficits seen in anterior spinal artery infarction and several mimicking myelopathies,thus further high-lighting the analogy.Such clinically driven terminology may facilitate teaching,enable diagnostic recall,and improve interdisciplinary communication.展开更多
The global incidence of Alzheimer's Disease(AD)is on a swift rise.The Electroencephalogram(EEG)signals is an effective tool for the identification of AD and its initial Mild Cognitive Impairment(MCI)stage using ma...The global incidence of Alzheimer's Disease(AD)is on a swift rise.The Electroencephalogram(EEG)signals is an effective tool for the identification of AD and its initial Mild Cognitive Impairment(MCI)stage using machine learning models.Analysis of AD using EEG involves multi-channel analysis.However,the use of multiple channels may impact the classification performance due to data redundancy and complexity.In this work,a hybrid EEG channel selection is proposed using a combination of Reptile Search Algorithm and Snake Optimizer(RSO)for AD and MCI detection based on decomposition methods.Empirical Mode Decomposition(EMD),Low-Complexity Orthogonal Wavelet Filter Banks(LCOWFB),Variational Mode Decomposition,and discrete-wavelet transform decomposition techniques have been employed for subbands-based EEG analysis.We extracted thirty-four features from each subband of EEG signals.Finally,a hybrid RSO optimizer is compared with five individual metaheuristic algorithms for effective channel selection.The effectiveness of this model is assessed by two publicly accessible AD EEG datasets.An accuracy of 99.22% was achieved for binary classification from RSO with EMD using 4(out of 16)EEG channels.Moreover,the RSO with LCOWFBs obtained 89.68%the average accuracy for three-class classification using 7(out of 19)channels.The performance reveals that RSO performs better than individual Metaheuristic algorithms with 60%fewer channels and improved accuracy of 4%than existing AD detection techniques.展开更多
The Chinese Opera Season 2025 and International Exhibition of Chinese Opera opened in Vienna,the capital of Austria,on the evening of April 5.As the opening performance of the Season,a traditional Wu Opera(a local ope...The Chinese Opera Season 2025 and International Exhibition of Chinese Opera opened in Vienna,the capital of Austria,on the evening of April 5.As the opening performance of the Season,a traditional Wu Opera(a local opera in Zhejiang Province)scene"the Legend of the White Snake"was performed at the Muth Theatre in Vienna,drawing enthusiastic responses.展开更多
In ancient China,the snake was worshipped as a totem.In Chinese mythology,Nüwa and Fuxi,the deities who created humans,were half human and half snake.Folk art depicts them as conjoined,with interlocked tails.Whil...In ancient China,the snake was worshipped as a totem.In Chinese mythology,Nüwa and Fuxi,the deities who created humans,were half human and half snake.Folk art depicts them as conjoined,with interlocked tails.While in Western culture the serpent is regarded as the tempter who caused the fall of man,in ancient Chinese philosophy,the snake is a symbol of fertility and vitality.As it has the disposition to shed skin,the snake is also emblematic of regeneration and a new beginning.展开更多
Objective:To develop a rapid diagnostic kit for identifying snake venom types,aimed at providing a basis for clinical diagnosis and laying a foundation for early treatment through quick blood testing of injured patien...Objective:To develop a rapid diagnostic kit for identifying snake venom types,aimed at providing a basis for clinical diagnosis and laying a foundation for early treatment through quick blood testing of injured patients.Methods:Anti-snake venom immunoglobulin(IgG)was prepared,biotinylated specific IgG was screened,detection enzyme-labeled strips were produced,and rapid identification of snakebites was performed.Pre-experimental verification was conducted to establish standard curves and confirm specificity.The kit was tested on clinical samples and the results were analyzed.Repeatability and stability were evaluated through multiple repeated tests and experiments under different storage conditions.Finally,sensitivity and specificity were calculated,receiver operating characteristic curves(ROC curves)were drawn,and statistical analysis software was used for data analysis to ensure the reliability and effectiveness of the kit.Results:The test showed high sensitivity and specificity.Conclusion:The rapid diagnostic kit for identifying snake venom types in blood tests demonstrates high reliability and effectiveness in clinical diagnosis.展开更多
Influenced by rapid changes in climate and landscape features since the Miocene,widely distributed species provide suitable models to study the environmental impact on their evolution and current genetic diversity.The...Influenced by rapid changes in climate and landscape features since the Miocene,widely distributed species provide suitable models to study the environmental impact on their evolution and current genetic diversity.The dice snake Natrix tessellata,widely distributed in the Western Palearctic is one such species.We aimed to resolve a detailed phylogeography of N.tessellata with a focus on the Central Asian clade with 4 and the Anatolia clade with 3 mitochondrial lineages,trace their origin,and correlate the environmental changes that affected their distribution through time.The expected time of divergence of both clades began at 3.7 Mya in the Pliocene,reaching lineage differentiation approximately 1 million years later.The genetic diversity in both clades is rich,suggesting different ancestral areas,glacial refugia,demographic changes,and colonization routes.The Caspian lineage is the most widespread lineage in Central Asia,distributed around the Caspian Sea and reaching the foothills of the Hindu Kush Mountains in Afghanistan,and Eastern European lowlands in the west.Its distribution is limited by deserts,moun-tains,and cold steppe environments.Similarly,Kazakhstan and Uzbekistan lineages followed the Amu Darya and the Syr Darya water systems in Central Asia,with ranges delimited by the large Kyzylkum and Karakum deserts.On the western side,there are several lineages within the Anatolia clade that converged in the central part of the peninsula with 2 being endemic to Western Asia.The distribution of both main clades was affected by expansion from their Pleistocene glacial refugia around the Caspian Sea and in the valleys of Central Asia as well as by environmental changes,mostly through aridification.展开更多
Snakebite has become a serious public health problem with high mortality and disability rates.Ultrasound can provide imaging basis for diagnosis and treatment of snakebites and relative complications.The application p...Snakebite has become a serious public health problem with high mortality and disability rates.Ultrasound can provide imaging basis for diagnosis and treatment of snakebites and relative complications.The application progresses of ultrasound in snakebites and complications were reviewed in this article.展开更多
A wireless sensor network mobile target tracking algorithm(ISO-EKF)based on improved snake optimization algorithm(ISO)is proposed to address the difficulty of estimating initial values when using extended Kalman filte...A wireless sensor network mobile target tracking algorithm(ISO-EKF)based on improved snake optimization algorithm(ISO)is proposed to address the difficulty of estimating initial values when using extended Kalman filtering to solve the state of nonlinear mobile target tracking.First,the steps of extended Kalman filtering(EKF)are introduced.Second,the ISO is used to adjust the parameters of the EKF in real time to adapt to the current motion state of the mobile target.Finally,the effectiveness of the algorithm is demonstrated through filtering and tracking using the constant velocity circular motion model(CM).Under the specified conditions,the position and velocity mean square error curves are compared among the snake optimizer(SO)-EKF algorithm,EKF algorithm,and the proposed algorithm.The comparison shows that the proposed algorithm reduces the root mean square error of position by 52%and 41%compared to the SOEKF algorithm and EKF algorithm,respectively.展开更多
Snake Optimizer(SO)is a novel Meta-heuristic Algorithm(MA)inspired by the mating behaviour of snakes,which has achieved success in global numerical optimization problems and practical engineering applications.However,...Snake Optimizer(SO)is a novel Meta-heuristic Algorithm(MA)inspired by the mating behaviour of snakes,which has achieved success in global numerical optimization problems and practical engineering applications.However,it also has certain drawbacks for the exploration stage and the egg hatch process,resulting in slow convergence speed and inferior solution quality.To address the above issues,a novel multi-strategy improved SO(MISO)with the assistance of population crowding analysis is proposed in this article.In the algorithm,a novel multi-strategy operator is designed for the exploration stage,which not only focuses on using the information of better performing individuals to improve the quality of solution,but also focuses on maintaining population diversity.To boost the efficiency of the egg hatch process,the multi-strategy egg hatch process is proposed to regenerate individuals according to the results of the population crowding analysis.In addition,a local search method is employed to further enhance the convergence speed and the local search capability.MISO is first compared with three sets of algorithms in the CEC2020 benchmark functions,including SO with its two recently discussed variants,ten advanced MAs,and six powerful CEC competition algorithms.The performance of MISO is then verified on five practical engineering design problems.The experimental results show that MISO provides a promising performance for the above optimization cases in terms of convergence speed and solution quality.展开更多
Snake venom disintegrins,through their inhibition of integrin-related binding,effectively impede both cell-cell and cell-matrix interactions as well as signal transduction pathways,rendering them promising candidates ...Snake venom disintegrins,through their inhibition of integrin-related binding,effectively impede both cell-cell and cell-matrix interactions as well as signal transduction pathways,rendering them promising candidates for lead therapeutics across a spectrum of diseases.This study aimed to conduct a comprehensive bibliometric analysis,elucidating recent trends in disintegrin research.Using relevant keywords,we meticulously explored the Web of Science Core Collection(WOSCC)database.Employing CiteSpace and VOSviewer,we conducted an exhaustive analysis,encompassing 142 documents published between 2009 and 2023.These publications,dispersed across 74 journals,involved 670 authors representing 207 institutes spanning 42 countries.Notably,the United States contributed the highest number of records,with Texas A&M University emerging as the most prolific institution.Within this landscape,Elda E.Sanchez emerged as the foremost author,and Toxicon emerged as the predominant journal.Keyword analysis underscored prevailing research foci,with an emphasis on expression,in vitro experimentation,and ASP-containing peptides.This study presented a comprehensive overview of disintegrin research globally,spanning the period from 2009 to 2023,and held potential utility in guiding future research endeavors.By identifying current research hotspots,our findings offered invaluable insights to shape forthcoming investigations in this dynamic field.展开更多
文摘Descriptive signs in radiology can aid in easier pattern recognition and quicker diagnosis.In spinal cord ischemia,paired anterior-horn T2-hyperintensities have traditionally been known as the“owl’s eyes”or“snake eyes”sign.We discuss how these signs,while visually apt,convey no pathophysiologic context and propose renaming this finding the“snake bite sign”.The image still evokes two punctate marks,yet the metaphor extends to a snake bite(two fang-like dots)rather than two bright foci(eyes)staring back at the viewer.Moreover,besides the sign metaphorically resembling a traumatic puncture of the two fangs,on the occasion of a venomous snake bite occurring elsewhere,additional neurological consequences may occur,paralleling the neurological deficits seen in anterior spinal artery infarction and several mimicking myelopathies,thus further high-lighting the analogy.Such clinically driven terminology may facilitate teaching,enable diagnostic recall,and improve interdisciplinary communication.
文摘The global incidence of Alzheimer's Disease(AD)is on a swift rise.The Electroencephalogram(EEG)signals is an effective tool for the identification of AD and its initial Mild Cognitive Impairment(MCI)stage using machine learning models.Analysis of AD using EEG involves multi-channel analysis.However,the use of multiple channels may impact the classification performance due to data redundancy and complexity.In this work,a hybrid EEG channel selection is proposed using a combination of Reptile Search Algorithm and Snake Optimizer(RSO)for AD and MCI detection based on decomposition methods.Empirical Mode Decomposition(EMD),Low-Complexity Orthogonal Wavelet Filter Banks(LCOWFB),Variational Mode Decomposition,and discrete-wavelet transform decomposition techniques have been employed for subbands-based EEG analysis.We extracted thirty-four features from each subband of EEG signals.Finally,a hybrid RSO optimizer is compared with five individual metaheuristic algorithms for effective channel selection.The effectiveness of this model is assessed by two publicly accessible AD EEG datasets.An accuracy of 99.22% was achieved for binary classification from RSO with EMD using 4(out of 16)EEG channels.Moreover,the RSO with LCOWFBs obtained 89.68%the average accuracy for three-class classification using 7(out of 19)channels.The performance reveals that RSO performs better than individual Metaheuristic algorithms with 60%fewer channels and improved accuracy of 4%than existing AD detection techniques.
文摘The Chinese Opera Season 2025 and International Exhibition of Chinese Opera opened in Vienna,the capital of Austria,on the evening of April 5.As the opening performance of the Season,a traditional Wu Opera(a local opera in Zhejiang Province)scene"the Legend of the White Snake"was performed at the Muth Theatre in Vienna,drawing enthusiastic responses.
文摘In ancient China,the snake was worshipped as a totem.In Chinese mythology,Nüwa and Fuxi,the deities who created humans,were half human and half snake.Folk art depicts them as conjoined,with interlocked tails.While in Western culture the serpent is regarded as the tempter who caused the fall of man,in ancient Chinese philosophy,the snake is a symbol of fertility and vitality.As it has the disposition to shed skin,the snake is also emblematic of regeneration and a new beginning.
基金Rapid Identification and Analysis of Snake Venom Types in Snakebites in Renshou County,(Project No.:2024KJZD072)。
文摘Objective:To develop a rapid diagnostic kit for identifying snake venom types,aimed at providing a basis for clinical diagnosis and laying a foundation for early treatment through quick blood testing of injured patients.Methods:Anti-snake venom immunoglobulin(IgG)was prepared,biotinylated specific IgG was screened,detection enzyme-labeled strips were produced,and rapid identification of snakebites was performed.Pre-experimental verification was conducted to establish standard curves and confirm specificity.The kit was tested on clinical samples and the results were analyzed.Repeatability and stability were evaluated through multiple repeated tests and experiments under different storage conditions.Finally,sensitivity and specificity were calculated,receiver operating characteristic curves(ROC curves)were drawn,and statistical analysis software was used for data analysis to ensure the reliability and effectiveness of the kit.Results:The test showed high sensitivity and specificity.Conclusion:The rapid diagnostic kit for identifying snake venom types in blood tests demonstrates high reliability and effectiveness in clinical diagnosis.
基金supported by the Slovak Research and Development Agency under the contract APVV-19-0076 and by the grant VEGA 1/0242/21 of the Scientific Grant Agency of the Slovak RepublicSH was supported by the German Research Foundation(DFG,grant no.HO 3792/8-1)The work of OK was carried out within the framework of research topics of the state assignments nos.121032300023-7 and 122031100282-2.The research of DJ in Afghanistan has been approved by the National Environmental Protection Agency of the Islamic Emirate of Afghanistan(permits for access to genetic resources nos.12429 and 12455).
文摘Influenced by rapid changes in climate and landscape features since the Miocene,widely distributed species provide suitable models to study the environmental impact on their evolution and current genetic diversity.The dice snake Natrix tessellata,widely distributed in the Western Palearctic is one such species.We aimed to resolve a detailed phylogeography of N.tessellata with a focus on the Central Asian clade with 4 and the Anatolia clade with 3 mitochondrial lineages,trace their origin,and correlate the environmental changes that affected their distribution through time.The expected time of divergence of both clades began at 3.7 Mya in the Pliocene,reaching lineage differentiation approximately 1 million years later.The genetic diversity in both clades is rich,suggesting different ancestral areas,glacial refugia,demographic changes,and colonization routes.The Caspian lineage is the most widespread lineage in Central Asia,distributed around the Caspian Sea and reaching the foothills of the Hindu Kush Mountains in Afghanistan,and Eastern European lowlands in the west.Its distribution is limited by deserts,moun-tains,and cold steppe environments.Similarly,Kazakhstan and Uzbekistan lineages followed the Amu Darya and the Syr Darya water systems in Central Asia,with ranges delimited by the large Kyzylkum and Karakum deserts.On the western side,there are several lineages within the Anatolia clade that converged in the central part of the peninsula with 2 being endemic to Western Asia.The distribution of both main clades was affected by expansion from their Pleistocene glacial refugia around the Caspian Sea and in the valleys of Central Asia as well as by environmental changes,mostly through aridification.
文摘Snakebite has become a serious public health problem with high mortality and disability rates.Ultrasound can provide imaging basis for diagnosis and treatment of snakebites and relative complications.The application progresses of ultrasound in snakebites and complications were reviewed in this article.
基金supported by National Natural Science Foundation of China (Nos.62265010,62061024)Gansu Province Science and Technology Plan (No.23YFGA0062)Gansu Province Innovation Fund (No.2022A-215)。
文摘A wireless sensor network mobile target tracking algorithm(ISO-EKF)based on improved snake optimization algorithm(ISO)is proposed to address the difficulty of estimating initial values when using extended Kalman filtering to solve the state of nonlinear mobile target tracking.First,the steps of extended Kalman filtering(EKF)are introduced.Second,the ISO is used to adjust the parameters of the EKF in real time to adapt to the current motion state of the mobile target.Finally,the effectiveness of the algorithm is demonstrated through filtering and tracking using the constant velocity circular motion model(CM).Under the specified conditions,the position and velocity mean square error curves are compared among the snake optimizer(SO)-EKF algorithm,EKF algorithm,and the proposed algorithm.The comparison shows that the proposed algorithm reduces the root mean square error of position by 52%and 41%compared to the SOEKF algorithm and EKF algorithm,respectively.
基金supported by Grant(42271391 and 62006214)from National Natural Science Foundation of Chinaby Grant(8091B022148)from Joint Funds of Equipment Pre-Research and Ministry of Education of China+1 种基金by Grant(2023BIB015)from Special Project of Hubei Key Research and Development Programby Grant(KLIGIP-2021B03)from Open Research Project of the Hubei Key Laboratory of Intelligent Geo-Information Processing.
文摘Snake Optimizer(SO)is a novel Meta-heuristic Algorithm(MA)inspired by the mating behaviour of snakes,which has achieved success in global numerical optimization problems and practical engineering applications.However,it also has certain drawbacks for the exploration stage and the egg hatch process,resulting in slow convergence speed and inferior solution quality.To address the above issues,a novel multi-strategy improved SO(MISO)with the assistance of population crowding analysis is proposed in this article.In the algorithm,a novel multi-strategy operator is designed for the exploration stage,which not only focuses on using the information of better performing individuals to improve the quality of solution,but also focuses on maintaining population diversity.To boost the efficiency of the egg hatch process,the multi-strategy egg hatch process is proposed to regenerate individuals according to the results of the population crowding analysis.In addition,a local search method is employed to further enhance the convergence speed and the local search capability.MISO is first compared with three sets of algorithms in the CEC2020 benchmark functions,including SO with its two recently discussed variants,ten advanced MAs,and six powerful CEC competition algorithms.The performance of MISO is then verified on five practical engineering design problems.The experimental results show that MISO provides a promising performance for the above optimization cases in terms of convergence speed and solution quality.
基金Startup Fund for Scientific Research,Fujian Medical University(Grant No.2022QH1216)。
文摘Snake venom disintegrins,through their inhibition of integrin-related binding,effectively impede both cell-cell and cell-matrix interactions as well as signal transduction pathways,rendering them promising candidates for lead therapeutics across a spectrum of diseases.This study aimed to conduct a comprehensive bibliometric analysis,elucidating recent trends in disintegrin research.Using relevant keywords,we meticulously explored the Web of Science Core Collection(WOSCC)database.Employing CiteSpace and VOSviewer,we conducted an exhaustive analysis,encompassing 142 documents published between 2009 and 2023.These publications,dispersed across 74 journals,involved 670 authors representing 207 institutes spanning 42 countries.Notably,the United States contributed the highest number of records,with Texas A&M University emerging as the most prolific institution.Within this landscape,Elda E.Sanchez emerged as the foremost author,and Toxicon emerged as the predominant journal.Keyword analysis underscored prevailing research foci,with an emphasis on expression,in vitro experimentation,and ASP-containing peptides.This study presented a comprehensive overview of disintegrin research globally,spanning the period from 2009 to 2023,and held potential utility in guiding future research endeavors.By identifying current research hotspots,our findings offered invaluable insights to shape forthcoming investigations in this dynamic field.
