This work presents a novel coordinated control strategy of a hybrid photovoltaic/battery energy storage(PV/BES) system. Different controller operation modes are simulated considering normal, high fluctuation and emerg...This work presents a novel coordinated control strategy of a hybrid photovoltaic/battery energy storage(PV/BES) system. Different controller operation modes are simulated considering normal, high fluctuation and emergency conditions. When the system is grid-connected, BES regulates the fluctuated power output which ensures smooth net injected power from the PV/BES system. In islanded operation, BES system is transferred to single master operation during which the frequency and voltage of the islanded microgrid are regulated at the desired level. PSCAD/EMTDC simulation validates the proposed method and obtained favorable results on power set-point tracking strategies with very small deviations of net output power compared to the power set-point. The state-of-charge regulation scheme also very effective with SOC has been regulated between 32% and 79% range.展开更多
The contact stiffness of the joint surface directly affects the static and dynamic mechanical behavior,and accuracy of the machine tool.A new elastoplastic contact stiffness model is proposed by considering continuous...The contact stiffness of the joint surface directly affects the static and dynamic mechanical behavior,and accuracy of the machine tool.A new elastoplastic contact stiffness model is proposed by considering continuous and smooth contact characteristics and substrate deformation.First,the interpolation interval of cubic Hermite polynomials is improved to meet the continuous and smooth change of contact parameters during asperity deformation.Then,the micro-contact mechanism considering substrate deformation is explored by establishing an asperity-substrate system model.Furthermore,combined with statistical principles,a new contact stiffness model of the joint surface is established.Finally,the correctness of the built model is verified by comparing with experimental data and different contact models.The simulation results show that the model changes continuously and smoothly in the three deformation regions.The substrate deformation mainly affects the asperities in the elastic contact stage.The smoother is the surface,the more significant is the influence of substrate deformation.展开更多
Residual strength is an indispensable factor in evaluating rock fracture,yet the current Smoothed Particle Hydrodynamics(SPH)framework rarely considers its influence when simulating fracture.An improved cracking strat...Residual strength is an indispensable factor in evaluating rock fracture,yet the current Smoothed Particle Hydrodynamics(SPH)framework rarely considers its influence when simulating fracture.An improved cracking strategy considering residual stress in the base bond SPH method was proposed to simulate failures in layered rocks and slopes and verified by experimental results and other simulation methods(i.e.,the discrete element method).Modified Mohr–Coulomb failure criterion was applied to distinguish the mixed failure of tensile and shear.Bond fracture markψwas introduced to improve the kernel function after tensile damage,and the calculation of residual stress after the damage was derived after shear damage.Numerical simulations were carried out to evaluate its performance under different stress and scale conditions and to verify its effectiveness in realistically reproducing crack initiation and propagation and coalescence,even fracture and separation.The results indicate that the improved cracking strategy precisely captures the fracture and failure pattern in layered rocks and rock slopes.The residual stress of brittle tock is correctly captured by the improved SPH method.The improved SPH method that considers residual strength shows an approximately 13%improvement in accuracy for the safety factor of anti-dip layered slopes compared to the method that does not consider residual strength,as validated against analytical solutions.We infer that the improved SPH method is effective and shows promise for applications to continuous and discontinuous rock masses.展开更多
AIM: To investigate the effect and the possible mechanism of ginsenoside Rb1 on small intestinal smooth muscle motility in mice. METHODS: Intestinal smooth muscle strips were isolated from male ICR mice (5 wk old), an...AIM: To investigate the effect and the possible mechanism of ginsenoside Rb1 on small intestinal smooth muscle motility in mice. METHODS: Intestinal smooth muscle strips were isolated from male ICR mice (5 wk old), and the effect of ginsenoside Rb1 on spontaneous contraction was recorded with an electrophysiolograph. The effect of ginsenoside Rb1 on ion channel currents, including the voltage-gated K + channel current (IK V ), calcium-activated potassium channel currents (IK Ca ), spontaneous transient outward currents and ATP-sensitive potassium channel current (IK ATP ), was recorded on freshly isolated single cells using the whole-cell patch clamp technique. RESULTS: Ginsenoside Rb1 dose-dependently inhibited the spontaneous contraction of intestinal smooth muscle by 21.15% ± 3.31%, 42.03% ± 8.23% and 67.23% ± 5.63% at concentrations of 25 μmol/L, 50 μmol/L and 100 μmol/L, respectively (n=5,P<0.05). The inhibitory effect of ginsenoside Rb1 on spontaneous contraction was significantly but incompletely blocked by 10 mmol/L tetraethylammonium or 0.5 mmol/L 4-aminopyridine, respectively (n=5, P<0.05). However, the inhibitory effect of ginsenoside Rb1 on spontaneous contraction was not affected by 10 μmol/L glibenclamide or 0.4 μmol/L tetrodotoxin. At the cell level, ginsenoside Rb1 increased outward potassium currents, and IK V was enhanced from 1137.71 ± 171.62 pA to 1449.73 ± 162.39 pA by 50 μmol/L Rb1 at +60 mV (n=6, P<0.05). Ginsenoside Rb1 increased IK Ca and enhanced the amplitudes of spontaneous transient outward currents from 582.77 ± 179.09 mV to 788.12 ± 278.34 mV (n=5, P<0.05). However, ginsenoside Rb1 (50 μmol/L) had no significant effect on IK ATP (n=3, P<0.05). CONCLUSION: These results suggest that ginsenoside Rb1 has an inhibitory effect on the spontaneous contraction of mouse intestinal smooth muscle mediated by the activation of IK V and IK Ca , but the K ATP channel was not involved in this effect.展开更多
Accurate prediction of refrigerant boiling heat transfer coefficients is important for the design of evaporators. The generalized correlations have different forms, and could not provide satisfactory results for R22 a...Accurate prediction of refrigerant boiling heat transfer coefficients is important for the design of evaporators. The generalized correlations have different forms, and could not provide satisfactory results for R22 and its alternative refrigerants R134a, R407C and R410A. This study proposes to use artificial neural network (ANNs) as a generalized correlation model, selects the input parameters of ANNs on the basis of the dimensionless parameter groups of existing correlations, and correlates the in-tube boiling heat transfer coefficients of the above four refrigerants. The results show that the ANNs model with the input and output based on the Liu-Winterton correlation has the best result. The root-mean-square deviations in training and test are 15.5% and 20.2% respectively, and approximately 85% of the deviations are within ±20%, which is much better than that of the existing generalized correlations.展开更多
On February 24, 1993, when the appraisal meeting of the Sino-Japanese Joint Research Project of Well-off Household Residences was held in Beijing, Person-in-charge from the China Building Technology Development and Re...On February 24, 1993, when the appraisal meeting of the Sino-Japanese Joint Research Project of Well-off Household Residences was held in Beijing, Person-in-charge from the China Building Technology Development and Research Centre and the Japan International Cooperation Undertakings Group signed the project appraisal report. It marked the successful completion of this three-year joint research project.展开更多
In this study, the North China seismic region was selected as the study area, and evaluation of seismic hazard using the spatial smoothing seismicity model was performed. Firstly, the study area is divided into grids,...In this study, the North China seismic region was selected as the study area, and evaluation of seismic hazard using the spatial smoothing seismicity model was performed. Firstly, the study area is divided into grids, and some parameters （e. g. b-value, Mo, Me, azimuth and M-L relationship ） for each seismotectonic model were assigned. Secondly, using elliptical smoothing based on a seismotectonic background model, the statistical earthquake incidence rate in each grid is successively calculated. Lastly, the relevant ground motion attenuation relationship is chosen to assess seismic hazard of general sites. The maps for the distribution of horizontal peak ground acceleration with 10% probability of exceedance in 50 years were obtained by using the seismic hazard analysis method based on grid source. This seismicity model simplifies the methodology of probabilistic seismic hazard analysis, especially appropriate for those places where seismic tectonics is not yet clearly known. This method can provide valuable references for seismic zonation and seismic safety assessment for significant engineering projects.展开更多
We study the Cauchy problem of the Kolmogorov-Fokker-Planck equations and show that the solution enjoys an analytic smoothing effect with L?initial datum for positive time.
A modified inner-element edge-based smoothed finite element method(IES-FEM)is developed and integrated with ABAQUS using a user-defined element(UEL)in this study.Initially,the smoothing domain discretization of IES-FE...A modified inner-element edge-based smoothed finite element method(IES-FEM)is developed and integrated with ABAQUS using a user-defined element(UEL)in this study.Initially,the smoothing domain discretization of IES-FEM is described and compared with ES-FEM.A practical modification of IES-FEM is then introduced that used the technique employed by ES-FEM for the nodal strain calculation.The differences in the strain computation among ES-FEM,IES-FEM,and FEM are then discussed.The modified IES-FEM exhibited superior performance in displacement and a slight advantage in stress compared to FEM using the same mesh according to the results obtained from both the regular and irregular elements.The robustness of the IES-FEM to severely deformed meshes was also verified.展开更多
To enable distributed PV to adapt to variations in power grid strength and achieve stable grid connection while enhancing operational flexibility,it is essential to configure grid-connected inverters with an integrate...To enable distributed PV to adapt to variations in power grid strength and achieve stable grid connection while enhancing operational flexibility,it is essential to configure grid-connected inverters with an integrated grid-following control mode,allowing smooth switching between GFL and GFM modes.First,impedance models of GFL and GFM PV energy storage VSG systems were established,and grid stability was analyzed.Second,an online impedance identification method based on voltage fluctuation data screening was proposed to enhance the accuracy of impedance identification.Additionally,a PV energy storage GFM/GFL VSG smooth switching method based on current inner loop compensation was introduced to achieve stable grid-connected operation of distributed photovoltaics under changes in strong and weak power grids.Finally,a grid stability analysis was conducted on the multi-machine parallel PV ESS,and a simulation model of a multi-machine parallel PV ESS based on current inner loop compensation was established for testing.Results showed that,compared to using a single GFM or single GFL control for the PV VSG system,the smooth switching method of multi-machine parallel PV ESS effectively suppresses system resonance under variations in power grid strength,enabling adaptive and stable grid-connected operations of distributed PV.展开更多
Vein graft(VG)failure(VGF)is associated with VG intimal hyperplasia,which is characterized by abnormal accumulation of vascular smooth muscle cells(VSMCs).Most neointimal VSMCs are derived from pre-existing VSMCs via ...Vein graft(VG)failure(VGF)is associated with VG intimal hyperplasia,which is characterized by abnormal accumulation of vascular smooth muscle cells(VSMCs).Most neointimal VSMCs are derived from pre-existing VSMCs via a process of VSMC phenotypic transition,also known as dedifferentiation.There is increasing evidence to suggest that ginger or its bioactive ingredients may block VSMC dedifferentiation,exerting vasoprotective functions;however,the precise mechanisms have not been fully characterized.Therefore,we investigated the effect of ginger on VSMC phenotypic transition in VG remodeling after transplantation.Ginger significantly inhibited neointimal hyperplasia and promoted lumen(L)opening in a 3-month VG,which was primarily achieved by reducing ferroptotic stress.Ferroptotic stress is a pro-ferroptotic state.Contractile VSMCs did not die but instead gained a proliferative capacity and switched to the secretory type,forming neointima(NI)after vein transplantation.Ginger and its two main vasoprotective ingredients(6-gingerol and 6-shogaol)inhibit VSMC dedifferentiation by reducing ferroptotic stress.Network pharmacology analysis revealed that 6-gingerol inhibits ferroptotic stress by targeting P53,while 6-shogaol inhibits ferroptotic stress by targeting 5-lipoxygenase(Alox5),both promoting ferroptosis.Furthermore,both ingredients co-target peroxisome proliferator-activated receptor gamma(PPARγ),decreasing PPARγ-mediated nicotinamide adenine dinucleotide phosphate(NADPH)oxidase 1(Nox1)expression.Nox1 promotes intracellular reactive oxygen species(ROS)production and directly induces VSMC dedifferentiation.In addition,Nox1 is a ferroptosis-promoting gene that encourages ferroptotic stress production,indirectly leading to VSMC dedifferentiation.Ginger,a natural multi-targeted ferroptotic stress inhibitor,finely and effectively prevents VSMC phenotypic transition and protects against venous injury remodeling.展开更多
The interaction between extreme waves and structures is a crucial study area in marine science,as it significantly influences safety and disaster prevention strategies for marine and coastal engineering.To investigate...The interaction between extreme waves and structures is a crucial study area in marine science,as it significantly influences safety and disaster prevention strategies for marine and coastal engineering.To investigate the flow field of a semi-submersible against extreme waves,a model simulating solitary wave interactions with the semi-submersible system was developed via the meshless smoothed particle hydrodynamics(SPH)method and Rayleigh’s theory.Notably,the wave surface and wave load results obtained from the SPH model,compared with those of OpenFOAM,result in an interaction test case between solitary waves and partially submerged rectangular obstacles and show good agreement,with a maximum relative error of 3.4%.An analysis of the calculated results of the semi-submersible facing solitary waves revealed several key findings:overtopping,which decreases with increasing water depth,occurs on the structure when the non-submerged ratio is 0.33 and the wave height surpasses 0.2 m.The transmission coefficient decreases with increasing wave height but increases as the water depth increases.Furthermore,the reflection coefficient peaks at a wave height H0=0.2 m.The dissipation coefficient displays a valley trend with a small water depth,whereas it increases monotonically with increasing water depth.The dissipation coefficient decreases with increasing water depth.展开更多
Adversarial attacks pose a significant threat to artificial intelligence systems by exposing them to vulnerabilities in deep learning models.Existing defense mechanisms often suffer drawbacks,such as the need for mode...Adversarial attacks pose a significant threat to artificial intelligence systems by exposing them to vulnerabilities in deep learning models.Existing defense mechanisms often suffer drawbacks,such as the need for model retraining,significant inference time overhead,and limited effectiveness against specific attack types.Achieving perfect defense against adversarial attacks remains elusive,emphasizing the importance of mitigation strategies.In this study,we propose a defense mechanism that applies random cropping and Gaussian filtering to input images to mitigate the impact of adversarial attacks.First,the image was randomly cropped to vary its dimensions and then placed at the center of a fixed 299299 space,with the remaining areas filled with zero padding.Subsequently,Gaussian×filtering with a 77 kernel and a standard deviation of two was applied using a convolution operation.Finally,the×smoothed image was fed into the classification model.The proposed defense method consistently appeared in the upperright region across all attack scenarios,demonstrating its ability to preserve classification performance on clean images while significantly mitigating adversarial attacks.This visualization confirms that the proposed method is effective and reliable for defending against adversarial perturbations.Moreover,the proposed method incurs minimal computational overhead,making it suitable for real-time applications.Furthermore,owing to its model-agnostic nature,the proposed method can be easily incorporated into various neural network architectures,serving as a fundamental module for adversarial defense strategies.展开更多
The traditional topology optimization method of continuum structure generally uses quadrilateral elements as the basic mesh.This approach often leads to jagged boundary issues,which are traditionally addressed through...The traditional topology optimization method of continuum structure generally uses quadrilateral elements as the basic mesh.This approach often leads to jagged boundary issues,which are traditionally addressed through post-processing,potentially altering the mechanical properties of the optimized structure.A topology optimization method of Movable Morphable Smooth Boundary(MMSB)is proposed based on the idea of mesh adaptation to solve the problem of jagged boundaries and the influence of post-processing.Based on the ICM method,the rational fraction function is introduced as the filtering function,and a topology optimization model with the minimum weight as the objective and the displacement as the constraint is established.A triangular mesh is utilized as the base mesh in this method.The mesh is re-divided in the optimization process based on the contour line,and a smooth boundary parallel to the contour line is obtained.Numerical examples demonstrate that the MMSB method effectively resolves the jagged boundary issues,leading to enhanced structural performance.展开更多
Background:Mechanical ventilation(MV)provides life support for patients with severe respiratory distress but can simultaneously cause ventilator-induced lung injury(VILI).However,due to a poor understanding of its mec...Background:Mechanical ventilation(MV)provides life support for patients with severe respiratory distress but can simultaneously cause ventilator-induced lung injury(VILI).However,due to a poor understanding of its mechanism,there is still a lack of effective remedies for the often-deadly VILI.Recent studies indicate that the stretch associated with MV can enhance the secretion of extracellular vesicles(EVs)and induce endoplasmic reticulum(ER)stress in airway smoothmuscle cells(ASMCs),both of which can contribute to VILI.But whetherMVassociated stretch enhances the secretion of EVs via ER stress in ASMCs as an underlying mechanism of VILI remains unknown.Methods:In this study,we exposed cultured human ASMCs to stretch(13%strain)and mouse models to MV at tidal volume(18 mL/kg).Subsequently,the amount of secreted EVs in the culture medium of ASMCs and the bronchoalveolar lavage fluid(BALF)of mousemodels was quantitatively evaluated by ultracentrifugation,transmission electron microscopy,Western blot,flow cytometry,and nanoparticle tracking analysis.The cultured ASMCs and the lung tissues of mouse models were assessed for expression of biomarkers of EVs(cluster of differentiation antigen 63,CD63),ER stress(heat shock protein family A member 5,HSPA5),and EVs regulating molecule Rab27a by immunofluorescence microscopy,immunohistochemistry(IHC)and enzyme-linked immunosorbent assay(ELISA),respectively.MicroRNAs(miRNAs)in EVs from ASMCs were measured with miRNA whole genome sequencing(miRNA-Seq).Results:We found that stretch enhanced EV secretion from cultured ASMCs.In addition,the cultured ASMCs and the mouse models were either or not pretreated with ER stress inhibitor(tauroursodeoxycholic acid,TUDCA)/EV secretion inhibitor(GW4869)prior to stretch or MV.We found that MV-associated stretch enhanced the expression of CD63,HSPA5,and Rab27a in cultured ASMCs and BALF/lung tissues of mousemodels,which could all be attenuated with TUDCA/GW4869 pretreatment.miRNA-Seq data show that differentially expressed miRNAs in EVsmainlymodulate gene transcription.Furthermore,the EVs fromcultured ASMCs under stretch tended to enhance detachment and expression of inflammatory cytokines,i.e.,transforming growth factor-β1(TGF-β1),interleukin-10(IL-10)in cultured airway epithelial cells.The expression of TGF-β1 and IL-10 in BALF of the mouse models also increased in response to MV,which was attenuated together with partial improvement of lung injury by pretreatment with TUDCA,GW4869/Rab27a siRNAs.Conclusion:Taken together,our data indicate thatMV-associated stretch can enhance the secretion of EVs from ASMCs via ER stress signaling to mediate airway inflammation and VILI,which provides new insight for further exploring EVs for the diagnosis and treatment of VILI.展开更多
A discontinuous smoothed particle hydrodynamics(DSPH)method considering block contacts is originally developed to model the cracking,frictional slip and large deformation in rock masses,and is verified by theoretical,...A discontinuous smoothed particle hydrodynamics(DSPH)method considering block contacts is originally developed to model the cracking,frictional slip and large deformation in rock masses,and is verified by theoretical,numerical and/or experimental results.In the DSPH method,cracking is realized by breaking the virtual bonds via a pseudo-spring method based on Mohr–Coulomb failure criteria.The damaged particles are instantaneously replaced by discontinuous particles and the contact bond between the original and discontinuous particles is formed to simulate the frictional slip and separation/contraction between fracture surfaces based on the block contact algorithm.The motion of rock blocks and the contact force of discontinuous particles are determined following Newton's second law.The results indicate that the DSPH method precisely captures the cracking,contact formation and complete failure across six numerical benchmark tests.This single smoothed particle hydrodynamics(SPH)framework could significantly improve computational efficiency and is potentially applicable to broad multi-physical rock engineering problems of different scales.展开更多
Topology optimization stands as a pivotal technique in realizing periodic microstructure design.A novel approach is proposed,integrating the energy-based homogenization method with the Floating Projection Topology Opt...Topology optimization stands as a pivotal technique in realizing periodic microstructure design.A novel approach is proposed,integrating the energy-based homogenization method with the Floating Projection Topology Optimization(FPTO)method to achieve smooth topology design.The objective is to optimize the periodic microstructure to maximize the properties of specific materials,such as bulk modulus and shear modulus,or to achieve negative Poisson's ratio.Linear material interpolation is used to eliminate the nonlinear challenges and design dependence caused by material penalty.Furthermore,the three-field density representation technique is applied to augment length scales and solid/void characteristics.Through systematic analysis and numerical simulations,the impacts of various initial designs and optimization parameters on the optimization outcomes are investigated.The results demonstrate that the optimized periodic microstructures exhibit extreme performance with clear boundaries.The identification of appropriate optimization parameters is crucial for enhancing the extreme mechanical properties of material microstructures.It can provide valuable guidance for aerospace component design involving material microstructures and metamaterials.展开更多
This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanis...This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.展开更多
Combining TT* argument and bilinear interpolation,this paper obtains the Strichartz and smoothing estimates of dispersive semigroup e^(-itP(D)) in weighted L^(2) spaces.Among other things,we recover the results in[1]....Combining TT* argument and bilinear interpolation,this paper obtains the Strichartz and smoothing estimates of dispersive semigroup e^(-itP(D)) in weighted L^(2) spaces.Among other things,we recover the results in[1].Moreover,the application of these results to the well-posedness of some equations are shown in the last section.展开更多
文摘This work presents a novel coordinated control strategy of a hybrid photovoltaic/battery energy storage(PV/BES) system. Different controller operation modes are simulated considering normal, high fluctuation and emergency conditions. When the system is grid-connected, BES regulates the fluctuated power output which ensures smooth net injected power from the PV/BES system. In islanded operation, BES system is transferred to single master operation during which the frequency and voltage of the islanded microgrid are regulated at the desired level. PSCAD/EMTDC simulation validates the proposed method and obtained favorable results on power set-point tracking strategies with very small deviations of net output power compared to the power set-point. The state-of-charge regulation scheme also very effective with SOC has been regulated between 32% and 79% range.
基金This work was supported by the National Natural Science Foundation of China(Grant Number 51975449)the Key Research and Development Program of Shaanxi(Number 2021GY-309)。
文摘The contact stiffness of the joint surface directly affects the static and dynamic mechanical behavior,and accuracy of the machine tool.A new elastoplastic contact stiffness model is proposed by considering continuous and smooth contact characteristics and substrate deformation.First,the interpolation interval of cubic Hermite polynomials is improved to meet the continuous and smooth change of contact parameters during asperity deformation.Then,the micro-contact mechanism considering substrate deformation is explored by establishing an asperity-substrate system model.Furthermore,combined with statistical principles,a new contact stiffness model of the joint surface is established.Finally,the correctness of the built model is verified by comparing with experimental data and different contact models.The simulation results show that the model changes continuously and smoothly in the three deformation regions.The substrate deformation mainly affects the asperities in the elastic contact stage.The smoother is the surface,the more significant is the influence of substrate deformation.
基金funded by the National Key Research and Development Program of China(Grant No.2023YFC3008300,Grant No.2019YFC1509702)the National Natural Science Foundation of China(Grant No.42172296).
文摘Residual strength is an indispensable factor in evaluating rock fracture,yet the current Smoothed Particle Hydrodynamics(SPH)framework rarely considers its influence when simulating fracture.An improved cracking strategy considering residual stress in the base bond SPH method was proposed to simulate failures in layered rocks and slopes and verified by experimental results and other simulation methods(i.e.,the discrete element method).Modified Mohr–Coulomb failure criterion was applied to distinguish the mixed failure of tensile and shear.Bond fracture markψwas introduced to improve the kernel function after tensile damage,and the calculation of residual stress after the damage was derived after shear damage.Numerical simulations were carried out to evaluate its performance under different stress and scale conditions and to verify its effectiveness in realistically reproducing crack initiation and propagation and coalescence,even fracture and separation.The results indicate that the improved cracking strategy precisely captures the fracture and failure pattern in layered rocks and rock slopes.The residual stress of brittle tock is correctly captured by the improved SPH method.The improved SPH method that considers residual strength shows an approximately 13%improvement in accuracy for the safety factor of anti-dip layered slopes compared to the method that does not consider residual strength,as validated against analytical solutions.We infer that the improved SPH method is effective and shows promise for applications to continuous and discontinuous rock masses.
基金Supported by The National Natural Science Foundation of China, No. 30873328The State Administration of Traditional Chinese Medicine of the People’s Republic of China, No. 06-075930
文摘AIM: To investigate the effect and the possible mechanism of ginsenoside Rb1 on small intestinal smooth muscle motility in mice. METHODS: Intestinal smooth muscle strips were isolated from male ICR mice (5 wk old), and the effect of ginsenoside Rb1 on spontaneous contraction was recorded with an electrophysiolograph. The effect of ginsenoside Rb1 on ion channel currents, including the voltage-gated K + channel current (IK V ), calcium-activated potassium channel currents (IK Ca ), spontaneous transient outward currents and ATP-sensitive potassium channel current (IK ATP ), was recorded on freshly isolated single cells using the whole-cell patch clamp technique. RESULTS: Ginsenoside Rb1 dose-dependently inhibited the spontaneous contraction of intestinal smooth muscle by 21.15% ± 3.31%, 42.03% ± 8.23% and 67.23% ± 5.63% at concentrations of 25 μmol/L, 50 μmol/L and 100 μmol/L, respectively (n=5,P<0.05). The inhibitory effect of ginsenoside Rb1 on spontaneous contraction was significantly but incompletely blocked by 10 mmol/L tetraethylammonium or 0.5 mmol/L 4-aminopyridine, respectively (n=5, P<0.05). However, the inhibitory effect of ginsenoside Rb1 on spontaneous contraction was not affected by 10 μmol/L glibenclamide or 0.4 μmol/L tetrodotoxin. At the cell level, ginsenoside Rb1 increased outward potassium currents, and IK V was enhanced from 1137.71 ± 171.62 pA to 1449.73 ± 162.39 pA by 50 μmol/L Rb1 at +60 mV (n=6, P<0.05). Ginsenoside Rb1 increased IK Ca and enhanced the amplitudes of spontaneous transient outward currents from 582.77 ± 179.09 mV to 788.12 ± 278.34 mV (n=5, P<0.05). However, ginsenoside Rb1 (50 μmol/L) had no significant effect on IK ATP (n=3, P<0.05). CONCLUSION: These results suggest that ginsenoside Rb1 has an inhibitory effect on the spontaneous contraction of mouse intestinal smooth muscle mediated by the activation of IK V and IK Ca , but the K ATP channel was not involved in this effect.
文摘Accurate prediction of refrigerant boiling heat transfer coefficients is important for the design of evaporators. The generalized correlations have different forms, and could not provide satisfactory results for R22 and its alternative refrigerants R134a, R407C and R410A. This study proposes to use artificial neural network (ANNs) as a generalized correlation model, selects the input parameters of ANNs on the basis of the dimensionless parameter groups of existing correlations, and correlates the in-tube boiling heat transfer coefficients of the above four refrigerants. The results show that the ANNs model with the input and output based on the Liu-Winterton correlation has the best result. The root-mean-square deviations in training and test are 15.5% and 20.2% respectively, and approximately 85% of the deviations are within ±20%, which is much better than that of the existing generalized correlations.
文摘On February 24, 1993, when the appraisal meeting of the Sino-Japanese Joint Research Project of Well-off Household Residences was held in Beijing, Person-in-charge from the China Building Technology Development and Research Centre and the Japan International Cooperation Undertakings Group signed the project appraisal report. It marked the successful completion of this three-year joint research project.
基金funded by the Special Fund for Fundamental Research of Central-level Public Interest Institutions,China(ZDJ2011-13)
文摘In this study, the North China seismic region was selected as the study area, and evaluation of seismic hazard using the spatial smoothing seismicity model was performed. Firstly, the study area is divided into grids, and some parameters （e. g. b-value, Mo, Me, azimuth and M-L relationship ） for each seismotectonic model were assigned. Secondly, using elliptical smoothing based on a seismotectonic background model, the statistical earthquake incidence rate in each grid is successively calculated. Lastly, the relevant ground motion attenuation relationship is chosen to assess seismic hazard of general sites. The maps for the distribution of horizontal peak ground acceleration with 10% probability of exceedance in 50 years were obtained by using the seismic hazard analysis method based on grid source. This seismicity model simplifies the methodology of probabilistic seismic hazard analysis, especially appropriate for those places where seismic tectonics is not yet clearly known. This method can provide valuable references for seismic zonation and seismic safety assessment for significant engineering projects.
基金Supported by NSFC (No.12031006)Fundamental Research Funds for the Central Universities of China。
文摘We study the Cauchy problem of the Kolmogorov-Fokker-Planck equations and show that the solution enjoys an analytic smoothing effect with L?initial datum for positive time.
基金the National Natural Science Foundation of China(No.11672238)the 111 Project(No.BP0719007)the Shaanxi Province Natural Science Foundation(No.2020JZ-06)for the financial support.
文摘A modified inner-element edge-based smoothed finite element method(IES-FEM)is developed and integrated with ABAQUS using a user-defined element(UEL)in this study.Initially,the smoothing domain discretization of IES-FEM is described and compared with ES-FEM.A practical modification of IES-FEM is then introduced that used the technique employed by ES-FEM for the nodal strain calculation.The differences in the strain computation among ES-FEM,IES-FEM,and FEM are then discussed.The modified IES-FEM exhibited superior performance in displacement and a slight advantage in stress compared to FEM using the same mesh according to the results obtained from both the regular and irregular elements.The robustness of the IES-FEM to severely deformed meshes was also verified.
基金supported by National Key Research and Development Technology Project program(SQ2022YFB2400136).
文摘To enable distributed PV to adapt to variations in power grid strength and achieve stable grid connection while enhancing operational flexibility,it is essential to configure grid-connected inverters with an integrated grid-following control mode,allowing smooth switching between GFL and GFM modes.First,impedance models of GFL and GFM PV energy storage VSG systems were established,and grid stability was analyzed.Second,an online impedance identification method based on voltage fluctuation data screening was proposed to enhance the accuracy of impedance identification.Additionally,a PV energy storage GFM/GFL VSG smooth switching method based on current inner loop compensation was introduced to achieve stable grid-connected operation of distributed photovoltaics under changes in strong and weak power grids.Finally,a grid stability analysis was conducted on the multi-machine parallel PV ESS,and a simulation model of a multi-machine parallel PV ESS based on current inner loop compensation was established for testing.Results showed that,compared to using a single GFM or single GFL control for the PV VSG system,the smooth switching method of multi-machine parallel PV ESS effectively suppresses system resonance under variations in power grid strength,enabling adaptive and stable grid-connected operations of distributed PV.
基金supported by grants from the Natural Science Foundation of Shandong Province,China(Grant Nos.:ZR2019ZD28 and ZR2022QH008)the National Natural Science Foundation of China(Grant Nos.:82270301 and 82200465)+1 种基金China Postdoctoral Science Foundation(Grant No.:2023M731842)Shandong Postdoctoral Science Foundation,China(Grant No.:SDCX-ZG-202203013).
文摘Vein graft(VG)failure(VGF)is associated with VG intimal hyperplasia,which is characterized by abnormal accumulation of vascular smooth muscle cells(VSMCs).Most neointimal VSMCs are derived from pre-existing VSMCs via a process of VSMC phenotypic transition,also known as dedifferentiation.There is increasing evidence to suggest that ginger or its bioactive ingredients may block VSMC dedifferentiation,exerting vasoprotective functions;however,the precise mechanisms have not been fully characterized.Therefore,we investigated the effect of ginger on VSMC phenotypic transition in VG remodeling after transplantation.Ginger significantly inhibited neointimal hyperplasia and promoted lumen(L)opening in a 3-month VG,which was primarily achieved by reducing ferroptotic stress.Ferroptotic stress is a pro-ferroptotic state.Contractile VSMCs did not die but instead gained a proliferative capacity and switched to the secretory type,forming neointima(NI)after vein transplantation.Ginger and its two main vasoprotective ingredients(6-gingerol and 6-shogaol)inhibit VSMC dedifferentiation by reducing ferroptotic stress.Network pharmacology analysis revealed that 6-gingerol inhibits ferroptotic stress by targeting P53,while 6-shogaol inhibits ferroptotic stress by targeting 5-lipoxygenase(Alox5),both promoting ferroptosis.Furthermore,both ingredients co-target peroxisome proliferator-activated receptor gamma(PPARγ),decreasing PPARγ-mediated nicotinamide adenine dinucleotide phosphate(NADPH)oxidase 1(Nox1)expression.Nox1 promotes intracellular reactive oxygen species(ROS)production and directly induces VSMC dedifferentiation.In addition,Nox1 is a ferroptosis-promoting gene that encourages ferroptotic stress production,indirectly leading to VSMC dedifferentiation.Ginger,a natural multi-targeted ferroptotic stress inhibitor,finely and effectively prevents VSMC phenotypic transition and protects against venous injury remodeling.
基金financially supported by the Basic and Applied Basic Research Foundation of Guangdong Province(Grant Nos.2023A1515010890 and 2022A1515240039)the National Natural Science Foundation of China(Grant No.52001071)+4 种基金the Special Fund Competition Allocation Project of Guangdong Science and Technology Innovation Strategy(Grant No.2023A01022)the Non-funded Science and Technology Research Program Project of Zhanjiang(Grant No.2021B01416)Student Innovation Team Project of Guangdong Ocean University(Grant No.CXTD2023012)the Doctor Initiate Projects of Guangdong Ocean University(Grant Nos.060302072103 and R20068)the Marine Youth Talent Innovation Project of Zhanjiang(Grant No.2021E05009).
文摘The interaction between extreme waves and structures is a crucial study area in marine science,as it significantly influences safety and disaster prevention strategies for marine and coastal engineering.To investigate the flow field of a semi-submersible against extreme waves,a model simulating solitary wave interactions with the semi-submersible system was developed via the meshless smoothed particle hydrodynamics(SPH)method and Rayleigh’s theory.Notably,the wave surface and wave load results obtained from the SPH model,compared with those of OpenFOAM,result in an interaction test case between solitary waves and partially submerged rectangular obstacles and show good agreement,with a maximum relative error of 3.4%.An analysis of the calculated results of the semi-submersible facing solitary waves revealed several key findings:overtopping,which decreases with increasing water depth,occurs on the structure when the non-submerged ratio is 0.33 and the wave height surpasses 0.2 m.The transmission coefficient decreases with increasing wave height but increases as the water depth increases.Furthermore,the reflection coefficient peaks at a wave height H0=0.2 m.The dissipation coefficient displays a valley trend with a small water depth,whereas it increases monotonically with increasing water depth.The dissipation coefficient decreases with increasing water depth.
基金supported by the Glocal University 30 Project Fund of Gyeongsang National University in 2025.
文摘Adversarial attacks pose a significant threat to artificial intelligence systems by exposing them to vulnerabilities in deep learning models.Existing defense mechanisms often suffer drawbacks,such as the need for model retraining,significant inference time overhead,and limited effectiveness against specific attack types.Achieving perfect defense against adversarial attacks remains elusive,emphasizing the importance of mitigation strategies.In this study,we propose a defense mechanism that applies random cropping and Gaussian filtering to input images to mitigate the impact of adversarial attacks.First,the image was randomly cropped to vary its dimensions and then placed at the center of a fixed 299299 space,with the remaining areas filled with zero padding.Subsequently,Gaussian×filtering with a 77 kernel and a standard deviation of two was applied using a convolution operation.Finally,the×smoothed image was fed into the classification model.The proposed defense method consistently appeared in the upperright region across all attack scenarios,demonstrating its ability to preserve classification performance on clean images while significantly mitigating adversarial attacks.This visualization confirms that the proposed method is effective and reliable for defending against adversarial perturbations.Moreover,the proposed method incurs minimal computational overhead,making it suitable for real-time applications.Furthermore,owing to its model-agnostic nature,the proposed method can be easily incorporated into various neural network architectures,serving as a fundamental module for adversarial defense strategies.
基金supported by the National Natural Science Foundation of China(Grant 12472113).
文摘The traditional topology optimization method of continuum structure generally uses quadrilateral elements as the basic mesh.This approach often leads to jagged boundary issues,which are traditionally addressed through post-processing,potentially altering the mechanical properties of the optimized structure.A topology optimization method of Movable Morphable Smooth Boundary(MMSB)is proposed based on the idea of mesh adaptation to solve the problem of jagged boundaries and the influence of post-processing.Based on the ICM method,the rational fraction function is introduced as the filtering function,and a topology optimization model with the minimum weight as the objective and the displacement as the constraint is established.A triangular mesh is utilized as the base mesh in this method.The mesh is re-divided in the optimization process based on the contour line,and a smooth boundary parallel to the contour line is obtained.Numerical examples demonstrate that the MMSB method effectively resolves the jagged boundary issues,leading to enhanced structural performance.
基金funded by the Natural Science Foundation of China(NSFC),Grants No.12072048 to M.L.,12272063,and 11532003 to L.D.partially supported by the Science and Technology Innovation Leading Plan of High-Tech Industry in Hunan Province,China,Grant No.2020SK2018 to L.D.
文摘Background:Mechanical ventilation(MV)provides life support for patients with severe respiratory distress but can simultaneously cause ventilator-induced lung injury(VILI).However,due to a poor understanding of its mechanism,there is still a lack of effective remedies for the often-deadly VILI.Recent studies indicate that the stretch associated with MV can enhance the secretion of extracellular vesicles(EVs)and induce endoplasmic reticulum(ER)stress in airway smoothmuscle cells(ASMCs),both of which can contribute to VILI.But whetherMVassociated stretch enhances the secretion of EVs via ER stress in ASMCs as an underlying mechanism of VILI remains unknown.Methods:In this study,we exposed cultured human ASMCs to stretch(13%strain)and mouse models to MV at tidal volume(18 mL/kg).Subsequently,the amount of secreted EVs in the culture medium of ASMCs and the bronchoalveolar lavage fluid(BALF)of mousemodels was quantitatively evaluated by ultracentrifugation,transmission electron microscopy,Western blot,flow cytometry,and nanoparticle tracking analysis.The cultured ASMCs and the lung tissues of mouse models were assessed for expression of biomarkers of EVs(cluster of differentiation antigen 63,CD63),ER stress(heat shock protein family A member 5,HSPA5),and EVs regulating molecule Rab27a by immunofluorescence microscopy,immunohistochemistry(IHC)and enzyme-linked immunosorbent assay(ELISA),respectively.MicroRNAs(miRNAs)in EVs from ASMCs were measured with miRNA whole genome sequencing(miRNA-Seq).Results:We found that stretch enhanced EV secretion from cultured ASMCs.In addition,the cultured ASMCs and the mouse models were either or not pretreated with ER stress inhibitor(tauroursodeoxycholic acid,TUDCA)/EV secretion inhibitor(GW4869)prior to stretch or MV.We found that MV-associated stretch enhanced the expression of CD63,HSPA5,and Rab27a in cultured ASMCs and BALF/lung tissues of mousemodels,which could all be attenuated with TUDCA/GW4869 pretreatment.miRNA-Seq data show that differentially expressed miRNAs in EVsmainlymodulate gene transcription.Furthermore,the EVs fromcultured ASMCs under stretch tended to enhance detachment and expression of inflammatory cytokines,i.e.,transforming growth factor-β1(TGF-β1),interleukin-10(IL-10)in cultured airway epithelial cells.The expression of TGF-β1 and IL-10 in BALF of the mouse models also increased in response to MV,which was attenuated together with partial improvement of lung injury by pretreatment with TUDCA,GW4869/Rab27a siRNAs.Conclusion:Taken together,our data indicate thatMV-associated stretch can enhance the secretion of EVs from ASMCs via ER stress signaling to mediate airway inflammation and VILI,which provides new insight for further exploring EVs for the diagnosis and treatment of VILI.
基金financial support from the National Key Research and Development Program of China(Grant No.2019YFC1509702)the Fundamental Research Funds for the Central Universities in Chinathe National Natural Science Foundation of China(Grant No.42377162).
文摘A discontinuous smoothed particle hydrodynamics(DSPH)method considering block contacts is originally developed to model the cracking,frictional slip and large deformation in rock masses,and is verified by theoretical,numerical and/or experimental results.In the DSPH method,cracking is realized by breaking the virtual bonds via a pseudo-spring method based on Mohr–Coulomb failure criteria.The damaged particles are instantaneously replaced by discontinuous particles and the contact bond between the original and discontinuous particles is formed to simulate the frictional slip and separation/contraction between fracture surfaces based on the block contact algorithm.The motion of rock blocks and the contact force of discontinuous particles are determined following Newton's second law.The results indicate that the DSPH method precisely captures the cracking,contact formation and complete failure across six numerical benchmark tests.This single smoothed particle hydrodynamics(SPH)framework could significantly improve computational efficiency and is potentially applicable to broad multi-physical rock engineering problems of different scales.
基金supported by the financial support from the National Natural Science Foundation of China(No.52172356)Hunan Provincial Natural Science Foundation of China(No.2022JJ10012)。
文摘Topology optimization stands as a pivotal technique in realizing periodic microstructure design.A novel approach is proposed,integrating the energy-based homogenization method with the Floating Projection Topology Optimization(FPTO)method to achieve smooth topology design.The objective is to optimize the periodic microstructure to maximize the properties of specific materials,such as bulk modulus and shear modulus,or to achieve negative Poisson's ratio.Linear material interpolation is used to eliminate the nonlinear challenges and design dependence caused by material penalty.Furthermore,the three-field density representation technique is applied to augment length scales and solid/void characteristics.Through systematic analysis and numerical simulations,the impacts of various initial designs and optimization parameters on the optimization outcomes are investigated.The results demonstrate that the optimized periodic microstructures exhibit extreme performance with clear boundaries.The identification of appropriate optimization parameters is crucial for enhancing the extreme mechanical properties of material microstructures.It can provide valuable guidance for aerospace component design involving material microstructures and metamaterials.
基金supported by the National Natural Science Foundation under Grant 62273189the Shandong Province Natural Science Foundation under Grant ZR2021MF005Systems Science Plus Joint Research Program of Qingdao University under Grant XT2024201 of China supporting this research work.
文摘This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.
基金supported by the NSFC(12071437)the National Key R&D Program of China(2022YFA1005700).
文摘Combining TT* argument and bilinear interpolation,this paper obtains the Strichartz and smoothing estimates of dispersive semigroup e^(-itP(D)) in weighted L^(2) spaces.Among other things,we recover the results in[1].Moreover,the application of these results to the well-posedness of some equations are shown in the last section.
