We assessed the concomitant impact of cigarette smoking and alcohol con sumption in men presenting for primary couple's infertility.Data from 189 in fertile men were an a lyzed.Semen analysis,serum hormones,and sp...We assessed the concomitant impact of cigarette smoking and alcohol con sumption in men presenting for primary couple's infertility.Data from 189 in fertile men were an a lyzed.Semen analysis,serum hormones,and sperm DNA fragmentation(SDF)were obtained.Smoking status was categorized as follows:current nonsmoker(-S),moderate smoker(+MS),and heavy smoker(+HS).Alcohol consumption was categorized as follows:abstainer(-D),moderate drinker(+MD),and heavy drinker(+HD).Descriptive statistics and logistic regression models were applied.Among all the participants,132(69.8%),30(15.9%),and 27(14.3%)patients were-S,+MS,and+HS,respectively.In addition,67(35.4%),77(40.7%)and 45(23.8%)men were-D,+MD and+HD,respectively.Regarding concomitant habits,52(27.5%)patients were nonsmokers and abstainers(-S/-D:Group 1),91(48.1%)had at least one recreational habit(-S/+D or+S/-D:Group 2),and 46(24.3%)were both smokers and drinkers(+S/+D:Group 3).Sperm concentration and progressive motility were lower in+HS and+HD,compared with-S and-D(all P<0.05),respectively.Similarly,both parameters were significantly lower in Group 3 than Groups 1 and 2(all P<0.05).SDF values were higher in Group 3 than Groups 1 and 2(both P<0.05).In multivariate analysis,follicle-stimulating hormone(FSH)levels and concomitant+S/+D status were independent predictors of impaired sperm concentration and progressive motility(all P<0.05).Heavy smoking and heavy drinking were associated with worse seminal parameters than moderate smoking/drinking and nonsmoking/abstaining.When concomitant,+S/+D status has an even greater detrimental effect on semen parameters.展开更多
对不同掺杂量的人工烟水晶 Y 棒和未掺杂水晶 Y 棒 c 面、±x 面作 HF 酸腐蚀,然后进行扫描电镜蚀象形貌观察。观察到 c 面腐蚀后出现的三方锥体和对应的蚀坑与水晶中三方偏方面体单形方位一致。±x 面蚀坑形貌特征进一步表明...对不同掺杂量的人工烟水晶 Y 棒和未掺杂水晶 Y 棒 c 面、±x 面作 HF 酸腐蚀,然后进行扫描电镜蚀象形貌观察。观察到 c 面腐蚀后出现的三方锥体和对应的蚀坑与水晶中三方偏方面体单形方位一致。±x 面蚀坑形貌特征进一步表明了该单形在烟水晶生长中的显露。指出了在±x 这两个面族上蚀坑形貌的方位与晶体内部结构中 Si—O_4四面体在 x 轴方向褶叠螺旋环的旋向一致,使晶体表面形貌与晶体内部结构由表及里有机地联系起来。展开更多
OBJECTIVE: To assess the toxicity of moxa smoke in rats.METHODS: Forty-eight female Wister rats were randomly divided into 4 groups(n = 12/group) to simulate moxa smoke exposure in Chinese medicine clinics(CMCs): the ...OBJECTIVE: To assess the toxicity of moxa smoke in rats.METHODS: Forty-eight female Wister rats were randomly divided into 4 groups(n = 12/group) to simulate moxa smoke exposure in Chinese medicine clinics(CMCs): the control group, and three moxa-smoke exposed groups of PM10 mass concentrations 3-5, 7-9 and 27-30 mg/m^3, respectively.These concentrations were 1 ×, 2-3 ×, and 7-9 ×fold the concentrations found in CMCs. Exposures continued for 12 weeks(200 min/d, 5 d/week).RESULTS: No deaths were noted. After the exposure, the body weights, ratios of organ weight to body weight, urinary parameters, hematological parameters, clinical chemistry parameters and microscopic examinations revealed no obvious toxicity.CONCLUSION: Moxa smoke did not induce toxic effects in female rats in the study. These findings provide new evidence to the toxicity of moxa smoke.展开更多
文摘We assessed the concomitant impact of cigarette smoking and alcohol con sumption in men presenting for primary couple's infertility.Data from 189 in fertile men were an a lyzed.Semen analysis,serum hormones,and sperm DNA fragmentation(SDF)were obtained.Smoking status was categorized as follows:current nonsmoker(-S),moderate smoker(+MS),and heavy smoker(+HS).Alcohol consumption was categorized as follows:abstainer(-D),moderate drinker(+MD),and heavy drinker(+HD).Descriptive statistics and logistic regression models were applied.Among all the participants,132(69.8%),30(15.9%),and 27(14.3%)patients were-S,+MS,and+HS,respectively.In addition,67(35.4%),77(40.7%)and 45(23.8%)men were-D,+MD and+HD,respectively.Regarding concomitant habits,52(27.5%)patients were nonsmokers and abstainers(-S/-D:Group 1),91(48.1%)had at least one recreational habit(-S/+D or+S/-D:Group 2),and 46(24.3%)were both smokers and drinkers(+S/+D:Group 3).Sperm concentration and progressive motility were lower in+HS and+HD,compared with-S and-D(all P<0.05),respectively.Similarly,both parameters were significantly lower in Group 3 than Groups 1 and 2(all P<0.05).SDF values were higher in Group 3 than Groups 1 and 2(both P<0.05).In multivariate analysis,follicle-stimulating hormone(FSH)levels and concomitant+S/+D status were independent predictors of impaired sperm concentration and progressive motility(all P<0.05).Heavy smoking and heavy drinking were associated with worse seminal parameters than moderate smoking/drinking and nonsmoking/abstaining.When concomitant,+S/+D status has an even greater detrimental effect on semen parameters.
文摘对不同掺杂量的人工烟水晶 Y 棒和未掺杂水晶 Y 棒 c 面、±x 面作 HF 酸腐蚀,然后进行扫描电镜蚀象形貌观察。观察到 c 面腐蚀后出现的三方锥体和对应的蚀坑与水晶中三方偏方面体单形方位一致。±x 面蚀坑形貌特征进一步表明了该单形在烟水晶生长中的显露。指出了在±x 这两个面族上蚀坑形貌的方位与晶体内部结构中 Si—O_4四面体在 x 轴方向褶叠螺旋环的旋向一致,使晶体表面形貌与晶体内部结构由表及里有机地联系起来。
基金Supported by National Natural Science Foundation of China:Effect of Moxibustion on"Longevity Gene"SIRT1 Regulation in Aged Mice(No.81403449)Effect of Moxibustion and its Therapeutic Factors on Mitochondrial Energy Metabolism and Apotosis Pathyway in APP/PS1 Transgenic Alzheimer's Disease Mouse Model(No.81574068)+1 种基金Project of Beijing University of Chinese Medicine(2018-JYBZZ-JS009)National Program on Key Basic Research Project(973 Program):the Study of Components and Mecha-nisms of Artemisia and the Product and Moxibustion and Safety Evaluation(No.2009CB522906)
文摘OBJECTIVE: To assess the toxicity of moxa smoke in rats.METHODS: Forty-eight female Wister rats were randomly divided into 4 groups(n = 12/group) to simulate moxa smoke exposure in Chinese medicine clinics(CMCs): the control group, and three moxa-smoke exposed groups of PM10 mass concentrations 3-5, 7-9 and 27-30 mg/m^3, respectively.These concentrations were 1 ×, 2-3 ×, and 7-9 ×fold the concentrations found in CMCs. Exposures continued for 12 weeks(200 min/d, 5 d/week).RESULTS: No deaths were noted. After the exposure, the body weights, ratios of organ weight to body weight, urinary parameters, hematological parameters, clinical chemistry parameters and microscopic examinations revealed no obvious toxicity.CONCLUSION: Moxa smoke did not induce toxic effects in female rats in the study. These findings provide new evidence to the toxicity of moxa smoke.
