Rock fracture warning is one of the significant challenges in rock mechanics.Many true triaxial and synchronous acoustic emission(AE)tests were conducted on granite samples.The investigation focused on the characteris...Rock fracture warning is one of the significant challenges in rock mechanics.Many true triaxial and synchronous acoustic emission(AE)tests were conducted on granite samples.The investigation focused on the characteristics of AE signals preceding granite fracture,based on the critical slowing down(CSD)theory.The granite undergoes a transition from the stable phase to the fracture phase and exhibits a clear CSD phenomenon,characterized by a pronounced increase in variance and autocorrelation coefficient.The variance mutation points were found to be more identifiable and suitable as the primary criterion for predicting precursor information related to granite fracture,compared to the autocorrelation coefficient.It is noteworthy to emphasize that the CSD factor holds greater potential in elucidating the underlying mechanisms responsible for the critical transition of granite fracture,in comparison to the AE timing parameters.Furthermore,a novel multi-parameter collaborative prediction method for rock fracture was developed by comprehensively analyzing predictive information,including abnormal variation modes and the CSD factor of AE characteristic parameters.This method enhances the understanding and prediction of rock fracture-related geohazards.展开更多
This paper uses the implicit Monte–Carlo full-orbit-following parallel program ISSDE to calculate the prompt loss and slowing down process of neutral beam injection(NBI)-generated fast ions due to Coulomb collisions ...This paper uses the implicit Monte–Carlo full-orbit-following parallel program ISSDE to calculate the prompt loss and slowing down process of neutral beam injection(NBI)-generated fast ions due to Coulomb collisions in the equilibrium configuration of Experimental Advanced Superconducting Tokamak(EAST).This program is based on the weak equivalence of the Fokker–Planck equation under Rosenbluth Mac Donald Judd(RMJ)potential and Stratonovich stochastic differential equation(SDE).The prompt loss with the LCFS boundary and the first wall(FW)boundary of the two co-current neutral injection beams are studied.Simulation results indicate that the loss behavior of fast ions using the FW boundary is very different from that of the LCFS boundary,especially for fast ions with a large gyration radius.According to our calculations,about 5.11%of fast ions generated by perpendicular injection drift out of the LCFS and then return inside the LCFS to be captured by the magnetic field.The prompt loss ratio of fast ions and the ratio of orbital types depend on the initial distribution of fast ions in the Pζ–Λspace.Under the effect of Coulomb collisions,the pitch-angle scattering and stochastic diffusion happens,which will cause more fast ion loss.For short time scales,among the particles lost due to collisions,the fraction of banana ions reaches 92.31%in the perpendicular beam and 58.65%in the tangential beam when the fraction of banana ions in the tangential beam is 3.4%of the total ions,which means that the effect of Coulomb collisions on banana fast ions is more significant.For long time scales,the additional fast ion loss caused by Coulomb collisions of tangential and perpendicular beams accounted for 16.21%and 25.05%of the total particles,respectively.We have also investigated the slowing down process of NBI fast ions.展开更多
There are numerous published theories that cover the different biological processes relating to ageing. No one seems to have integrated such complex and seemingly unrelated information into a holistic framework that e...There are numerous published theories that cover the different biological processes relating to ageing. No one seems to have integrated such complex and seemingly unrelated information into a holistic framework that explains in simple terms the key aspects of ageing and provides a set of daily practices for staying young and healthy. An atiempt is made here to select a 6-dimensional framework symbolized by heart, mind, passion, focus, body and health, and correlate it to the mental, emotional, physical and health aspects of ageing. Based on grounded theory, this paper empirically correlates 30 practical methods that can be used to develop all six dimensions, with 18 key factors that were found to infl uence ageing: Neurogenesis;Epigenetic reprogramming;Removing dying cells;Mitochondria resuscitation;Calorie restriction;Plant-based diet;Regular physical activity;Chi Kung (Qigong);Overcoming anxiety, depression and stress;Positive mind-set;Some worrying;Vitamins and minerals;L-Theanine;Omega-3 and healthy fats;Coenzyme Q-10;Pyrroloquinoline quinone;Nitric oxide;Choline. In this study, 26 references were used to establish that all 18 of these seemingly unrelated key anti-ageing factors can be developed using 30 daily practices derived from the 6-dimensional framework. These simple daily prac-tices can help people of all ages to stay young and healthy, and help older people who are living alone to self-improve their quality of life without needing anyone to look atier them. Since many anti-ageing drugs seem to be ineffective, this study provides a holistic new research direction for using modern science and ancient human energy practices combined with wholesome nutrition to slow ageing and age-related illnesses.展开更多
We study the critical slowing down phenomenon in deformation and groundwater observations before the Nilka-Gongliu MS6. 0 earthquake on November 1, 2011 and Xinyuan-Hejing M S6. 6 earthquake on June 30,2012. Firstly,w...We study the critical slowing down phenomenon in deformation and groundwater observations before the Nilka-Gongliu MS6. 0 earthquake on November 1, 2011 and Xinyuan-Hejing M S6. 6 earthquake on June 30,2012. Firstly,we remove the annual variation and tendency change of basic data by means of wavelet transform analysis.Secondly,we calculate the autocorrelation coefficients and variance of the critical slowing down phenomenon. Lastly,we try to verify the critical slowing down phenomenon before an earthquake. The result indicates that there was obvious critical slowing down of the records at different stations before earthquakes.展开更多
Is the American economy slowing or growing?WallStreet and Corporate America have different views.FederalReserve Chairman Alan Greespan told Congress that it looksas if the economy is slowing.As real retail sales。
Stochastic perturbations and periodic excitations are generally regarded as sources to induce critical transitions in complex systems. However, we find that they are also able to slow down an imminent critical transit...Stochastic perturbations and periodic excitations are generally regarded as sources to induce critical transitions in complex systems. However, we find that they are also able to slow down an imminent critical transition. To illustrate this phenomenon, a periodically driven bistable eutrophication model with Gaussian white noise is introduced as a prototype class of real systems.The residence probability(RP) is presented to measure the possibility that the given system stays in the oligotrophic state versus Gaussian white noise and periodic force. Variations in the mean first passage time(MFPT) and the mean velocity(MV) of the first right-crossing process are also calculated respectively. We show that the frequency of the periodic force can increase the MFPT while reduce the MV under different control parameters. Nevertheless, the noise intensity or the amplitude may result in an increase of the RP only in the case of control parameters approaching the critical values. Furthermore, for an impending critical transition, an increase of the RP appears with the interaction between the amplitude and noise intensity or the combination of the noise intensity and frequency, while the interaction of the frequency and amplitude leads to an extension of the MFPT or a decrease of the MV. As a result, an increase of the RP and MFPT, and a decrease of the MVobtained from our results claim that it is possible to slow down an imminent critical transition via Gaussian white noise and periodic force.展开更多
Here we propose a scheme to slow MgF molecules by using EOM-based frequency-chirped radiation pressure slowing.The scheme well addresses the need for a rapid chirp rate while light molecules are being laser slowed,who...Here we propose a scheme to slow MgF molecules by using EOM-based frequency-chirped radiation pressure slowing.The scheme well addresses the need for a rapid chirp rate while light molecules are being laser slowed,whose scattering rate and recoil velocity are large.Two EOMs are used to compensate the rapidly changing Doppler shifts arised from the movement of molecules,and to cover the hyperfine energy structure of MgF,respectively.Based the scattering rate maps calculated from an optical Bloch equation model,individual molecule trajectories are simulated by using a semi-classical three-dimensional Monte Carlo approach.We show how the modulation configuration of EOM and the magnetic field influence the slowing results.The study shows that a cryogenic buffer gas-cooled MgF beam source is possible to be slowed down with a number of∼1.4×10^(6)–10^(7),and the final forward speed peaks at∼10 m/s near the capture velocity of a molecular MOT.展开更多
A slower pace of life has become fashionable to more urbanites Life was almost all work and no play for Shi Ming,a 40-something worker at a research institute in Beijing,before a heart attack two years ago.
The Geneva-based WTO,in a statement said world trade growth would likely moderate to 6.5% this year from 2010’s "record-breaking" 14.5% expansion.The sharp rise in trade volumes last
The aging global population is driving an increase in dementia,making the early identification of at-risk individuals crucial.Studies have shown that elderly people often exhibit a slowing gait before dementia diagnos...The aging global population is driving an increase in dementia,making the early identification of at-risk individuals crucial.Studies have shown that elderly people often exhibit a slowing gait before dementia diagnosis,which is linked to cognitive decline and predicts dementia risk.With 30%of those over 65 years of age experiencing falls annually,managing fall risk is essential.Motoric cognitive risk syndrome(MCR),characterized by subjective memory impairment and slow gait,is a pre-dementia condition that can identify high-risk individuals without extensive evaluation.The prevalence of MCR varies globally and is associated with an increased risk of falls,disability,and death.Early screening and intervention for MCR can delay dementia and improve fall regulation,offering a new perspective on elderly health management.This review synthesizes the current understanding of MCR-related falls,evaluates risk assessment methods,and discusses health strategies to provide a theoretical basis for fall prevention in community-dwelling older adults.展开更多
Constant rise of oilprices in 20061.The output growth of crude oilpresents a declining trendThe output of crude oil in China in-creased again in 2006.It reached anall-time high monthly output of 15.736million tons in ...Constant rise of oilprices in 20061.The output growth of crude oilpresents a declining trendThe output of crude oil in China in-creased again in 2006.It reached anall-time high monthly output of 15.736million tons in July 2006.Due to therestriction of resources,however,thegrowth of crude oil production展开更多
BACKGROUND The development of slow transit constipation(STC)is associated with intestinal barrier damage.Huangqi decoction(HQD)is effective in treating STC,but me-chanisms are unclear.AIM To investigate whether HQD al...BACKGROUND The development of slow transit constipation(STC)is associated with intestinal barrier damage.Huangqi decoction(HQD)is effective in treating STC,but me-chanisms are unclear.AIM To investigate whether HQD alleviates STC by downregulating the nuclear factorκB(NF-κB)signaling pathway and restoring intestinal barrier function.METHODS KM mice were divided into control,model,and HQD treatment groups.Fresh colonic tissues were collected for single-cell RNA sequencing and spatial tra-nscriptome sequencing.The expressions of claudin-1,mucin 2,and NF-κB P65 proteins were detected by immunohistochemistry.In vitro experiments evaluated the effects of HQD on the LS174T cell line.RESULTS HQD improved intestinal motility,restored mucosal epithelium function and morphology.Single-cell RNA sequencing and spatial transcriptome sequencing data showed a reduction in goblet cells,decreased mucin 2 secretion,and activated apoptotic pathways in STC mice.The population of intestinal stem cells was reduced,and proliferation along with Wnt/β-catenin pathways were inhibited.STC also altered the distribution of intestinal cell states,increasing immune-associated Enterocyte_C3.Aberrant NF-κB pathway activation was noted across various cell types.After HQD treatment,NF-κB pathway activity was down-regulated,while cell proliferation pathways were up-regulated,alongside an increase in Enterocyte_C1 related to material transport.Immunocytochemical,Western blot,and immunohistochemistry analyses confirmed NF-κB pathway activation in goblet cells of STC mice,with HQD inhibiting this aberrant activation.CONCLUSION STC involves intestinal mucosal barrier damage.HQD may treat STC by suppressing NF-κB signaling in epithelial cells,restoring intestinal epithelial cell function,and promoting mucosal barrier repair.展开更多
Two CoⅡ-based complexes,{[Co(dps)_(2)(N_(3))_(2)]·H_(2)O}_n(1)and[Co(dps)_(2)(N_(3))_(2)]_n(2),show a 1D chain and a 3D network,respectively.The central CoⅡions in the complexes have the same coordination envir...Two CoⅡ-based complexes,{[Co(dps)_(2)(N_(3))_(2)]·H_(2)O}_n(1)and[Co(dps)_(2)(N_(3))_(2)]_n(2),show a 1D chain and a 3D network,respectively.The central CoⅡions in the complexes have the same coordination environment with the[Co(dps)_(4)(N_(3))_(2)]unit.Although the differences in crystal parameters are nearly negligible,their magnetic properties are very different.AC susceptibility data show that 1 behaves as a typical field-induced single-ion magnet(SIM)with the out-of-phase(χ_(M)”)signals,while 2 shows ac signals ofχ_(M)”without peaks even under applied dc filed within our measurement window.Far-IR magneto-spectra(FIRMS)show strong spin-phonon couplings at 0 T in 2,likely making the magnetic relaxation in 2 fast,while the couplings are negligible in 1.Small spin-phonon coupling in 1 likely leads to slower magnetic relaxation,making 1 a SIM.The difference in the properties is due to the structural rigidity of 2 in its 3D network,leading to stronger spin-phonon coupling.Combined high-field EPR(HF-EPR)and FIRMS studies give spin-Hamiltonian parameters,including D=64.0(9)cm^(-1),|E|=15.7(2)cm^(-1)for 1 and D=80.0(2)cm^(-1),|E|=19.0(1)cm^(-1)for 2.展开更多
The Mg-Y-Zn magnesium alloy system is known for the presence of Long-Period Stacking Ordered(LPSO)phases that improves strength and ductility with minimal amounts of alloying elements.Even better improvements are asso...The Mg-Y-Zn magnesium alloy system is known for the presence of Long-Period Stacking Ordered(LPSO)phases that improves strength and ductility with minimal amounts of alloying elements.Even better improvements are associated with the specific microstructure known as the Mille-Feuille(MF)structure that can occur in this alloy as well after proper heat treatment.This study systematically compares the traditional ingot metallurgy method with the Bridgman method(slow cooling),coupled with diverse heat treatments and extrusion process.Microscopic analyses reveal variations in the presence of LPSO phases,MF structure,and especially grain size,leading to divergent mechanical and corrosion properties.The Bridgman approach surprisingly stands out,ensuring superior mechanical properties due to kink and texture strengthening.展开更多
Under the perspective of translation aesthetics,the article studies three Chinese-to-English translations of Slow,Slow Tune as research objects,comparing and contrasting the differences between the different translati...Under the perspective of translation aesthetics,the article studies three Chinese-to-English translations of Slow,Slow Tune as research objects,comparing and contrasting the differences between the different translations under the perspective of translation aesthetics.The study finds that:Kenneth Rexroth’s translation is poor in textual understanding,with a lot of errors,and is too shallow in emotional expression,remaining only on the surface of the text;Lin Yutang makes occasional mistakes in understanding individual words,and is able to explore the implicit feelings of the lyricist,and his translation focuses on textual and phonological beauty;Xu Yuanchong’s translation is not only capable of conveying the meaning of the original work,but also of conveying the lyricist’s feelings more vividly and focusing on the phonological beauty.Xu Yuanchong’s translation not only conveys the meaning of the original work,but also vividly conveys the emotion of the lyricist,and pays attention to the beauty of sound.展开更多
High-quality services in today’s mobile networks require stable delivery of bandwidth-intensive network content.Multipath QUIC(MPQUIC),as a multipath protocol that extends QUIC,can utilize multiple paths to support s...High-quality services in today’s mobile networks require stable delivery of bandwidth-intensive network content.Multipath QUIC(MPQUIC),as a multipath protocol that extends QUIC,can utilize multiple paths to support stable and efficient transmission.The standard coupled congestion control algorithm in MPQUIC synchronizes these paths to manage congestion,meeting fairness requirements and improving transmission efficiency.However,current algorithms’Congestion Window(CWND)reduction approach significantly decreases CWND upon packet loss,which lowers effective throughput,regardless of the congestion origin.Furthermore,the uncoupled Slow-Start(SS)in MPQUIC leads to independent exponential CWND growth on each path,potentially causing buffer overflow.To address these issues,we propose the CC-OLIA,which incorporates Packet Loss Classifcation(PLC)and Coupled Slow-Start(CSS).The PLC distinguishes between congestion-induced and random packet losses,adjusting CWND reduction accordingly to maintain throughput.Concurrently,the CSS module coordinates CWND growth during the SS,preventing abrupt increases.Implementation on MININET shows that CC-OLIA not only maintains fair performance but also enhances transmission efficiency across diverse network conditions.展开更多
Laboratory and field observations have suggested a correlation between contact dynamics and slow dynamics.The underlying mechanical mechanisms at the contact level require investigation at the nanoscale.This study use...Laboratory and field observations have suggested a correlation between contact dynamics and slow dynamics.The underlying mechanical mechanisms at the contact level require investigation at the nanoscale.This study uses molecular dynamics(MD)simulations to investigate the interactions between two quartz plates separated by a water film,focusing on the relationship between adhesion force and separation distance.The density and orientation angle profiles were calculated from simulation data to investigate the relationship between the interfacial structure of the water film and contact potential.The simulations reveal multiple metastable states of the contact potential,consistent with existing theoretical models.The results show that the contact force is influenced by the structure of the water film,including oscillation forces and stratification.This provided verification and development for existing theoretical models based on metastable contacts.展开更多
The March 11,2011,MW9.0 Tohoku-Oki earthquake,in Japan,caused rapid strain release near the epicenter,while the Boso Peninsula,located farther away,experienced stress redistribution,leading to changes in the recurrenc...The March 11,2011,MW9.0 Tohoku-Oki earthquake,in Japan,caused rapid strain release near the epicenter,while the Boso Peninsula,located farther away,experienced stress redistribution,leading to changes in the recurrence interval of slow slip events(SSEs)and regional strain.This study focuses on three detected post-2011 Boso SSEs,utilizing a segmented model displacement time series measured by Global Navigation Satellite System(GNSS)to calculate velocity and strain rate fields for eight periods before,during,and after the SSEs.Results show that the 2011 earthquake and the three SSEs significantly alter the velocity field in the Boso region,with SSE velocities predominantly oriented southeast,reaching maximum values of 26.9 cm/a,10.6 cm/a,and 38.5 cm/adnearly opposite to non-SSE periods.After the third SSE,the velocity field nearly returns to its pre-earthquake state,with a maximum of 1.8 cm/a.The maximum shear strain rates during the three SSEs are 25.88×10^(-7) a^(-1),11.38×10^(-7) a^(-1),and 29.02×10^(-7) a^(-1)(i.e.,per annum),significantly higher than those during non-slow slip periods,with principal strain rates following a similar pattern.The spatial distribution of strain rates during the SSEs indicates greater deformation compared to the non-slip periods,dominated by northwest-southeast extension and southwest-northeast compression.Spatiotemporal analysis reveals a strong correlation between seismic frequency and strain rate during the SSEs,with time correlation coefficients of 0.85,0.88,and 0.9.Although larger accumulated strain results in stronger strain release during the latter two SSEs,not all strain is fully released,suggesting that earthquake swarms accompanying the SSEs may contribute to the partial release of unreleased strain.This study,through the analysis of GNSS data,evaluates the spatiotemporal distribution of strain fields during periodic SSEs,contributing to further research on strain accumulation and release,and aiding in the analysis of this regional seismic activity.展开更多
Abuse of amphetamine-based stimulants is a primary public health concern.Recent studies have underscored a troubling escalation in the inappropriate use of prescription amphetamine-based stimulants.However,the neuroph...Abuse of amphetamine-based stimulants is a primary public health concern.Recent studies have underscored a troubling escalation in the inappropriate use of prescription amphetamine-based stimulants.However,the neurophysiological mechanisms underlying the impact of acute methamphetamine exposure(AME)on sleep homeostasis remain to be explored.This study employed non-human primates and electroencephalogram(EEG)sleep staging to evaluate the influence of AME on neural oscillations.The primary focus was on alterations in spindles,delta oscillations,and slow oscillations(SOs)and their interactions as conduits through which AME influences sleep stability.AME predominantly diminishes sleep-spindle waves in the non-rapid eye movement 2(NREM2)stage,and impacts SOs and delta waves differentially.Furthermore,the competitive relationships between SO/delta waves nesting with sleep spindles were selectively strengthened by methamphetamine.Complexity analysis also revealed that the SO-nested spindles had lost their ability to maintain sleep depth and stability.In summary,this finding could be one of the intrinsic electrophysiological mechanisms by which AME disrupted sleep homeostasis.展开更多
A kind of slow deformation wave is produced in the crust under the action of internal and external factors,which plays an important role in the formation and occurrence of earthquakes.In this paper,uniaxial compressio...A kind of slow deformation wave is produced in the crust under the action of internal and external factors,which plays an important role in the formation and occurrence of earthquakes.In this paper,uniaxial compression tests are carried out on red sandstone samples with uniform texture.Displacement controlled loading methods are adopted,and the loading rates are 0.1 mm/min,0.5 mm/min and 1.0 mm/min,respectively.The micro-characterization method of speckle photography and DIC processing technology are adopted.The transfer characteristics of slow deformation and strain localization of red sandstone specimens during loading and deformation are discussed.The results show that the boundary advance velocity is proportional to the slow deformation transfer velocity with the change of position,so it can be considered that the slow deformation transfer velocity is equal to the particle motion transfer velocity.The formation and development of sample strain localization may be determined by the flow channel,nucleation and Luders zone evolution.The formation of the Luders band is related to the maximum value of the flow channel,and as deformation increases,the Luders band merges and develops with the maximum value of the nearby flow channel.By applying different loading rates,the influence of loading rate on the average transfer velocity of slow deformation was obtained;the slow deformation wave during seismic migration has similar characteristics to the deformation transfer in the experiment,therefore the research results have reference significance for further studies on the evolution characteristics of slow deformation waves and seismic migration.展开更多
基金Project(52074294)supported by the National Natural Science Foundation of ChinaProject(2022YJSNY16)supported by the Fundamental Research Funds for the Central Universities,China。
文摘Rock fracture warning is one of the significant challenges in rock mechanics.Many true triaxial and synchronous acoustic emission(AE)tests were conducted on granite samples.The investigation focused on the characteristics of AE signals preceding granite fracture,based on the critical slowing down(CSD)theory.The granite undergoes a transition from the stable phase to the fracture phase and exhibits a clear CSD phenomenon,characterized by a pronounced increase in variance and autocorrelation coefficient.The variance mutation points were found to be more identifiable and suitable as the primary criterion for predicting precursor information related to granite fracture,compared to the autocorrelation coefficient.It is noteworthy to emphasize that the CSD factor holds greater potential in elucidating the underlying mechanisms responsible for the critical transition of granite fracture,in comparison to the AE timing parameters.Furthermore,a novel multi-parameter collaborative prediction method for rock fracture was developed by comprehensively analyzing predictive information,including abnormal variation modes and the CSD factor of AE characteristic parameters.This method enhances the understanding and prediction of rock fracture-related geohazards.
基金the National MCF Energy Research and Development Program(Grant No.2018YFE0304100)the National Key Research and Development Program of China(Grant Nos.2016YFA0400600,2016YFA0400601,2016YFA0400602,and 2019YFE0302004)the National Natural Science Foundation of China(Grant Nos.11805273 and 11905220)。
文摘This paper uses the implicit Monte–Carlo full-orbit-following parallel program ISSDE to calculate the prompt loss and slowing down process of neutral beam injection(NBI)-generated fast ions due to Coulomb collisions in the equilibrium configuration of Experimental Advanced Superconducting Tokamak(EAST).This program is based on the weak equivalence of the Fokker–Planck equation under Rosenbluth Mac Donald Judd(RMJ)potential and Stratonovich stochastic differential equation(SDE).The prompt loss with the LCFS boundary and the first wall(FW)boundary of the two co-current neutral injection beams are studied.Simulation results indicate that the loss behavior of fast ions using the FW boundary is very different from that of the LCFS boundary,especially for fast ions with a large gyration radius.According to our calculations,about 5.11%of fast ions generated by perpendicular injection drift out of the LCFS and then return inside the LCFS to be captured by the magnetic field.The prompt loss ratio of fast ions and the ratio of orbital types depend on the initial distribution of fast ions in the Pζ–Λspace.Under the effect of Coulomb collisions,the pitch-angle scattering and stochastic diffusion happens,which will cause more fast ion loss.For short time scales,among the particles lost due to collisions,the fraction of banana ions reaches 92.31%in the perpendicular beam and 58.65%in the tangential beam when the fraction of banana ions in the tangential beam is 3.4%of the total ions,which means that the effect of Coulomb collisions on banana fast ions is more significant.For long time scales,the additional fast ion loss caused by Coulomb collisions of tangential and perpendicular beams accounted for 16.21%and 25.05%of the total particles,respectively.We have also investigated the slowing down process of NBI fast ions.
文摘There are numerous published theories that cover the different biological processes relating to ageing. No one seems to have integrated such complex and seemingly unrelated information into a holistic framework that explains in simple terms the key aspects of ageing and provides a set of daily practices for staying young and healthy. An atiempt is made here to select a 6-dimensional framework symbolized by heart, mind, passion, focus, body and health, and correlate it to the mental, emotional, physical and health aspects of ageing. Based on grounded theory, this paper empirically correlates 30 practical methods that can be used to develop all six dimensions, with 18 key factors that were found to infl uence ageing: Neurogenesis;Epigenetic reprogramming;Removing dying cells;Mitochondria resuscitation;Calorie restriction;Plant-based diet;Regular physical activity;Chi Kung (Qigong);Overcoming anxiety, depression and stress;Positive mind-set;Some worrying;Vitamins and minerals;L-Theanine;Omega-3 and healthy fats;Coenzyme Q-10;Pyrroloquinoline quinone;Nitric oxide;Choline. In this study, 26 references were used to establish that all 18 of these seemingly unrelated key anti-ageing factors can be developed using 30 daily practices derived from the 6-dimensional framework. These simple daily prac-tices can help people of all ages to stay young and healthy, and help older people who are living alone to self-improve their quality of life without needing anyone to look atier them. Since many anti-ageing drugs seem to be ineffective, this study provides a holistic new research direction for using modern science and ancient human energy practices combined with wholesome nutrition to slow ageing and age-related illnesses.
基金sponsored by the Earthquake Science Foundation of Xinjiang,China(201105)
文摘We study the critical slowing down phenomenon in deformation and groundwater observations before the Nilka-Gongliu MS6. 0 earthquake on November 1, 2011 and Xinyuan-Hejing M S6. 6 earthquake on June 30,2012. Firstly,we remove the annual variation and tendency change of basic data by means of wavelet transform analysis.Secondly,we calculate the autocorrelation coefficients and variance of the critical slowing down phenomenon. Lastly,we try to verify the critical slowing down phenomenon before an earthquake. The result indicates that there was obvious critical slowing down of the records at different stations before earthquakes.
文摘Is the American economy slowing or growing?WallStreet and Corporate America have different views.FederalReserve Chairman Alan Greespan told Congress that it looksas if the economy is slowing.As real retail sales。
基金supported by the National Natural Science Foundation of China(Grant Nos.11772255&11872305)the Fundamental Research Funds for the Central Universities+2 种基金Shaanxi Province Project for Distinguished Young ScholarsInnovation Foundation for Doctor Dissertation of Northwestern Polytechnical Universitythe China Postdoctoral Science Foundation
文摘Stochastic perturbations and periodic excitations are generally regarded as sources to induce critical transitions in complex systems. However, we find that they are also able to slow down an imminent critical transition. To illustrate this phenomenon, a periodically driven bistable eutrophication model with Gaussian white noise is introduced as a prototype class of real systems.The residence probability(RP) is presented to measure the possibility that the given system stays in the oligotrophic state versus Gaussian white noise and periodic force. Variations in the mean first passage time(MFPT) and the mean velocity(MV) of the first right-crossing process are also calculated respectively. We show that the frequency of the periodic force can increase the MFPT while reduce the MV under different control parameters. Nevertheless, the noise intensity or the amplitude may result in an increase of the RP only in the case of control parameters approaching the critical values. Furthermore, for an impending critical transition, an increase of the RP appears with the interaction between the amplitude and noise intensity or the combination of the noise intensity and frequency, while the interaction of the frequency and amplitude leads to an extension of the MFPT or a decrease of the MV. As a result, an increase of the RP and MFPT, and a decrease of the MVobtained from our results claim that it is possible to slow down an imminent critical transition via Gaussian white noise and periodic force.
基金supports are from the National Natural Science Foundation of China under Grant Nos.11834003,91836103,and 91536218.
文摘Here we propose a scheme to slow MgF molecules by using EOM-based frequency-chirped radiation pressure slowing.The scheme well addresses the need for a rapid chirp rate while light molecules are being laser slowed,whose scattering rate and recoil velocity are large.Two EOMs are used to compensate the rapidly changing Doppler shifts arised from the movement of molecules,and to cover the hyperfine energy structure of MgF,respectively.Based the scattering rate maps calculated from an optical Bloch equation model,individual molecule trajectories are simulated by using a semi-classical three-dimensional Monte Carlo approach.We show how the modulation configuration of EOM and the magnetic field influence the slowing results.The study shows that a cryogenic buffer gas-cooled MgF beam source is possible to be slowed down with a number of∼1.4×10^(6)–10^(7),and the final forward speed peaks at∼10 m/s near the capture velocity of a molecular MOT.
文摘A slower pace of life has become fashionable to more urbanites Life was almost all work and no play for Shi Ming,a 40-something worker at a research institute in Beijing,before a heart attack two years ago.
文摘The Geneva-based WTO,in a statement said world trade growth would likely moderate to 6.5% this year from 2010’s "record-breaking" 14.5% expansion.The sharp rise in trade volumes last
文摘The aging global population is driving an increase in dementia,making the early identification of at-risk individuals crucial.Studies have shown that elderly people often exhibit a slowing gait before dementia diagnosis,which is linked to cognitive decline and predicts dementia risk.With 30%of those over 65 years of age experiencing falls annually,managing fall risk is essential.Motoric cognitive risk syndrome(MCR),characterized by subjective memory impairment and slow gait,is a pre-dementia condition that can identify high-risk individuals without extensive evaluation.The prevalence of MCR varies globally and is associated with an increased risk of falls,disability,and death.Early screening and intervention for MCR can delay dementia and improve fall regulation,offering a new perspective on elderly health management.This review synthesizes the current understanding of MCR-related falls,evaluates risk assessment methods,and discusses health strategies to provide a theoretical basis for fall prevention in community-dwelling older adults.
文摘Constant rise of oilprices in 20061.The output growth of crude oilpresents a declining trendThe output of crude oil in China in-creased again in 2006.It reached anall-time high monthly output of 15.736million tons in July 2006.Due to therestriction of resources,however,thegrowth of crude oil production
基金Supported by the Natural Science Foundation of Guangdong Province for Distinguished Young Scholars,No.2022B1515020003the National Natural Science Foundation of China,No.82174369,No.82405397,No.82374442,and No.81973847+2 种基金Postdoctoral Fellowship Program of CPSF No.GZC20233247National Key Clinical Disciplineand the Program of Guangdong Provincial Clinical Research Center for Digestive Diseases,No.2020B1111170004.
文摘BACKGROUND The development of slow transit constipation(STC)is associated with intestinal barrier damage.Huangqi decoction(HQD)is effective in treating STC,but me-chanisms are unclear.AIM To investigate whether HQD alleviates STC by downregulating the nuclear factorκB(NF-κB)signaling pathway and restoring intestinal barrier function.METHODS KM mice were divided into control,model,and HQD treatment groups.Fresh colonic tissues were collected for single-cell RNA sequencing and spatial tra-nscriptome sequencing.The expressions of claudin-1,mucin 2,and NF-κB P65 proteins were detected by immunohistochemistry.In vitro experiments evaluated the effects of HQD on the LS174T cell line.RESULTS HQD improved intestinal motility,restored mucosal epithelium function and morphology.Single-cell RNA sequencing and spatial transcriptome sequencing data showed a reduction in goblet cells,decreased mucin 2 secretion,and activated apoptotic pathways in STC mice.The population of intestinal stem cells was reduced,and proliferation along with Wnt/β-catenin pathways were inhibited.STC also altered the distribution of intestinal cell states,increasing immune-associated Enterocyte_C3.Aberrant NF-κB pathway activation was noted across various cell types.After HQD treatment,NF-κB pathway activity was down-regulated,while cell proliferation pathways were up-regulated,alongside an increase in Enterocyte_C1 related to material transport.Immunocytochemical,Western blot,and immunohistochemistry analyses confirmed NF-κB pathway activation in goblet cells of STC mice,with HQD inhibiting this aberrant activation.CONCLUSION STC involves intestinal mucosal barrier damage.HQD may treat STC by suppressing NF-κB signaling in epithelial cells,restoring intestinal epithelial cell function,and promoting mucosal barrier repair.
基金supported by the National Key Research and Development Program of China(No.2021YFA1600304)Joint Fund for Regional Innovation and Development(No.U20A2073)+4 种基金National Natural Science Foundation of China(Nos.22373048,21973038,61904119 and 22105089)Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry(No.20212BCD42018)US National Science Foundation(NSF,No.CHE-2055499)the Interdisciplinary program of Wuhan National High Magnetic Field Center(No.WHMFC202133)the support of the NSF Research Traineeship Program(No.DGE-2152168)。
文摘Two CoⅡ-based complexes,{[Co(dps)_(2)(N_(3))_(2)]·H_(2)O}_n(1)and[Co(dps)_(2)(N_(3))_(2)]_n(2),show a 1D chain and a 3D network,respectively.The central CoⅡions in the complexes have the same coordination environment with the[Co(dps)_(4)(N_(3))_(2)]unit.Although the differences in crystal parameters are nearly negligible,their magnetic properties are very different.AC susceptibility data show that 1 behaves as a typical field-induced single-ion magnet(SIM)with the out-of-phase(χ_(M)”)signals,while 2 shows ac signals ofχ_(M)”without peaks even under applied dc filed within our measurement window.Far-IR magneto-spectra(FIRMS)show strong spin-phonon couplings at 0 T in 2,likely making the magnetic relaxation in 2 fast,while the couplings are negligible in 1.Small spin-phonon coupling in 1 likely leads to slower magnetic relaxation,making 1 a SIM.The difference in the properties is due to the structural rigidity of 2 in its 3D network,leading to stronger spin-phonon coupling.Combined high-field EPR(HF-EPR)and FIRMS studies give spin-Hamiltonian parameters,including D=64.0(9)cm^(-1),|E|=15.7(2)cm^(-1)for 1 and D=80.0(2)cm^(-1),|E|=19.0(1)cm^(-1)for 2.
基金supported by Japan Society for the Promotion of Science(KAKENHI Grant-in-Aid for Scientific Research,18H05475,18H05476 and JP20H00312)MRC International Collaborative Research Grant+4 种基金The authors would like to thank the Czech Science Foundation(Project No.22-22248S)specific university research(A1_FCHT_2024_007)for financial supportsupported by the Ministry of Education,Youth,and Sports of the Czech Republic.Project No.CZ.02.01.01/00/22_008/0004591co-funded by the European UnionCzechNanoLab project LM2023051 funded by MEYS CR is gratefully acknowledged for the financial support of the measurements/sample fabrication at LNSM Research Infrastructure。
文摘The Mg-Y-Zn magnesium alloy system is known for the presence of Long-Period Stacking Ordered(LPSO)phases that improves strength and ductility with minimal amounts of alloying elements.Even better improvements are associated with the specific microstructure known as the Mille-Feuille(MF)structure that can occur in this alloy as well after proper heat treatment.This study systematically compares the traditional ingot metallurgy method with the Bridgman method(slow cooling),coupled with diverse heat treatments and extrusion process.Microscopic analyses reveal variations in the presence of LPSO phases,MF structure,and especially grain size,leading to divergent mechanical and corrosion properties.The Bridgman approach surprisingly stands out,ensuring superior mechanical properties due to kink and texture strengthening.
文摘Under the perspective of translation aesthetics,the article studies three Chinese-to-English translations of Slow,Slow Tune as research objects,comparing and contrasting the differences between the different translations under the perspective of translation aesthetics.The study finds that:Kenneth Rexroth’s translation is poor in textual understanding,with a lot of errors,and is too shallow in emotional expression,remaining only on the surface of the text;Lin Yutang makes occasional mistakes in understanding individual words,and is able to explore the implicit feelings of the lyricist,and his translation focuses on textual and phonological beauty;Xu Yuanchong’s translation is not only capable of conveying the meaning of the original work,but also of conveying the lyricist’s feelings more vividly and focusing on the phonological beauty.Xu Yuanchong’s translation not only conveys the meaning of the original work,but also vividly conveys the emotion of the lyricist,and pays attention to the beauty of sound.
文摘High-quality services in today’s mobile networks require stable delivery of bandwidth-intensive network content.Multipath QUIC(MPQUIC),as a multipath protocol that extends QUIC,can utilize multiple paths to support stable and efficient transmission.The standard coupled congestion control algorithm in MPQUIC synchronizes these paths to manage congestion,meeting fairness requirements and improving transmission efficiency.However,current algorithms’Congestion Window(CWND)reduction approach significantly decreases CWND upon packet loss,which lowers effective throughput,regardless of the congestion origin.Furthermore,the uncoupled Slow-Start(SS)in MPQUIC leads to independent exponential CWND growth on each path,potentially causing buffer overflow.To address these issues,we propose the CC-OLIA,which incorporates Packet Loss Classifcation(PLC)and Coupled Slow-Start(CSS).The PLC distinguishes between congestion-induced and random packet losses,adjusting CWND reduction accordingly to maintain throughput.Concurrently,the CSS module coordinates CWND growth during the SS,preventing abrupt increases.Implementation on MININET shows that CC-OLIA not only maintains fair performance but also enhances transmission efficiency across diverse network conditions.
文摘Laboratory and field observations have suggested a correlation between contact dynamics and slow dynamics.The underlying mechanical mechanisms at the contact level require investigation at the nanoscale.This study uses molecular dynamics(MD)simulations to investigate the interactions between two quartz plates separated by a water film,focusing on the relationship between adhesion force and separation distance.The density and orientation angle profiles were calculated from simulation data to investigate the relationship between the interfacial structure of the water film and contact potential.The simulations reveal multiple metastable states of the contact potential,consistent with existing theoretical models.The results show that the contact force is influenced by the structure of the water film,including oscillation forces and stratification.This provided verification and development for existing theoretical models based on metastable contacts.
基金funded by the National Natural Science Foundation of China(41704031,42374040)the Natural Science Foundation of Jiangxi Science and Technology Department(20232BAB203073)the Key Laboratory of Mine Environmental Monitoring and Improving around Poyang Lake,Ministry of Natural Resources(MEMI-2021-2022-29).
文摘The March 11,2011,MW9.0 Tohoku-Oki earthquake,in Japan,caused rapid strain release near the epicenter,while the Boso Peninsula,located farther away,experienced stress redistribution,leading to changes in the recurrence interval of slow slip events(SSEs)and regional strain.This study focuses on three detected post-2011 Boso SSEs,utilizing a segmented model displacement time series measured by Global Navigation Satellite System(GNSS)to calculate velocity and strain rate fields for eight periods before,during,and after the SSEs.Results show that the 2011 earthquake and the three SSEs significantly alter the velocity field in the Boso region,with SSE velocities predominantly oriented southeast,reaching maximum values of 26.9 cm/a,10.6 cm/a,and 38.5 cm/adnearly opposite to non-SSE periods.After the third SSE,the velocity field nearly returns to its pre-earthquake state,with a maximum of 1.8 cm/a.The maximum shear strain rates during the three SSEs are 25.88×10^(-7) a^(-1),11.38×10^(-7) a^(-1),and 29.02×10^(-7) a^(-1)(i.e.,per annum),significantly higher than those during non-slow slip periods,with principal strain rates following a similar pattern.The spatial distribution of strain rates during the SSEs indicates greater deformation compared to the non-slip periods,dominated by northwest-southeast extension and southwest-northeast compression.Spatiotemporal analysis reveals a strong correlation between seismic frequency and strain rate during the SSEs,with time correlation coefficients of 0.85,0.88,and 0.9.Although larger accumulated strain results in stronger strain release during the latter two SSEs,not all strain is fully released,suggesting that earthquake swarms accompanying the SSEs may contribute to the partial release of unreleased strain.This study,through the analysis of GNSS data,evaluates the spatiotemporal distribution of strain fields during periodic SSEs,contributing to further research on strain accumulation and release,and aiding in the analysis of this regional seismic activity.
基金supported by the National Natural Science Foundation of China(No.82271515)the SJTU Trans-Med Awards Research(No.2019015)+4 种基金the Scientific and Technological Innovation Action Plan of Shanghai(No.KY20211478)the Shanghai Municipal Science and Technology Major Project(No.2021SHZDZX)the Nursing Development Program of Shanghai Jiao Tong University School of Medicine(No.SJTUHLXK2022)the 2024 Shanghai Ruijin Hospital Nursing Research Fund(No.RJHK-2024-001)the Shanghai Nursing Association Funding(No.2024MS-B13),China。
文摘Abuse of amphetamine-based stimulants is a primary public health concern.Recent studies have underscored a troubling escalation in the inappropriate use of prescription amphetamine-based stimulants.However,the neurophysiological mechanisms underlying the impact of acute methamphetamine exposure(AME)on sleep homeostasis remain to be explored.This study employed non-human primates and electroencephalogram(EEG)sleep staging to evaluate the influence of AME on neural oscillations.The primary focus was on alterations in spindles,delta oscillations,and slow oscillations(SOs)and their interactions as conduits through which AME influences sleep stability.AME predominantly diminishes sleep-spindle waves in the non-rapid eye movement 2(NREM2)stage,and impacts SOs and delta waves differentially.Furthermore,the competitive relationships between SO/delta waves nesting with sleep spindles were selectively strengthened by methamphetamine.Complexity analysis also revealed that the SO-nested spindles had lost their ability to maintain sleep depth and stability.In summary,this finding could be one of the intrinsic electrophysiological mechanisms by which AME disrupted sleep homeostasis.
基金Postdoctoral Science Fund(043201027)National Natural Science Key Foundation of China(41831290)National Natural Science Foundation of China(52079068).
文摘A kind of slow deformation wave is produced in the crust under the action of internal and external factors,which plays an important role in the formation and occurrence of earthquakes.In this paper,uniaxial compression tests are carried out on red sandstone samples with uniform texture.Displacement controlled loading methods are adopted,and the loading rates are 0.1 mm/min,0.5 mm/min and 1.0 mm/min,respectively.The micro-characterization method of speckle photography and DIC processing technology are adopted.The transfer characteristics of slow deformation and strain localization of red sandstone specimens during loading and deformation are discussed.The results show that the boundary advance velocity is proportional to the slow deformation transfer velocity with the change of position,so it can be considered that the slow deformation transfer velocity is equal to the particle motion transfer velocity.The formation and development of sample strain localization may be determined by the flow channel,nucleation and Luders zone evolution.The formation of the Luders band is related to the maximum value of the flow channel,and as deformation increases,the Luders band merges and develops with the maximum value of the nearby flow channel.By applying different loading rates,the influence of loading rate on the average transfer velocity of slow deformation was obtained;the slow deformation wave during seismic migration has similar characteristics to the deformation transfer in the experiment,therefore the research results have reference significance for further studies on the evolution characteristics of slow deformation waves and seismic migration.
