The strength of the sliding zone soil determines the stability of reservoir landslides.Fluctuations in water levels cause a change in the seepage field,which serves as both the external hydrogeological environment and...The strength of the sliding zone soil determines the stability of reservoir landslides.Fluctuations in water levels cause a change in the seepage field,which serves as both the external hydrogeological environment and the internal component of a landslide.Therefore,considering the strength changes of the sliding zone with seepage effects,they correspond with the actual hydrogeological circumstances.To investigate the shear behavior of sliding zone soil under various seepage pressures,24 samples were conducted by a self-developed apparatus to observe the shear strength and measure the permeability coefficients at different deformation stages.After seepage-shear tests,the composition of clay minerals and microscopic structure on the shear surface were analyzed through X-ray and scanning electron microscope(SEM)to understand the coupling effects of seepage on strength.The results revealed that the sliding zone soil exhibited strain-hardening without seepage pressure.However,the introduction of seepage caused a significant reduction in shear strength,resulting in strain-softening characterized by a three-stage process.Long-term seepage action softened clay particles and transported broken particles into effective seepage channels,causing continuous damage to the interior structure and reducing the permeability coefficient.Increased seepage pressure decreased the peak strength by disrupting occlusal and frictional forces between sliding zone soil particles,which carried away more clay particles,contributing to an overhead structure in the soil that raised the permeability coefficient and decreased residual strength.The internal friction angle was less sensitive to variations in seepage pressure than cohesion.展开更多
0 INTRODUCTION Submarine slope slides refer to a geological process occurring on submarine slopes or continental margin slopes,where a large amount of sediment or rock layers on the slope lose stability and slide down...0 INTRODUCTION Submarine slope slides refer to a geological process occurring on submarine slopes or continental margin slopes,where a large amount of sediment or rock layers on the slope lose stability and slide downward along the sliding surface(Kamran et al.,2023;Tong et al.,2023;Hampton et al.,1996).展开更多
Deep-sea pipelines play a pivotal role in seabed mineral resource development,global energy and resource supply provision,network communication,and environmental protection.However,the placement of these pipelines on ...Deep-sea pipelines play a pivotal role in seabed mineral resource development,global energy and resource supply provision,network communication,and environmental protection.However,the placement of these pipelines on the seabed surface exposes them to potential risks arising from the complex deep-sea hydrodynamic and geological environment,particularly submarine slides.Historical incidents have highlighted the substantial damage to pipelines due to slides.Specifically,deep-sea fluidized slides(in a debris/mud flow or turbidity current physical state),characterized by high speed,pose a significant threat.Accurately assessing the impact forces exerted on pipelines by fluidized submarine slides is crucial for ensuring pipeline safety.This study aimed to provide a comprehensive overview of recent advancements in understanding pipeline impact forces caused by fluidized deep-sea slides,thereby identifying key factors and corresponding mechanisms that influence pipeline impact forces.These factors include the velocity,density,and shear behavior of deep-sea fluidized slides,as well as the geometry,stiffness,self-weight,and mechanical model of pipelines.Additionally,the interface contact conditions and spatial relations were examined within the context of deep-sea slides and their interactions with pipelines.Building upon a thorough review of these achievements,future directions were proposed for assessing and characterizing the key factors affecting slide impact loading on pipelines.A comprehensive understanding of these results is essential for the sustainable development of deep-sea pipeline projects associated with seabed resource development and the implementation of disaster prevention measures.展开更多
Landslides occurring in sensitive clay often result in widespread destruction,posing a significant risk to human lives and property due to the substantial decrease in undrained shear strength during deformation.Assess...Landslides occurring in sensitive clay often result in widespread destruction,posing a significant risk to human lives and property due to the substantial decrease in undrained shear strength during deformation.Assessing the consequences of these landslides is challenging and necessitates robust numerical methods to comprehensively investigate their failure mechanisms.While studies have extensively explored upward progressive landslides in sensitive clays,understanding downward progressive cases remains limited.In this study,we utilised the nodal integration-based particle finite element method(NPFEM)with a nonlinear strain-softening model to analyse downward progressive landslides in sensitive clay on elongated slopes,induced by surcharge loads near the crest.We focused on elucidating the underlying failure mechanisms and evaluating the effects of different soil parameters and strainsoftening characteristics.The simulation results revealed the typical pattern for downward landslides,which typically start with a localised failure in proximity to the surcharge loads,followed by a combination of different types of failure mechanisms,including single flow slides,translational progressive landslides,progressive flow slides,and spread failures.Additionally,inclined shear bands occur within spread failures,often adopting distinctive ploughing patterns characterised by triangular shapes.The sensitive clay thickness at the base,the clay strength gradient,the sensitivity,and the softening rate significantly influence the failure mechanisms and the extent of diffused displacement.Remarkably,some of these effects mirror those observed in upward progressive landslides,underscoring the interconnectedness of these phenomena.This study contributes valuable insights into the complex dynamics of sensitive clay landslides,shedding light on the intricate interplay of factors governing their behaviour and progression.展开更多
Background The S4SLIDE project(IGCP-640)builds upon the extremely successful E-MARSHAL and IGCP-511 projects also known as the Submarine Mass Movements and Their Consequences project.S4SLIDE has a broader reach that s...Background The S4SLIDE project(IGCP-640)builds upon the extremely successful E-MARSHAL and IGCP-511 projects also known as the Submarine Mass Movements and Their Consequences project.S4SLIDE has a broader reach that seeks to incorporate learnings from lacustrine,coastal and subaerial landslides.As with its predecessors,the IGCP-640 project focuses on facilitating the interaction of scientists,engineers,industry and government representatives,and other parties interested in subaqueous mass movements and their geohazard potential.展开更多
Background The S4SLIDE project(IGCP-640)builds upon the extremely successful E-MARSHAL and IGCP-511 projects also known as the Submarine Mass Movements and Their Consequences project.S4SLIDE has a broader reach that s...Background The S4SLIDE project(IGCP-640)builds upon the extremely successful E-MARSHAL and IGCP-511 projects also known as the Submarine Mass Movements and Their Consequences project.S4SLIDE has a broader reach that seeks to incorporate learnings from lacustrine,coastal and subaerial landslides.As with its predecessors,the IGCP-640 project focuses on facilitating the interaction of scientists,engineers,industry and government representatives,and other parties interested in subaqueous mass movements and their geohazard potential.展开更多
Loess landslides are one of the most serious geological disasters in the Chinese Loess Plateau.Research has revealed that earthquake,rainfall,and human activities are common triggers for loess landslides.In order to s...Loess landslides are one of the most serious geological disasters in the Chinese Loess Plateau.Research has revealed that earthquake,rainfall,and human activities are common triggers for loess landslides.In order to study the relationship and characteristics of these landslides triggered by different factors,the paper uses historic landslide data to expound the basic motion indices of landslides triggered by different factors.More than half of loess landslides occurred on concave surface slopes,while nearly 40%of the loess landslides occurred on convex surface slopes.Human activities have a great effect on the occurrence of landslides,and the distribution density of landslides on residential land was almost five times that of bare land.Additionally,earthquakeinduced loess landslides had the largest sliding volume,whereas the excavation-induced loess landslide had the smallest sliding volume.The sliding volume of irrigation-induced and rainfall-induced loess landslides were between earthquake-induced loess landslides and excavation-induced loess landslide.Many of loess landslides were induced by a combination of these factors,such as rainfall and excavation,irrigation and excavation.Then a model that described the impact of these factors on the loess landslides was proposed.展开更多
In the past, the pseudo-static method used to be the most common for evaluating the stability of landslides under seismic loads, in which static forces acting on the center of gravity of a sliding body are used to con...In the past, the pseudo-static method used to be the most common for evaluating the stability of landslides under seismic loads, in which static forces acting on the center of gravity of a sliding body are used to consider the effects of earthquake. However, seismic loads of rock and soil differ from time and location to time and location. Obviously, it is irrational for the pseudo-static approach to be applied to solving dynamic problems. In this paper, a displacement- pseudo-dynamic model is proposed to assess seismic stability of landslides, in which the sinusoidal- cosinusoidal wave is applied to simulating earthquake displacement, and an ＂amplification factor＂ of peak seismic displacement is referred to as the amplification of seismic wave when it propagates from the bottom to the top of the landslide. The effects of physico-mechanical behaviors of a sliding body on seismic stability of soil slopes are taken into account as well as inertia forces and damping forces. The sensitivity analyses on the permanent displacement and the dynamic factor of safety of landslides are studied in detail. Moreover, a large-scale Tangjiashan landslide that occurred in Wenchuan earthquake is investigated to verify the robustness and precision of the present method. It is found that the results from the present method is in good agreement with those from the previous method.展开更多
Purpose: To standardize the methods to measure Ki-67, there is an interest in automating the assessment of Ki-67. Therefore, we reviewed the possibility of introducing an automated analyzer to standardize the Ki-67 ev...Purpose: To standardize the methods to measure Ki-67, there is an interest in automating the assessment of Ki-67. Therefore, we reviewed the possibility of introducing an automated analyzer to standardize the Ki-67 evaluation method. Methods: We retrospectively reviewed a clinical database of patients who underwent surgery for early breast cancer at Tokyo-West Tokushukai Hospital. Among them, those who underwent preoperative core needle biopsy (CNB) were enrolled. The concordance rates of estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), and Ki-67 by local pathologists were reviewed (valuations made by local pathologists), and nonmatching cases (from August 2008 to October 2011) were reassessed both by central review and using an automated analyzer with virtual slides. The results were compared with the evaluations made by local pathologists, and we reexamined the concordance rate by using central review and the automated analyzer. Results: The concordance rate of Ki-67 evaluations made by local pathologists in the preoperative CNB and surgical specimens was 78.7% in 287 cases pathologically assessed from October 2008 to March 2013. This rate was significantly lower (p < 0.01) than that of ER (95.6%), PgR (88.5%), and HER2 (91.6%). Reassessment of the 37 cases of nonmatching Ki-67 values from 2008 to October 2011 using central review and an automated analyzer resulted in clear improvement in matching of 22 (92.1%) and 24 (93.1%) of 37 cases, respectively. Conclusion: The concordance rate of Ki-67 in preoperative CNB and surgical specimens was lower than that of other biological markers;however, they were nearly equal by reassessment using central review and an automated analyzer.展开更多
In this experiment,the sperms were obtained from(C57×CBA) F1 male mice and the eggs from NIHstrain female mice.Using the fertilization techni-que in Vitro,the slides of chromosome of mouse eggsat the first cleava...In this experiment,the sperms were obtained from(C57×CBA) F1 male mice and the eggs from NIHstrain female mice.Using the fertilization techni-que in Vitro,the slides of chromosome of mouse eggsat the first cleavage metaphase were prepared.展开更多
BACKGROUND Histopathologically stained archived tissue slides are stored in hospital archives for years to decades.They are the largest available source of biological materials and are a potentially useful resource th...BACKGROUND Histopathologically stained archived tissue slides are stored in hospital archives for years to decades.They are the largest available source of biological materials and are a potentially useful resource that can be used for retrospective epidemiological studies.DNA recovered from the slides can be used for several downstream molecular processes including polymerase chain reaction,single nucleotide polymorphism analysis,and whole genome sequencing.The DNA from these slides can be utilized to compare gene signatures of normal and diseased tissues.However,extraction of high-quality DNA from archived stained hematoxylin and eosin(H&E)slides remains challenging.AIM To standardize a new protocol for extracting DNA from archived H&E-stained tissue slides for further molecular assays.METHODS A total of 100 archived H&E-stained cancer slides were subjected to a total of five methods of DNA extraction.Methods were varied in the deparaffinization step,tissue rehydration,duration of lysis,and presence or absence of proteinase K.The extracted DNA was quantified using a NanoDrop spectrophometer and the quality was analyzed by agarose gel electrophoresis.Then each sample was subjected to polymerase chain reaction(PCR)to amplify the internal control gene GAPDH,thereby confirming the DNA intactness,which could be further utilized for other downstream applications.RESULTS Of the five different methods tested,the third method wherein xylene was used for tissue deparaffinization followed by 72 h of digestion and without proteinase K inactivation yielded the highest amount of DNA with good purity.The yield was significantly higher when compared to other methods.In addition,90%of the extracted DNA showed amplifiable GAPDH gene.CONCLUSION Here we present a step-by-step,cost-effective,and reproducible protocol for the extraction of PCR-friendly DNA from archived H&E-stained cancer tissue slides that can be used for further downstream molecular applications.展开更多
With the scale extending of mining, the landslide disaster in the earth’s surface will become more and more serious, and these landslide disasters are being threatened to the sustainable safe mining of the undergroun...With the scale extending of mining, the landslide disaster in the earth’s surface will become more and more serious, and these landslide disasters are being threatened to the sustainable safe mining of the underground mine and the open-pit mine. Based on the theory that sliding force is greater than the shear resistance (resisting force) at the potential slip surface is the necessary and sufficient condition to occur the landslide as the sliding criterion, the principle and method for sliding force remote monitoring is presented, and the functional relationship between the human mechanical quantity and the natural sliding force is derived, hereby, the natural sliding force can be calculated according to the human mechanical quantity. Based on above principle and method, a new system of landslide remote monitoring is designed and 53 systems are installed on the landslide body in the Luoshan mining area, which make up the landslide remote monitoring network. According to the results of field test around 8 months, monitoring curves between sliding force and time are obtained, which can describe and forecast the develop trend of landslide. According to above analysis, the results show that this system has some following advantages: (1) real-time monitoring; (2) remote intelligent transmission; (3) landslides early warning.展开更多
Affected by typhoons over years, Fujian Province in Southeast China has developed a large number of shallow landslides, causing a long-term concern for the local government. The study on shallow landslide is not only ...Affected by typhoons over years, Fujian Province in Southeast China has developed a large number of shallow landslides, causing a long-term concern for the local government. The study on shallow landslide is not only helpful to the local government in disaster prevention, but also the theoretical basis of regional early warning technology. To determine the whole-process characteristics and failure mechanisms of flow-slide failure of granite residual soil slopes, we conducted a detailed hazard investigation in Minqing County, Fujian Province, which was impacted by Typhoon Lupit-induced heavy rainfall in August 2021. Based on the investigation and preliminary analysis results, we conducted indoor artificial rainfall physical model tests and obtained the whole-process characteristics of flow-slide failure of granite residual soil landslides. Under the action of heavy rainfall, a granite residual soil slope experiences initial deformation at the slope toe and exhibits development characteristics of continuous traction deformation toward the middle and upper parts of the slope. The critical volumetric water content during slope failure is approximately 53%. Granite residual soil is in a state of high volumetric water content under heavy rainfall conditions, and the shear strength decreases, resulting in a decrease in stability and finally failure occurrence. The new free face generated after failure constitutes an adverse condition for continued traction deformation and failure. As the soil permeability(cm/h) is less than the rainfall intensity(mm/h), and it is difficult for rainwater to continuously infiltrate in short-term rainfall, the influence depth of heavy rainfall is limited. The load of loose deposits at the slope foot also limits the development of deep deformation and failure. With the continuous effect of heavy rainfall, the surface runoff increases gradually, and the influence mode changes from instability failure caused by rainfall infiltration to erosion and scouring of surface runoff on slope surface. Transportation of loose materials by surface runoff is an important reason for prominent siltation in disaster-prone areas.展开更多
Landslides in Tianshui Basin, Gansu Province, Northwest China, severely affect the local population and the economy;therefore,understanding their evolution and kinematics is of great interest for landslide risk assess...Landslides in Tianshui Basin, Gansu Province, Northwest China, severely affect the local population and the economy;therefore,understanding their evolution and kinematics is of great interest for landslide risk assessment and prevention. However, there is no unified classification standard for the types of loess landslides in Tianshui.In this study, we explored the landslide distribution and failure characteristics by means of field investigation,remotesensinginterpretation,geological mapping, drilling exploration and shearwave velocity tests, and established a database of Tianshui landslides. Our analysis shows that shear zones in mudstone usually develop in weak intercalated layers. Landslides occur mainly along the West Qinling faults on slopes with gradients of 10° to 25° and on southeast-and southwest-facing slopes.These landslides were classified into five types: loess landslides, loess–mudstone interface landslides, loess flow-slides, loess–mudstone plane landslides and loess–mudstone cutting landslides. We discussed the evolution and failure process of each landslide type and analyzed the formation mechanism and motion characteristics of large-scale landslides. The analysis results show that the landslides in the study area are characterized by a gentle slope, long runout and high risk. The relationship between the runout L and the vertical drop H of the large-scale landslides in the study area is L > 4 H. There are good correlations between the equivalent friction coefficient of largescale landslides and their maximum height, runout,area and volume. The sliding zone of large-scale landslides often develops in the bedrock contact zone or in a weak interlayer within mudstone. From microstructure analysis, undisturbed mudstone consists mainly of small aggregates with dispersed inter-aggregate pores, whereas sheared clay has a more homogeneous structure. Linear striations are well developed on shear surfaces, and the clay pores in those surfaces have a more uniform distribution than those in undisturbed clay.展开更多
The great Wenchuan （汶川） earthquake induced a large quantity of landslides. They are widely distributed and caused tremendous damages. The sliding mechanism and characteristics of these earthquake-induced landslide...The great Wenchuan （汶川） earthquake induced a large quantity of landslides. They are widely distributed and caused tremendous damages. The sliding mechanism and characteristics of these earthquake-induced landslides are different from those of conventional gravity landslides. Their occurrences are apparently controlled by the powerful earthquake, and they are characterized by high potential energy sliding and ejection sliding. In this article, the earthquake-induced landslides are classified, the characteristics of the sliding and destruction of these landslides are described, and the rela- tionship between the earthquake and the landslides is analyzed. The Donghekou （东河口） landslide is used as an example to characterize fast-moving long-distance earthquake-induced ejection slippage and landslide. This research suggests that many phenomena and issues related to earthquake-induced land- slide are beyond current recognition and knowledge, and new methodologies should be adopted to consider the effect of the earthquake as the paramount factor in the development of landslides. Furthermore, the study of fast-moving long-distance earthquake-induced landslides can also shed light on the formation of old and ancient landslides.展开更多
The occurrence of landslides in Heifangtai plateau is primarily caused by the rise in water levels due to irrigation. To accurately understand the distribution of groundwater and its impact on the landslide hazard, a ...The occurrence of landslides in Heifangtai plateau is primarily caused by the rise in water levels due to irrigation. To accurately understand the distribution of groundwater and its impact on the landslide hazard, a combination of Electrical Resistivity Tomography(ERT), Induced Polarization(IP) and Surface Nuclear Magnetic Resonance(SNMR) methods were used in this study. By conducting a comprehensive analysis, the characteristics of water-bearing structure in vertical and groundwater distribution in horizontal were detected;and the influence of the groundwater on plateau and landslides was also identified. The results indicate that the groundwater occurs in the loess aquifer with a three-layer structure in vertical.Horizontally, the aquifer has a unified water table over the plateau, with a low water level in the north and high one in the south. The high resistivity bedrock uplift belt in the middle of the plateau forms a watershed,with the north side of the uplift belt being a relatively stable slope area with stable water content and fewer geological disasters. In contrast, the south side of the uplift belt is a disaster-prone region with vertical fissures well developed in the loess aquifers. The southern landslides are characterized by the interphase distribution of high and low electrical resistivity. The infiltration and discharge of groundwater result in the formation of a collapse belt in the low resistivity water-bearing structure of landslide, which causes the entire block with high resistivity and stable bedrock to slide. There was a newly formed landslide in a larger range at the landslide' s trailing edge. This study provides a scientific basis for the study of landslides mechanisms and disaster prevention by identifying the distribution characteristics of groundwater and analyzing its influence from a geophysical perspective in Heifangtai.展开更多
Effects of heat softening on the initiation of slide surface(shear banding) in clayey slopes during fast deformation were discussed.Controlling equations considering heat,pore pressure and mechanical movement were pre...Effects of heat softening on the initiation of slide surface(shear banding) in clayey slopes during fast deformation were discussed.Controlling equations considering heat,pore pressure and mechanical movement were presented.By perturbation method,the instability condition of localized zone(i.e.criterion for initiation of shear banding) for thermal related soils,such as clayey slope,was obtained.It is shown that slide surface initiates once the thermal-softening effects overcome the strain-hardening effects whether it is adiabatic or not.Without strain hardening effects,strain rate hardening obviously plays a role in initiation of shear band.During initiating process,heat is trapped inside the shear band,which leads rapidly to a pore pressure increase and fast loss of strength.The localized shear strain is concentrated in a narrow zone with a width of several centimeters at most and increases fast.This zone forms the sliding surface.Temperature can increase more than 2?C,pore pressure can increase 160% in about 0.1s inside this zone.These changes cause the fast decrease in friction-coefficient by about 36% over the initial value.That is how shear band initiated and developed in clayey slopes.展开更多
Submarine landslides can cause severe damage to marine engineering structures. Their sliding velocity and runout distance are two major parameters for quantifying and analyzing the risk of submarine landslides.Current...Submarine landslides can cause severe damage to marine engineering structures. Their sliding velocity and runout distance are two major parameters for quantifying and analyzing the risk of submarine landslides.Currently, commercial calculation programs such as BING have limitations in simulating underwater soil movements. All of these processes can be consistently simulated through a smoothed particle hydrodynamics（SPH） depth integrated model. The basis of the model is a control equation that was developed to take into account the effects of soil consolidation and erosion. In this work, the frictional rheological mode has been used to perform a simulation study of submarine landslides. Time-history curves of the sliding body＇s velocity, height,and length under various conditions of water depth, slope gradient, contact friction coefficient, and erosion rate are compared; the maximum sliding distance and velocity are calculated; and patterns of variation are discussed.The findings of this study can provide a reference for disaster warnings and pipeline route selection.展开更多
Estimate of the Deterministic Neutron RBE for Radiation-induced Pseudo-Pelger Huët Cell Formation R.E.Goans1,2,C.J.Iddins1,R.E.Goans,Jr.3(1.Radiation Emergency Assistance Center/Training Site,Oak Ridge,TN;2.MJW C...Estimate of the Deterministic Neutron RBE for Radiation-induced Pseudo-Pelger Huët Cell Formation R.E.Goans1,2,C.J.Iddins1,R.E.Goans,Jr.3(1.Radiation Emergency Assistance Center/Training Site,Oak Ridge,TN;2.MJW Corporation,Amherst,NY;3.LMU Debusk School of Medicine,Harrogate,TN)Abstract:Using archival peripheral blood slides from radiation accident patients,we have recently described the pseudo-Pelger Huët anomaly(PPHA)in neutrophils as a new radiation-induced biomarker,useful for dosimetry not only immediately after a radiation incident but also potentially helpful as a tool in retrospective dosimetry.展开更多
基金supported by the Major Program of the National Natural Science Foundation of China (Grant No.42090055)the National Major Scientific Instruments and Equipment Development Projects of China (Grant No.41827808)the National Nature Science Foundation of China (Grant No.42207216).
文摘The strength of the sliding zone soil determines the stability of reservoir landslides.Fluctuations in water levels cause a change in the seepage field,which serves as both the external hydrogeological environment and the internal component of a landslide.Therefore,considering the strength changes of the sliding zone with seepage effects,they correspond with the actual hydrogeological circumstances.To investigate the shear behavior of sliding zone soil under various seepage pressures,24 samples were conducted by a self-developed apparatus to observe the shear strength and measure the permeability coefficients at different deformation stages.After seepage-shear tests,the composition of clay minerals and microscopic structure on the shear surface were analyzed through X-ray and scanning electron microscope(SEM)to understand the coupling effects of seepage on strength.The results revealed that the sliding zone soil exhibited strain-hardening without seepage pressure.However,the introduction of seepage caused a significant reduction in shear strength,resulting in strain-softening characterized by a three-stage process.Long-term seepage action softened clay particles and transported broken particles into effective seepage channels,causing continuous damage to the interior structure and reducing the permeability coefficient.Increased seepage pressure decreased the peak strength by disrupting occlusal and frictional forces between sliding zone soil particles,which carried away more clay particles,contributing to an overhead structure in the soil that raised the permeability coefficient and decreased residual strength.The internal friction angle was less sensitive to variations in seepage pressure than cohesion.
基金supported by the National Natural Science Foundation of China(Nos.42090054,42377192)the Scientific Research Project of Power China Huadong Engineering Corporation Limited(No.KY2022-KC-02-02)the Natural Science Foundation of Hubei Province,China(No.2022CFA002)。
文摘0 INTRODUCTION Submarine slope slides refer to a geological process occurring on submarine slopes or continental margin slopes,where a large amount of sediment or rock layers on the slope lose stability and slide downward along the sliding surface(Kamran et al.,2023;Tong et al.,2023;Hampton et al.,1996).
基金supported by the opening fund of State Key Laboratory of Coastal and Offshore Engineering at Dalian University of Technology(No.LP2310)the opening fund of State Key Laboratory of Geohazard Prevention and Geoenvironment Protection at Chengdu University of Technology(No.SKLGP2023K001)+2 种基金the Shandong Provincial Key Laboratory of Ocean Engineering with grant at Ocean University of China(No.kloe200301)the National Natural Science Foundation of China(Nos.42022052,42077272 and 52108337)the Science and Technology Innovation Serve Project of Wenzhou Association for Science and Technology(No.KJFW65).
文摘Deep-sea pipelines play a pivotal role in seabed mineral resource development,global energy and resource supply provision,network communication,and environmental protection.However,the placement of these pipelines on the seabed surface exposes them to potential risks arising from the complex deep-sea hydrodynamic and geological environment,particularly submarine slides.Historical incidents have highlighted the substantial damage to pipelines due to slides.Specifically,deep-sea fluidized slides(in a debris/mud flow or turbidity current physical state),characterized by high speed,pose a significant threat.Accurately assessing the impact forces exerted on pipelines by fluidized submarine slides is crucial for ensuring pipeline safety.This study aimed to provide a comprehensive overview of recent advancements in understanding pipeline impact forces caused by fluidized deep-sea slides,thereby identifying key factors and corresponding mechanisms that influence pipeline impact forces.These factors include the velocity,density,and shear behavior of deep-sea fluidized slides,as well as the geometry,stiffness,self-weight,and mechanical model of pipelines.Additionally,the interface contact conditions and spatial relations were examined within the context of deep-sea slides and their interactions with pipelines.Building upon a thorough review of these achievements,future directions were proposed for assessing and characterizing the key factors affecting slide impact loading on pipelines.A comprehensive understanding of these results is essential for the sustainable development of deep-sea pipeline projects associated with seabed resource development and the implementation of disaster prevention measures.
基金support provided by the UK Engineering and Physical Sciences Research Council(EP/V012169/1).
文摘Landslides occurring in sensitive clay often result in widespread destruction,posing a significant risk to human lives and property due to the substantial decrease in undrained shear strength during deformation.Assessing the consequences of these landslides is challenging and necessitates robust numerical methods to comprehensively investigate their failure mechanisms.While studies have extensively explored upward progressive landslides in sensitive clays,understanding downward progressive cases remains limited.In this study,we utilised the nodal integration-based particle finite element method(NPFEM)with a nonlinear strain-softening model to analyse downward progressive landslides in sensitive clay on elongated slopes,induced by surcharge loads near the crest.We focused on elucidating the underlying failure mechanisms and evaluating the effects of different soil parameters and strainsoftening characteristics.The simulation results revealed the typical pattern for downward landslides,which typically start with a localised failure in proximity to the surcharge loads,followed by a combination of different types of failure mechanisms,including single flow slides,translational progressive landslides,progressive flow slides,and spread failures.Additionally,inclined shear bands occur within spread failures,often adopting distinctive ploughing patterns characterised by triangular shapes.The sensitive clay thickness at the base,the clay strength gradient,the sensitivity,and the softening rate significantly influence the failure mechanisms and the extent of diffused displacement.Remarkably,some of these effects mirror those observed in upward progressive landslides,underscoring the interconnectedness of these phenomena.This study contributes valuable insights into the complex dynamics of sensitive clay landslides,shedding light on the intricate interplay of factors governing their behaviour and progression.
文摘Background The S4SLIDE project(IGCP-640)builds upon the extremely successful E-MARSHAL and IGCP-511 projects also known as the Submarine Mass Movements and Their Consequences project.S4SLIDE has a broader reach that seeks to incorporate learnings from lacustrine,coastal and subaerial landslides.As with its predecessors,the IGCP-640 project focuses on facilitating the interaction of scientists,engineers,industry and government representatives,and other parties interested in subaqueous mass movements and their geohazard potential.
文摘Background The S4SLIDE project(IGCP-640)builds upon the extremely successful E-MARSHAL and IGCP-511 projects also known as the Submarine Mass Movements and Their Consequences project.S4SLIDE has a broader reach that seeks to incorporate learnings from lacustrine,coastal and subaerial landslides.As with its predecessors,the IGCP-640 project focuses on facilitating the interaction of scientists,engineers,industry and government representatives,and other parties interested in subaqueous mass movements and their geohazard potential.
基金This work was financially supported by the Program of National Natural Science Foundation of China(41807234,42090053,41790441,42107198,42041006,41902300,41672255,300102269203,300102261401)supported by the CRSRI Open Research Program(Program SN:CKWV2021873/KY).
文摘Loess landslides are one of the most serious geological disasters in the Chinese Loess Plateau.Research has revealed that earthquake,rainfall,and human activities are common triggers for loess landslides.In order to study the relationship and characteristics of these landslides triggered by different factors,the paper uses historic landslide data to expound the basic motion indices of landslides triggered by different factors.More than half of loess landslides occurred on concave surface slopes,while nearly 40%of the loess landslides occurred on convex surface slopes.Human activities have a great effect on the occurrence of landslides,and the distribution density of landslides on residential land was almost five times that of bare land.Additionally,earthquakeinduced loess landslides had the largest sliding volume,whereas the excavation-induced loess landslide had the smallest sliding volume.The sliding volume of irrigation-induced and rainfall-induced loess landslides were between earthquake-induced loess landslides and excavation-induced loess landslide.Many of loess landslides were induced by a combination of these factors,such as rainfall and excavation,irrigation and excavation.Then a model that described the impact of these factors on the loess landslides was proposed.
基金Project supported by the National Natural Science Foundation of China(Nos.51325903 and 51279218)Natural Science Foundation Project of CQ CSTC(Nos.CSTC2013KJRC-1JCCJ30001 and CSTC2015jcyjys30001)the Fundamental Research Funds for the Central Universities(No.CDJXS12201108)
文摘In the past, the pseudo-static method used to be the most common for evaluating the stability of landslides under seismic loads, in which static forces acting on the center of gravity of a sliding body are used to consider the effects of earthquake. However, seismic loads of rock and soil differ from time and location to time and location. Obviously, it is irrational for the pseudo-static approach to be applied to solving dynamic problems. In this paper, a displacement- pseudo-dynamic model is proposed to assess seismic stability of landslides, in which the sinusoidal- cosinusoidal wave is applied to simulating earthquake displacement, and an ＂amplification factor＂ of peak seismic displacement is referred to as the amplification of seismic wave when it propagates from the bottom to the top of the landslide. The effects of physico-mechanical behaviors of a sliding body on seismic stability of soil slopes are taken into account as well as inertia forces and damping forces. The sensitivity analyses on the permanent displacement and the dynamic factor of safety of landslides are studied in detail. Moreover, a large-scale Tangjiashan landslide that occurred in Wenchuan earthquake is investigated to verify the robustness and precision of the present method. It is found that the results from the present method is in good agreement with those from the previous method.
文摘Purpose: To standardize the methods to measure Ki-67, there is an interest in automating the assessment of Ki-67. Therefore, we reviewed the possibility of introducing an automated analyzer to standardize the Ki-67 evaluation method. Methods: We retrospectively reviewed a clinical database of patients who underwent surgery for early breast cancer at Tokyo-West Tokushukai Hospital. Among them, those who underwent preoperative core needle biopsy (CNB) were enrolled. The concordance rates of estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), and Ki-67 by local pathologists were reviewed (valuations made by local pathologists), and nonmatching cases (from August 2008 to October 2011) were reassessed both by central review and using an automated analyzer with virtual slides. The results were compared with the evaluations made by local pathologists, and we reexamined the concordance rate by using central review and the automated analyzer. Results: The concordance rate of Ki-67 evaluations made by local pathologists in the preoperative CNB and surgical specimens was 78.7% in 287 cases pathologically assessed from October 2008 to March 2013. This rate was significantly lower (p < 0.01) than that of ER (95.6%), PgR (88.5%), and HER2 (91.6%). Reassessment of the 37 cases of nonmatching Ki-67 values from 2008 to October 2011 using central review and an automated analyzer resulted in clear improvement in matching of 22 (92.1%) and 24 (93.1%) of 37 cases, respectively. Conclusion: The concordance rate of Ki-67 in preoperative CNB and surgical specimens was lower than that of other biological markers;however, they were nearly equal by reassessment using central review and an automated analyzer.
文摘In this experiment,the sperms were obtained from(C57×CBA) F1 male mice and the eggs from NIHstrain female mice.Using the fertilization techni-que in Vitro,the slides of chromosome of mouse eggsat the first cleavage metaphase were prepared.
基金the junior research fellowship from the Council of Scientific and Industrial Research, Government of India
文摘BACKGROUND Histopathologically stained archived tissue slides are stored in hospital archives for years to decades.They are the largest available source of biological materials and are a potentially useful resource that can be used for retrospective epidemiological studies.DNA recovered from the slides can be used for several downstream molecular processes including polymerase chain reaction,single nucleotide polymorphism analysis,and whole genome sequencing.The DNA from these slides can be utilized to compare gene signatures of normal and diseased tissues.However,extraction of high-quality DNA from archived stained hematoxylin and eosin(H&E)slides remains challenging.AIM To standardize a new protocol for extracting DNA from archived H&E-stained tissue slides for further molecular assays.METHODS A total of 100 archived H&E-stained cancer slides were subjected to a total of five methods of DNA extraction.Methods were varied in the deparaffinization step,tissue rehydration,duration of lysis,and presence or absence of proteinase K.The extracted DNA was quantified using a NanoDrop spectrophometer and the quality was analyzed by agarose gel electrophoresis.Then each sample was subjected to polymerase chain reaction(PCR)to amplify the internal control gene GAPDH,thereby confirming the DNA intactness,which could be further utilized for other downstream applications.RESULTS Of the five different methods tested,the third method wherein xylene was used for tissue deparaffinization followed by 72 h of digestion and without proteinase K inactivation yielded the highest amount of DNA with good purity.The yield was significantly higher when compared to other methods.In addition,90%of the extracted DNA showed amplifiable GAPDH gene.CONCLUSION Here we present a step-by-step,cost-effective,and reproducible protocol for the extraction of PCR-friendly DNA from archived H&E-stained cancer tissue slides that can be used for further downstream molecular applications.
基金Project 2006CB202200 supported by the National Basic Research Program of China
文摘With the scale extending of mining, the landslide disaster in the earth’s surface will become more and more serious, and these landslide disasters are being threatened to the sustainable safe mining of the underground mine and the open-pit mine. Based on the theory that sliding force is greater than the shear resistance (resisting force) at the potential slip surface is the necessary and sufficient condition to occur the landslide as the sliding criterion, the principle and method for sliding force remote monitoring is presented, and the functional relationship between the human mechanical quantity and the natural sliding force is derived, hereby, the natural sliding force can be calculated according to the human mechanical quantity. Based on above principle and method, a new system of landslide remote monitoring is designed and 53 systems are installed on the landslide body in the Luoshan mining area, which make up the landslide remote monitoring network. According to the results of field test around 8 months, monitoring curves between sliding force and time are obtained, which can describe and forecast the develop trend of landslide. According to above analysis, the results show that this system has some following advantages: (1) real-time monitoring; (2) remote intelligent transmission; (3) landslides early warning.
基金funded by the National Natural Science Foundation of China(Grant Nos.U2005205,41977252)National Key R&D Program of China(2018YFC1505503)+1 种基金Open Fund of Key Laboratory of Geohazard Prevention of Hilly Mountains,Ministry of Natural Resources(Fujian Key Laboratory of Geohazard Prevention)(FJKLGH2022K001)the State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Independent Research Project(Grant No.SKLGP2020Z001)。
文摘Affected by typhoons over years, Fujian Province in Southeast China has developed a large number of shallow landslides, causing a long-term concern for the local government. The study on shallow landslide is not only helpful to the local government in disaster prevention, but also the theoretical basis of regional early warning technology. To determine the whole-process characteristics and failure mechanisms of flow-slide failure of granite residual soil slopes, we conducted a detailed hazard investigation in Minqing County, Fujian Province, which was impacted by Typhoon Lupit-induced heavy rainfall in August 2021. Based on the investigation and preliminary analysis results, we conducted indoor artificial rainfall physical model tests and obtained the whole-process characteristics of flow-slide failure of granite residual soil landslides. Under the action of heavy rainfall, a granite residual soil slope experiences initial deformation at the slope toe and exhibits development characteristics of continuous traction deformation toward the middle and upper parts of the slope. The critical volumetric water content during slope failure is approximately 53%. Granite residual soil is in a state of high volumetric water content under heavy rainfall conditions, and the shear strength decreases, resulting in a decrease in stability and finally failure occurrence. The new free face generated after failure constitutes an adverse condition for continued traction deformation and failure. As the soil permeability(cm/h) is less than the rainfall intensity(mm/h), and it is difficult for rainwater to continuously infiltrate in short-term rainfall, the influence depth of heavy rainfall is limited. The load of loose deposits at the slope foot also limits the development of deep deformation and failure. With the continuous effect of heavy rainfall, the surface runoff increases gradually, and the influence mode changes from instability failure caused by rainfall infiltration to erosion and scouring of surface runoff on slope surface. Transportation of loose materials by surface runoff is an important reason for prominent siltation in disaster-prone areas.
基金This study was sponsored by National Natural Science Foundation of China(Grant No.41902269 and No.41702343)Project of China geological survey(Grant No.DD20190717)The authors express their sincere thanks to the reviewers and editor for their help.
文摘Landslides in Tianshui Basin, Gansu Province, Northwest China, severely affect the local population and the economy;therefore,understanding their evolution and kinematics is of great interest for landslide risk assessment and prevention. However, there is no unified classification standard for the types of loess landslides in Tianshui.In this study, we explored the landslide distribution and failure characteristics by means of field investigation,remotesensinginterpretation,geological mapping, drilling exploration and shearwave velocity tests, and established a database of Tianshui landslides. Our analysis shows that shear zones in mudstone usually develop in weak intercalated layers. Landslides occur mainly along the West Qinling faults on slopes with gradients of 10° to 25° and on southeast-and southwest-facing slopes.These landslides were classified into five types: loess landslides, loess–mudstone interface landslides, loess flow-slides, loess–mudstone plane landslides and loess–mudstone cutting landslides. We discussed the evolution and failure process of each landslide type and analyzed the formation mechanism and motion characteristics of large-scale landslides. The analysis results show that the landslides in the study area are characterized by a gentle slope, long runout and high risk. The relationship between the runout L and the vertical drop H of the large-scale landslides in the study area is L > 4 H. There are good correlations between the equivalent friction coefficient of largescale landslides and their maximum height, runout,area and volume. The sliding zone of large-scale landslides often develops in the bedrock contact zone or in a weak interlayer within mudstone. From microstructure analysis, undisturbed mudstone consists mainly of small aggregates with dispersed inter-aggregate pores, whereas sheared clay has a more homogeneous structure. Linear striations are well developed on shear surfaces, and the clay pores in those surfaces have a more uniform distribution than those in undisturbed clay.
文摘The great Wenchuan （汶川） earthquake induced a large quantity of landslides. They are widely distributed and caused tremendous damages. The sliding mechanism and characteristics of these earthquake-induced landslides are different from those of conventional gravity landslides. Their occurrences are apparently controlled by the powerful earthquake, and they are characterized by high potential energy sliding and ejection sliding. In this article, the earthquake-induced landslides are classified, the characteristics of the sliding and destruction of these landslides are described, and the rela- tionship between the earthquake and the landslides is analyzed. The Donghekou （东河口） landslide is used as an example to characterize fast-moving long-distance earthquake-induced ejection slippage and landslide. This research suggests that many phenomena and issues related to earthquake-induced land- slide are beyond current recognition and knowledge, and new methodologies should be adopted to consider the effect of the earthquake as the paramount factor in the development of landslides. Furthermore, the study of fast-moving long-distance earthquake-induced landslides can also shed light on the formation of old and ancient landslides.
基金supported and funded by the National Natural Science Foundation of China (Grant No: 42177346, 52009103)the Key Laboratory for Groundwater and Ecology in Arid and Semi-arid Areasthe China Geological Survey project (No: DD20190296)。
文摘The occurrence of landslides in Heifangtai plateau is primarily caused by the rise in water levels due to irrigation. To accurately understand the distribution of groundwater and its impact on the landslide hazard, a combination of Electrical Resistivity Tomography(ERT), Induced Polarization(IP) and Surface Nuclear Magnetic Resonance(SNMR) methods were used in this study. By conducting a comprehensive analysis, the characteristics of water-bearing structure in vertical and groundwater distribution in horizontal were detected;and the influence of the groundwater on plateau and landslides was also identified. The results indicate that the groundwater occurs in the loess aquifer with a three-layer structure in vertical.Horizontally, the aquifer has a unified water table over the plateau, with a low water level in the north and high one in the south. The high resistivity bedrock uplift belt in the middle of the plateau forms a watershed,with the north side of the uplift belt being a relatively stable slope area with stable water content and fewer geological disasters. In contrast, the south side of the uplift belt is a disaster-prone region with vertical fissures well developed in the loess aquifers. The southern landslides are characterized by the interphase distribution of high and low electrical resistivity. The infiltration and discharge of groundwater result in the formation of a collapse belt in the low resistivity water-bearing structure of landslide, which causes the entire block with high resistivity and stable bedrock to slide. There was a newly formed landslide in a larger range at the landslide' s trailing edge. This study provides a scientific basis for the study of landslides mechanisms and disaster prevention by identifying the distribution characteristics of groundwater and analyzing its influence from a geophysical perspective in Heifangtai.
基金funded by the National Natural Science Foundation of China (Grant No. 11272314 No. 51239010)+1 种基金the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20133514110004)the Research Project of Chinese Ministry of Transport (Grant No. 201331849A130)
文摘Effects of heat softening on the initiation of slide surface(shear banding) in clayey slopes during fast deformation were discussed.Controlling equations considering heat,pore pressure and mechanical movement were presented.By perturbation method,the instability condition of localized zone(i.e.criterion for initiation of shear banding) for thermal related soils,such as clayey slope,was obtained.It is shown that slide surface initiates once the thermal-softening effects overcome the strain-hardening effects whether it is adiabatic or not.Without strain hardening effects,strain rate hardening obviously plays a role in initiation of shear band.During initiating process,heat is trapped inside the shear band,which leads rapidly to a pore pressure increase and fast loss of strength.The localized shear strain is concentrated in a narrow zone with a width of several centimeters at most and increases fast.This zone forms the sliding surface.Temperature can increase more than 2?C,pore pressure can increase 160% in about 0.1s inside this zone.These changes cause the fast decrease in friction-coefficient by about 36% over the initial value.That is how shear band initiated and developed in clayey slopes.
基金The Specialized Research Fund for the Doctoral Program of Higher Education under contract No.20120041130002the National Key Project of Science and Technology under contract No.2011ZX 05056-001-02the Fundamental Research Funds for the Central Universities under contract No.DUT14ZD220
文摘Submarine landslides can cause severe damage to marine engineering structures. Their sliding velocity and runout distance are two major parameters for quantifying and analyzing the risk of submarine landslides.Currently, commercial calculation programs such as BING have limitations in simulating underwater soil movements. All of these processes can be consistently simulated through a smoothed particle hydrodynamics（SPH） depth integrated model. The basis of the model is a control equation that was developed to take into account the effects of soil consolidation and erosion. In this work, the frictional rheological mode has been used to perform a simulation study of submarine landslides. Time-history curves of the sliding body＇s velocity, height,and length under various conditions of water depth, slope gradient, contact friction coefficient, and erosion rate are compared; the maximum sliding distance and velocity are calculated; and patterns of variation are discussed.The findings of this study can provide a reference for disaster warnings and pipeline route selection.
文摘Estimate of the Deterministic Neutron RBE for Radiation-induced Pseudo-Pelger Huët Cell Formation R.E.Goans1,2,C.J.Iddins1,R.E.Goans,Jr.3(1.Radiation Emergency Assistance Center/Training Site,Oak Ridge,TN;2.MJW Corporation,Amherst,NY;3.LMU Debusk School of Medicine,Harrogate,TN)Abstract:Using archival peripheral blood slides from radiation accident patients,we have recently described the pseudo-Pelger Huët anomaly(PPHA)in neutrophils as a new radiation-induced biomarker,useful for dosimetry not only immediately after a radiation incident but also potentially helpful as a tool in retrospective dosimetry.
