Background:Human skin is affected by ultraviolet rays on a daily basis,and excessive ultraviolet radiation(UVR)can lead to sunburn erythema,tanning,photoaging,and skin tumors.The combination of Astragali Radix(AR)and ...Background:Human skin is affected by ultraviolet rays on a daily basis,and excessive ultraviolet radiation(UVR)can lead to sunburn erythema,tanning,photoaging,and skin tumors.The combination of Astragali Radix(AR)and Anemarrhenae Rhizoma(AAR)is a common pairing in traditional Chinese medicine(TCM).According to earlier studies,they possess properties capable of alleviating the adverse impacts of UVR on the skin.However,the specific actions and underlying mechanisms require further investigation.The study aims to analyze the efficacy of AR-AAR in preventing UVR-induced skin damage and to clarify the associated molecular mechanisms.Methods:Potential signaling pathways by which AR and AAR may protect against UVR-induced skin damage were identified with network pharmacology,molecular docking techniques and molecular dynamics(MD)simulation.Except the normal group,the back skin of SD rats was exposed to 1.1 mW/cm^(2) UVA combined with 0.1 mW/cm^(2) UVB daily,and the UVR skin damage model was established.Morphological features of skin tissues of different groups were discovered through Hematoxylin and Eosin(HE)staining,Masson staining,Weigert staining.ELISA was utilized to measure the levels of reactive oxygen species(ROS),Interleukin 6(IL-6),Interleukin 1β(IL-1β)and Tumor necrosis factos-α(TNF-α)in skin tissues.RT-PCR and Western blot were employed to quantify the mRNA and protein contents of PI3K,AKT,and MMP-9.Results:Network pharmacology analysis predicts that AR-AAR may improve skin damage induced by UVR through the PI3K/AKT signaling pathway.Histological staining shows that AR-AAR can significantly reduce inflammatory infiltration and fibrosis in damaged skin.Treatment with AR-AAR(2:1)significantly reduced the expression levels of IL-1β,IL-6,TNF-αand ROS in UVR-damaged rat skin.After treatment with AR-AAR(2:1),not only did the relative mRNA expression levels of PI3K and AKT and the protein expression levels of PI3K,AKT,P-PI3K,and P-AKT increase,but the mRNA and protein expression levels of MMP-9 decreased.Conclusion:The study indicate that the AR-AAR combination and its active components may mitigate UVR skin damage by modulating the PI3K/AKT signaling pathway.展开更多
Oats, frequently incorporated into skincare formulations for their anti-inflammatory, moisturizing, and barrier-repairing properties, may present an overlooked risk to individuals with celiac disease, particularly whe...Oats, frequently incorporated into skincare formulations for their anti-inflammatory, moisturizing, and barrier-repairing properties, may present an overlooked risk to individuals with celiac disease, particularly when applied to compromised skin. Although pure oats are inherently gluten-free, the widespread contamination with gluten-containing grains like wheat, barley, or rye during agricultural and processing stages introduces the potential for gluten exposure through topical application. This raises important questions about whether gluten proteins, when applied to damaged skin, might penetrate the epidermal barrier and contribute to immune responses in genetically predisposed celiac patients, given that even minute amounts of gluten can trigger systemic symptoms. Emerging evidence suggests that transdermal absorption of gluten peptides through impaired skin integrity might bypass the gastrointestinal route, yet the precise mechanisms and clinical significance of this pathway remain poorly understood. The role of compromised skin in facilitating gluten absorption and the possible activation of CD4+ T-cells, mimicking gastrointestinal pathways, warrants further investigation. Additionally, the ability of gluten peptides to reach deeper dermal layers and potentially enter the systemic circulation remains speculative, though theoretically possible in severely disrupted skin barriers. Without clinical and molecular studies to determine the risk of topical gluten exposure, particularly in celiac patients with skin injuries, there remains a potential for undetected immune activation and subsequent adverse health outcomes in this sensitive population.展开更多
By recruiting 30 participants with striae gravidarum and using anti-wrinkle skincare products as an intervention measure,skin elasticity testing,skin firmness testing,and stretch mark image collection were conducted b...By recruiting 30 participants with striae gravidarum and using anti-wrinkle skincare products as an intervention measure,skin elasticity testing,skin firmness testing,and stretch mark image collection were conducted before use the anti-wrinkle skincare products,on the 14th,28th,and 56th day of use the antiwrinkle skincare products,respectively.Combined with visual evaluation by researchers and self-assessment by participants,the role of anti-wrinkle skincare products in improving stretch marks during pregnancy was explored.The results showed that on the 14th,28th,and 56th day of using efficacy skincare products,the average depth,area,and volume of stretch marks in the test area decreased compared to the baseline values before use and showed statistical differences(P<0.05);The measured values of R5 and R7 parameters for evaluating skin elasticity at the test site were significantly higher than the baseline values before use(P<0.05).On the 28th and 56th day of using efficacy skincare products,the measured values of the skin firmness evaluation parameters in the test area decreased significantly compared to the baseline values before use,and there was a statistical difference(P<0.05).The scores of the number,depth,and skin laxity of abdominal stretch marks in the visual assessment of the researchers and self-assessment of the subjects were significantly reduced on days 14,28,and 56 compared to before using the anti-wrinkle skincare product(P<0.05).This suggests that the anti-wrinkle skincare product has the effect of improving the elasticity and firmness of the skin in subjects with striae gravidarum,as well as improving striae gravidarum.展开更多
This comprehensive review explores the multifaceted landscape of skin bioprinting,revolutionizing dermatological research.The applications of skin bioprinting utilizing techniques like extrusion-,droplet-,laser-and li...This comprehensive review explores the multifaceted landscape of skin bioprinting,revolutionizing dermatological research.The applications of skin bioprinting utilizing techniques like extrusion-,droplet-,laser-and light-based methods,with specialized bioinks for skin biofabrication have been critically reviewed along with the intricate aspects of bioprinting hair follicles,sweat glands,and achieving skin pigmentation.Challenges remain with the need for vascularization,safety concerns,and the integration of automated processes for effective clinical translation.The review further investigates the incorporation of biosensor technologies,emphasizing their role in monitoring and enhancing the wound healing process.While highlighting the remarkable progress in the field,critical limitations and concerns are critically examined to provide a balanced perspective.This synthesis aims to guide scientists,engineers,and healthcare providers,fostering a deeper understanding of the current state,challenges,and future directions in skin bioprinting for transformative applications in tissue engineering and regenerative medicine.展开更多
<strong>Background:</strong> Previous studies have not specifically measured skin characteristics at common sites of pressure ulcers in high-risk elderly patients. Therefore, this study aimed to clarify th...<strong>Background:</strong> Previous studies have not specifically measured skin characteristics at common sites of pressure ulcers in high-risk elderly patients. Therefore, this study aimed to clarify the physiological skin characteristics at common pressure ulcer sites and their relationship with pressure ulcer risk and demographic/laboratory data in bedridden elderly Japanese patients. <strong>Methods:</strong> This study involved 55 elderly Japanese patients in a long-term care hospital and 25 female Japanese university students. Skin surface temperature, epidermal water content, transepidermal water loss, skin erythema/redness, skin elasticity, and skin thickness were measured using noninvasive devices. The sacral and both heel areas (sites predisposed to pressure ulcers) and mid-to-lower back area (control site) were observed. <strong>Results:</strong> Elderly patients showed a low epidermal water content at both heels (right heel, 14.8 ± 9.1 arbitrary units, AU.;left heel, 14.4 ± 8.3 AU). Transepidermal water loss remained acceptable at all sites in older patients despite the presence of dry skin (back, 7.1 ± 1.8 g/hm<sup>2</sup>;sacrum, 7.4 ± 3.0 g/hm<sup>2</sup>;right heel, 17.7 ± 7.1 g/hm<sup>2</sup>;left heel, 19.4 ± 8.1 g/hm<sup>2</sup>). Back (0.61 ± 0.13 AU) and sacral (0.67 ± 0.11 AU) skin elasticity and sacral skin thickness (0.97 ± 0.56 cm) were significantly lower than those of healthy young people (0.86 ± 0.04 AU, 0.87 ± 0.05 AU, and 2.27 ± 0.84 cm, respectively;<em>p</em> < 0.001 for all sites). Moderate positive correlations were observed between back skin elasticity and serum albumin level (r = 0.445, <em>p</em> < 0.001), and between sacral skin thickness and BMI (r = 0.506, <em>p</em> < 0.001) in older patients. <strong>Conclusions:</strong> Our findings showed that skin thickness and elasticity should be prioritized when evaluating pressure ulcer risk at the sacral region in bedridden elderly Japanese patients. Moreover, skin moisturization should be considered to minimize the risk at the heels in such patients.展开更多
Currently,research on N^(6)-methyladenine(m^(6)A)is extensive in the field of oncology,while studies involving m^(6)A and skin diseases remain relatively limited.Based on existing reports,we searched PubMed and Web of...Currently,research on N^(6)-methyladenine(m^(6)A)is extensive in the field of oncology,while studies involving m^(6)A and skin diseases remain relatively limited.Based on existing reports,we searched PubMed and Web of Science for literature related to m^(6)A and dermatological conditions.Analysis of citation counts and journal impact factors revealed a significant upward trend in the volume of m^(6)A-related research.Term frequency analysis of titles and abstracts indicated that studies mainly focus on skin tumors and inflammatory or immune-related skin diseases,particularly melanoma,psoriasis,and skin development.Transcriptomic data from the Gene Expression Omnibus(GEO)were analyzed,revealing differential expression of m^(6)A-related genes in 4 types of skin tumors(including squamous cell carcinoma and basal cell carcinoma)as well as in inflammatory skin diseases such as psoriasis and atopic dermatitis,and potential mechanisms of action were also explored.Findings suggest that m^(6)A modifications exhibit heterogeneity between neoplastic and nonneoplastic skin diseases.However,the regulatory mechanisms of m^(6)A dynamic modifications on key genes involved in dermatological disorders remain unclear and warrant further investigation.展开更多
The pervasive use of photo editing applications such as Photoshop and FaceTune has significantly altered societal beauty standards, particularly for individuals with skin of color, often leading to unrealistic expecta...The pervasive use of photo editing applications such as Photoshop and FaceTune has significantly altered societal beauty standards, particularly for individuals with skin of color, often leading to unrealistic expectations regarding skin appearance and health. These tools allow users to smooth skin textures, lighten skin tones, and erase imperfections, perpetuating Eurocentric beauty ideals that frequently marginalize the natural diversity of skin tones and textures. Consequently, individuals with skin of color may seek dermatological interventions—such as skin lightening treatments, aggressive acne scar revisions, and other cosmetic procedures—aimed at achieving appearances that align more closely with digitally manipulated images. This pursuit of an unattainable aesthetic can result in increased dissatisfaction with common skin conditions like hyperpigmentation and keloids, which are often misrepresented in edited photos. Additionally, the psychological impact of these alterations can exacerbate feelings of inadequacy, contributing to conditions such as anxiety and body dysmorphic disorder. Dermatologists face the dual challenge of addressing patients’ clinical needs while also managing their expectations shaped by digital enhancements. To combat this, it is essential for dermatologists to integrate patient education that emphasizes the beauty of diverse skin tones and the discrepancies between digital images and authentic skin health. By fostering an understanding of realistic outcomes and promoting the acceptance of natural skin characteristics, dermatologists can empower individuals with skin of color to prioritize authentic skin health over digitally influenced ideals, ultimately leading to more satisfying dermatological care and improved self-image.展开更多
Skin cancer is the most prevalent cancer globally,primarily due to extensive exposure to Ultraviolet(UV)radiation.Early identification of skin cancer enhances the likelihood of effective treatment,as delays may lead t...Skin cancer is the most prevalent cancer globally,primarily due to extensive exposure to Ultraviolet(UV)radiation.Early identification of skin cancer enhances the likelihood of effective treatment,as delays may lead to severe tumor advancement.This study proposes a novel hybrid deep learning strategy to address the complex issue of skin cancer diagnosis,with an architecture that integrates a Vision Transformer,a bespoke convolutional neural network(CNN),and an Xception module.They were evaluated using two benchmark datasets,HAM10000 and Skin Cancer ISIC.On the HAM10000,the model achieves a precision of 95.46%,an accuracy of 96.74%,a recall of 96.27%,specificity of 96.00%and an F1-Score of 95.86%.It obtains an accuracy of 93.19%,a precision of 93.25%,a recall of 92.80%,a specificity of 92.89%and an F1-Score of 93.19%on the Skin Cancer ISIC dataset.The findings demonstrate that the model that was proposed is robust and trustworthy when it comes to the classification of skin lesions.In addition,the utilization of Explainable AI techniques,such as Grad-CAM visualizations,assists in highlighting the most significant lesion areas that have an impact on the decisions that are made by the model.展开更多
Skin cutaneous melanoma(SKCM),a highly invasive malignant tumor originating from skin melanocytes,poses a significant threat to public health[1,2].Its development is closely associated with multiple factors,such as ul...Skin cutaneous melanoma(SKCM),a highly invasive malignant tumor originating from skin melanocytes,poses a significant threat to public health[1,2].Its development is closely associated with multiple factors,such as ultraviolet radiation,gene mutations,and immune escape.Among these,imbalance in the immune surveillance and clearance of tumor cells is a crucial link to disease progression[3,4].Tripartite motif-containing 27,which belongs to the TRIM protein family and is encoded by the TRIM27 gene,contains the RING,B-box,and coiled-coil domains.It participates in biological processes such as cell-cycle regulation,signal transduction,and immune response mainly by modifying target proteins through ubiquitination.Notably,increasing evidence indicates that TRIM27 is closely associated with the tumor immune microenvironment and contributes to cancer immune escape via multiple mechanisms,thereby promoting tumor development[5].However,the role of TRIM27 in SKCM remains unclear,thus prompting our investigation to elucidate this.展开更多
Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface chemistry.This feature makes them appropriate for use as functional and bio...Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface chemistry.This feature makes them appropriate for use as functional and biocompatible nano-formulations.By optimizing the absorption of longitudinally localized surface plasmon resonance in the near-infrared region,which corresponds to the near-infrared bio-tissue window,GNRs with appropriate modifications may improve the results of photothermal treatment(PTT).In dermatology,potential noninvasive uses of GNRs to enhance wound healing,manage infections,combat cutaneous malignancies,and remodel skin tissues via PTT have attracted research attention in recent years.The review discussed the basic properties of GNRs,such as their shape,size,optical performance,photothermal efficiency,and metabolism.Then,the disadvantages of using these particles in photodynamic therapy are highlighted.Next,biological applications of GNRs-based PTT are explored in detail.Finally,the limitations and future perspectives of this research are addressed,providing a comprehensive perspective on the potential GNRs with PTT.展开更多
Mitochondria are not only the main source of cellular energy but also participate in regulating key physiological processes such as intracellular oxidative stress,signal transduction,and apoptosis,which are crucial fo...Mitochondria are not only the main source of cellular energy but also participate in regulating key physiological processes such as intracellular oxidative stress,signal transduction,and apoptosis,which are crucial for maintaining the structure and function of the skin.Increasing evidence suggests that abnormalities in mitochondrial structure,function,and regulation are closely related to the occurrence and development of skin photoaging.However,the critical role of mitochondria in skin photoaging has yet to be thoroughly explored and studied.In this review,we summarize the roles of mitochondria in the occurrence and development of skin photoaging,aiming to provide new ideas and methods for the prevention and treatment of skin photoaging.展开更多
BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients oft...BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients often experience bad moods,sleep disorders,and other health issues.Despite recognizing these factors,no studies have examined the correlation between inflammatory factors,lactic acid levels,ASF,mood disturbances,and sleep quality in critically ill patients.We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality,which may inform clinical treatment for septic shock and ASF.AIM To explore the relationship between inflammatory factors,lactic acid levels,the severity of ASF,bad mood,and sleep quality.METHODS The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University,categorized into ASF(n=35)or non-ASF groups(n=115).We compared the peripheral blood inflammatory factors,including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),lactic acid levels,skin mottling score(SMS),modified early warning score(MEWS),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and Pittsburgh sleep quality index(PSQI)scores.Pearson correlation analysis assessed relationships among these variables.RESULTS The ASF group had significantly higher levels of CRP(19.60±4.10 vs 15.30±2.96 mg/mL),IL-6(298.65±48.65 vs 268.66±33.66 pg/L),procalcitonin,lactic acid(8.42±2.32 vs 5.70±1.27 mmol/L),SMS[0(0,1)vs 3(2,3)],MEWS(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),and PSQI scores(14.23±3.94 vs 8.69±2.46)compared with the non-ASF group(all P<0.001).Pearson correlation analysis revealed that IL-6,CRP,TNF-α,and lactic acid were positively correlated with SMS,MEWS,SAS,SDS,and PSQI scores(P<0.05).CONCLUSION Peripheral blood levels of IL-6,CRP,TNF-α,and lactic acid correlate positively with SMS,MEWS,SAS,SDS,and PSQI in critically ill patients with ASF.展开更多
Plum blossom pile is a new type of special-shaped pile, which is proposed based on the principle of maximum perimeter with the same cross-sectional area. To advance this technique, primarily for the design of plum blo...Plum blossom pile is a new type of special-shaped pile, which is proposed based on the principle of maximum perimeter with the same cross-sectional area. To advance this technique, primarily for the design of plum blossom piles, it is important to investigate the skin friction behavior of plum blossom pile foundations precluding any straightforward constitutive model. In this work, an analytic method dependent on the cross-sectional geometry and the vertical shearing effects is proposed by means of equilibrium analysis to calculate the effective vertical stress in the surrounding soil, the skin friction/negative skin friction, and the axial force/dragload of a plum blossom pile. Additionally, the curves of skin friction of piles are investigated with the same conditions. The results show that the curves of skin friction of piles deduced according to the developed analytic method agree well with the FEM results and related literature solution, which validates the solution. The axial force of the pile decreases with the increase of the shear action coefficient in the buried depth direction under the vertical concentrated load when considering the vertical shearing effects on the pile-soil interfaces.展开更多
Lumpy skin disease(LSD)is a highly contagious disease caused by lumpy skin disease virus(LSDV)in bovines.Rapid and accurate diagnosis is very important to controll it.However,current commercial detection kits need to ...Lumpy skin disease(LSD)is a highly contagious disease caused by lumpy skin disease virus(LSDV)in bovines.Rapid and accurate diagnosis is very important to controll it.However,current commercial detection kits need to be improved in terms of sensitivity or specificity.This study aimed to develop a novel diagnostic competitive enzyme-linked immunosorbent assay(cELISA)based on the newly identified antigen gene LSDV034.The rLSDV034 protein was identified as a potential diagnostic antigen,and it was expressed,purified,and used to immunize BALB/c mice.Using laboratory-prepared indirect ELISA(iELISA),the positive cell lines were screened,and their blocking activity was further verified by competitive ELISA(cELISA).The cell line,1H7,was chosen to produce mouse ascites,which were purified for a monoclonal antibody(mAb,5.395 mg/mL).The heavy chain type of the 1H7 mAb was identified as IgG1a,and its light chain subtype was identified as κ.Furthermore,cELISA was developed to detect bovine serum antibodies,with rLSDV034(4μg/mL)as the coating antigen and HRP-1H7 mAb(1:300)as the competitive antibody.The cutoff value of cELISA was 55%,based on 32 negative bovine serum samples.The analytical sensitivity was 1:8,and no cross-reaction was detected with bovine viral diarrhea virus(BVDV),infectious bovine rhinotracheitis virus(IBRV),Pasteurella multocida(P.multocida),or Mycoplasma bovis(M.bovis)from the serum samples.The diagnostic sensitivity and specificity of cELISA were 98.46%(95%confidence interval,CI:91.7–100)and 100%(95%CI:89.1–100),respectively,based on the analysis of 30 LSDV-infected bovine serum samples,35 GTPV-vaccinated samples,and 32 negative samples.The overall coincidence of the cELISA with the virus neutralization test(VNT)reached 98.97%(95%CI:94.4–100).Furthermore,we used cELISA to analyze 230 clinical bovine serum samples(including 59 infected and 171 vaccinated samples)and found that the serum positivity rates of the immunized samples(on d 60 postimmunization)and infected samples were 77.78%(95%CI:70.8–83.8%)and 71.19%(95%CI:57.9–82.2),respectively.These results indicate that the developed cELISA is promising for detecting serum antibodies in naturally infected or vaccinated cattle.展开更多
BACKGROUND Research has been increasingly conducted on the connection between mesenchymal stem cell(MSC)-conditioned medium(MSC-CM)and aging.However,most studies have focused on adipose-derived MSC-CM(ADMSC-CM),result...BACKGROUND Research has been increasingly conducted on the connection between mesenchymal stem cell(MSC)-conditioned medium(MSC-CM)and aging.However,most studies have focused on adipose-derived MSC-CM(ADMSC-CM),resulting in a research bias.We hypothesized that umbilical cord-derived MSCs,being younger than adipose-derived MSCs,would be more suitable for overcoming aging-related processes.AIM To assess the efficacy and safety of umbilical cord-derived MSC-CM(UCMSCCM)for preventing and treating skin aging.METHODS In vitro and in vivo studies were conducted to compare UCMSC-CM with ADMSC-CM,the most studied active aging-preventive conditioned medium to date.Additionally,the most effective delivery method of UCMSC-CM for aged skin was identified.RESULTS UCMSC-CM had a higher content of effective factors,stimulated higher proliferation of fibroblasts,and strongly inhibited melanin production in B16F1 cells.In aged mice,UCMSC-CM application increased skin thickness,the number of Ki-67-positive cells,and the area of collagen deposition.UCMSC-CM was more effective than ADMSC-CM in preventing and treating skin aging.Additionally,a safety evaluation of UCMSC-CM performed in various animal models indicated that it was safe even when used directly on the skin.CONCLUSION UCMSC-CM is effective and safe for preventing and treating skin aging.展开更多
Dear Editor,The Veterans Health Administration(VHA)plays a crucial role in the U.S.healthcare system,particularly for a population with a high prevalence of skin cancer[1].Timely total body skin examination(TBSE)is vi...Dear Editor,The Veterans Health Administration(VHA)plays a crucial role in the U.S.healthcare system,particularly for a population with a high prevalence of skin cancer[1].Timely total body skin examination(TBSE)is vital for managing cutaneous malignancies[2].Despite National Comprehensive Cancer Network(NCCN)guidelines advocating regular TBSE post-diagnosis[3].展开更多
Sepsis,a life-threatening condition,can lead to acute skin failure characterized by extensive skin damage.This is often due to decreased blood flow,inflammation,and increased susceptibility to infection.Acute skin fai...Sepsis,a life-threatening condition,can lead to acute skin failure characterized by extensive skin damage.This is often due to decreased blood flow,inflammation,and increased susceptibility to infection.Acute skin failure in people with sepsis is often associated with sleep disturbances,anxiety,and poor mood.Inflammatory markers and lactate levels correlate with these psychiatric symptoms,suggesting a link between skin and brain function.The skin and the central nervous system(CNS)have bidirectional communication.The CNS is also in close contact with the digestive tract.The gut,skin,and brain influence each other’s functions thr-ough nervous,hormonal,and immune pathways,forming a gut-skin-brain axis.Understanding the interaction among the gut,skin,and CNS is critical to the diag-nosis and treatment of various skin and neurological disorders.By recognizing individual variations in gut microbiota,immune responses,and neural pathways,treatments can be tailored to specific patient needs,enhancing efficacy and minimizing side effects.The gut plays a large role in mental health.Under-standing the gut skin brain axis,will lead to improved mental health outcomes.展开更多
Background:The use of skincare cosmetics can enhance human skin integrity,appearance,and conditions.However,consumers nowadays are quite concerned about the efficacy of skincare cosmetics,particularly those with antio...Background:The use of skincare cosmetics can enhance human skin integrity,appearance,and conditions.However,consumers nowadays are quite concerned about the efficacy of skincare cosmetics,particularly those with antioxidant properties that can improve skin tone and skin health.Previous studies also reported that volatile organic compounds(VOCs)in skincare cosmetics could have beneficial effects on human skin.Objective:This research aims to evaluate the antioxidant properties of CHARMS^(TM)skincare cosmetics as well as to investigate the presence of VOCs that could influence their skin tone improvement properties.Material and methods:The CHARMS^(TM)products used were cleanser,toner,essence,serum,moisturizer,scrub,and night cream.The skin tone improvement was assessed on 20 female volunteers’facial skin by using a colorimeter.The antioxidant properties were evaluated by 2,2-diphenyl-1-picrylhydrazyl(DPPH)free radical scavenging assay,total phenolic content(TPC),and total flavonoid content(TFC).Meanwhile,the VOCs were measured using an electronic nose based on gas chromatography(e-nose-GC).Results:The findings show that skin tone was improved significantly by 3.23%in which the skin becomes lighter while skin redness was reduced by 5.75%after using the CHARMS^(TM)skincare cosmetics.The results also show that the cleanser(21.55±0.23%)and the serum(23.60±0.19%)had the highest DPPH radical scavenging activity.Contrarily,the moisturizer exhibited the highest TPC value(324.14±17.47 mg GAE/g),and the cleanser had the highest TFC value(24.68±1.57 mg QE/g).The VOCs detected in these skincare cosmetics such as limonene andγ-terpinene may have skin-lightening effects.Conclusion:It can be concluded that the tested products from CHARMS^(TM)skincare cosmetics comply with the standard regulations and guidelines for Control of Cosmetic Products in Malaysia and can be used effectively as a daily skincare routine.展开更多
The random nanofiber distribution in traditional electrospun membranes restricts the pressure sensing sensitivity and measurement range of electronic skin.Moreover,current multimodal sensing suffers from issues like o...The random nanofiber distribution in traditional electrospun membranes restricts the pressure sensing sensitivity and measurement range of electronic skin.Moreover,current multimodal sensing suffers from issues like overlapping signal outputs and slow response.Herein,a novel electrospinning method is proposed to prepare double-coupled microstructured nanofibrous membranes.Through the effect of high voltage electrostatic field in the electrospinning,the positively charged nanofibers are preferentially attached to the negatively charged foam surface,forming the ordered two-dimensional honey-comb porous nanofibrous membrane with three-dimensional spinous microstructure.Compared with the conventional random porous nanofibrous membrane,the bionic two-dimensional honeycomb and three-dimensional spinous dual-coupled microstructures in the ordered porous nanofibrous membrane endows the electronic skin with significantly improved mechanical properties(maximum tensile strain increased by 77%and fatigue resistance increased by 35%),air permeability(water vapor transmission rate increased by 16%)and sensing properties(pressure sensitivity increased by 276%and detection range increased by 137%).Furthermore,the electronic skin was constructed by means of a conformal composite ionic liquid functionalized nanofibrous membrane,and the real-time and interference-free dualsignal monitoring of pressure and temperature(maxi-mum temperature coefficient of resistance:−0.918°C^(−1))was realized.展开更多
The Baumann Skin Typing System diagnoses patients as having one of 16 skin types based on their answers to a validated questionnaire [i] known as the Baumann Skin Type Indicator [ii]. The BSTI questionnaire has been t...The Baumann Skin Typing System diagnoses patients as having one of 16 skin types based on their answers to a validated questionnaire [i] known as the Baumann Skin Type Indicator [ii]. The BSTI questionnaire has been tested over the last decade on over 200,000 people of various ages and ethnicities in different geographic locations around the world. In this study, data were collected from 52,862 patients to compare skin type prevalence between those who presented to doctor’s offices and those who took the quiz without supervision online. The most common skin types varied only slightly between patients that took the quiz online and those that completed the questionnaire in their doctor’s office. This indicates that the prevalence of skin types seen in the doctor’s office is similar to that in the general population and that supervision is not necessary to get an accurate result on the BSTI. [iii] In addition, comparison of data gathered in China, Korea, and the US did not show a significant difference in skin type prevalence between Asian and Caucasian skin types. [iv] This study demonstrates that the English version of the BSTI is valid for English speaking patients online, and in doctors’ offices in the US, China and Korea.展开更多
基金supported by the Shaanxi Qinchuang Yuan“scientist+engineer”team construction(No.2023KXJ-080)Shaanxi Chiral Drug Engineering Technology Research Center(Department of Science and Technology of Shaanxi Province.No.[2011]-251).
文摘Background:Human skin is affected by ultraviolet rays on a daily basis,and excessive ultraviolet radiation(UVR)can lead to sunburn erythema,tanning,photoaging,and skin tumors.The combination of Astragali Radix(AR)and Anemarrhenae Rhizoma(AAR)is a common pairing in traditional Chinese medicine(TCM).According to earlier studies,they possess properties capable of alleviating the adverse impacts of UVR on the skin.However,the specific actions and underlying mechanisms require further investigation.The study aims to analyze the efficacy of AR-AAR in preventing UVR-induced skin damage and to clarify the associated molecular mechanisms.Methods:Potential signaling pathways by which AR and AAR may protect against UVR-induced skin damage were identified with network pharmacology,molecular docking techniques and molecular dynamics(MD)simulation.Except the normal group,the back skin of SD rats was exposed to 1.1 mW/cm^(2) UVA combined with 0.1 mW/cm^(2) UVB daily,and the UVR skin damage model was established.Morphological features of skin tissues of different groups were discovered through Hematoxylin and Eosin(HE)staining,Masson staining,Weigert staining.ELISA was utilized to measure the levels of reactive oxygen species(ROS),Interleukin 6(IL-6),Interleukin 1β(IL-1β)and Tumor necrosis factos-α(TNF-α)in skin tissues.RT-PCR and Western blot were employed to quantify the mRNA and protein contents of PI3K,AKT,and MMP-9.Results:Network pharmacology analysis predicts that AR-AAR may improve skin damage induced by UVR through the PI3K/AKT signaling pathway.Histological staining shows that AR-AAR can significantly reduce inflammatory infiltration and fibrosis in damaged skin.Treatment with AR-AAR(2:1)significantly reduced the expression levels of IL-1β,IL-6,TNF-αand ROS in UVR-damaged rat skin.After treatment with AR-AAR(2:1),not only did the relative mRNA expression levels of PI3K and AKT and the protein expression levels of PI3K,AKT,P-PI3K,and P-AKT increase,but the mRNA and protein expression levels of MMP-9 decreased.Conclusion:The study indicate that the AR-AAR combination and its active components may mitigate UVR skin damage by modulating the PI3K/AKT signaling pathway.
文摘Oats, frequently incorporated into skincare formulations for their anti-inflammatory, moisturizing, and barrier-repairing properties, may present an overlooked risk to individuals with celiac disease, particularly when applied to compromised skin. Although pure oats are inherently gluten-free, the widespread contamination with gluten-containing grains like wheat, barley, or rye during agricultural and processing stages introduces the potential for gluten exposure through topical application. This raises important questions about whether gluten proteins, when applied to damaged skin, might penetrate the epidermal barrier and contribute to immune responses in genetically predisposed celiac patients, given that even minute amounts of gluten can trigger systemic symptoms. Emerging evidence suggests that transdermal absorption of gluten peptides through impaired skin integrity might bypass the gastrointestinal route, yet the precise mechanisms and clinical significance of this pathway remain poorly understood. The role of compromised skin in facilitating gluten absorption and the possible activation of CD4+ T-cells, mimicking gastrointestinal pathways, warrants further investigation. Additionally, the ability of gluten peptides to reach deeper dermal layers and potentially enter the systemic circulation remains speculative, though theoretically possible in severely disrupted skin barriers. Without clinical and molecular studies to determine the risk of topical gluten exposure, particularly in celiac patients with skin injuries, there remains a potential for undetected immune activation and subsequent adverse health outcomes in this sensitive population.
文摘By recruiting 30 participants with striae gravidarum and using anti-wrinkle skincare products as an intervention measure,skin elasticity testing,skin firmness testing,and stretch mark image collection were conducted before use the anti-wrinkle skincare products,on the 14th,28th,and 56th day of use the antiwrinkle skincare products,respectively.Combined with visual evaluation by researchers and self-assessment by participants,the role of anti-wrinkle skincare products in improving stretch marks during pregnancy was explored.The results showed that on the 14th,28th,and 56th day of using efficacy skincare products,the average depth,area,and volume of stretch marks in the test area decreased compared to the baseline values before use and showed statistical differences(P<0.05);The measured values of R5 and R7 parameters for evaluating skin elasticity at the test site were significantly higher than the baseline values before use(P<0.05).On the 28th and 56th day of using efficacy skincare products,the measured values of the skin firmness evaluation parameters in the test area decreased significantly compared to the baseline values before use,and there was a statistical difference(P<0.05).The scores of the number,depth,and skin laxity of abdominal stretch marks in the visual assessment of the researchers and self-assessment of the subjects were significantly reduced on days 14,28,and 56 compared to before using the anti-wrinkle skincare product(P<0.05).This suggests that the anti-wrinkle skincare product has the effect of improving the elasticity and firmness of the skin in subjects with striae gravidarum,as well as improving striae gravidarum.
基金supported by National Institutes of Health Award(Nos.R01DE028614(I T O)and R21AR082668(I T O)),and 2236 CoCirculation2 of TUBITAK award(No.121C359(I T O))supported by The Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense,in the amount of($1986275)through the Peer Reviewed Medical Research Program under Award Number(No.HT9425-23-1-0487)。
文摘This comprehensive review explores the multifaceted landscape of skin bioprinting,revolutionizing dermatological research.The applications of skin bioprinting utilizing techniques like extrusion-,droplet-,laser-and light-based methods,with specialized bioinks for skin biofabrication have been critically reviewed along with the intricate aspects of bioprinting hair follicles,sweat glands,and achieving skin pigmentation.Challenges remain with the need for vascularization,safety concerns,and the integration of automated processes for effective clinical translation.The review further investigates the incorporation of biosensor technologies,emphasizing their role in monitoring and enhancing the wound healing process.While highlighting the remarkable progress in the field,critical limitations and concerns are critically examined to provide a balanced perspective.This synthesis aims to guide scientists,engineers,and healthcare providers,fostering a deeper understanding of the current state,challenges,and future directions in skin bioprinting for transformative applications in tissue engineering and regenerative medicine.
文摘<strong>Background:</strong> Previous studies have not specifically measured skin characteristics at common sites of pressure ulcers in high-risk elderly patients. Therefore, this study aimed to clarify the physiological skin characteristics at common pressure ulcer sites and their relationship with pressure ulcer risk and demographic/laboratory data in bedridden elderly Japanese patients. <strong>Methods:</strong> This study involved 55 elderly Japanese patients in a long-term care hospital and 25 female Japanese university students. Skin surface temperature, epidermal water content, transepidermal water loss, skin erythema/redness, skin elasticity, and skin thickness were measured using noninvasive devices. The sacral and both heel areas (sites predisposed to pressure ulcers) and mid-to-lower back area (control site) were observed. <strong>Results:</strong> Elderly patients showed a low epidermal water content at both heels (right heel, 14.8 ± 9.1 arbitrary units, AU.;left heel, 14.4 ± 8.3 AU). Transepidermal water loss remained acceptable at all sites in older patients despite the presence of dry skin (back, 7.1 ± 1.8 g/hm<sup>2</sup>;sacrum, 7.4 ± 3.0 g/hm<sup>2</sup>;right heel, 17.7 ± 7.1 g/hm<sup>2</sup>;left heel, 19.4 ± 8.1 g/hm<sup>2</sup>). Back (0.61 ± 0.13 AU) and sacral (0.67 ± 0.11 AU) skin elasticity and sacral skin thickness (0.97 ± 0.56 cm) were significantly lower than those of healthy young people (0.86 ± 0.04 AU, 0.87 ± 0.05 AU, and 2.27 ± 0.84 cm, respectively;<em>p</em> < 0.001 for all sites). Moderate positive correlations were observed between back skin elasticity and serum albumin level (r = 0.445, <em>p</em> < 0.001), and between sacral skin thickness and BMI (r = 0.506, <em>p</em> < 0.001) in older patients. <strong>Conclusions:</strong> Our findings showed that skin thickness and elasticity should be prioritized when evaluating pressure ulcer risk at the sacral region in bedridden elderly Japanese patients. Moreover, skin moisturization should be considered to minimize the risk at the heels in such patients.
基金supported by the National Natural Science Foundation,China(82103704).
文摘Currently,research on N^(6)-methyladenine(m^(6)A)is extensive in the field of oncology,while studies involving m^(6)A and skin diseases remain relatively limited.Based on existing reports,we searched PubMed and Web of Science for literature related to m^(6)A and dermatological conditions.Analysis of citation counts and journal impact factors revealed a significant upward trend in the volume of m^(6)A-related research.Term frequency analysis of titles and abstracts indicated that studies mainly focus on skin tumors and inflammatory or immune-related skin diseases,particularly melanoma,psoriasis,and skin development.Transcriptomic data from the Gene Expression Omnibus(GEO)were analyzed,revealing differential expression of m^(6)A-related genes in 4 types of skin tumors(including squamous cell carcinoma and basal cell carcinoma)as well as in inflammatory skin diseases such as psoriasis and atopic dermatitis,and potential mechanisms of action were also explored.Findings suggest that m^(6)A modifications exhibit heterogeneity between neoplastic and nonneoplastic skin diseases.However,the regulatory mechanisms of m^(6)A dynamic modifications on key genes involved in dermatological disorders remain unclear and warrant further investigation.
文摘The pervasive use of photo editing applications such as Photoshop and FaceTune has significantly altered societal beauty standards, particularly for individuals with skin of color, often leading to unrealistic expectations regarding skin appearance and health. These tools allow users to smooth skin textures, lighten skin tones, and erase imperfections, perpetuating Eurocentric beauty ideals that frequently marginalize the natural diversity of skin tones and textures. Consequently, individuals with skin of color may seek dermatological interventions—such as skin lightening treatments, aggressive acne scar revisions, and other cosmetic procedures—aimed at achieving appearances that align more closely with digitally manipulated images. This pursuit of an unattainable aesthetic can result in increased dissatisfaction with common skin conditions like hyperpigmentation and keloids, which are often misrepresented in edited photos. Additionally, the psychological impact of these alterations can exacerbate feelings of inadequacy, contributing to conditions such as anxiety and body dysmorphic disorder. Dermatologists face the dual challenge of addressing patients’ clinical needs while also managing their expectations shaped by digital enhancements. To combat this, it is essential for dermatologists to integrate patient education that emphasizes the beauty of diverse skin tones and the discrepancies between digital images and authentic skin health. By fostering an understanding of realistic outcomes and promoting the acceptance of natural skin characteristics, dermatologists can empower individuals with skin of color to prioritize authentic skin health over digitally influenced ideals, ultimately leading to more satisfying dermatological care and improved self-image.
文摘Skin cancer is the most prevalent cancer globally,primarily due to extensive exposure to Ultraviolet(UV)radiation.Early identification of skin cancer enhances the likelihood of effective treatment,as delays may lead to severe tumor advancement.This study proposes a novel hybrid deep learning strategy to address the complex issue of skin cancer diagnosis,with an architecture that integrates a Vision Transformer,a bespoke convolutional neural network(CNN),and an Xception module.They were evaluated using two benchmark datasets,HAM10000 and Skin Cancer ISIC.On the HAM10000,the model achieves a precision of 95.46%,an accuracy of 96.74%,a recall of 96.27%,specificity of 96.00%and an F1-Score of 95.86%.It obtains an accuracy of 93.19%,a precision of 93.25%,a recall of 92.80%,a specificity of 92.89%and an F1-Score of 93.19%on the Skin Cancer ISIC dataset.The findings demonstrate that the model that was proposed is robust and trustworthy when it comes to the classification of skin lesions.In addition,the utilization of Explainable AI techniques,such as Grad-CAM visualizations,assists in highlighting the most significant lesion areas that have an impact on the decisions that are made by the model.
基金supported by the Natural Science Foundation of Hebei Province(Grant number:C2025405060).
文摘Skin cutaneous melanoma(SKCM),a highly invasive malignant tumor originating from skin melanocytes,poses a significant threat to public health[1,2].Its development is closely associated with multiple factors,such as ultraviolet radiation,gene mutations,and immune escape.Among these,imbalance in the immune surveillance and clearance of tumor cells is a crucial link to disease progression[3,4].Tripartite motif-containing 27,which belongs to the TRIM protein family and is encoded by the TRIM27 gene,contains the RING,B-box,and coiled-coil domains.It participates in biological processes such as cell-cycle regulation,signal transduction,and immune response mainly by modifying target proteins through ubiquitination.Notably,increasing evidence indicates that TRIM27 is closely associated with the tumor immune microenvironment and contributes to cancer immune escape via multiple mechanisms,thereby promoting tumor development[5].However,the role of TRIM27 in SKCM remains unclear,thus prompting our investigation to elucidate this.
基金supported by the National Natural Science Foundation of China(Grant Nos.82073439 and 82373475)。
文摘Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface chemistry.This feature makes them appropriate for use as functional and biocompatible nano-formulations.By optimizing the absorption of longitudinally localized surface plasmon resonance in the near-infrared region,which corresponds to the near-infrared bio-tissue window,GNRs with appropriate modifications may improve the results of photothermal treatment(PTT).In dermatology,potential noninvasive uses of GNRs to enhance wound healing,manage infections,combat cutaneous malignancies,and remodel skin tissues via PTT have attracted research attention in recent years.The review discussed the basic properties of GNRs,such as their shape,size,optical performance,photothermal efficiency,and metabolism.Then,the disadvantages of using these particles in photodynamic therapy are highlighted.Next,biological applications of GNRs-based PTT are explored in detail.Finally,the limitations and future perspectives of this research are addressed,providing a comprehensive perspective on the potential GNRs with PTT.
文摘Mitochondria are not only the main source of cellular energy but also participate in regulating key physiological processes such as intracellular oxidative stress,signal transduction,and apoptosis,which are crucial for maintaining the structure and function of the skin.Increasing evidence suggests that abnormalities in mitochondrial structure,function,and regulation are closely related to the occurrence and development of skin photoaging.However,the critical role of mitochondria in skin photoaging has yet to be thoroughly explored and studied.In this review,we summarize the roles of mitochondria in the occurrence and development of skin photoaging,aiming to provide new ideas and methods for the prevention and treatment of skin photoaging.
文摘BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients often experience bad moods,sleep disorders,and other health issues.Despite recognizing these factors,no studies have examined the correlation between inflammatory factors,lactic acid levels,ASF,mood disturbances,and sleep quality in critically ill patients.We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality,which may inform clinical treatment for septic shock and ASF.AIM To explore the relationship between inflammatory factors,lactic acid levels,the severity of ASF,bad mood,and sleep quality.METHODS The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University,categorized into ASF(n=35)or non-ASF groups(n=115).We compared the peripheral blood inflammatory factors,including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),lactic acid levels,skin mottling score(SMS),modified early warning score(MEWS),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and Pittsburgh sleep quality index(PSQI)scores.Pearson correlation analysis assessed relationships among these variables.RESULTS The ASF group had significantly higher levels of CRP(19.60±4.10 vs 15.30±2.96 mg/mL),IL-6(298.65±48.65 vs 268.66±33.66 pg/L),procalcitonin,lactic acid(8.42±2.32 vs 5.70±1.27 mmol/L),SMS[0(0,1)vs 3(2,3)],MEWS(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),and PSQI scores(14.23±3.94 vs 8.69±2.46)compared with the non-ASF group(all P<0.001).Pearson correlation analysis revealed that IL-6,CRP,TNF-α,and lactic acid were positively correlated with SMS,MEWS,SAS,SDS,and PSQI scores(P<0.05).CONCLUSION Peripheral blood levels of IL-6,CRP,TNF-α,and lactic acid correlate positively with SMS,MEWS,SAS,SDS,and PSQI in critically ill patients with ASF.
基金Project(52325905) supported by the National Natural Science Foundation of ChinaProjects(DJ-HXGG-2023-04, DJHXGG-2023-16) supported by the Key Technology Research Projects of Power China。
文摘Plum blossom pile is a new type of special-shaped pile, which is proposed based on the principle of maximum perimeter with the same cross-sectional area. To advance this technique, primarily for the design of plum blossom piles, it is important to investigate the skin friction behavior of plum blossom pile foundations precluding any straightforward constitutive model. In this work, an analytic method dependent on the cross-sectional geometry and the vertical shearing effects is proposed by means of equilibrium analysis to calculate the effective vertical stress in the surrounding soil, the skin friction/negative skin friction, and the axial force/dragload of a plum blossom pile. Additionally, the curves of skin friction of piles are investigated with the same conditions. The results show that the curves of skin friction of piles deduced according to the developed analytic method agree well with the FEM results and related literature solution, which validates the solution. The axial force of the pile decreases with the increase of the shear action coefficient in the buried depth direction under the vertical concentrated load when considering the vertical shearing effects on the pile-soil interfaces.
基金financially supported by the National Key Research and Development Program of China(#2022YFD1800701)the Key Research and Development Program of the Ningxia Hui Autonomous Region(#2021BEF02028)the Chinese Agricultural Research System of MOF and MARA(#CARS-37).
文摘Lumpy skin disease(LSD)is a highly contagious disease caused by lumpy skin disease virus(LSDV)in bovines.Rapid and accurate diagnosis is very important to controll it.However,current commercial detection kits need to be improved in terms of sensitivity or specificity.This study aimed to develop a novel diagnostic competitive enzyme-linked immunosorbent assay(cELISA)based on the newly identified antigen gene LSDV034.The rLSDV034 protein was identified as a potential diagnostic antigen,and it was expressed,purified,and used to immunize BALB/c mice.Using laboratory-prepared indirect ELISA(iELISA),the positive cell lines were screened,and their blocking activity was further verified by competitive ELISA(cELISA).The cell line,1H7,was chosen to produce mouse ascites,which were purified for a monoclonal antibody(mAb,5.395 mg/mL).The heavy chain type of the 1H7 mAb was identified as IgG1a,and its light chain subtype was identified as κ.Furthermore,cELISA was developed to detect bovine serum antibodies,with rLSDV034(4μg/mL)as the coating antigen and HRP-1H7 mAb(1:300)as the competitive antibody.The cutoff value of cELISA was 55%,based on 32 negative bovine serum samples.The analytical sensitivity was 1:8,and no cross-reaction was detected with bovine viral diarrhea virus(BVDV),infectious bovine rhinotracheitis virus(IBRV),Pasteurella multocida(P.multocida),or Mycoplasma bovis(M.bovis)from the serum samples.The diagnostic sensitivity and specificity of cELISA were 98.46%(95%confidence interval,CI:91.7–100)and 100%(95%CI:89.1–100),respectively,based on the analysis of 30 LSDV-infected bovine serum samples,35 GTPV-vaccinated samples,and 32 negative samples.The overall coincidence of the cELISA with the virus neutralization test(VNT)reached 98.97%(95%CI:94.4–100).Furthermore,we used cELISA to analyze 230 clinical bovine serum samples(including 59 infected and 171 vaccinated samples)and found that the serum positivity rates of the immunized samples(on d 60 postimmunization)and infected samples were 77.78%(95%CI:70.8–83.8%)and 71.19%(95%CI:57.9–82.2),respectively.These results indicate that the developed cELISA is promising for detecting serum antibodies in naturally infected or vaccinated cattle.
文摘BACKGROUND Research has been increasingly conducted on the connection between mesenchymal stem cell(MSC)-conditioned medium(MSC-CM)and aging.However,most studies have focused on adipose-derived MSC-CM(ADMSC-CM),resulting in a research bias.We hypothesized that umbilical cord-derived MSCs,being younger than adipose-derived MSCs,would be more suitable for overcoming aging-related processes.AIM To assess the efficacy and safety of umbilical cord-derived MSC-CM(UCMSCCM)for preventing and treating skin aging.METHODS In vitro and in vivo studies were conducted to compare UCMSC-CM with ADMSC-CM,the most studied active aging-preventive conditioned medium to date.Additionally,the most effective delivery method of UCMSC-CM for aged skin was identified.RESULTS UCMSC-CM had a higher content of effective factors,stimulated higher proliferation of fibroblasts,and strongly inhibited melanin production in B16F1 cells.In aged mice,UCMSC-CM application increased skin thickness,the number of Ki-67-positive cells,and the area of collagen deposition.UCMSC-CM was more effective than ADMSC-CM in preventing and treating skin aging.Additionally,a safety evaluation of UCMSC-CM performed in various animal models indicated that it was safe even when used directly on the skin.CONCLUSION UCMSC-CM is effective and safe for preventing and treating skin aging.
文摘Dear Editor,The Veterans Health Administration(VHA)plays a crucial role in the U.S.healthcare system,particularly for a population with a high prevalence of skin cancer[1].Timely total body skin examination(TBSE)is vital for managing cutaneous malignancies[2].Despite National Comprehensive Cancer Network(NCCN)guidelines advocating regular TBSE post-diagnosis[3].
文摘Sepsis,a life-threatening condition,can lead to acute skin failure characterized by extensive skin damage.This is often due to decreased blood flow,inflammation,and increased susceptibility to infection.Acute skin failure in people with sepsis is often associated with sleep disturbances,anxiety,and poor mood.Inflammatory markers and lactate levels correlate with these psychiatric symptoms,suggesting a link between skin and brain function.The skin and the central nervous system(CNS)have bidirectional communication.The CNS is also in close contact with the digestive tract.The gut,skin,and brain influence each other’s functions thr-ough nervous,hormonal,and immune pathways,forming a gut-skin-brain axis.Understanding the interaction among the gut,skin,and CNS is critical to the diag-nosis and treatment of various skin and neurological disorders.By recognizing individual variations in gut microbiota,immune responses,and neural pathways,treatments can be tailored to specific patient needs,enhancing efficacy and minimizing side effects.The gut plays a large role in mental health.Under-standing the gut skin brain axis,will lead to improved mental health outcomes.
基金funded by Universiti Tun Hussein Onn Malaysia(UTHM)under Industrial Grant,M066 together with Matching Grant,Q003.
文摘Background:The use of skincare cosmetics can enhance human skin integrity,appearance,and conditions.However,consumers nowadays are quite concerned about the efficacy of skincare cosmetics,particularly those with antioxidant properties that can improve skin tone and skin health.Previous studies also reported that volatile organic compounds(VOCs)in skincare cosmetics could have beneficial effects on human skin.Objective:This research aims to evaluate the antioxidant properties of CHARMS^(TM)skincare cosmetics as well as to investigate the presence of VOCs that could influence their skin tone improvement properties.Material and methods:The CHARMS^(TM)products used were cleanser,toner,essence,serum,moisturizer,scrub,and night cream.The skin tone improvement was assessed on 20 female volunteers’facial skin by using a colorimeter.The antioxidant properties were evaluated by 2,2-diphenyl-1-picrylhydrazyl(DPPH)free radical scavenging assay,total phenolic content(TPC),and total flavonoid content(TFC).Meanwhile,the VOCs were measured using an electronic nose based on gas chromatography(e-nose-GC).Results:The findings show that skin tone was improved significantly by 3.23%in which the skin becomes lighter while skin redness was reduced by 5.75%after using the CHARMS^(TM)skincare cosmetics.The results also show that the cleanser(21.55±0.23%)and the serum(23.60±0.19%)had the highest DPPH radical scavenging activity.Contrarily,the moisturizer exhibited the highest TPC value(324.14±17.47 mg GAE/g),and the cleanser had the highest TFC value(24.68±1.57 mg QE/g).The VOCs detected in these skincare cosmetics such as limonene andγ-terpinene may have skin-lightening effects.Conclusion:It can be concluded that the tested products from CHARMS^(TM)skincare cosmetics comply with the standard regulations and guidelines for Control of Cosmetic Products in Malaysia and can be used effectively as a daily skincare routine.
基金supported by the National Natural Science Foundation of China(No.52275191)the Major Program of the National Natural Science Foundation of China for Basic Theory and Key Technology of Tri-Co Robots(No.92248301)the 333 Project of Jiangsu Province and Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_3622).
文摘The random nanofiber distribution in traditional electrospun membranes restricts the pressure sensing sensitivity and measurement range of electronic skin.Moreover,current multimodal sensing suffers from issues like overlapping signal outputs and slow response.Herein,a novel electrospinning method is proposed to prepare double-coupled microstructured nanofibrous membranes.Through the effect of high voltage electrostatic field in the electrospinning,the positively charged nanofibers are preferentially attached to the negatively charged foam surface,forming the ordered two-dimensional honey-comb porous nanofibrous membrane with three-dimensional spinous microstructure.Compared with the conventional random porous nanofibrous membrane,the bionic two-dimensional honeycomb and three-dimensional spinous dual-coupled microstructures in the ordered porous nanofibrous membrane endows the electronic skin with significantly improved mechanical properties(maximum tensile strain increased by 77%and fatigue resistance increased by 35%),air permeability(water vapor transmission rate increased by 16%)and sensing properties(pressure sensitivity increased by 276%and detection range increased by 137%).Furthermore,the electronic skin was constructed by means of a conformal composite ionic liquid functionalized nanofibrous membrane,and the real-time and interference-free dualsignal monitoring of pressure and temperature(maxi-mum temperature coefficient of resistance:−0.918°C^(−1))was realized.
文摘The Baumann Skin Typing System diagnoses patients as having one of 16 skin types based on their answers to a validated questionnaire [i] known as the Baumann Skin Type Indicator [ii]. The BSTI questionnaire has been tested over the last decade on over 200,000 people of various ages and ethnicities in different geographic locations around the world. In this study, data were collected from 52,862 patients to compare skin type prevalence between those who presented to doctor’s offices and those who took the quiz without supervision online. The most common skin types varied only slightly between patients that took the quiz online and those that completed the questionnaire in their doctor’s office. This indicates that the prevalence of skin types seen in the doctor’s office is similar to that in the general population and that supervision is not necessary to get an accurate result on the BSTI. [iii] In addition, comparison of data gathered in China, Korea, and the US did not show a significant difference in skin type prevalence between Asian and Caucasian skin types. [iv] This study demonstrates that the English version of the BSTI is valid for English speaking patients online, and in doctors’ offices in the US, China and Korea.
