In this paper,a parametric method of site error estimation is developed for a lightning location system (LLS) which consists of three or more direction finders (DFs) and one position analyzer (PA). The site error for ...In this paper,a parametric method of site error estimation is developed for a lightning location system (LLS) which consists of three or more direction finders (DFs) and one position analyzer (PA). The site error for each DF is a function of bearings measured by the DF, and is assumed to be limited-term harmonics. The problem of site error estimation is reduced to a non-linear unconstrained minimization problem by employing the eigen technique (Orville Jr., 1987). The site error can be found directly by minimizing the objective function. By using the data set obtained with the LLS of three DFs in Beijing area during the summer of 1988, the site error correction curves for all DFs were found. About 4900 lightning flashes detected by the three DFs were used. The results showed that about 95% of the flash residuals of the sample were within ± 1 degree after corrections. The lightning locations with site error corrections were more consistent with the corresponding radar echoes than those without corrections.展开更多
Surgical error due to incorrect identification of the surgical site has been known to occur right from the beginning of surgical practice through the ages. However, increasing awareness, preventative efforts and risks...Surgical error due to incorrect identification of the surgical site has been known to occur right from the beginning of surgical practice through the ages. However, increasing awareness, preventative efforts and risks of litigation have not eliminated this problem. Cutaneous surgery for skin cancer makes up a large proportion of procedures performed each year and it is often difficult to correctly identify biopsy sites, especially as this is not easy in sun-damaged skin. In this review article, we review the incidence of wrong-site surgery, measures taken by professional bodies, and the use of photography and newer technologies in an attempt to eliminate this distressing event in the field of plastic and dermatologic surgery. The purpose of this review is to highlight the incidence of such surgical site identification errors, evaluate the risk factors, and educate the surgeon about measures that can be undertaken to avoid being faced with such a situation.展开更多
目前的勘探方案预期效果评价指标常未能反映物理过程且参数较难确定.此外,勘探方案优化框架中的勘探点布置策略往往依赖位置关系并需事先确定勘探范围.为解决上述问题,以不排水抗剪强度参数为例,提出并采用安全系数的均方根误差折减率期...目前的勘探方案预期效果评价指标常未能反映物理过程且参数较难确定.此外,勘探方案优化框架中的勘探点布置策略往往依赖位置关系并需事先确定勘探范围.为解决上述问题,以不排水抗剪强度参数为例,提出并采用安全系数的均方根误差折减率期望(expected reduction rate of the root mean square error,ERRS)量化因融合参考勘探数据而导致的安全系数评估结果向参考安全系数集中效果的期望提升程度,并将其作为勘探方案预期效果评价的指标.此外,结合该指标和贪心算法构建了以优化勘探位置和数量为目的的勘探方案优化框架.ERRS指标计算过程采用乔列斯基分解中点法和改进贝叶斯更新方法离散参数完全及条件随机场实现,并基于多重二阶响应面代理模型替代确定性空间变异边坡稳定性分析,有效提高指标计算精度和效率.不排水饱和黏土边坡案例显示:提出的ERRS指标能够在无需确定复杂参数的情况下,获得与其他指标接近的评价结果;所构建的勘探方案优化框架能够在不事先确定勘探范围的情况下,得到指定勘探数量下更优的勘探点布置,进而获得更节省成本且预期效果较好的勘探方案.提出的指标和优化框架可为实际边坡工程场地勘探方案评价及优化设计提供参考.展开更多
Post-translational modification (PTM) increases the functional diversity of proteins by introducing new functional groups to the side chain of amino acid of a protein. Among all amino acid residues, the side chain of ...Post-translational modification (PTM) increases the functional diversity of proteins by introducing new functional groups to the side chain of amino acid of a protein. Among all amino acid residues, the side chain of lysine (K) can undergo many types of PTM, called K-PTM, such as “acetylation”, “crotonylation”, “methylation” and “succinylation” and also responsible for occurring multiple PTM in the same lysine of a protein which leads to the requirement of multi-label PTM site identification. However, most of the existing computational methods have been established to predict various single-label PTM sites and a very few have been developed to solve multi-label issue which needs further improvement. Here, we have developed a computational tool termed mLysPTMpred to predict multi-label lysine PTM sites by 1) incorporating the sequence-coupled information into the general pseudo amino acid composition, 2) balancing the effect of skewed training dataset by Different Error Cost method, and 3) constructing a multi-label predictor using a combination of support vector machine (SVM). This predictor achieved 83.73% accuracy in predicting the multi-label PTM site of K-PTM types. Moreover, all the experimental results along with accuracy outperformed than the existing predictor iPTM-mLys. A user-friendly web server of mLysPTMpred is available at http://research.ru.ac.bd/mLysPTMpred/.展开更多
为了满足三站时差(Time Difference of Arrival,TDOA)定位系统对定位精度的要求,论述了三站时差定位原理。用几何稀释精度(Geometric Dilution of Precision,GDOP)分析定位精度并做了仿真。对仿真结果进行分析,讨论站址测量误差和时差...为了满足三站时差(Time Difference of Arrival,TDOA)定位系统对定位精度的要求,论述了三站时差定位原理。用几何稀释精度(Geometric Dilution of Precision,GDOP)分析定位精度并做了仿真。对仿真结果进行分析,讨论站址测量误差和时差定位误差对定位精度的影响,提出要满足时差定位精度要求所需要达到的站址测量误差和时差测量误差指标,以及在工程实现中提高时差定位精度的方法。展开更多
文摘In this paper,a parametric method of site error estimation is developed for a lightning location system (LLS) which consists of three or more direction finders (DFs) and one position analyzer (PA). The site error for each DF is a function of bearings measured by the DF, and is assumed to be limited-term harmonics. The problem of site error estimation is reduced to a non-linear unconstrained minimization problem by employing the eigen technique (Orville Jr., 1987). The site error can be found directly by minimizing the objective function. By using the data set obtained with the LLS of three DFs in Beijing area during the summer of 1988, the site error correction curves for all DFs were found. About 4900 lightning flashes detected by the three DFs were used. The results showed that about 95% of the flash residuals of the sample were within ± 1 degree after corrections. The lightning locations with site error corrections were more consistent with the corresponding radar echoes than those without corrections.
文摘Surgical error due to incorrect identification of the surgical site has been known to occur right from the beginning of surgical practice through the ages. However, increasing awareness, preventative efforts and risks of litigation have not eliminated this problem. Cutaneous surgery for skin cancer makes up a large proportion of procedures performed each year and it is often difficult to correctly identify biopsy sites, especially as this is not easy in sun-damaged skin. In this review article, we review the incidence of wrong-site surgery, measures taken by professional bodies, and the use of photography and newer technologies in an attempt to eliminate this distressing event in the field of plastic and dermatologic surgery. The purpose of this review is to highlight the incidence of such surgical site identification errors, evaluate the risk factors, and educate the surgeon about measures that can be undertaken to avoid being faced with such a situation.
文摘目前的勘探方案预期效果评价指标常未能反映物理过程且参数较难确定.此外,勘探方案优化框架中的勘探点布置策略往往依赖位置关系并需事先确定勘探范围.为解决上述问题,以不排水抗剪强度参数为例,提出并采用安全系数的均方根误差折减率期望(expected reduction rate of the root mean square error,ERRS)量化因融合参考勘探数据而导致的安全系数评估结果向参考安全系数集中效果的期望提升程度,并将其作为勘探方案预期效果评价的指标.此外,结合该指标和贪心算法构建了以优化勘探位置和数量为目的的勘探方案优化框架.ERRS指标计算过程采用乔列斯基分解中点法和改进贝叶斯更新方法离散参数完全及条件随机场实现,并基于多重二阶响应面代理模型替代确定性空间变异边坡稳定性分析,有效提高指标计算精度和效率.不排水饱和黏土边坡案例显示:提出的ERRS指标能够在无需确定复杂参数的情况下,获得与其他指标接近的评价结果;所构建的勘探方案优化框架能够在不事先确定勘探范围的情况下,得到指定勘探数量下更优的勘探点布置,进而获得更节省成本且预期效果较好的勘探方案.提出的指标和优化框架可为实际边坡工程场地勘探方案评价及优化设计提供参考.
文摘Post-translational modification (PTM) increases the functional diversity of proteins by introducing new functional groups to the side chain of amino acid of a protein. Among all amino acid residues, the side chain of lysine (K) can undergo many types of PTM, called K-PTM, such as “acetylation”, “crotonylation”, “methylation” and “succinylation” and also responsible for occurring multiple PTM in the same lysine of a protein which leads to the requirement of multi-label PTM site identification. However, most of the existing computational methods have been established to predict various single-label PTM sites and a very few have been developed to solve multi-label issue which needs further improvement. Here, we have developed a computational tool termed mLysPTMpred to predict multi-label lysine PTM sites by 1) incorporating the sequence-coupled information into the general pseudo amino acid composition, 2) balancing the effect of skewed training dataset by Different Error Cost method, and 3) constructing a multi-label predictor using a combination of support vector machine (SVM). This predictor achieved 83.73% accuracy in predicting the multi-label PTM site of K-PTM types. Moreover, all the experimental results along with accuracy outperformed than the existing predictor iPTM-mLys. A user-friendly web server of mLysPTMpred is available at http://research.ru.ac.bd/mLysPTMpred/.
文摘为了满足三站时差(Time Difference of Arrival,TDOA)定位系统对定位精度的要求,论述了三站时差定位原理。用几何稀释精度(Geometric Dilution of Precision,GDOP)分析定位精度并做了仿真。对仿真结果进行分析,讨论站址测量误差和时差定位误差对定位精度的影响,提出要满足时差定位精度要求所需要达到的站址测量误差和时差测量误差指标,以及在工程实现中提高时差定位精度的方法。
