The acoustic properties of anechoic layers with a singly periodic array of cylindrical scatterers are investigated. A method combined plane wave expansion and finite element analysis is extended for out-of-plane incid...The acoustic properties of anechoic layers with a singly periodic array of cylindrical scatterers are investigated. A method combined plane wave expansion and finite element analysis is extended for out-of-plane incidence. The reflection characteristics of the anechoic layers with cavities and locally resonant scatterers are discussed. The backing is a steel plate followed by an air half space. Under this approximate zero transmission backing condition, the reflection reduction is induced by the absorption enhancement. The absorption mechanism is explained by the scattering/absorption cross section of the isolated scatterer. Three types of resonant modes which can induce efficient absorption are revealed. Due to the fact that the frequencies of the resonant modes are related to the size of the scatterers, anechoic layers with scatterers of mixed size can broaden the absorption band. A genetic optimization algorithm is adopted to design the anechoic layer with scatterers of mixed size at a desired frequency band from 2 kHz to l0 kHz for normal incidence, and the influence of the incident angle is also discussed.展开更多
We report a low noise continuous-wave （CW） single-frequency 1.5-μm laser source obtained by a singly resonant optical parametric oscillator （SRO） based on periodically poled lithium niobate （PPLN）. The SRO was ...We report a low noise continuous-wave （CW） single-frequency 1.5-μm laser source obtained by a singly resonant optical parametric oscillator （SRO） based on periodically poled lithium niobate （PPLN）. The SRO was pumped by a CW single-frequency Nd：YVO4 laser at 1.06μm. The 1.02 W of CW single-frequency signal laser at 1.5 μm was obtained at pump power of 6 W. At the output power of around 0.75 W, the power stability was better than ±l.5% and no mode-hopping was observed in 30 min and frequency stability was better than 8.5 MHz in 1 min. The signal wavelength could be tuned from 1.57 to 1.59 μm by varying the PPLN temperature. The 1.5-μm laser exhibits low noise characteristics, the intensity noise of the laser reaches the shot noise limit （SNL） at an analysis frequency of 4 MHz and the phase noise is less than 1 dB above the SNL at analysis frequencies above 10 MHz.展开更多
Linked partitions were introduced by Dykema(Dykema K J. Multilinear function series and transforms in free probability theory. Adv. Math., 2005, 208(1):351–407) in the study of the unsymmetrized T-transform in free p...Linked partitions were introduced by Dykema(Dykema K J. Multilinear function series and transforms in free probability theory. Adv. Math., 2005, 208(1):351–407) in the study of the unsymmetrized T-transform in free probability theory.Permutation is one of the most classical combinatorial structures. According to the linear representation of linked partitions, Chen et al.(Chen W Y C, Wu S Y J, Yan C H. Linked partitions and linked cycles. European J. Combin., 2008, 29(6): 1408–1426) de?ned the concept of singly covered minimal elements. Let L(n, k) denote the set of linked partitions of [n] with k singly covered minimal elements and let P(n, k) denote the set of permutations of [n] with k cycles. In this paper, we mainly establish two bijections between L(n, k) and P(n, k). The two bijections from a different perspective show the one-to-one correspondence between the singly covered minimal elements in L(n, k) and the cycles in P(n, k).展开更多
Bi-f-harmonic maps are the critical points of bi-f-energy functional. This class of maps tends to integrate bi-harmonic maps and f-harmonic maps. In this paper, we show that bi-f-harmonic maps are not only an extensio...Bi-f-harmonic maps are the critical points of bi-f-energy functional. This class of maps tends to integrate bi-harmonic maps and f-harmonic maps. In this paper, we show that bi-f-harmonic maps are not only an extension of f-harmonic maps but also an extension of bi-harmonic maps, and that there should exist many examples of proper bi-f-harmonic maps. In order to find some concrete examples of proper bi-f-harmonic maps, we study the basic properties of bi-f-harmonic maps from two directions which are conformal maps between the same dimensionM manifolds and some special maps from or into a warped product manifold.展开更多
We report on the generation of self-oscillations from a continuously pumped singly resonant frequency doubler based on a periodically poled potassium titanyl phosphate crystal （PPKTP）. The sustained square-wave and ...We report on the generation of self-oscillations from a continuously pumped singly resonant frequency doubler based on a periodically poled potassium titanyl phosphate crystal （PPKTP）. The sustained square-wave and staircase curve of self-oscillations are obtained when the incident pump powers are below and above the threshold of subharmonic-pumped parametric oscillation （SPO）, respectively. The self-oscillations can be explained by the competition between the phase shifts induced by cascading nonlinearity and thermal effect, and the influence of fundamental nonlinear phase shift by the generation of SPO. The simulation results are in good agreement with the experiment data.展开更多
The establishment of an approach to design tunable yellow emission through singly doped single-phased phosphors to obtain white LED-based InGaN chip was reported. BaY2–xS4：xHo3＋ phosphors were prepared by the high ...The establishment of an approach to design tunable yellow emission through singly doped single-phased phosphors to obtain white LED-based InGaN chip was reported. BaY2–xS4：xHo3＋ phosphors were prepared by the high temperature solid state reaction and characterized by X-ray diffraction and photoluminescence spectra. Under the excitation of 465 nm,the emission spectra of these phosphors exhibited three sharp emission lines peaked at about 492,543 and 661 nm of Ho3＋ corresponding to 5F3,5F4 （5S2） and 5F5→5I8 transitions,respectively,with comparable intensities,resulting in a yellow light emission. The luminescence mechanism for Ho3＋ in BaY2S4 was explained.展开更多
By taking full account of the non-orthogonality of the orbitals between the low-lying doubly excited states ^1po and the singly excited states ^1S^e and ^1D^e of He, the corresponding radiative decay rates have been i...By taking full account of the non-orthogonality of the orbitals between the low-lying doubly excited states ^1po and the singly excited states ^1S^e and ^1D^e of He, the corresponding radiative decay rates have been investigated theoretically via analytic generalized Laguerre-type atomic orbitals at a nearly numerical multi-conflguration self-consistent field accuracy in a general non-orthogonal configuration interaction scheme. From these rates, we calculate the VUV photon emission and metastable atom spectra, and both are found to be in good qualitative agreement with recent excellent measurements. We obtain, successfully, the enhancement of the VUV photon spectrum, experimentally observed at the energy of （2s4p-4s2p）/（2p,3d） ^1po as compared with other nearby lying states. The mechanism proposed by Odling-Smee et al is verified, implying that taking appropriate account of the overlap existing between orbitals of the low-lying doubly excited and singly excited states （especially important for the compact orbitals） can reveal basic physical dominant mechanism and is crucial in understanding these spectra.展开更多
High quality LiLuF4 single crystals doped with various Pr3+ ions were synthesized by a vertical Bridgman method in completely sealed platinum crucibles. The excitation spectra spans from 420 nm to 500 nm. The prepared...High quality LiLuF4 single crystals doped with various Pr3+ ions were synthesized by a vertical Bridgman method in completely sealed platinum crucibles. The excitation spectra spans from 420 nm to 500 nm. The prepared single crystals exhibit a blue band at 480 nm(3P0→3H4), a green band at 522 nm (3P1→3H5), and a red band at 605 nm (1D2→3H4)when excited at 446 nm;their corresponding average lifetimes are 38.5μs, 37.3μs, and 36.8μs, respectively, which are much longer than those in oxide single crystals. The effects of excitation wavelength and doping concentration on emission intensities and chromaticity coordinates are investigated. The optimal Pr3+ concentration is confirmed to be 0.5%.The temperature dependent emission shows that the emission intensity constantly decreases with the increase of temperature from 298 K to 443 K due to the enhancement of nonradiative quenching at high temperature. The 3P0→3H4 transition is the most vulnerable to temperature, followed by the 3P1→3H5 transition and 1D2→3H4 transition.展开更多
The rigorous calculation of the spin-orbit terms in a three-quark system is realized based on the Gaussian expansion method and the infinitesimally-shifted Gaussian basis functions in the framework of the relativized ...The rigorous calculation of the spin-orbit terms in a three-quark system is realized based on the Gaussian expansion method and the infinitesimally-shifted Gaussian basis functions in the framework of the relativized quark model,by ignoring the mixing between different excited states.Then,the complete mass spectra of the singly heavy baryons are obtained rigorously,under the heavy-quark dominance mechanism.Accordingly,systematical analyses are performed for the reliability and predictive power of the model,the fine structure of the singly heavy baryon spectra,the assignments of the excited baryons,and some important topics about heavy baryon spectroscopy,such as the missing states,"spin-orbit puzzle,"and clustering effect.The results confirm that,under the heavy-quark dominance mechanism,the relativized quark model can describe the excitation spectra and the fine structures of the singly heavy baryons correctly and precisely.展开更多
The b-factories,such as BelleII,BarBar,and LHCb,emphasize the increasing importance of exotic hadron research.In this paper,we discuss the possible production of singly anti-charmed pentaquark states cqqqq from B meso...The b-factories,such as BelleII,BarBar,and LHCb,emphasize the increasing importance of exotic hadron research.In this paper,we discuss the possible production of singly anti-charmed pentaquark states cqqqq from B mesons in a b-factory under SU(3)symmetry analysis.Discussions of both possibilities have been driven by the hypothesis that the pentaquark state considered in this work,known as the lowest lying state P_(c),could be bound or unbound.We find the golden channels for the production of the pentaquark ground states,such as B^(0)→P_(csudu)^((′)0)Σ^(0).We further estimate the branching ratios for the production of the ground states P_(c) from B meson decays.Thus,multiple channels are available for experiments,which may remove certain obstacles to the discovery of new pentaquark states.展开更多
BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis th...BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.展开更多
Security and safety remain paramount concerns for both governments and individuals worldwide.In today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable...Security and safety remain paramount concerns for both governments and individuals worldwide.In today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable to society.Consequently,there is a pressing need for swift identification of potential threats to preemptively alert law enforcement and security forces,thereby preventing potential attacks or violent incidents.Recent advancements in big data analytics and deep learning have significantly enhanced the capabilities of computer vision in object detection,particularly in identifying firearms.This paper introduces a novel automatic firearm detection surveillance system,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the Single Shot Multibox Detector(SSD)model,which has been specifically optimized to balance the speed-accuracy trade-off critical in firearm detection applications.The SSD model was further refined by integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction capabilities.The experimental results demonstrate that this modified SSD configuration provides highly satisfactory performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy trade-off.Through these innovations,MARIE sets a new standard in surveillance technology,offering a robust solution to enhance public safety effectively.展开更多
Mid-infrared（MIR） emissions of 2.4 and 3.5 μm from Tm3＋：LiYF4 single crystals attributed to3H4 →3H5 and3H5 →3F4 transitions as well as MIR emissions of 4.2,4.3,and 4.5 μm from Nd3＋：LiYF4 lasers attributed to...Mid-infrared（MIR） emissions of 2.4 and 3.5 μm from Tm3＋：LiYF4 single crystals attributed to3H4 →3H5 and3H5 →3F4 transitions as well as MIR emissions of 4.2,4.3,and 4.5 μm from Nd3＋：LiYF4 lasers attributed to4I15/2 →4I13/2,4I13/2 →4I11/2,and4I11/2 →4I9/2 transitions,respectively,are observed.LiYF4 single crystals possess high transmittance of over 85% in the 2.5-6 μm range.The large emission crosssections of Tm-doped crystals at 2.4 μm（1.9×10-20cm2） and Nd-doped crystals at 4.2 μm（0.84×10-20 cm2） as well as the high rare-earth doping concentrations,excellent optical transmission,and chemicalphysical properties of the resultant samples indicate that Nd3＋and Tm3＋singly doped crystals may be promising materials for application in MIR lasers.展开更多
In contrast to research on active sites in nanomaterials,lithium tantalate single crystals,known for their exceptional optical properties and long-range ordered lattice structure,present a promising avenue for in-dept...In contrast to research on active sites in nanomaterials,lithium tantalate single crystals,known for their exceptional optical properties and long-range ordered lattice structure,present a promising avenue for in-depth exploration of photocatalytic reaction systems with fewer constraints imposed by surface chemistry.Typically,the isotropy of a specific facet provides a perfect support for studying heteroatom doping.Herein,this work delves into the intrinsic catalytic sites for photocatalytic nitrogen fixation in iron-doped lithium tantalate single crystals.The presence of iron not only modifies the electronic structure of lithium tantalate,improving its light absorption capacity,but also functions as an active site for the nitrogen adsorption and activation.The photocatalytic ammonia production rate of the iron-doped lithium tantalate in pure water is maximum 26.95μg cm^(−2)h^(−1),which is three times higher than that of undoped lithium tantalate.The combination of first-principles simulations with in situ characterizations confirms that iron doping promotes the rate-determining step and changes the pathway of hydrogenation to associative alternating.This study provides a new perspective on in-depth investigation of intrinsic catalytic active sites in photocatalysis and other catalytic processes.展开更多
Exploiting non-precious metal catalysts with excellent oxygen reduction reaction(ORR)performance for energy devices is paramount essential for the green and sustainable society development.Herein,low-cost,high-perform...Exploiting non-precious metal catalysts with excellent oxygen reduction reaction(ORR)performance for energy devices is paramount essential for the green and sustainable society development.Herein,low-cost,high-performance biomass-derived ORR catalysts with an asymmetric Fe-N_(3)P configuration was prepared by a simple pyrolysis-etching technique,where carboxymethyl cellulose(CMC)was used as the carbon source,urea and 1,10-phenanthroline iron complex(FePhen)as additives,and Na_(3)PO_(4)as the phosphorus dopant and a pore-forming agent.The CMC-derived FeNPC catalyst displayed a large specific area(BET:1235 m^(2)g^(-1))with atomically dispersed Fe-N_(3)P active sites,which exhibited superior ORR activity and stability in alkaline solution(E_(1/2)=0.90 V vs.RHE)and Zn-air batteries(P_(max)=149 mW cm^(-2))to commercial Pt/C catalyst(E_(1/2)=0.87 V,P_(max)=118 mW cm^(-2))under similar experimental conditions.This work provides a feasible and costeffective route toward highly efficient ORR catalysts and their application to Zn-air batteries for energy conversion.展开更多
The pursuit of alternative fuel generation technologies has gained momentum due to the diminishing reserves of fossil fuels and global warming from increased CO_(2)emission.Among the proposed methods,the hydrogenation...The pursuit of alternative fuel generation technologies has gained momentum due to the diminishing reserves of fossil fuels and global warming from increased CO_(2)emission.Among the proposed methods,the hydrogenation of CO_(2)to produce marketable carbon-based products like methanol and ethanol is a practical approach that offers great potential to reduce CO_(2)emissions.Although significant volumes of methanol are currently produced from CO_(2),developing highly efficient and stable catalysts is crucial for further enhancing conversion and selectivity,thereby reducing process costs.An in-depth examination of the differences and similarities in the reaction pathways for methanol and ethanol production highlights the key factors that drive C-C coupling.Identifying these factors guides us toward developing more effective catalysts for ethanol synthesis.In this paper,we explore how different catalysts,through the production of various intermediates,can initiate the synthesis of methanol or ethanol.The catalytic mechanisms proposed by spectroscopic techniques and theoretical calculations,including operando X-ray methods,FTIR analysis,and DFT calculations,are summarized and presented.The following discussion explores the structural properties and composition of catalysts that influence C-C coupling and optimize the conversion rate of CO_(2)into ethanol.Lastly,the review examines recent catalysts employed for selective methanol and ethanol production,focusing on single-atom catalysts.展开更多
Sulfide-based all-solid-state lithium batteries suffer from electrochemo-mechanical damage to Ni-rich oxide-based cathode active materials(CAMs),primarily caused by severe volume changes,results in significant stress ...Sulfide-based all-solid-state lithium batteries suffer from electrochemo-mechanical damage to Ni-rich oxide-based cathode active materials(CAMs),primarily caused by severe volume changes,results in significant stress and strain,causes micro-cracks and interfacial contact loss at potentials>4.3 V(vs.Li/Li^(+)).Quantifying micro-cracks and voids in CAMs can reveal the degradation mechanisms of Ni-rich oxidebased cathodes during electrochemical cycling.Nonetheless,the origin of electrochemical-mechanical damage remains unclear.Herein,We have developed a multifunctional PEG-based soft buffer layer(SBL)on the surface of carbon black(CB).This layer functions as a percolation network in the single crystal LiNi_(0.83)Co_(0.07)Mn_(0.1)O_(2)and Li_(6)PS_(5)Cl composite cathode layer,ensuring superior ionic conductivity,reducing void formation and particle cracking,and promoting uniform utilization of the cathode active material in all-solid-state lithium batteries(ASSLBs).High-angle annular dark-field STEM combined with nanoscale X-ray holo-tomography and plasma-focused ion beam scanning electron microscopy confirmed that the PEG-based SBL mitigated strain induced by reaction heterogeneity in the cathode.This strain produces lattice stretches,distortions,and curved transition metal oxide layers near the surface,contributing to structural degradation at elevated voltages.Consequently,ASSLBs with a LiNi_(0.83)Co_(0.07)Mn_(0.1)O_(2)cathode containing LCCB-10(CB/PEG mass ratio:100/10)demonstrate a high areal capacity(2.53 mAh g^(-1)/0.32 mA g^(-1))and remarkable rate capability(0.58 mAh g^(-1)at 1.4 mA g^(-1)),with88%capacity retention over 1000 cycles.展开更多
In recent years,train-tail swaying of 160 km/h electric multiple units(EMUs)inside single-line tunnels has been heavily researched,because the issue needs to be solved urgently.In this paper,a co-simulation model of v...In recent years,train-tail swaying of 160 km/h electric multiple units(EMUs)inside single-line tunnels has been heavily researched,because the issue needs to be solved urgently.In this paper,a co-simulation model of vortex-induced vibration(VIV)of the tail car body is established,and the aerodynamics of train-tail swaying is studied.The simulation results were confirmed through a field test of operating EMUs.Furthermore,the influence mechanism of train-tail swaying on the wake flow field is studied in detail through a wind-tunnel experiment and a simulation of a reduced-scaled train model.The results demonstrate that the aerodynamic force frequency(i.e.,vortex-induced frequency)of the train tail increases linearly with train speed.When the train runs at 130 km/h,with a small amplitude of train-tail swaying(within 10 mm),the vortex-induced frequency is 1.7 Hz,which primarily depends on the nose shape of the train tail.After the tail car body nose is extended,the vortex-induced frequency is decreased.As the swaying amplitude of the train tail increases(exceeding 25 mm),the separation point of the high-intensity vortex in the train wake shifts downstream to the nose tip,and the vortex-induced frequency shifts from 1.7 Hz to the nearby car body hunting(i.e.,the primary hunting)frequency of 1.3 Hz,which leads to the frequency-locking phenomenon of VIV,and the resonance intensifies train-tail swaying.For the motor vehicle of the train tail,optimization of the yaw damper to improve its primary hunting stability can effectively alleviate train-tail swaying inside single-line tunnels.Optimization of the tail car body nose shape reduces the amplitude of the vortex-induced force,thereby weakening the aerodynamic effect and solving the problem of train-tail swaying inside the single-line tunnels.展开更多
Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is k...Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.展开更多
Background:Platinum chemotherapy(CT)remains the backbone of systemic therapy for patients with smallcell lung cancer(SCLC).The nucleotide excision repair(NER)pathway plays a central role in the repair of the DNA damag...Background:Platinum chemotherapy(CT)remains the backbone of systemic therapy for patients with smallcell lung cancer(SCLC).The nucleotide excision repair(NER)pathway plays a central role in the repair of the DNA damage exerted by platinum agents.Alteration in this repair mechanism may affect patients’survival.Materials and Methods:We conducted a retrospective analysis of data from 38 patients with extensive disease(ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit,Careggi University Hospital,Florence(Italy),from 2015 to 2020.mRNA expression analysis and single nucleotide polymorphism(SNP)characterization of three NER pathway genes—namely ERCC1,ERCC2,and ERCC5—were performed on patient tumor samples.Results:Overall,elevated expression of ERCC genes was observed in SCLC patients compared to healthy controls.Patients with low ERCC1 and ERCC5 expression levels exhibited a better median progression-free survival(mPFS=7.1 vs.4.9 months,p=0.39 for ERCC1 and mPFS=6.9 vs.4.8 months,p=0.093 for ERCC5)and overall survival(mOS=8.7 vs.6.0 months,p=0.4 for ERCC1 and mOS=7.2 vs.6.2 months,p=0.13 for ERCC5).Genotyping analysis of five SNPs of ERCC genes showed a longer survival in patients harboring the wild-type genotype or the heterozygous variant of the ERCC1 rs11615 SNP(p=0.24 for PFS and p=0.14 for OS)and of the rs13181 and rs1799793 ERCC2 SNPs(p=0.43 and p=0.26 for PFS and p=0.21 and p=0.16 for OS,respectively)compared to patients with homozygous mutant genotypes.Conclusions:The comprehensive analysis of ERCC gene expression and SNP variants appears to identify patients who derive greater survival benefits from platinum-CT.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.1100429 and 51275519)
文摘The acoustic properties of anechoic layers with a singly periodic array of cylindrical scatterers are investigated. A method combined plane wave expansion and finite element analysis is extended for out-of-plane incidence. The reflection characteristics of the anechoic layers with cavities and locally resonant scatterers are discussed. The backing is a steel plate followed by an air half space. Under this approximate zero transmission backing condition, the reflection reduction is induced by the absorption enhancement. The absorption mechanism is explained by the scattering/absorption cross section of the isolated scatterer. Three types of resonant modes which can induce efficient absorption are revealed. Due to the fact that the frequencies of the resonant modes are related to the size of the scatterers, anechoic layers with scatterers of mixed size can broaden the absorption band. A genetic optimization algorithm is adopted to design the anechoic layer with scatterers of mixed size at a desired frequency band from 2 kHz to l0 kHz for normal incidence, and the influence of the incident angle is also discussed.
基金supported by the National Natural Science Foundation of China(Grant No.60878003)the Science Fund for Excellent Research Team of the National Natural Science Foundation of China(Grant No.60821004)the National Basic Research Program of China(Grant No.2010CB923101)
文摘We report a low noise continuous-wave （CW） single-frequency 1.5-μm laser source obtained by a singly resonant optical parametric oscillator （SRO） based on periodically poled lithium niobate （PPLN）. The SRO was pumped by a CW single-frequency Nd：YVO4 laser at 1.06μm. The 1.02 W of CW single-frequency signal laser at 1.5 μm was obtained at pump power of 6 W. At the output power of around 0.75 W, the power stability was better than ±l.5% and no mode-hopping was observed in 30 min and frequency stability was better than 8.5 MHz in 1 min. The signal wavelength could be tuned from 1.57 to 1.59 μm by varying the PPLN temperature. The 1.5-μm laser exhibits low noise characteristics, the intensity noise of the laser reaches the shot noise limit （SNL） at an analysis frequency of 4 MHz and the phase noise is less than 1 dB above the SNL at analysis frequencies above 10 MHz.
基金The NSF(11601020,11501014) of China2017 Commercial Specialty Project(19005757053) of BTBU2018 Postgraduate Research Capacity Improvement Project(19008001491) of BTBU
文摘Linked partitions were introduced by Dykema(Dykema K J. Multilinear function series and transforms in free probability theory. Adv. Math., 2005, 208(1):351–407) in the study of the unsymmetrized T-transform in free probability theory.Permutation is one of the most classical combinatorial structures. According to the linear representation of linked partitions, Chen et al.(Chen W Y C, Wu S Y J, Yan C H. Linked partitions and linked cycles. European J. Combin., 2008, 29(6): 1408–1426) de?ned the concept of singly covered minimal elements. Let L(n, k) denote the set of linked partitions of [n] with k singly covered minimal elements and let P(n, k) denote the set of permutations of [n] with k cycles. In this paper, we mainly establish two bijections between L(n, k) and P(n, k). The two bijections from a different perspective show the one-to-one correspondence between the singly covered minimal elements in L(n, k) and the cycles in P(n, k).
基金Supported by Science Research Project of Higher Schools of Guangxi(2015ZD019)Key Project of Guangxi University for Nationalities(2012MD033)
文摘Bi-f-harmonic maps are the critical points of bi-f-energy functional. This class of maps tends to integrate bi-harmonic maps and f-harmonic maps. In this paper, we show that bi-f-harmonic maps are not only an extension of f-harmonic maps but also an extension of bi-harmonic maps, and that there should exist many examples of proper bi-f-harmonic maps. In order to find some concrete examples of proper bi-f-harmonic maps, we study the basic properties of bi-f-harmonic maps from two directions which are conformal maps between the same dimensionM manifolds and some special maps from or into a warped product manifold.
基金supported by the National Basic Research Program of China (Grant No. 2010CB923101)the National Natural Science Foundation of China (Grant Nos. 61227015 and 61121064)
文摘We report on the generation of self-oscillations from a continuously pumped singly resonant frequency doubler based on a periodically poled potassium titanyl phosphate crystal （PPKTP）. The sustained square-wave and staircase curve of self-oscillations are obtained when the incident pump powers are below and above the threshold of subharmonic-pumped parametric oscillation （SPO）, respectively. The self-oscillations can be explained by the competition between the phase shifts induced by cascading nonlinearity and thermal effect, and the influence of fundamental nonlinear phase shift by the generation of SPO. The simulation results are in good agreement with the experiment data.
基金Project supported by the National Natural Science Foundation of China (20971042 and 50772035)the Science and Technology Office of Educa-tion Department of Hunan Province (10A070)the Science and Technology Bureau of Changsha City Government (K0902014-11)
文摘The establishment of an approach to design tunable yellow emission through singly doped single-phased phosphors to obtain white LED-based InGaN chip was reported. BaY2–xS4：xHo3＋ phosphors were prepared by the high temperature solid state reaction and characterized by X-ray diffraction and photoluminescence spectra. Under the excitation of 465 nm,the emission spectra of these phosphors exhibited three sharp emission lines peaked at about 492,543 and 661 nm of Ho3＋ corresponding to 5F3,5F4 （5S2） and 5F5→5I8 transitions,respectively,with comparable intensities,resulting in a yellow light emission. The luminescence mechanism for Ho3＋ in BaY2S4 was explained.
基金Project supported by the National Natural Science Foundation of China （Grant No 10347126）, National High Technology Development Program of China （Grant No 2004AA306H10） and the Program ＂Excellence in the Research Institutes Supervised by the General Secretariat for Research and Technology / Ministry of Development＂, Greece.Acknowledgments Xiong Zhuang would like to express his appreciation for the partial support from the Greek State Scholarship Foundation （I.K.Y.） and the National Hellenic Research Foundation Scholarship for this work.
文摘By taking full account of the non-orthogonality of the orbitals between the low-lying doubly excited states ^1po and the singly excited states ^1S^e and ^1D^e of He, the corresponding radiative decay rates have been investigated theoretically via analytic generalized Laguerre-type atomic orbitals at a nearly numerical multi-conflguration self-consistent field accuracy in a general non-orthogonal configuration interaction scheme. From these rates, we calculate the VUV photon emission and metastable atom spectra, and both are found to be in good qualitative agreement with recent excellent measurements. We obtain, successfully, the enhancement of the VUV photon spectrum, experimentally observed at the energy of （2s4p-4s2p）/（2p,3d） ^1po as compared with other nearby lying states. The mechanism proposed by Odling-Smee et al is verified, implying that taking appropriate account of the overlap existing between orbitals of the low-lying doubly excited and singly excited states （especially important for the compact orbitals） can reveal basic physical dominant mechanism and is crucial in understanding these spectra.
基金supported by the National Natural Science Foundation of China(No.51772159)the Natural Science Foundation of Zhejiang Province(No.LZ17E020001)K.C.Wong Magna Fund in Ningbo University
文摘High quality LiLuF4 single crystals doped with various Pr3+ ions were synthesized by a vertical Bridgman method in completely sealed platinum crucibles. The excitation spectra spans from 420 nm to 500 nm. The prepared single crystals exhibit a blue band at 480 nm(3P0→3H4), a green band at 522 nm (3P1→3H5), and a red band at 605 nm (1D2→3H4)when excited at 446 nm;their corresponding average lifetimes are 38.5μs, 37.3μs, and 36.8μs, respectively, which are much longer than those in oxide single crystals. The effects of excitation wavelength and doping concentration on emission intensities and chromaticity coordinates are investigated. The optimal Pr3+ concentration is confirmed to be 0.5%.The temperature dependent emission shows that the emission intensity constantly decreases with the increase of temperature from 298 K to 443 K due to the enhancement of nonradiative quenching at high temperature. The 3P0→3H4 transition is the most vulnerable to temperature, followed by the 3P1→3H5 transition and 1D2→3H4 transition.
基金Supported by the Open Project of Guangxi Key Lab of Nuclear Physics and Technology(NLK2023-04)the Central Government Guidance Funds for Local Scientific and Technological Development in China(Guike ZY22096024)+3 种基金the Natural Science Foundation of Guizhou Province-ZK[2024](General Project)650the National Natural Science Foundation of China(11675265,12175068)the Continuous Basic Scientific Research Project(WDJC-2019-13)the Leading Innovation Project(LC 192209000701)。
文摘The rigorous calculation of the spin-orbit terms in a three-quark system is realized based on the Gaussian expansion method and the infinitesimally-shifted Gaussian basis functions in the framework of the relativized quark model,by ignoring the mixing between different excited states.Then,the complete mass spectra of the singly heavy baryons are obtained rigorously,under the heavy-quark dominance mechanism.Accordingly,systematical analyses are performed for the reliability and predictive power of the model,the fine structure of the singly heavy baryon spectra,the assignments of the excited baryons,and some important topics about heavy baryon spectroscopy,such as the missing states,"spin-orbit puzzle,"and clustering effect.The results confirm that,under the heavy-quark dominance mechanism,the relativized quark model can describe the excitation spectra and the fine structures of the singly heavy baryons correctly and precisely.
基金Supported in part by the Youth Foundation of China University of Mining and Technology(JN210003)。
文摘The b-factories,such as BelleII,BarBar,and LHCb,emphasize the increasing importance of exotic hadron research.In this paper,we discuss the possible production of singly anti-charmed pentaquark states cqqqq from B mesons in a b-factory under SU(3)symmetry analysis.Discussions of both possibilities have been driven by the hypothesis that the pentaquark state considered in this work,known as the lowest lying state P_(c),could be bound or unbound.We find the golden channels for the production of the pentaquark ground states,such as B^(0)→P_(csudu)^((′)0)Σ^(0).We further estimate the branching ratios for the production of the ground states P_(c) from B meson decays.Thus,multiple channels are available for experiments,which may remove certain obstacles to the discovery of new pentaquark states.
基金Supported by The National Natural Science Foundation of China,No.82350127 and No.82241013the Shanghai Natural Science Foundation,No.20ZR1411600+2 种基金the Shanghai Shenkang Hospital Development Center,No.SHDC2020CR4039the Bethune Ethicon Excellent Surgery Foundation,No.CESS2021TC04Xuhui District Medical Research Project of Shanghai,No.SHXH201805.
文摘BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.
文摘Security and safety remain paramount concerns for both governments and individuals worldwide.In today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable to society.Consequently,there is a pressing need for swift identification of potential threats to preemptively alert law enforcement and security forces,thereby preventing potential attacks or violent incidents.Recent advancements in big data analytics and deep learning have significantly enhanced the capabilities of computer vision in object detection,particularly in identifying firearms.This paper introduces a novel automatic firearm detection surveillance system,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the Single Shot Multibox Detector(SSD)model,which has been specifically optimized to balance the speed-accuracy trade-off critical in firearm detection applications.The SSD model was further refined by integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction capabilities.The experimental results demonstrate that this modified SSD configuration provides highly satisfactory performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy trade-off.Through these innovations,MARIE sets a new standard in surveillance technology,offering a robust solution to enhance public safety effectively.
基金supported by the National Natural Science Foundation of China(Nos.51272109 and 50972061)the Natural Science Foundation of Zhejiang Province(No.R4100364)+1 种基金the Natural Science Foundation of Ningbo City(No.2012A610115)the K.C.Wong Magna Fund in Ningbo University
文摘Mid-infrared（MIR） emissions of 2.4 and 3.5 μm from Tm3＋：LiYF4 single crystals attributed to3H4 →3H5 and3H5 →3F4 transitions as well as MIR emissions of 4.2,4.3,and 4.5 μm from Nd3＋：LiYF4 lasers attributed to4I15/2 →4I13/2,4I13/2 →4I11/2,and4I11/2 →4I9/2 transitions,respectively,are observed.LiYF4 single crystals possess high transmittance of over 85% in the 2.5-6 μm range.The large emission crosssections of Tm-doped crystals at 2.4 μm（1.9×10-20cm2） and Nd-doped crystals at 4.2 μm（0.84×10-20 cm2） as well as the high rare-earth doping concentrations,excellent optical transmission,and chemicalphysical properties of the resultant samples indicate that Nd3＋and Tm3＋singly doped crystals may be promising materials for application in MIR lasers.
基金supported by Natural Science Foundation of Shandong Province(Nos.ZR2022YQ42,ZR2021JQ15,ZR2021QE011,ZR2021ZD20,2022GJJLJRC-01)Innovative Team Project of Jinan(No.2021GXRC019)the National Natural Science Foundation of China(Nos.52022037,52202366).
文摘In contrast to research on active sites in nanomaterials,lithium tantalate single crystals,known for their exceptional optical properties and long-range ordered lattice structure,present a promising avenue for in-depth exploration of photocatalytic reaction systems with fewer constraints imposed by surface chemistry.Typically,the isotropy of a specific facet provides a perfect support for studying heteroatom doping.Herein,this work delves into the intrinsic catalytic sites for photocatalytic nitrogen fixation in iron-doped lithium tantalate single crystals.The presence of iron not only modifies the electronic structure of lithium tantalate,improving its light absorption capacity,but also functions as an active site for the nitrogen adsorption and activation.The photocatalytic ammonia production rate of the iron-doped lithium tantalate in pure water is maximum 26.95μg cm^(−2)h^(−1),which is three times higher than that of undoped lithium tantalate.The combination of first-principles simulations with in situ characterizations confirms that iron doping promotes the rate-determining step and changes the pathway of hydrogenation to associative alternating.This study provides a new perspective on in-depth investigation of intrinsic catalytic active sites in photocatalysis and other catalytic processes.
基金supported by the National Natural Science Foundation of China(No.21571062)the Program for Professor of Special Appointment(Eastern Scholar)at the Shanghai Institutions of Higher Learning to JGL,and the Fundamental Research Funds for the Central Universities(No.222201717003)。
文摘Exploiting non-precious metal catalysts with excellent oxygen reduction reaction(ORR)performance for energy devices is paramount essential for the green and sustainable society development.Herein,low-cost,high-performance biomass-derived ORR catalysts with an asymmetric Fe-N_(3)P configuration was prepared by a simple pyrolysis-etching technique,where carboxymethyl cellulose(CMC)was used as the carbon source,urea and 1,10-phenanthroline iron complex(FePhen)as additives,and Na_(3)PO_(4)as the phosphorus dopant and a pore-forming agent.The CMC-derived FeNPC catalyst displayed a large specific area(BET:1235 m^(2)g^(-1))with atomically dispersed Fe-N_(3)P active sites,which exhibited superior ORR activity and stability in alkaline solution(E_(1/2)=0.90 V vs.RHE)and Zn-air batteries(P_(max)=149 mW cm^(-2))to commercial Pt/C catalyst(E_(1/2)=0.87 V,P_(max)=118 mW cm^(-2))under similar experimental conditions.This work provides a feasible and costeffective route toward highly efficient ORR catalysts and their application to Zn-air batteries for energy conversion.
基金the Canadian NRCan OERD Energy Innovation Programthe Natural Sciences and Engineering Research Council of Canada,and the Carbon Solution Program for their financial support.
文摘The pursuit of alternative fuel generation technologies has gained momentum due to the diminishing reserves of fossil fuels and global warming from increased CO_(2)emission.Among the proposed methods,the hydrogenation of CO_(2)to produce marketable carbon-based products like methanol and ethanol is a practical approach that offers great potential to reduce CO_(2)emissions.Although significant volumes of methanol are currently produced from CO_(2),developing highly efficient and stable catalysts is crucial for further enhancing conversion and selectivity,thereby reducing process costs.An in-depth examination of the differences and similarities in the reaction pathways for methanol and ethanol production highlights the key factors that drive C-C coupling.Identifying these factors guides us toward developing more effective catalysts for ethanol synthesis.In this paper,we explore how different catalysts,through the production of various intermediates,can initiate the synthesis of methanol or ethanol.The catalytic mechanisms proposed by spectroscopic techniques and theoretical calculations,including operando X-ray methods,FTIR analysis,and DFT calculations,are summarized and presented.The following discussion explores the structural properties and composition of catalysts that influence C-C coupling and optimize the conversion rate of CO_(2)into ethanol.Lastly,the review examines recent catalysts employed for selective methanol and ethanol production,focusing on single-atom catalysts.
基金supported by the Hainan Province Science and Technology Special Fund(ZDYF2021SHFZ232,ZDYF2023GXJS022)the Hainan Province Postdoctoral Science Foundation(300333)the National Natural Science Foundation of China(21203008,21975025,12274025,22372008)。
文摘Sulfide-based all-solid-state lithium batteries suffer from electrochemo-mechanical damage to Ni-rich oxide-based cathode active materials(CAMs),primarily caused by severe volume changes,results in significant stress and strain,causes micro-cracks and interfacial contact loss at potentials>4.3 V(vs.Li/Li^(+)).Quantifying micro-cracks and voids in CAMs can reveal the degradation mechanisms of Ni-rich oxidebased cathodes during electrochemical cycling.Nonetheless,the origin of electrochemical-mechanical damage remains unclear.Herein,We have developed a multifunctional PEG-based soft buffer layer(SBL)on the surface of carbon black(CB).This layer functions as a percolation network in the single crystal LiNi_(0.83)Co_(0.07)Mn_(0.1)O_(2)and Li_(6)PS_(5)Cl composite cathode layer,ensuring superior ionic conductivity,reducing void formation and particle cracking,and promoting uniform utilization of the cathode active material in all-solid-state lithium batteries(ASSLBs).High-angle annular dark-field STEM combined with nanoscale X-ray holo-tomography and plasma-focused ion beam scanning electron microscopy confirmed that the PEG-based SBL mitigated strain induced by reaction heterogeneity in the cathode.This strain produces lattice stretches,distortions,and curved transition metal oxide layers near the surface,contributing to structural degradation at elevated voltages.Consequently,ASSLBs with a LiNi_(0.83)Co_(0.07)Mn_(0.1)O_(2)cathode containing LCCB-10(CB/PEG mass ratio:100/10)demonstrate a high areal capacity(2.53 mAh g^(-1)/0.32 mA g^(-1))and remarkable rate capability(0.58 mAh g^(-1)at 1.4 mA g^(-1)),with88%capacity retention over 1000 cycles.
基金supported by the National Natural Science Foundation of China(Nos.52372403 and U2268211)the Natural Science Foundation of Sichuan Province(No.2022NSFSC0034),China+1 种基金the National Railway Group Science and Technology Program(No.2023J071)the Traction Power State Key Laboratory of the Independent Research and Development Projects(No.2022TPL-T02),China.
文摘In recent years,train-tail swaying of 160 km/h electric multiple units(EMUs)inside single-line tunnels has been heavily researched,because the issue needs to be solved urgently.In this paper,a co-simulation model of vortex-induced vibration(VIV)of the tail car body is established,and the aerodynamics of train-tail swaying is studied.The simulation results were confirmed through a field test of operating EMUs.Furthermore,the influence mechanism of train-tail swaying on the wake flow field is studied in detail through a wind-tunnel experiment and a simulation of a reduced-scaled train model.The results demonstrate that the aerodynamic force frequency(i.e.,vortex-induced frequency)of the train tail increases linearly with train speed.When the train runs at 130 km/h,with a small amplitude of train-tail swaying(within 10 mm),the vortex-induced frequency is 1.7 Hz,which primarily depends on the nose shape of the train tail.After the tail car body nose is extended,the vortex-induced frequency is decreased.As the swaying amplitude of the train tail increases(exceeding 25 mm),the separation point of the high-intensity vortex in the train wake shifts downstream to the nose tip,and the vortex-induced frequency shifts from 1.7 Hz to the nearby car body hunting(i.e.,the primary hunting)frequency of 1.3 Hz,which leads to the frequency-locking phenomenon of VIV,and the resonance intensifies train-tail swaying.For the motor vehicle of the train tail,optimization of the yaw damper to improve its primary hunting stability can effectively alleviate train-tail swaying inside single-line tunnels.Optimization of the tail car body nose shape reduces the amplitude of the vortex-induced force,thereby weakening the aerodynamic effect and solving the problem of train-tail swaying inside the single-line tunnels.
基金supported by the National Key Research&Development Program of China,Nos.2021YFC2501205(to YC),2022YFC24069004(to JL)the STI2030-Major Project,Nos.2021ZD0201101(to YC),2022ZD0211800(to YH)+2 种基金the National Natural Science Foundation of China(Major International Joint Research Project),No.82020108013(to YH)the Sino-German Center for Research Promotion,No.M-0759(to YH)a grant from Beijing Municipal Science&Technology Commission(Beijing Brain Initiative),No.Z201100005520018(to JL)。
文摘Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.
文摘Background:Platinum chemotherapy(CT)remains the backbone of systemic therapy for patients with smallcell lung cancer(SCLC).The nucleotide excision repair(NER)pathway plays a central role in the repair of the DNA damage exerted by platinum agents.Alteration in this repair mechanism may affect patients’survival.Materials and Methods:We conducted a retrospective analysis of data from 38 patients with extensive disease(ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit,Careggi University Hospital,Florence(Italy),from 2015 to 2020.mRNA expression analysis and single nucleotide polymorphism(SNP)characterization of three NER pathway genes—namely ERCC1,ERCC2,and ERCC5—were performed on patient tumor samples.Results:Overall,elevated expression of ERCC genes was observed in SCLC patients compared to healthy controls.Patients with low ERCC1 and ERCC5 expression levels exhibited a better median progression-free survival(mPFS=7.1 vs.4.9 months,p=0.39 for ERCC1 and mPFS=6.9 vs.4.8 months,p=0.093 for ERCC5)and overall survival(mOS=8.7 vs.6.0 months,p=0.4 for ERCC1 and mOS=7.2 vs.6.2 months,p=0.13 for ERCC5).Genotyping analysis of five SNPs of ERCC genes showed a longer survival in patients harboring the wild-type genotype or the heterozygous variant of the ERCC1 rs11615 SNP(p=0.24 for PFS and p=0.14 for OS)and of the rs13181 and rs1799793 ERCC2 SNPs(p=0.43 and p=0.26 for PFS and p=0.21 and p=0.16 for OS,respectively)compared to patients with homozygous mutant genotypes.Conclusions:The comprehensive analysis of ERCC gene expression and SNP variants appears to identify patients who derive greater survival benefits from platinum-CT.
