Chronic migraine(CM)is a prevalent and highly debilitating neurological disorder.Functional magnetic resonance imaging(fMRI)studies have demonstrated associations between abnormal brain region activation and CM,yet th...Chronic migraine(CM)is a prevalent and highly debilitating neurological disorder.Functional magnetic resonance imaging(fMRI)studies have demonstrated associations between abnormal brain region activation and CM,yet the underlying complex neural circuitry mechanisms remain unclear.The spinal trigeminal nucleus caudalis(Sp5C)serves as the primary central hub for orofacial nociceptive input,receiving trigeminal pain signals and projecting to higher-order centers such as the thalamus.Therefore,we sought to investigate whether the Sp5C region and its associated circuits were involved in CM pathogenesis.In this study,we established a CM mouse model through repeated intraperitoneal injections of nitroglycerin(NTG).Using a combination of in vivo fiber photometry and in vitro c-Fos immunohistochemistry,we found a marked periorbital and plantar mechanical allodynia in CM mice,accompanied by increased glutamatergic neuronal activity in Sp5C.Chemogenetic manipulation of Sp5C glutamatergic neurons(Sp5CV^(glut2))bidirectionally modulated migraine-like behaviors and induced pain-related affective states,as evidenced by conditioned place preference/aversion(CPP/CPA)paradigms.Anterograde viral tracing revealed dense projections from Sp5C^(Vglut2)to the subthalamic nucleus(STN),which was activated in CM mice.Optogenetic activation of the Sp5C-STN pathway similarly produced migraine-like behaviors and pain-related aversive memory in mice.Altogether,we revealed a critical role of the Sp5CVglut2-STN circuit in the development and modulation of CM.Our findings provide novel mechanistic insights into the central mechanisms underlying CM,establishing potential theoretical foundations for clinical diagnosis and therapeutic development.展开更多
Herein,a simple and effective outer-surface interactions assisted supramolecular hierarchical assembly has been first exploited to uniformly distribute tungstosilicic acid(TSA)inside the porous structure of cucurbit[1...Herein,a simple and effective outer-surface interactions assisted supramolecular hierarchical assembly has been first exploited to uniformly distribute tungstosilicic acid(TSA)inside the porous structure of cucurbit[10]uril-based single-layer 2D supramolecular-organic-frameworks(Q[10]-SOFs)in water.Importantly,the 2D Q[10]-SOFs can further serve as light harvesting antenna,achieving fast energy transfer to the embedded redox-active TSA upon photoexcitation,resulting in efficient visible light-driven selective oxidation of benzyl alcohols into the corresponding aldehydes in high yield at room temperature.Further studies revealed that the integrated of 2D Q[10]-SOFs and TSA played a key role in the catalytic process,due to the presence of a novel stepwise electron transfer route in the single-layer hybrid 2D structures.展开更多
After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the tim...After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.展开更多
Replicating the chaotic characteristics inherent in nonlinear dynamical systems via machine learning(ML)is a key challenge in this rapidly advancing interdisciplinary field.In this work,we explore the potential of var...Replicating the chaotic characteristics inherent in nonlinear dynamical systems via machine learning(ML)is a key challenge in this rapidly advancing interdisciplinary field.In this work,we explore the potential of variational quantum circuits(VQC)for learning the stochastic properties of classical nonlinear dynamical systems.Specifically,we focus on the one-and two-dimensional logistic maps,which,while simple,remain under-explored in the context of learning dynamical characteristics.Our findings reveal that,even for such simple dynamical systems,accurately replicating longterm characteristics is hindered by a pronounced sensitivity to overfitting.While increasing the parameter complexity of the ML model typically enhances short-term prediction accuracy,it also leads to a degradation in the model’s ability to replicate long-term characteristics,primarily due to the detrimental effects of overfitting on generalization power.By comparing the VQC with two widely recognized classical ML techniques,which are long short-term memory(LSTM)networks for timeseries processing and reservoir computing,we demonstrate that VQC outperforms these methods in terms of replicating long-term characteristics.Our results suggest that for the ML of dynamics,it is demanded to develop more compact and efficient models(such as VQC)rather than more complicated and large-scale ones.展开更多
The output voltages for the capacitive elements of a neural circuit model can be mapped into dimensionless capacitive variables,which present firing patterns similar to the membrane potentials detected in biological n...The output voltages for the capacitive elements of a neural circuit model can be mapped into dimensionless capacitive variables,which present firing patterns similar to the membrane potentials detected in biological neurons.The inclusion of a memcapacitor also en‐ables consideration of membrane deformation effects,enhancing the model’s capacity to simulate neuronal behavior across varying physio‐logical and environmental conditions.In this study,a capacitor and a memcapacitor are connected through a linear resistor in parallel with other electric components in different branch circuits composed of an inductor and a nonlinear resistor.The electrical activities in a neuron with a double-layer membrane and two capacitive variables are discussed in detail after converting the nonlinear equations for the neural circuit into a theoretical neuron model.A dimensionless neuron model and its corresponding energy function are derived.The field energy function for the neural circuit is converted into an equivalent Hamilton energy function and further validated via the Helmholtz theorem.Furthermore,the average value of energy serves as an indicator for predicting stochastic resonance,as supported by analyzing the distribu‐tion of the coefficient of variation.The neuronal firing patterns are shown to be energy-dependent.An adaptive control strategy is proposed to regulate mode transitions in electrical activities of the neuron.An analog equivalent circuit is constructed to experimentally verify the nu‐merical results,thereby supporting the reliability of the proposed neuron model.展开更多
Point-of-care diagnostics and inline quantitative phase imaging(QPI)drive the demand for portable,ultra-miniaturized,and robust optical imaging and metrology systems.We propose and demonstrate a wavefront sensor integ...Point-of-care diagnostics and inline quantitative phase imaging(QPI)drive the demand for portable,ultra-miniaturized,and robust optical imaging and metrology systems.We propose and demonstrate a wavefront sensor integrated into a photonic integrated circuit,enabling single-shot optical phase retrieval.We implemented an integrated wavefront sensor array with a spatial resolution of 17μm and a numerical aperture of 0.1.Furthermore,we experimentally demonstrated the reconstruction of wavefronts defined by Zernike polynomials,specifically the first 14 terms(Z_(1)to Z_(14)),achieving an average root mean square error below 0.07.This advancement paves the way for fully integrated,portable,and robust optical imaging systems,facilitating integrated wavefront sensors in demanding applications such as point-of-care diagnostics,endoscopy,in situ QPI,and inline surface profile measurement.展开更多
Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at th...Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at the molecular,cellular,and neural circuit levels.Abnormal molecular signaling pathways or dysfunction of specific cell types can lead to epilepsy by disrupting the normal functioning of neural circuits.The continuous emergence of new technologies and the rapid advancement of existing ones have facilitated the discovery and comprehensive understanding of the neural circuit mechanisms underlying epilepsy.Therefore,this review aims to investigate the current understanding of the neural circuit mechanisms in epilepsy based on various technologies,including electroencephalography,magnetic resonance imaging,optogenetics,chemogenetics,deep brain stimulation,and brain-computer interfaces.Additionally,this review discusses these mechanisms from three perspectives:structural,synaptic,and transmitter circuits.The findings reveal that the neural circuit mechanisms of epilepsy encompass information transmission among different structures,interactions within the same structure,and the maintenance of homeostasis at the cellular,synaptic,and neurotransmitter levels.These findings offer new insights for investigating the pathophysiological mechanisms of epilepsy and enhancing its clinical diagnosis and treatment.展开更多
Given the wide application of DC grids,the protection equipment of power grids must be improved during the fault period.This study proposes an integrated multiport flexible voltage clamp circuit breaker with a DC chop...Given the wide application of DC grids,the protection equipment of power grids must be improved during the fault period.This study proposes an integrated multiport flexible voltage clamp circuit breaker with a DC chopper acting on the receiving end converter to solve the DC short circuit fault and surplus power because of AC low-voltage fault;it has a modular design.As a DC circuit breaker,the device utilizes the voltage-clamping principle and thyristor semi-control to remove faults.As the fault current increases,the branch circuit outputs different voltage levels by selecting different gears,thereby controlling the voltage-clamping effect.This device can distinguish between different fault types to prevent secondary shocks in the system.As a DC chopper,the voltage at both ends of the energy dissipation resistor is varied by switching submodules,consuming surplus power to complete AC low-voltage faults and minimizing the impact of low-voltage faults on the system’s transmission capacity.Finally,the effectiveness and applicability of the equipment are verified using wind turbines connected to a flexible DC transmission three-terminal power grid model in PSCAD/EMTDC,and two fault simulation types are analyzed.A comparison of the electrical quantities(fault current,system voltage and branch voltage)of the proposed circuit breaker with other similar equipment shows that due to the efficiency of the proposed equipment,the peak fault current is reduced by at least 35.8%.The required voltage stress of key power electronic equipment is reduced by at least 71.5%.Therefore,the equipment ensures that the per-unit voltage of the DC system does not exceed 1.05 during AC fault crossing.展开更多
Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after inju...Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.展开更多
To address the issues of high costs and low component utilization caused by the independent configuration of hybrid DC circuit breakers(HCBs)and DC power flow controllers(DCPFCs)at each port in existing DC distributio...To address the issues of high costs and low component utilization caused by the independent configuration of hybrid DC circuit breakers(HCBs)and DC power flow controllers(DCPFCs)at each port in existing DC distribution networks,this paper adopts a component sharing mechanism to propose a composite multi-port hybrid DC circuit breaker(CM-HCB)with DC power flow and fault current limitation abilities,as well as reduced component costs.The proposed CM-HCB topology enables the sharing of the main breaker branch(MB)and the energy dissipation branch,while the load commutation switches(LCSs)in the main branch are reused as power flow control components,enabling flexible regulation of power flow in multiple lines.Meanwhile,by reconstructing the current path during the fault process,the proposed CM-HCB can utilize the internal coupled inductor to limit the current rise rate at the initial stage of the fault,significantly reducing the requirement for breaking current.A detailed study on the topological structure,steady-state power flow regulation mechanism,transient fault isolation mechanism,control strategy and characteristic analysis of the proposed CM-HCB is presented.Then,a Matlab/Simulink-based meshed three-terminal DC grid simulation platform with the proposed CM-HCB is built.The results indicate that the proposed CM-HCB can not only achieve flexible power flow control during steady-state operation,but also obtain current rise limitation and fault isolation abilities under short-circuit fault conditions,verifying its correctness and effectiveness.Finally,a comparative economic analysis is conducted between the proposed CM-HCB and the other two existing solutions,confirming that its component sharing mechanism can significantly reduce the number of components,lower system costs,and improve component utilization.展开更多
The mammalian cerebral cortex,despite its variation in brain shape and size,is a stereotypical six-layered structure composed of pyramidal cells,interneurons,astrocytes,microglia,oligodendrocytes,and endothelial cells...The mammalian cerebral cortex,despite its variation in brain shape and size,is a stereotypical six-layered structure composed of pyramidal cells,interneurons,astrocytes,microglia,oligodendrocytes,and endothelial cells.During development,these cells differ in their origin,birth timing,and developmental trajectories.Nonetheless,they converge during development,forming nascent cortical circuits crucial for organismal behavior.While the relative proportions of cortical cells vary between regions.展开更多
The concept of the imperfection sensitive region is given. The advanced stochastic imperfection method is used to research the imperfection sensitive region of single-layer latticed domes. Taking a K6 single-layer lat...The concept of the imperfection sensitive region is given. The advanced stochastic imperfection method is used to research the imperfection sensitive region of single-layer latticed domes. Taking a K6 single-layer latticed dome with a diameter of 50 m as an example, its imperfection sensitive region is made up of the first 12 kinds of joints. The influence of the imperfections of support joints on the stability of the K6 single-layer latticed dome is negligible. Influences of the joint imperfections of the main rib and the secondary rib on the structural stability are similar. The initial deviations of these joints all greatly lower the critical load of the dome. Results show that the method can analyze the structural imperfection sensitive region quantitatively and accurately.展开更多
In order to develop the high-efficiency and precision machining technique of TiCp/Ti - 6Al-4V particulate reinforced titanium matrix composites （PTMCs）, high-speed grinding experiments were conducted using the singl...In order to develop the high-efficiency and precision machining technique of TiCp/Ti - 6Al-4V particulate reinforced titanium matrix composites （PTMCs）, high-speed grinding experiments were conducted using the single-layer electroplated cubic boron nitride （CBN） wheel and brazed CBN wheel, respectively. The comparative grinding performance was studied in terms of grinding force, grinding temperature, grinding-induced surface features and defects. The results display that the grinding forces and grinding temperature obtained with the brazed CBN wheel are always lower than those with the electroplated CBN wheel. Though the voids and microcracks are the dominant grinding-induced surface defects, the brazed CBN wheel produces less surface defects compared to the electroplated wheel according to the statistical analysis results. The max mum materials removal rate with the brazed CBN wheel is much higher than that with the electroplated one. All above indicate that the single-layer brazed CBN super-abrasive wheel is more suitable for high-speed grinding of PTMCs than the electroplated counterpart.展开更多
Single-layer superconductors are ideal materials for fabricating superconducting nano devices.However,up to date,very few single-layer elemental superconductors have been predicted and especially no one has been succe...Single-layer superconductors are ideal materials for fabricating superconducting nano devices.However,up to date,very few single-layer elemental superconductors have been predicted and especially no one has been successfully synthesized yet.Here,using crystal structure search techniques and ab initio calculations,we predict that a single-layer planar carbon sheet with 4-and 8-membered rings called T-graphene is a new intrinsic elemental superconductor with superconducting critical temperature(Tc)up to around 20.8 K.More importantly,we propose a synthesis route to obtain such a single-layer T-graphene,that is,a T-graphene potassium intercalation compound(C4 K with P4/mmm symmetry)is firstly synthesized at high pressure(>11.5 GPa)and then quenched to ambient condition;and finally,the single-layer T-graphene can be either exfoliated using the electrochemical method from the bulk C4 K,or peeled off from bulk T-graphite C4,where C4 can be obtained from C4 K by evaporating the K atoms.Interestingly,we find that the calculated Tc of C4 K is about 30.4 K at 0 GPa,which sets a new record for layered carbon-based superconductors.The present findings add a new class of carbon-based superconductors.In particular,once the single-layer T-graphene is synthesized,it can pave the way for fabricating superconducting devices together with other 2 D materials using the layer-by-layer growth techniques.展开更多
MXenes,a family of two-dimensional(2D)materials,exhibit peculiar microwave-absorbing behaviors due to their unique chemical composition and structure.Although laminated Ti_(3)C_(2)T_(x) MXenes with a multilayer struct...MXenes,a family of two-dimensional(2D)materials,exhibit peculiar microwave-absorbing behaviors due to their unique chemical composition and structure.Although laminated Ti_(3)C_(2)T_(x) MXenes with a multilayer structure have been used for microwave absorption,real 2D MXenes with a single-layer structure have not yet been investigated.Here,the electromagnetic wave response behavior of single-layer Ti_(3)C_(2)T_(x) MXenes was explored in detail.The permittivity of Ti_(3)C_(2)T_(x) MXene rises dramatically with an increase in filler loading,and Ti_(3)C_(2)T_(x) MXene features a distinct dielectric response wherein dipolar polarization and interfacial polarization makes a greater contribution at low filler loading;conductive loss becomes more prominent at high filler loading.Versus laminated Ti_(3)C_(2)T_(x) MXene,single-layer Ti_(3)C_(2)T_(x) MXene delivers superior absorbing capability:The RLminvalue of SL-Ti_(3)C_(2)T_(x)-22%reaches-43.5 d B at 6.5 GHz,and a broad EAB of 6.88 GHz can be attained at a thickness of 1.8 mm due to enhanced dipolar polarization,interfacial polarization,and conductive loss.This work is of great significance in guiding the future development of MXene-based absorbers.展开更多
The single-layer latticed cylindrical shell is one of the most widely adopted space-fl'amed structures.In this paper,free vibration properties and dynamic response to horizontal and vertical seismic waves of singl...The single-layer latticed cylindrical shell is one of the most widely adopted space-fl'amed structures.In this paper,free vibration properties and dynamic response to horizontal and vertical seismic waves of single-layer latticed cylindrical shells are analyzed by the finite element method using ANSYS software.In the numerical study,where hundreds of cases were analyzed,the parameters considered included rise-span ratio,length-span ratio,surface load and member section size.Moreover,to better define the actual behavior of single-layer latticed shells,the study is focused on the dynamic stress response to both axial forces and bending moments.Based on the numerical results,the effects of the parameters considered on the stresses are discussed and a modified seismic force coefficient method is suggested.In addition,some advice based on these research results is presented to help in the future design of such structures.展开更多
Based on vibration analysis, single-layered graphene sheet （SLGS） with multiple attached nanoparticles is developed as nanoscale mass sensor in thermal environments. Graphene sensors are assumed to be in simplysuppo...Based on vibration analysis, single-layered graphene sheet （SLGS） with multiple attached nanoparticles is developed as nanoscale mass sensor in thermal environments. Graphene sensors are assumed to be in simplysupported configuration. Based on the nonlocal plate the- ory which incorporates size effects into the classical theory, closed-form expressions lot the frequencies and relative fre- quency shills of SLGS-based mass sensor are derived using the Galerkin method. The suggested model is justified by a good agreement between the results given by the present model and available data in literature. The effects of tem- perature difference, nonlocal parameter, the location of the nanoparticle and the number of nanoparticles on the relative frequency shift of the mass sensor are also elucidated. The obtained results show that the sensitivity of the SLGS- based mass sensor increases with increasing temperature difference.展开更多
Circularly polarized （CP） lens antenna has been applied to numerous wireless communication systems based on its unique advantages such as high antenna gain, low manufacturing cost, especially stable data transmissio...Circularly polarized （CP） lens antenna has been applied to numerous wireless communication systems based on its unique advantages such as high antenna gain, low manufacturing cost, especially stable data transmission between the transmitter and the receiver. Unfortunately, current available CP lens antennas mostly suffer from high profile, low aperture efficiency as well as complex design. In this paper, we propose an ultra-thin CP lens antenna based on the designed single- layered Pancharatnam-Berry （PB） transparent metasurface with focusing property. The PB metasurface exhibits a high transmissivity, which ensures a high efficiency of the focusing property. Launched the metasurface with a CP patch antenna at its focal point, a low-profile lens antenna is simulated and measured. The experimental results show that our lens antenna exhibits a series of advantages including high radiation gain of 20.7 dB, aperture efficiency better than 41.3%, and also narrow half power beam width （HPBW） of 13°at about 14GHz. Our finding opens a door to realize ultra-thin transparent metasurface with other functionalities or at other working frequencies.展开更多
We report near-zero crossover for vanadium cross-permeation through single-layer graphene immobilized at the interface of two Nafion?polymer electrolyte membranes.Vanadium ion diffusion and migration,including proton ...We report near-zero crossover for vanadium cross-permeation through single-layer graphene immobilized at the interface of two Nafion?polymer electrolyte membranes.Vanadium ion diffusion and migration,including proton mobility through membrane composites,were studied with and without graphene under diffusion and migration conditions.Single-layer graphene was found to effectively inhibit vanadium ion diffusion and migration under specific conditions.The single-layer graphene composites also enabled remarkable ion transmission selectivity improvements over pure Nafion membranes,with proton transport being four orders of magnitude faster than vanadium ion transport.Resistivity values of 0.02±0.005Ωcm^(2) for proton and 223±4Ωcm^(2) for vanadium ion through single atomic layer graphene are reported.This high selectivity may have significant impact on flow battery applications or for other electrochemical devices where proton conductivity is required,and transport of other species is detrimental.Our results emphasize that crossover may be essentially completely eliminated in some cases,enabling for greatly improved operational viability.展开更多
To study the damage mechanism of single-layer reticulated domes subject to severe earthquakes, three limit states of single-layer reticulated domes under earthquakes are defined firstly in this paper. Then, two failur...To study the damage mechanism of single-layer reticulated domes subject to severe earthquakes, three limit states of single-layer reticulated domes under earthquakes are defined firstly in this paper. Then, two failure modes are presented by analyzing damage behaviors, and their characteristics are pointed out respectively. Furthermore, the damage process is analyzed and the causes of structural damage in different levels are studied. Finally, by comparing deformation and vibration status of domes with different failure modes, the principles of different failures are revealed and an integrated frame of damage mechanism is set up.展开更多
基金supported by the National Natural Science Foundation of China(No.32571336 and 32271048)Research Funds of Centre for Leading Medicine and Advanced Technologies of IHM(No.2025IHM01100)。
文摘Chronic migraine(CM)is a prevalent and highly debilitating neurological disorder.Functional magnetic resonance imaging(fMRI)studies have demonstrated associations between abnormal brain region activation and CM,yet the underlying complex neural circuitry mechanisms remain unclear.The spinal trigeminal nucleus caudalis(Sp5C)serves as the primary central hub for orofacial nociceptive input,receiving trigeminal pain signals and projecting to higher-order centers such as the thalamus.Therefore,we sought to investigate whether the Sp5C region and its associated circuits were involved in CM pathogenesis.In this study,we established a CM mouse model through repeated intraperitoneal injections of nitroglycerin(NTG).Using a combination of in vivo fiber photometry and in vitro c-Fos immunohistochemistry,we found a marked periorbital and plantar mechanical allodynia in CM mice,accompanied by increased glutamatergic neuronal activity in Sp5C.Chemogenetic manipulation of Sp5C glutamatergic neurons(Sp5CV^(glut2))bidirectionally modulated migraine-like behaviors and induced pain-related affective states,as evidenced by conditioned place preference/aversion(CPP/CPA)paradigms.Anterograde viral tracing revealed dense projections from Sp5C^(Vglut2)to the subthalamic nucleus(STN),which was activated in CM mice.Optogenetic activation of the Sp5C-STN pathway similarly produced migraine-like behaviors and pain-related aversive memory in mice.Altogether,we revealed a critical role of the Sp5CVglut2-STN circuit in the development and modulation of CM.Our findings provide novel mechanistic insights into the central mechanisms underlying CM,establishing potential theoretical foundations for clinical diagnosis and therapeutic development.
基金supported by the National Natural Science Foundation of China(No.22271090)。
文摘Herein,a simple and effective outer-surface interactions assisted supramolecular hierarchical assembly has been first exploited to uniformly distribute tungstosilicic acid(TSA)inside the porous structure of cucurbit[10]uril-based single-layer 2D supramolecular-organic-frameworks(Q[10]-SOFs)in water.Importantly,the 2D Q[10]-SOFs can further serve as light harvesting antenna,achieving fast energy transfer to the embedded redox-active TSA upon photoexcitation,resulting in efficient visible light-driven selective oxidation of benzyl alcohols into the corresponding aldehydes in high yield at room temperature.Further studies revealed that the integrated of 2D Q[10]-SOFs and TSA played a key role in the catalytic process,due to the presence of a novel stepwise electron transfer route in the single-layer hybrid 2D structures.
基金supported by the National Key Research and Development Program of China,No.2023YFC3603705(to DX)the National Natural Science Foundation of China,No.82302866(to YZ).
文摘After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.
基金Project supported in part by Beijing Natural Science Foundation(Grant No.1232025)Peng Huanwu Visiting Pro-fessor Program,and Academy for Multidisciplinary Studies,Capital Normal University.
文摘Replicating the chaotic characteristics inherent in nonlinear dynamical systems via machine learning(ML)is a key challenge in this rapidly advancing interdisciplinary field.In this work,we explore the potential of variational quantum circuits(VQC)for learning the stochastic properties of classical nonlinear dynamical systems.Specifically,we focus on the one-and two-dimensional logistic maps,which,while simple,remain under-explored in the context of learning dynamical characteristics.Our findings reveal that,even for such simple dynamical systems,accurately replicating longterm characteristics is hindered by a pronounced sensitivity to overfitting.While increasing the parameter complexity of the ML model typically enhances short-term prediction accuracy,it also leads to a degradation in the model’s ability to replicate long-term characteristics,primarily due to the detrimental effects of overfitting on generalization power.By comparing the VQC with two widely recognized classical ML techniques,which are long short-term memory(LSTM)networks for timeseries processing and reservoir computing,we demonstrate that VQC outperforms these methods in terms of replicating long-term characteristics.Our results suggest that for the ML of dynamics,it is demanded to develop more compact and efficient models(such as VQC)rather than more complicated and large-scale ones.
基金supported by the National Natural Science Foundation of China(No.12072139).
文摘The output voltages for the capacitive elements of a neural circuit model can be mapped into dimensionless capacitive variables,which present firing patterns similar to the membrane potentials detected in biological neurons.The inclusion of a memcapacitor also en‐ables consideration of membrane deformation effects,enhancing the model’s capacity to simulate neuronal behavior across varying physio‐logical and environmental conditions.In this study,a capacitor and a memcapacitor are connected through a linear resistor in parallel with other electric components in different branch circuits composed of an inductor and a nonlinear resistor.The electrical activities in a neuron with a double-layer membrane and two capacitive variables are discussed in detail after converting the nonlinear equations for the neural circuit into a theoretical neuron model.A dimensionless neuron model and its corresponding energy function are derived.The field energy function for the neural circuit is converted into an equivalent Hamilton energy function and further validated via the Helmholtz theorem.Furthermore,the average value of energy serves as an indicator for predicting stochastic resonance,as supported by analyzing the distribu‐tion of the coefficient of variation.The neuronal firing patterns are shown to be energy-dependent.An adaptive control strategy is proposed to regulate mode transitions in electrical activities of the neuron.An analog equivalent circuit is constructed to experimentally verify the nu‐merical results,thereby supporting the reliability of the proposed neuron model.
基金supported by the National Natural Science Foundation of China(Grant Nos.52175509 and 52450158)the National Key Research and Development Program of China(Grant No.2023YFF1500900)+2 种基金the Shenzhen Fundamental Research Program(Grant No.JCYJ20220818100412027)the Guangdong-Hong Kong Technology Cooperation Funding Scheme Category C Platform(Grant No.SGDX20230116093543005)the Innovation Project of Optics Valley Laboratory(Grant No.OVL2023PY003)。
文摘Point-of-care diagnostics and inline quantitative phase imaging(QPI)drive the demand for portable,ultra-miniaturized,and robust optical imaging and metrology systems.We propose and demonstrate a wavefront sensor integrated into a photonic integrated circuit,enabling single-shot optical phase retrieval.We implemented an integrated wavefront sensor array with a spatial resolution of 17μm and a numerical aperture of 0.1.Furthermore,we experimentally demonstrated the reconstruction of wavefronts defined by Zernike polynomials,specifically the first 14 terms(Z_(1)to Z_(14)),achieving an average root mean square error below 0.07.This advancement paves the way for fully integrated,portable,and robust optical imaging systems,facilitating integrated wavefront sensors in demanding applications such as point-of-care diagnostics,endoscopy,in situ QPI,and inline surface profile measurement.
基金supported by Basic Research Programs of Science and Technology Commission Foundation of Shanxi Province,No.20210302123486(to WJ).
文摘Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at the molecular,cellular,and neural circuit levels.Abnormal molecular signaling pathways or dysfunction of specific cell types can lead to epilepsy by disrupting the normal functioning of neural circuits.The continuous emergence of new technologies and the rapid advancement of existing ones have facilitated the discovery and comprehensive understanding of the neural circuit mechanisms underlying epilepsy.Therefore,this review aims to investigate the current understanding of the neural circuit mechanisms in epilepsy based on various technologies,including electroencephalography,magnetic resonance imaging,optogenetics,chemogenetics,deep brain stimulation,and brain-computer interfaces.Additionally,this review discusses these mechanisms from three perspectives:structural,synaptic,and transmitter circuits.The findings reveal that the neural circuit mechanisms of epilepsy encompass information transmission among different structures,interactions within the same structure,and the maintenance of homeostasis at the cellular,synaptic,and neurotransmitter levels.These findings offer new insights for investigating the pathophysiological mechanisms of epilepsy and enhancing its clinical diagnosis and treatment.
基金supported by National Natural Science Foundation of China(U2066208).
文摘Given the wide application of DC grids,the protection equipment of power grids must be improved during the fault period.This study proposes an integrated multiport flexible voltage clamp circuit breaker with a DC chopper acting on the receiving end converter to solve the DC short circuit fault and surplus power because of AC low-voltage fault;it has a modular design.As a DC circuit breaker,the device utilizes the voltage-clamping principle and thyristor semi-control to remove faults.As the fault current increases,the branch circuit outputs different voltage levels by selecting different gears,thereby controlling the voltage-clamping effect.This device can distinguish between different fault types to prevent secondary shocks in the system.As a DC chopper,the voltage at both ends of the energy dissipation resistor is varied by switching submodules,consuming surplus power to complete AC low-voltage faults and minimizing the impact of low-voltage faults on the system’s transmission capacity.Finally,the effectiveness and applicability of the equipment are verified using wind turbines connected to a flexible DC transmission three-terminal power grid model in PSCAD/EMTDC,and two fault simulation types are analyzed.A comparison of the electrical quantities(fault current,system voltage and branch voltage)of the proposed circuit breaker with other similar equipment shows that due to the efficiency of the proposed equipment,the peak fault current is reduced by at least 35.8%.The required voltage stress of key power electronic equipment is reduced by at least 71.5%.Therefore,the equipment ensures that the per-unit voltage of the DC system does not exceed 1.05 during AC fault crossing.
文摘Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.
基金funded by Youth Talent Growth Project of Guizhou Provincial Department of Education(No.Qianjiaoji[2024]21)National Natural Science Foundation of China(No.62461008 and No.52507211)Guizhou Provincial Key Technology R&D Program(No.[2024]General 049).
文摘To address the issues of high costs and low component utilization caused by the independent configuration of hybrid DC circuit breakers(HCBs)and DC power flow controllers(DCPFCs)at each port in existing DC distribution networks,this paper adopts a component sharing mechanism to propose a composite multi-port hybrid DC circuit breaker(CM-HCB)with DC power flow and fault current limitation abilities,as well as reduced component costs.The proposed CM-HCB topology enables the sharing of the main breaker branch(MB)and the energy dissipation branch,while the load commutation switches(LCSs)in the main branch are reused as power flow control components,enabling flexible regulation of power flow in multiple lines.Meanwhile,by reconstructing the current path during the fault process,the proposed CM-HCB can utilize the internal coupled inductor to limit the current rise rate at the initial stage of the fault,significantly reducing the requirement for breaking current.A detailed study on the topological structure,steady-state power flow regulation mechanism,transient fault isolation mechanism,control strategy and characteristic analysis of the proposed CM-HCB is presented.Then,a Matlab/Simulink-based meshed three-terminal DC grid simulation platform with the proposed CM-HCB is built.The results indicate that the proposed CM-HCB can not only achieve flexible power flow control during steady-state operation,but also obtain current rise limitation and fault isolation abilities under short-circuit fault conditions,verifying its correctness and effectiveness.Finally,a comparative economic analysis is conducted between the proposed CM-HCB and the other two existing solutions,confirming that its component sharing mechanism can significantly reduce the number of components,lower system costs,and improve component utilization.
基金supported by the Medical Research Council(MR/T030143/1)grant and the University of Manchester。
文摘The mammalian cerebral cortex,despite its variation in brain shape and size,is a stereotypical six-layered structure composed of pyramidal cells,interneurons,astrocytes,microglia,oligodendrocytes,and endothelial cells.During development,these cells differ in their origin,birth timing,and developmental trajectories.Nonetheless,they converge during development,forming nascent cortical circuits crucial for organismal behavior.While the relative proportions of cortical cells vary between regions.
文摘The concept of the imperfection sensitive region is given. The advanced stochastic imperfection method is used to research the imperfection sensitive region of single-layer latticed domes. Taking a K6 single-layer latticed dome with a diameter of 50 m as an example, its imperfection sensitive region is made up of the first 12 kinds of joints. The influence of the imperfections of support joints on the stability of the K6 single-layer latticed dome is negligible. Influences of the joint imperfections of the main rib and the secondary rib on the structural stability are similar. The initial deviations of these joints all greatly lower the critical load of the dome. Results show that the method can analyze the structural imperfection sensitive region quantitatively and accurately.
基金the financial support for this work by the National Natural Science Foundation of China (No.51235004 and No.51375235)the Fundamental Research Funds for the Central Universities (No.NE2014103)the Science and Technology Supporting Program of Jiangsu Province (No.BE2013109 and No.BY2014003-008)
文摘In order to develop the high-efficiency and precision machining technique of TiCp/Ti - 6Al-4V particulate reinforced titanium matrix composites （PTMCs）, high-speed grinding experiments were conducted using the single-layer electroplated cubic boron nitride （CBN） wheel and brazed CBN wheel, respectively. The comparative grinding performance was studied in terms of grinding force, grinding temperature, grinding-induced surface features and defects. The results display that the grinding forces and grinding temperature obtained with the brazed CBN wheel are always lower than those with the electroplated CBN wheel. Though the voids and microcracks are the dominant grinding-induced surface defects, the brazed CBN wheel produces less surface defects compared to the electroplated wheel according to the statistical analysis results. The max mum materials removal rate with the brazed CBN wheel is much higher than that with the electroplated one. All above indicate that the single-layer brazed CBN super-abrasive wheel is more suitable for high-speed grinding of PTMCs than the electroplated counterpart.
基金Supported by the National Key Research and Development Program of China under Grant No 2016YFA0300404the National Basic Research Program of China under Grant No 2015CB921202+2 种基金the National Nature Science Foundation of China under Grant Nos 11574133 and 11834006the Nature Science Foundation of Jiangsu Province under Grant No BK20150012the Fundamental Research Funds for the Central Universities,the Science Challenge Project(No TZ2016001)
文摘Single-layer superconductors are ideal materials for fabricating superconducting nano devices.However,up to date,very few single-layer elemental superconductors have been predicted and especially no one has been successfully synthesized yet.Here,using crystal structure search techniques and ab initio calculations,we predict that a single-layer planar carbon sheet with 4-and 8-membered rings called T-graphene is a new intrinsic elemental superconductor with superconducting critical temperature(Tc)up to around 20.8 K.More importantly,we propose a synthesis route to obtain such a single-layer T-graphene,that is,a T-graphene potassium intercalation compound(C4 K with P4/mmm symmetry)is firstly synthesized at high pressure(>11.5 GPa)and then quenched to ambient condition;and finally,the single-layer T-graphene can be either exfoliated using the electrochemical method from the bulk C4 K,or peeled off from bulk T-graphite C4,where C4 can be obtained from C4 K by evaporating the K atoms.Interestingly,we find that the calculated Tc of C4 K is about 30.4 K at 0 GPa,which sets a new record for layered carbon-based superconductors.The present findings add a new class of carbon-based superconductors.In particular,once the single-layer T-graphene is synthesized,it can pave the way for fabricating superconducting devices together with other 2 D materials using the layer-by-layer growth techniques.
基金the Natural Science Basic Research Plan in Shaanxi Province of China(Nos.2021JQ-190,2020JM-82)the Fundamental Research Funds for the Central Universities(No.QTZX2146)。
文摘MXenes,a family of two-dimensional(2D)materials,exhibit peculiar microwave-absorbing behaviors due to their unique chemical composition and structure.Although laminated Ti_(3)C_(2)T_(x) MXenes with a multilayer structure have been used for microwave absorption,real 2D MXenes with a single-layer structure have not yet been investigated.Here,the electromagnetic wave response behavior of single-layer Ti_(3)C_(2)T_(x) MXenes was explored in detail.The permittivity of Ti_(3)C_(2)T_(x) MXene rises dramatically with an increase in filler loading,and Ti_(3)C_(2)T_(x) MXene features a distinct dielectric response wherein dipolar polarization and interfacial polarization makes a greater contribution at low filler loading;conductive loss becomes more prominent at high filler loading.Versus laminated Ti_(3)C_(2)T_(x) MXene,single-layer Ti_(3)C_(2)T_(x) MXene delivers superior absorbing capability:The RLminvalue of SL-Ti_(3)C_(2)T_(x)-22%reaches-43.5 d B at 6.5 GHz,and a broad EAB of 6.88 GHz can be attained at a thickness of 1.8 mm due to enhanced dipolar polarization,interfacial polarization,and conductive loss.This work is of great significance in guiding the future development of MXene-based absorbers.
基金National Natural Science Foundation of China,Grant No.59895410
文摘The single-layer latticed cylindrical shell is one of the most widely adopted space-fl'amed structures.In this paper,free vibration properties and dynamic response to horizontal and vertical seismic waves of single-layer latticed cylindrical shells are analyzed by the finite element method using ANSYS software.In the numerical study,where hundreds of cases were analyzed,the parameters considered included rise-span ratio,length-span ratio,surface load and member section size.Moreover,to better define the actual behavior of single-layer latticed shells,the study is focused on the dynamic stress response to both axial forces and bending moments.Based on the numerical results,the effects of the parameters considered on the stresses are discussed and a modified seismic force coefficient method is suggested.In addition,some advice based on these research results is presented to help in the future design of such structures.
文摘Based on vibration analysis, single-layered graphene sheet （SLGS） with multiple attached nanoparticles is developed as nanoscale mass sensor in thermal environments. Graphene sensors are assumed to be in simplysupported configuration. Based on the nonlocal plate the- ory which incorporates size effects into the classical theory, closed-form expressions lot the frequencies and relative fre- quency shills of SLGS-based mass sensor are derived using the Galerkin method. The suggested model is justified by a good agreement between the results given by the present model and available data in literature. The effects of tem- perature difference, nonlocal parameter, the location of the nanoparticle and the number of nanoparticles on the relative frequency shift of the mass sensor are also elucidated. The obtained results show that the sensitivity of the SLGS- based mass sensor increases with increasing temperature difference.
基金Project supported by the National Natural Science Foundation of China(Grant No.61372034)
文摘Circularly polarized （CP） lens antenna has been applied to numerous wireless communication systems based on its unique advantages such as high antenna gain, low manufacturing cost, especially stable data transmission between the transmitter and the receiver. Unfortunately, current available CP lens antennas mostly suffer from high profile, low aperture efficiency as well as complex design. In this paper, we propose an ultra-thin CP lens antenna based on the designed single- layered Pancharatnam-Berry （PB） transparent metasurface with focusing property. The PB metasurface exhibits a high transmissivity, which ensures a high efficiency of the focusing property. Launched the metasurface with a CP patch antenna at its focal point, a low-profile lens antenna is simulated and measured. The experimental results show that our lens antenna exhibits a series of advantages including high radiation gain of 20.7 dB, aperture efficiency better than 41.3%, and also narrow half power beam width （HPBW） of 13°at about 14GHz. Our finding opens a door to realize ultra-thin transparent metasurface with other functionalities or at other working frequencies.
文摘We report near-zero crossover for vanadium cross-permeation through single-layer graphene immobilized at the interface of two Nafion?polymer electrolyte membranes.Vanadium ion diffusion and migration,including proton mobility through membrane composites,were studied with and without graphene under diffusion and migration conditions.Single-layer graphene was found to effectively inhibit vanadium ion diffusion and migration under specific conditions.The single-layer graphene composites also enabled remarkable ion transmission selectivity improvements over pure Nafion membranes,with proton transport being four orders of magnitude faster than vanadium ion transport.Resistivity values of 0.02±0.005Ωcm^(2) for proton and 223±4Ωcm^(2) for vanadium ion through single atomic layer graphene are reported.This high selectivity may have significant impact on flow battery applications or for other electrochemical devices where proton conductivity is required,and transport of other species is detrimental.Our results emphasize that crossover may be essentially completely eliminated in some cases,enabling for greatly improved operational viability.
基金Sponsored by the National Natural Science Foundation of China(Grant No.90715034)
文摘To study the damage mechanism of single-layer reticulated domes subject to severe earthquakes, three limit states of single-layer reticulated domes under earthquakes are defined firstly in this paper. Then, two failure modes are presented by analyzing damage behaviors, and their characteristics are pointed out respectively. Furthermore, the damage process is analyzed and the causes of structural damage in different levels are studied. Finally, by comparing deformation and vibration status of domes with different failure modes, the principles of different failures are revealed and an integrated frame of damage mechanism is set up.
