Realistic models for cancer research representing disease progression that commensurately respond to therapeutics consistent with clinical observation are the holy grail for pre-clinical research and screening.Althoug...Realistic models for cancer research representing disease progression that commensurately respond to therapeutics consistent with clinical observation are the holy grail for pre-clinical research and screening.Although such an ideal is elusive,well-characterized in vivo models facilitate our understanding of disease,progression,and therapeutic opportunities.Here,we characterize a commonly used syngeneic BALB/c mouse model of triple negative breast cancer(4T1)after establishing tumors in their flanks.Tumors developed at the subcutaneous injection site for all experimental mice and their volumes were monitored.We quantified a rare subset of breast cancer stemlike cells(CSCs),classified as CD44^(+)/CD24^(−)phenotypes in in vitro and ex vivo cell populations.Chromosome numbers in ex vivo metaphase cells were greater than cells cultured in vitro(89.4±3.4,range of 70-132 and 82.6±1.1,range of 70-128;respectively).Further,we observed different types of chromosome aberrations,including gap,deletion,exchange,interstitial deletion,terminal deletion,ring,dicentric,and Robertsonian translocations.For both sources of cells,the number of aberrations was dominated by deletions,terminal deletions,and Robertsonian translocations.Ex vivo cells exhibited greater prevalence of deletions and terminal deletions,whereas in vitro cells displayed more ring aberrations and Robertsonian translocations.In conclusion,we successfully characterized cancer cells from a syngeneic mouse model of breast cancer in terms of rare CSC proportion and a variety of chromosomal aberrations,which is useful for understanding tumor traits associated with cancer development and therapeutic action.The data act as a valuable resource for other studies using the 4T1 BALB/c model.展开更多
In this paper,we present a circuit model of single-quantum-well InGaN/GaN light-emitting diodes based on the standard rate equations.Two rate equations describe carrier transport processes occurring in sep-arate confi...In this paper,we present a circuit model of single-quantum-well InGaN/GaN light-emitting diodes based on the standard rate equations.Two rate equations describe carrier transport processes occurring in sep-arate confinement heterostructure and quantum well respectively,and the third equation describes the varied photons in quantum well.By using the presented model,impacts of quantum well thickness on the static and dynamic performances are investigated.Simulated results show that LED with 4 nm well exhibits better lightcurrent(L-I)performance,but LED with 3 nm well presents wider 3 dB modulation bandwidth.It reveals that high carrier density in quantum well is detrimental to the static performance,but beneficial to the dynamic performance.展开更多
Background 3D botanical tree reconstruction from a single image plays a vital role in the field of computer graphics.However,accurately capturing the intricate branching patterns and detailed morphologies of trees rem...Background 3D botanical tree reconstruction from a single image plays a vital role in the field of computer graphics.However,accurately capturing the intricate branching patterns and detailed morphologies of trees remains a challenge.Methods In this study,we proposed a novel approach for single-image tree reconstruction using a conditional generative adversarial network to infer the 3D skeleton of a tree in the form of a 2D skeleton depth map.Based on the 2D skeleton depth map,a corresponding branching structure(3D skeleton)that inherits the tree shape in the input image and leaves can be generated using a procedural modeling technique.Result Experimental results show that the proposed method accurately reconstructs diverse tree structures across species.Both quantitative and qualitative evaluations demonstrate improved skeleton completeness,branching accuracy,and visual realism over baseline methods,while requiring no user input.Conclusions Our proposed approach for generating lifelike 3D tree models from a single image with no user input shows its proficiency in achieving efficient and reliable reconstruction.These results showcase the capability of the proposed model to recreate complex tree architectures while capturing their visual authenticity.展开更多
The increase in human population has led to imminent pressures to develop new edible proteins with decreased environmental footprints.The most promising approach involves the production of single cell protein(SCP)from...The increase in human population has led to imminent pressures to develop new edible proteins with decreased environmental footprints.The most promising approach involves the production of single cell protein(SCP)from yeasts,which have been utilized in a wide variety of foods for thousands of years.In this study,102 yeast strains isolated from traditional fermented pork(Nanx Wudl)were investigated for their potential as SCP producer for the first time.Based on preliminary screening,Saccharomyces cerevisiae Y70 and Candida parapsilosis H5Y13,both showing high protein content and excellent growth capability,were selected for further analysis via 4D-DIA proteomics technology.Proteomic analysis indicated that the oxidative metabolism pathways,including TCA cycle,oxidative phosphorylation and pentose phosphate pathway,may have a significant impact on global protein synthesis and production.This study provides useful information for selecting SCP-producing yeast from Chinese fermented meat products and contribute to a deeper understanding of the underlying metabolic mechanisms behind global protein synthesis in yeast.Furthermore,these findings also provide potential molecular targets for genetic engineering modifications in yeast,aimed at constructing highly efficient cell factories for protein production.展开更多
High-performance lead-free piezoelectric single crystals are urgently needed for next-generation actuators and transducers.In this study,we reveal that a compositionally driven tetragonal-pseudocubic(T-PC)phase bounda...High-performance lead-free piezoelectric single crystals are urgently needed for next-generation actuators and transducers.In this study,we reveal that a compositionally driven tetragonal-pseudocubic(T-PC)phase boundary,in conjunction with an octahedral order-disorder tilting transition,significantly enhances the piezoelectric response in Nb^(5+)-substitution(Bi_(0.48)Na_(0.425)K_(0.055)Ba_(0.04))(Ti_(0.98)Nb_(0.02))O_(3)(BNKBT-2Nb)single crystals.The crystal achieves an outstanding piezoelectric coefficient of d33=662 pC/N at room temperature.In situ X-ray diffraction confirms an electric field-induced transition from the PC to T phase.Atomic-resolution HADDF-STEM analysis reveals an increase in the c/a ratio(c/a>1.01)on the local scale and ordered octahe-dral tilting of the a^(0)a^(0)c+type driven by the poling field.The single crystals exhibit excellent piezoelectric per-formance over a broad temperature range,achieving a peak d_(33) of 920 pC/N at approximately 92℃.Furthermore,the polar states exhibit a pronounced frequency dependence near the depolarization temperature.These findings provide critical insight into the structure-property relationship and offer a promising pathway for designing advanced lead-free piezoelectric crystals for functional electromechanical applications.展开更多
Pediatric cancers are particularly significant due to their uncommon occurrence in children,driven by a variety of underlying factors.Because of their distinct molecular and genetic makeup,which makes early detection ...Pediatric cancers are particularly significant due to their uncommon occurrence in children,driven by a variety of underlying factors.Because of their distinct molecular and genetic makeup,which makes early detection challenging,they are linked to problems.Diagnostic methods like imaging and tissue biopsy are only effective when the tumor has reached a size that can be identified.The liquid biopsy technique,the least intrusive and most convenient diagnostic method,is the subject of this review.It focuses on the significance of single cell analysis in examining uncommon cancer types.The many biomarkers found in bodily fluids and the cancer types they are linked to in children have been assessed,as has the potential route towards early detection and cancer recurrence forecasting.Combining the single cell liquid biopsy with the newest technologies,such as computational and multi-omics approaches,which have improved the efficiency of processing massive and unique genetic data,appears promising.This article discusses on a number of case reports for uncommon pediatric malignancies,such as Neuroblastoma,Medulloblastoma,Wilms Tumor,Rhabdomyosarcoma,Ewing Sarcoma,and Retinoblastoma,as well as their liquid biopsy profiles.Furthermore,the findings raise ethical questions regarding the therapeutic application of the technology as well as possible difficulties related to clinical translation.The likelihood that this single cell liquid biopsy will be clinically validated and eventually used as a routine diagnostic tool for uncommon pediatric cancers will rise with the realistic approach to sensitivity monitoring,specificity upgrading,and optimization.展开更多
Sliver defects are a group of low-to-medium angle misoriented grains in Ni-based single crystal superalloys that have received more attention in recent years.Occurrence of these defects can negatively affect the mecha...Sliver defects are a group of low-to-medium angle misoriented grains in Ni-based single crystal superalloys that have received more attention in recent years.Occurrence of these defects can negatively affect the mechanical properties of single crystal components.Therefore,studying the mechanisms of sliver formation and its effects on the final properties of alloys is of great importance.In this article,recent studies on the sliver defects were reviewed.Accordingly,the mechanisms of sliver formation as well as factors contributing to sliver initiation were studied.Additionally,effects of slivers on the mechanical properties of single crystal superalloys were discussed.Dendrite deformation and dendrite fracture are the main mechanisms for the sliver formation.This is a consequence of local stress concentration on dendrites during solidification.Therefore,locations such as inclusions,pores,geometrically complex areas,mould walls,freckle channels,etc.can be considered as the potential factors that promote the sliver initiation.Sliver formation significantly degrades the creep life of single-crystal superalloys.Studies have shown that when crystallographic misorientation exceeds approximately15°,creep life can be reduced by up to 47%.Despite the absence of a standardized criterion for predicting or preventing sliver initiation and propagation,their occurrence can be minimized through optimization of solidification parameters,careful grain selection,proper casting geometry design,and rigorous control of material purity and equipment conditions.展开更多
Fenton-like technology based on peroxymonosulfate activation has shown great potential in refractory organics degradation.In this work,single Fe atom catalysts were synthesized through facile ball milling and exhibite...Fenton-like technology based on peroxymonosulfate activation has shown great potential in refractory organics degradation.In this work,single Fe atom catalysts were synthesized through facile ball milling and exhibited very high performance in peroxymonosulfate activation.The Fe single-atom filled an N vacancy on the triazine ring edge of C_(3)N_(4),as confirmed through X-ray absorption fine structure,density functional calculation and elec-tron paramagnetic resonance.The SAFe_(0.4)–C_(3)N_(4)/PMS system could completely remove phenol(20 mg/L)within 10 min and its first-order kinetic constant was 12.3 times that of the Fe_(3)O_(4)/PMS system.Under different ini-tial pH levels and in various anionic environments,SAFe_(0.4)–C_(3)N_(4) still demonstrated excellent catalytic activity,achieving a removal rate of over 90%for phenol within 12 min.In addition,SAFe_(0.4)–C_(3)N_(4) exhibited outstanding selectivity in reaction systems with different pollutants,showing excellent degradation effects on electron-rich pollutants only.Hydroxyl radicals(•OH),singlet oxygen(1O_(2))and high-valent iron oxide(Fe(Ⅳ)=O)were de-tected in the SAFe_(0.4)–C_(3)N_(4)/PMS system through free radical capture experiments.Further experiments on the quenching of active species and a methyl phenyl sulfoxide probe confirmed that 1O_(2) and Fe(Ⅳ)=O played dom-inant roles.Additionally,the change in the current response after adding PMS and phenol in succession proved that a direct electron transfer path between organic matter and the catalyst surface was unlikely to exist in the SAFe_(0.4)–C_(3)N_(4)/PMS/Phenol degradation system.This study provides a new demonstration of the catalytic mech-anism of single-atom catalysts.展开更多
Nickel-based single-crystal superalloy DD98M is widely used in high-temperature components such as aero-engines and gas turbines.Since it has only one crystal grain,the theory of slip deformation along the grain bound...Nickel-based single-crystal superalloy DD98M is widely used in high-temperature components such as aero-engines and gas turbines.Since it has only one crystal grain,the theory of slip deformation along the grain boundary of polycrystalline material is not suitable for the machining of a single crystal part.Therefore,micro-drilling of nickel-based single crystal superalloy still faces problems such as unclear cutting formation me-chanism and unclear surface/subsurface damage mechanism.In this paper,the formation mechanism and morphological characteristics of chips and burrs were studied by a single-factor experiment,and the plastic deformation rule and damage mechanism were investigated,combined with the changes of subsurface structure and grain type.Finally,the influence of the law and reason of tool wear condition on the hole wall and the drilled subsurface is analyzed.The experimental results indicate that drill chips mainly exhibit three morphologies.Their free surfaces feature a serrated appearance,while the contact surfaces are smooth.The entrance burrs are mainly flanging burrs.With the increase of spindle speed,the burr height decreases from 49.38 to 9.39μm.As the feed speed increases,the burr height increases from 6.50 to 63.87μm.The drilled subsurface can be divided into a white layer region,a plastic deformation region,and the matrix according to the microstructural change.As the depth from the machined surface increases,the degree of plastic deformation of the material decreases,the grain size gradually reduces,and the dislocation density decreases.Stacking fault and twinning mostly occur in the high-plastic deformation region,and recrystallization occurs on the machined surface.As the drilling length increases,the degree of tool wear increases,and the adhesion and ablation area on the hole wall surface increase.Moreover,the thickness of the white layer increases from 0 to 8.75μm,and the thickness of the plastic deformation layer increases from 1.28 to 11.31μm.The study has significant theoretical and practical implications for the efficient and low-damage machining of micro-holes in the nickel-based single crystal superalloy.展开更多
Turbine blades,due to their intricate geometry,are exposed to multiaxial stresses during operation.Consequently,it is imperative to examine the anisotropy of their stress-rupture behavior across various testing scenar...Turbine blades,due to their intricate geometry,are exposed to multiaxial stresses during operation.Consequently,it is imperative to examine the anisotropy of their stress-rupture behavior across various testing scenarios,particularly under high-temperature conditions.Stress-rupture behavior of a Ni-based single crystal superalloy was investigated under a load varying from 100 MPa to 137 MPa at 1,100℃ for both[001]-and[111]-orientated specimens.Results demonstrate that the rupture behavior of[111]-orientated specimens exhibits obviously higher sensitive to applied stress compared to[001]-orientated specimens.This difference is primarily attributed to the orientation dependentγ'coarsening behavior and distinct dislocation interactions atγ/γ'interfaces.In[001]-oriented specimens,plate-likeγ/γ'rafts rapidly form alongside well-developed interfacial dislocation networks,where theγ/γ'misfit stress dominates the microstructural evolution.In contrast,the[111]-orientated specimens exhibit retained,coarsenedγ'precipitates embedded within theγmatrix,accompanied by poorly developed interfacial dislocation networks.展开更多
The single electron capture processes in Si^(3,4+)+He collisions have been investigated theoretically employing the two-center atomic orbital close-coupling method in the energy range 0.01-100 keV/u.Total and state-se...The single electron capture processes in Si^(3,4+)+He collisions have been investigated theoretically employing the two-center atomic orbital close-coupling method in the energy range 0.01-100 keV/u.Total and state-selective electron capture cross sections for the dominant and subdominant reaction channels are calculated and compared with the available experimental and theoretical data.For the total charge transfer cross sections,the present results show better agreements with the available experimental data than the other theoretical ones in the overlapping energy region for both collision systems.For the state-selective cross sections,the present results for 3s and 3p states are in general agreement with the previous MOCC results in the low energy region for both collision systems.Furthermore,the cross sections for electron captured to the 3d,4l and 5l(l=0,1,...,n-1)states of Si^(2+)and Si^(3+)ions are first provided in a broad energy region in our work.These results are useful for the investigations in astrophysics.The datasets presented in this paper,including the total and state-selective electron capture cross sections of Si^(3,4+)+He collisions in 0.01-100 ke V/u,are openly available at https://doi.org/10.57760/sciencedb.j00113.00257.展开更多
High-performance fiber fabrics and composites experienced transverse compression deformation at ultrahigh strain rates near the impact point when subjected to high-velocity impacts,which significantly affected their b...High-performance fiber fabrics and composites experienced transverse compression deformation at ultrahigh strain rates near the impact point when subjected to high-velocity impacts,which significantly affected their ballistic limits.In this paper,a fiber-scale experimental method for characterizing ultrahigh strain-rate transverse compression behavior was proposed.To begin with,in order to measure the extremely low stress and strain in small specimens,the conventional Hopkinson bar was reduced to the hundred-micron scale,thereby achieving wave impedance matching with single fibers.In addition,tangential and normal laser Doppler velocimetry(LDV)methods were employed to realize non-contact,high-precision,and high-speed axial velocity measurements of micron-scale incident and transmission bars,respectively.Meanwhile,a microscopic observation system was used to facilitate the installation of miniature fiber samples.The experimental setup and procedures were introduced,and the system accuracy was verified through sample-free loading tests based on one-dimensional stress wave propagation theory.Dynamic compression experiments on Graphene-UHMWPE fibers were carried out,followed by post-compression microstructural characterization via scanning electron microscopy(SEM).Results demonstrated that successful mechanical characterization was achieved at strain rates exceeding 105,an order of magnitude higher than the previously reported maximum rates.Furthermore,during the loading process,the fibers underwent uniform compression deformation while exhibiting pronounced strain-rate effects.This method offers a novel approach for dynamic mechanical characterization of microscale single fibers,enabling the development of comprehensive strain-ratedependent material models to guide the design of advanced composites and high-performance fibers.展开更多
In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave so...In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.展开更多
Unlike mammals,zebrafish possess a remarkable ability to regenerate their spinal cord after injury,making them an ideal vertebrate model for studying regeneration.While previous research has identified key cell types ...Unlike mammals,zebrafish possess a remarkable ability to regenerate their spinal cord after injury,making them an ideal vertebrate model for studying regeneration.While previous research has identified key cell types involved in this process,the underlying molecular and cellular mechanisms remain largely unexplored.In this study,we used single-cell RNA sequencing to profile distinct cell populations at different stages of spinal cord injury in zebrafish.Our analysis revealed that multiple subpopulations of neurons showed persistent activation of genes associated with axonal regeneration post injury,while molecular signals promoting growth cone collapse were inhibited.Radial glial cells exhibited significant proliferation and differentiation potential post injury,indicating their intrinsic roles in promoting neurogenesis and axonal regeneration,respectively.Additionally,we found that inflammatory factors rapidly decreased in the early stages following spinal cord injury,creating a microenvironment permissive for tissue repair and regeneration.Furthermore,oligodendrocytes lost maturity markers while exhibiting increased proliferation following injury.These findings demonstrated that the rapid and orderly regulation of inflammation,as well as the efficient proliferation and redifferentiation of new neurons and glial cells,enabled zebrafish to reconstruct the spinal cord.This research provides new insights into the cellular transitions and molecular programs that drive spinal cord regeneration,offering promising avenues for future research and therapeutic strategies.展开更多
Temperature-dependent resistivity,upper critical field H_(c2)and its anisotropy in overdoped superconducting Ba_(1-x)K_x Fe_2As_2(x=0.6-1)single crystals have been measured in steady magnetic fields up to 44 T and low...Temperature-dependent resistivity,upper critical field H_(c2)and its anisotropy in overdoped superconducting Ba_(1-x)K_x Fe_2As_2(x=0.6-1)single crystals have been measured in steady magnetic fields up to 44 T and low temperatures down to 0.4 K.Analysis using both the quadratic term and power-law fitting demonstrates that the in-plane resistivityρ_(ab)(T)progressively approaches the Fermi-liquid T~2behavior with increasing K doping and reaches a saturation plateau at x≈0.8.The temperature dependence of both H_(c2)^(ab)and H^(c)_(c2)follows the Werthamer-Helfand-Hohenberg model,incorporating orbital and spin paramagnetic effects.For x≤0.8,the orbital effect dominates for H ab,while the Pauli paramagnetic effect prevails for H c.For x>0.8,the Pauli paramagnetic effect becomes dominant in both crystallographic directions.The anisotropy of H_(c2)(0)exhibits a discontinuity in its dependence on K doping concentration with a significant enhancement at x=0.8 and a maximum at x=0.9.These experimental results indicate that the electron correlation effect is enhanced in the heavily overdoped Ba_(1-x)K_(x)Fe_(2)As_(2)system where the underlying symmetries are broken due to the Fermi surface reconstruction before x=0.9.展开更多
Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other...Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other diseases often observed in a patient’s history in addition to their AD diagnosis,make deciphering the molecular mechanisms that underlie AD,even more important.Large datasets of single-cell RNA sequencing,single-nucleus RNA-sequencing(snRNA-seq),and spatial transcriptomics(ST)have become essential in guiding and supporting new investigations into the cellular and regional susceptibility of AD.However,with unique technology,software,and larger databases emerging;a lack of integration of these data can contribute to ineffective use of valuable knowledge.Importantly,there was no specialized database that concentrates on ST in AD that offers comprehensive differential analyses under various conditions,such as sex-specific,region-specific,and comparisons between AD and control groups until the new Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)database(Wang et al.,2024)was introduced to meet the scientific community’s growing demand for comprehensive,integrated,and accessible data analysis.展开更多
The development of quantum materials for single-photon emission is crucial for the advancement of quantum information technology.Although significant advancements have been witnessed in recent years for single-photon ...The development of quantum materials for single-photon emission is crucial for the advancement of quantum information technology.Although significant advancements have been witnessed in recent years for single-photon sources in the near-infrared band(λ∼700–1000 nm),several challenges have yet to be addressed for ideal single-photon emission at the telecommunication band.In this study,we present a droplet-epitaxy strategy for O-band to C-band single-photon source-based semiconductor quantum dots(QDs)using metal-organic vaporphase epitaxy(MOVPE).By investigating the growth conditions of the epitaxial process,we have successfully synthesized InAs/InP QDs with narrow emission lines spanning a broad spectral range of λ∼1200–1600 nm.The morphological and optical properties of the samples were characterized using atomic force microscopy and microphotoluminescence spectroscopy.The recorded single-photon purity of a plain QD structure reaches g^((2))(0)=0.16,with a radiative recombination lifetime as short as 1.5 ns.This work provides a crucial platform for future research on integrated microcavity enhancement techniques and coupled QDs with other quantum photonics in the telecom bands,offering significant prospects for quantum network applications.展开更多
Accurate prediction of wind energy plays a vital role in maintaining grid stability and supporting the broader shift toward renewable energy systems.Nevertheless,the inherently variable nature of wind and the intricac...Accurate prediction of wind energy plays a vital role in maintaining grid stability and supporting the broader shift toward renewable energy systems.Nevertheless,the inherently variable nature of wind and the intricacy of high-dimensional datasets pose major obstacles to reliable forecasting.To address these difficulties,this study presents an innovative hybrid method for short-term wind power prediction by combining a Long Short-Term Memory(LSTM)network with a Single Candidate Optimizer(SCO)algorithm.In contrast to conventional techniques that rely on random parameter initialization,the proposed LSTM-SCO framework leverages the distinctive capability of SCO to work with a single candidate solution,thereby substantially reducing the computational overhead compared to traditional population-based metaheuristics.The performance of the model was benchmarked against various classical and deep learning models across datasets from three geographically diverse sites,using multiple evaluation metrics.Experimental findings demonstrate that the SCO-optimized model enhances prediction accuracy by up to 12.5%over standard LSTM implementations.展开更多
BACKGROUND Ischemic heart disease(IHD)impacts the quality of life and has the highest mortality rate of cardiovascular diseases globally.AIM To compare variations in the parameters of the single-lead electrocardiogram...BACKGROUND Ischemic heart disease(IHD)impacts the quality of life and has the highest mortality rate of cardiovascular diseases globally.AIM To compare variations in the parameters of the single-lead electrocardiogram(ECG)during resting conditions and physical exertion in individuals diagnosed with IHD and those without the condition using vasodilator-induced stress computed tomography(CT)myocardial perfusion imaging as the diagnostic reference standard.METHODS This single center observational study included 80 participants.The participants were aged≥40 years and given an informed written consent to participate in the study.Both groups,G1(n=31)with and G2(n=49)without post stress induced myocardial perfusion defect,passed cardiologist consultation,anthropometric measurements,blood pressure and pulse rate measurement,echocardiography,cardio-ankle vascular index,bicycle ergometry,recording 3-min single-lead ECG(Cardio-Qvark)before and just after bicycle ergometry followed by performing CT myocardial perfusion.The LASSO regression with nested cross-validation was used to find the association between Cardio-Qvark parameters and the existence of the perfusion defect.Statistical processing was performed with the R programming language v4.2,Python v.3.10[^R],and Statistica 12 program.RESULTS Bicycle ergometry yielded an area under the receiver operating characteristic curve of 50.7%[95%confidence interval(CI):0.388-0.625],specificity of 53.1%(95%CI:0.392-0.673),and sensitivity of 48.4%(95%CI:0.306-0.657).In contrast,the Cardio-Qvark test performed notably better with an area under the receiver operating characteristic curve of 67%(95%CI:0.530-0.801),specificity of 75.5%(95%CI:0.628-0.88),and sensitivity of 51.6%(95%CI:0.333-0.695).CONCLUSION The single-lead ECG has a relatively higher diagnostic accuracy compared with bicycle ergometry by using machine learning models,but the difference was not statistically significant.However,further investigations are required to uncover the hidden capabilities of single-lead ECG in IHD diagnosis.展开更多
Many studies have shown the negative relationship between long term exposure to PM_(2.5)and cardiac dysfunction.Recently,studies have shown that even a single exposure of PM_(2.5)from air sample in permissible range c...Many studies have shown the negative relationship between long term exposure to PM_(2.5)and cardiac dysfunction.Recently,studies have shown that even a single exposure of PM_(2.5)from air sample in permissible range can induce very mild cardiac pathological changes.In the present study,we revisited the toxic effect of PM_(2.5)on rat heart by adopting single and multiple exposure durations.FemaleWistar ratswere exposed to PM_(2.5)at a concentration of 250μg/m3 daily for 3 hr for single(1 day)and multiple(7,14,21 days)durations.The major pathological changes noted in 21 days exposed myocardium comprised of an elevated ST segment(the segment between the S wave and the T wave),development of cardiac fibrosis,hypertrophy,cardiac injury,tissue inflammation and declined cardiac function.With 14 days exposed heart,the electrocardiograms(ECG),data showed insignificantly declined heart rate and an increased QT(the time from the start of the Q wave to the end of the T wave)interval along with mild fibrosis,hypertrophy and lesser number of TUNEL positive cells.On the other hand,single-and 7-days exposure to PM_(2.5)did not impart any significant changes in the myocardium.To determine the reversibility potential of PM_(2.5)induced cardiotoxicity,a washout period of 24 hours was adopted and all observed changes in the myocardium were reversed till day 7,but not in 14-and 21-days exposed samples.Based on the above findings we concluded that PM_(2.5)associated cardiac dysfunction is the cumulative outcome of ineffective cardiac adaptive and repair process that accumulate additively over the time due to prolonged exposure durations.展开更多
基金National Research,Development and Innovation Fund of the Ministry of Culture and Innovation under the National Laboratories Program(National Tumor Biology Laboratory,Grant/Award Number:2022-2.1.1-NL-2022-00010)Senior Research Fellowship from National Health and Medical Research Council of Australia,Grant/Award Number:1156693+1 种基金Hungarian Thematic Excellence Program,Grant/Award Number:TKP2021-EGA-44Tour de Cure,Pioneering Grant,Grant/Award Number:RSP-253-18/19。
文摘Realistic models for cancer research representing disease progression that commensurately respond to therapeutics consistent with clinical observation are the holy grail for pre-clinical research and screening.Although such an ideal is elusive,well-characterized in vivo models facilitate our understanding of disease,progression,and therapeutic opportunities.Here,we characterize a commonly used syngeneic BALB/c mouse model of triple negative breast cancer(4T1)after establishing tumors in their flanks.Tumors developed at the subcutaneous injection site for all experimental mice and their volumes were monitored.We quantified a rare subset of breast cancer stemlike cells(CSCs),classified as CD44^(+)/CD24^(−)phenotypes in in vitro and ex vivo cell populations.Chromosome numbers in ex vivo metaphase cells were greater than cells cultured in vitro(89.4±3.4,range of 70-132 and 82.6±1.1,range of 70-128;respectively).Further,we observed different types of chromosome aberrations,including gap,deletion,exchange,interstitial deletion,terminal deletion,ring,dicentric,and Robertsonian translocations.For both sources of cells,the number of aberrations was dominated by deletions,terminal deletions,and Robertsonian translocations.Ex vivo cells exhibited greater prevalence of deletions and terminal deletions,whereas in vitro cells displayed more ring aberrations and Robertsonian translocations.In conclusion,we successfully characterized cancer cells from a syngeneic mouse model of breast cancer in terms of rare CSC proportion and a variety of chromosomal aberrations,which is useful for understanding tumor traits associated with cancer development and therapeutic action.The data act as a valuable resource for other studies using the 4T1 BALB/c model.
文摘In this paper,we present a circuit model of single-quantum-well InGaN/GaN light-emitting diodes based on the standard rate equations.Two rate equations describe carrier transport processes occurring in sep-arate confinement heterostructure and quantum well respectively,and the third equation describes the varied photons in quantum well.By using the presented model,impacts of quantum well thickness on the static and dynamic performances are investigated.Simulated results show that LED with 4 nm well exhibits better lightcurrent(L-I)performance,but LED with 3 nm well presents wider 3 dB modulation bandwidth.It reveals that high carrier density in quantum well is detrimental to the static performance,but beneficial to the dynamic performance.
文摘Background 3D botanical tree reconstruction from a single image plays a vital role in the field of computer graphics.However,accurately capturing the intricate branching patterns and detailed morphologies of trees remains a challenge.Methods In this study,we proposed a novel approach for single-image tree reconstruction using a conditional generative adversarial network to infer the 3D skeleton of a tree in the form of a 2D skeleton depth map.Based on the 2D skeleton depth map,a corresponding branching structure(3D skeleton)that inherits the tree shape in the input image and leaves can be generated using a procedural modeling technique.Result Experimental results show that the proposed method accurately reconstructs diverse tree structures across species.Both quantitative and qualitative evaluations demonstrate improved skeleton completeness,branching accuracy,and visual realism over baseline methods,while requiring no user input.Conclusions Our proposed approach for generating lifelike 3D tree models from a single image with no user input shows its proficiency in achieving efficient and reliable reconstruction.These results showcase the capability of the proposed model to recreate complex tree architectures while capturing their visual authenticity.
基金financial support of the National Natural Science Foundation of China(32102016)the Taishan Industrial Experts Program,Beijing Postdoctoral Research Foundation(2323ZZ122).
文摘The increase in human population has led to imminent pressures to develop new edible proteins with decreased environmental footprints.The most promising approach involves the production of single cell protein(SCP)from yeasts,which have been utilized in a wide variety of foods for thousands of years.In this study,102 yeast strains isolated from traditional fermented pork(Nanx Wudl)were investigated for their potential as SCP producer for the first time.Based on preliminary screening,Saccharomyces cerevisiae Y70 and Candida parapsilosis H5Y13,both showing high protein content and excellent growth capability,were selected for further analysis via 4D-DIA proteomics technology.Proteomic analysis indicated that the oxidative metabolism pathways,including TCA cycle,oxidative phosphorylation and pentose phosphate pathway,may have a significant impact on global protein synthesis and production.This study provides useful information for selecting SCP-producing yeast from Chinese fermented meat products and contribute to a deeper understanding of the underlying metabolic mechanisms behind global protein synthesis in yeast.Furthermore,these findings also provide potential molecular targets for genetic engineering modifications in yeast,aimed at constructing highly efficient cell factories for protein production.
基金supported by the National Natural Science Foundation of China(Grant No.11704301)the Natural Science Basic Research Plan in Shaanxi Province of China(Program No.2022JM212)supported by the Ministry of Science and Higher Education of the Russian Federation(FSEG-2023-0016).
文摘High-performance lead-free piezoelectric single crystals are urgently needed for next-generation actuators and transducers.In this study,we reveal that a compositionally driven tetragonal-pseudocubic(T-PC)phase boundary,in conjunction with an octahedral order-disorder tilting transition,significantly enhances the piezoelectric response in Nb^(5+)-substitution(Bi_(0.48)Na_(0.425)K_(0.055)Ba_(0.04))(Ti_(0.98)Nb_(0.02))O_(3)(BNKBT-2Nb)single crystals.The crystal achieves an outstanding piezoelectric coefficient of d33=662 pC/N at room temperature.In situ X-ray diffraction confirms an electric field-induced transition from the PC to T phase.Atomic-resolution HADDF-STEM analysis reveals an increase in the c/a ratio(c/a>1.01)on the local scale and ordered octahe-dral tilting of the a^(0)a^(0)c+type driven by the poling field.The single crystals exhibit excellent piezoelectric per-formance over a broad temperature range,achieving a peak d_(33) of 920 pC/N at approximately 92℃.Furthermore,the polar states exhibit a pronounced frequency dependence near the depolarization temperature.These findings provide critical insight into the structure-property relationship and offer a promising pathway for designing advanced lead-free piezoelectric crystals for functional electromechanical applications.
文摘Pediatric cancers are particularly significant due to their uncommon occurrence in children,driven by a variety of underlying factors.Because of their distinct molecular and genetic makeup,which makes early detection challenging,they are linked to problems.Diagnostic methods like imaging and tissue biopsy are only effective when the tumor has reached a size that can be identified.The liquid biopsy technique,the least intrusive and most convenient diagnostic method,is the subject of this review.It focuses on the significance of single cell analysis in examining uncommon cancer types.The many biomarkers found in bodily fluids and the cancer types they are linked to in children have been assessed,as has the potential route towards early detection and cancer recurrence forecasting.Combining the single cell liquid biopsy with the newest technologies,such as computational and multi-omics approaches,which have improved the efficiency of processing massive and unique genetic data,appears promising.This article discusses on a number of case reports for uncommon pediatric malignancies,such as Neuroblastoma,Medulloblastoma,Wilms Tumor,Rhabdomyosarcoma,Ewing Sarcoma,and Retinoblastoma,as well as their liquid biopsy profiles.Furthermore,the findings raise ethical questions regarding the therapeutic application of the technology as well as possible difficulties related to clinical translation.The likelihood that this single cell liquid biopsy will be clinically validated and eventually used as a routine diagnostic tool for uncommon pediatric cancers will rise with the realistic approach to sensitivity monitoring,specificity upgrading,and optimization.
文摘Sliver defects are a group of low-to-medium angle misoriented grains in Ni-based single crystal superalloys that have received more attention in recent years.Occurrence of these defects can negatively affect the mechanical properties of single crystal components.Therefore,studying the mechanisms of sliver formation and its effects on the final properties of alloys is of great importance.In this article,recent studies on the sliver defects were reviewed.Accordingly,the mechanisms of sliver formation as well as factors contributing to sliver initiation were studied.Additionally,effects of slivers on the mechanical properties of single crystal superalloys were discussed.Dendrite deformation and dendrite fracture are the main mechanisms for the sliver formation.This is a consequence of local stress concentration on dendrites during solidification.Therefore,locations such as inclusions,pores,geometrically complex areas,mould walls,freckle channels,etc.can be considered as the potential factors that promote the sliver initiation.Sliver formation significantly degrades the creep life of single-crystal superalloys.Studies have shown that when crystallographic misorientation exceeds approximately15°,creep life can be reduced by up to 47%.Despite the absence of a standardized criterion for predicting or preventing sliver initiation and propagation,their occurrence can be minimized through optimization of solidification parameters,careful grain selection,proper casting geometry design,and rigorous control of material purity and equipment conditions.
基金supported by the National Natural Science Foundation of China(Nos.22406081,22276086,22306086)the Natural Science Foundation of Jiangxi Province(No.20232BAB213029),all of which are greatly acknowledged by the authors.
文摘Fenton-like technology based on peroxymonosulfate activation has shown great potential in refractory organics degradation.In this work,single Fe atom catalysts were synthesized through facile ball milling and exhibited very high performance in peroxymonosulfate activation.The Fe single-atom filled an N vacancy on the triazine ring edge of C_(3)N_(4),as confirmed through X-ray absorption fine structure,density functional calculation and elec-tron paramagnetic resonance.The SAFe_(0.4)–C_(3)N_(4)/PMS system could completely remove phenol(20 mg/L)within 10 min and its first-order kinetic constant was 12.3 times that of the Fe_(3)O_(4)/PMS system.Under different ini-tial pH levels and in various anionic environments,SAFe_(0.4)–C_(3)N_(4) still demonstrated excellent catalytic activity,achieving a removal rate of over 90%for phenol within 12 min.In addition,SAFe_(0.4)–C_(3)N_(4) exhibited outstanding selectivity in reaction systems with different pollutants,showing excellent degradation effects on electron-rich pollutants only.Hydroxyl radicals(•OH),singlet oxygen(1O_(2))and high-valent iron oxide(Fe(Ⅳ)=O)were de-tected in the SAFe_(0.4)–C_(3)N_(4)/PMS system through free radical capture experiments.Further experiments on the quenching of active species and a methyl phenyl sulfoxide probe confirmed that 1O_(2) and Fe(Ⅳ)=O played dom-inant roles.Additionally,the change in the current response after adding PMS and phenol in succession proved that a direct electron transfer path between organic matter and the catalyst surface was unlikely to exist in the SAFe_(0.4)–C_(3)N_(4)/PMS/Phenol degradation system.This study provides a new demonstration of the catalytic mech-anism of single-atom catalysts.
基金Supported by National Natural Science Foundation of China(Grant Nos.52475433,52305453)Hebei Provincial Natural Science Foundation(Grant No.E2022501004)+1 种基金the Fundamental Research Funds for the Central Universities(Grant No.2023GFYD002)Shijiazhuang Municipal Science and Technology Plan Project(Grant No.241790747A).
文摘Nickel-based single-crystal superalloy DD98M is widely used in high-temperature components such as aero-engines and gas turbines.Since it has only one crystal grain,the theory of slip deformation along the grain boundary of polycrystalline material is not suitable for the machining of a single crystal part.Therefore,micro-drilling of nickel-based single crystal superalloy still faces problems such as unclear cutting formation me-chanism and unclear surface/subsurface damage mechanism.In this paper,the formation mechanism and morphological characteristics of chips and burrs were studied by a single-factor experiment,and the plastic deformation rule and damage mechanism were investigated,combined with the changes of subsurface structure and grain type.Finally,the influence of the law and reason of tool wear condition on the hole wall and the drilled subsurface is analyzed.The experimental results indicate that drill chips mainly exhibit three morphologies.Their free surfaces feature a serrated appearance,while the contact surfaces are smooth.The entrance burrs are mainly flanging burrs.With the increase of spindle speed,the burr height decreases from 49.38 to 9.39μm.As the feed speed increases,the burr height increases from 6.50 to 63.87μm.The drilled subsurface can be divided into a white layer region,a plastic deformation region,and the matrix according to the microstructural change.As the depth from the machined surface increases,the degree of plastic deformation of the material decreases,the grain size gradually reduces,and the dislocation density decreases.Stacking fault and twinning mostly occur in the high-plastic deformation region,and recrystallization occurs on the machined surface.As the drilling length increases,the degree of tool wear increases,and the adhesion and ablation area on the hole wall surface increase.Moreover,the thickness of the white layer increases from 0 to 8.75μm,and the thickness of the plastic deformation layer increases from 1.28 to 11.31μm.The study has significant theoretical and practical implications for the efficient and low-damage machining of micro-holes in the nickel-based single crystal superalloy.
基金financially supported by the National Science and Technology Major Project of China(No.2019-VII-0019-0161 and No.2019-VII-0004-0144)the National Natural Science Foundation of China(No.92360302)the Shandong Provincial Natural Science Foundation of China(No.ZR2021QE103)。
文摘Turbine blades,due to their intricate geometry,are exposed to multiaxial stresses during operation.Consequently,it is imperative to examine the anisotropy of their stress-rupture behavior across various testing scenarios,particularly under high-temperature conditions.Stress-rupture behavior of a Ni-based single crystal superalloy was investigated under a load varying from 100 MPa to 137 MPa at 1,100℃ for both[001]-and[111]-orientated specimens.Results demonstrate that the rupture behavior of[111]-orientated specimens exhibits obviously higher sensitive to applied stress compared to[001]-orientated specimens.This difference is primarily attributed to the orientation dependentγ'coarsening behavior and distinct dislocation interactions atγ/γ'interfaces.In[001]-oriented specimens,plate-likeγ/γ'rafts rapidly form alongside well-developed interfacial dislocation networks,where theγ/γ'misfit stress dominates the microstructural evolution.In contrast,the[111]-orientated specimens exhibit retained,coarsenedγ'precipitates embedded within theγmatrix,accompanied by poorly developed interfacial dislocation networks.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFA1602504)the National Natural Science Foundation of China(Grant Nos.12274040 and U2430208)。
文摘The single electron capture processes in Si^(3,4+)+He collisions have been investigated theoretically employing the two-center atomic orbital close-coupling method in the energy range 0.01-100 keV/u.Total and state-selective electron capture cross sections for the dominant and subdominant reaction channels are calculated and compared with the available experimental and theoretical data.For the total charge transfer cross sections,the present results show better agreements with the available experimental data than the other theoretical ones in the overlapping energy region for both collision systems.For the state-selective cross sections,the present results for 3s and 3p states are in general agreement with the previous MOCC results in the low energy region for both collision systems.Furthermore,the cross sections for electron captured to the 3d,4l and 5l(l=0,1,...,n-1)states of Si^(2+)and Si^(3+)ions are first provided in a broad energy region in our work.These results are useful for the investigations in astrophysics.The datasets presented in this paper,including the total and state-selective electron capture cross sections of Si^(3,4+)+He collisions in 0.01-100 ke V/u,are openly available at https://doi.org/10.57760/sciencedb.j00113.00257.
基金financial support provided by the National Natural Science Foundation of China(Grant No.12302472)the Science and Technology Support Program of Jiangsu Province(Grant No.BK20230874)+2 种基金the Aeronautical Science Fund(ASF)(Grant No.2023Z057052005)the Research Fund of State Key Laboratory of Mechanics and Control for Aerospace Structures(Nanjing University of Aeronautics and Astronautics)(Grant No.MCAS-I-0124G02)the funding received from Jiangsu Hanvo Safety Product Co.,Ltd。
文摘High-performance fiber fabrics and composites experienced transverse compression deformation at ultrahigh strain rates near the impact point when subjected to high-velocity impacts,which significantly affected their ballistic limits.In this paper,a fiber-scale experimental method for characterizing ultrahigh strain-rate transverse compression behavior was proposed.To begin with,in order to measure the extremely low stress and strain in small specimens,the conventional Hopkinson bar was reduced to the hundred-micron scale,thereby achieving wave impedance matching with single fibers.In addition,tangential and normal laser Doppler velocimetry(LDV)methods were employed to realize non-contact,high-precision,and high-speed axial velocity measurements of micron-scale incident and transmission bars,respectively.Meanwhile,a microscopic observation system was used to facilitate the installation of miniature fiber samples.The experimental setup and procedures were introduced,and the system accuracy was verified through sample-free loading tests based on one-dimensional stress wave propagation theory.Dynamic compression experiments on Graphene-UHMWPE fibers were carried out,followed by post-compression microstructural characterization via scanning electron microscopy(SEM).Results demonstrated that successful mechanical characterization was achieved at strain rates exceeding 105,an order of magnitude higher than the previously reported maximum rates.Furthermore,during the loading process,the fibers underwent uniform compression deformation while exhibiting pronounced strain-rate effects.This method offers a novel approach for dynamic mechanical characterization of microscale single fibers,enabling the development of comprehensive strain-ratedependent material models to guide the design of advanced composites and high-performance fibers.
基金Supported by the National Natural Science Foundation of China(12261050)Science and Technology Project of Department of Education of Jiangxi Province(GJJ2201612 and GJJ211027)Natural Science Foundation of Jiangxi Province of China(20212BAB202021)。
文摘In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.
基金supported by the Jiangsu Province Traditional Chinese Medicine Technology Development Plan Project,Nos.MS2023113(to JC),MS2022090Young and Middle-aged Academic Leaders of Jiangsu Qing-Lan Project(to GL).
文摘Unlike mammals,zebrafish possess a remarkable ability to regenerate their spinal cord after injury,making them an ideal vertebrate model for studying regeneration.While previous research has identified key cell types involved in this process,the underlying molecular and cellular mechanisms remain largely unexplored.In this study,we used single-cell RNA sequencing to profile distinct cell populations at different stages of spinal cord injury in zebrafish.Our analysis revealed that multiple subpopulations of neurons showed persistent activation of genes associated with axonal regeneration post injury,while molecular signals promoting growth cone collapse were inhibited.Radial glial cells exhibited significant proliferation and differentiation potential post injury,indicating their intrinsic roles in promoting neurogenesis and axonal regeneration,respectively.Additionally,we found that inflammatory factors rapidly decreased in the early stages following spinal cord injury,creating a microenvironment permissive for tissue repair and regeneration.Furthermore,oligodendrocytes lost maturity markers while exhibiting increased proliferation following injury.These findings demonstrated that the rapid and orderly regulation of inflammation,as well as the efficient proliferation and redifferentiation of new neurons and glial cells,enabled zebrafish to reconstruct the spinal cord.This research provides new insights into the cellular transitions and molecular programs that drive spinal cord regeneration,offering promising avenues for future research and therapeutic strategies.
基金supported by the National Key Research and Development Program of China(Grant Nos.2024YFA1611100,2023YFA1406100,and 2018YFA0704201)the Systematic Fundamental Research Program Leveraging Major Scientific and Technological Infrastructure,Chinese Academy of Sciences(Grant No.JZHKYPT-2021-08)+1 种基金the National Natural Science Foundation of China(Grant Nos.11704385,11874359,and 12274444)the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(Grant No.XDB25000000)。
文摘Temperature-dependent resistivity,upper critical field H_(c2)and its anisotropy in overdoped superconducting Ba_(1-x)K_x Fe_2As_2(x=0.6-1)single crystals have been measured in steady magnetic fields up to 44 T and low temperatures down to 0.4 K.Analysis using both the quadratic term and power-law fitting demonstrates that the in-plane resistivityρ_(ab)(T)progressively approaches the Fermi-liquid T~2behavior with increasing K doping and reaches a saturation plateau at x≈0.8.The temperature dependence of both H_(c2)^(ab)and H^(c)_(c2)follows the Werthamer-Helfand-Hohenberg model,incorporating orbital and spin paramagnetic effects.For x≤0.8,the orbital effect dominates for H ab,while the Pauli paramagnetic effect prevails for H c.For x>0.8,the Pauli paramagnetic effect becomes dominant in both crystallographic directions.The anisotropy of H_(c2)(0)exhibits a discontinuity in its dependence on K doping concentration with a significant enhancement at x=0.8 and a maximum at x=0.9.These experimental results indicate that the electron correlation effect is enhanced in the heavily overdoped Ba_(1-x)K_(x)Fe_(2)As_(2)system where the underlying symmetries are broken due to the Fermi surface reconstruction before x=0.9.
文摘Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other diseases often observed in a patient’s history in addition to their AD diagnosis,make deciphering the molecular mechanisms that underlie AD,even more important.Large datasets of single-cell RNA sequencing,single-nucleus RNA-sequencing(snRNA-seq),and spatial transcriptomics(ST)have become essential in guiding and supporting new investigations into the cellular and regional susceptibility of AD.However,with unique technology,software,and larger databases emerging;a lack of integration of these data can contribute to ineffective use of valuable knowledge.Importantly,there was no specialized database that concentrates on ST in AD that offers comprehensive differential analyses under various conditions,such as sex-specific,region-specific,and comparisons between AD and control groups until the new Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)database(Wang et al.,2024)was introduced to meet the scientific community’s growing demand for comprehensive,integrated,and accessible data analysis.
基金supported by the National Natural Science Foundation of China (Grant Nos.12494604,12393834,12393831,62274014,6223501662335015)the National Key R&D Program of China (Grant No.2024YFA1208900)。
文摘The development of quantum materials for single-photon emission is crucial for the advancement of quantum information technology.Although significant advancements have been witnessed in recent years for single-photon sources in the near-infrared band(λ∼700–1000 nm),several challenges have yet to be addressed for ideal single-photon emission at the telecommunication band.In this study,we present a droplet-epitaxy strategy for O-band to C-band single-photon source-based semiconductor quantum dots(QDs)using metal-organic vaporphase epitaxy(MOVPE).By investigating the growth conditions of the epitaxial process,we have successfully synthesized InAs/InP QDs with narrow emission lines spanning a broad spectral range of λ∼1200–1600 nm.The morphological and optical properties of the samples were characterized using atomic force microscopy and microphotoluminescence spectroscopy.The recorded single-photon purity of a plain QD structure reaches g^((2))(0)=0.16,with a radiative recombination lifetime as short as 1.5 ns.This work provides a crucial platform for future research on integrated microcavity enhancement techniques and coupled QDs with other quantum photonics in the telecom bands,offering significant prospects for quantum network applications.
文摘Accurate prediction of wind energy plays a vital role in maintaining grid stability and supporting the broader shift toward renewable energy systems.Nevertheless,the inherently variable nature of wind and the intricacy of high-dimensional datasets pose major obstacles to reliable forecasting.To address these difficulties,this study presents an innovative hybrid method for short-term wind power prediction by combining a Long Short-Term Memory(LSTM)network with a Single Candidate Optimizer(SCO)algorithm.In contrast to conventional techniques that rely on random parameter initialization,the proposed LSTM-SCO framework leverages the distinctive capability of SCO to work with a single candidate solution,thereby substantially reducing the computational overhead compared to traditional population-based metaheuristics.The performance of the model was benchmarked against various classical and deep learning models across datasets from three geographically diverse sites,using multiple evaluation metrics.Experimental findings demonstrate that the SCO-optimized model enhances prediction accuracy by up to 12.5%over standard LSTM implementations.
基金Supported by Government Assignment,No.1023022600020-6RSF Grant,No.24-15-00549Ministry of Science and Higher Education of the Russian Federation within the Framework of State Support for the Creation and Development of World-Class Research Center,No.075-15-2022-304.
文摘BACKGROUND Ischemic heart disease(IHD)impacts the quality of life and has the highest mortality rate of cardiovascular diseases globally.AIM To compare variations in the parameters of the single-lead electrocardiogram(ECG)during resting conditions and physical exertion in individuals diagnosed with IHD and those without the condition using vasodilator-induced stress computed tomography(CT)myocardial perfusion imaging as the diagnostic reference standard.METHODS This single center observational study included 80 participants.The participants were aged≥40 years and given an informed written consent to participate in the study.Both groups,G1(n=31)with and G2(n=49)without post stress induced myocardial perfusion defect,passed cardiologist consultation,anthropometric measurements,blood pressure and pulse rate measurement,echocardiography,cardio-ankle vascular index,bicycle ergometry,recording 3-min single-lead ECG(Cardio-Qvark)before and just after bicycle ergometry followed by performing CT myocardial perfusion.The LASSO regression with nested cross-validation was used to find the association between Cardio-Qvark parameters and the existence of the perfusion defect.Statistical processing was performed with the R programming language v4.2,Python v.3.10[^R],and Statistica 12 program.RESULTS Bicycle ergometry yielded an area under the receiver operating characteristic curve of 50.7%[95%confidence interval(CI):0.388-0.625],specificity of 53.1%(95%CI:0.392-0.673),and sensitivity of 48.4%(95%CI:0.306-0.657).In contrast,the Cardio-Qvark test performed notably better with an area under the receiver operating characteristic curve of 67%(95%CI:0.530-0.801),specificity of 75.5%(95%CI:0.628-0.88),and sensitivity of 51.6%(95%CI:0.333-0.695).CONCLUSION The single-lead ECG has a relatively higher diagnostic accuracy compared with bicycle ergometry by using machine learning models,but the difference was not statistically significant.However,further investigations are required to uncover the hidden capabilities of single-lead ECG in IHD diagnosis.
基金the Indian Council of Medical Research(No.3/1/2(22)/Env/2021-NCD-II)Department of science and technology,India(CRG/2021/000227)for funding this research.
文摘Many studies have shown the negative relationship between long term exposure to PM_(2.5)and cardiac dysfunction.Recently,studies have shown that even a single exposure of PM_(2.5)from air sample in permissible range can induce very mild cardiac pathological changes.In the present study,we revisited the toxic effect of PM_(2.5)on rat heart by adopting single and multiple exposure durations.FemaleWistar ratswere exposed to PM_(2.5)at a concentration of 250μg/m3 daily for 3 hr for single(1 day)and multiple(7,14,21 days)durations.The major pathological changes noted in 21 days exposed myocardium comprised of an elevated ST segment(the segment between the S wave and the T wave),development of cardiac fibrosis,hypertrophy,cardiac injury,tissue inflammation and declined cardiac function.With 14 days exposed heart,the electrocardiograms(ECG),data showed insignificantly declined heart rate and an increased QT(the time from the start of the Q wave to the end of the T wave)interval along with mild fibrosis,hypertrophy and lesser number of TUNEL positive cells.On the other hand,single-and 7-days exposure to PM_(2.5)did not impart any significant changes in the myocardium.To determine the reversibility potential of PM_(2.5)induced cardiotoxicity,a washout period of 24 hours was adopted and all observed changes in the myocardium were reversed till day 7,but not in 14-and 21-days exposed samples.Based on the above findings we concluded that PM_(2.5)associated cardiac dysfunction is the cumulative outcome of ineffective cardiac adaptive and repair process that accumulate additively over the time due to prolonged exposure durations.
