The single ion channel signal is an ionic current that can be recorded by the patch clamp technique. Hidden Markov model (HMM) algorithm has been used to convert the low signal noise ratio (SNR) noisy recording into a...The single ion channel signal is an ionic current that can be recorded by the patch clamp technique. Hidden Markov model (HMM) algorithm has been used to convert the low signal noise ratio (SNR) noisy recording into an idealized quantal one in the case of white background noise. The traditional HMM algorithm is extended and adapted to the colored background noise. A new algorithm called EHMM (Extended HMM) algorithm is proposed, and mainly validated by simulation. Results show that it’s effective.展开更多
Many kinds of channel currents are especially weak and the background noise dominates in the patch clamp recordings. This makes the threshold detection fail during estimating of the transition probabilities. So direct...Many kinds of channel currents are especially weak and the background noise dominates in the patch clamp recordings. This makes the threshold detection fail during estimating of the transition probabilities. So direct fitting of the patch clamp recording, not of the histogram coming from the recordings, is a desirable way to estimate the transition probabilities. Iterative batch EM algorithm based on hidden markov model has been used in this field but which has the "curse of dimensionality" and besides cant keep tracking the varying of the parameters. A new on line sequential iterative one is proposed here, which needs fewer computational efforts and can adaptively keep tracking the varying of parameters. Simulations suggest its robust, effective and convenient.展开更多
针对频率选择性衰落信道下2发1收STBC-SC-FDE系统收发两端的信号编码与处理结构,应用系统的频率域输入-输出模型,设计了一种最小二乘信道频率响应(Channel frequency response,CFR)估计算法。对算法均方误差的分析表明,采用Chu序列作为...针对频率选择性衰落信道下2发1收STBC-SC-FDE系统收发两端的信号编码与处理结构,应用系统的频率域输入-输出模型,设计了一种最小二乘信道频率响应(Channel frequency response,CFR)估计算法。对算法均方误差的分析表明,采用Chu序列作为最优训练序列不仅能够实现CFR估计的最小均方误差,而且能保证系统具有比较低的峰均功率比(Peak-to-average power ratio,PA/PR)。该算法相比那些先估计信道时域响应(Channel impulse response,CIR)再转换为CFR的方法能够节省更多的计算资源。最后Monte Carlo仿真验证了该算法的性能。展开更多
文摘The single ion channel signal is an ionic current that can be recorded by the patch clamp technique. Hidden Markov model (HMM) algorithm has been used to convert the low signal noise ratio (SNR) noisy recording into an idealized quantal one in the case of white background noise. The traditional HMM algorithm is extended and adapted to the colored background noise. A new algorithm called EHMM (Extended HMM) algorithm is proposed, and mainly validated by simulation. Results show that it’s effective.
文摘Many kinds of channel currents are especially weak and the background noise dominates in the patch clamp recordings. This makes the threshold detection fail during estimating of the transition probabilities. So direct fitting of the patch clamp recording, not of the histogram coming from the recordings, is a desirable way to estimate the transition probabilities. Iterative batch EM algorithm based on hidden markov model has been used in this field but which has the "curse of dimensionality" and besides cant keep tracking the varying of the parameters. A new on line sequential iterative one is proposed here, which needs fewer computational efforts and can adaptively keep tracking the varying of parameters. Simulations suggest its robust, effective and convenient.
基金The National Natural Science Foundation of Shandong Province(No.62071276)the Key Research and Development Project of the Ministry of Science and Technology(No.2020YFC0833203).
文摘针对频率选择性衰落信道下2发1收STBC-SC-FDE系统收发两端的信号编码与处理结构,应用系统的频率域输入-输出模型,设计了一种最小二乘信道频率响应(Channel frequency response,CFR)估计算法。对算法均方误差的分析表明,采用Chu序列作为最优训练序列不仅能够实现CFR估计的最小均方误差,而且能保证系统具有比较低的峰均功率比(Peak-to-average power ratio,PA/PR)。该算法相比那些先估计信道时域响应(Channel impulse response,CIR)再转换为CFR的方法能够节省更多的计算资源。最后Monte Carlo仿真验证了该算法的性能。
