Existing papers on human capital and growth in China has been using single equation estimations.This might cause a simultaneity bias if a two-way causality between the two variables exists.In this paper,the author per...Existing papers on human capital and growth in China has been using single equation estimations.This might cause a simultaneity bias if a two-way causality between the two variables exists.In this paper,the author performs vector autoregressive estimations using panel data on the number of graduates at each level of education as a proxy for human capital in China during 1991-2005.The results show that investment in human capital increases output per worker at all three levels of education.Regarding the effects of output per worker on the accumulation of human capital,the author finds mixed results with the primary-school graduates'benefits the most from increases in per capita output.展开更多
With advances in solid organ transplantation,the option of combined kidney with other solid organ transplantation is an enticing option for patients with advanced kidney disease and concomitant other solid organ failu...With advances in solid organ transplantation,the option of combined kidney with other solid organ transplantation is an enticing option for patients with advanced kidney disease and concomitant other solid organ failure.Kidney allograft dysfunction is well known to be associated with increased adverse outcomes post solitary kidney transplant however,outcomes for patients and the kidney allograft are somewhat understudied in the setting of kidney transplantation when combined with other solid organ transplantation such as in a simultaneous liverkidney transplant.We will provide an overview of the current literature available on kidney allograft clinical outcome measures in combined solid organ transplant recipients such as delayed kidney allograft function,kidney allograft rejection,kidney allograft and patient survival metrics and how they compare to patients with kidney transplants alone.Worse kidney allograft survival outcomes were noted in most combined other organ with kidney transplantation(liver-kidney,heart-kidney,and lung-kidney)due to comorbidities attributed to non-renal organ dysfunction whereas improved kidney allograft survival outcomes were noted for pancreas-kidney transplantation.展开更多
Diabetes is a widespread disease affecting millions of people,making it one of the leading causes of death in the world.It is a leading cause of cardiovascular disease and end-stage renal disease.Despite advancements ...Diabetes is a widespread disease affecting millions of people,making it one of the leading causes of death in the world.It is a leading cause of cardiovascular disease and end-stage renal disease.Despite advancements in treatment,including insulin therapy and glucose monitoring devices,diabetes continues to significantly impact quality of life and current modalities do not reverse the end-organ damage associated with its progression.While traditionally indicated for type 1 diabetes,recent clinical practice refinements have made pancreas transplants available to select type 2 diabetics meeting specific criteria.These transplants are usually a part of a simultaneous kidney-pancreas transplant.However,although less frequently performed,transplants of pancreas alone or pancreas after kidney transplant are still available.For selected diabetic patients,pancreas transplants offer significant survival benefits and the improvement of cardiovascular and metabolic complications;however,they are not without risks.Complications such as bleeding,vascular thrombosis,infection,organ leak,and rejection are possible.Another challenge to pancreas transplantation is the decreasing number of procedures being performed due to decline in the volume of available highquality allografts and resource constraints of transplant centers.Advancements in monitoring and treatment of diabetes are contributing to the decline in pancreas transplants nowadays.展开更多
The integration of surface filtration and catalytic decomposition functions in catalytic bags enables the synergistic removal of multiple pollutants(such as dust,nitrogen oxide,acid gases,and dioxins)in a single react...The integration of surface filtration and catalytic decomposition functions in catalytic bags enables the synergistic removal of multiple pollutants(such as dust,nitrogen oxide,acid gases,and dioxins)in a single reactor,thus effectively reducing the cost and operational difficulties associated with flue gas treatment.In this study,Mn-Ce-Sm-Sn(MCSS)catalysts were prepared and loaded onto hightemperature resistant polyimide(P84)filter through ultrasonic impregnation to create composite catalytic filter.The results demonstrate that the NO conversion rates of the composite catalytic filter consistently achieve above 95%within the temperature range of 160-260℃,with a chlorobenzene T_(90)value of 230℃.The ultrasonic impregnation method effectively loaded the catalyst onto the filter,ensuring high dispersion both on the surface and inside the filter.This increased exposure of catalyst active sites enhances the catalytic activity of the composite catalytic filter.Additionally,increasing the catalyst loading leads to a gradual decrease in permeability,an increase in pressure drops and the long residence time of the flue gas,thereby improving catalytic activity.Compared to ordinary impregnation methods,ultrasonic impregnation improves the bonding strength between the catalyst and filter,as well as the permeability of the composite catalytic filter under the same loading conditions.Overall,this study presents a novel approach to prepare composite catalytic filter for the simultaneous removal of NO and chlorobenzene at low temperatures.展开更多
Implementing quantum wireless multi-hop network communication is essential to improve the global quantum network system. In this paper, we employ eight-level GHZ states as quantum channels to realize multi-hop quantum...Implementing quantum wireless multi-hop network communication is essential to improve the global quantum network system. In this paper, we employ eight-level GHZ states as quantum channels to realize multi-hop quantum communication, and utilize the logical relationship between the measurements of each node to derive the unitary operation performed by the end node. The hierarchical simultaneous entanglement switching(HSES) method is adopted, resulting in a significant reduction in the consumption of classical information compared to multi-hop quantum teleportation(QT)based on general simultaneous entanglement switching(SES). In addition, the proposed protocol is simulated on the IBM Quantum Experiment platform(IBM QE). Then, the data obtained from the experiment are analyzed using quantum state tomography, which verifies the protocol's good fidelity and accuracy. Finally, by calculating fidelity, we analyze the impact of four different types of noise(phase-damping, amplitude-damping, phase-flip and bit-flip) in this protocol.展开更多
Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental factors.These vehicles are crucial in various fields,including environ...Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental factors.These vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant challenge.To address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data registration.Specifically,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less efficient.Meanwhile,visual texture information complements LiDAR-Visual localization by providing additional contextual details.By incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of localization.This approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.展开更多
The accuracy of thermal analysis measurements is critical to analyze material properties correctly,making the improvement of measurement precision and proper uncertainty analysis of test results absolutely essential.A...The accuracy of thermal analysis measurements is critical to analyze material properties correctly,making the improvement of measurement precision and proper uncertainty analysis of test results absolutely essential.As a primary thermal analysis instrument,the simultaneous thermal analyzer(STA)has unique advantages,which combines the functionalities of thermogravimetric(TG)analyzersand differential scanning calorimeters(DSC).However,the absence of standard quality control procedures has resulted in poor measurement reproducibility,low accuracy,and inadequate traceability of analytical results.This study utilized a multi-point temperature calibration method based on national certified reference materials to reduce instrument temperature indication errors.On this basis,we innovatively established a comprehensive quality control system encompassing laboratory environmental control,standard method selection,instrument performance verification,reference material traceability,and uncertainty analysis,thereby achieving standardized operational procedures for thermal analysis measurement.Taking the"determination of initial melting temperature of unknown substances"as a representative case study,a component resolution model for thermal analysis test uncertainty was developed.Through systematic analysis of both the reference material-introduced component and measurement repeatability component,complete traceability of test results was achieved.This approach ensures data validity and enhances the accuracy of test results.This provides crucial technical support and practical reference for the standardization of thermal analysis measurement procedure and assessment of result reliability.展开更多
Fenton/Fenton-like reactions have gained popularity for their remarkable proficiency in decomposing organic pollutants,especially when enhanced by reductants addition for accel-erating the Fe2+regeneration.Nevertheles...Fenton/Fenton-like reactions have gained popularity for their remarkable proficiency in decomposing organic pollutants,especially when enhanced by reductants addition for accel-erating the Fe2+regeneration.Nevertheless,these works predominantly centered on the formation and utilization of hydroxyl radicals(•OH)in the process,neglecting the evolution of oxidant and reductant due to the difficulty in the simultaneous determination of these two components.By employing the quenching-iodometric method,we could simultaneously determine the concentrations of HSO_(3)-and peroxydisulfate(PDS).This method first employed an excess of peroxymonosulfate(PMS)to effectively quench HSO_(3)-,and then used the iodometric spectrophotometry to simultaneously determine the concentrations of PMS and PDS in the reaction system.Finally,through precise stoichiometric relationships,we could accurately calculate the concentration of HSO_(3)-.Based on this method,we achieved concentration measurements that,upon linear fitting,yielded a correlation coefficient(R^(2))surpassing 0.99,unequivocally affirming the method’s accuracy and trustworthiness.In this work,an innovation approach for determining the concentrations of HSO_(3)-(reductant)and PDS(oxidant)was explored.Additionally,the resilience of the method was verified across different pH levels and in the presence of diverse impurity ions.The results ensured precise concentration measure-ments in the real wastewater.This method was characterized by its simplicity,rapid analysis,and environmental friendliness,offering a newanalytical strategy for the determination of PDS and HSO_(3)-in environmental samples.The method enables more meticulous monitoring of chemical usage in water treatment,facilitating optimized dosing strategies and assessments of reductant-enhanced Fenton or Fenton-like system in water purification.展开更多
Fibers with deformation-triggered responses are essential for smart textiles and wearable electronics.Here,smart core-shell elastomer fibers with a conductive core and a liquid crystal elastomer shell showing simultan...Fibers with deformation-triggered responses are essential for smart textiles and wearable electronics.Here,smart core-shell elastomer fibers with a conductive core and a liquid crystal elastomer shell showing simultaneous resistance and color responses are designed and prepared.The conductive core is consisted of interconnected liquid metal nanodroplets dispersed in a polymer matrix and the elastomer shell is made of cholesteric liquid crystals.When stretched,the fiber resistance increases as the interconnected pathways of liquid metal nanodroplets along the fiber axis become narrower,and the selective reflection color from the fiber surface blueshifts since the cholesteric pitch decreases.The smart elastomer fibers could be woven into smart textiles and respond to various mechanical deformations,including stretching,bending,compression and twisting.The average resistance change is 51%under 100%strain and its variation is smaller than 4%over 500 cycles,showing remarkable fatigue resistance.The simultaneous resistance and color responses to mechanical deformations make the fibers attractive for broad applications,such as flexible electronics.展开更多
Arsenic and cadmium contamination frequently coexist in the real environment.However it remains a challenge for their simultaneous removal due to their distinct physicochemica properties at low cost.To this end,a cost...Arsenic and cadmium contamination frequently coexist in the real environment.However it remains a challenge for their simultaneous removal due to their distinct physicochemica properties at low cost.To this end,a cost-effective magnetic biochar adsorbent (ITBNa800was prepared using biomass waste and iron tailings slag.This composite adsorbent exhibits excellent performance in the simultaneous removal of aqueous As(Ⅴ) and Cd(Ⅱ) even at high concentrations with removal efficiencies of up to 99.98%and 96.04%,respectively.Electro static action,precipitation,and complexation were adsorption mechanisms.As(Ⅴ) and Cd(Ⅱ were synergistic and competitive adsorption.As(Ⅴ) removal was mainly due to physical and chemical adsorption,and 42.40%-58.59%of As(Ⅴ) had been converted to As(Ⅲ ).Cd(Ⅱ) re moval was mainly due to chemical adsorption.Iron oxide and aluminum oxide in ITBNa800were the keys to As(Ⅴ),As(Ⅲ ),and Cd(Ⅱ) adsorption.DFT calculations revealed iron oxide complex As(Ⅴ),As(Ⅲ ),and Cd(Ⅱ) molecular clusters through bidentate binuclear,bidentate binuclear,and monodentate binuclear pathways,respectively.Aluminum oxide complex Cd(Ⅱ) molecular cluster through a bidentate mononuclear pathway.We hope the ITBNa800adsorbent and its involved mechanism could offer inspiration in the simultaneous treat ment of As and Cd pollution.展开更多
Deblending is a data processing procedure used to separate the source interferences of blended seismic data,which are obtained by simultaneous sources with random time delays to reduce the cost of seismic acquisition....Deblending is a data processing procedure used to separate the source interferences of blended seismic data,which are obtained by simultaneous sources with random time delays to reduce the cost of seismic acquisition.There are three types of deblending algorithms,i.e.,filtering-type noise suppression algorithm,inversion-based algorithm and deep-learning based algorithm.We review the merits of these techniques,and propose to use a sparse inversion method for seismic data deblending.Filtering-based deblending approach is applicable to blended data with a low blending fold and simple geometry.Otherwise,it can suffer from signal distortion and noise leakage.At present,the deep learning based deblending methods are still under development and field data applications are limited due to the lack of high-quality training labels.In contrast,the inversion-based deblending approaches have gained industrial acceptance.Our used inversion approach transforms the pseudo-deblended data into the frequency-wavenumber-wavenumher(FKK)domain,and a sparse constraint is imposed for the coherent signal estimation.The estimated signal is used to predict the interference noise for subtraction from the original pseudo-deblended data.Via minimizing the data misfit,the signal can be iteratively updated with a shrinking threshold until the signal and interference are fully separated.The used FKK sparse inversion algorithm is very accurate and efficient compared with other sparse inversion methods,and it is widely applied in field cases.Synthetic example shows that the deblending error is less than 1%in average amplitudes and less than-40 dB in amplitude spectra.We present three field data examples of land,marine OBN(Ocean Bottom Nodes)and streamer acquisitions to demonstrate its successful applications in separating the source interferences efficiently and accurately.展开更多
Heterotrophic denitrification based on polylactic acid(PLAHD)can remove nitrate effectively,but it is expensive and can't remove phosphate.Autotrophic denitrification based on iron sulfide(ISAD)can simultaneously ...Heterotrophic denitrification based on polylactic acid(PLAHD)can remove nitrate effectively,but it is expensive and can't remove phosphate.Autotrophic denitrification based on iron sulfide(ISAD)can simultaneously remove nitrate and phosphate cost-effectively,but its nitrate rate is slow.So,iron sulfide mineral/polylactic acid mixotrophic biofilter(ISPLAB)was constructed to combine advantages of ISAD and PLAHD.ISPLAB achieved nitrogen and phosphorus removal rates of 98.04%and 94.12%,respectively,at a hydraulic retention time(HRT)of 24 h.The study also revealed that controlling molecular weight(MW)of PLA improved the release of soluble organic matter;adding iron sulfide enhanced the hydrolysis of PLA and precipitated PO_(4)^(3-) of Fe^(2+)/Fe^(3+),thereby facilitated simultaneous nitrogen and phosphorus removal.Microbial community analysis resulted that denitrifying bacterias(Phaeodactylibacter and Methylotenera),sulfur-reducing bacterias(Hyphomicrobium),sulfur-oxidizing bacteria(Denitratisoma),iron-reducing bacteria(Romboutsia)and hydrolyzed bacterias(norank_f_norank_o_1-20 and norank_f_Caldilineaceae)coexisted in the ISPLAB system.Organics and iron sulfide drived the denitrification process in ISPLAB.展开更多
Correction to:Nuclear Science and Techniques(2024)36:8 https://doi.org/10.1007/s41365-024-01570-7 In this article the affiliation details for Author Jian Shan were incorrectly given as‘College of Physics and Electron...Correction to:Nuclear Science and Techniques(2024)36:8 https://doi.org/10.1007/s41365-024-01570-7 In this article the affiliation details for Author Jian Shan were incorrectly given as‘College of Physics and Electronic Engi-neering,Hengyang Normal University,Hengyang 421008,China’but should have been‘School of Nuclear Science and Technology,University of South China,Hengyang 421001,China’.The original article has been corrected.展开更多
This study demonstrates the fabrication of mesoporous tungsten trioxide(WO_(3))-decorated flexible polyimide(PI)electrodes for the highly sensitive detection of catechol(CC)and hydroquinone(HQ),two environmental pollu...This study demonstrates the fabrication of mesoporous tungsten trioxide(WO_(3))-decorated flexible polyimide(PI)electrodes for the highly sensitive detection of catechol(CC)and hydroquinone(HQ),two environmental pollutants.Organic-inorganic composite dots are formed on flexible PI electrodes using evaporation-induced self-assembly(EISA)and electrospray methods.The EISA process is induced by a temperature gradient during electrospray,and the heated substrate partially decomposes the organic parts etched by O_(2) plasma,creating mesoporous structures.Differential pulse voltammetry and cyclic voltammetry demonstrate a linear correlation between analyte concentration and the electrochemical response.Computational studies support the spontaneous adsorption of CC and HQ molecules on model WO_(3) surfaces.The proposed sensor shows high sensitivity,a wide linear range,and a low detection limit for both individual and simultaneous determination of CC and HQ.Real sample analysis on river water confirms practical applicability.The WO_(3)-decorated PI electrode presents an efficient and reliable approach for detecting these pollutants,contributing to environmental safety measures.展开更多
BACKGROUND Alveolar and cystic echinococcoses are lethal zoonotic diseases caused by Echinococcus multilocularis and Echinococcus granulosus infections,leading to alveolar echinococcosis(AE)or cystic echinococcosis(CE...BACKGROUND Alveolar and cystic echinococcoses are lethal zoonotic diseases caused by Echinococcus multilocularis and Echinococcus granulosus infections,leading to alveolar echinococcosis(AE)or cystic echinococcosis(CE),respectively.No study has hitherto reported effective treatment approaches for AE or CE with concurrent hepatorenal involvement.AIM To investigate the feasibility and efficacy of simultaneous combined surgery(SCS)as a comprehensive treatment approach for patients with hepatorenal echinococcosis.METHODS Clinical datasets of hepatorenal AE(n=10)and CE(n=11)patients were retrospectively collected and systematically analyzed.The SCS approach was introduced,and surgical outcomes,complications,and prognoses were documented in detail.RESULTS The SCS approach incorporated hybridized techniques,including partial hepatectomy,partial or total nephrectomy,ex vivo liver resection and autotransplantation,and total or subtotal cystectomy with endocystectomy.Radical SCS was achieved in 100%of AE patients and 63.6%of CE patients.All surgeries were completed without intraoperative complications.The short-term complication rate was 28.6%(Clavien-Dindo classification:AE-1 IIIb,3 IIIa;CE-2 II),while the long-term complication rate was 4.8%(Clavien-Dindo classification:AE-1 IIIb).Patients were followed up for a median of 37 months(AE:6-81 months;CE:34-123 months),with no reported deaths or disease relapses.CONCLUSION CS appears to be a feasible and effective treatment method for patients with hepatorenal involvement of AE or CE.It fulfills the management criteria for advanced AE or CE cases,aiming to maximize patient benefits.展开更多
To enable simultaneous transmit and receive(STAR)on the same frequency in a densely deployed space with multi-interference sources,this work proposes a digitally-assisted analog selfinterference cancellation method,wh...To enable simultaneous transmit and receive(STAR)on the same frequency in a densely deployed space with multi-interference sources,this work proposes a digitally-assisted analog selfinterference cancellation method,which can acquire reference signals through flexible wired/wireless switching access.Based on this method,the Minimum Mean Square Error algorithm with known channel state information is derived in detail,determining the upper limit of the cancellation performance,and the Adaptive Dithered Linear Search algorithm for real-time engineering cancellation is given.The correctness of theoretical analysis is verified by the practical self-interference channel measured by a vector network analyzer.Furthermore,we have designed and implemented the corresponding multiinterference cancellation prototype with the digitallyassisted structure,capable of handling multiple interferences(up to three)and supporting a large receive bandwidth of 100 MHz as well as a wide frequency coverage from 30 MHz to 3000 MHz.Prototype test results demonstrate that in the presence of three interferences,when the single interference bandwidth is 0.2/2/20 MHz(corresponding to the receive bandwidth of 2/20/100 MHz),the cancellation performance can reach 46/32/22 dB or more.展开更多
BACKGROUND Detailed data on the relation of post-operative complications with clinical outcomes after simultaneous pancreas-kidney(SPK)transplantation is lacking.AIM To compare Clavien-Dindo classification(CDC)and com...BACKGROUND Detailed data on the relation of post-operative complications with clinical outcomes after simultaneous pancreas-kidney(SPK)transplantation is lacking.AIM To compare Clavien-Dindo classification(CDC)and comprehensive complication index(CCI)in predicting outcomes after SPK.METHODS Data for patients undergoing SPK between 1999-2019 were analyzed.Information on recipients’baseline characteristics,peri-operative management and postoperative complications were collated.Length of hospital stay(LOS)was the primary study outcome,and the associations with CDC and CCI were evaluated using Spearman’s(ρ)correlation coefficients.RESULTS In the study period,data were available for 128 patients(female n=44,34.4%).Sixty-nine patients had at least one complication with the highest CDC grade of I,II,III,and IV in 8(6.3%),22(17.2%),32(25%),and 7(5.5%)patients,respectively. The mean LOS was 21.4 ± 17.7 days. Both classification systems were correlated with LOS, yet CCI was stronger(Spearman’s ρ: 0.694 vs 0.602, P < 0.001). Female patients (P = 0.019) and patients with pre-transplant cardiovascularevents (P = 0.02) had longer LOS. After adjusted multivariable analysis, the link between LOS and both theCDC and CCI remained relevant. CCI had a superior fit compared to CDC (r2 = 0.729 vs r2 = 0.481), with every 10CCI points being associated with a 5.27 day (P < 0.001) increased LOS.CONCLUSIONThis study showed that the CCI was better linked with LOS compared to CDC and might represent a useful scoreto evaluate the overall burden of postoperative complications in patients undergoing SPK.展开更多
This paper addresses the Multi-Vehicle Routing Problem with Time Windows and Simultaneous Pickup and Delivery(MVRPTWSPD),aiming to optimize logistics distribution routes and minimize total costs.A vehicle routing opti...This paper addresses the Multi-Vehicle Routing Problem with Time Windows and Simultaneous Pickup and Delivery(MVRPTWSPD),aiming to optimize logistics distribution routes and minimize total costs.A vehicle routing optimization model is developed based on the operational requirements of the KS Logistics Center,focusing on minimizing vehicle dispatch,loading and unloading,operating,and time window penalty costs.The model incorporates constraints such as vehicle capacity,time windows,and travel distance,and is solved using a genetic algorithm to ensure optimal route planning.Through MATLAB simulations,34 customer points are analyzed,demonstrating that the simultaneous pickup and delivery model reduces total costs by 30.13%,increases vehicle loading rates by 20.04%,and decreases travel distance compared to delivery-only or pickup-only models.The results demonstrate the significant advantages of the simultaneous pickup and delivery mode in reducing logistics costs and improving vehicle utilization,offering valuable insights for enhancing the operational efficiency of the KS Logistics Center.展开更多
DNA repair enzymes are important in the repair of DNA lesions for maintaining the genome stability,and their abnormal expression induced various human cancers.Simultaneous detection of these DNA enzymes could provide ...DNA repair enzymes are important in the repair of DNA lesions for maintaining the genome stability,and their abnormal expression induced various human cancers.Simultaneous detection of these DNA enzymes could provide convincing evidence based on the comparison of the activity of multiple enzymes than on that of single enzyme.Although fluorescence approach has been applied for the simultaneous detection both of DNA repair enzymes,the spectral overlap and multiwavelength excitation severely restrict the number of available fluorophores.Thus,it is difficult to simultaneously detect three enzymes in a single analysis by fluorescence detection.Herein,we developed a method for the simultaneous determination of three DNA repair enzymes including human flap DNA endonuclease 1(FEN1),human alkyladenine DNA glycosylase(hAAG)and uracil DNA glycosylase(UDG)based on the combination of template-free amplification system with capillary electrophoresis-laser induced fluorescence(CE-LIF)detection.The amplification system was adopted to transfer and amplify the enzymatic products into different length DNA fragments which could be separated effectively by CE-LIF without the complicated modification of the capillary inner wall or labeling different tails on signal probes for separation.The method demonstrated a detection limit of 0.07 U/mL(0.08-160 U/mL)for FEN1,2.40 U/mL(2.5-250U/mL)for hAAG and 2.1×10^(-4)U/mL(0.0004-2.5 U/mL)for UDG,the relative standard deviations(RSDs)of peak time and peak area for different analytes were as follows:2.50%-4,37%and 3.24%-7.18%(inter-day);1.37%-2.71%and 1.43%-3.02%(intra-day),4.28%-6.08%and 4.16%-7.57%(column to column),respectively.And it can identify the inhibitor-like drugs,evaluate enzymatic kinetics and achieve the detection of three enzymes in cell extracts,providing a simple and powerful platform for simultaneous detection of more DNA repair enzymes.展开更多
The“First Multidisciplinary Forum on COVID-19,”as one of the pivotal medical forums organized by China during the initial outbreak of the pandemic,garnered significant attention from numerous countries worldwide.Ens...The“First Multidisciplinary Forum on COVID-19,”as one of the pivotal medical forums organized by China during the initial outbreak of the pandemic,garnered significant attention from numerous countries worldwide.Ensuring the seamless execution of the forum’s translation necessitated exceptionally high standards for simultaneous interpreters.This paper,through the lens of the Translation as Adaptation and Selection theory within Eco-Translatology,conducts an analytical study of the live simultaneous interpretation at the First Multidisciplinary Forum on COVID-19.It examines the interpreters’adaptations and selections across multiple dimensions-namely,linguistic,cultural,and communicative-with the aim of elucidating the guiding role and recommendations that Eco-Translatology can offer to simultaneous interpretation.Furthermore,it seeks to provide insights that may enhance the quality of interpreters’oral translations.展开更多
文摘Existing papers on human capital and growth in China has been using single equation estimations.This might cause a simultaneity bias if a two-way causality between the two variables exists.In this paper,the author performs vector autoregressive estimations using panel data on the number of graduates at each level of education as a proxy for human capital in China during 1991-2005.The results show that investment in human capital increases output per worker at all three levels of education.Regarding the effects of output per worker on the accumulation of human capital,the author finds mixed results with the primary-school graduates'benefits the most from increases in per capita output.
文摘With advances in solid organ transplantation,the option of combined kidney with other solid organ transplantation is an enticing option for patients with advanced kidney disease and concomitant other solid organ failure.Kidney allograft dysfunction is well known to be associated with increased adverse outcomes post solitary kidney transplant however,outcomes for patients and the kidney allograft are somewhat understudied in the setting of kidney transplantation when combined with other solid organ transplantation such as in a simultaneous liverkidney transplant.We will provide an overview of the current literature available on kidney allograft clinical outcome measures in combined solid organ transplant recipients such as delayed kidney allograft function,kidney allograft rejection,kidney allograft and patient survival metrics and how they compare to patients with kidney transplants alone.Worse kidney allograft survival outcomes were noted in most combined other organ with kidney transplantation(liver-kidney,heart-kidney,and lung-kidney)due to comorbidities attributed to non-renal organ dysfunction whereas improved kidney allograft survival outcomes were noted for pancreas-kidney transplantation.
文摘Diabetes is a widespread disease affecting millions of people,making it one of the leading causes of death in the world.It is a leading cause of cardiovascular disease and end-stage renal disease.Despite advancements in treatment,including insulin therapy and glucose monitoring devices,diabetes continues to significantly impact quality of life and current modalities do not reverse the end-organ damage associated with its progression.While traditionally indicated for type 1 diabetes,recent clinical practice refinements have made pancreas transplants available to select type 2 diabetics meeting specific criteria.These transplants are usually a part of a simultaneous kidney-pancreas transplant.However,although less frequently performed,transplants of pancreas alone or pancreas after kidney transplant are still available.For selected diabetic patients,pancreas transplants offer significant survival benefits and the improvement of cardiovascular and metabolic complications;however,they are not without risks.Complications such as bleeding,vascular thrombosis,infection,organ leak,and rejection are possible.Another challenge to pancreas transplantation is the decreasing number of procedures being performed due to decline in the volume of available highquality allografts and resource constraints of transplant centers.Advancements in monitoring and treatment of diabetes are contributing to the decline in pancreas transplants nowadays.
基金Project supported by the National Key Research and Development Program of China(2021YFB3500600,2021YFB3500605)Natural Science Foundation of Jiangsu Province(BK20220365)+5 种基金Key R&D Program of Jiangsu Province(BE2022142)Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB610002)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_1419)Science and Technology Plan of Yangzhou(YZ2022030,YZ2023020)the State Key Laboratory of Clean and Efficient Coal-fired Power Generation and Pollution Control(D2022FK098)。
文摘The integration of surface filtration and catalytic decomposition functions in catalytic bags enables the synergistic removal of multiple pollutants(such as dust,nitrogen oxide,acid gases,and dioxins)in a single reactor,thus effectively reducing the cost and operational difficulties associated with flue gas treatment.In this study,Mn-Ce-Sm-Sn(MCSS)catalysts were prepared and loaded onto hightemperature resistant polyimide(P84)filter through ultrasonic impregnation to create composite catalytic filter.The results demonstrate that the NO conversion rates of the composite catalytic filter consistently achieve above 95%within the temperature range of 160-260℃,with a chlorobenzene T_(90)value of 230℃.The ultrasonic impregnation method effectively loaded the catalyst onto the filter,ensuring high dispersion both on the surface and inside the filter.This increased exposure of catalyst active sites enhances the catalytic activity of the composite catalytic filter.Additionally,increasing the catalyst loading leads to a gradual decrease in permeability,an increase in pressure drops and the long residence time of the flue gas,thereby improving catalytic activity.Compared to ordinary impregnation methods,ultrasonic impregnation improves the bonding strength between the catalyst and filter,as well as the permeability of the composite catalytic filter under the same loading conditions.Overall,this study presents a novel approach to prepare composite catalytic filter for the simultaneous removal of NO and chlorobenzene at low temperatures.
基金Project supported by the Open Fund of Anhui Key Laboratory of Mine Intelligent Equipment and Technology (Grant No. ZKSYS202204)the Talent Introduction Fund of Anhui University of Science and Technology (Grant No. 2021yjrc34)the Scientific Research Fund of Anhui Provincial Education Department (Grant No. KJ2020A0301)。
文摘Implementing quantum wireless multi-hop network communication is essential to improve the global quantum network system. In this paper, we employ eight-level GHZ states as quantum channels to realize multi-hop quantum communication, and utilize the logical relationship between the measurements of each node to derive the unitary operation performed by the end node. The hierarchical simultaneous entanglement switching(HSES) method is adopted, resulting in a significant reduction in the consumption of classical information compared to multi-hop quantum teleportation(QT)based on general simultaneous entanglement switching(SES). In addition, the proposed protocol is simulated on the IBM Quantum Experiment platform(IBM QE). Then, the data obtained from the experiment are analyzed using quantum state tomography, which verifies the protocol's good fidelity and accuracy. Finally, by calculating fidelity, we analyze the impact of four different types of noise(phase-damping, amplitude-damping, phase-flip and bit-flip) in this protocol.
基金supported by the project“GEF9874:Strengthening Coordinated Approaches to Reduce Invasive Alien Species(lAS)Threats to Globally Significant Agrobiodiversity and Agroecosystems in China”funding from the Excellent Talent Training Funding Project in Dongcheng District,Beijing,with project number 2024-dchrcpyzz-9.
文摘Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental factors.These vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant challenge.To address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data registration.Specifically,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less efficient.Meanwhile,visual texture information complements LiDAR-Visual localization by providing additional contextual details.By incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of localization.This approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.
文摘The accuracy of thermal analysis measurements is critical to analyze material properties correctly,making the improvement of measurement precision and proper uncertainty analysis of test results absolutely essential.As a primary thermal analysis instrument,the simultaneous thermal analyzer(STA)has unique advantages,which combines the functionalities of thermogravimetric(TG)analyzersand differential scanning calorimeters(DSC).However,the absence of standard quality control procedures has resulted in poor measurement reproducibility,low accuracy,and inadequate traceability of analytical results.This study utilized a multi-point temperature calibration method based on national certified reference materials to reduce instrument temperature indication errors.On this basis,we innovatively established a comprehensive quality control system encompassing laboratory environmental control,standard method selection,instrument performance verification,reference material traceability,and uncertainty analysis,thereby achieving standardized operational procedures for thermal analysis measurement.Taking the"determination of initial melting temperature of unknown substances"as a representative case study,a component resolution model for thermal analysis test uncertainty was developed.Through systematic analysis of both the reference material-introduced component and measurement repeatability component,complete traceability of test results was achieved.This approach ensures data validity and enhances the accuracy of test results.This provides crucial technical support and practical reference for the standardization of thermal analysis measurement procedure and assessment of result reliability.
基金supported by National Natural Scienc Foundation of China(No.52400097)the Nanqiang Young Talents Supporting Program from Xiamen University.
文摘Fenton/Fenton-like reactions have gained popularity for their remarkable proficiency in decomposing organic pollutants,especially when enhanced by reductants addition for accel-erating the Fe2+regeneration.Nevertheless,these works predominantly centered on the formation and utilization of hydroxyl radicals(•OH)in the process,neglecting the evolution of oxidant and reductant due to the difficulty in the simultaneous determination of these two components.By employing the quenching-iodometric method,we could simultaneously determine the concentrations of HSO_(3)-and peroxydisulfate(PDS).This method first employed an excess of peroxymonosulfate(PMS)to effectively quench HSO_(3)-,and then used the iodometric spectrophotometry to simultaneously determine the concentrations of PMS and PDS in the reaction system.Finally,through precise stoichiometric relationships,we could accurately calculate the concentration of HSO_(3)-.Based on this method,we achieved concentration measurements that,upon linear fitting,yielded a correlation coefficient(R^(2))surpassing 0.99,unequivocally affirming the method’s accuracy and trustworthiness.In this work,an innovation approach for determining the concentrations of HSO_(3)-(reductant)and PDS(oxidant)was explored.Additionally,the resilience of the method was verified across different pH levels and in the presence of diverse impurity ions.The results ensured precise concentration measure-ments in the real wastewater.This method was characterized by its simplicity,rapid analysis,and environmental friendliness,offering a newanalytical strategy for the determination of PDS and HSO_(3)-in environmental samples.The method enables more meticulous monitoring of chemical usage in water treatment,facilitating optimized dosing strategies and assessments of reductant-enhanced Fenton or Fenton-like system in water purification.
基金supported by the National Natural Science Foundation of China(No.22278352)National Key Research and Development Program of China(No.2021YFC3001100)。
文摘Fibers with deformation-triggered responses are essential for smart textiles and wearable electronics.Here,smart core-shell elastomer fibers with a conductive core and a liquid crystal elastomer shell showing simultaneous resistance and color responses are designed and prepared.The conductive core is consisted of interconnected liquid metal nanodroplets dispersed in a polymer matrix and the elastomer shell is made of cholesteric liquid crystals.When stretched,the fiber resistance increases as the interconnected pathways of liquid metal nanodroplets along the fiber axis become narrower,and the selective reflection color from the fiber surface blueshifts since the cholesteric pitch decreases.The smart elastomer fibers could be woven into smart textiles and respond to various mechanical deformations,including stretching,bending,compression and twisting.The average resistance change is 51%under 100%strain and its variation is smaller than 4%over 500 cycles,showing remarkable fatigue resistance.The simultaneous resistance and color responses to mechanical deformations make the fibers attractive for broad applications,such as flexible electronics.
基金supported by the National Natural Science Foundation of China(NSFC)grants(Nos.41473122,41173113,52261145693 and 22106028)the Ministry of Science and Technology of the People’s Republic of China(MOST)+1 种基金the Fundamental Research Funds for the Central Universities(FRF-TP-19-020A1)the Hundred Talents Program of the Chinese Academy of Sciences,and China Postdoctoral Science Foundation(No.2023M730216).
文摘Arsenic and cadmium contamination frequently coexist in the real environment.However it remains a challenge for their simultaneous removal due to their distinct physicochemica properties at low cost.To this end,a cost-effective magnetic biochar adsorbent (ITBNa800was prepared using biomass waste and iron tailings slag.This composite adsorbent exhibits excellent performance in the simultaneous removal of aqueous As(Ⅴ) and Cd(Ⅱ) even at high concentrations with removal efficiencies of up to 99.98%and 96.04%,respectively.Electro static action,precipitation,and complexation were adsorption mechanisms.As(Ⅴ) and Cd(Ⅱ were synergistic and competitive adsorption.As(Ⅴ) removal was mainly due to physical and chemical adsorption,and 42.40%-58.59%of As(Ⅴ) had been converted to As(Ⅲ ).Cd(Ⅱ) re moval was mainly due to chemical adsorption.Iron oxide and aluminum oxide in ITBNa800were the keys to As(Ⅴ),As(Ⅲ ),and Cd(Ⅱ) adsorption.DFT calculations revealed iron oxide complex As(Ⅴ),As(Ⅲ ),and Cd(Ⅱ) molecular clusters through bidentate binuclear,bidentate binuclear,and monodentate binuclear pathways,respectively.Aluminum oxide complex Cd(Ⅱ) molecular cluster through a bidentate mononuclear pathway.We hope the ITBNa800adsorbent and its involved mechanism could offer inspiration in the simultaneous treat ment of As and Cd pollution.
基金supported by National Science and Technology Major Project(Grant No.2017ZX05018-001)。
文摘Deblending is a data processing procedure used to separate the source interferences of blended seismic data,which are obtained by simultaneous sources with random time delays to reduce the cost of seismic acquisition.There are three types of deblending algorithms,i.e.,filtering-type noise suppression algorithm,inversion-based algorithm and deep-learning based algorithm.We review the merits of these techniques,and propose to use a sparse inversion method for seismic data deblending.Filtering-based deblending approach is applicable to blended data with a low blending fold and simple geometry.Otherwise,it can suffer from signal distortion and noise leakage.At present,the deep learning based deblending methods are still under development and field data applications are limited due to the lack of high-quality training labels.In contrast,the inversion-based deblending approaches have gained industrial acceptance.Our used inversion approach transforms the pseudo-deblended data into the frequency-wavenumber-wavenumher(FKK)domain,and a sparse constraint is imposed for the coherent signal estimation.The estimated signal is used to predict the interference noise for subtraction from the original pseudo-deblended data.Via minimizing the data misfit,the signal can be iteratively updated with a shrinking threshold until the signal and interference are fully separated.The used FKK sparse inversion algorithm is very accurate and efficient compared with other sparse inversion methods,and it is widely applied in field cases.Synthetic example shows that the deblending error is less than 1%in average amplitudes and less than-40 dB in amplitude spectra.We present three field data examples of land,marine OBN(Ocean Bottom Nodes)and streamer acquisitions to demonstrate its successful applications in separating the source interferences efficiently and accurately.
基金supported by the National Key Research and Development Program of China(No.2021YFC3201505-02)Shenzhen Science and Technology Plan Collaborative Innovation Project-Undertake Major National Science and Technology Projects of China(No.CJGJZD2020061710260200).
文摘Heterotrophic denitrification based on polylactic acid(PLAHD)can remove nitrate effectively,but it is expensive and can't remove phosphate.Autotrophic denitrification based on iron sulfide(ISAD)can simultaneously remove nitrate and phosphate cost-effectively,but its nitrate rate is slow.So,iron sulfide mineral/polylactic acid mixotrophic biofilter(ISPLAB)was constructed to combine advantages of ISAD and PLAHD.ISPLAB achieved nitrogen and phosphorus removal rates of 98.04%and 94.12%,respectively,at a hydraulic retention time(HRT)of 24 h.The study also revealed that controlling molecular weight(MW)of PLA improved the release of soluble organic matter;adding iron sulfide enhanced the hydrolysis of PLA and precipitated PO_(4)^(3-) of Fe^(2+)/Fe^(3+),thereby facilitated simultaneous nitrogen and phosphorus removal.Microbial community analysis resulted that denitrifying bacterias(Phaeodactylibacter and Methylotenera),sulfur-reducing bacterias(Hyphomicrobium),sulfur-oxidizing bacteria(Denitratisoma),iron-reducing bacteria(Romboutsia)and hydrolyzed bacterias(norank_f_norank_o_1-20 and norank_f_Caldilineaceae)coexisted in the ISPLAB system.Organics and iron sulfide drived the denitrification process in ISPLAB.
文摘Correction to:Nuclear Science and Techniques(2024)36:8 https://doi.org/10.1007/s41365-024-01570-7 In this article the affiliation details for Author Jian Shan were incorrectly given as‘College of Physics and Electronic Engi-neering,Hengyang Normal University,Hengyang 421008,China’but should have been‘School of Nuclear Science and Technology,University of South China,Hengyang 421001,China’.The original article has been corrected.
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF),funded by the Ministry of Education(RS-202300243390 and 2020R1A5A1018052)supported by the Basic Science Research Program through the National Research Foundation of Korea,funded by the Ministry of Education(2022R1A3B1078163)supported by the Technology Innovation Program(Publicprivate joint investment semiconductor R&D program[K-CHIPS])to foster high-quality human resources(RS-2023-00235484)funded by the Ministry of Trade,Industry&Energy(MOTIE,Korea)(1415187770)。
文摘This study demonstrates the fabrication of mesoporous tungsten trioxide(WO_(3))-decorated flexible polyimide(PI)electrodes for the highly sensitive detection of catechol(CC)and hydroquinone(HQ),two environmental pollutants.Organic-inorganic composite dots are formed on flexible PI electrodes using evaporation-induced self-assembly(EISA)and electrospray methods.The EISA process is induced by a temperature gradient during electrospray,and the heated substrate partially decomposes the organic parts etched by O_(2) plasma,creating mesoporous structures.Differential pulse voltammetry and cyclic voltammetry demonstrate a linear correlation between analyte concentration and the electrochemical response.Computational studies support the spontaneous adsorption of CC and HQ molecules on model WO_(3) surfaces.The proposed sensor shows high sensitivity,a wide linear range,and a low detection limit for both individual and simultaneous determination of CC and HQ.Real sample analysis on river water confirms practical applicability.The WO_(3)-decorated PI electrode presents an efficient and reliable approach for detecting these pollutants,contributing to environmental safety measures.
基金Supported by the National Natural Science Foundation of China,No.82360111Xinjiang Science and Technology Department-Leading Talents in Technological Innovation-High-Level Leading Talents,No.2022TSYCLJ0034+1 种基金State Key Laboratory for The Cause and Control of High Incidence in Central Asia Jointly Constructed by The Ministry and The Province,No.SKL-HIDCA-2023-2 and No.SKLHIDCA-2024-22Xinjiang Uygur Autonomous Region Graduate Innovation Program,No.XJ2024G153.
文摘BACKGROUND Alveolar and cystic echinococcoses are lethal zoonotic diseases caused by Echinococcus multilocularis and Echinococcus granulosus infections,leading to alveolar echinococcosis(AE)or cystic echinococcosis(CE),respectively.No study has hitherto reported effective treatment approaches for AE or CE with concurrent hepatorenal involvement.AIM To investigate the feasibility and efficacy of simultaneous combined surgery(SCS)as a comprehensive treatment approach for patients with hepatorenal echinococcosis.METHODS Clinical datasets of hepatorenal AE(n=10)and CE(n=11)patients were retrospectively collected and systematically analyzed.The SCS approach was introduced,and surgical outcomes,complications,and prognoses were documented in detail.RESULTS The SCS approach incorporated hybridized techniques,including partial hepatectomy,partial or total nephrectomy,ex vivo liver resection and autotransplantation,and total or subtotal cystectomy with endocystectomy.Radical SCS was achieved in 100%of AE patients and 63.6%of CE patients.All surgeries were completed without intraoperative complications.The short-term complication rate was 28.6%(Clavien-Dindo classification:AE-1 IIIb,3 IIIa;CE-2 II),while the long-term complication rate was 4.8%(Clavien-Dindo classification:AE-1 IIIb).Patients were followed up for a median of 37 months(AE:6-81 months;CE:34-123 months),with no reported deaths or disease relapses.CONCLUSION CS appears to be a feasible and effective treatment method for patients with hepatorenal involvement of AE or CE.It fulfills the management criteria for advanced AE or CE cases,aiming to maximize patient benefits.
基金supported in part by the National Natural Science Foundation of China under Grant 62071094in part by the National Key Laboratory of Wireless Communications Foundation under Grant IFN202402in part by the Postdoctoral Fellowship Program(Grade C)of China Postdoctoral Science Foundation under Grant GZC20240217.
文摘To enable simultaneous transmit and receive(STAR)on the same frequency in a densely deployed space with multi-interference sources,this work proposes a digitally-assisted analog selfinterference cancellation method,which can acquire reference signals through flexible wired/wireless switching access.Based on this method,the Minimum Mean Square Error algorithm with known channel state information is derived in detail,determining the upper limit of the cancellation performance,and the Adaptive Dithered Linear Search algorithm for real-time engineering cancellation is given.The correctness of theoretical analysis is verified by the practical self-interference channel measured by a vector network analyzer.Furthermore,we have designed and implemented the corresponding multiinterference cancellation prototype with the digitallyassisted structure,capable of handling multiple interferences(up to three)and supporting a large receive bandwidth of 100 MHz as well as a wide frequency coverage from 30 MHz to 3000 MHz.Prototype test results demonstrate that in the presence of three interferences,when the single interference bandwidth is 0.2/2/20 MHz(corresponding to the receive bandwidth of 2/20/100 MHz),the cancellation performance can reach 46/32/22 dB or more.
文摘BACKGROUND Detailed data on the relation of post-operative complications with clinical outcomes after simultaneous pancreas-kidney(SPK)transplantation is lacking.AIM To compare Clavien-Dindo classification(CDC)and comprehensive complication index(CCI)in predicting outcomes after SPK.METHODS Data for patients undergoing SPK between 1999-2019 were analyzed.Information on recipients’baseline characteristics,peri-operative management and postoperative complications were collated.Length of hospital stay(LOS)was the primary study outcome,and the associations with CDC and CCI were evaluated using Spearman’s(ρ)correlation coefficients.RESULTS In the study period,data were available for 128 patients(female n=44,34.4%).Sixty-nine patients had at least one complication with the highest CDC grade of I,II,III,and IV in 8(6.3%),22(17.2%),32(25%),and 7(5.5%)patients,respectively. The mean LOS was 21.4 ± 17.7 days. Both classification systems were correlated with LOS, yet CCI was stronger(Spearman’s ρ: 0.694 vs 0.602, P < 0.001). Female patients (P = 0.019) and patients with pre-transplant cardiovascularevents (P = 0.02) had longer LOS. After adjusted multivariable analysis, the link between LOS and both theCDC and CCI remained relevant. CCI had a superior fit compared to CDC (r2 = 0.729 vs r2 = 0.481), with every 10CCI points being associated with a 5.27 day (P < 0.001) increased LOS.CONCLUSIONThis study showed that the CCI was better linked with LOS compared to CDC and might represent a useful scoreto evaluate the overall burden of postoperative complications in patients undergoing SPK.
文摘This paper addresses the Multi-Vehicle Routing Problem with Time Windows and Simultaneous Pickup and Delivery(MVRPTWSPD),aiming to optimize logistics distribution routes and minimize total costs.A vehicle routing optimization model is developed based on the operational requirements of the KS Logistics Center,focusing on minimizing vehicle dispatch,loading and unloading,operating,and time window penalty costs.The model incorporates constraints such as vehicle capacity,time windows,and travel distance,and is solved using a genetic algorithm to ensure optimal route planning.Through MATLAB simulations,34 customer points are analyzed,demonstrating that the simultaneous pickup and delivery model reduces total costs by 30.13%,increases vehicle loading rates by 20.04%,and decreases travel distance compared to delivery-only or pickup-only models.The results demonstrate the significant advantages of the simultaneous pickup and delivery mode in reducing logistics costs and improving vehicle utilization,offering valuable insights for enhancing the operational efficiency of the KS Logistics Center.
基金supported by the National Natural Science Foundation of China(Nos.21874060 and 22174058,U21A20282)the Science and Technology program of Gansu Province(No.22JR5RA476)。
文摘DNA repair enzymes are important in the repair of DNA lesions for maintaining the genome stability,and their abnormal expression induced various human cancers.Simultaneous detection of these DNA enzymes could provide convincing evidence based on the comparison of the activity of multiple enzymes than on that of single enzyme.Although fluorescence approach has been applied for the simultaneous detection both of DNA repair enzymes,the spectral overlap and multiwavelength excitation severely restrict the number of available fluorophores.Thus,it is difficult to simultaneously detect three enzymes in a single analysis by fluorescence detection.Herein,we developed a method for the simultaneous determination of three DNA repair enzymes including human flap DNA endonuclease 1(FEN1),human alkyladenine DNA glycosylase(hAAG)and uracil DNA glycosylase(UDG)based on the combination of template-free amplification system with capillary electrophoresis-laser induced fluorescence(CE-LIF)detection.The amplification system was adopted to transfer and amplify the enzymatic products into different length DNA fragments which could be separated effectively by CE-LIF without the complicated modification of the capillary inner wall or labeling different tails on signal probes for separation.The method demonstrated a detection limit of 0.07 U/mL(0.08-160 U/mL)for FEN1,2.40 U/mL(2.5-250U/mL)for hAAG and 2.1×10^(-4)U/mL(0.0004-2.5 U/mL)for UDG,the relative standard deviations(RSDs)of peak time and peak area for different analytes were as follows:2.50%-4,37%and 3.24%-7.18%(inter-day);1.37%-2.71%and 1.43%-3.02%(intra-day),4.28%-6.08%and 4.16%-7.57%(column to column),respectively.And it can identify the inhibitor-like drugs,evaluate enzymatic kinetics and achieve the detection of three enzymes in cell extracts,providing a simple and powerful platform for simultaneous detection of more DNA repair enzymes.
文摘The“First Multidisciplinary Forum on COVID-19,”as one of the pivotal medical forums organized by China during the initial outbreak of the pandemic,garnered significant attention from numerous countries worldwide.Ensuring the seamless execution of the forum’s translation necessitated exceptionally high standards for simultaneous interpreters.This paper,through the lens of the Translation as Adaptation and Selection theory within Eco-Translatology,conducts an analytical study of the live simultaneous interpretation at the First Multidisciplinary Forum on COVID-19.It examines the interpreters’adaptations and selections across multiple dimensions-namely,linguistic,cultural,and communicative-with the aim of elucidating the guiding role and recommendations that Eco-Translatology can offer to simultaneous interpretation.Furthermore,it seeks to provide insights that may enhance the quality of interpreters’oral translations.
