Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s disease.However,the molecular mechanisms underlying this association are not complet...Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s disease.However,the molecular mechanisms underlying this association are not completely understood.Among the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central role.Here,we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain,highlighting the role of interleukins and,in particular,interleukin 1βas a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions.展开更多
BACKGROUND Aseptic meningitis is defined as meningeal inflammation caused by various etio-logies with negative cerebrospinal fluid(CSF)bacterial culture.The most common etiologies are viruses[enteroviruses,arboviruses...BACKGROUND Aseptic meningitis is defined as meningeal inflammation caused by various etio-logies with negative cerebrospinal fluid(CSF)bacterial culture.The most common etiologies are viruses[enteroviruses,arboviruses,and herpes simplex virus type 2(HSV-2)].Aseptic meningitis can have various presentations,including sensori-neural deafness.While sensorineural deafness from mumps meningoencephalitis has been reported,cases of HSV-2-induced hearing loss are rare.Herein,we re-port a case of HSV-2-induced meningitis that presented with sudden deafness.CASE SUMMARY A 68-year-old man experienced a profound sudden onset of left-sided hearing loss for one day.Pure-tone audiograms demonstrated sudden left-sided sensorineural hearing loss(thresholds 80-90 dB).After treatment with high-dose steroids for 1 week,he experienced an acute consciousness change with left hemiparesis.The laboratory data showed no significant abnormalities.Brain computed tomography without contrast and magnetic resonance imaging revealed no intracranial hemo-rrhage or obvious brain lesion.The CSF analysis and the Multiplex PCR panels showed HSV-2 positivity.Hence,under the diagnosis of herpes meningoenceph-alitis,acyclovir was prescribed and his symptoms gradually resolved.CONCLUSION This case report further demonstrates that a viral infection could be a cause of sudden sensorineural hearing loss.展开更多
Quercetin is a natural compound with potent antiviral effects;however,its role in the treatment of herpes simplex keratitis(HSK)remains underexplored.Here,we investigated the antiviral effects of quercetin against her...Quercetin is a natural compound with potent antiviral effects;however,its role in the treatment of herpes simplex keratitis(HSK)remains underexplored.Here,we investigated the antiviral effects of quercetin against herpes simplex virus 1(HSV-1).By examining different phases of viral infection in human corneal epithelial cells(HCECs),we found that 30μmol/L quercetin inhibits HSV-1 replication primarily by disrupting viral attachment.RNA-sequencing and subsequent analyses revealed that the nuclear factor E2-related factor 2(Nrf2)was upregulated by quercetin in a dose-dependent manner.Knocking down Nrf2 partially compromised quercetin's antiviral effect.Importantly,topical application of 100μmol/L quercetin alleviated HSK severity in mice,reduced viral titers in tears,and inhibited VP16 expression in the cornea and trigeminal ganglia.These findings demonstrate the antiviral effect of quercetin against HSV-1 and provide a foundation for mechanistic studies to elucidate its therapeutic potential in HSK.展开更多
为了改善高压直流系统的故障后的恢复性能,在研究低压限流单元(voltage dependent current order limiter,VDCOL)对直流系统无功功率消耗和电压稳定性影响的基础上,提出了一种分段变速率低压限流单元(piecewise-variable-rate VDCOL,PVR...为了改善高压直流系统的故障后的恢复性能,在研究低压限流单元(voltage dependent current order limiter,VDCOL)对直流系统无功功率消耗和电压稳定性影响的基础上,提出了一种分段变速率低压限流单元(piecewise-variable-rate VDCOL,PVR-VDCOL)的控制方法,该方法通过将电压下降或恢复过程划分为几个不同的阶段,并在每个阶段根据电压水平的不同而设置不同的功率恢复速率。推导了控制器初值的计算公式,制定了利用Simplex算法优化控制器参数的流程,并重点分析了分段数目对控制器性能的影响及其确定方法。在PSCAD/EMTDC中对提出的PVR-VDCOL和传统线性VDCOL的控制效果进行了对比仿真,并对不同分段数目下的仿真结果进行了对比分析,仿真结果表明提出的PVR-VDCOL能够有效改善直流系统的恢复性能。展开更多
The mid-facet of a simplex in n-dimensional Euclidean space which was introduced quite recently is an important geometric element. An analytic expression for the mid-facet area of a simplex is firstly given. In order ...The mid-facet of a simplex in n-dimensional Euclidean space which was introduced quite recently is an important geometric element. An analytic expression for the mid-facet area of a simplex is firstly given. In order to obtain the expression,the exterior differential method was presented. Furthermore, the properties of the mid-facets of a simplex analogous to median lines of a triangle (such as for all mid-facets of a simplex,there exists another simplex such that its edge-lengths equal to these mid-facets area respectively, and all of the mid-facets of a simplex have a common point) were proved. Finally, by applying the analytic expression, a number of inequalities which combine edge-lengths, circumradius, median line, bisection area and facet area with the mid-facet area for a simplex were established.展开更多
Let A={A_1, A_2,…, A_(n+1)} be a simplex in E^n which its center O of circumscribed sphere is in inside of A. If R and R_i are radiuses of A_i respectively (A_i={A_1, A_2,…, A_(i-1), O, A_(i+1),…,A_(n+1)} ,i=1,2,…...Let A={A_1, A_2,…, A_(n+1)} be a simplex in E^n which its center O of circumscribed sphere is in inside of A. If R and R_i are radiuses of A_i respectively (A_i={A_1, A_2,…, A_(i-1), O, A_(i+1),…,A_(n+1)} ,i=1,2,…,n+1),then we have The equality holds if and only if A is a regular simplex.展开更多
With Firmiana simplex （L.） W. F. Wight as an experiment material, the effects of different concentrations of GA3 （Gibberellin A3）, SA （Salicylic acid） and NAA （1-Naphthalene acetic acid） and stratification on ...With Firmiana simplex （L.） W. F. Wight as an experiment material, the effects of different concentrations of GA3 （Gibberellin A3）, SA （Salicylic acid） and NAA （1-Naphthalene acetic acid） and stratification on the germination rate of seeds were studied firstly, and then the effects of GA3 and NAA on seedling growth were analyzed. The results showed that the germination rate could be improved by 0.075 g/L SA and stratification markedly. It was indicated by the experiment that the growth of the main root and main stem could be promoted by 0.050 g/L and 0.077 g/L NAA, respectively. However, the leaf length and leaf width decreased significantly in the GA3 and NAA treatments.展开更多
基金supported by UniversitàCattolica(D1 intramural funds to RP)Italian Ministry of University and Research(PRIN 2022ZYLB7B,P2022YW7BP funds to CG).
文摘Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s disease.However,the molecular mechanisms underlying this association are not completely understood.Among the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central role.Here,we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain,highlighting the role of interleukins and,in particular,interleukin 1βas a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions.
文摘BACKGROUND Aseptic meningitis is defined as meningeal inflammation caused by various etio-logies with negative cerebrospinal fluid(CSF)bacterial culture.The most common etiologies are viruses[enteroviruses,arboviruses,and herpes simplex virus type 2(HSV-2)].Aseptic meningitis can have various presentations,including sensori-neural deafness.While sensorineural deafness from mumps meningoencephalitis has been reported,cases of HSV-2-induced hearing loss are rare.Herein,we re-port a case of HSV-2-induced meningitis that presented with sudden deafness.CASE SUMMARY A 68-year-old man experienced a profound sudden onset of left-sided hearing loss for one day.Pure-tone audiograms demonstrated sudden left-sided sensorineural hearing loss(thresholds 80-90 dB).After treatment with high-dose steroids for 1 week,he experienced an acute consciousness change with left hemiparesis.The laboratory data showed no significant abnormalities.Brain computed tomography without contrast and magnetic resonance imaging revealed no intracranial hemo-rrhage or obvious brain lesion.The CSF analysis and the Multiplex PCR panels showed HSV-2 positivity.Hence,under the diagnosis of herpes meningoenceph-alitis,acyclovir was prescribed and his symptoms gradually resolved.CONCLUSION This case report further demonstrates that a viral infection could be a cause of sudden sensorineural hearing loss.
基金supported by the National Natural Science Foundation of China(No.81970848).
文摘Quercetin is a natural compound with potent antiviral effects;however,its role in the treatment of herpes simplex keratitis(HSK)remains underexplored.Here,we investigated the antiviral effects of quercetin against herpes simplex virus 1(HSV-1).By examining different phases of viral infection in human corneal epithelial cells(HCECs),we found that 30μmol/L quercetin inhibits HSV-1 replication primarily by disrupting viral attachment.RNA-sequencing and subsequent analyses revealed that the nuclear factor E2-related factor 2(Nrf2)was upregulated by quercetin in a dose-dependent manner.Knocking down Nrf2 partially compromised quercetin's antiviral effect.Importantly,topical application of 100μmol/L quercetin alleviated HSK severity in mice,reduced viral titers in tears,and inhibited VP16 expression in the cornea and trigeminal ganglia.These findings demonstrate the antiviral effect of quercetin against HSV-1 and provide a foundation for mechanistic studies to elucidate its therapeutic potential in HSK.
文摘为了改善高压直流系统的故障后的恢复性能,在研究低压限流单元(voltage dependent current order limiter,VDCOL)对直流系统无功功率消耗和电压稳定性影响的基础上,提出了一种分段变速率低压限流单元(piecewise-variable-rate VDCOL,PVR-VDCOL)的控制方法,该方法通过将电压下降或恢复过程划分为几个不同的阶段,并在每个阶段根据电压水平的不同而设置不同的功率恢复速率。推导了控制器初值的计算公式,制定了利用Simplex算法优化控制器参数的流程,并重点分析了分段数目对控制器性能的影响及其确定方法。在PSCAD/EMTDC中对提出的PVR-VDCOL和传统线性VDCOL的控制效果进行了对比仿真,并对不同分段数目下的仿真结果进行了对比分析,仿真结果表明提出的PVR-VDCOL能够有效改善直流系统的恢复性能。
文摘The mid-facet of a simplex in n-dimensional Euclidean space which was introduced quite recently is an important geometric element. An analytic expression for the mid-facet area of a simplex is firstly given. In order to obtain the expression,the exterior differential method was presented. Furthermore, the properties of the mid-facets of a simplex analogous to median lines of a triangle (such as for all mid-facets of a simplex,there exists another simplex such that its edge-lengths equal to these mid-facets area respectively, and all of the mid-facets of a simplex have a common point) were proved. Finally, by applying the analytic expression, a number of inequalities which combine edge-lengths, circumradius, median line, bisection area and facet area with the mid-facet area for a simplex were established.
文摘Let A={A_1, A_2,…, A_(n+1)} be a simplex in E^n which its center O of circumscribed sphere is in inside of A. If R and R_i are radiuses of A_i respectively (A_i={A_1, A_2,…, A_(i-1), O, A_(i+1),…,A_(n+1)} ,i=1,2,…,n+1),then we have The equality holds if and only if A is a regular simplex.
基金Supported by the Regional Fund of Natural Science Foundation of China(31360065)Fund for the Construction of Provincial Superiority Characteristic Key Discipline Ecology~~
文摘With Firmiana simplex （L.） W. F. Wight as an experiment material, the effects of different concentrations of GA3 （Gibberellin A3）, SA （Salicylic acid） and NAA （1-Naphthalene acetic acid） and stratification on the germination rate of seeds were studied firstly, and then the effects of GA3 and NAA on seedling growth were analyzed. The results showed that the germination rate could be improved by 0.075 g/L SA and stratification markedly. It was indicated by the experiment that the growth of the main root and main stem could be promoted by 0.050 g/L and 0.077 g/L NAA, respectively. However, the leaf length and leaf width decreased significantly in the GA3 and NAA treatments.
