In this paper,the influence of the El NioSouthern Oscillation (ENSO) cycle on the sensitivity of nonlinear factors in the numerical simulation is investigated by conducting numerical experiments in a simple air-sea co...In this paper,the influence of the El NioSouthern Oscillation (ENSO) cycle on the sensitivity of nonlinear factors in the numerical simulation is investigated by conducting numerical experiments in a simple air-sea coupled model for ENSO prediction.Two sets of experiments are conducted in which zonal nonlinear factors,meridional nonlinear factors,or both are incorporated into the governing equations for the atmosphere or ocean.The results suggest that the ENSO cycle is very sensitive to the nonlinear factor of the governing equation for the atmosphere or ocean.Thus,incorporating nonlinearity into air-sea coupled models is of exclusive importance for improving ENSO simulation.展开更多
Let γ＊（D） denote the twin domination number of digraph D and let Cm Cn denote the Cartesian product of C_m and C_n, the directed cycles of length m, n ≥ 2. In this paper, we determine the exact values： γ＊（C_2...Let γ＊（D） denote the twin domination number of digraph D and let Cm Cn denote the Cartesian product of C_m and C_n, the directed cycles of length m, n ≥ 2. In this paper, we determine the exact values： γ＊（C_2□C_n） = n; γ＊（C_3 □C_n） = n if n ≡ 0（mod 3）,otherwise, γ＊（C_3□C_n） = n ＋ 1; γ＊（C_4□C_n） = n ＋ n/2 if n ≡ 0, 3, 5（mod 8）, otherwise,γ＊（C_4□C_n） = n ＋ n/2 ＋ 1; γ＊（C_5□C_n） = 2n; γ＊（C_6□C_n） = 2n if n ≡ 0（mod 3）, otherwise,γ＊（C_6□C_n） = 2n ＋ 2.展开更多
In this note, it is proved that if α≥0.24817, then any digraph on n vertices with minimum outdegree at least αn contains a directed cycle of length at most 5.
A proper edge t-coloring of a graph G is a coloring of its edges with colors 1,2,???,t such that all colors are used, and no two adjacent edges receive the same color. A cyclically interval t-coloring of a graph G is ...A proper edge t-coloring of a graph G is a coloring of its edges with colors 1,2,???,t such that all colors are used, and no two adjacent edges receive the same color. A cyclically interval t-coloring of a graph G is a proper edge t-coloring of G such that for each its vertex x, either the set of colors used on edges incident to x or the set of colors not used on edges incident to x forms an interval of integers. For an arbitrary simple cycle, all possible values of t are found, for which the graph has a cyclically interval t-coloring.展开更多
Let D be a finite simple directed graph with vertex set V(D) and arc set A(D). A function ?is called a signed dominating function (SDF) if ?for each vertex . The weight ?of f is defined by . The signed domination numb...Let D be a finite simple directed graph with vertex set V(D) and arc set A(D). A function ?is called a signed dominating function (SDF) if ?for each vertex . The weight ?of f is defined by . The signed domination number of a digraph D is . Let Cm × Cn denotes the cartesian product of directed cycles of length m and n. In this paper, we determine the exact values of gs(Cm × Cn) for m = 8, 9, 10 and arbitrary n. Also, we give the exact value of gs(Cm × Cn) when m, ?(mod 3) and bounds for otherwise.展开更多
We generalize Biggs Theorem to the case of directed cycles of multi-digraphs allowing to compute the dimension of the directed cycle space independently of the graph representation with linear runtime complexity. By c...We generalize Biggs Theorem to the case of directed cycles of multi-digraphs allowing to compute the dimension of the directed cycle space independently of the graph representation with linear runtime complexity. By considering two-dimensional CW complex of elementary cycles and deriving formulas for the Betti numbers of the associated cellular homology groups, we extend the list of representation independent topological inavariants measuring the graph structure. We prove the computation of the 2nd Betti number to be sharp #P hard in general and present specific representation invariant sub-fillings yielding efficiently computable homology groups. Finally, we suggest how to use the provided structural measures to shed new light on graph theoretical problems as graph embeddings, discrete Morse theory and graph clustering.展开更多
This study investigated the effect of thermal cycles on Cu-modified Ti64 thin-walled components deposited using the wire-arc directed energy deposition(wire-arc DED)process.For the samples before and after experiencin...This study investigated the effect of thermal cycles on Cu-modified Ti64 thin-walled components deposited using the wire-arc directed energy deposition(wire-arc DED)process.For the samples before and after experiencing thermal cycles,it was found that both microstructures consisted of priorβ,grain boundaryα(GBα),and basketweave structures containingα+βlamellae.Thermal cycles realized the refinement ofαlaths,the coarsening of priorβgrains andβlaths,while the size and morphology of continuously distributed GBαremained unchanged.The residualβcontent was increased after thermal cycles.Compared with the heat-treated sample with nanoscale Ti2Cu formed,short residence time in high temperature caused by the rapid cooling rate of thermal cycles restricted Ti2Cu formation.No formation of brittle Ti2Cu means that only grain refinement strengthening and solid-solution strengthening matter.The yield strength increased from 809.9 to 910.85 MPa(12.46%increase).Among them,the main contribution from solid solution strengthening(~51 MPa)was due to the elemental redistribution effect betweenαandβphases caused by thermal cycles through quantitative analysis.The ultimate tensile strength increased from 918.5 to 974.22 MPa(6.1%increase),while fracture elongation increased from 6.78 to 10.66%(57.23%increase).Grain refinement ofαlaths,the promotedα′martensite decomposition,decreased aspect ratio,decreased Schmid factor,and local misorientation change ofαlaths are the main factors in improved ductility.Additionally,although the fracture modes of the samples in the top and middle regions are both brittle-ductile mixed fracture mode,the thermal cycles still contributed to an improvement in tensile ductility.展开更多
Plant roots are widely known to provide mechanical reinforcement to soils against shearing and further increase slope stability.However,whether roots provide reinforcement to loess cyclic re-sistance and how various f...Plant roots are widely known to provide mechanical reinforcement to soils against shearing and further increase slope stability.However,whether roots provide reinforcement to loess cyclic re-sistance and how various factors affect roots reinforcement during seismic loading have rarely been studied.The objective is to conduct a series of cyclic direct simple shear tests and DEM numerical simulation to investigate the cyclic behaviour of rooted loess.The effects of initial static shear stress and loading frequency on the cyclic resistance of root-soil composites were first investigated.After that,cyclic direct simple shear simulations at constant volume were carried out based on the discrete element method(PFC^(3D))to investigate the effects of root geome-try,mechanical traits and root-soil bond strength on the cyclic strength of rooted loess.It was discovered that the roots could effectively improve the cyclic resistance of loess.The cyclic resistance of the root-soil composite decreases with the increase of the initial shear stress,then increases,and improves with the increase of the frequency.The simulation result show that increases in root elastic modulus and root-soil interfacial bond strength can all enhance the cyclic resistance of root-soil composites,and the maximum cyclic resistance of the root-soil composite was obtained when the initial inclination angle of the root system was 90°.展开更多
A simple graph G on n vettices is said to be a simple MCD-graph if G has no two cyties having the same length and has the maximum possible number of edges.Two results of the number of cy cles in G are given by introdu...A simple graph G on n vettices is said to be a simple MCD-graph if G has no two cyties having the same length and has the maximum possible number of edges.Two results of the number of cy cles in G are given by introdueing the Concept of a path decomposition and by them,the following theorem is proved:If G is a simple MCD-graph,then G is not a 2-connected planar graph and for all n except seven integer,G is not a 2-connected graph on n vertices containing a subgraph homeomor phic to K_4.展开更多
Thin-wall structures of Ti-6A1-4V were fabricated by low-power pulsed laser directed energy deposition. During deposition, consistent with prior reports, columnar grains were observed which grew from the bottom toward...Thin-wall structures of Ti-6A1-4V were fabricated by low-power pulsed laser directed energy deposition. During deposition, consistent with prior reports, columnar grains were observed which grew from the bottom toward the top of melt pool tail. This resulted in a microstructure mainly composed of long and thin prior epitaxial β columnar grains (average width ^200μm). A periodic pattern in epitaxial growth of grains was observed, which was shown to depend upon laser traverse direction. Utilizing this, a novel means was proposed to determine accurately the fusion boundary of each deposited layer by inspection of the periodic wave patterns. As a result it was applied to investigate the influence of thermal cycling on microstructure evolution. Results showed that acicular martensite,α' phase, and a small amount of Widmanstatten, a laths, gradually converted to elongated acicular a and a large fraction of Widmanstatten a laths under layer-wise thermal cycling. Tensile tests showed that the yield strength, ultimate tensile strength and elongation of Ti-6Al-4V thin wall in the build direction were 9.1 %, 17.3% and 42% higher respectively than those typically observed in forged solids of the same alloy. It also showed the yield strength and ultimate tensile strength of the transverse tensile samples both were 13.3% higher than those from the build direction due to the strengthening effect of a large number of vertical β grain boundaries, but the elongation was 69.7% lower than that of the build direction due to the uneven grain deformation of β grains.展开更多
Cell cycle regulation and brain injury:Traumatic brain injury(TBI)is one of the primary causes of morbidity and mortality in patients,and it affects more than 1.7 million Americans each year.Other than direct damage r...Cell cycle regulation and brain injury:Traumatic brain injury(TBI)is one of the primary causes of morbidity and mortality in patients,and it affects more than 1.7 million Americans each year.Other than direct damage resulting from TBI,the brain injury triggers several secondary mechanisms which either individually or in combination contribute to the neurological deficits after TBI(Gupta and Sen,2016).These secondary mechanisms include neuronal death and stimulate proliferation of astrocytes and microglial cells,which in turn triggers neuro-inflammation(Simon et al.,2017).展开更多
Carbamoyl phosphate synthetase i （CPS1） deficiency （CPS1D） is an inborn error of the urea cycle having autosomal （2q34） recessive inheritance that can cause hyperammonemia and neonatal death or mental retardatio...Carbamoyl phosphate synthetase i （CPS1） deficiency （CPS1D） is an inborn error of the urea cycle having autosomal （2q34） recessive inheritance that can cause hyperammonemia and neonatal death or mental retardation. We analyzed the effects on CPS1 activity, kinetic parameters and enzyme stability of missense mutations reported in patients with CPS1 deficiency that map in the 20-kDa C-terminal domain of the enzyme. This domain turns on or off the enzyme depending on whether the essential allosteric activator of CPS 1, N-acetyl- L-glutamate （NAG）, is bound or is not bound to it. To carry out the present studies, we exploited a novel system that allows the expression in vitro and the purification of human CPS1, thus permitting site-directed mutagenesis. These studies have clarified disease causation by individual mutations, identifying functionally important residues, and revealing that a number of mutations decrease the affinity of the enzyme for NAG. Patients with NAG affinity-decreasing mutations might benefit from NAG site saturation therapy with N-carbamyl-L- glutamate （a registered drug, the analog of NAG）. Our results, together with additional present and prior site-directed mutagenesis data for other residues mapping in this domain, suggest an NAG-triggered conformational change in the 134-~4 loop of the C-terminal domain of this enzyme. This change might be an early event in the NAG activation process. Molecular dynamics simulations that were restrained according to the observed effects of the mutations are consistent with this hypothesis, providing further backing for this structurally plausible signaling mechanism by which NAG could trigger urea cycle activation via CPS1.展开更多
Direct laser deposition(DLD),as a popular metal additive manufacturing process,shows advantages of technical flexibility and high efficiency to gain a high-performance alloy steel component.However,during the processi...Direct laser deposition(DLD),as a popular metal additive manufacturing process,shows advantages of technical flexibility and high efficiency to gain a high-performance alloy steel component.However,during the processing of DLD,the deposited steel layer is affected by the subsequent layer depositing.The DLD block shows different microstructure and mechanical properties at the bottom,middle and top of the deposited parts.To date,there are few research works about the effects of inter-layer interval time and laser power on the microstructure evolution and mechanical properties of the deposited layers.In this study,the idle time and laser power layer by layer during DLD of 12CrNi2 steel were controlled to cause the deposited layers to maintain a high cooling rate,while the bottom deposited layer was subjected to a weak tempering effect.Results show that a high proportion of martensite is produced,which improves the strength of the deposited layer.Under the laser scanning strategy of laser power 2,500 W,scanning velocity 5 mm·s^(-1),powder feeding rate 11 g·min^(-1),overlap rate 50%,and a laser power difference of 50 W and a 2 min interval,the tensile strength of the deposited layer of 12CrNi2 steel is in the range of 873-1,022 MPa,and the elongation is in the range of 16.2%-18.9%.This study provides a method to reduce the tempering effect of the subsequent deposition layers on the bottom layers,which can increase the proportion of martensite in the low-alloy high-strength steel,so as to improve the yield strength of the alloy steel.展开更多
To design the optimum acceleration control schedule for the Adaptive Cycle Engine(ACE)in the full flight envelope,this paper establishes a direct simulation model of the ACE transient state.In this model,geometric par...To design the optimum acceleration control schedule for the Adaptive Cycle Engine(ACE)in the full flight envelope,this paper establishes a direct simulation model of the ACE transient state.In this model,geometric parameters are used to replace the component state parameters.The corresponding relationship between geometric parameters and component state parameters is determined by sensitivity analysis.The geometric variables are controlled when the geometric adjustment speed exceeds the limit,and at the same time the corresponding component state parameters are iterated.The gradient optimization algorism is used to optimize the ground acceleration process of ACE,and the control schedule in terms of operating point of compression components and corrected acceleration rate is used as the full-envelope acceleration control schedule based on the similarity principle.The acceleration control schedules of the triple-bypass mode and the double-bypass mode are designed in this paper.The acceleration processes under various flight conditions are simulated using the acceleration control schedules.Compared with the acceleration process with the linear geometric adjustment schedule,the acceleration performance of ACE is improved by the acceleration control schedule,with the impulse of the acceleration process of the triple-bypass mode being increased by 8.7%-12.3% and the impulse of the double-bypass mode acceleration process being increased by 11.8%-14.1%.展开更多
Within the framework of plane-wave angular spectrum analysis of the electromagnetic field structure, a solution valid for tightly focused radially polarized few-cycle laser pulses propagating in vacuum is presented. T...Within the framework of plane-wave angular spectrum analysis of the electromagnetic field structure, a solution valid for tightly focused radially polarized few-cycle laser pulses propagating in vacuum is presented. The resulting field distribution is significantly different from that based on the paraxial approximation for pulses with either small or large beam diameters. We compare the electron accelerations obtained with the two solutions and find that the energy gain obtained with our new solution is usually much larger than that with the paraxial approximation solution.展开更多
Complement is a typical feature of Chinese grammar, and it seldom appears in other languages. Because of its complexity, it is very difficult for Chinese learners all over the world. The paper takes seven groups of si...Complement is a typical feature of Chinese grammar, and it seldom appears in other languages. Because of its complexity, it is very difficult for Chinese learners all over the world. The paper takes seven groups of simple directional complement （SDC）, ＂V-Shang＂, ＂V-Xia＂, ＂V-Jin＂, ＂V-Chu＂, ＂V-Kai＂, ＂V-Qi＂, and ＂V-Hui＂, as research goals. The investigation on second language acquisition （SLA） is carried out in terms of different native languages. The conclusion can be drawn that native language has a close relationship with SLA, because of their difference in Semantic Incorporation. In addition, the category of SDC is also an important factor influencing SLA.展开更多
基金supported by the National Natural Science Foundation of China (Grant No.40676016)
文摘In this paper,the influence of the El NioSouthern Oscillation (ENSO) cycle on the sensitivity of nonlinear factors in the numerical simulation is investigated by conducting numerical experiments in a simple air-sea coupled model for ENSO prediction.Two sets of experiments are conducted in which zonal nonlinear factors,meridional nonlinear factors,or both are incorporated into the governing equations for the atmosphere or ocean.The results suggest that the ENSO cycle is very sensitive to the nonlinear factor of the governing equation for the atmosphere or ocean.Thus,incorporating nonlinearity into air-sea coupled models is of exclusive importance for improving ENSO simulation.
基金Supported by the National Natural Science Foundation of China(Grant Nos.6136302011301450+2 种基金11226294)the Youth Science and Technology Education Project of Xinjiang(Grant No.2013731011)China Scholarship Council
文摘Let γ＊（D） denote the twin domination number of digraph D and let Cm Cn denote the Cartesian product of C_m and C_n, the directed cycles of length m, n ≥ 2. In this paper, we determine the exact values： γ＊（C_2□C_n） = n; γ＊（C_3 □C_n） = n if n ≡ 0（mod 3）,otherwise, γ＊（C_3□C_n） = n ＋ 1; γ＊（C_4□C_n） = n ＋ n/2 if n ≡ 0, 3, 5（mod 8）, otherwise,γ＊（C_4□C_n） = n ＋ n/2 ＋ 1; γ＊（C_5□C_n） = 2n; γ＊（C_6□C_n） = 2n if n ≡ 0（mod 3）, otherwise,γ＊（C_6□C_n） = 2n ＋ 2.
文摘In this note, it is proved that if α≥0.24817, then any digraph on n vertices with minimum outdegree at least αn contains a directed cycle of length at most 5.
文摘A proper edge t-coloring of a graph G is a coloring of its edges with colors 1,2,???,t such that all colors are used, and no two adjacent edges receive the same color. A cyclically interval t-coloring of a graph G is a proper edge t-coloring of G such that for each its vertex x, either the set of colors used on edges incident to x or the set of colors not used on edges incident to x forms an interval of integers. For an arbitrary simple cycle, all possible values of t are found, for which the graph has a cyclically interval t-coloring.
文摘Let D be a finite simple directed graph with vertex set V(D) and arc set A(D). A function ?is called a signed dominating function (SDF) if ?for each vertex . The weight ?of f is defined by . The signed domination number of a digraph D is . Let Cm × Cn denotes the cartesian product of directed cycles of length m and n. In this paper, we determine the exact values of gs(Cm × Cn) for m = 8, 9, 10 and arbitrary n. Also, we give the exact value of gs(Cm × Cn) when m, ?(mod 3) and bounds for otherwise.
文摘We generalize Biggs Theorem to the case of directed cycles of multi-digraphs allowing to compute the dimension of the directed cycle space independently of the graph representation with linear runtime complexity. By considering two-dimensional CW complex of elementary cycles and deriving formulas for the Betti numbers of the associated cellular homology groups, we extend the list of representation independent topological inavariants measuring the graph structure. We prove the computation of the 2nd Betti number to be sharp #P hard in general and present specific representation invariant sub-fillings yielding efficiently computable homology groups. Finally, we suggest how to use the provided structural measures to shed new light on graph theoretical problems as graph embeddings, discrete Morse theory and graph clustering.
基金sponsored by the National Key Laboratory Foundation of Science and Technology on Materials under Shock and Impact 2021ZX52002222019the Natural Science Foundation of China(NSFC No.U2141216)the Chongqing Technology Innovation and Application Special Program.
文摘This study investigated the effect of thermal cycles on Cu-modified Ti64 thin-walled components deposited using the wire-arc directed energy deposition(wire-arc DED)process.For the samples before and after experiencing thermal cycles,it was found that both microstructures consisted of priorβ,grain boundaryα(GBα),and basketweave structures containingα+βlamellae.Thermal cycles realized the refinement ofαlaths,the coarsening of priorβgrains andβlaths,while the size and morphology of continuously distributed GBαremained unchanged.The residualβcontent was increased after thermal cycles.Compared with the heat-treated sample with nanoscale Ti2Cu formed,short residence time in high temperature caused by the rapid cooling rate of thermal cycles restricted Ti2Cu formation.No formation of brittle Ti2Cu means that only grain refinement strengthening and solid-solution strengthening matter.The yield strength increased from 809.9 to 910.85 MPa(12.46%increase).Among them,the main contribution from solid solution strengthening(~51 MPa)was due to the elemental redistribution effect betweenαandβphases caused by thermal cycles through quantitative analysis.The ultimate tensile strength increased from 918.5 to 974.22 MPa(6.1%increase),while fracture elongation increased from 6.78 to 10.66%(57.23%increase).Grain refinement ofαlaths,the promotedα′martensite decomposition,decreased aspect ratio,decreased Schmid factor,and local misorientation change ofαlaths are the main factors in improved ductility.Additionally,although the fracture modes of the samples in the top and middle regions are both brittle-ductile mixed fracture mode,the thermal cycles still contributed to an improvement in tensile ductility.
文摘Plant roots are widely known to provide mechanical reinforcement to soils against shearing and further increase slope stability.However,whether roots provide reinforcement to loess cyclic re-sistance and how various factors affect roots reinforcement during seismic loading have rarely been studied.The objective is to conduct a series of cyclic direct simple shear tests and DEM numerical simulation to investigate the cyclic behaviour of rooted loess.The effects of initial static shear stress and loading frequency on the cyclic resistance of root-soil composites were first investigated.After that,cyclic direct simple shear simulations at constant volume were carried out based on the discrete element method(PFC^(3D))to investigate the effects of root geome-try,mechanical traits and root-soil bond strength on the cyclic strength of rooted loess.It was discovered that the roots could effectively improve the cyclic resistance of loess.The cyclic resistance of the root-soil composite decreases with the increase of the initial shear stress,then increases,and improves with the increase of the frequency.The simulation result show that increases in root elastic modulus and root-soil interfacial bond strength can all enhance the cyclic resistance of root-soil composites,and the maximum cyclic resistance of the root-soil composite was obtained when the initial inclination angle of the root system was 90°.
文摘A simple graph G on n vettices is said to be a simple MCD-graph if G has no two cyties having the same length and has the maximum possible number of edges.Two results of the number of cy cles in G are given by introdueing the Concept of a path decomposition and by them,the following theorem is proved:If G is a simple MCD-graph,then G is not a 2-connected planar graph and for all n except seven integer,G is not a 2-connected graph on n vertices containing a subgraph homeomor phic to K_4.
基金supported by the National Key Research and Development Program of China (No. 2018YFB1106302)the National Natural Science Foundation of China (Grant No. 51475380)the Aeronautical Science Foundation of China (Grant No. 2016ZE53)
文摘Thin-wall structures of Ti-6A1-4V were fabricated by low-power pulsed laser directed energy deposition. During deposition, consistent with prior reports, columnar grains were observed which grew from the bottom toward the top of melt pool tail. This resulted in a microstructure mainly composed of long and thin prior epitaxial β columnar grains (average width ^200μm). A periodic pattern in epitaxial growth of grains was observed, which was shown to depend upon laser traverse direction. Utilizing this, a novel means was proposed to determine accurately the fusion boundary of each deposited layer by inspection of the periodic wave patterns. As a result it was applied to investigate the influence of thermal cycling on microstructure evolution. Results showed that acicular martensite,α' phase, and a small amount of Widmanstatten, a laths, gradually converted to elongated acicular a and a large fraction of Widmanstatten a laths under layer-wise thermal cycling. Tensile tests showed that the yield strength, ultimate tensile strength and elongation of Ti-6Al-4V thin wall in the build direction were 9.1 %, 17.3% and 42% higher respectively than those typically observed in forged solids of the same alloy. It also showed the yield strength and ultimate tensile strength of the transverse tensile samples both were 13.3% higher than those from the build direction due to the strengthening effect of a large number of vertical β grain boundaries, but the elongation was 69.7% lower than that of the build direction due to the uneven grain deformation of β grains.
文摘Cell cycle regulation and brain injury:Traumatic brain injury(TBI)is one of the primary causes of morbidity and mortality in patients,and it affects more than 1.7 million Americans each year.Other than direct damage resulting from TBI,the brain injury triggers several secondary mechanisms which either individually or in combination contribute to the neurological deficits after TBI(Gupta and Sen,2016).These secondary mechanisms include neuronal death and stimulate proliferation of astrocytes and microglial cells,which in turn triggers neuro-inflammation(Simon et al.,2017).
基金supported by grants from the Alicia Koplowitz Foundation, the Valencian government (No. Prometeo II/2014/ 029 to V.R.)the Spanish government (Nos. BFU2011-30407 to V.R., BFU2012-30770 to J.G. and a FPU fellowship to C.D.-F.)the Swiss National Science Foundation (No. 310030_127184 to J.H.)
文摘Carbamoyl phosphate synthetase i （CPS1） deficiency （CPS1D） is an inborn error of the urea cycle having autosomal （2q34） recessive inheritance that can cause hyperammonemia and neonatal death or mental retardation. We analyzed the effects on CPS1 activity, kinetic parameters and enzyme stability of missense mutations reported in patients with CPS1 deficiency that map in the 20-kDa C-terminal domain of the enzyme. This domain turns on or off the enzyme depending on whether the essential allosteric activator of CPS 1, N-acetyl- L-glutamate （NAG）, is bound or is not bound to it. To carry out the present studies, we exploited a novel system that allows the expression in vitro and the purification of human CPS1, thus permitting site-directed mutagenesis. These studies have clarified disease causation by individual mutations, identifying functionally important residues, and revealing that a number of mutations decrease the affinity of the enzyme for NAG. Patients with NAG affinity-decreasing mutations might benefit from NAG site saturation therapy with N-carbamyl-L- glutamate （a registered drug, the analog of NAG）. Our results, together with additional present and prior site-directed mutagenesis data for other residues mapping in this domain, suggest an NAG-triggered conformational change in the 134-~4 loop of the C-terminal domain of this enzyme. This change might be an early event in the NAG activation process. Molecular dynamics simulations that were restrained according to the observed effects of the mutations are consistent with this hypothesis, providing further backing for this structurally plausible signaling mechanism by which NAG could trigger urea cycle activation via CPS1.
基金the National Key Technologies Research and Development Program of China(Grant No.2016YFB1100200)。
文摘Direct laser deposition(DLD),as a popular metal additive manufacturing process,shows advantages of technical flexibility and high efficiency to gain a high-performance alloy steel component.However,during the processing of DLD,the deposited steel layer is affected by the subsequent layer depositing.The DLD block shows different microstructure and mechanical properties at the bottom,middle and top of the deposited parts.To date,there are few research works about the effects of inter-layer interval time and laser power on the microstructure evolution and mechanical properties of the deposited layers.In this study,the idle time and laser power layer by layer during DLD of 12CrNi2 steel were controlled to cause the deposited layers to maintain a high cooling rate,while the bottom deposited layer was subjected to a weak tempering effect.Results show that a high proportion of martensite is produced,which improves the strength of the deposited layer.Under the laser scanning strategy of laser power 2,500 W,scanning velocity 5 mm·s^(-1),powder feeding rate 11 g·min^(-1),overlap rate 50%,and a laser power difference of 50 W and a 2 min interval,the tensile strength of the deposited layer of 12CrNi2 steel is in the range of 873-1,022 MPa,and the elongation is in the range of 16.2%-18.9%.This study provides a method to reduce the tempering effect of the subsequent deposition layers on the bottom layers,which can increase the proportion of martensite in the low-alloy high-strength steel,so as to improve the yield strength of the alloy steel.
基金co-supported by the National Science and Technology Major Project,China(No.J2019-I-0015-0014)the National Natural Science Foundation of China(No.52372397).
文摘To design the optimum acceleration control schedule for the Adaptive Cycle Engine(ACE)in the full flight envelope,this paper establishes a direct simulation model of the ACE transient state.In this model,geometric parameters are used to replace the component state parameters.The corresponding relationship between geometric parameters and component state parameters is determined by sensitivity analysis.The geometric variables are controlled when the geometric adjustment speed exceeds the limit,and at the same time the corresponding component state parameters are iterated.The gradient optimization algorism is used to optimize the ground acceleration process of ACE,and the control schedule in terms of operating point of compression components and corrected acceleration rate is used as the full-envelope acceleration control schedule based on the similarity principle.The acceleration control schedules of the triple-bypass mode and the double-bypass mode are designed in this paper.The acceleration processes under various flight conditions are simulated using the acceleration control schedules.Compared with the acceleration process with the linear geometric adjustment schedule,the acceleration performance of ACE is improved by the acceleration control schedule,with the impulse of the acceleration process of the triple-bypass mode being increased by 8.7%-12.3% and the impulse of the double-bypass mode acceleration process being increased by 11.8%-14.1%.
基金supported by the National Natural Science Foundation of China (Grant Nos.10734130,10935002,and 11075105)the National Basic Research Program of China (Grant No.2009GB105002)
文摘Within the framework of plane-wave angular spectrum analysis of the electromagnetic field structure, a solution valid for tightly focused radially polarized few-cycle laser pulses propagating in vacuum is presented. The resulting field distribution is significantly different from that based on the paraxial approximation for pulses with either small or large beam diameters. We compare the electron accelerations obtained with the two solutions and find that the energy gain obtained with our new solution is usually much larger than that with the paraxial approximation solution.
文摘Complement is a typical feature of Chinese grammar, and it seldom appears in other languages. Because of its complexity, it is very difficult for Chinese learners all over the world. The paper takes seven groups of simple directional complement （SDC）, ＂V-Shang＂, ＂V-Xia＂, ＂V-Jin＂, ＂V-Chu＂, ＂V-Kai＂, ＂V-Qi＂, and ＂V-Hui＂, as research goals. The investigation on second language acquisition （SLA） is carried out in terms of different native languages. The conclusion can be drawn that native language has a close relationship with SLA, because of their difference in Semantic Incorporation. In addition, the category of SDC is also an important factor influencing SLA.
