Three new ent-kaurane diterpenoids,silvaticusins A-C(1-3),along with a new ent-kaurane dimer silvaticusin D(4)were isolated from the aerial parts of Isodon silvaticus.The structures of these new compounds were establi...Three new ent-kaurane diterpenoids,silvaticusins A-C(1-3),along with a new ent-kaurane dimer silvaticusin D(4)were isolated from the aerial parts of Isodon silvaticus.The structures of these new compounds were established mainly by comprehensive analysis of their NMR and MS data.The absolute configuration of compounds 1 and 4 were determined using a single-crystal X-ray diffraction and computational methods,respectively.Compounds 2 and 3 were found to exhibit remarkable cytotoxic effects against five human tumor cell lines(HL-60,A-549,SMMC-7721,MDA-MB-231,and SW-480),with IC_(50) values spanning from 1.27±0.08 to 7.52±0.33μM.展开更多
基金supported by the National Science Fund for Distinguished Young Scholars(82325047)Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502)+1 种基金NSFC-Joint Foundation of Yunnan Province(U2002221)Youth Innovation Promotion Association CAS(2023409).
文摘Three new ent-kaurane diterpenoids,silvaticusins A-C(1-3),along with a new ent-kaurane dimer silvaticusin D(4)were isolated from the aerial parts of Isodon silvaticus.The structures of these new compounds were established mainly by comprehensive analysis of their NMR and MS data.The absolute configuration of compounds 1 and 4 were determined using a single-crystal X-ray diffraction and computational methods,respectively.Compounds 2 and 3 were found to exhibit remarkable cytotoxic effects against five human tumor cell lines(HL-60,A-549,SMMC-7721,MDA-MB-231,and SW-480),with IC_(50) values spanning from 1.27±0.08 to 7.52±0.33μM.
