1 Researchers have discovered the remains of ancient cities located above the ancient Silk Road in the rocky mountains of southeastern Uzbekistan.The groundbreaking discovery,made possible by new drone‑based lidar(激...1 Researchers have discovered the remains of ancient cities located above the ancient Silk Road in the rocky mountains of southeastern Uzbekistan.The groundbreaking discovery,made possible by new drone‑based lidar(激光雷达)technology,challenges long‑held assumptions that urban life was rarely seen in the remote mountains of Central Asia.展开更多
On the afternoon of May 30,the parallel forum"Global Dialogue on Civilisational Inheritance and the Digital Silk Road,"as part of the 4th Dialogue on Exchanges and Mutual Learning among Civilisations,was hel...On the afternoon of May 30,the parallel forum"Global Dialogue on Civilisational Inheritance and the Digital Silk Road,"as part of the 4th Dialogue on Exchanges and Mutual Learning among Civilisations,was held in Dunhuang.The forum focused on key areas of Silk Road civilisation studies in the new era under the theme"Carrying Forward the Silk Road Spirit and Pooling Strength for the Implementation of the Global Civilisation Initiative."Discussions centred on topics such as humanistic research on the Digital Silk Road,translation studies of cultural heritage,and archaeological studies of Silk Road sites,providing a platform for experts and scholars to exchange ideas and share achievements,and working to build a strong synergy for exchanges and mutual learning among civilisations.展开更多
The domesticated silkworm(Bombyx mori)has evolved a highly efficient nitrogen utilization system to support silk production.The silk glands play a pleiotropic role in sequestering nitrogen resources for silk synthesis...The domesticated silkworm(Bombyx mori)has evolved a highly efficient nitrogen utilization system to support silk production.The silk glands play a pleiotropic role in sequestering nitrogen resources for silk synthesis,mitigating aminoacidemia by assimilating free amino acids,and reallocating nitrogen during metamorphosis through programmed cell death.However,the specific functions of nitrogen metabolism-related genes in this process remain unclear.Using CRISPR/Cas9-based gene editing,mutations were generated in glutamine synthetase(GS),glutamate synthetase(GOGAT),asparagine synthetase(AS),glutamate dehydrogenase(GDH)and glutamate oxaloacetate transaminase 1(GOT1).Disruption of GS,GOGAT,and AS consistently reduced silkworm cocoon and pupal weight and significantly down-regulated silk protein gene transcription,whereas GOT1 mutation had no such effect.GOGAT mutants exhibited abnormally enlarged silk glands,whereas GS and AS mutants showed delayed programmed cell death in the silk glands.In contrast,GOT1 mutants displayed normal silk gland morphology but were consistently smaller.Disruption of GS,GOGAT,and AS led to more extensive transcriptional changes,including altered expression of transcription factors in the silk glands,compared with GOT1 mutants.Both GS and GOGAT mutants exhibited up-regulation of AS and GDH,while only GOGAT mutants displayed elevated AS enzymatic activity,suggesting that GOGAT may compete with AS for glutamine in the silk glands to support silk protein synthesis.AS mutants showed significantly elevated GOT activity and up-regulation of several metabolic pathways,indicating that AS may functionally interact with GOT in regulating both silk gland development and programmed cell death during metamorphosis.展开更多
Chengdu,a city rich in history and culture,is a beacon of China’s storied past embracing a distinct postmodern vibe.As an important hub along the ancient Silk Road,it has long been a meeting point for di!erent civili...Chengdu,a city rich in history and culture,is a beacon of China’s storied past embracing a distinct postmodern vibe.As an important hub along the ancient Silk Road,it has long been a meeting point for di!erent civilizations,where ideas and cultures have exchanged and thrived.Driven by the vision of a community with a shared future for mankind in recent years,Chengdu scholars and media have opened their arms to the world,engaging in multilingual storytelling.These efforts share the warmth and goodwill of a city consistently ranked one of the happiest in China.Through consistent efforts,new insights have emerged—ideas and aspirations intended to be shared with readers both at home and abroad.展开更多
From June 4 to 17,2025,the Harmony Together for a Friendly Future-Exhibition of International Youth Photography,jointly hosted by China Center for International Culture and Tourism Exchanges(CCICTE)and China Cultural ...From June 4 to 17,2025,the Harmony Together for a Friendly Future-Exhibition of International Youth Photography,jointly hosted by China Center for International Culture and Tourism Exchanges(CCICTE)and China Cultural Center in Copenhagen,was successfully held at the China Cultural Center in Copenhagen.展开更多
From June 4 to 17,2025.the Harmony Together for Friendly future-Exhibition of International Youth Photography.jointly Hosted by China Center for International Culture and Tourism Exchanges(CCICTE) and China Cultural C...From June 4 to 17,2025.the Harmony Together for Friendly future-Exhibition of International Youth Photography.jointly Hosted by China Center for International Culture and Tourism Exchanges(CCICTE) and China Cultural Center in Copenhagen.展开更多
Heat stress,a major challenge in modern agriculture due to global warming,significantly reduces crop productivity.To mitigate its adverse effects on maize yield,it is crucial to understand the mechanisms by which heat...Heat stress,a major challenge in modern agriculture due to global warming,significantly reduces crop productivity.To mitigate its adverse effects on maize yield,it is crucial to understand the mechanisms by which heat stress impacts reproductive development.This study investigated the impact of heat stress during the 12th leaf(V12)stage,where silk development begins on grain yield formation,using heat-sensitive and heat-tolerant cultivars.Compared to pollen,silks were found to be more vulnerable to heat stress.Heat stress disrupted hormone balance and inhibited hormone signaling transduction pathways in silks,delaying silk emergence from bracts and reducing fertilization and grain yield.The heat-tolerant cultivar maintained silk growth by activating more response pathways,displaying faster hormone responses,and up-regulating hormones.Taken together,we propose that hormones play an essential role in silk development and later fertilization process.展开更多
Tendon adhesion,a prevalent complication affecting over 30%of patients after a tendon injury or surgery,results in joint stiffness and impaired mobility.Although current treatments facilitate tendon repair,they are of...Tendon adhesion,a prevalent complication affecting over 30%of patients after a tendon injury or surgery,results in joint stiffness and impaired mobility.Although current treatments facilitate tendon repair,they are often insufficient in preventing adhesions and promoting optimal healing outcomes.To address these challenges,we developed an oriented cryostructured silk fibroin bandage(OCSFB)using the directional freeze-casting methodology.In vitro studies demonstrated that OCSFB provided a favorable microenvironment for cell viability,proliferation,and alignment,concurrently upregulating the expression of tendon-specific genes.In a rat Achilles tendon model,OCSFB significantly reduced adhesion formation and improved tendon healing.RNA-seq analysis further revealed modulation of cell adhesion molecules,substantiating its role in tissue regeneration.The integration of silk fibroin biocompatibility with a unique microstructure that facilitates cellular adhesion and proliferation renders OCSFB a promising approach for mitigating tendon adhesions and improving repair outcomes,establishing it as a robust candidate for clinical application.展开更多
BACKGROUND Intraoperative determination of resection margin and adequate residual liver parenchyma are the key points of hepatectomy for the treatment of liver tumors.Intraoperative ultrasound and indocyanine green fl...BACKGROUND Intraoperative determination of resection margin and adequate residual liver parenchyma are the key points of hepatectomy for the treatment of liver tumors.Intraoperative ultrasound and indocyanine green fluorescence navigation are the most commonly used methods at present,but the technical barriers limit their promotion.AIM To evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver tumors.METHODS From September 2020 to January 2022,8 patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocar-cinoma,and gastric cancer liver metastasis were included in this study.All patients underwent 3D-LAST in precise resection of liver tumors.RESULTS All patients(8/8,100%)underwent the operation successfully without any complications.During the mean follow-up of 8.7 months,all patients survived without tumor recurrence.CONCLUSION In conclusion,the 3D-LAST is a safe and effective new method for liver intraop-erative navigation,which is practical and easy to promote.Core Tip:The aim of this study is to evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver tumors.Eight patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocarcinoma,and gastric cancer liver metastasis underwent the operation successfully without any complications.During the mean follow-up of 8.7 months,all patients survived without tumor recurrence.In conclusion,the 3D-LAST is a safe and effective new method for liver intraoperative navigation,which is practical and easy to promote.INTRODUCTION Hepatectomy is widely used for the treatment of liver tumors.In recent decades,the concept and practice of hepatectomy have developed from irregular,regular and anatomical to the current precise resection.Necessary assistive technologies have enabled these advances.Intraoperative ultrasound(IOUS)localization and indocyanine green(ICG)fluorescence imaging guidance are two frequently-used approaches for laparoscopic hepatectomy[1,2].IOUS is an invaluable auxiliary means widely accepted in surgery for real-time diagnostic information to determine resection range and navigate the surgical path[3].However,the major limitation of IOUS is the time cost during the procedure for paging the sono-graphers and the difficulty of deciphering two dimensional images[4].ICG is a non-toxic water-soluble fluorophore that reveals fluorescence under the near-infrared spectrum[5].Since liver tissue penetration is limited to 5 to 10 mm,that restricted the visualization of deeper tumors by ICG excitation,thereby interfering with its application in laparoscopic hepatectomy[6].IOUS and ICG navigation require specific technical equipment,making implementation difficult in many centers.And these techniques will significantly increase the operation time.Three-dimensional(3D)visualization involves extracting features and producing volumetric images based on computed tomography(CT)through a computer postprocessing technique.This tool offers a reasonable approach to the clinical decision for the potential to display the complex internal anatomy in an intuitive and stereoscopic manner[7].In the past few decades,applying 3D simulation software for liver volume calculation,virtual simulation surgery,portal hypertension monitor,and surgical navigation has proven to be safe and effective[8].Therefore,we propose a new method to find obvious anatomical markers and calculate the resection range according to 3D positioning before operation.During the operation,the scope of resection was delineated with silk thread,and resection was performed.This is a new practical approach,which we named as 3D location approach with silk thread(3D-LAST).RESULTS During the study period from September 2020 to January 2022,5 patients with hepatocellular carcinoma,1 patient with intrahepatic cholangiocarcinoma,1 patient with hilar cholangiocarcinoma,and 1 patient with gastric cancer liver metastasis were assessed for liver resection.There were 5 males and 3 females.The mean age of these patients was 54.3±10.2 years(34-66 years).Preoperative 3D positioning was conducted and the scope of resection was delineated with a surgical suture successfully performed in all 8 patients without complications.The treatment results of these 8 patients are shown in Table 1.The 90-day operative mortality was zero.Complications worse than Dindo-Clavien IIIa was not observed at a mean follow-up time of 8.7 months(4-16 months),there was no evidence of tumor recurrence or extrahepatic metastasis.At the time of reporting,the patients are all alive and lead normal lives.We take one patient as an example,58-year-old male,who found a liver lesion 10 months after gastric cancer surgery.Enhanced CT showed that the lesion was located in the liver S5,about 1.5 cm in diameter,and considered metastatic lesions.We performed 3D-LAST guided hepatectomy on this patient(Figure 1).Other representative 3D-LAST surgical procedures are shown in Figure 2.展开更多
Flexible and conformable nanomaterial-based functional hydrogels find promising applications in various fields.However,the controllable manipulation of functional electron/mass transport networks in hydrogels remains ...Flexible and conformable nanomaterial-based functional hydrogels find promising applications in various fields.However,the controllable manipulation of functional electron/mass transport networks in hydrogels remains rather challenging to realize.We describe a general and versatile surfactant-free emulsion construction strategy to customize robust functional hydrogels with programmable hierarchical structures.Significantly,the amphipathy of silk fibroin(SF)and the reinforcement effect of MXene nanosheets produce sable Pickering emulsion without any surfactant.The followed microphase separation and self-cross-linking of the SF chains induced by the solvent exchange convert the composite emulsions into high-performance hydrogels with tunable microstructures and functionalities.As a proof-of-concept,the controllable regulation of the ordered conductive network and the water polarization effect confer the hydrogels with an intriguing electromagnetic interference shielding efficiency(~64 dB).Also,the microstructures of functional hydrogels are modulated to promote mass/heat transfer properties.The amino acids of SF and the surface terminations of MXene help reduce the enthalpy of water evaporation and the hierarchical structures of the hydrogels accelerate evaporation process,expecting far superior evaporation performance(~3.5 kg m^(-2)h^(-1))and salt tolerance capability compared to other hydrogel evaporators.Our findings open a wealth of opportunities for producing functional hydrogel devices with integrated structure-dependent properties.展开更多
Inspired by Marco Polo,the legendary explorer who journeyed to China along the ancient Silk Road over 700 years ago,Italian traveler Vienna Cammarota went on her own epic adventure.On April 26,2022,she set off from Ma...Inspired by Marco Polo,the legendary explorer who journeyed to China along the ancient Silk Road over 700 years ago,Italian traveler Vienna Cammarota went on her own epic adventure.On April 26,2022,she set off from Marco Polo's birthplace,Venice,with nothing but a simple backpack and two trekking poles.Now,at 74 years old,she has already walked over 20,000 kilometers through dozens of countries.展开更多
Ionogels have demonstrated substantial applications in smart wearable systems,soft robotics,and biomedical engineering due to the exceptional ionic conductivity and optical transparency.However,achieving ionogels with...Ionogels have demonstrated substantial applications in smart wearable systems,soft robotics,and biomedical engineering due to the exceptional ionic conductivity and optical transparency.However,achieving ionogels with desirable mechanical properties,environmental stability,and multi-mode sensing remains challenging.Here,we propose a simple strategy for the fabrication of multifunctional silk fabric-based ionogels(BSFIGs).The resulting fabric ionogels exhibits superior mechanical properties,with high tensile strength(11.3 MPa)and work of fracture(2.53 MJ/m^(3)).And its work of fracture still has 1.42 MJ/m^(3)as the notch increased to 50%,indicating its crack growth insensitivity.These ionogels can be used as sensors for strain,temperature,and tactile multimode sensing,demonstrating a gauge factor of 1.19 and a temperature coefficient of resistance of3.17/℃^(-1).Furthermore,these ionogels can be used for the detection of different roughness and as touch screens.The ionogels also exhibit exceptional optical transmittance and environmental stability even at80℃.Our scalable fabrication process broadens the application potential of these multifunctional ionogels in diverse fields,from smart systems to extreme environments.展开更多
The most beautiful interactions between civilisations are exchanges,integration,mutual learning,mutual reflection and mutual achievement.From 29th to 31st May,the 4th Dialogue on Exchanges and Mutual Learning among Ci...The most beautiful interactions between civilisations are exchanges,integration,mutual learning,mutual reflection and mutual achievement.From 29th to 31st May,the 4th Dialogue on Exchanges and Mutual Learning among Civilisations was held in Dunhuang,Gansu Province.During the event,the delegates visited places such as the city of Dunhuang and Jiayuguan,the pearl of the Gobi Desert.Through these visits,they experienced the coexistence of ancient and contemporary civilisations,gained insights into the Chinese civilisation's long history,openness,inclusiveness,and creative development,and felt the vitality of Chinese modernisation.展开更多
In an industrial park in Chonburi Province,about one-hour drive from the Thai capital of Bangkok,robotic arms on production lines move up and down,material-handling robots carrying components shuttle back and forth,an...In an industrial park in Chonburi Province,about one-hour drive from the Thai capital of Bangkok,robotic arms on production lines move up and down,material-handling robots carrying components shuttle back and forth,and Ferris wheel-shaped overhead tracks transport semi-finished products to the next destination.A factory equipped with a dedicated 5G network glows with automation,digitization,and intelligence.This is a fruit of China-Thailand cooperation on the digital economy.In recent years,Thailand’s digital economy has achieved rapid development with an average annual growth rate exceeding 15 percent,making it a star performer in Southeast Asia’s digital transformation.Chinese technology and solutions have played a pivotal role in this process.展开更多
In the thousand-year-old mural of Mogao Grottoes in Dunhuang,a special symbol tells the story of exchanges among civilisations.Three Rabbits Sharing Three Ears depicts three rabbits chasing each other,with each two sh...In the thousand-year-old mural of Mogao Grottoes in Dunhuang,a special symbol tells the story of exchanges among civilisations.Three Rabbits Sharing Three Ears depicts three rabbits chasing each other,with each two sharing one ear.It is said that its earliest version appeared in Dunhuang in the 6th century,and it had travelled across the desert along the ancient Silk Road,over mountains and rivers,leaping onto British ceramic tiles,integrating into Egyptian pottery and jumping cross the clock faces of German churches.展开更多
Gas-liquid interfacial films have emerged as versatile materials for surface modification in biomedical applications,agriculture,and antifouling owing to their strong substrate-bonding capabilities.Silk nanofibrils(SN...Gas-liquid interfacial films have emerged as versatile materials for surface modification in biomedical applications,agriculture,and antifouling owing to their strong substrate-bonding capabilities.Silk nanofibrils(SNF),as nanoscale building blocks of silk,exhibit exceptional mechanical stability,high crystallinity,and aqueous adaptability,making them ideal candidates for fabricating interfacial films.However,conventional fabrication methods for SNF-or protein-based interfacial films often involve complex and resource-intensive chemical processes.To overcome these challenges,this study introduces a simple and efficient strategy for preparing thermally induced SNF gas-liquid interfacial films via heat treatment,leveraging thermal evaporation-induced concentration to drive self-assembly.The method demonstrated broad applicability to various proteins and hydrophilic substrates,offering versatility and sustainability.Furthermore,the prepared films exhibited potential as antifouling and anti-counterfeiting functional coatings,significantly expanding the application scenarios of protein-based interfacial films.展开更多
The Hong Kong Research Institute of Textiles and Apparel(hereinafter referred to as"HKRITA")and Seiko Epson Corporation(hereinafter referred to as"Epson")have succeeded in developing new regenerate...The Hong Kong Research Institute of Textiles and Apparel(hereinafter referred to as"HKRITA")and Seiko Epson Corporation(hereinafter referred to as"Epson")have succeeded in developing new regenerated cellulose fiber with a silk-like sheen from waste cotton fabric through a new production process.A movement toward using fibers recycled from discarded clothing has been gaining momentum,driven by a growing recognition of waste clothing as a global environmental issue.In Europe in particular,a move is under way to use more regenerated fiber and reduce textile waste.展开更多
On April 6th,the"Silk Road People-to-People Connectivity"China-Cambodia Traditional Instrument Concert was successfully held in Phnom Penh.The event was attended by Li Ji,Cultural Counsellor of the Chinese E...On April 6th,the"Silk Road People-to-People Connectivity"China-Cambodia Traditional Instrument Concert was successfully held in Phnom Penh.The event was attended by Li Ji,Cultural Counsellor of the Chinese Embassy in Cambodia,officials from Ministry of Culture and Fine Arts of Cambodia and Ministry of Commerce of Cambodia,along with vips from various sectors.展开更多
文摘1 Researchers have discovered the remains of ancient cities located above the ancient Silk Road in the rocky mountains of southeastern Uzbekistan.The groundbreaking discovery,made possible by new drone‑based lidar(激光雷达)technology,challenges long‑held assumptions that urban life was rarely seen in the remote mountains of Central Asia.
文摘On the afternoon of May 30,the parallel forum"Global Dialogue on Civilisational Inheritance and the Digital Silk Road,"as part of the 4th Dialogue on Exchanges and Mutual Learning among Civilisations,was held in Dunhuang.The forum focused on key areas of Silk Road civilisation studies in the new era under the theme"Carrying Forward the Silk Road Spirit and Pooling Strength for the Implementation of the Global Civilisation Initiative."Discussions centred on topics such as humanistic research on the Digital Silk Road,translation studies of cultural heritage,and archaeological studies of Silk Road sites,providing a platform for experts and scholars to exchange ideas and share achievements,and working to build a strong synergy for exchanges and mutual learning among civilisations.
基金supported by the National Natural Science Foundation of China(32270458,32070411,2023A1515010657)State Key Laboratory of Resource Insects(SKLSGB-ORP202209)。
文摘The domesticated silkworm(Bombyx mori)has evolved a highly efficient nitrogen utilization system to support silk production.The silk glands play a pleiotropic role in sequestering nitrogen resources for silk synthesis,mitigating aminoacidemia by assimilating free amino acids,and reallocating nitrogen during metamorphosis through programmed cell death.However,the specific functions of nitrogen metabolism-related genes in this process remain unclear.Using CRISPR/Cas9-based gene editing,mutations were generated in glutamine synthetase(GS),glutamate synthetase(GOGAT),asparagine synthetase(AS),glutamate dehydrogenase(GDH)and glutamate oxaloacetate transaminase 1(GOT1).Disruption of GS,GOGAT,and AS consistently reduced silkworm cocoon and pupal weight and significantly down-regulated silk protein gene transcription,whereas GOT1 mutation had no such effect.GOGAT mutants exhibited abnormally enlarged silk glands,whereas GS and AS mutants showed delayed programmed cell death in the silk glands.In contrast,GOT1 mutants displayed normal silk gland morphology but were consistently smaller.Disruption of GS,GOGAT,and AS led to more extensive transcriptional changes,including altered expression of transcription factors in the silk glands,compared with GOT1 mutants.Both GS and GOGAT mutants exhibited up-regulation of AS and GDH,while only GOGAT mutants displayed elevated AS enzymatic activity,suggesting that GOGAT may compete with AS for glutamine in the silk glands to support silk protein synthesis.AS mutants showed significantly elevated GOT activity and up-regulation of several metabolic pathways,indicating that AS may functionally interact with GOT in regulating both silk gland development and programmed cell death during metamorphosis.
文摘Chengdu,a city rich in history and culture,is a beacon of China’s storied past embracing a distinct postmodern vibe.As an important hub along the ancient Silk Road,it has long been a meeting point for di!erent civilizations,where ideas and cultures have exchanged and thrived.Driven by the vision of a community with a shared future for mankind in recent years,Chengdu scholars and media have opened their arms to the world,engaging in multilingual storytelling.These efforts share the warmth and goodwill of a city consistently ranked one of the happiest in China.Through consistent efforts,new insights have emerged—ideas and aspirations intended to be shared with readers both at home and abroad.
文摘From June 4 to 17,2025,the Harmony Together for a Friendly Future-Exhibition of International Youth Photography,jointly hosted by China Center for International Culture and Tourism Exchanges(CCICTE)and China Cultural Center in Copenhagen,was successfully held at the China Cultural Center in Copenhagen.
文摘From June 4 to 17,2025.the Harmony Together for Friendly future-Exhibition of International Youth Photography.jointly Hosted by China Center for International Culture and Tourism Exchanges(CCICTE) and China Cultural Center in Copenhagen.
基金supported by the National Natural Science Foundation of China(32071959)the National Key Research and Development Program of China(2023YFD2303304)+1 种基金the Key Research and Development Program of Shandong Province(LJNY202103)the Shandong Province Key Agricultural Project for Application Technology Innovation(SDAIT02-08)to Peng Liu.
文摘Heat stress,a major challenge in modern agriculture due to global warming,significantly reduces crop productivity.To mitigate its adverse effects on maize yield,it is crucial to understand the mechanisms by which heat stress impacts reproductive development.This study investigated the impact of heat stress during the 12th leaf(V12)stage,where silk development begins on grain yield formation,using heat-sensitive and heat-tolerant cultivars.Compared to pollen,silks were found to be more vulnerable to heat stress.Heat stress disrupted hormone balance and inhibited hormone signaling transduction pathways in silks,delaying silk emergence from bracts and reducing fertilization and grain yield.The heat-tolerant cultivar maintained silk growth by activating more response pathways,displaying faster hormone responses,and up-regulating hormones.Taken together,we propose that hormones play an essential role in silk development and later fertilization process.
基金sponsored by the National Natural Science Foundation of China(Nos.52235007,T2121004,and 52325504)the Key R&D Program of Zhejiang(No.2024SSYS0027)+1 种基金the National Key Research and Development Program of China(Nos.2024YFB4607700 and 2024YFB4607703)the China National Postdoctoral Program for Innovative Talents(No.BX20240312)。
文摘Tendon adhesion,a prevalent complication affecting over 30%of patients after a tendon injury or surgery,results in joint stiffness and impaired mobility.Although current treatments facilitate tendon repair,they are often insufficient in preventing adhesions and promoting optimal healing outcomes.To address these challenges,we developed an oriented cryostructured silk fibroin bandage(OCSFB)using the directional freeze-casting methodology.In vitro studies demonstrated that OCSFB provided a favorable microenvironment for cell viability,proliferation,and alignment,concurrently upregulating the expression of tendon-specific genes.In a rat Achilles tendon model,OCSFB significantly reduced adhesion formation and improved tendon healing.RNA-seq analysis further revealed modulation of cell adhesion molecules,substantiating its role in tissue regeneration.The integration of silk fibroin biocompatibility with a unique microstructure that facilitates cellular adhesion and proliferation renders OCSFB a promising approach for mitigating tendon adhesions and improving repair outcomes,establishing it as a robust candidate for clinical application.
文摘BACKGROUND Intraoperative determination of resection margin and adequate residual liver parenchyma are the key points of hepatectomy for the treatment of liver tumors.Intraoperative ultrasound and indocyanine green fluorescence navigation are the most commonly used methods at present,but the technical barriers limit their promotion.AIM To evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver tumors.METHODS From September 2020 to January 2022,8 patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocar-cinoma,and gastric cancer liver metastasis were included in this study.All patients underwent 3D-LAST in precise resection of liver tumors.RESULTS All patients(8/8,100%)underwent the operation successfully without any complications.During the mean follow-up of 8.7 months,all patients survived without tumor recurrence.CONCLUSION In conclusion,the 3D-LAST is a safe and effective new method for liver intraop-erative navigation,which is practical and easy to promote.Core Tip:The aim of this study is to evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver tumors.Eight patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocarcinoma,and gastric cancer liver metastasis underwent the operation successfully without any complications.During the mean follow-up of 8.7 months,all patients survived without tumor recurrence.In conclusion,the 3D-LAST is a safe and effective new method for liver intraoperative navigation,which is practical and easy to promote.INTRODUCTION Hepatectomy is widely used for the treatment of liver tumors.In recent decades,the concept and practice of hepatectomy have developed from irregular,regular and anatomical to the current precise resection.Necessary assistive technologies have enabled these advances.Intraoperative ultrasound(IOUS)localization and indocyanine green(ICG)fluorescence imaging guidance are two frequently-used approaches for laparoscopic hepatectomy[1,2].IOUS is an invaluable auxiliary means widely accepted in surgery for real-time diagnostic information to determine resection range and navigate the surgical path[3].However,the major limitation of IOUS is the time cost during the procedure for paging the sono-graphers and the difficulty of deciphering two dimensional images[4].ICG is a non-toxic water-soluble fluorophore that reveals fluorescence under the near-infrared spectrum[5].Since liver tissue penetration is limited to 5 to 10 mm,that restricted the visualization of deeper tumors by ICG excitation,thereby interfering with its application in laparoscopic hepatectomy[6].IOUS and ICG navigation require specific technical equipment,making implementation difficult in many centers.And these techniques will significantly increase the operation time.Three-dimensional(3D)visualization involves extracting features and producing volumetric images based on computed tomography(CT)through a computer postprocessing technique.This tool offers a reasonable approach to the clinical decision for the potential to display the complex internal anatomy in an intuitive and stereoscopic manner[7].In the past few decades,applying 3D simulation software for liver volume calculation,virtual simulation surgery,portal hypertension monitor,and surgical navigation has proven to be safe and effective[8].Therefore,we propose a new method to find obvious anatomical markers and calculate the resection range according to 3D positioning before operation.During the operation,the scope of resection was delineated with silk thread,and resection was performed.This is a new practical approach,which we named as 3D location approach with silk thread(3D-LAST).RESULTS During the study period from September 2020 to January 2022,5 patients with hepatocellular carcinoma,1 patient with intrahepatic cholangiocarcinoma,1 patient with hilar cholangiocarcinoma,and 1 patient with gastric cancer liver metastasis were assessed for liver resection.There were 5 males and 3 females.The mean age of these patients was 54.3±10.2 years(34-66 years).Preoperative 3D positioning was conducted and the scope of resection was delineated with a surgical suture successfully performed in all 8 patients without complications.The treatment results of these 8 patients are shown in Table 1.The 90-day operative mortality was zero.Complications worse than Dindo-Clavien IIIa was not observed at a mean follow-up time of 8.7 months(4-16 months),there was no evidence of tumor recurrence or extrahepatic metastasis.At the time of reporting,the patients are all alive and lead normal lives.We take one patient as an example,58-year-old male,who found a liver lesion 10 months after gastric cancer surgery.Enhanced CT showed that the lesion was located in the liver S5,about 1.5 cm in diameter,and considered metastatic lesions.We performed 3D-LAST guided hepatectomy on this patient(Figure 1).Other representative 3D-LAST surgical procedures are shown in Figure 2.
基金support from the National Natural Science Foundation of China(Nos.51922020,52273064 and 52221006)the Fundamental Research Funds for the Central Universities(BHYC1707B)is gratefully acknowledged.
文摘Flexible and conformable nanomaterial-based functional hydrogels find promising applications in various fields.However,the controllable manipulation of functional electron/mass transport networks in hydrogels remains rather challenging to realize.We describe a general and versatile surfactant-free emulsion construction strategy to customize robust functional hydrogels with programmable hierarchical structures.Significantly,the amphipathy of silk fibroin(SF)and the reinforcement effect of MXene nanosheets produce sable Pickering emulsion without any surfactant.The followed microphase separation and self-cross-linking of the SF chains induced by the solvent exchange convert the composite emulsions into high-performance hydrogels with tunable microstructures and functionalities.As a proof-of-concept,the controllable regulation of the ordered conductive network and the water polarization effect confer the hydrogels with an intriguing electromagnetic interference shielding efficiency(~64 dB).Also,the microstructures of functional hydrogels are modulated to promote mass/heat transfer properties.The amino acids of SF and the surface terminations of MXene help reduce the enthalpy of water evaporation and the hierarchical structures of the hydrogels accelerate evaporation process,expecting far superior evaporation performance(~3.5 kg m^(-2)h^(-1))and salt tolerance capability compared to other hydrogel evaporators.Our findings open a wealth of opportunities for producing functional hydrogel devices with integrated structure-dependent properties.
文摘Inspired by Marco Polo,the legendary explorer who journeyed to China along the ancient Silk Road over 700 years ago,Italian traveler Vienna Cammarota went on her own epic adventure.On April 26,2022,she set off from Marco Polo's birthplace,Venice,with nothing but a simple backpack and two trekking poles.Now,at 74 years old,she has already walked over 20,000 kilometers through dozens of countries.
基金supported by the National Natural Science Foundation of China(No.12302192)the Fundamental Research Funds for the Central Universities(No.SWU-KQ22025)+4 种基金the Science and Technology Research Program of Chongqing Municipal Education Commission(No.KJQN202300222)Natural Science Foundation of Chongqing(No.cstc2021jcyj-msxmX0241)the Fund for Innovative Research Groups of Natural Science Foundation of Hebei Province(No.A2024202045)Key Technologies and Demonstration Application Research Project for Large-scale Lithium-ion Hybrid Energy Storage Equipment(No.HC23118)Major Basic Research Project of Hebei Province Natural Science Foundation(No.A2023202049).
文摘Ionogels have demonstrated substantial applications in smart wearable systems,soft robotics,and biomedical engineering due to the exceptional ionic conductivity and optical transparency.However,achieving ionogels with desirable mechanical properties,environmental stability,and multi-mode sensing remains challenging.Here,we propose a simple strategy for the fabrication of multifunctional silk fabric-based ionogels(BSFIGs).The resulting fabric ionogels exhibits superior mechanical properties,with high tensile strength(11.3 MPa)and work of fracture(2.53 MJ/m^(3)).And its work of fracture still has 1.42 MJ/m^(3)as the notch increased to 50%,indicating its crack growth insensitivity.These ionogels can be used as sensors for strain,temperature,and tactile multimode sensing,demonstrating a gauge factor of 1.19 and a temperature coefficient of resistance of3.17/℃^(-1).Furthermore,these ionogels can be used for the detection of different roughness and as touch screens.The ionogels also exhibit exceptional optical transmittance and environmental stability even at80℃.Our scalable fabrication process broadens the application potential of these multifunctional ionogels in diverse fields,from smart systems to extreme environments.
文摘The most beautiful interactions between civilisations are exchanges,integration,mutual learning,mutual reflection and mutual achievement.From 29th to 31st May,the 4th Dialogue on Exchanges and Mutual Learning among Civilisations was held in Dunhuang,Gansu Province.During the event,the delegates visited places such as the city of Dunhuang and Jiayuguan,the pearl of the Gobi Desert.Through these visits,they experienced the coexistence of ancient and contemporary civilisations,gained insights into the Chinese civilisation's long history,openness,inclusiveness,and creative development,and felt the vitality of Chinese modernisation.
文摘In an industrial park in Chonburi Province,about one-hour drive from the Thai capital of Bangkok,robotic arms on production lines move up and down,material-handling robots carrying components shuttle back and forth,and Ferris wheel-shaped overhead tracks transport semi-finished products to the next destination.A factory equipped with a dedicated 5G network glows with automation,digitization,and intelligence.This is a fruit of China-Thailand cooperation on the digital economy.In recent years,Thailand’s digital economy has achieved rapid development with an average annual growth rate exceeding 15 percent,making it a star performer in Southeast Asia’s digital transformation.Chinese technology and solutions have played a pivotal role in this process.
文摘In the thousand-year-old mural of Mogao Grottoes in Dunhuang,a special symbol tells the story of exchanges among civilisations.Three Rabbits Sharing Three Ears depicts three rabbits chasing each other,with each two sharing one ear.It is said that its earliest version appeared in Dunhuang in the 6th century,and it had travelled across the desert along the ancient Silk Road,over mountains and rivers,leaping onto British ceramic tiles,integrating into Egyptian pottery and jumping cross the clock faces of German churches.
基金financially supported by the National Natural Science Foundation of China(No.21935002)。
文摘Gas-liquid interfacial films have emerged as versatile materials for surface modification in biomedical applications,agriculture,and antifouling owing to their strong substrate-bonding capabilities.Silk nanofibrils(SNF),as nanoscale building blocks of silk,exhibit exceptional mechanical stability,high crystallinity,and aqueous adaptability,making them ideal candidates for fabricating interfacial films.However,conventional fabrication methods for SNF-or protein-based interfacial films often involve complex and resource-intensive chemical processes.To overcome these challenges,this study introduces a simple and efficient strategy for preparing thermally induced SNF gas-liquid interfacial films via heat treatment,leveraging thermal evaporation-induced concentration to drive self-assembly.The method demonstrated broad applicability to various proteins and hydrophilic substrates,offering versatility and sustainability.Furthermore,the prepared films exhibited potential as antifouling and anti-counterfeiting functional coatings,significantly expanding the application scenarios of protein-based interfacial films.
文摘The Hong Kong Research Institute of Textiles and Apparel(hereinafter referred to as"HKRITA")and Seiko Epson Corporation(hereinafter referred to as"Epson")have succeeded in developing new regenerated cellulose fiber with a silk-like sheen from waste cotton fabric through a new production process.A movement toward using fibers recycled from discarded clothing has been gaining momentum,driven by a growing recognition of waste clothing as a global environmental issue.In Europe in particular,a move is under way to use more regenerated fiber and reduce textile waste.
文摘On April 6th,the"Silk Road People-to-People Connectivity"China-Cambodia Traditional Instrument Concert was successfully held in Phnom Penh.The event was attended by Li Ji,Cultural Counsellor of the Chinese Embassy in Cambodia,officials from Ministry of Culture and Fine Arts of Cambodia and Ministry of Commerce of Cambodia,along with vips from various sectors.
