Objective To observe the effects of low expressed Angiotensin-converting enzyme 2(Ace2) gene on senescence related signals of alveolar typeⅡepithelial cells in silicotic mice.Methods In March 2022,20 8-12W SPF male w...Objective To observe the effects of low expressed Angiotensin-converting enzyme 2(Ace2) gene on senescence related signals of alveolar typeⅡepithelial cells in silicotic mice.Methods In March 2022,20 8-12W SPF male wild-type C57BL/6 mice and 20 Ace2 gene knockdown mice(Ace2^(+/-),C57BL/6 background) were randomly divided into wild-type control group Ace2 low expression group,wild-type silicosis group,Ace2 low expression silicosis group,with 10 mice in each group.展开更多
Objective To screen the changes of microRNA(miRNA) expression profiles in lung tissues of early silicosis rats,and provide a basis for functional analysis of differential microRNA. Methods SPF Wistar male rats were ra...Objective To screen the changes of microRNA(miRNA) expression profiles in lung tissues of early silicosis rats,and provide a basis for functional analysis of differential microRNA. Methods SPF Wistar male rats were randomly divided into negative control group and SiO2-exposed groups,with 30 rats in each group.展开更多
文摘Objective To observe the effects of low expressed Angiotensin-converting enzyme 2(Ace2) gene on senescence related signals of alveolar typeⅡepithelial cells in silicotic mice.Methods In March 2022,20 8-12W SPF male wild-type C57BL/6 mice and 20 Ace2 gene knockdown mice(Ace2^(+/-),C57BL/6 background) were randomly divided into wild-type control group Ace2 low expression group,wild-type silicosis group,Ace2 low expression silicosis group,with 10 mice in each group.
文摘Objective To screen the changes of microRNA(miRNA) expression profiles in lung tissues of early silicosis rats,and provide a basis for functional analysis of differential microRNA. Methods SPF Wistar male rats were randomly divided into negative control group and SiO2-exposed groups,with 30 rats in each group.
