Significant wave period is an important parameter in coastal and offshore engineering design.Traditional spectral wave models do not directly calculate this parameter,which means that it needs to be estimated from the...Significant wave period is an important parameter in coastal and offshore engineering design.Traditional spectral wave models do not directly calculate this parameter,which means that it needs to be estimated from the spectral periods using empirical formulas.The wave energy period is one of the wave periods directly output by many wave models and is often used in studies of wave energy.This study investigated the relationship between significant wave period and wave energy period using wave data measured at three stations in the coastal waters of China.The observations recorded at these stations in the South China Sea,the East China Sea,and the Bohai Sea covered a wide range of surface wave conditions.Analysis indicated that the ratio of significant wave period to wave energy period is closely related to the Goda peakedness parameter of the wave spectra.Therefore,we proposed an empirical formula in which significant wave period is a function of wave energy period and the Goda peakedness parameter.Evaluation results showed that the performance of this formula is substantially better than that of fitting formulas that use constant coefficients.展开更多
BACKGROUND Clinically significant portal hypertension(CSPH)is a crucial prognostic deter-minant for liver-related events(LREs)in patients with compensated viral cir-rhosis.Liver stiffness measurement(LSM)-related mark...BACKGROUND Clinically significant portal hypertension(CSPH)is a crucial prognostic deter-minant for liver-related events(LREs)in patients with compensated viral cir-rhosis.Liver stiffness measurement(LSM)-related markers may help to predict the risk of LREs.AIM To evaluate the value of LSM and its composite biomarkers[LSM-platelet ratio(LPR),LSM-albumin ratio(LAR)]in predicting LREs.METHODS This study retrospectively enrolled compensated viral cirrhosis patients with CSPH.The Cox regression model was employed to examine the prediction of LSM,LPR,and LAR for LREs.The model performance was assessed through receiver operating characteristic,decision curve,and time-dependent area under the curve analysis.The Kaplan-Meier curve was used to evaluate the cumulative incidence of LREs,and further stratified analysis of different LREs was per-formed.RESULTS A total of 598 patients were included,and 319 patients(53.3%)developed LREs during follow-up.Multivariate proportional hazards modeling demonstrated that LSM,LPR,and LAR were independent predictors of LREs.LPR had better performance in predicting LREs than LAR and LSM(area under the curve=0.780,0.727,0.683,respectively,all P<0.05).The cumulative incidence of LREs in the high-risk group were significantly higher than that in the low-risk group(P<0.001).Among the different LREs,LPR was superior to LSM and LAR in predicting liver decompensation,while the difference in predicting hepatocellular carcinoma and liver-related death was relatively small.CONCLUSION LPR is superior to LSM and LAR in predicting LREs in compensated viral cirrhosis patients with CSPH,especially in predicting liver decompensation.展开更多
Liver biopsy is rarely performed for the diagnosis of compensated advanced chronic liver disease(cACLD)in the current clinical hepatology practice.In the early stage,cACLD presents without portal hypertension,and in t...Liver biopsy is rarely performed for the diagnosis of compensated advanced chronic liver disease(cACLD)in the current clinical hepatology practice.In the early stage,cACLD presents without portal hypertension,and in the later stage,it presents with portal hypertension.Hepatic venous pressure gradient measu-rement is the gold standard for diagnosing portal hypertension,but it is rarely used due to its invasive nature.The recent Baveno VII consensus recommends a noninvasive strategy for the diagnosis of cACLD and clinically significant portal hypertension(CSPH).However,there is some uncertainty regarding the dia-gnostic accuracy of Baveno VII criteria for predicting CSPH among patients with metabolic dysfunction-associated steatotic liver disease(MASLD).This is per-tinent as MASLD has become the most important cause of cACLD in the United States.This mini-review outlines the diagnostic performance of Baveno VII cri-teria and other noninvasive criteria for predicting CSPH in patients with cACLD from MASLD compared to non-MASLD causes.展开更多
在中国式现代化视域中,我国区域国别学学科建设的理论意义在于进一步繁荣和发展我国哲学社会科学,为中国式现代化提供有力知识支撑,实践意义在于为中国式现代化创建良好的周边、区域和全球环境。其建设路径需要以服务中国式现代化对外...在中国式现代化视域中,我国区域国别学学科建设的理论意义在于进一步繁荣和发展我国哲学社会科学,为中国式现代化提供有力知识支撑,实践意义在于为中国式现代化创建良好的周边、区域和全球环境。其建设路径需要以服务中国式现代化对外战略需求为导向,从国家层面完善区域国别学学科建设的顶层设计和战略谋划,高校层面则需要构建以学科属性为引领(Led by the Nature of the Discipline)、以在地化为主导(Led by Localization)、以国际视野为指向(Guided by an International Vision)和以师资队伍建设为中心(Centered on Faculty Team Building)的“LLGC”模式,为中国式现代化构筑区域国别学人才培养“蓄水池”。展开更多
基金The National Natural Science Foundation of China under contract No.41821004the Basic Scientific Fund for National Public Research Institutes of China under contract No.2020Q08the Fund of Laoshan Laboratory under contract No.LSKJ202201600.
文摘Significant wave period is an important parameter in coastal and offshore engineering design.Traditional spectral wave models do not directly calculate this parameter,which means that it needs to be estimated from the spectral periods using empirical formulas.The wave energy period is one of the wave periods directly output by many wave models and is often used in studies of wave energy.This study investigated the relationship between significant wave period and wave energy period using wave data measured at three stations in the coastal waters of China.The observations recorded at these stations in the South China Sea,the East China Sea,and the Bohai Sea covered a wide range of surface wave conditions.Analysis indicated that the ratio of significant wave period to wave energy period is closely related to the Goda peakedness parameter of the wave spectra.Therefore,we proposed an empirical formula in which significant wave period is a function of wave energy period and the Goda peakedness parameter.Evaluation results showed that the performance of this formula is substantially better than that of fitting formulas that use constant coefficients.
基金Supported by the High-Level Chinese Medicine Key Discipline Construction Project,No.zyyzdxk-2023005Capital’s Funds for Health Improvement and Research,No.2024-1-2173+2 种基金National Natural Science Foundation of China,No.82474419 and No.82474426Beijing Municipal Natural Science Foundation,No.7232272Beijing Traditional Chinese Medicine Technology Development Fund Project,No.BJZYZD-2023-12.
文摘BACKGROUND Clinically significant portal hypertension(CSPH)is a crucial prognostic deter-minant for liver-related events(LREs)in patients with compensated viral cir-rhosis.Liver stiffness measurement(LSM)-related markers may help to predict the risk of LREs.AIM To evaluate the value of LSM and its composite biomarkers[LSM-platelet ratio(LPR),LSM-albumin ratio(LAR)]in predicting LREs.METHODS This study retrospectively enrolled compensated viral cirrhosis patients with CSPH.The Cox regression model was employed to examine the prediction of LSM,LPR,and LAR for LREs.The model performance was assessed through receiver operating characteristic,decision curve,and time-dependent area under the curve analysis.The Kaplan-Meier curve was used to evaluate the cumulative incidence of LREs,and further stratified analysis of different LREs was per-formed.RESULTS A total of 598 patients were included,and 319 patients(53.3%)developed LREs during follow-up.Multivariate proportional hazards modeling demonstrated that LSM,LPR,and LAR were independent predictors of LREs.LPR had better performance in predicting LREs than LAR and LSM(area under the curve=0.780,0.727,0.683,respectively,all P<0.05).The cumulative incidence of LREs in the high-risk group were significantly higher than that in the low-risk group(P<0.001).Among the different LREs,LPR was superior to LSM and LAR in predicting liver decompensation,while the difference in predicting hepatocellular carcinoma and liver-related death was relatively small.CONCLUSION LPR is superior to LSM and LAR in predicting LREs in compensated viral cirrhosis patients with CSPH,especially in predicting liver decompensation.
文摘Liver biopsy is rarely performed for the diagnosis of compensated advanced chronic liver disease(cACLD)in the current clinical hepatology practice.In the early stage,cACLD presents without portal hypertension,and in the later stage,it presents with portal hypertension.Hepatic venous pressure gradient measu-rement is the gold standard for diagnosing portal hypertension,but it is rarely used due to its invasive nature.The recent Baveno VII consensus recommends a noninvasive strategy for the diagnosis of cACLD and clinically significant portal hypertension(CSPH).However,there is some uncertainty regarding the dia-gnostic accuracy of Baveno VII criteria for predicting CSPH among patients with metabolic dysfunction-associated steatotic liver disease(MASLD).This is per-tinent as MASLD has become the most important cause of cACLD in the United States.This mini-review outlines the diagnostic performance of Baveno VII cri-teria and other noninvasive criteria for predicting CSPH in patients with cACLD from MASLD compared to non-MASLD causes.
文摘在中国式现代化视域中,我国区域国别学学科建设的理论意义在于进一步繁荣和发展我国哲学社会科学,为中国式现代化提供有力知识支撑,实践意义在于为中国式现代化创建良好的周边、区域和全球环境。其建设路径需要以服务中国式现代化对外战略需求为导向,从国家层面完善区域国别学学科建设的顶层设计和战略谋划,高校层面则需要构建以学科属性为引领(Led by the Nature of the Discipline)、以在地化为主导(Led by Localization)、以国际视野为指向(Guided by an International Vision)和以师资队伍建设为中心(Centered on Faculty Team Building)的“LLGC”模式,为中国式现代化构筑区域国别学人才培养“蓄水池”。
