Dear Editor,Tumor-associated macrophages(TAMs)account for up to 50%of tumor mass and serve as key innate immune cells in the tumor microenvironment(Kzhyshkowska et al.,2024).TAMs are primarily M2-like phenotypes that ...Dear Editor,Tumor-associated macrophages(TAMs)account for up to 50%of tumor mass and serve as key innate immune cells in the tumor microenvironment(Kzhyshkowska et al.,2024).TAMs are primarily M2-like phenotypes that contribute to tumor immunosuppression and promote immune escape by secreting anti-inflammatory fac tors,thereby supporting tumor growth,metastasis,and angiogenesis.TAMs can be reprogrammed into M1-like phenotypes by immunostimulatory signals,promoting pro-inflammatory cytokines such as TNF-αand IL-12 that suppress tumor growth.展开更多
基金supported by the National Key R&D Program of China(2022YFA1205803)Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00040)+3 种基金Beijing Natural Science Foundation(7242277)Beijing Nova Program(Z201100006820110)of Beijing Municipal Science&Technology CommissionCAMS Innovation Fund for Medical Science(CIFMS 2024-I2M-TS-008,CIFMS 2021 I2M-1-006)the Fundamental Research Funds for the Central Universities(3332021100).
文摘Dear Editor,Tumor-associated macrophages(TAMs)account for up to 50%of tumor mass and serve as key innate immune cells in the tumor microenvironment(Kzhyshkowska et al.,2024).TAMs are primarily M2-like phenotypes that contribute to tumor immunosuppression and promote immune escape by secreting anti-inflammatory fac tors,thereby supporting tumor growth,metastasis,and angiogenesis.TAMs can be reprogrammed into M1-like phenotypes by immunostimulatory signals,promoting pro-inflammatory cytokines such as TNF-αand IL-12 that suppress tumor growth.
