Colon cancer(CC)laterality(right vs left)is recognized as a key determinant of clinical outcomes and treatment decisions in metastatic CC.Right-sided CC(RCC)often presents in older individuals and is associated with h...Colon cancer(CC)laterality(right vs left)is recognized as a key determinant of clinical outcomes and treatment decisions in metastatic CC.Right-sided CC(RCC)often presents in older individuals and is associated with higher rates of Kirsten rat sarcoma viral oncogene homolog and v-raf murine sarcoma viral oncogene homolog B1 mutations and deficient mismatch repair,leading to microsatellite instability-high status.Left-sided CC typically presents in younger individuals,demonstrates a more favorable prognosis,and is often Kirsten rat sarcoma viral oncogene homolog/neuroblastoma RAS viral oncogene homolog/v-raf murine sarcoma viral oncogene homolog B1 wild-type,making it more responsive to antiepidermal growth factor receptor therapy.RCC typically responds poorly to antiepidermal growth factor receptor agents;however,it may benefit from triplet chemotherapy(5-fluorouracil+leucovorin+oxaliplatin+irinotecan)with or without anti-angiogenic agents.Comprehensive molecular profiling remains challenging in low-resource settings due to limited access to advanced diagnostic tools.This review explores key epidemiological and molecular differences between RCC and left-sided CC.In the absence of complete genomic data,tumor sidedness can be a helpful guide for making treatment decisions.Here,we propose a practical algorithm that integrates basic immunohistochemistry to assess a tumor’s mismatch repair status and laterality,potentially facilitating therapy selection in resource-constrained environments.Recognizing laterality-specific trends in prognosis and treatment response can improve personalized care and outcomes for patients with CC in these environments,highlighting the essential role of cost-effective biomarker strategies.展开更多
Supported cell membrane coatings meet many requirements set to bioactive nanocarriers and materials,provided sidedness and fluidity of the natural membrane are maintained upon coating.However,the properties of a suppo...Supported cell membrane coatings meet many requirements set to bioactive nanocarriers and materials,provided sidedness and fluidity of the natural membrane are maintained upon coating.However,the properties of a support-surface responsible for maintaining correct sidedness and fluidity are unknown.Here,we briefly review the properties of natural membranes and membrane-isolation methods,with focus on the asymmetric distribution of functional groups in natural membranes(sidedness)and the ability of molecules to float across a membrane to form functional domains(fluidity).This review concludes that hydrophilic sugar-residues of glycoproteins in the outer-leaflet of cell membranes direct the more hydrophobic inner-leaflet towards a support-surface to create a correctly-sided membrane coating,regardless of electrostatic double-layer interactions.On positively-charged support-surfaces however,strong,electrostatic double-layer attraction of negatively-charged membranes can impede homogeneous coating.In correctly-sided membrane coatings,fluidity is maintained regardless of whether the surface carries a positive or negative charge.However,membranes are frozen on positively-charged,highly-curved,small nanoparticles and localized nanoscopic structures on a support-surface.This leaves an unsupported membrane coating in between nanostructures on planar support-surfaces that is in dual-sided contact with its aqueous environment,yielding enhanced fluidity in membrane coatings on nanostructured,planar support-surfaces as compared with smooth ones.展开更多
Background:Colorectal liver metastasis(CRLM)exhibits highly heterogeneity,with clinically and molecularly defined subgroups that differ in their prognosis.The aim of this study is to explore whether left-sided tumors ...Background:Colorectal liver metastasis(CRLM)exhibits highly heterogeneity,with clinically and molecularly defined subgroups that differ in their prognosis.The aim of this study is to explore whether left-sided tumors is clinically and gnomically distinct from right-sided tumors in CRLM.Methods:This retrospective study included 1,307 patients who underwent primary tumor and metastases resection at three academic centers in China from January 1,2012,to December 31,2020.Propensity score matching with 1:1 ratio matching was performed.The prognostic impact of tumor sidedness was determined after stratifying by the KRAS mutational status.Moreover,whole-exome sequencing(WES)of 200 liver tumor tissues were performed to describe the heterogeneity across the analysis of somatic and germline profiles.Results:The median follow-up was 68 months.Matching yielded 481 pairs of patients.Compared to right-sided CRLM,left-sided patients experienced with better 5-year overall survival(OS)in surgery responsiveness,with a 14.6 lower risk of death[hazard ratio(HR),1.36,95%confidence interval(CI),1.10-1.69,P=0.004].Interaction between tumor sidedness and KRAS status was statistically significant:left-sidedness was associated with better prognosis among KRAS wild-type patients(HR 1.71;95%CI:1.20-2.45;P=0.003),but not among KRAS mutated-type patients.Integrated molecular analyses showed that right-sided tumors more frequently harbored TP53,APC,KRAS,and BRAF alterations,and identified a critical role of KRAS mutation in correlation with their survival differences.Higher pathogenic germline variants were identified in the right-sided tumors compared with left-sided tumors(29.3%vs.15.5%,P=0.03).Conclusions:We demonstrated that the prognostic impacts of tumor sidedness in CRLM is restricted patients with KRAS wild-type tumors.Tumor sidedness displays considerable clinical and molecular heterogeneity that may associate with their therapy benefits and prognosis.展开更多
On February 21,China Institute of International Studies (CIIS) released the special research report"China-Russia Relations in the New Era."Assistant Minister of Foreign Affairs Liu Bin and Russian Ambassador...On February 21,China Institute of International Studies (CIIS) released the special research report"China-Russia Relations in the New Era."Assistant Minister of Foreign Affairs Liu Bin and Russian Ambassador to China Igor Morgulov attended the release conference and delivered speeches.CIIS President Chen Bo presided over the event and introduced the main content of the report.展开更多
1.Double-sided role of vibration and shaking Removing vibration and shaking is a pivotal engineering task,which is showcased,for instance,in spacecraft attitude control systems that ensure a precise three-dimensional ...1.Double-sided role of vibration and shaking Removing vibration and shaking is a pivotal engineering task,which is showcased,for instance,in spacecraft attitude control systems that ensure a precise three-dimensional orientation.Vibration or shaking,such as precession caused by external torque,nutation stemming from off-axis angular momentum,and wobbling due to geometric misalignment,necessitate active and passive damping mechanisms.This principle extends beyond spacecraft to centrifugation techniques,pivotal not only in washing machines but also in a spectrum of biomedical apparatuses used for isolating cells and organelles and separating DNA and proteins.展开更多
Copy number variations(CNVs)range in size from 50 base pairs(bp)to several megabases(Mb)and encompass various types of structural variations,such as insertions,deletions,duplications,and complex multiallelic events(Ma...Copy number variations(CNVs)range in size from 50 base pairs(bp)to several megabases(Mb)and encompass various types of structural variations,such as insertions,deletions,duplications,and complex multiallelic events(MacDonald et al.,2014).These genomic alterations modulate phenotype by altering gene dosage and transcriptional regulation,and are key drivers of biological evolution and determinants of genetic diversity and phenotypic variation.In recent years,CNVs have been detected in the genomes of various livestock species(Yuan et al.,2021;Chen et al.,2022).Upadhyay et al.(2017)conducted a comprehensive analysis of CNV distribution in the European cattle genome and determined that the Kit gene is associated with color-sidedness in English longhorn cattle.Another study presented extensive genome-wide information on CNVs in wild,commercial,and local chicken breeds to gain an integrated understanding of the domestication process and exclusively identified the genes involved(Chen et al.,2022).展开更多
Triangular fibrocartilage complex injuries are common in amateur and professional sports.These injuries are mainly caused by acute or chronic repetitive axial loads on the wrist,particularly on the ulnar side and in a...Triangular fibrocartilage complex injuries are common in amateur and professional sports.These injuries are mainly caused by acute or chronic repetitive axial loads on the wrist,particularly on the ulnar side and in association with rotations or radial/ulnar deviations.In order to treat professional athletes,a detailed specific knowledge of the pathology is needed.Moreover,the clinician should fully understand the specific and unique environment and needs of the athletes,their priorities and goals,the type of sport,the time of the season,and the position played.An early diagnosis and appropriate management with the quickest possible recovery time are the uppermost goals for both the athlete and the surgeon.A compromise between conservative vs surgical indications,athletes’needs and expectations,and financial implications should be achieved.Arthroscopic procedures should be timely planned when indicated as they could allow early diagnosis and treatment at the same time.Conservative measures are often used as first line treatment when possible.Peripheral lesions are treated by arthroscopic repair,whilst central lesions are treated by arthroscopic debridement.Further procedures(such as the Wafer procedure,ulnar osteotomies,etc.)have specific indications and great implications with regard to rehabilitation.展开更多
The founding ceremony and the first plenary meeting of SAC/SWG 38, Basic and general standards in agriculture, were held on October 29 in Beijing. Xu Changxing, First-class Inspector of the Standards Technical Managem...The founding ceremony and the first plenary meeting of SAC/SWG 38, Basic and general standards in agriculture, were held on October 29 in Beijing. Xu Changxing, First-class Inspector of the Standards Technical Management Department of SAMR, Xu Minggang, Academician of the Chinese Academy of Engineering and Chair of SAC/SWG 38, and 59 members of SAC/SWG 38 attended the meeting. Li Zhiping, Vice President of China National Institute of Standardization(CNIS), which holds the secretariat of the working group, presided over the meeting.展开更多
The founding ceremony and the first plenary meeting of SAC/TC 605,Rock and soil mechanics,was held on February 26 at the Northeastern University (NEU) in Liaoning province.The meeting was presided over by Feng Xiating...The founding ceremony and the first plenary meeting of SAC/TC 605,Rock and soil mechanics,was held on February 26 at the Northeastern University (NEU) in Liaoning province.The meeting was presided over by Feng Xiating, President of Northeastern University and Academician of Chinese Academy of Engineering (CAE), and addressed by Gao Tao.展开更多
On the afternoon of September7,the ChinaCambodia Dialogue on Cultural and Economic Exchanges,themed"building a China-Cambodia community with a shared future in the new era,"took place in Phnom Penh,capital o...On the afternoon of September7,the ChinaCambodia Dialogue on Cultural and Economic Exchanges,themed"building a China-Cambodia community with a shared future in the new era,"took place in Phnom Penh,capital of Cambodia.Du Zhanyuan,president of China International Communications Group (CICG),and Kha Leng,Secretary of State of the Ministry of Commerce of Cambodia,delivered speeches at the conference.Neth Pheaktra,Minister of Information of Cambodia,delivered an address via video.Chen Cong,Minister Counselor of the Embassy of China in Cambodia,and Chhean Leang,Secretary of State of the Ministry of Information of Cambodia,also attended.Chen Wenge,president of the CICG Center for Asia-Pacific,presided over the opening ceremony.展开更多
CCPIT BRICS Women’s Leadership Forum Was Held On June 11,the 2024 BRICS Women’s Leadership Forum was held in Beijing.Ren Hongbin,Chairman of the China Council for the Promotion of International Trade(CCPIT)and the C...CCPIT BRICS Women’s Leadership Forum Was Held On June 11,the 2024 BRICS Women’s Leadership Forum was held in Beijing.Ren Hongbin,Chairman of the China Council for the Promotion of International Trade(CCPIT)and the China Chamber of International Commerce(CCOIC),Huang Xiaowei,Vice-President and First Member of the Secretariat of the All-China Women’s Federation(ACWF),and Vice-Chairperson of the National Working Committee on Children and Women under the State Council,Siyabonga Cyprian Cwele,Ambassador of South Africa to China,Assem Hanafi,Ambassador of Egypt to China,Zhao Haiying,Chairperson of the Chinese Chapter of the BRICS Women’s Business Alliance(WBA),and Anna Nesterova,Rotating Chairperson of the BRICS WBA in 2024,attended the opening ceremony and delivered speeches.Yu Jianlong,Vice Chairman of the CCPIT and the CCOIC,presided over the opening ceremony.展开更多
To bolster mutual understanding,better understand major tasks of overseas standards organizations and facilitate in-depth cooperation in standardization field,China Standardization Press organized a high-end dialogue ...To bolster mutual understanding,better understand major tasks of overseas standards organizations and facilitate in-depth cooperation in standardization field,China Standardization Press organized a high-end dialogue on standards in March.Presided over by Ms.Yu Xinli,President of China Association for Standardization,Dr.Yuan Yu,Ms.Hu Yanan,Dr.Betty Xu and Mr.Xu Fang,as representatives of IEEE SA,ASTM International,SESEC and ANSI respectively,were invited to brief on the current development trend of standardization,the work plan and priorities of each organization in 2024,and their suggestions for China’s standardization work.展开更多
The Second China Standardization Conference was held in Quzhou city,Zhejiang province,on May 22-23,2024,which was hosted by China Association for Standardization(CAS).The conference was presided over by Zhang Xiuchun,...The Second China Standardization Conference was held in Quzhou city,Zhejiang province,on May 22-23,2024,which was hosted by China Association for Standardization(CAS).The conference was presided over by Zhang Xiuchun,Secretary General of CAS,and addressed by Xu Zhangyan,Mayor of Quzhou,and Li Yaowu,Deputy Secretary-General of Zhejiang Provincial People’s Government,and Yu Xinli,President of CAS.The conference was attended by more than 1,300 participants on site including renowned experts and scholars on standardization,leaders of research institutes,heads of standards technical management,and representatives of enterprises at home and abroad,and watched by over 20,000 audiences on line.展开更多
The session on robot standardization,hosted by CAS and organized by Robot Sub-committee of CAS,IAM Science and Technology Company,China Jiliang University and Jinyi Holding Group,was held on May 23,which was presided ...The session on robot standardization,hosted by CAS and organized by Robot Sub-committee of CAS,IAM Science and Technology Company,China Jiliang University and Jinyi Holding Group,was held on May 23,which was presided over by Ma Dejun,Vice President of CAS.The meeting invited 9 experts from well-known research institutes,universities and companies to deliver keynote speeches,sharing their latest research results and profound insights on robots and standards.Here,the main contents of two speeches are presented.展开更多
At the Techtextil show for technical textiles which take place in Frankfurt from April 23-25,Monforts launched its new coaTTex coating unit exclusively dedicated to air knife and knife-over-roller coating.For single-s...At the Techtextil show for technical textiles which take place in Frankfurt from April 23-25,Monforts launched its new coaTTex coating unit exclusively dedicated to air knife and knife-over-roller coating.For single-sided application with paste or foam,the versatile coaTTex is suitable for both incorporation into existing finishing ranges as well as installation with new Monforts lines,notably the industry-leading Montex stenter systems.展开更多
From November 30 to December 13,2023,the 28th Confer-ence of the Parties(COP28)was convened at Dubai Expo City in the United Arab Emirates(UAE)(Figure 1).Sultan Al Jaber,the CEO of the Abu Dhabi National Oil Company,p...From November 30 to December 13,2023,the 28th Confer-ence of the Parties(COP28)was convened at Dubai Expo City in the United Arab Emirates(UAE)(Figure 1).Sultan Al Jaber,the CEO of the Abu Dhabi National Oil Company,presided over the conference.The primary aims of the conference were to finalize the first global stocktake,facilitate ambitious climate targets,bolster climate financing for developing countries,and expedite investments in climate adaptation efforts.展开更多
A recent subgroup analysis of the TRIBE trial suggested that FOLFOXIRI plus bevacizumab may be a preferred option for the first-line treatment of only right-sided metastatic colorectal cancer(mCRC), regardless of RAS ...A recent subgroup analysis of the TRIBE trial suggested that FOLFOXIRI plus bevacizumab may be a preferred option for the first-line treatment of only right-sided metastatic colorectal cancer(mCRC), regardless of RAS or BRAF status. Our subanalysis of a phase Ⅱ trial of the FOLFOXIRI triplet regimen plus bevacizumab in patients with mCRC who had RAS mutant tumors showed that tumor shrinkage was better and the duration of treatment was longer in patients with leftsided tumors than in those with right-sided tumors, leading to a higher rate of conversion to surgery in mCRC patients with left-sided tumors. The early and deep responses to the triplet-regimen in patients with left-sided tumors might facilitate conversion treatment resulting in favorable survival. Our data suggest that the FOLFOXIRI plus bevacizumab might be a promising treatment for left-sided mCRC involving RAS mutant tumors.展开更多
文摘Colon cancer(CC)laterality(right vs left)is recognized as a key determinant of clinical outcomes and treatment decisions in metastatic CC.Right-sided CC(RCC)often presents in older individuals and is associated with higher rates of Kirsten rat sarcoma viral oncogene homolog and v-raf murine sarcoma viral oncogene homolog B1 mutations and deficient mismatch repair,leading to microsatellite instability-high status.Left-sided CC typically presents in younger individuals,demonstrates a more favorable prognosis,and is often Kirsten rat sarcoma viral oncogene homolog/neuroblastoma RAS viral oncogene homolog/v-raf murine sarcoma viral oncogene homolog B1 wild-type,making it more responsive to antiepidermal growth factor receptor therapy.RCC typically responds poorly to antiepidermal growth factor receptor agents;however,it may benefit from triplet chemotherapy(5-fluorouracil+leucovorin+oxaliplatin+irinotecan)with or without anti-angiogenic agents.Comprehensive molecular profiling remains challenging in low-resource settings due to limited access to advanced diagnostic tools.This review explores key epidemiological and molecular differences between RCC and left-sided CC.In the absence of complete genomic data,tumor sidedness can be a helpful guide for making treatment decisions.Here,we propose a practical algorithm that integrates basic immunohistochemistry to assess a tumor’s mismatch repair status and laterality,potentially facilitating therapy selection in resource-constrained environments.Recognizing laterality-specific trends in prognosis and treatment response can improve personalized care and outcomes for patients with CC in these environments,highlighting the essential role of cost-effective biomarker strategies.
基金financially supported by the National Key Research and Development Program of China(2017YFE0131700)the National Natural Science Foundation of China(52293383)the Soochow University,the Nankai University,and UMCG,Groningen,The Netherlands.
文摘Supported cell membrane coatings meet many requirements set to bioactive nanocarriers and materials,provided sidedness and fluidity of the natural membrane are maintained upon coating.However,the properties of a support-surface responsible for maintaining correct sidedness and fluidity are unknown.Here,we briefly review the properties of natural membranes and membrane-isolation methods,with focus on the asymmetric distribution of functional groups in natural membranes(sidedness)and the ability of molecules to float across a membrane to form functional domains(fluidity).This review concludes that hydrophilic sugar-residues of glycoproteins in the outer-leaflet of cell membranes direct the more hydrophobic inner-leaflet towards a support-surface to create a correctly-sided membrane coating,regardless of electrostatic double-layer interactions.On positively-charged support-surfaces however,strong,electrostatic double-layer attraction of negatively-charged membranes can impede homogeneous coating.In correctly-sided membrane coatings,fluidity is maintained regardless of whether the surface carries a positive or negative charge.However,membranes are frozen on positively-charged,highly-curved,small nanoparticles and localized nanoscopic structures on a support-surface.This leaves an unsupported membrane coating in between nanostructures on planar support-surfaces that is in dual-sided contact with its aqueous environment,yielding enhanced fluidity in membrane coatings on nanostructured,planar support-surfaces as compared with smooth ones.
基金supported by National Natural Science Foundation of China(81874182,M-0334)Natural Science Foundation of Shanghai(22ZR1413300)+2 种基金National Science and Technology Major Project(2017ZX10203204-007-004)Shanghai Municipal Health Bureau(201940043)Shanghai Hospital Development Center(SHDC12019X19).
文摘Background:Colorectal liver metastasis(CRLM)exhibits highly heterogeneity,with clinically and molecularly defined subgroups that differ in their prognosis.The aim of this study is to explore whether left-sided tumors is clinically and gnomically distinct from right-sided tumors in CRLM.Methods:This retrospective study included 1,307 patients who underwent primary tumor and metastases resection at three academic centers in China from January 1,2012,to December 31,2020.Propensity score matching with 1:1 ratio matching was performed.The prognostic impact of tumor sidedness was determined after stratifying by the KRAS mutational status.Moreover,whole-exome sequencing(WES)of 200 liver tumor tissues were performed to describe the heterogeneity across the analysis of somatic and germline profiles.Results:The median follow-up was 68 months.Matching yielded 481 pairs of patients.Compared to right-sided CRLM,left-sided patients experienced with better 5-year overall survival(OS)in surgery responsiveness,with a 14.6 lower risk of death[hazard ratio(HR),1.36,95%confidence interval(CI),1.10-1.69,P=0.004].Interaction between tumor sidedness and KRAS status was statistically significant:left-sidedness was associated with better prognosis among KRAS wild-type patients(HR 1.71;95%CI:1.20-2.45;P=0.003),but not among KRAS mutated-type patients.Integrated molecular analyses showed that right-sided tumors more frequently harbored TP53,APC,KRAS,and BRAF alterations,and identified a critical role of KRAS mutation in correlation with their survival differences.Higher pathogenic germline variants were identified in the right-sided tumors compared with left-sided tumors(29.3%vs.15.5%,P=0.03).Conclusions:We demonstrated that the prognostic impacts of tumor sidedness in CRLM is restricted patients with KRAS wild-type tumors.Tumor sidedness displays considerable clinical and molecular heterogeneity that may associate with their therapy benefits and prognosis.
文摘On February 21,China Institute of International Studies (CIIS) released the special research report"China-Russia Relations in the New Era."Assistant Minister of Foreign Affairs Liu Bin and Russian Ambassador to China Igor Morgulov attended the release conference and delivered speeches.CIIS President Chen Bo presided over the event and introduced the main content of the report.
文摘1.Double-sided role of vibration and shaking Removing vibration and shaking is a pivotal engineering task,which is showcased,for instance,in spacecraft attitude control systems that ensure a precise three-dimensional orientation.Vibration or shaking,such as precession caused by external torque,nutation stemming from off-axis angular momentum,and wobbling due to geometric misalignment,necessitate active and passive damping mechanisms.This principle extends beyond spacecraft to centrifugation techniques,pivotal not only in washing machines but also in a spectrum of biomedical apparatuses used for isolating cells and organelles and separating DNA and proteins.
基金the National Natural Science Foundation of China(No.32272851)the China Agriculture Research System of MOF and MARA(No.CARS-38)。
文摘Copy number variations(CNVs)range in size from 50 base pairs(bp)to several megabases(Mb)and encompass various types of structural variations,such as insertions,deletions,duplications,and complex multiallelic events(MacDonald et al.,2014).These genomic alterations modulate phenotype by altering gene dosage and transcriptional regulation,and are key drivers of biological evolution and determinants of genetic diversity and phenotypic variation.In recent years,CNVs have been detected in the genomes of various livestock species(Yuan et al.,2021;Chen et al.,2022).Upadhyay et al.(2017)conducted a comprehensive analysis of CNV distribution in the European cattle genome and determined that the Kit gene is associated with color-sidedness in English longhorn cattle.Another study presented extensive genome-wide information on CNVs in wild,commercial,and local chicken breeds to gain an integrated understanding of the domestication process and exclusively identified the genes involved(Chen et al.,2022).
文摘Triangular fibrocartilage complex injuries are common in amateur and professional sports.These injuries are mainly caused by acute or chronic repetitive axial loads on the wrist,particularly on the ulnar side and in association with rotations or radial/ulnar deviations.In order to treat professional athletes,a detailed specific knowledge of the pathology is needed.Moreover,the clinician should fully understand the specific and unique environment and needs of the athletes,their priorities and goals,the type of sport,the time of the season,and the position played.An early diagnosis and appropriate management with the quickest possible recovery time are the uppermost goals for both the athlete and the surgeon.A compromise between conservative vs surgical indications,athletes’needs and expectations,and financial implications should be achieved.Arthroscopic procedures should be timely planned when indicated as they could allow early diagnosis and treatment at the same time.Conservative measures are often used as first line treatment when possible.Peripheral lesions are treated by arthroscopic repair,whilst central lesions are treated by arthroscopic debridement.Further procedures(such as the Wafer procedure,ulnar osteotomies,etc.)have specific indications and great implications with regard to rehabilitation.
文摘The founding ceremony and the first plenary meeting of SAC/SWG 38, Basic and general standards in agriculture, were held on October 29 in Beijing. Xu Changxing, First-class Inspector of the Standards Technical Management Department of SAMR, Xu Minggang, Academician of the Chinese Academy of Engineering and Chair of SAC/SWG 38, and 59 members of SAC/SWG 38 attended the meeting. Li Zhiping, Vice President of China National Institute of Standardization(CNIS), which holds the secretariat of the working group, presided over the meeting.
文摘The founding ceremony and the first plenary meeting of SAC/TC 605,Rock and soil mechanics,was held on February 26 at the Northeastern University (NEU) in Liaoning province.The meeting was presided over by Feng Xiating, President of Northeastern University and Academician of Chinese Academy of Engineering (CAE), and addressed by Gao Tao.
文摘On the afternoon of September7,the ChinaCambodia Dialogue on Cultural and Economic Exchanges,themed"building a China-Cambodia community with a shared future in the new era,"took place in Phnom Penh,capital of Cambodia.Du Zhanyuan,president of China International Communications Group (CICG),and Kha Leng,Secretary of State of the Ministry of Commerce of Cambodia,delivered speeches at the conference.Neth Pheaktra,Minister of Information of Cambodia,delivered an address via video.Chen Cong,Minister Counselor of the Embassy of China in Cambodia,and Chhean Leang,Secretary of State of the Ministry of Information of Cambodia,also attended.Chen Wenge,president of the CICG Center for Asia-Pacific,presided over the opening ceremony.
文摘CCPIT BRICS Women’s Leadership Forum Was Held On June 11,the 2024 BRICS Women’s Leadership Forum was held in Beijing.Ren Hongbin,Chairman of the China Council for the Promotion of International Trade(CCPIT)and the China Chamber of International Commerce(CCOIC),Huang Xiaowei,Vice-President and First Member of the Secretariat of the All-China Women’s Federation(ACWF),and Vice-Chairperson of the National Working Committee on Children and Women under the State Council,Siyabonga Cyprian Cwele,Ambassador of South Africa to China,Assem Hanafi,Ambassador of Egypt to China,Zhao Haiying,Chairperson of the Chinese Chapter of the BRICS Women’s Business Alliance(WBA),and Anna Nesterova,Rotating Chairperson of the BRICS WBA in 2024,attended the opening ceremony and delivered speeches.Yu Jianlong,Vice Chairman of the CCPIT and the CCOIC,presided over the opening ceremony.
文摘To bolster mutual understanding,better understand major tasks of overseas standards organizations and facilitate in-depth cooperation in standardization field,China Standardization Press organized a high-end dialogue on standards in March.Presided over by Ms.Yu Xinli,President of China Association for Standardization,Dr.Yuan Yu,Ms.Hu Yanan,Dr.Betty Xu and Mr.Xu Fang,as representatives of IEEE SA,ASTM International,SESEC and ANSI respectively,were invited to brief on the current development trend of standardization,the work plan and priorities of each organization in 2024,and their suggestions for China’s standardization work.
文摘The Second China Standardization Conference was held in Quzhou city,Zhejiang province,on May 22-23,2024,which was hosted by China Association for Standardization(CAS).The conference was presided over by Zhang Xiuchun,Secretary General of CAS,and addressed by Xu Zhangyan,Mayor of Quzhou,and Li Yaowu,Deputy Secretary-General of Zhejiang Provincial People’s Government,and Yu Xinli,President of CAS.The conference was attended by more than 1,300 participants on site including renowned experts and scholars on standardization,leaders of research institutes,heads of standards technical management,and representatives of enterprises at home and abroad,and watched by over 20,000 audiences on line.
文摘The session on robot standardization,hosted by CAS and organized by Robot Sub-committee of CAS,IAM Science and Technology Company,China Jiliang University and Jinyi Holding Group,was held on May 23,which was presided over by Ma Dejun,Vice President of CAS.The meeting invited 9 experts from well-known research institutes,universities and companies to deliver keynote speeches,sharing their latest research results and profound insights on robots and standards.Here,the main contents of two speeches are presented.
文摘At the Techtextil show for technical textiles which take place in Frankfurt from April 23-25,Monforts launched its new coaTTex coating unit exclusively dedicated to air knife and knife-over-roller coating.For single-sided application with paste or foam,the versatile coaTTex is suitable for both incorporation into existing finishing ranges as well as installation with new Monforts lines,notably the industry-leading Montex stenter systems.
文摘From November 30 to December 13,2023,the 28th Confer-ence of the Parties(COP28)was convened at Dubai Expo City in the United Arab Emirates(UAE)(Figure 1).Sultan Al Jaber,the CEO of the Abu Dhabi National Oil Company,presided over the conference.The primary aims of the conference were to finalize the first global stocktake,facilitate ambitious climate targets,bolster climate financing for developing countries,and expedite investments in climate adaptation efforts.
文摘A recent subgroup analysis of the TRIBE trial suggested that FOLFOXIRI plus bevacizumab may be a preferred option for the first-line treatment of only right-sided metastatic colorectal cancer(mCRC), regardless of RAS or BRAF status. Our subanalysis of a phase Ⅱ trial of the FOLFOXIRI triplet regimen plus bevacizumab in patients with mCRC who had RAS mutant tumors showed that tumor shrinkage was better and the duration of treatment was longer in patients with leftsided tumors than in those with right-sided tumors, leading to a higher rate of conversion to surgery in mCRC patients with left-sided tumors. The early and deep responses to the triplet-regimen in patients with left-sided tumors might facilitate conversion treatment resulting in favorable survival. Our data suggest that the FOLFOXIRI plus bevacizumab might be a promising treatment for left-sided mCRC involving RAS mutant tumors.
