Colon cancer(CC)laterality(right vs left)is recognized as a key determinant of clinical outcomes and treatment decisions in metastatic CC.Right-sided CC(RCC)often presents in older individuals and is associated with h...Colon cancer(CC)laterality(right vs left)is recognized as a key determinant of clinical outcomes and treatment decisions in metastatic CC.Right-sided CC(RCC)often presents in older individuals and is associated with higher rates of Kirsten rat sarcoma viral oncogene homolog and v-raf murine sarcoma viral oncogene homolog B1 mutations and deficient mismatch repair,leading to microsatellite instability-high status.Left-sided CC typically presents in younger individuals,demonstrates a more favorable prognosis,and is often Kirsten rat sarcoma viral oncogene homolog/neuroblastoma RAS viral oncogene homolog/v-raf murine sarcoma viral oncogene homolog B1 wild-type,making it more responsive to antiepidermal growth factor receptor therapy.RCC typically responds poorly to antiepidermal growth factor receptor agents;however,it may benefit from triplet chemotherapy(5-fluorouracil+leucovorin+oxaliplatin+irinotecan)with or without anti-angiogenic agents.Comprehensive molecular profiling remains challenging in low-resource settings due to limited access to advanced diagnostic tools.This review explores key epidemiological and molecular differences between RCC and left-sided CC.In the absence of complete genomic data,tumor sidedness can be a helpful guide for making treatment decisions.Here,we propose a practical algorithm that integrates basic immunohistochemistry to assess a tumor’s mismatch repair status and laterality,potentially facilitating therapy selection in resource-constrained environments.Recognizing laterality-specific trends in prognosis and treatment response can improve personalized care and outcomes for patients with CC in these environments,highlighting the essential role of cost-effective biomarker strategies.展开更多
Cholecystectomy is a common procedure.Abnormalities in the anatomy of the biliary system are common but an abnormal location of the gallbladder is much rarer.Despite frequent pre-operative imaging,the aberrant locatio...Cholecystectomy is a common procedure.Abnormalities in the anatomy of the biliary system are common but an abnormal location of the gallbladder is much rarer.Despite frequent pre-operative imaging,the aberrant location of the gallbladder is commonly discovered at surgery.This article presents a case of a patient with the gallbladder located to the left of the falciform ligament in the absence of situs inversus totalis that presented with right upper quadrant pain.A laparoscopic cholecystectomy was performed and it was noted that the cystic duct originated from the right side.The presence of a left sided gall bladder is often associated with various biliary,portal venous and other anomalies that might lead to intra-operative injuries.The spectrum of unusual positions and anatomical gallbladder abnormalities is reviewed in order to facilitate elective and emergent cholecystectomy as well as other hepatobiliary procedures.With proper identification of the anatomy,minimally invasive approaches are still considered safe.展开更多
Tc, Jc and Rs properties of large area double sided YBCO thin films deposited on LaAlO3 substrates by direct current sputtering were reported.Film thickness of the obtained thin films is over 300 nm, Tc > 90 K; Rs ...Tc, Jc and Rs properties of large area double sided YBCO thin films deposited on LaAlO3 substrates by direct current sputtering were reported.Film thickness of the obtained thin films is over 300 nm, Tc > 90 K; Rs can be as low as less than 1.0 mΩ(77 K, 10 GHz).Homogenousity of the properties around the plane was studied.Under the measnous distributions.Influences of substrate temperature and Ar and O2 pressures on properties of the double-sided thin films were discussed.展开更多
0 IntroductionLet L = ab be a non-closed smooth arc oriented from a to b, t∈ L, t≠a,b, be the fixed point, andf(t) ∈H. (L) . The usual Hadamard principal value is defined asAbout properties and applications of sing...0 IntroductionLet L = ab be a non-closed smooth arc oriented from a to b, t∈ L, t≠a,b, be the fixed point, andf(t) ∈H. (L) . The usual Hadamard principal value is defined asAbout properties and applications of singular integals of high order were investigated by many authors([1],[2],[3] etc. ) In 1987, the concepts of Hadamard principal value at one-side for singular integralsof high order and the rules of their differentiation are introduced [4]. In this paper we established the rulesof substitution of variable for one-sided Hadamard principal value of singular integrals of high order, andthen, we gave some applications in evaluation of real definite integrals.展开更多
The dynamic thermal process during double-sided asymmetrical TIG backing welding of large thick plates （ 1 000 mm×700 mm×50 mm） is numerically simulated using MSC. MARC. The effect of arc distance on the t...The dynamic thermal process during double-sided asymmetrical TIG backing welding of large thick plates （ 1 000 mm×700 mm×50 mm） is numerically simulated using MSC. MARC. The effect of arc distance on the thermal cycle in weld zone during double-sided asymmetrical T1G backing welding is investigated. The results show that the workpiece experiences double-peak thermal cycle in double-sided asymmetrical TIG backing welding. On the one hand, the fore arc has the pre- heating effect on the rear pass, and the pre-heating temperature depends on the distance between the double arcs, the heat input of fore arc, and the initial temperature of workpiece. On the other hand, the rear arc has the post-heating effect on the fore pass. The mutual effects of two heat sources decrease with the increase of arc distance.展开更多
The presence of the appendix in an inguinal hernia sac has been referred to as Amyand’s hernia.Vermiform appendix located in an external hernia sac is not an uncommon condition,and the incidence of these cases is app...The presence of the appendix in an inguinal hernia sac has been referred to as Amyand’s hernia.Vermiform appendix located in an external hernia sac is not an uncommon condition,and the incidence of these cases is approximately 1%.In Amyand’s hernias,appendices are frequently found in the hernia sac;but an incarceration particularly on the left side is a very unusual sight.In this report we present 32-year-old male with Amyand’s hernia on the left side.展开更多
By designing the ordered structure on the key physical dimensions,metamaterial can obtain extraordinary physical properties.The method gives transparent conductive absorbing metamaterial with broadband and high absorp...By designing the ordered structure on the key physical dimensions,metamaterial can obtain extraordinary physical properties.The method gives transparent conductive absorbing metamaterial with broadband and high absorptivity.In this paper,a kind of absorbing metamaterial with indium tin oxide(ITO)glass substrate is designed.The design method of double-sided etched an open loop and linear metamaterial periodic structures is adopted.The thickness of the absorbing metamaterial is 2.5 mm.The research shows that the working bandwidth is between 8.9 GHz and 17.4 GHz,the absorption rate is 90%,and the transmittance of visible light is 85% on average.The absorbing metamaterial has wide application value to solve the problem of visualization and absorption characteristics.展开更多
A recent subgroup analysis of the TRIBE trial suggested that FOLFOXIRI plus bevacizumab may be a preferred option for the first-line treatment of only right-sided metastatic colorectal cancer(mCRC), regardless of RAS ...A recent subgroup analysis of the TRIBE trial suggested that FOLFOXIRI plus bevacizumab may be a preferred option for the first-line treatment of only right-sided metastatic colorectal cancer(mCRC), regardless of RAS or BRAF status. Our subanalysis of a phase Ⅱ trial of the FOLFOXIRI triplet regimen plus bevacizumab in patients with mCRC who had RAS mutant tumors showed that tumor shrinkage was better and the duration of treatment was longer in patients with leftsided tumors than in those with right-sided tumors, leading to a higher rate of conversion to surgery in mCRC patients with left-sided tumors. The early and deep responses to the triplet-regimen in patients with left-sided tumors might facilitate conversion treatment resulting in favorable survival. Our data suggest that the FOLFOXIRI plus bevacizumab might be a promising treatment for left-sided mCRC involving RAS mutant tumors.展开更多
To the Editor:Hepatobiliary anatomical variations may increase the complexity of surgery with a relevant risk of iatrogenic lesions.Left-sided gallbladder(LSG)is a rare and little known condition whereby the viscus is...To the Editor:Hepatobiliary anatomical variations may increase the complexity of surgery with a relevant risk of iatrogenic lesions.Left-sided gallbladder(LSG)is a rare and little known condition whereby the viscus is located on the visceral surface of the left lobe of the liver and is often discovered unexpectedly during surgery.The position of the gallbladder over the liver pedicle and the simultaneous presence of variations in the liver vascularization are potentially associated to a challenging surgical dissection and consequently to an increased risk of morbidity.Despite open approach remains an option in more complex procedures,cholecystectomy is usually performed with a minimally invasive technique,which is generally safe even in the rare case of an LSG,as long as a high level of awereness of anatomical variations and a careful surgical dissection are pursued.展开更多
The spacetime conservation element-solution element(CE/SE)method is extended to two-dimensional incompressible viscous flow in a two-sided lid-driven square cavity.Based on the SIMPLE method concept,the preconditioned...The spacetime conservation element-solution element(CE/SE)method is extended to two-dimensional incompressible viscous flow in a two-sided lid-driven square cavity.Based on the SIMPLE method concept,the preconditioned dual-time scheme is introduced for unsteady computations.The CE/SE-based code is validated by simulating one-sided lid-driven cavity flows.The two-sided lid-driven square cavity problem involves several interesting characteristics being successfully predicted,including development of a pair of off-corner vortices and a free shear layer in the case of parallel wall motion,as well as the appearance of corner vortices for lower Reynolds numbers in the case of anti-parallel motion of the walls.It is found that both the Reynolds number and the direction of the moving walls affect the fluid flow in the cavity.展开更多
Biomolecular separation is an important technique for biological applications such as medical diagnosis where molecular selectivity and ux control are key technical concerns^([1]).Nanoporous membranes have been consid...Biomolecular separation is an important technique for biological applications such as medical diagnosis where molecular selectivity and ux control are key technical concerns^([1]).Nanoporous membranes have been considered as a powerful platform to ltrate and separate biomolecules^([2]).Among diverse membranes,the ion-track-etched membranes with uniform yet tunable pore size,density and shapes have been widely recognized due to their excellent selectivity and high permlability.展开更多
Randomness is an essential resource and plays important roles in various applications ranging from cryptography to simulation of complex systems.Certified randomness from quantum process is ensured to have the element...Randomness is an essential resource and plays important roles in various applications ranging from cryptography to simulation of complex systems.Certified randomness from quantum process is ensured to have the element of privacy but usually relies on the device's behavior.To certify randomness without the characterization for device,it is crucial to realize the one-sided device-independent random number generation based on quantum steering,which guarantees security of randomness and relaxes the demands of one party's device.Here,we distribute quantum steering between two distant users through a 2 km fiber channel and generate quantum random numbers at the remote station with untrustworthy device.We certify the steering-based randomness by reconstructing covariance matrix of the Gaussian entangled state shared between distant parties.Then,the quantum random numbers with a generation rate of 7.06 Mbits/s are extracted from the measured amplitude quadrature fluctuation of the state owned by the remote party.Our results demonstrate the first realization of steering-based random numbers extraction in a practical fiber channel,which paves the way to the quantum random numbers generation in asymmetric networks.展开更多
Self-chaotic dual-mode and tri-mode microcavity lasers have been recently proposed and demonstrated for highspeed random number generation.Here,we report the characteristics of irregular pulse packages and self-chaos ...Self-chaotic dual-mode and tri-mode microcavity lasers have been recently proposed and demonstrated for highspeed random number generation.Here,we report the characteristics of irregular pulse packages and self-chaos operation for a dual-mode circular-sided square microcavity laser.In addition to the mode interaction between the fundamental and first-order transverse modes,we observed irregular pulse packages due to the mode beating of near-degenerate modes for the first time to our best knowledge.Moreover,a successive route from periodic-one and periodic-three states to chaos is first experimentally illustrated by increasing injection current.The chaotic state is observed over a current range of 10 mA,and the maximum chaos effective bandwidth of 22.4 GHz is realized with a flatness of±4 d B.Chaotic characteristics are also investigated for different longitudinal modes,which indicates that the self-chaotic microlaser can provide robust parallel chaotic outputs for practical application.展开更多
Double-sided microlens arrays(DSMLAs)include combinations of two single-sided MLAs to overcome positioning errors and greatly improve light transmissivity compared to other types of lenses.Precision glass molding(PGM)...Double-sided microlens arrays(DSMLAs)include combinations of two single-sided MLAs to overcome positioning errors and greatly improve light transmissivity compared to other types of lenses.Precision glass molding(PGM)is used to fabricate DSMLAs,but controlling alignment errors during this process is challenging.In this paper,a mold assembly was manufactured with a novel combination of materials to improve the alignment accuracy of mold cores during PGM by using the nonlinear thermal expansion characteristics of the various materials to improve the DSMLA alignment accuracy.By establishing a mathematical model of the DSMLA alignment error and a thermal expansion model of the mold-sleeve pair,the relationship between the maximum alignment error of the DSMLA and the mold-sleeve gap was determined.This research provides a method to optimize the mold-sleeve gap and minimize the alignment error of the DSMLA.The measured DSMLA alignment error was 10.56μm,which is similar to the predicted maximum alignment error.Optical measurements showed that the uniformity of the homogenized beam spot was 97.81%,and the effective homogeneous area accounted for 91.66%of the total area.This proposed method provides a novel strategy to improve the performance of DSMLAs.展开更多
Consider the two-sided truncation distrbution families written in the formf（x,θ）dx=w（θ<sub>1</sub>, θ<sub>2</sub>）h（x）I<sub>[θ<sub>1</sub>,θ<sub>2</sub>...Consider the two-sided truncation distrbution families written in the formf（x,θ）dx=w（θ<sub>1</sub>, θ<sub>2</sub>）h（x）I<sub>[θ<sub>1</sub>,θ<sub>2</sub>]</sub>（x）dx, where θ=（θ<sub>1</sub>,θ<sub>2</sub>）.T（x）=（t<sub>1</sub>（x）, t<sub>2</sub>（x））=（min（x<sub>1</sub>,…,x<sub>m</sub>）, max（x<sub>1</sub>, …,x<sub>m</sub>））is a sufficient statistic and its marginal density is denoted by f（t）dμ<sup>T</sup>. The prior distribution of θ belongs to the familyF={G:∫‖θ‖<sup>2</sup>dG（θ）【∞}.In this paper, the author constructs the empirical Bayes estimator （EBE） of θ, φ<sub>n</sub> （t）, by using the kernel estimation of f（t）. Under a quite general assumption imposed upon f（t） and h（x）, it is shown that φ<sub>n</sub>（t） is an asymptotically optimal EBE of θ.展开更多
Supported cell membrane coatings meet many requirements set to bioactive nanocarriers and materials,provided sidedness and fluidity of the natural membrane are maintained upon coating.However,the properties of a suppo...Supported cell membrane coatings meet many requirements set to bioactive nanocarriers and materials,provided sidedness and fluidity of the natural membrane are maintained upon coating.However,the properties of a support-surface responsible for maintaining correct sidedness and fluidity are unknown.Here,we briefly review the properties of natural membranes and membrane-isolation methods,with focus on the asymmetric distribution of functional groups in natural membranes(sidedness)and the ability of molecules to float across a membrane to form functional domains(fluidity).This review concludes that hydrophilic sugar-residues of glycoproteins in the outer-leaflet of cell membranes direct the more hydrophobic inner-leaflet towards a support-surface to create a correctly-sided membrane coating,regardless of electrostatic double-layer interactions.On positively-charged support-surfaces however,strong,electrostatic double-layer attraction of negatively-charged membranes can impede homogeneous coating.In correctly-sided membrane coatings,fluidity is maintained regardless of whether the surface carries a positive or negative charge.However,membranes are frozen on positively-charged,highly-curved,small nanoparticles and localized nanoscopic structures on a support-surface.This leaves an unsupported membrane coating in between nanostructures on planar support-surfaces that is in dual-sided contact with its aqueous environment,yielding enhanced fluidity in membrane coatings on nanostructured,planar support-surfaces as compared with smooth ones.展开更多
Left sided valvular heart disease poses major impact on life and lifestyle.Medical therapy merely palliates chronic severe valve disease and once symptoms or haemodynamic sequelae appear,life expectancy is markedly tr...Left sided valvular heart disease poses major impact on life and lifestyle.Medical therapy merely palliates chronic severe valve disease and once symptoms or haemodynamic sequelae appear,life expectancy is markedly truncated.In this article,we review the mechanisms of valve pathology,latest evidence in the quest for pharmacological options,means by which to predict deterioration,and standard and novel treatment options.展开更多
Background:Colorectal liver metastasis(CRLM)exhibits highly heterogeneity,with clinically and molecularly defined subgroups that differ in their prognosis.The aim of this study is to explore whether left-sided tumors ...Background:Colorectal liver metastasis(CRLM)exhibits highly heterogeneity,with clinically and molecularly defined subgroups that differ in their prognosis.The aim of this study is to explore whether left-sided tumors is clinically and gnomically distinct from right-sided tumors in CRLM.Methods:This retrospective study included 1,307 patients who underwent primary tumor and metastases resection at three academic centers in China from January 1,2012,to December 31,2020.Propensity score matching with 1:1 ratio matching was performed.The prognostic impact of tumor sidedness was determined after stratifying by the KRAS mutational status.Moreover,whole-exome sequencing(WES)of 200 liver tumor tissues were performed to describe the heterogeneity across the analysis of somatic and germline profiles.Results:The median follow-up was 68 months.Matching yielded 481 pairs of patients.Compared to right-sided CRLM,left-sided patients experienced with better 5-year overall survival(OS)in surgery responsiveness,with a 14.6 lower risk of death[hazard ratio(HR),1.36,95%confidence interval(CI),1.10-1.69,P=0.004].Interaction between tumor sidedness and KRAS status was statistically significant:left-sidedness was associated with better prognosis among KRAS wild-type patients(HR 1.71;95%CI:1.20-2.45;P=0.003),but not among KRAS mutated-type patients.Integrated molecular analyses showed that right-sided tumors more frequently harbored TP53,APC,KRAS,and BRAF alterations,and identified a critical role of KRAS mutation in correlation with their survival differences.Higher pathogenic germline variants were identified in the right-sided tumors compared with left-sided tumors(29.3%vs.15.5%,P=0.03).Conclusions:We demonstrated that the prognostic impacts of tumor sidedness in CRLM is restricted patients with KRAS wild-type tumors.Tumor sidedness displays considerable clinical and molecular heterogeneity that may associate with their therapy benefits and prognosis.展开更多
The structure theorem of the primitive rings with non-zero socles has been proved in Refs. [1] and (2)In the former, the finite topological method is used; and in the latter the method of right and left double modules...The structure theorem of the primitive rings with non-zero socles has been proved in Refs. [1] and (2)In the former, the finite topological method is used; and in the latter the method of right and left double modules. It should be noted that there is a close relation between the structure of the primitive rings of this展开更多
In Mathematische Annalen, （171 （1967）, 79—80）,K. Koh showed that, if a ring R contains n（n>1） left （right） zero divisors, then |R|≤n2. In Journal of Beijing Normal University, （1983, 3:1—5）, Wu Pinsan ...In Mathematische Annalen, （171 （1967）, 79—80）,K. Koh showed that, if a ring R contains n（n>1） left （right） zero divisors, then |R|≤n2. In Journal of Beijing Normal University, （1983, 3:1—5）, Wu Pinsan studied the non-commutative rings R which contain n（n>1） left （right） zero divisors and |R|=n2. Let D（S0） denote the set of all two-展开更多
文摘Colon cancer(CC)laterality(right vs left)is recognized as a key determinant of clinical outcomes and treatment decisions in metastatic CC.Right-sided CC(RCC)often presents in older individuals and is associated with higher rates of Kirsten rat sarcoma viral oncogene homolog and v-raf murine sarcoma viral oncogene homolog B1 mutations and deficient mismatch repair,leading to microsatellite instability-high status.Left-sided CC typically presents in younger individuals,demonstrates a more favorable prognosis,and is often Kirsten rat sarcoma viral oncogene homolog/neuroblastoma RAS viral oncogene homolog/v-raf murine sarcoma viral oncogene homolog B1 wild-type,making it more responsive to antiepidermal growth factor receptor therapy.RCC typically responds poorly to antiepidermal growth factor receptor agents;however,it may benefit from triplet chemotherapy(5-fluorouracil+leucovorin+oxaliplatin+irinotecan)with or without anti-angiogenic agents.Comprehensive molecular profiling remains challenging in low-resource settings due to limited access to advanced diagnostic tools.This review explores key epidemiological and molecular differences between RCC and left-sided CC.In the absence of complete genomic data,tumor sidedness can be a helpful guide for making treatment decisions.Here,we propose a practical algorithm that integrates basic immunohistochemistry to assess a tumor’s mismatch repair status and laterality,potentially facilitating therapy selection in resource-constrained environments.Recognizing laterality-specific trends in prognosis and treatment response can improve personalized care and outcomes for patients with CC in these environments,highlighting the essential role of cost-effective biomarker strategies.
文摘Cholecystectomy is a common procedure.Abnormalities in the anatomy of the biliary system are common but an abnormal location of the gallbladder is much rarer.Despite frequent pre-operative imaging,the aberrant location of the gallbladder is commonly discovered at surgery.This article presents a case of a patient with the gallbladder located to the left of the falciform ligament in the absence of situs inversus totalis that presented with right upper quadrant pain.A laparoscopic cholecystectomy was performed and it was noted that the cystic duct originated from the right side.The presence of a left sided gall bladder is often associated with various biliary,portal venous and other anomalies that might lead to intra-operative injuries.The spectrum of unusual positions and anatomical gallbladder abnormalities is reviewed in order to facilitate elective and emergent cholecystectomy as well as other hepatobiliary procedures.With proper identification of the anatomy,minimally invasive approaches are still considered safe.
文摘Tc, Jc and Rs properties of large area double sided YBCO thin films deposited on LaAlO3 substrates by direct current sputtering were reported.Film thickness of the obtained thin films is over 300 nm, Tc > 90 K; Rs can be as low as less than 1.0 mΩ(77 K, 10 GHz).Homogenousity of the properties around the plane was studied.Under the measnous distributions.Influences of substrate temperature and Ar and O2 pressures on properties of the double-sided thin films were discussed.
文摘0 IntroductionLet L = ab be a non-closed smooth arc oriented from a to b, t∈ L, t≠a,b, be the fixed point, andf(t) ∈H. (L) . The usual Hadamard principal value is defined asAbout properties and applications of singular integals of high order were investigated by many authors([1],[2],[3] etc. ) In 1987, the concepts of Hadamard principal value at one-side for singular integralsof high order and the rules of their differentiation are introduced [4]. In this paper we established the rulesof substitution of variable for one-sided Hadamard principal value of singular integrals of high order, andthen, we gave some applications in evaluation of real definite integrals.
文摘The dynamic thermal process during double-sided asymmetrical TIG backing welding of large thick plates （ 1 000 mm×700 mm×50 mm） is numerically simulated using MSC. MARC. The effect of arc distance on the thermal cycle in weld zone during double-sided asymmetrical T1G backing welding is investigated. The results show that the workpiece experiences double-peak thermal cycle in double-sided asymmetrical TIG backing welding. On the one hand, the fore arc has the pre- heating effect on the rear pass, and the pre-heating temperature depends on the distance between the double arcs, the heat input of fore arc, and the initial temperature of workpiece. On the other hand, the rear arc has the post-heating effect on the fore pass. The mutual effects of two heat sources decrease with the increase of arc distance.
文摘The presence of the appendix in an inguinal hernia sac has been referred to as Amyand’s hernia.Vermiform appendix located in an external hernia sac is not an uncommon condition,and the incidence of these cases is approximately 1%.In Amyand’s hernias,appendices are frequently found in the hernia sac;but an incarceration particularly on the left side is a very unusual sight.In this report we present 32-year-old male with Amyand’s hernia on the left side.
基金supported by the Shanxi Province Youth Science and Technology Research Foundation(No.201901D211577)the Shanxi Province Natural Science Foundation(No.201901D111001)。
文摘By designing the ordered structure on the key physical dimensions,metamaterial can obtain extraordinary physical properties.The method gives transparent conductive absorbing metamaterial with broadband and high absorptivity.In this paper,a kind of absorbing metamaterial with indium tin oxide(ITO)glass substrate is designed.The design method of double-sided etched an open loop and linear metamaterial periodic structures is adopted.The thickness of the absorbing metamaterial is 2.5 mm.The research shows that the working bandwidth is between 8.9 GHz and 17.4 GHz,the absorption rate is 90%,and the transmittance of visible light is 85% on average.The absorbing metamaterial has wide application value to solve the problem of visualization and absorption characteristics.
文摘A recent subgroup analysis of the TRIBE trial suggested that FOLFOXIRI plus bevacizumab may be a preferred option for the first-line treatment of only right-sided metastatic colorectal cancer(mCRC), regardless of RAS or BRAF status. Our subanalysis of a phase Ⅱ trial of the FOLFOXIRI triplet regimen plus bevacizumab in patients with mCRC who had RAS mutant tumors showed that tumor shrinkage was better and the duration of treatment was longer in patients with leftsided tumors than in those with right-sided tumors, leading to a higher rate of conversion to surgery in mCRC patients with left-sided tumors. The early and deep responses to the triplet-regimen in patients with left-sided tumors might facilitate conversion treatment resulting in favorable survival. Our data suggest that the FOLFOXIRI plus bevacizumab might be a promising treatment for left-sided mCRC involving RAS mutant tumors.
文摘To the Editor:Hepatobiliary anatomical variations may increase the complexity of surgery with a relevant risk of iatrogenic lesions.Left-sided gallbladder(LSG)is a rare and little known condition whereby the viscus is located on the visceral surface of the left lobe of the liver and is often discovered unexpectedly during surgery.The position of the gallbladder over the liver pedicle and the simultaneous presence of variations in the liver vascularization are potentially associated to a challenging surgical dissection and consequently to an increased risk of morbidity.Despite open approach remains an option in more complex procedures,cholecystectomy is usually performed with a minimally invasive technique,which is generally safe even in the rare case of an LSG,as long as a high level of awereness of anatomical variations and a careful surgical dissection are pursued.
基金Supported by the Institute of Crustal Dynamics,CEA under Grant No ZDJ2010-26Wenchuan Fault Scientific Drilling(WFSD-10).
文摘The spacetime conservation element-solution element(CE/SE)method is extended to two-dimensional incompressible viscous flow in a two-sided lid-driven square cavity.Based on the SIMPLE method concept,the preconditioned dual-time scheme is introduced for unsteady computations.The CE/SE-based code is validated by simulating one-sided lid-driven cavity flows.The two-sided lid-driven square cavity problem involves several interesting characteristics being successfully predicted,including development of a pair of off-corner vortices and a free shear layer in the case of parallel wall motion,as well as the appearance of corner vortices for lower Reynolds numbers in the case of anti-parallel motion of the walls.It is found that both the Reynolds number and the direction of the moving walls affect the fluid flow in the cavity.
文摘Biomolecular separation is an important technique for biological applications such as medical diagnosis where molecular selectivity and ux control are key technical concerns^([1]).Nanoporous membranes have been considered as a powerful platform to ltrate and separate biomolecules^([2]).Among diverse membranes,the ion-track-etched membranes with uniform yet tunable pore size,density and shapes have been widely recognized due to their excellent selectivity and high permlability.
基金supported by the National Natural Science Foundation of China(Grants No.12434015,No.12125402,No.12350006,and No.123B2073)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0301500)+2 种基金the Beijing Natural Science Foundation(Grant No.Z240007)the Fundamental Research Program of Shanxi Province(Grant No.20210302121002)the Fund for Shanxi“1331 Project”Key Subjects Construction.
文摘Randomness is an essential resource and plays important roles in various applications ranging from cryptography to simulation of complex systems.Certified randomness from quantum process is ensured to have the element of privacy but usually relies on the device's behavior.To certify randomness without the characterization for device,it is crucial to realize the one-sided device-independent random number generation based on quantum steering,which guarantees security of randomness and relaxes the demands of one party's device.Here,we distribute quantum steering between two distant users through a 2 km fiber channel and generate quantum random numbers at the remote station with untrustworthy device.We certify the steering-based randomness by reconstructing covariance matrix of the Gaussian entangled state shared between distant parties.Then,the quantum random numbers with a generation rate of 7.06 Mbits/s are extracted from the measured amplitude quadrature fluctuation of the state owned by the remote party.Our results demonstrate the first realization of steering-based random numbers extraction in a practical fiber channel,which paves the way to the quantum random numbers generation in asymmetric networks.
基金National Natural Science Foundation of China(12274407,61874113,61935018,62122073)。
文摘Self-chaotic dual-mode and tri-mode microcavity lasers have been recently proposed and demonstrated for highspeed random number generation.Here,we report the characteristics of irregular pulse packages and self-chaos operation for a dual-mode circular-sided square microcavity laser.In addition to the mode interaction between the fundamental and first-order transverse modes,we observed irregular pulse packages due to the mode beating of near-degenerate modes for the first time to our best knowledge.Moreover,a successive route from periodic-one and periodic-three states to chaos is first experimentally illustrated by increasing injection current.The chaotic state is observed over a current range of 10 mA,and the maximum chaos effective bandwidth of 22.4 GHz is realized with a flatness of±4 d B.Chaotic characteristics are also investigated for different longitudinal modes,which indicates that the self-chaotic microlaser can provide robust parallel chaotic outputs for practical application.
基金support of the National Natural Science Foundation of China(52205440)the Beijing Municipal Natural Science Foundation(JQ20014)the Science and Technology Major Project of Jiangxi Province(20212AAE01002).
文摘Double-sided microlens arrays(DSMLAs)include combinations of two single-sided MLAs to overcome positioning errors and greatly improve light transmissivity compared to other types of lenses.Precision glass molding(PGM)is used to fabricate DSMLAs,but controlling alignment errors during this process is challenging.In this paper,a mold assembly was manufactured with a novel combination of materials to improve the alignment accuracy of mold cores during PGM by using the nonlinear thermal expansion characteristics of the various materials to improve the DSMLA alignment accuracy.By establishing a mathematical model of the DSMLA alignment error and a thermal expansion model of the mold-sleeve pair,the relationship between the maximum alignment error of the DSMLA and the mold-sleeve gap was determined.This research provides a method to optimize the mold-sleeve gap and minimize the alignment error of the DSMLA.The measured DSMLA alignment error was 10.56μm,which is similar to the predicted maximum alignment error.Optical measurements showed that the uniformity of the homogenized beam spot was 97.81%,and the effective homogeneous area accounted for 91.66%of the total area.This proposed method provides a novel strategy to improve the performance of DSMLAs.
基金Projects supported by the Science Fund of the Chinese Academy of Sciences.
文摘Consider the two-sided truncation distrbution families written in the formf（x,θ）dx=w（θ<sub>1</sub>, θ<sub>2</sub>）h（x）I<sub>[θ<sub>1</sub>,θ<sub>2</sub>]</sub>（x）dx, where θ=（θ<sub>1</sub>,θ<sub>2</sub>）.T（x）=（t<sub>1</sub>（x）, t<sub>2</sub>（x））=（min（x<sub>1</sub>,…,x<sub>m</sub>）, max（x<sub>1</sub>, …,x<sub>m</sub>））is a sufficient statistic and its marginal density is denoted by f（t）dμ<sup>T</sup>. The prior distribution of θ belongs to the familyF={G:∫‖θ‖<sup>2</sup>dG（θ）【∞}.In this paper, the author constructs the empirical Bayes estimator （EBE） of θ, φ<sub>n</sub> （t）, by using the kernel estimation of f（t）. Under a quite general assumption imposed upon f（t） and h（x）, it is shown that φ<sub>n</sub>（t） is an asymptotically optimal EBE of θ.
基金financially supported by the National Key Research and Development Program of China(2017YFE0131700)the National Natural Science Foundation of China(52293383)the Soochow University,the Nankai University,and UMCG,Groningen,The Netherlands.
文摘Supported cell membrane coatings meet many requirements set to bioactive nanocarriers and materials,provided sidedness and fluidity of the natural membrane are maintained upon coating.However,the properties of a support-surface responsible for maintaining correct sidedness and fluidity are unknown.Here,we briefly review the properties of natural membranes and membrane-isolation methods,with focus on the asymmetric distribution of functional groups in natural membranes(sidedness)and the ability of molecules to float across a membrane to form functional domains(fluidity).This review concludes that hydrophilic sugar-residues of glycoproteins in the outer-leaflet of cell membranes direct the more hydrophobic inner-leaflet towards a support-surface to create a correctly-sided membrane coating,regardless of electrostatic double-layer interactions.On positively-charged support-surfaces however,strong,electrostatic double-layer attraction of negatively-charged membranes can impede homogeneous coating.In correctly-sided membrane coatings,fluidity is maintained regardless of whether the surface carries a positive or negative charge.However,membranes are frozen on positively-charged,highly-curved,small nanoparticles and localized nanoscopic structures on a support-surface.This leaves an unsupported membrane coating in between nanostructures on planar support-surfaces that is in dual-sided contact with its aqueous environment,yielding enhanced fluidity in membrane coatings on nanostructured,planar support-surfaces as compared with smooth ones.
文摘Left sided valvular heart disease poses major impact on life and lifestyle.Medical therapy merely palliates chronic severe valve disease and once symptoms or haemodynamic sequelae appear,life expectancy is markedly truncated.In this article,we review the mechanisms of valve pathology,latest evidence in the quest for pharmacological options,means by which to predict deterioration,and standard and novel treatment options.
基金supported by National Natural Science Foundation of China(81874182,M-0334)Natural Science Foundation of Shanghai(22ZR1413300)+2 种基金National Science and Technology Major Project(2017ZX10203204-007-004)Shanghai Municipal Health Bureau(201940043)Shanghai Hospital Development Center(SHDC12019X19).
文摘Background:Colorectal liver metastasis(CRLM)exhibits highly heterogeneity,with clinically and molecularly defined subgroups that differ in their prognosis.The aim of this study is to explore whether left-sided tumors is clinically and gnomically distinct from right-sided tumors in CRLM.Methods:This retrospective study included 1,307 patients who underwent primary tumor and metastases resection at three academic centers in China from January 1,2012,to December 31,2020.Propensity score matching with 1:1 ratio matching was performed.The prognostic impact of tumor sidedness was determined after stratifying by the KRAS mutational status.Moreover,whole-exome sequencing(WES)of 200 liver tumor tissues were performed to describe the heterogeneity across the analysis of somatic and germline profiles.Results:The median follow-up was 68 months.Matching yielded 481 pairs of patients.Compared to right-sided CRLM,left-sided patients experienced with better 5-year overall survival(OS)in surgery responsiveness,with a 14.6 lower risk of death[hazard ratio(HR),1.36,95%confidence interval(CI),1.10-1.69,P=0.004].Interaction between tumor sidedness and KRAS status was statistically significant:left-sidedness was associated with better prognosis among KRAS wild-type patients(HR 1.71;95%CI:1.20-2.45;P=0.003),but not among KRAS mutated-type patients.Integrated molecular analyses showed that right-sided tumors more frequently harbored TP53,APC,KRAS,and BRAF alterations,and identified a critical role of KRAS mutation in correlation with their survival differences.Higher pathogenic germline variants were identified in the right-sided tumors compared with left-sided tumors(29.3%vs.15.5%,P=0.03).Conclusions:We demonstrated that the prognostic impacts of tumor sidedness in CRLM is restricted patients with KRAS wild-type tumors.Tumor sidedness displays considerable clinical and molecular heterogeneity that may associate with their therapy benefits and prognosis.
文摘The structure theorem of the primitive rings with non-zero socles has been proved in Refs. [1] and (2)In the former, the finite topological method is used; and in the latter the method of right and left double modules. It should be noted that there is a close relation between the structure of the primitive rings of this
文摘In Mathematische Annalen, （171 （1967）, 79—80）,K. Koh showed that, if a ring R contains n（n>1） left （right） zero divisors, then |R|≤n2. In Journal of Beijing Normal University, （1983, 3:1—5）, Wu Pinsan studied the non-commutative rings R which contain n（n>1） left （right） zero divisors and |R|=n2. Let D（S0） denote the set of all two-
