Objective:To investigate the effects of ethanolic extract of Lagenaria siceraria fruit(ELSF) on fat amassment and serum TNF-αin high-fat diet-induced obese rats.Methods:The high fat diet induced obese rals were orall...Objective:To investigate the effects of ethanolic extract of Lagenaria siceraria fruit(ELSF) on fat amassment and serum TNF-αin high-fat diet-induced obese rats.Methods:The high fat diet induced obese rals were orally treated with orlistat(50 mg/kg) and ELSF(100,200.300 mg/kg/day) to the respective treatment groups.The body weight,lasting blood glucose level,lipid profile, serum levels of tumor necrosis factor-α(TNF-α) in rats were measured after 30 days of treatment adn compared to the obese control animals.Results:ELSF significantly(P 【 0.001) reduced the body weight gain,fasting blood glucose,total cholesterol,triglyceride,total protein and TNF-α.Conclusions:These encouraging findings suggest that Lagenaria siceraria has excellent pharmacological potential to prevent fat amassment.展开更多
文摘Objective:To investigate the effects of ethanolic extract of Lagenaria siceraria fruit(ELSF) on fat amassment and serum TNF-αin high-fat diet-induced obese rats.Methods:The high fat diet induced obese rals were orally treated with orlistat(50 mg/kg) and ELSF(100,200.300 mg/kg/day) to the respective treatment groups.The body weight,lasting blood glucose level,lipid profile, serum levels of tumor necrosis factor-α(TNF-α) in rats were measured after 30 days of treatment adn compared to the obese control animals.Results:ELSF significantly(P 【 0.001) reduced the body weight gain,fasting blood glucose,total cholesterol,triglyceride,total protein and TNF-α.Conclusions:These encouraging findings suggest that Lagenaria siceraria has excellent pharmacological potential to prevent fat amassment.
