Autologous submandibular gland（SMG） transplantation has been proved to ameliorate the discomforts in patients with severe keratoconjunctivitis sicca. The transplanted glands underwent a hypofunctional period and the...Autologous submandibular gland（SMG） transplantation has been proved to ameliorate the discomforts in patients with severe keratoconjunctivitis sicca. The transplanted glands underwent a hypofunctional period and then restored secretion spontaneously.This study aims to investigate whether autonomic nerves reinnervate the grafts and contribute to the functional recovery, and further determine the origin of these nerves. Parts of the transplanted SMGs were collected from the epiphora patients, and a rabbit SMG transplantation model was established to fulfill the serial observation on the transplanted glands with time. The results showed that autonomic nerves distributed in the transplanted SMGs and parasympathetic ganglionic cells were observed in the stroma of the glands. Low-dense and unevenly distributed cholinergic axons, severe acinar atrophy and fibrosis were visible in the patients＇ glands 4–6 months post-transplantation, whereas the cholinergic axon density and acinar area were increased with time. The acinar area or the secretory flow rate of the transplanted glands was statistically correlated with the cholinergic axon density in the rabbit model, respectively. Meanwhile, large cholinergic nerve trunks were found to locate in the temporal fascia lower to the gland, and sympathetic plexus concomitant with the arteries was observed both in the adjacent fascia and in the stroma of the glands. In summary, the transplanted SMGs are reinnervated by autonomic nerves and the cholinergic nerves play a role in the morphological and functional restoration of the glands. Moreover, these autonomic nerves might originate from the auriculotemporal nerve and the sympathetic plexus around the supplying arteries.展开更多
In this study, the effect of cyclosporin A （CsA） eye drop on keratoconjunctivitis Sicca （KCS） and its mechanism were studied. The KCS models were established by injecting Pertussis vaccine, complete freund＇s adju...In this study, the effect of cyclosporin A （CsA） eye drop on keratoconjunctivitis Sicca （KCS） and its mechanism were studied. The KCS models were established by injecting Pertussis vaccine, complete freund＇s adjuvant （CFA） and antigen of conjunctiva from isotype mice. Then the KCS models were treated with cyclosporin A eye drop. Changes in breaking-up time （BUT）, lacrimal secretion in 30 min and diversion in 24 h were measured. The percentage of beaker cells, the lymphocytic infiltration in conjunctiva were observed. The expression levels of Aquaporin-3 （AQP3） in conjunctiva epithelial cells, beaker cells and accessory lacrimal gland were immunohistochemically detected. The results showed that there were significant differences in BUT, the percentage of beaker cells, lacrimal secretion in 30 min, the lymphocytic infiltration and the expression of AQP3 between the experimental group and an control group. It was concluded.that CsA eye drop exerts marked therapeutic effect on KCS by inhibiting T lymph cells, increasing the goblet cells and AQP3 expression in conjunctiva.展开更多
With rich clinic experience of over 30 years, the author have treated 18 cases of sicca syndrome with the heat-removing and dampness eliminating method, and obtained satisfactory therapeutic results. A report foll... With rich clinic experience of over 30 years, the author have treated 18 cases of sicca syndrome with the heat-removing and dampness eliminating method, and obtained satisfactory therapeutic results. A report follows.……展开更多
In this paper, we presented 32 dry eyes of 16 random patients with primary Sicca Syndrome graded with rose bengal(rb), Break up time of tear film (BUT) and Schirmer 1 test (S1T). Of them, the lip biopsy and tear β2-M...In this paper, we presented 32 dry eyes of 16 random patients with primary Sicca Syndrome graded with rose bengal(rb), Break up time of tear film (BUT) and Schirmer 1 test (S1T). Of them, the lip biopsy and tear β2-M level were examined and overall studied. The results showed that the grade of dry eye was closely related with both the degree of lymphocyte infiltration of lip glands and level of tear β2-M, and indicated that our grading methed for dry eye based on rb, BUT and SIT is dependable, and the l...展开更多
Objective: to observe the effect of whole process nursing intervention in the nursing of patients with Sicca syndrome. Methods: 42 patients from June 2020 to May 2021 were taken as the analysis objectives, and they we...Objective: to observe the effect of whole process nursing intervention in the nursing of patients with Sicca syndrome. Methods: 42 patients from June 2020 to May 2021 were taken as the analysis objectives, and they were randomly divided into the first group (general nursing intervention) and the second groups (whole-process nursing intervention) according to the admission number. Results: (1) in the comparison of quality of life and emotional state scores of the first group and the second group, the scores of the first group were 75.36±4.28 (points) and 50.38±4.19 (points) respectively, and the scores of the second group were 89.63±4.55 (points) and 39.85±3.76 (points) respectively (t = 18.813, P = 0.000). (2) In the comparison of satisfaction and complication rate between the first group and the second group, the first group were 76.19% and 33.33% respectively, and the second group were 95.23% and 4.76% respectively (χ2 = 8.691, P = 0.000). There was a difference between the two groups. Conclusion: the effect of whole course nursing intervention in the nursing of patients with Sicca syndrome is excellent and worthy of recommendation.展开更多
目的:分析全球干眼的研究现状、研究热点及趋势,以期为干眼领域相关研究者提供理论依据及参考,促进该领域的进一步发展。方法:检索中国知网(CNKI)数据库、万方医学数据库、维普数据库、Web of Science核心合集数据库、PubMed数据库自建...目的:分析全球干眼的研究现状、研究热点及趋势,以期为干眼领域相关研究者提供理论依据及参考,促进该领域的进一步发展。方法:检索中国知网(CNKI)数据库、万方医学数据库、维普数据库、Web of Science核心合集数据库、PubMed数据库自建库至2025-07-10已发表的干眼相关文献,并通过CiteSpace 6.2.R3和VOSviewer软件对国家/发文机构、研究作者、高频关键词为分析节点进行可视化分析。结果:目前全球干眼的相关研究已形成各个国家相应的科研团体,发文量位于前3位的国家分别为美国(3956篇)、中国(2255篇)、日本(1053篇);全球研究机构发文量最多的是日本的庆应义塾大学(395篇),其次是美国的哈佛大学(243篇)、哈佛医学院(242篇);国内发文量位于前3位的研究机构分别为首都医科大学附属北京同仁医院(83篇)、中山大学中山眼科中心(67篇)、南昌大学第一附属医院(63篇)。中英文高频关键词及爆点关键词分析结果显示:人工智能、强脉冲光治疗、干眼动物疾病模型、病理机制及药物递送为研究热点。结论:全球干眼临床研究以人工智能诊断技术及强脉冲光治疗为研究热点及趋势;基础研究以干眼动物模型、氧化应激等病理机制及干眼新型药物研发为热点及趋势。展开更多
Objective To compare the clinical efficacy of acupuncture therapy and acupuncture combined with pyonex in treatment of xerophthalmia. Methods Eighty-eight xerophthalmia patients were randomly divided into group A （pe...Objective To compare the clinical efficacy of acupuncture therapy and acupuncture combined with pyonex in treatment of xerophthalmia. Methods Eighty-eight xerophthalmia patients were randomly divided into group A （periocular acupuncture） and group B （acupuncture combined with pyonex）. The treatment was conducted once a day, twelve days were one course of treatment, and two courses were needed in total. The changes of symptom score of eyes, Schirmer I test （SIT） and break-up time （BUT） of patients in the two groups before and after treatment were observed. Results The symptom score of eyes （8.36＋2.54 vs. 5.36_＋2.65）, SIT （5.82＋4.61 vs. 8.33＋4.24） and BUT （5.92＋2.03 vs. 6.78＋2.46） of patients in the two groups after treatment were improved when compared with those before treatment. The total effective rate of group B was superior to that of group A （86.3% vs. 63.6%）（all P〈0.05）. Conclusion The efficacy of acupuncture combined with pyonex in treatment of xerophthalmia is significant, which can effectively improve the symptoms of xerophthalmia, and is superior to simple periocular acupuncture in terms of SIT and BUT.展开更多
基金supported by grants from the National Natural Science Foundation of China(No.81671005 and 81470756)
文摘Autologous submandibular gland（SMG） transplantation has been proved to ameliorate the discomforts in patients with severe keratoconjunctivitis sicca. The transplanted glands underwent a hypofunctional period and then restored secretion spontaneously.This study aims to investigate whether autonomic nerves reinnervate the grafts and contribute to the functional recovery, and further determine the origin of these nerves. Parts of the transplanted SMGs were collected from the epiphora patients, and a rabbit SMG transplantation model was established to fulfill the serial observation on the transplanted glands with time. The results showed that autonomic nerves distributed in the transplanted SMGs and parasympathetic ganglionic cells were observed in the stroma of the glands. Low-dense and unevenly distributed cholinergic axons, severe acinar atrophy and fibrosis were visible in the patients＇ glands 4–6 months post-transplantation, whereas the cholinergic axon density and acinar area were increased with time. The acinar area or the secretory flow rate of the transplanted glands was statistically correlated with the cholinergic axon density in the rabbit model, respectively. Meanwhile, large cholinergic nerve trunks were found to locate in the temporal fascia lower to the gland, and sympathetic plexus concomitant with the arteries was observed both in the adjacent fascia and in the stroma of the glands. In summary, the transplanted SMGs are reinnervated by autonomic nerves and the cholinergic nerves play a role in the morphological and functional restoration of the glands. Moreover, these autonomic nerves might originate from the auriculotemporal nerve and the sympathetic plexus around the supplying arteries.
文摘In this study, the effect of cyclosporin A （CsA） eye drop on keratoconjunctivitis Sicca （KCS） and its mechanism were studied. The KCS models were established by injecting Pertussis vaccine, complete freund＇s adjuvant （CFA） and antigen of conjunctiva from isotype mice. Then the KCS models were treated with cyclosporin A eye drop. Changes in breaking-up time （BUT）, lacrimal secretion in 30 min and diversion in 24 h were measured. The percentage of beaker cells, the lymphocytic infiltration in conjunctiva were observed. The expression levels of Aquaporin-3 （AQP3） in conjunctiva epithelial cells, beaker cells and accessory lacrimal gland were immunohistochemically detected. The results showed that there were significant differences in BUT, the percentage of beaker cells, lacrimal secretion in 30 min, the lymphocytic infiltration and the expression of AQP3 between the experimental group and an control group. It was concluded.that CsA eye drop exerts marked therapeutic effect on KCS by inhibiting T lymph cells, increasing the goblet cells and AQP3 expression in conjunctiva.
文摘 With rich clinic experience of over 30 years, the author have treated 18 cases of sicca syndrome with the heat-removing and dampness eliminating method, and obtained satisfactory therapeutic results. A report follows.……
文摘In this paper, we presented 32 dry eyes of 16 random patients with primary Sicca Syndrome graded with rose bengal(rb), Break up time of tear film (BUT) and Schirmer 1 test (S1T). Of them, the lip biopsy and tear β2-M level were examined and overall studied. The results showed that the grade of dry eye was closely related with both the degree of lymphocyte infiltration of lip glands and level of tear β2-M, and indicated that our grading methed for dry eye based on rb, BUT and SIT is dependable, and the l...
文摘Objective: to observe the effect of whole process nursing intervention in the nursing of patients with Sicca syndrome. Methods: 42 patients from June 2020 to May 2021 were taken as the analysis objectives, and they were randomly divided into the first group (general nursing intervention) and the second groups (whole-process nursing intervention) according to the admission number. Results: (1) in the comparison of quality of life and emotional state scores of the first group and the second group, the scores of the first group were 75.36±4.28 (points) and 50.38±4.19 (points) respectively, and the scores of the second group were 89.63±4.55 (points) and 39.85±3.76 (points) respectively (t = 18.813, P = 0.000). (2) In the comparison of satisfaction and complication rate between the first group and the second group, the first group were 76.19% and 33.33% respectively, and the second group were 95.23% and 4.76% respectively (χ2 = 8.691, P = 0.000). There was a difference between the two groups. Conclusion: the effect of whole course nursing intervention in the nursing of patients with Sicca syndrome is excellent and worthy of recommendation.
文摘目的:分析全球干眼的研究现状、研究热点及趋势,以期为干眼领域相关研究者提供理论依据及参考,促进该领域的进一步发展。方法:检索中国知网(CNKI)数据库、万方医学数据库、维普数据库、Web of Science核心合集数据库、PubMed数据库自建库至2025-07-10已发表的干眼相关文献,并通过CiteSpace 6.2.R3和VOSviewer软件对国家/发文机构、研究作者、高频关键词为分析节点进行可视化分析。结果:目前全球干眼的相关研究已形成各个国家相应的科研团体,发文量位于前3位的国家分别为美国(3956篇)、中国(2255篇)、日本(1053篇);全球研究机构发文量最多的是日本的庆应义塾大学(395篇),其次是美国的哈佛大学(243篇)、哈佛医学院(242篇);国内发文量位于前3位的研究机构分别为首都医科大学附属北京同仁医院(83篇)、中山大学中山眼科中心(67篇)、南昌大学第一附属医院(63篇)。中英文高频关键词及爆点关键词分析结果显示:人工智能、强脉冲光治疗、干眼动物疾病模型、病理机制及药物递送为研究热点。结论:全球干眼临床研究以人工智能诊断技术及强脉冲光治疗为研究热点及趋势;基础研究以干眼动物模型、氧化应激等病理机制及干眼新型药物研发为热点及趋势。
文摘Objective To compare the clinical efficacy of acupuncture therapy and acupuncture combined with pyonex in treatment of xerophthalmia. Methods Eighty-eight xerophthalmia patients were randomly divided into group A （periocular acupuncture） and group B （acupuncture combined with pyonex）. The treatment was conducted once a day, twelve days were one course of treatment, and two courses were needed in total. The changes of symptom score of eyes, Schirmer I test （SIT） and break-up time （BUT） of patients in the two groups before and after treatment were observed. Results The symptom score of eyes （8.36＋2.54 vs. 5.36_＋2.65）, SIT （5.82＋4.61 vs. 8.33＋4.24） and BUT （5.92＋2.03 vs. 6.78＋2.46） of patients in the two groups after treatment were improved when compared with those before treatment. The total effective rate of group B was superior to that of group A （86.3% vs. 63.6%）（all P〈0.05）. Conclusion The efficacy of acupuncture combined with pyonex in treatment of xerophthalmia is significant, which can effectively improve the symptoms of xerophthalmia, and is superior to simple periocular acupuncture in terms of SIT and BUT.
