The undrained shear strength （su） of fine-grained soils that can be measured in situ and in laboratory isone of the key geotechnical parameters. The unconfined compression test （UCT） is widely used in laboratoryto...The undrained shear strength （su） of fine-grained soils that can be measured in situ and in laboratory isone of the key geotechnical parameters. The unconfined compression test （UCT） is widely used in laboratoryto measure this parameter due to its simplicity; however, it is severely affected by sampledisturbance. The vane shear test （VST） technique that is less sensitive to sample disturbance involves acorrection factor against the soil plasticity, commonly known as the Bjerrum＇s correction factor, m. Thisstudy aims to reevaluate the Bjerrum＇s correction factor in consideration of a different approach and arelatively new method of testing. Atterberg limits test, miniature VST, and reverse extrusion test （RET）were conducted on 120 remolded samples. The effect of soil plasticity on undrained shear strength wasexamined using the liquidity index instead of Bjerrum＇s correction factor. In comparison with the resultobatined using the Bjerrum＇s correction factor, the undrained shear strength was better representedwhen su values were correlated with the liquidity index. The results were validated by the RET, whichwas proven to take into account soil plasticity with a reliable degree of accuracy. This study also showsthat the RET has strong promise as a new tool for testing undrained shear strength of fine-grained soils.展开更多
The caustic method is applied to compressive shear experiment and used to detect the stress intensity factors of cracks prefabricated on plexiglass sample. Loading, friction of crack planes and influence among cracks ...The caustic method is applied to compressive shear experiment and used to detect the stress intensity factors of cracks prefabricated on plexiglass sample. Loading, friction of crack planes and influence among cracks are not needed to know as they are combined and transformed into the caustic shadow used in detecting the stress intensity factor. Even boundary condition is not necessary. Therefore it is effective to determine the stress intensity factor of compressive shear crack.展开更多
Previous researches on the mixed mode fracture initiation criteria were mostly focused on opening mode fracture. In this study, the authors proposed a new criterion for mixed mode sliding fracture initiation, which is...Previous researches on the mixed mode fracture initiation criteria were mostly focused on opening mode fracture. In this study, the authors proposed a new criterion for mixed mode sliding fracture initiation, which is the maximum twin shear stress factor criterion. The authors studied a finite width plate with central slant crack, subject to a far field uniform uniaxial tensile or compressive stress.展开更多
Retaining walls have been used in many construction projects such as for road and inclined surfaces protection. The damage caused by an earthquake depends on the fundamental frequency, amplitude and the duration of th...Retaining walls have been used in many construction projects such as for road and inclined surfaces protection. The damage caused by an earthquake depends on the fundamental frequency, amplitude and the duration of the seismic motion. These parameters strongly depend on the seismic properties of the layers that are near the surface. In the study of retaining walls, in addition to the infl uence of soil, the infl uence of topography is also important. In the present study, site response analysis is performed by using fi nite element software PLAXIS to obtain the eff ect of various factors such as embedded length of the sheet pile, underground water table, length and angle of the nail, shear wave velocity of soil on site eff ect and dynamic response. Moreover, for better understanding of the eff ect of the above parameters, the stability analysis was performed by using shear reduction method. The results show that an increase in the embedded length of the sheet pile and the length of nailing causes an increase in the amplifi cation factor. Moreover, for shear-wave velocity in the range of 200- 600 m/s, the amplifi cation factor increases with increase of the shear-wave velocity due to the decrease of nonlinear behavior.展开更多
Based on the complex variable method, the analytical solutions of stress functions and stress intensity factors（SIFs） are provided for the plane problem of two collinear edge cracks emanating from an elliptical hole...Based on the complex variable method, the analytical solutions of stress functions and stress intensity factors（SIFs） are provided for the plane problem of two collinear edge cracks emanating from an elliptical hole in an infinite plate under shear. The stress distribution along the horizontal axis is given in graphical forms, which conforms to Saint-Venant＇s principle. The influences of crack length and ellipse shape on the stress intensity factors are evaluated. Comparing the analytical solutions with finite element method（FEM） results shows good coincidence. These numerical examples show that the present solutions are accurate.展开更多
An experimental program was carried out to study the shear behavior of the reinforced concrete composite beam (RCCB) subjected to two-phase uniformly distributed load. A total of 12 reinforced concrete composite beams...An experimental program was carried out to study the shear behavior of the reinforced concrete composite beam (RCCB) subjected to two-phase uniformly distributed load. A total of 12 reinforced concrete composite beams were tested: 10 of them were the RCCB subjected to two-phase uniformly distributed load, the other 2 were the comparative reinforced concrete beams cast at the same time as the RCCB subjected to one-phase uniformly distributed load. The interface of precast unit and recast concrete was natural and rough. The test range of the main composite factors: the ratio of precast section depth to composite section depth was from 0.35 to 0.65, the ratio of first-phase load moment to precast section ultimate bearing moment was from 0.25 to 0.65. Based on the test results, the stresses of the longitudinal reinforcements and stirrups, the load-bearing properties of the interface, the crack state and the failure characteristics of the RCCB under uniformly distributed load are discussed. The effects of the stirrups, the concrete strength and the composite factors on the shear resistance of the RCCB are analyzed, and the method for evaluating the shear resistance of the RCCB is proposed.展开更多
The axisymmetric elasticity problem of cubic quasicrystal is reduced to a single higher_order partial differential equation by introducing a displacement function. Based on the work, the analytic solutions of elastic ...The axisymmetric elasticity problem of cubic quasicrystal is reduced to a single higher_order partial differential equation by introducing a displacement function. Based on the work, the analytic solutions of elastic field of cubic quasicrystal with a penny_shaped crack under the shear loading are found, and the stress intensity factor and strain energy release rate are determined.展开更多
In this paper, the crack initiation characteristics of compression-shear plane crack with hydraulic pressure were studied by using theoretical analysis and experimental verification methods. The formula derivation pro...In this paper, the crack initiation characteristics of compression-shear plane crack with hydraulic pressure were studied by using theoretical analysis and experimental verification methods. The formula derivation process of stress intensity factor of crack tip and open-type crack initiation angle and initiation strength was expounded in detail. Cement mortar specimens prefabricated with open-type crack were made for biaxial compression test. The results show that the mode I stress intensity factor is inversely proportional to the dip angle of pre-exciting crack, water pressure and crack width. The fracture toughness is most easily achieved when the dip angle of pre-exciting crack is 60°. The mode II stress intensity factor is symmetrically distributed with the dip angle and independent of the water pressure and crack width. For open-type crack, the crack initiation angle decreases with the increase of the dip angle of pre-exciting crack, water pressure and crack width;the crack initiation strength is inversely proportional to the water pressure and proportional to the lateral pressure. The research results can provide ideas for the study of crack initiation under the coupling of ground stress and osmotic pressure in tunnel engineering.展开更多
Orthotropic materials weakened by a doubly periodic array of cracks under far-field antiplane shear are investigated, where the fundamental cell contains four cracks of unequal size. By applying the mapping technique,...Orthotropic materials weakened by a doubly periodic array of cracks under far-field antiplane shear are investigated, where the fundamental cell contains four cracks of unequal size. By applying the mapping technique, the elliptical function theory and the theory of analytical function boundary value problems, a closed form solution of the whole-field stress is obtained. The exact formulae for the stress intensity factor at the crack tip and the effective antiplane shear modulus of the cracked orthotropic material are derived. A comparison with the finite element method shows the efficiency and accuracy of the present method. Several illustrative examples are provided, and an interesting phenomenon is observed, that is, the stress intensity factor and the dimensionless effective modulus are independent of the material property for a doubly periodic cracked isotropic material, but depend strongly on the material property for the doubly periodic cracked orthotropic material. Such a phenomenon for antiplane problems is similar to that for in-plane problems. The present solution can provide benchmark results for other numerical and approximate methods.展开更多
Comparison of the loss factor determination methods of the sandwich composite structure with polyethylene terephthalate core in the aspect of core material rheological parameters identification was the purpose of the ...Comparison of the loss factor determination methods of the sandwich composite structure with polyethylene terephthalate core in the aspect of core material rheological parameters identification was the purpose of the study. Three frequency bandwidths n dB: 1 dB, 2 dB, 3 dB methods, the resonant amplitude method and the fit method of the response of the one degree of freedom model system are taken into considerations. Identification procedure, according to ASTM E756-2005 [1] based on experimental studies of the forced vibrations of the composite structure was presented in the paper. To determine the function of the complex shear modulus of the core material, the Nelder-Mead method is applied. Shear modulus and loss factor identification results were presented on the plots in the frequency domain. The results in a quantitative manner set the applied methods and their practical utility in order.展开更多
The present work dealt with the estimation of geotechnical parameters and earthquakes factors of poultry feed factory project constructing at an industrial Qift city, Qena, Egypt. The geotechnical parameters were incl...The present work dealt with the estimation of geotechnical parameters and earthquakes factors of poultry feed factory project constructing at an industrial Qift city, Qena, Egypt. The geotechnical parameters were including gradation parameters, shear velocity (Vs), shear parameters (frictional angle and cohesion), and allowable bearing capacity. The earthquakes factors were including soil coefficient (S), limits of constant value for elastic response spectrum (TB and TC), and specified value for begin of the constant displacement spectrum (TD). The present study was interested also in an estimation of design ground acceleration (ag). To achieve these objectives, five mechanical wash boreholes were conducted at ten meter depth. Fifty disturbed samples were collected. Geotechnical laboratory tests were carried out like grain size analyses, direct shear box, and shear velocity (Vs). Standard penetration test (SPT) as geotechnical field test was conducted. The results showed that the studied soils were classified as well graded and poorly graded sands (SP and SW) according to the unified soil classification system (USCS). The earthquakes factors including S, TB, TC, and TD were 1.80, 0.10, 0.30, and 1.20 respectively. The ag-value of the studied area was 0.10. According to Egyptian code for vibration and dynamic load foundations, the studied project area was classified as low potential seismic. According to Egyptian code for shallow foundation, the allowable bearing capacity of the studied sands ranging from 1.5 to 3 kg/cm2 at shallow foundation width must be not less than one meter. Shallow foundations like isolated footing or structural mat were recommended.展开更多
AIM:To explore ex vivo the role of bone morphogenetic protein-4(BMP-4) and transforming growth factorbeta1(TGF-β1) in acute valvular response to fluid shear stress(FSS) abnormalities.METHODS:Porcine valve leaflets we...AIM:To explore ex vivo the role of bone morphogenetic protein-4(BMP-4) and transforming growth factorbeta1(TGF-β1) in acute valvular response to fluid shear stress(FSS) abnormalities.METHODS:Porcine valve leaflets were subjected ex vivo to physiologic FSS,supra-physiologic FSS magnitude at normal frequency and supra-physiologic FSS frequency at normal magnitude for 48 h in a double-sided cone-and-plate bioreactor filled with standard culture medium. The role of BMP-4 and TGF-β1 in the valvular response was investigated by promoting or inhibiting the downstream action of those cytokines via culture medium supplementation with BMP-4 or the BMP antagonist noggin,and TGF-β1 or the TGF-β1 inhibitor SB-431542,respectively. Fresh porcine leaflets were used as controls. Each experimental group consisted of six leaflet samples. Immunostaining and immunoblotting were performed to assess endothelial activation in terms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expressions,paracrine signaling in terms of BMP-4 and TGF-β1 expressions and extracellular matrix(ECM) remodeling in terms of cathepsin L,cathepsin S,metalloproteinases(MMP)-2 and MMP-9 expressions. Immunostained images were quantified by normalizing the intensities of positively stained regions by the number of cells in each image while immunoblots were quantified by densitometry. R E S U LT S :Regardless of the culture medium,physiologic FSS maintained valvular homeostasis. Tissue exposure to supra-physiologic FSS magnitude in standard medium stimulated paracrine signaling(TGF-β1:467% ± 22% vs 100% ± 6% in freshcontrols,BMP-4:258% ± 22% vs 100% ± 4% in fresh controls; P < 0.05) and ECM degradation(MMP-2:941% ± 90% vs 100% ± 19% in fresh controls,MMP-9:1219% ± 190% vs 100% ± 16% in fresh controls,cathepsin L:1187% ± 175% vs 100% ± 12% in fresh controls,cathepsin S:603% ± 88% vs 100% ± 13% in fresh controls; P < 0.05),while BMP-4 supplementation also promoted fibrosa activation and TGF-β1 inhibition reduced MMP-9 expression to the native tissue level(MMP-9:308% ± 153% with TGF-β1 inhibition vs 100% ± 16% in fresh control; P > 0.05). Supra-physiologic FSS frequency had no effect on endothelial activation and paracrine signaling regardless of the culture medium but TGF-β1 silencing attenuated FSS-induced ECM degradation via MMP-9 downregulation(MMP-9:302% ± 182% vs 100% ± 42% in fresh controls; P > 0.05).CONCLUSION:Valvular tissue is sensitive to FSS abnormalities. The TGF-β1 inhibitor SB-431542 is a potential candidate molecule for attenuating the effects of FSS abnormalities on valvular remodeling.展开更多
A 10-MHz face shear （FS） square micro- mechanical resonator based on silicon-on-insulator （SO1） technology is presented in this paper. In order to examine the improvement of quality factor as well as motional resi...A 10-MHz face shear （FS） square micro- mechanical resonator based on silicon-on-insulator （SO1） technology is presented in this paper. In order to examine the improvement of quality factor as well as motional resistance Rx in this structure, the center-stem anchor is employed in this study. The benefit of anchoring the square in the center, which is the nodal point, is that the energy losses through the anchor can be minimized. Hence, a quality factor value of 2.0 million and the motional resistance of 8.2 k~ can be obtained with an FS mode resonator via finite element （FE） simulation. The results show the significance of the FS mode in this design, not only in its structure but also in its square-extensional mode and Lame-mode. Additionally, an SOI-based fabrication process is proposed to support the design.展开更多
In this paper, we study the behavior of the solution at the crack edges for a nearly circular crack with developing cusps subject to shear loading. The problem of finding the resulting force can be written in the form...In this paper, we study the behavior of the solution at the crack edges for a nearly circular crack with developing cusps subject to shear loading. The problem of finding the resulting force can be written in the form of a hypersingular integral equation. The equation is then trans-formed into a similar equation over a circular region using conformal mapping. The equation is solved numerically for the unknown coefficients, which will later be used in finding the stress intensity factors. The sliding and tearing mode stress intensity factors are evaluated for cracks and displayed graphically. Our results seem to agree with the existing asymptotic solution.展开更多
文摘The undrained shear strength （su） of fine-grained soils that can be measured in situ and in laboratory isone of the key geotechnical parameters. The unconfined compression test （UCT） is widely used in laboratoryto measure this parameter due to its simplicity; however, it is severely affected by sampledisturbance. The vane shear test （VST） technique that is less sensitive to sample disturbance involves acorrection factor against the soil plasticity, commonly known as the Bjerrum＇s correction factor, m. Thisstudy aims to reevaluate the Bjerrum＇s correction factor in consideration of a different approach and arelatively new method of testing. Atterberg limits test, miniature VST, and reverse extrusion test （RET）were conducted on 120 remolded samples. The effect of soil plasticity on undrained shear strength wasexamined using the liquidity index instead of Bjerrum＇s correction factor. In comparison with the resultobatined using the Bjerrum＇s correction factor, the undrained shear strength was better representedwhen su values were correlated with the liquidity index. The results were validated by the RET, whichwas proven to take into account soil plasticity with a reliable degree of accuracy. This study also showsthat the RET has strong promise as a new tool for testing undrained shear strength of fine-grained soils.
基金The Specialized Funds for National Key Basic Study (G1998040704), the Dual Project of China Earthquake Admini-stration (9691309020301), and National Natural Sciences Foundation of China (46764010).
文摘The caustic method is applied to compressive shear experiment and used to detect the stress intensity factors of cracks prefabricated on plexiglass sample. Loading, friction of crack planes and influence among cracks are not needed to know as they are combined and transformed into the caustic shadow used in detecting the stress intensity factor. Even boundary condition is not necessary. Therefore it is effective to determine the stress intensity factor of compressive shear crack.
文摘Previous researches on the mixed mode fracture initiation criteria were mostly focused on opening mode fracture. In this study, the authors proposed a new criterion for mixed mode sliding fracture initiation, which is the maximum twin shear stress factor criterion. The authors studied a finite width plate with central slant crack, subject to a far field uniform uniaxial tensile or compressive stress.
文摘Retaining walls have been used in many construction projects such as for road and inclined surfaces protection. The damage caused by an earthquake depends on the fundamental frequency, amplitude and the duration of the seismic motion. These parameters strongly depend on the seismic properties of the layers that are near the surface. In the study of retaining walls, in addition to the infl uence of soil, the infl uence of topography is also important. In the present study, site response analysis is performed by using fi nite element software PLAXIS to obtain the eff ect of various factors such as embedded length of the sheet pile, underground water table, length and angle of the nail, shear wave velocity of soil on site eff ect and dynamic response. Moreover, for better understanding of the eff ect of the above parameters, the stability analysis was performed by using shear reduction method. The results show that an increase in the embedded length of the sheet pile and the length of nailing causes an increase in the amplifi cation factor. Moreover, for shear-wave velocity in the range of 200- 600 m/s, the amplifi cation factor increases with increase of the shear-wave velocity due to the decrease of nonlinear behavior.
基金co-supported by Hebei Provincial Natural Science Foundation of China(No.A2011210033)Foundation of Hebei Education Department of China(No.ZH2011116)
文摘Based on the complex variable method, the analytical solutions of stress functions and stress intensity factors（SIFs） are provided for the plane problem of two collinear edge cracks emanating from an elliptical hole in an infinite plate under shear. The stress distribution along the horizontal axis is given in graphical forms, which conforms to Saint-Venant＇s principle. The influences of crack length and ellipse shape on the stress intensity factors are evaluated. Comparing the analytical solutions with finite element method（FEM） results shows good coincidence. These numerical examples show that the present solutions are accurate.
基金Part of the scientific research project(No.COE9401)sponsored by the Science Foundation of the State Key Laboratory of CoastalOffshore Engineering of Dalian University of Technology
文摘An experimental program was carried out to study the shear behavior of the reinforced concrete composite beam (RCCB) subjected to two-phase uniformly distributed load. A total of 12 reinforced concrete composite beams were tested: 10 of them were the RCCB subjected to two-phase uniformly distributed load, the other 2 were the comparative reinforced concrete beams cast at the same time as the RCCB subjected to one-phase uniformly distributed load. The interface of precast unit and recast concrete was natural and rough. The test range of the main composite factors: the ratio of precast section depth to composite section depth was from 0.35 to 0.65, the ratio of first-phase load moment to precast section ultimate bearing moment was from 0.25 to 0.65. Based on the test results, the stresses of the longitudinal reinforcements and stirrups, the load-bearing properties of the interface, the crack state and the failure characteristics of the RCCB under uniformly distributed load are discussed. The effects of the stirrups, the concrete strength and the composite factors on the shear resistance of the RCCB are analyzed, and the method for evaluating the shear resistance of the RCCB is proposed.
文摘The axisymmetric elasticity problem of cubic quasicrystal is reduced to a single higher_order partial differential equation by introducing a displacement function. Based on the work, the analytic solutions of elastic field of cubic quasicrystal with a penny_shaped crack under the shear loading are found, and the stress intensity factor and strain energy release rate are determined.
文摘In this paper, the crack initiation characteristics of compression-shear plane crack with hydraulic pressure were studied by using theoretical analysis and experimental verification methods. The formula derivation process of stress intensity factor of crack tip and open-type crack initiation angle and initiation strength was expounded in detail. Cement mortar specimens prefabricated with open-type crack were made for biaxial compression test. The results show that the mode I stress intensity factor is inversely proportional to the dip angle of pre-exciting crack, water pressure and crack width. The fracture toughness is most easily achieved when the dip angle of pre-exciting crack is 60°. The mode II stress intensity factor is symmetrically distributed with the dip angle and independent of the water pressure and crack width. For open-type crack, the crack initiation angle decreases with the increase of the dip angle of pre-exciting crack, water pressure and crack width;the crack initiation strength is inversely proportional to the water pressure and proportional to the lateral pressure. The research results can provide ideas for the study of crack initiation under the coupling of ground stress and osmotic pressure in tunnel engineering.
基金supported by the National Natural Science Foundation of China (No.10672008).
文摘Orthotropic materials weakened by a doubly periodic array of cracks under far-field antiplane shear are investigated, where the fundamental cell contains four cracks of unequal size. By applying the mapping technique, the elliptical function theory and the theory of analytical function boundary value problems, a closed form solution of the whole-field stress is obtained. The exact formulae for the stress intensity factor at the crack tip and the effective antiplane shear modulus of the cracked orthotropic material are derived. A comparison with the finite element method shows the efficiency and accuracy of the present method. Several illustrative examples are provided, and an interesting phenomenon is observed, that is, the stress intensity factor and the dimensionless effective modulus are independent of the material property for a doubly periodic cracked isotropic material, but depend strongly on the material property for the doubly periodic cracked orthotropic material. Such a phenomenon for antiplane problems is similar to that for in-plane problems. The present solution can provide benchmark results for other numerical and approximate methods.
文摘Comparison of the loss factor determination methods of the sandwich composite structure with polyethylene terephthalate core in the aspect of core material rheological parameters identification was the purpose of the study. Three frequency bandwidths n dB: 1 dB, 2 dB, 3 dB methods, the resonant amplitude method and the fit method of the response of the one degree of freedom model system are taken into considerations. Identification procedure, according to ASTM E756-2005 [1] based on experimental studies of the forced vibrations of the composite structure was presented in the paper. To determine the function of the complex shear modulus of the core material, the Nelder-Mead method is applied. Shear modulus and loss factor identification results were presented on the plots in the frequency domain. The results in a quantitative manner set the applied methods and their practical utility in order.
文摘The present work dealt with the estimation of geotechnical parameters and earthquakes factors of poultry feed factory project constructing at an industrial Qift city, Qena, Egypt. The geotechnical parameters were including gradation parameters, shear velocity (Vs), shear parameters (frictional angle and cohesion), and allowable bearing capacity. The earthquakes factors were including soil coefficient (S), limits of constant value for elastic response spectrum (TB and TC), and specified value for begin of the constant displacement spectrum (TD). The present study was interested also in an estimation of design ground acceleration (ag). To achieve these objectives, five mechanical wash boreholes were conducted at ten meter depth. Fifty disturbed samples were collected. Geotechnical laboratory tests were carried out like grain size analyses, direct shear box, and shear velocity (Vs). Standard penetration test (SPT) as geotechnical field test was conducted. The results showed that the studied soils were classified as well graded and poorly graded sands (SP and SW) according to the unified soil classification system (USCS). The earthquakes factors including S, TB, TC, and TD were 1.80, 0.10, 0.30, and 1.20 respectively. The ag-value of the studied area was 0.10. According to Egyptian code for vibration and dynamic load foundations, the studied project area was classified as low potential seismic. According to Egyptian code for shallow foundation, the allowable bearing capacity of the studied sands ranging from 1.5 to 3 kg/cm2 at shallow foundation width must be not less than one meter. Shallow foundations like isolated footing or structural mat were recommended.
基金Supported by American Heart Association Scientist Development Grant,No.11SDG7600103
文摘AIM:To explore ex vivo the role of bone morphogenetic protein-4(BMP-4) and transforming growth factorbeta1(TGF-β1) in acute valvular response to fluid shear stress(FSS) abnormalities.METHODS:Porcine valve leaflets were subjected ex vivo to physiologic FSS,supra-physiologic FSS magnitude at normal frequency and supra-physiologic FSS frequency at normal magnitude for 48 h in a double-sided cone-and-plate bioreactor filled with standard culture medium. The role of BMP-4 and TGF-β1 in the valvular response was investigated by promoting or inhibiting the downstream action of those cytokines via culture medium supplementation with BMP-4 or the BMP antagonist noggin,and TGF-β1 or the TGF-β1 inhibitor SB-431542,respectively. Fresh porcine leaflets were used as controls. Each experimental group consisted of six leaflet samples. Immunostaining and immunoblotting were performed to assess endothelial activation in terms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expressions,paracrine signaling in terms of BMP-4 and TGF-β1 expressions and extracellular matrix(ECM) remodeling in terms of cathepsin L,cathepsin S,metalloproteinases(MMP)-2 and MMP-9 expressions. Immunostained images were quantified by normalizing the intensities of positively stained regions by the number of cells in each image while immunoblots were quantified by densitometry. R E S U LT S :Regardless of the culture medium,physiologic FSS maintained valvular homeostasis. Tissue exposure to supra-physiologic FSS magnitude in standard medium stimulated paracrine signaling(TGF-β1:467% ± 22% vs 100% ± 6% in freshcontrols,BMP-4:258% ± 22% vs 100% ± 4% in fresh controls; P < 0.05) and ECM degradation(MMP-2:941% ± 90% vs 100% ± 19% in fresh controls,MMP-9:1219% ± 190% vs 100% ± 16% in fresh controls,cathepsin L:1187% ± 175% vs 100% ± 12% in fresh controls,cathepsin S:603% ± 88% vs 100% ± 13% in fresh controls; P < 0.05),while BMP-4 supplementation also promoted fibrosa activation and TGF-β1 inhibition reduced MMP-9 expression to the native tissue level(MMP-9:308% ± 153% with TGF-β1 inhibition vs 100% ± 16% in fresh control; P > 0.05). Supra-physiologic FSS frequency had no effect on endothelial activation and paracrine signaling regardless of the culture medium but TGF-β1 silencing attenuated FSS-induced ECM degradation via MMP-9 downregulation(MMP-9:302% ± 182% vs 100% ± 42% in fresh controls; P > 0.05).CONCLUSION:Valvular tissue is sensitive to FSS abnormalities. The TGF-β1 inhibitor SB-431542 is a potential candidate molecule for attenuating the effects of FSS abnormalities on valvular remodeling.
基金supported by the National Natural Science Foundation of Chinathe China Academy of Engineering Physics under Grand No.11176006
文摘A 10-MHz face shear （FS） square micro- mechanical resonator based on silicon-on-insulator （SO1） technology is presented in this paper. In order to examine the improvement of quality factor as well as motional resistance Rx in this structure, the center-stem anchor is employed in this study. The benefit of anchoring the square in the center, which is the nodal point, is that the energy losses through the anchor can be minimized. Hence, a quality factor value of 2.0 million and the motional resistance of 8.2 k~ can be obtained with an FS mode resonator via finite element （FE） simulation. The results show the significance of the FS mode in this design, not only in its structure but also in its square-extensional mode and Lame-mode. Additionally, an SOI-based fabrication process is proposed to support the design.
基金supported by the Ministry Of Higher Education Malaysia for the Fundamental Research Grant scheme,project No. 01-04-10-897FRthe NSF scholarship
文摘In this paper, we study the behavior of the solution at the crack edges for a nearly circular crack with developing cusps subject to shear loading. The problem of finding the resulting force can be written in the form of a hypersingular integral equation. The equation is then trans-formed into a similar equation over a circular region using conformal mapping. The equation is solved numerically for the unknown coefficients, which will later be used in finding the stress intensity factors. The sliding and tearing mode stress intensity factors are evaluated for cracks and displayed graphically. Our results seem to agree with the existing asymptotic solution.
