The variable salinity in stored reservoirs connected by a long channel attracts the attention of scientists worldwide,having applications in environmental and geophysical engineering.This study explores the impact of ...The variable salinity in stored reservoirs connected by a long channel attracts the attention of scientists worldwide,having applications in environmental and geophysical engineering.This study explores the impact of Navier slip conditions on exchange flows within a long channel connecting two large reservoirs of differing salinity.These horizontal density gradients drive the flow.We modify the recent one-dimensional theory,developed to avoid runaway stratification,to account for the presence of uniform slip walls.By adjusting the parameters of the horizontal density gradient based on the slip factor,we resolve analytically various flow regimes ranging from high diffusion to transitional high advection.These regimes are governed by physical parameters like channel aspect ratio,slip factor,Schmidt number,and gravitational Reynolds number.Our solutions align perfectly with ones in the no-slip limit.More importantly,under the conditions of no net flow across the channel and high Schmidt number(where stratification is concentrated near the channel’s mid-layer),we derive a closed-form solution for the slip parameter,aspect ratio,and gravitational Reynolds number that describes the interface’s behavior as a sharp interface separating two distinct zones.This interface,arising from hydrostatic wall gradients,ultimately detaches the low-and high-density regimes throughout the channel when the gravitational Reynolds number is inversely proportional to the aspect ratio for a fixed slip parameter.This phenomenon,observed previously in 2D numerical simulations with no-slip walls in the literature,is thus confirmed by our theoretical results.Our findings further demonstrate that wall slip leads to distinct and diverse flow regimes.展开更多
This study investigates the bifurcation dynamics underlying rhythmic transitions in a biophysical hippocampal–cortical neural network model.We specifically focus on the membrane potential dynamics of excitatory neuro...This study investigates the bifurcation dynamics underlying rhythmic transitions in a biophysical hippocampal–cortical neural network model.We specifically focus on the membrane potential dynamics of excitatory neurons in the hippocampal CA3 region and examine how strong coupling parameters modulate memory consolidation processes.Employing bifurcation analysis,we systematically characterize the model's complex dynamical behaviors.Subsequently,a characteristic waveform recognition algorithm enables precise feature extraction and automated detection of hippocampal sharp-wave ripples(SWRs).Our results demonstrate that neuronal rhythms exhibit a propensity for abrupt transitions near bifurcation points,facilitating the emergence of SWRs.Critically,temporal rhythmic analysis reveals that the occurrence of a bifurcation is not always sufficient for SWR formation.By integrating one-parameter bifurcation analysis with extremum analysis,we demonstrate that large-amplitude membrane potential oscillations near bifurcation points are highly conducive to SWR generation.This research elucidates the mechanistic link between changes in neuronal self-connection parameters and the evolution of rhythmic characteristics,providing deeper insights into the role of dynamical behavior in memory consolidation.展开更多
Sharp eyespot(Rhizoctonia cerealis)is a widespread soil-borne fungal disease that poses a severe threat to wheat health,and it is one of the main obstacles to achieving stable and high-quality wheat yields in China.Ou...Sharp eyespot(Rhizoctonia cerealis)is a widespread soil-borne fungal disease that poses a severe threat to wheat health,and it is one of the main obstacles to achieving stable and high-quality wheat yields in China.Our collaborative team has developed a novel,efficient,and low-toxicity fungicide named Y17991(N-(2-(2,4-bis-(trifluoromethyl)phenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide).Preliminary laboratory tests confirmed the significant inhibitory effect of this agent on R.cerealis.Large-area field trials also demonstrated its efficacy,with a disease prevention index of 83.52%,which is 1.97%greater than that of the widely used thifluzamide,and it significantly increased the wheat yield.Moreover,this study explored the impacts of Y17991 on the structure and function of the microbial community in wheat rhizosphere soil.Bacterial communities were more strongly affected than fungal communities.Y17991 significantly modulated key amino acid metabolic pathways and certain biosynthetic processes in diseased wheat rhizospheres,and it also enhanced certain biosynthetic pathways and metabolic activities in healthy wheat rhizospheres.Additionally,the application of Y17991 regulated rhizosphere metabolites,thus exerting significant control over the microbial community.We identified 15 microbial strains potentially involved in the prevention and treatment of R.cerealis,and Y17991 treatment promoted the growth of Pedobacter and Bacillus strains.These strains not only aid in plant growth but they also have the potential for disease prevention.In summary,Y17991 application at a reasonable dose does not cause significant disruption to nontarget rhizosphere microbial communities.In future studies,we will continue to investigate the impacts of Y17991 on nonmicrobial components in soil ecosystems,such as protozoa and nematodes.Our research provides a theoretical basis for the scientific application and promotion of new fungicides and offers a significant reference for establishing a comprehensive system for assessing the ecological impact of pesticides on the environment.展开更多
传统Sharpe比率将投资收益的标准差作为风险的度量,而实证研究中更关注基金的损失风险而非全部风险,这是收益标准差所无法准确刻画的。针对传统Sharpe比率的这一缺点,本文考虑了用于度量下方风险的指标风险价值VaR(Value at Risk)和预...传统Sharpe比率将投资收益的标准差作为风险的度量,而实证研究中更关注基金的损失风险而非全部风险,这是收益标准差所无法准确刻画的。针对传统Sharpe比率的这一缺点,本文考虑了用于度量下方风险的指标风险价值VaR(Value at Risk)和预期不足ES(Expected Shortfall)来替代投资收益的标准差,从而对传统Sharpe比率进行了调整。这里对VaR和ES进行计算时,运用了经验非参数估计和非参数平滑核估计两种方法。此外,本文还考虑了基金收益随时间波动的动态性,用广义自回归异方差GARCH模型对收益波动进行模拟,考察动态的VaR和ES,在实践中以动态的VaR和ES评价风险收益更加灵活。在实证研究中,本文用传统的Sharpe比率、基于VaR和ES的Sharpe比率以及基于条件VaR和条件ES的条件Sharpe比率对国内证券市场上所有26只封闭式基金在2005-2009年间的业绩进行了实证分析,分析了基金在不同指标下所体现的风险控制能力和收益水平的差别,并基于不同指标对所有基金进行了排名。此外,本文还运用协整检验考察基金收益率与市场基准指数是否存在联动关系,检验证明两者并不存在长期的均衡关系。展开更多
目的:探讨Sharp-van der Heijde(SHS)评分对类风湿关节炎(RA)的临床应用价值。方法:收集36例经临床证实的RA患者的临床及双手、腕关节X线正位平片资料,选用DAS28临床评分和SHS评分来对RA病情活动性进行量化评分,并进行统计学分析。结果...目的:探讨Sharp-van der Heijde(SHS)评分对类风湿关节炎(RA)的临床应用价值。方法:收集36例经临床证实的RA患者的临床及双手、腕关节X线正位平片资料,选用DAS28临床评分和SHS评分来对RA病情活动性进行量化评分,并进行统计学分析。结果:双手以月骨、多角骨、头骨三者骨质侵蚀性改变最严重;舟状骨、桡骨远端骨质侵蚀改变次之;第1至第4掌指关节骨质侵蚀性改变最轻。腕关节及第2至第4近侧指间关节狭窄最严重;第2至第5远侧指间关节狭窄次之;第1、第5掌指关节间隙狭窄最轻。SHS值与临床活动度评估(DAS28评分)之间存在显著相关性(rs=0.41,P<0.05),说明SHS值越高则临床症状越严重。结论:SHS值与DAS28值密切相关,可以作为判断患者病情严重程度的一个重要参考指标,有助于制订临床治疗方案和评价预后。展开更多
文摘The variable salinity in stored reservoirs connected by a long channel attracts the attention of scientists worldwide,having applications in environmental and geophysical engineering.This study explores the impact of Navier slip conditions on exchange flows within a long channel connecting two large reservoirs of differing salinity.These horizontal density gradients drive the flow.We modify the recent one-dimensional theory,developed to avoid runaway stratification,to account for the presence of uniform slip walls.By adjusting the parameters of the horizontal density gradient based on the slip factor,we resolve analytically various flow regimes ranging from high diffusion to transitional high advection.These regimes are governed by physical parameters like channel aspect ratio,slip factor,Schmidt number,and gravitational Reynolds number.Our solutions align perfectly with ones in the no-slip limit.More importantly,under the conditions of no net flow across the channel and high Schmidt number(where stratification is concentrated near the channel’s mid-layer),we derive a closed-form solution for the slip parameter,aspect ratio,and gravitational Reynolds number that describes the interface’s behavior as a sharp interface separating two distinct zones.This interface,arising from hydrostatic wall gradients,ultimately detaches the low-and high-density regimes throughout the channel when the gravitational Reynolds number is inversely proportional to the aspect ratio for a fixed slip parameter.This phenomenon,observed previously in 2D numerical simulations with no-slip walls in the literature,is thus confirmed by our theoretical results.Our findings further demonstrate that wall slip leads to distinct and diverse flow regimes.
基金supported by the National Natural Science Foundation of China(Grant Nos.12272002 and 12372061)the R&D Program of Beijing Municipal Education Commission(Grant No.KM202310009004)+1 种基金the North China University of Technology(Grant No.2023XN075-01)the Youth Research Special Project of the North China University of Technology(Grant No.2025NCUTYRSP051)。
文摘This study investigates the bifurcation dynamics underlying rhythmic transitions in a biophysical hippocampal–cortical neural network model.We specifically focus on the membrane potential dynamics of excitatory neurons in the hippocampal CA3 region and examine how strong coupling parameters modulate memory consolidation processes.Employing bifurcation analysis,we systematically characterize the model's complex dynamical behaviors.Subsequently,a characteristic waveform recognition algorithm enables precise feature extraction and automated detection of hippocampal sharp-wave ripples(SWRs).Our results demonstrate that neuronal rhythms exhibit a propensity for abrupt transitions near bifurcation points,facilitating the emergence of SWRs.Critically,temporal rhythmic analysis reveals that the occurrence of a bifurcation is not always sufficient for SWR formation.By integrating one-parameter bifurcation analysis with extremum analysis,we demonstrate that large-amplitude membrane potential oscillations near bifurcation points are highly conducive to SWR generation.This research elucidates the mechanistic link between changes in neuronal self-connection parameters and the evolution of rhythmic characteristics,providing deeper insights into the role of dynamical behavior in memory consolidation.
基金supported by the National Natural Science Foundation of China(32270296)the Shenzhen Postdoctoral Scientific Research,China(77000-42100004)+1 种基金the Key Basic Research and Development Program of Hubei Province,China(2020BBA052)the Natural Science Foundation of Guangdong Province,China(2024A1515010498)and the Fundamental Research Funds for the Central Universities,Sun Yat-sen University,China.
文摘Sharp eyespot(Rhizoctonia cerealis)is a widespread soil-borne fungal disease that poses a severe threat to wheat health,and it is one of the main obstacles to achieving stable and high-quality wheat yields in China.Our collaborative team has developed a novel,efficient,and low-toxicity fungicide named Y17991(N-(2-(2,4-bis-(trifluoromethyl)phenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide).Preliminary laboratory tests confirmed the significant inhibitory effect of this agent on R.cerealis.Large-area field trials also demonstrated its efficacy,with a disease prevention index of 83.52%,which is 1.97%greater than that of the widely used thifluzamide,and it significantly increased the wheat yield.Moreover,this study explored the impacts of Y17991 on the structure and function of the microbial community in wheat rhizosphere soil.Bacterial communities were more strongly affected than fungal communities.Y17991 significantly modulated key amino acid metabolic pathways and certain biosynthetic processes in diseased wheat rhizospheres,and it also enhanced certain biosynthetic pathways and metabolic activities in healthy wheat rhizospheres.Additionally,the application of Y17991 regulated rhizosphere metabolites,thus exerting significant control over the microbial community.We identified 15 microbial strains potentially involved in the prevention and treatment of R.cerealis,and Y17991 treatment promoted the growth of Pedobacter and Bacillus strains.These strains not only aid in plant growth but they also have the potential for disease prevention.In summary,Y17991 application at a reasonable dose does not cause significant disruption to nontarget rhizosphere microbial communities.In future studies,we will continue to investigate the impacts of Y17991 on nonmicrobial components in soil ecosystems,such as protozoa and nematodes.Our research provides a theoretical basis for the scientific application and promotion of new fungicides and offers a significant reference for establishing a comprehensive system for assessing the ecological impact of pesticides on the environment.
文摘传统Sharpe比率将投资收益的标准差作为风险的度量,而实证研究中更关注基金的损失风险而非全部风险,这是收益标准差所无法准确刻画的。针对传统Sharpe比率的这一缺点,本文考虑了用于度量下方风险的指标风险价值VaR(Value at Risk)和预期不足ES(Expected Shortfall)来替代投资收益的标准差,从而对传统Sharpe比率进行了调整。这里对VaR和ES进行计算时,运用了经验非参数估计和非参数平滑核估计两种方法。此外,本文还考虑了基金收益随时间波动的动态性,用广义自回归异方差GARCH模型对收益波动进行模拟,考察动态的VaR和ES,在实践中以动态的VaR和ES评价风险收益更加灵活。在实证研究中,本文用传统的Sharpe比率、基于VaR和ES的Sharpe比率以及基于条件VaR和条件ES的条件Sharpe比率对国内证券市场上所有26只封闭式基金在2005-2009年间的业绩进行了实证分析,分析了基金在不同指标下所体现的风险控制能力和收益水平的差别,并基于不同指标对所有基金进行了排名。此外,本文还运用协整检验考察基金收益率与市场基准指数是否存在联动关系,检验证明两者并不存在长期的均衡关系。
文摘目的:探讨Sharp-van der Heijde(SHS)评分对类风湿关节炎(RA)的临床应用价值。方法:收集36例经临床证实的RA患者的临床及双手、腕关节X线正位平片资料,选用DAS28临床评分和SHS评分来对RA病情活动性进行量化评分,并进行统计学分析。结果:双手以月骨、多角骨、头骨三者骨质侵蚀性改变最严重;舟状骨、桡骨远端骨质侵蚀改变次之;第1至第4掌指关节骨质侵蚀性改变最轻。腕关节及第2至第4近侧指间关节狭窄最严重;第2至第5远侧指间关节狭窄次之;第1、第5掌指关节间隙狭窄最轻。SHS值与临床活动度评估(DAS28评分)之间存在显著相关性(rs=0.41,P<0.05),说明SHS值越高则临床症状越严重。结论:SHS值与DAS28值密切相关,可以作为判断患者病情严重程度的一个重要参考指标,有助于制订临床治疗方案和评价预后。
