Objective: To examine the trajectory of psychosomatic symptoms and to explore the impact of psychosomatic symptoms on setup error in patients undergoing breast cancer radiotherapy.Methods: A total of 102 patients with...Objective: To examine the trajectory of psychosomatic symptoms and to explore the impact of psychosomatic symptoms on setup error in patients undergoing breast cancer radiotherapy.Methods: A total of 102 patients with early breast cancer who received initial radiotherapy were consecutively recruited. The M.D. Anderson Symptom Inventory(MDASI) and three different anxiety scales, i.e., the Self-Rating Anxiety Scale(SAS), State-Trait Anxiety Inventory(STAI), and Anxiety Sensitivity Index(ASI), were used in this study. The radiotherapy setup errors were measured in millimetres by comparing the real-time isocratic verification film during radiotherapy with the digitally reconstructed radiograph(DRR). Patients completed the assessment at three time points: before the initial radiotherapy(T1), before the middle radiotherapy(T2), and before the last radiotherapy(T3).Results: The SAS and STAI-State scores of breast cancer patients at T1 were significantly higher than those at T2 and T3(F=24.44, P<0.001;F=30.25, P<0.001). The core symptoms of MDASI were positively correlated with anxiety severity. The setup errors of patients with high SAS scores were greater than those of patients with low anxiety levels at T1(Z=-2.01, P=0.044). We also found that higher SAS scores were associated with a higher risk of radiotherapy setup errors at T1(B=0.458, P<0.05).Conclusions: This study seeks to identify treatment-related psychosomatic symptoms and mitigate their impact on patients and treatment. Patients with early breast cancer experienced the highest level of anxiety before the initial radiotherapy, and then, anxiety levels declined. Patients with high somatic symptoms of anxiety may have a higher risk of radiotherapy setup errors.展开更多
Objective： The aim of this work was to quantify the extent of set-up errors to conduct a quality assurance （QA） aspect of treatment delivery, verification of the treatment field＇s position on different days using ...Objective： The aim of this work was to quantify the extent of set-up errors to conduct a quality assurance （QA） aspect of treatment delivery, verification of the treatment field＇s position on different days using electronic portal. Methods： This study was carried out on 12 patients, treated for pelvis tumor; and total of 240 images obtained by electronic portal image device （EPID） were analyzed. The EPIs acquire using EPID attached to the Siemens linear accelerator. The anatomy match- ing software （Theraview） was used and displacement in two dimensions were noted for each treatment field to study patient setup errors. Results： The percentages of mean deviations less than 5 mm in X direction were 65% ＆ 92%, from 5-10 mm were 31% ＆ 19% and more than 10 mm were 11% ＆ 9% forNP and lateral direction respectively. The percentages of mean deviations less than 5 mm in Y direction were 65% ＆ 63%, from 5-10 mm were 33% ＆ 28% and more than 10 mm were 22% ＆ 29%. The mean deviations in 2D-vector errors were 〈 5 mm in 47% and 46%, 5-10 mm in 36% and 37% and 〉 10 mm in 37% and 37% of images in the NP and lateral direction respectively. Conclusion： The results revealed that the ranges of set up errors are immobilization method to improve reproducibility. The observed variations were not within the limits..展开更多
Objective:To evaluate the accuracy of six-dimensional(6D)treatment couches in minimizing setup errors compared with three-dimensional(3D)treatment couches during radiotherapy for lung cancer patients with brain metast...Objective:To evaluate the accuracy of six-dimensional(6D)treatment couches in minimizing setup errors compared with three-dimensional(3D)treatment couches during radiotherapy for lung cancer patients with brain metastases.Methods:A retrospective analysis was conducted on 40 lung cancer patients with brain metastases who received stereotactic radiotherapy(SRS/SRT)for brain metastases.The cohort was divided into two groups based on the availability of treatment units at the time of planning:20 patients were treated using a 3D couch,and 20 patients with a 6D couch.Daily cone-beam computed tomography(CBCT)registration was used to measure residual setup errors in the x,y,and z axes at two key cranial anatomical landmarks,specifically the internal acoustic meatus(IAM)and crista galli(CG),for both groups.The Shapiro-Wilk test was applied to assess the normality of the data,and the Mann-Whitney U test was performed to determine statistical differences between the two groups,with Bonferroni correction for multiple comparisons.Results:Baseline data indicated that the two groups were well-balanced in terms of gender,age,and distribution of pathological types,number of brain metastases,maximum metastases volume,and relative distance between metastases and isocenter(P>0.05).Setup error data in all directions(IAM_x/y/z,CG_x/y/z)did not follow a normal distribution(P<0.05).The Mann-Whitney U test revealed that setup errors in the 6D group were significantly smaller than those in the 3D group across all directions(IAM_x/y/z,CG_x/y/z,all P<0.001).The mean error reduction exceeded 1 mm in all directions,with the most significant difference observed in the CG_X direction:2.2(1.3,3.3)mm in the 3D group versus 0.3(0.2,0.5)mm in the 6D group,representing a difference of 1.9 mm.Conclusion:The six-dimensional(6D)treatment couch effectively minimizes residual setup errors,especially rotational ones,in radiotherapy for lung cancer patients with brain metastases.展开更多
文摘Objective: To examine the trajectory of psychosomatic symptoms and to explore the impact of psychosomatic symptoms on setup error in patients undergoing breast cancer radiotherapy.Methods: A total of 102 patients with early breast cancer who received initial radiotherapy were consecutively recruited. The M.D. Anderson Symptom Inventory(MDASI) and three different anxiety scales, i.e., the Self-Rating Anxiety Scale(SAS), State-Trait Anxiety Inventory(STAI), and Anxiety Sensitivity Index(ASI), were used in this study. The radiotherapy setup errors were measured in millimetres by comparing the real-time isocratic verification film during radiotherapy with the digitally reconstructed radiograph(DRR). Patients completed the assessment at three time points: before the initial radiotherapy(T1), before the middle radiotherapy(T2), and before the last radiotherapy(T3).Results: The SAS and STAI-State scores of breast cancer patients at T1 were significantly higher than those at T2 and T3(F=24.44, P<0.001;F=30.25, P<0.001). The core symptoms of MDASI were positively correlated with anxiety severity. The setup errors of patients with high SAS scores were greater than those of patients with low anxiety levels at T1(Z=-2.01, P=0.044). We also found that higher SAS scores were associated with a higher risk of radiotherapy setup errors at T1(B=0.458, P<0.05).Conclusions: This study seeks to identify treatment-related psychosomatic symptoms and mitigate their impact on patients and treatment. Patients with early breast cancer experienced the highest level of anxiety before the initial radiotherapy, and then, anxiety levels declined. Patients with high somatic symptoms of anxiety may have a higher risk of radiotherapy setup errors.
文摘Objective： The aim of this work was to quantify the extent of set-up errors to conduct a quality assurance （QA） aspect of treatment delivery, verification of the treatment field＇s position on different days using electronic portal. Methods： This study was carried out on 12 patients, treated for pelvis tumor; and total of 240 images obtained by electronic portal image device （EPID） were analyzed. The EPIs acquire using EPID attached to the Siemens linear accelerator. The anatomy match- ing software （Theraview） was used and displacement in two dimensions were noted for each treatment field to study patient setup errors. Results： The percentages of mean deviations less than 5 mm in X direction were 65% ＆ 92%, from 5-10 mm were 31% ＆ 19% and more than 10 mm were 11% ＆ 9% forNP and lateral direction respectively. The percentages of mean deviations less than 5 mm in Y direction were 65% ＆ 63%, from 5-10 mm were 33% ＆ 28% and more than 10 mm were 22% ＆ 29%. The mean deviations in 2D-vector errors were 〈 5 mm in 47% and 46%, 5-10 mm in 36% and 37% and 〉 10 mm in 37% and 37% of images in the NP and lateral direction respectively. Conclusion： The results revealed that the ranges of set up errors are immobilization method to improve reproducibility. The observed variations were not within the limits..
文摘Objective:To evaluate the accuracy of six-dimensional(6D)treatment couches in minimizing setup errors compared with three-dimensional(3D)treatment couches during radiotherapy for lung cancer patients with brain metastases.Methods:A retrospective analysis was conducted on 40 lung cancer patients with brain metastases who received stereotactic radiotherapy(SRS/SRT)for brain metastases.The cohort was divided into two groups based on the availability of treatment units at the time of planning:20 patients were treated using a 3D couch,and 20 patients with a 6D couch.Daily cone-beam computed tomography(CBCT)registration was used to measure residual setup errors in the x,y,and z axes at two key cranial anatomical landmarks,specifically the internal acoustic meatus(IAM)and crista galli(CG),for both groups.The Shapiro-Wilk test was applied to assess the normality of the data,and the Mann-Whitney U test was performed to determine statistical differences between the two groups,with Bonferroni correction for multiple comparisons.Results:Baseline data indicated that the two groups were well-balanced in terms of gender,age,and distribution of pathological types,number of brain metastases,maximum metastases volume,and relative distance between metastases and isocenter(P>0.05).Setup error data in all directions(IAM_x/y/z,CG_x/y/z)did not follow a normal distribution(P<0.05).The Mann-Whitney U test revealed that setup errors in the 6D group were significantly smaller than those in the 3D group across all directions(IAM_x/y/z,CG_x/y/z,all P<0.001).The mean error reduction exceeded 1 mm in all directions,with the most significant difference observed in the CG_X direction:2.2(1.3,3.3)mm in the 3D group versus 0.3(0.2,0.5)mm in the 6D group,representing a difference of 1.9 mm.Conclusion:The six-dimensional(6D)treatment couch effectively minimizes residual setup errors,especially rotational ones,in radiotherapy for lung cancer patients with brain metastases.
