An announcement was made on November 4, 1994, on making the China National Nonferrous Industry Corporation one of the three State holding corporations for experiment at a national conference on experimenting on modern...An announcement was made on November 4, 1994, on making the China National Nonferrous Industry Corporation one of the three State holding corporations for experiment at a national conference on experimenting on modern enterprises sponsored by the State Council. The appearance of State holding corporations is the result of China’s deepening economic restructuring and an important and integral part of deepening enterprise reform.展开更多
Foundling islands are also called baby safety islands. Overseas they are also called foundling protection cabins and are a place to care for abandoned babies. In June 2011, the Shijiazhuang Social Welfare Institute in...Foundling islands are also called baby safety islands. Overseas they are also called foundling protection cabins and are a place to care for abandoned babies. In June 2011, the Shijiazhuang Social Welfare Institute in Hebei Province set up a foundling island. By the end of 2013, many cities had set up such islands, which is a new measure for ensuring children rights.展开更多
Such disciplines as financial management,auditing,separated from the accounting diseipline system,have hecome anindependent professional,These two disciplines together with the original accounting diseipline,are liste...Such disciplines as financial management,auditing,separated from the accounting diseipline system,have hecome anindependent professional,These two disciplines together with the original accounting diseipline,are listed in business administration firstlevel discipline in the category of management,as the secondary discipline or professional.This paper argues that requirements are met now toset up the first level discipline of accounting professional(or class),and the three secondary discipline(or major):the accounting,financialmanagement,auditing,should be included into accounting first level discipline(or classes).Then,accounting will become first level disciplineparalleling with business administration first level.展开更多
OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 i...OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 into three groups:group A(acupuncture combined with atlantoaxial joint bone setting therapy group),group B(acupuncture group),and group C(tiapride group).After two months of treatment,the Yale global tic severity scale(YGTSS)score reduction,improvement in social function impairment,clinical efficacy,and long-term efficacy in the three groups were compared.RESULTS:After treatment,in the analysis of YGTSS score reduction,social function impairment improvement,the clinical control rate,and long-term efficacy,the results were all Group A>Group B>Group C,with a statistically significant difference(P<0.05).However,the total clinical efficacy of treatment in group A(94.9%)was not significantly different from that in group B(91.8%).Adverse reactions did not occur in groups A and B,and several adverse reactions occurred in 29%(n=58)of the group C patients.CONCLUSION:Compared with traditional drug therapy,acupuncture combined with atlantoaxial joint bone setting therapy has better clinical and long-term efficacy.This treatment strategy can improve the social function of children and prevent adverse reactions to drugs.展开更多
BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques...BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques before entry into the market.Typically,blood glucose(BG)levels are maintained at 5%below baseline to suppress endogenous insulin secretion in healthy volunteers.However,in scenarios where BG baseline is relatively low,maintaining it at 5%below baseline can increase hypoglycemic risk.Consequently,we adjusted to maintain it at 2.5%below a baseline of<4.00 mmol/L.It remains uncertain whether this adjustment impacts endogenous insulin inhibition or the PD of study insulin.AIM To evaluate and compare the PD and C-peptide status using two different target BG setting methods.METHODS Data came from euglycemic clamp trials assessing the PK/PD of insulin aspart(IAsp)in healthy participants.Target BG was set at 2.5%below baseline for those with a basal BG of<4.00 mmol/L(group A),and at 5%below baseline for others(group B).The area under the curve(AUC)of IAsp(AUC_(IAsp,0-8 h))and GIR from 0 to 8 hours(AUCGIR,0-8 h)was used to characterize the PK and PD of IAsp,respectively.The C-peptide reduction and PK/PD of IAsp were compared between the two groups.RESULTS Out of 135 subjects,15 were assigned to group A and 120 to group B;however,group B exhibited higher basal Cpeptide(1.59±0.36 vs 1.32±0.42 ng/mL,P=0.006).Following propensity score matching to adjust for basal Cpeptide differences,71 subjects(15 in group A and 56 in group B)were analyzed.No significant differences were observed in demographics,IAsp dosage,or clamp quality.Group B showed significantly higher baseline(4.35±0.21 vs 3.91±0.09 mmol/L,P<0.001),target(4.13±0.20 vs 3.81±0.08 mmol/L,P<0.001),and clamped(4.10±0.17 vs 3.80±0.06 mmol/L,P<0.001)BG levels.Both groups exhibited comparable C-peptide suppression(32.5%±10.0%vs 35.6%±12.1%,P=0.370)and similar IAsp activity(AUCGIR,0-8 h:1433±400 vs 1440±397 mg/kg,P=0.952)under nearly equivalent IAsp exposure(AUC_(IAsp,0-8 h):566±51 vs 571±85 ng/mL×h,P=0.840).CONCLUSION Maintaining BG at 2.5%below a baseline of<4.00 mmol/L did not compromise the endogenous insulin suppression nor alter the observed pharmacodynamic effects of the study insulin.展开更多
Breast cancer is the leading cause of cancer-related mortality in women globally,with its incidence continuing to rise,particularly in low-and middle-income countries,presenting a significant public health challenge w...Breast cancer is the leading cause of cancer-related mortality in women globally,with its incidence continuing to rise,particularly in low-and middle-income countries,presenting a significant public health challenge worldwide[1].According to data from the Institute for Health Metrics and Evaluation(IHME)and the World Health Organization(WHO),the gap in access to healthcare services between high-and low-income countries contributes to delayed detection,increased incidence of advanced-stage disease,and,consequently,higher mortality rates(up to 50%higher compared to high-income countries)[1,2].This translates into inequalities in access to screening and early diagnosis methods,which exacerbate the burden of this disease in low-resource settings where infrastructure,funding,and access to trained professionals are limited[3].展开更多
High temperature stress (HT) significantly reduces maize yield by impairing starch accumulation in kernels.However,the mechanism by which HT affects starch synthesis remains controversial-whether through reduced assim...High temperature stress (HT) significantly reduces maize yield by impairing starch accumulation in kernels.However,the mechanism by which HT affects starch synthesis remains controversial-whether through reduced assimilate supply or direct inhibition on kernel metabolism.To clarify these mechanisms,a heat-sensitive maize hybrid,Xianyu 335 (XY),was exposed to 30℃/20℃ (maximum/minimum temperature,control) and 40℃/30℃ for seven consecutive days during the seed setting stage.Synchronous pollination (SP),apical pollination (AP),and shading treatments were applied to manipulate the inherent source–sink ratio in maize plants.Results showed that apical kernel weight decreased by 11.9%under 40℃ in the SP treatment.The ^(13)C content,starch accumulation,and cell-wall invertase (CWIN) activity also declined by 15.9,36.7,and 16.4%,respectively,under HT.In the shading treatment,40℃/30℃ caused even greater reductions in^(13)C content,starch accumulation,and CWIN activity due to diminished assimilate supply.Conversely,in the AP treatment,starch content and CWIN activity increased by 22.0 and 18.5%,respectively,under 40℃/30℃,resulting in kernel weight and ^(13)C content similar to those in SP and shading treatments regardless of temperature.Consistent with apical kernels under AP,HT did not negatively affect middle kernels in either SP or shading treatments,as kernel weight and starch content remained unchanged under HT.Although all kernels were exposed to the same HT or control environment,their responses varied a lot.The impaired starch synthesis in apical kernels under HT was rescued by increasing carbon supply via AP treatment.The contrasting performance among middle kernels,apical kernels under AP,and apical kernels under SP or shading indicates that reduced carbon supply is a critical factor underlying inhibited starch accumulation.Our findings provide a theoretical basis for further understanding kernel abortion under HT.展开更多
The Shenshan Group provides important geological information which is vital in unraveling the amalgamation and subsequent rifting processes of South China.While conventional studies have asserted its formation in a su...The Shenshan Group provides important geological information which is vital in unraveling the amalgamation and subsequent rifting processes of South China.While conventional studies have asserted its formation in a subduction setting,the distinct investigation reveals the necessity for reassessment.To address this,the authors employ integrated methods encompassing petrological,zircon U-Pb geochronological,Lu-Hf isotopic and geochemical methods for sedimentary rocks from the upper Shenshan subgroup and Banxi Group.The geochemical results indicate that they were formed through the recycling deposition of intermediate-acidic igneous source material and experienced moderate chemical weathering.Additionally,both sedimentary sequences exhibit characteristics consistent with those formed in an intracontinental extensional rift setting since ca.810 Ma.The provenance analysis indicates that the upper Shenshan subgroup primarily originates from the Yangtze Domain,while the Banxi Group from both the Yangtze and Cathaysia domains.Synthesizing with previous studies,the Shenshan Group should be subdivided into the lower and upper subgroups which represent distinct tectonic backgrounds.The lower subgroup is inferred to have formed in an Early Neoproterozoic fore-arc setting,akin to the Zhoutan group.The upper subgroup corresponds to the Banxi Group,representing the Middle Neoproterozoic postorogenic rift setting,responding to the breakup of Rodinia.展开更多
Satellite image segmentation plays a crucial role in remote sensing,supporting applications such as environmental monitoring,land use analysis,and disaster management.However,traditional segmentation methods often rel...Satellite image segmentation plays a crucial role in remote sensing,supporting applications such as environmental monitoring,land use analysis,and disaster management.However,traditional segmentation methods often rely on large amounts of labeled data,which are costly and time-consuming to obtain,especially in largescale or dynamic environments.To address this challenge,we propose the Semi-Supervised Multi-View Picture Fuzzy Clustering(SS-MPFC)algorithm,which improves segmentation accuracy and robustness,particularly in complex and uncertain remote sensing scenarios.SS-MPFC unifies three paradigms:semi-supervised learning,multi-view clustering,and picture fuzzy set theory.This integration allows the model to effectively utilize a small number of labeled samples,fuse complementary information from multiple data views,and handle the ambiguity and uncertainty inherent in satellite imagery.We design a novel objective function that jointly incorporates picture fuzzy membership functions across multiple views of the data,and embeds pairwise semi-supervised constraints(must-link and cannot-link)directly into the clustering process to enhance segmentation accuracy.Experiments conducted on several benchmark satellite datasets demonstrate that SS-MPFC significantly outperforms existing state-of-the-art methods in segmentation accuracy,noise robustness,and semantic interpretability.On the Augsburg dataset,SS-MPFC achieves a Purity of 0.8158 and an Accuracy of 0.6860,highlighting its outstanding robustness and efficiency.These results demonstrate that SSMPFC offers a scalable and effective solution for real-world satellite-based monitoring systems,particularly in scenarios where rapid annotation is infeasible,such as wildfire tracking,agricultural monitoring,and dynamic urban mapping.展开更多
Using a modified numerical model with higher resolution both horizontal and vertical directions,the surface fluxes of the sensible and latent heat in the HEIFE(Heihe Field Experiment)region were diagnosed.Based on sta...Using a modified numerical model with higher resolution both horizontal and vertical directions,the surface fluxes of the sensible and latent heat in the HEIFE(Heihe Field Experiment)region were diagnosed.Based on statistical analy- sis for the diagnostic fluxes,the representativeness and location of observational stations in the HEIFE region were inves- tigated,a concrete scheme for setting up the observational stations in the HEIFE region with different underlying sur- faces are obtained and the general principle of choosing the locations of observational stations with better representativeness is proposed.展开更多
When being planted in wide areas in southern China (23°23' - 33°23' N, 98°35' - 120°19' E, sea level above 2.7 - 1285 m), Liangyoupeijiu (LYPJ), a two-line hybrid rice combination, ...When being planted in wide areas in southern China (23°23' - 33°23' N, 98°35' - 120°19' E, sea level above 2.7 - 1285 m), Liangyoupeijiu (LYPJ), a two-line hybrid rice combination, showed a seed setting rate of 75.2 - 77.2%, which was lower by 4.3 - 7.5 percent point than that of an indica hybrid rice Shanyou 63 (CK), with similar values of grain yield and coefficients of variation to CK. Sowing during 5-25th of May in Nanjing (32°3' N, 118°48' E), China, LYPJ headed before 4th September, and gave a seed setting rate of 75 - 90%, and grain yield over 1 kg/m2. If the sowing date was delayed to 14 - 15th, June, its heading date would be as late as 17th - 21st September, and seed setting rate would be declined by 10 - 15% in comparison with that on a suitable sowing date. When flowering took place at an average daily temperature range of 13.7 - 28.5℃ for five days, the spikelet fertility (SF) would be increased by 1.9- 10.7%, for each increment of 1℃. The suitable (SF≥90%) and safe (SF≥75%) temperatures for flowering stage were indicated to be 26.5℃ and 22.9℃, respectively. To get a high and stable seed set in cultivating LYPJ, it was recommended that LYPJ would be planted in the areas south of 34癗, and the favorable average daily temperature during flowering stage should be at 26 - 28℃.展开更多
The central Fujian Province, situated on the juncture of paleo-uplift of Wuyishan, Yongmei Late Paleozoic depression and the eastern volcanic rift-faulting zone, is mainly composed of the outcropped metamorphic baseme...The central Fujian Province, situated on the juncture of paleo-uplift of Wuyishan, Yongmei Late Paleozoic depression and the eastern volcanic rift-faulting zone, is mainly composed of the outcropped metamorphic basements in the Middle-Late and Early Proterozoic, which constitute two upper and lower giant thick formations of Precambrian volcanic-sedimentary cycles, respectively. The formation of Dongyan Group is an important Middle-Upper Proterozoic component, and the Dongyan Group is directly related to massive sulfide deposit in this area. In recent years, plenty of lead, zinc, copper, silver and gold deposits have been found and explored. The Precambrian paleorift setting of the central Fujian Province served as a favorite metallogenic background for the formation of large- and superlarge-scale volcanic massive sulfide (VMS) lead and zinc polymetal deposits. The Dongyan Group consists chiefly of a set of ancient volcanic sedimentary formations that are composed mainly of greenschist. Its major lithologic types comprise greenschist, marble, quartzite and granofels class including various components. The metamorphic rocks of Dongyan Group are the main composition of Middle and Upper Proterozoic volcanic-sedimentary cycle. The original rock of Dongyan Group, a stable rock association, is volcanic sedimentation and normal marine sedimentation. But the original volcanic rocks, basic and acid, are bimodal. The volcanic rocks were formed in the extensional continental rift setting.展开更多
Distributed generators now is widely used in electrical power networks, in some cases it works seasonally, and some types works at special weather conditions like photo voltaic systems and wind energy, and due to this...Distributed generators now is widely used in electrical power networks, in some cases it works seasonally, and some types works at special weather conditions like photo voltaic systems and wind energy, and due to this continuous changes in generation condition, the fault current level in network will be affected, this changes in fault current level will affect in the coordination between protection relays and to keep the coordination at right way, an adaptive protection system is required that can adaptive its setting according to generation changes, the fault current level in each case is evaluated using ETAP software, and the required relay setting in each case is also evaluated using Grey Wolf Optimizer (GWO) algorithm, and to select suitable setting which required in each condition, to select the active setting group of protection relay according to generation capacity, central protection unite can be used, and to improve protection stability and minimizing relays tripping time, a proposed method for selecting suitable backup relay is used, which leads to decrease relays tripping time and increase system stability, output settings for relays in all cases achieved our constrains.展开更多
The Mesoproterozoic Baoban Group is the oldest basement in Hainan Island and has played an important role in Columbia(Nuna)supercontinent reconstructions.The Mesoproterozoic granitic intrusions in the Baoban Group are...The Mesoproterozoic Baoban Group is the oldest basement in Hainan Island and has played an important role in Columbia(Nuna)supercontinent reconstructions.The Mesoproterozoic granitic intrusions in the Baoban Group are the most widely-exposed Precambrian magmatic rocks and are the key to understanding the tectonic settings of Hainan Island and its relationship with the South China Block and the Columbia supercontinent.New LA-ICP-MS zircon U-Pb dating on three mylonitic granite samples from the Tuwaishan and Baoban areas yield ages ranging from 1447 Ma to 1437 Ma,representing the absolute timing of the emplacement of the granitic intrusions.Combined with previously published geochronological data for rocks from the Baoban Group and regional mafic intrusions,it is concluded that the Baoban Group formed at 1460-1430 Ma,coeval with the emplacement of the granitic and mafic intrusions.New in-situ zircon LuHf isotope analyses for the three mylonitic granite samples yielded positiveε(t)values,ranging from+0.49 to+8.27,with model ages(T~C)ranging from 2181 Ma to 1687 Ma,suggesting that the granitic intrusions originated from a mixed source of Paleoproterozoic crust with juvenile crust.New zircon trace element data show characteristics of high Th/U values of 0.24-1.50,steep slopes from LREE to HREE and negative Pr,Eu anomalies with positive Ce,Sm anomalies,representing typical magmatic zircons formed in continental crust.Compared with available magmatic and detrital zircon ages from Precambrian rocks in the Cathaysia Block,Yangtze Block and western Laurentia,it is inferred that Hainan Island was separated from both the Cathaysia Block and the Yangtze Block,instead being connected with western Laurentia in the Columbia supercontinent.Considering the decreasing tendency of basin deposition time along the western margin of Laurentia,it is proposed that Hainan Island was located to the north or northwest of the Belt-Purcell Supergroup,along the western margin of Laurentia,during the breakup of the Columbia supercontinent.展开更多
To reconstruct the paleoenvironment,the petrography and geochemical compositions of the upper Permian Dalong Formation(Fm)(P_(3)d)sandstones in the Central Uplift,South Yellow Sea Basin,was investigated,after which th...To reconstruct the paleoenvironment,the petrography and geochemical compositions of the upper Permian Dalong Formation(Fm)(P_(3)d)sandstones in the Central Uplift,South Yellow Sea Basin,was investigated,after which the provenance,tectonic setting,weathering conditions,and diagenetic history were determined.The Dalong Fm is mainly composed of sandstones with a few mudstones and limestones.The petrographic analysis showed that the P_(3)d sandstones are in low maturity and could be classified into feldspar sandstone and lithic sandstone on average framework composition of Q_(63)F_(16)L_(21).The major and trace element results show that Dalong Fm sandstones are enriched in Rb and depleted in Cr and Ni compared with the upper continental crust(UCC).The chemical weathering intensity is weak to low moderate in the source area as indicated by the chemical index of alteration(CIA)and other results from a variety of methods.The diagenetic process included three main stages:eodiagenesis,mesodiagenesis,and telodiagenesis.Tectonic discrimination plots show that the source areas were an active continental margin(ACM)and a passive continental margin(PCM),which may have been related to the northward movement of the Lower Yangtze Plate(LYP)and the collision between the LYP and the North China Plate(NCP).展开更多
Research studies conducted in the healthcare sector usually examine patients’ and workers’ wellbeing as separate entities;however, recent studies have revealed significant correlations between, for example, patient ...Research studies conducted in the healthcare sector usually examine patients’ and workers’ wellbeing as separate entities;however, recent studies have revealed significant correlations between, for example, patient satisfaction, workers stress and burnout. The present study examines the relationships between patient perceived quality of care (in terms of satisfaction with regard to accessibility, organizational efficiency and humaneness of care), and workers’ perceived quality of organizational life (in term of organizational support and availability of resource and reward), quality of relationship in the work-unit (superior and coworkers), quality of relationship with patients (disproportionate client expectations and customer verbal aggression) and individual health (emotional exhaustion and depersonalization, job satisfaction). 147 workers and 132 patients from seven hospital wards in northern Italy constitute the data base for the study. Analyses showed that accessibility and humaneness of care were negatively associated with disproportionate patient expectations, patient verbal aggression, emotional exhaustion and positively associated with availability of material recourses. Moreover, accessibility was also positively associated with the organizational support while organizational efficiency with support from colleagues. Globally, the results of the present study confirm that staff wellbeing is an essential aspect in relation to the patient perception of the quality of care and supporting the assumption that healthy organizations improve the wellbeing of their workers, their organizational performance and the quality of their service at the same time.展开更多
Africa faces significant challenges in terms of material and personnel resources for oncology interventions. This is particularly evident in South Africa, where resources are divided into high- and low-resource settin...Africa faces significant challenges in terms of material and personnel resources for oncology interventions. This is particularly evident in South Africa, where resources are divided into high- and low-resource settings. High-resource settings cater to those with financial means to access private oncology facilities. However, many breast cancer patients receive care in South Africa’s low-resource settings, such as public hospital oncology clinics. Unfortunately, these settings have limited service providers and fail to offer comprehensive interventions, resulting in poor outcomes. However, recent research has highlighted the significance of socially supportive relationships in promoting healing and overall individual well-being, and spirituality has been identified as a source of positive outcomes in cancer patients. This systematic review paper explores the feasibility of implementing support group cancer care and interventions that incorporate social support networks available in community settings, and spiritual practices facilitated by traditional healers, and religious/spiritual leaders. These interventions can be provided within low-resource settings to women diagnosed with breast cancer. Inclusive participation of spouses, children, and extended family in the support group cancer care can facilitate healing for the entire system. Focusing on the strengths and resources within communities and incorporating these complementary services, can enhance the well-being and quality of life for Black African women diagnosed with breast cancer, despite low-resource settings. This approach acknowledges the potential of community-based support networks and encourages collaboration between various stakeholders, including community health educators, nurses, lay counselors, and community volunteers, to address the complex needs of these patients.展开更多
文摘An announcement was made on November 4, 1994, on making the China National Nonferrous Industry Corporation one of the three State holding corporations for experiment at a national conference on experimenting on modern enterprises sponsored by the State Council. The appearance of State holding corporations is the result of China’s deepening economic restructuring and an important and integral part of deepening enterprise reform.
文摘Foundling islands are also called baby safety islands. Overseas they are also called foundling protection cabins and are a place to care for abandoned babies. In June 2011, the Shijiazhuang Social Welfare Institute in Hebei Province set up a foundling island. By the end of 2013, many cities had set up such islands, which is a new measure for ensuring children rights.
文摘Such disciplines as financial management,auditing,separated from the accounting diseipline system,have hecome anindependent professional,These two disciplines together with the original accounting diseipline,are listed in business administration firstlevel discipline in the category of management,as the secondary discipline or professional.This paper argues that requirements are met now toset up the first level discipline of accounting professional(or class),and the three secondary discipline(or major):the accounting,financialmanagement,auditing,should be included into accounting first level discipline(or classes).Then,accounting will become first level disciplineparalleling with business administration first level.
基金Supported by Traditional Chinese medicine foundation of Zhejiang province:Clinical Study on the Correlation Between Tourette Syndrome and Anatomical Changes in the Atlantoaxial Joint(2010ZB162)Medical Health Science and Technology Project of Zhejiang Provincial Health Commission:Study on Protein Fingerprinting of Tourette Syndrome(2011KYB142)+1 种基金Renowned Traditional Chinese Medicine Expert Inheritance Studio Construction Project of Zhejiang province(No.GZS2020049)Key Disciplines of Traditional Chinese Medicine Foundation of Zhejiang Province(2012-XK-D20)。
文摘OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 into three groups:group A(acupuncture combined with atlantoaxial joint bone setting therapy group),group B(acupuncture group),and group C(tiapride group).After two months of treatment,the Yale global tic severity scale(YGTSS)score reduction,improvement in social function impairment,clinical efficacy,and long-term efficacy in the three groups were compared.RESULTS:After treatment,in the analysis of YGTSS score reduction,social function impairment improvement,the clinical control rate,and long-term efficacy,the results were all Group A>Group B>Group C,with a statistically significant difference(P<0.05).However,the total clinical efficacy of treatment in group A(94.9%)was not significantly different from that in group B(91.8%).Adverse reactions did not occur in groups A and B,and several adverse reactions occurred in 29%(n=58)of the group C patients.CONCLUSION:Compared with traditional drug therapy,acupuncture combined with atlantoaxial joint bone setting therapy has better clinical and long-term efficacy.This treatment strategy can improve the social function of children and prevent adverse reactions to drugs.
基金This retrospective analysis incorporated data from two clinical trials(CTR20220854 and CTR20222843)sponsored by Chongqing Chenan Biopharmaceutical Co.,Ltd.and Jiangsu Hengrui Pharmaceuticals Co.,Ltd.However,these sponsors did not partake in the study design,data interpretation,or manuscript preparation.
文摘BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques before entry into the market.Typically,blood glucose(BG)levels are maintained at 5%below baseline to suppress endogenous insulin secretion in healthy volunteers.However,in scenarios where BG baseline is relatively low,maintaining it at 5%below baseline can increase hypoglycemic risk.Consequently,we adjusted to maintain it at 2.5%below a baseline of<4.00 mmol/L.It remains uncertain whether this adjustment impacts endogenous insulin inhibition or the PD of study insulin.AIM To evaluate and compare the PD and C-peptide status using two different target BG setting methods.METHODS Data came from euglycemic clamp trials assessing the PK/PD of insulin aspart(IAsp)in healthy participants.Target BG was set at 2.5%below baseline for those with a basal BG of<4.00 mmol/L(group A),and at 5%below baseline for others(group B).The area under the curve(AUC)of IAsp(AUC_(IAsp,0-8 h))and GIR from 0 to 8 hours(AUCGIR,0-8 h)was used to characterize the PK and PD of IAsp,respectively.The C-peptide reduction and PK/PD of IAsp were compared between the two groups.RESULTS Out of 135 subjects,15 were assigned to group A and 120 to group B;however,group B exhibited higher basal Cpeptide(1.59±0.36 vs 1.32±0.42 ng/mL,P=0.006).Following propensity score matching to adjust for basal Cpeptide differences,71 subjects(15 in group A and 56 in group B)were analyzed.No significant differences were observed in demographics,IAsp dosage,or clamp quality.Group B showed significantly higher baseline(4.35±0.21 vs 3.91±0.09 mmol/L,P<0.001),target(4.13±0.20 vs 3.81±0.08 mmol/L,P<0.001),and clamped(4.10±0.17 vs 3.80±0.06 mmol/L,P<0.001)BG levels.Both groups exhibited comparable C-peptide suppression(32.5%±10.0%vs 35.6%±12.1%,P=0.370)and similar IAsp activity(AUCGIR,0-8 h:1433±400 vs 1440±397 mg/kg,P=0.952)under nearly equivalent IAsp exposure(AUC_(IAsp,0-8 h):566±51 vs 571±85 ng/mL×h,P=0.840).CONCLUSION Maintaining BG at 2.5%below a baseline of<4.00 mmol/L did not compromise the endogenous insulin suppression nor alter the observed pharmacodynamic effects of the study insulin.
文摘Breast cancer is the leading cause of cancer-related mortality in women globally,with its incidence continuing to rise,particularly in low-and middle-income countries,presenting a significant public health challenge worldwide[1].According to data from the Institute for Health Metrics and Evaluation(IHME)and the World Health Organization(WHO),the gap in access to healthcare services between high-and low-income countries contributes to delayed detection,increased incidence of advanced-stage disease,and,consequently,higher mortality rates(up to 50%higher compared to high-income countries)[1,2].This translates into inequalities in access to screening and early diagnosis methods,which exacerbate the burden of this disease in low-resource settings where infrastructure,funding,and access to trained professionals are limited[3].
基金financially supported by the National Natural Science Foundation of China (32071978)the National Key Research and Development Program of China (2022YFD2300901 and 2022YFD2300905)。
文摘High temperature stress (HT) significantly reduces maize yield by impairing starch accumulation in kernels.However,the mechanism by which HT affects starch synthesis remains controversial-whether through reduced assimilate supply or direct inhibition on kernel metabolism.To clarify these mechanisms,a heat-sensitive maize hybrid,Xianyu 335 (XY),was exposed to 30℃/20℃ (maximum/minimum temperature,control) and 40℃/30℃ for seven consecutive days during the seed setting stage.Synchronous pollination (SP),apical pollination (AP),and shading treatments were applied to manipulate the inherent source–sink ratio in maize plants.Results showed that apical kernel weight decreased by 11.9%under 40℃ in the SP treatment.The ^(13)C content,starch accumulation,and cell-wall invertase (CWIN) activity also declined by 15.9,36.7,and 16.4%,respectively,under HT.In the shading treatment,40℃/30℃ caused even greater reductions in^(13)C content,starch accumulation,and CWIN activity due to diminished assimilate supply.Conversely,in the AP treatment,starch content and CWIN activity increased by 22.0 and 18.5%,respectively,under 40℃/30℃,resulting in kernel weight and ^(13)C content similar to those in SP and shading treatments regardless of temperature.Consistent with apical kernels under AP,HT did not negatively affect middle kernels in either SP or shading treatments,as kernel weight and starch content remained unchanged under HT.Although all kernels were exposed to the same HT or control environment,their responses varied a lot.The impaired starch synthesis in apical kernels under HT was rescued by increasing carbon supply via AP treatment.The contrasting performance among middle kernels,apical kernels under AP,and apical kernels under SP or shading indicates that reduced carbon supply is a critical factor underlying inhibited starch accumulation.Our findings provide a theoretical basis for further understanding kernel abortion under HT.
基金supported by the National Natural Science Foundation of China(42372250,42102262 and 41972235)National Key Research and Development Program Project(2023YFF0803701)+1 种基金Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(SML2023SP206)the program of China Scholarship Council。
文摘The Shenshan Group provides important geological information which is vital in unraveling the amalgamation and subsequent rifting processes of South China.While conventional studies have asserted its formation in a subduction setting,the distinct investigation reveals the necessity for reassessment.To address this,the authors employ integrated methods encompassing petrological,zircon U-Pb geochronological,Lu-Hf isotopic and geochemical methods for sedimentary rocks from the upper Shenshan subgroup and Banxi Group.The geochemical results indicate that they were formed through the recycling deposition of intermediate-acidic igneous source material and experienced moderate chemical weathering.Additionally,both sedimentary sequences exhibit characteristics consistent with those formed in an intracontinental extensional rift setting since ca.810 Ma.The provenance analysis indicates that the upper Shenshan subgroup primarily originates from the Yangtze Domain,while the Banxi Group from both the Yangtze and Cathaysia domains.Synthesizing with previous studies,the Shenshan Group should be subdivided into the lower and upper subgroups which represent distinct tectonic backgrounds.The lower subgroup is inferred to have formed in an Early Neoproterozoic fore-arc setting,akin to the Zhoutan group.The upper subgroup corresponds to the Banxi Group,representing the Middle Neoproterozoic postorogenic rift setting,responding to the breakup of Rodinia.
基金funded by the Research Project:THTETN.05/24-25,VietnamAcademy of Science and Technology.
文摘Satellite image segmentation plays a crucial role in remote sensing,supporting applications such as environmental monitoring,land use analysis,and disaster management.However,traditional segmentation methods often rely on large amounts of labeled data,which are costly and time-consuming to obtain,especially in largescale or dynamic environments.To address this challenge,we propose the Semi-Supervised Multi-View Picture Fuzzy Clustering(SS-MPFC)algorithm,which improves segmentation accuracy and robustness,particularly in complex and uncertain remote sensing scenarios.SS-MPFC unifies three paradigms:semi-supervised learning,multi-view clustering,and picture fuzzy set theory.This integration allows the model to effectively utilize a small number of labeled samples,fuse complementary information from multiple data views,and handle the ambiguity and uncertainty inherent in satellite imagery.We design a novel objective function that jointly incorporates picture fuzzy membership functions across multiple views of the data,and embeds pairwise semi-supervised constraints(must-link and cannot-link)directly into the clustering process to enhance segmentation accuracy.Experiments conducted on several benchmark satellite datasets demonstrate that SS-MPFC significantly outperforms existing state-of-the-art methods in segmentation accuracy,noise robustness,and semantic interpretability.On the Augsburg dataset,SS-MPFC achieves a Purity of 0.8158 and an Accuracy of 0.6860,highlighting its outstanding robustness and efficiency.These results demonstrate that SSMPFC offers a scalable and effective solution for real-world satellite-based monitoring systems,particularly in scenarios where rapid annotation is infeasible,such as wildfire tracking,agricultural monitoring,and dynamic urban mapping.
文摘Using a modified numerical model with higher resolution both horizontal and vertical directions,the surface fluxes of the sensible and latent heat in the HEIFE(Heihe Field Experiment)region were diagnosed.Based on statistical analy- sis for the diagnostic fluxes,the representativeness and location of observational stations in the HEIFE region were inves- tigated,a concrete scheme for setting up the observational stations in the HEIFE region with different underlying sur- faces are obtained and the general principle of choosing the locations of observational stations with better representativeness is proposed.
文摘When being planted in wide areas in southern China (23°23' - 33°23' N, 98°35' - 120°19' E, sea level above 2.7 - 1285 m), Liangyoupeijiu (LYPJ), a two-line hybrid rice combination, showed a seed setting rate of 75.2 - 77.2%, which was lower by 4.3 - 7.5 percent point than that of an indica hybrid rice Shanyou 63 (CK), with similar values of grain yield and coefficients of variation to CK. Sowing during 5-25th of May in Nanjing (32°3' N, 118°48' E), China, LYPJ headed before 4th September, and gave a seed setting rate of 75 - 90%, and grain yield over 1 kg/m2. If the sowing date was delayed to 14 - 15th, June, its heading date would be as late as 17th - 21st September, and seed setting rate would be declined by 10 - 15% in comparison with that on a suitable sowing date. When flowering took place at an average daily temperature range of 13.7 - 28.5℃ for five days, the spikelet fertility (SF) would be increased by 1.9- 10.7%, for each increment of 1℃. The suitable (SF≥90%) and safe (SF≥75%) temperatures for flowering stage were indicated to be 26.5℃ and 22.9℃, respectively. To get a high and stable seed set in cultivating LYPJ, it was recommended that LYPJ would be planted in the areas south of 34癗, and the favorable average daily temperature during flowering stage should be at 26 - 28℃.
文摘The central Fujian Province, situated on the juncture of paleo-uplift of Wuyishan, Yongmei Late Paleozoic depression and the eastern volcanic rift-faulting zone, is mainly composed of the outcropped metamorphic basements in the Middle-Late and Early Proterozoic, which constitute two upper and lower giant thick formations of Precambrian volcanic-sedimentary cycles, respectively. The formation of Dongyan Group is an important Middle-Upper Proterozoic component, and the Dongyan Group is directly related to massive sulfide deposit in this area. In recent years, plenty of lead, zinc, copper, silver and gold deposits have been found and explored. The Precambrian paleorift setting of the central Fujian Province served as a favorite metallogenic background for the formation of large- and superlarge-scale volcanic massive sulfide (VMS) lead and zinc polymetal deposits. The Dongyan Group consists chiefly of a set of ancient volcanic sedimentary formations that are composed mainly of greenschist. Its major lithologic types comprise greenschist, marble, quartzite and granofels class including various components. The metamorphic rocks of Dongyan Group are the main composition of Middle and Upper Proterozoic volcanic-sedimentary cycle. The original rock of Dongyan Group, a stable rock association, is volcanic sedimentation and normal marine sedimentation. But the original volcanic rocks, basic and acid, are bimodal. The volcanic rocks were formed in the extensional continental rift setting.
文摘Distributed generators now is widely used in electrical power networks, in some cases it works seasonally, and some types works at special weather conditions like photo voltaic systems and wind energy, and due to this continuous changes in generation condition, the fault current level in network will be affected, this changes in fault current level will affect in the coordination between protection relays and to keep the coordination at right way, an adaptive protection system is required that can adaptive its setting according to generation changes, the fault current level in each case is evaluated using ETAP software, and the required relay setting in each case is also evaluated using Grey Wolf Optimizer (GWO) algorithm, and to select suitable setting which required in each condition, to select the active setting group of protection relay according to generation capacity, central protection unite can be used, and to improve protection stability and minimizing relays tripping time, a proposed method for selecting suitable backup relay is used, which leads to decrease relays tripping time and increase system stability, output settings for relays in all cases achieved our constrains.
基金funded by the Chinese Geological Survey Program(Grant Nos.DD20160035,DD20190047)the National Nonprofit Institute Research Grant of IGGE(AS2022P03)the Chinese Scholarship Council(File No.201606400032)Scholarship to Liu Yuheng。
文摘The Mesoproterozoic Baoban Group is the oldest basement in Hainan Island and has played an important role in Columbia(Nuna)supercontinent reconstructions.The Mesoproterozoic granitic intrusions in the Baoban Group are the most widely-exposed Precambrian magmatic rocks and are the key to understanding the tectonic settings of Hainan Island and its relationship with the South China Block and the Columbia supercontinent.New LA-ICP-MS zircon U-Pb dating on three mylonitic granite samples from the Tuwaishan and Baoban areas yield ages ranging from 1447 Ma to 1437 Ma,representing the absolute timing of the emplacement of the granitic intrusions.Combined with previously published geochronological data for rocks from the Baoban Group and regional mafic intrusions,it is concluded that the Baoban Group formed at 1460-1430 Ma,coeval with the emplacement of the granitic and mafic intrusions.New in-situ zircon LuHf isotope analyses for the three mylonitic granite samples yielded positiveε(t)values,ranging from+0.49 to+8.27,with model ages(T~C)ranging from 2181 Ma to 1687 Ma,suggesting that the granitic intrusions originated from a mixed source of Paleoproterozoic crust with juvenile crust.New zircon trace element data show characteristics of high Th/U values of 0.24-1.50,steep slopes from LREE to HREE and negative Pr,Eu anomalies with positive Ce,Sm anomalies,representing typical magmatic zircons formed in continental crust.Compared with available magmatic and detrital zircon ages from Precambrian rocks in the Cathaysia Block,Yangtze Block and western Laurentia,it is inferred that Hainan Island was separated from both the Cathaysia Block and the Yangtze Block,instead being connected with western Laurentia in the Columbia supercontinent.Considering the decreasing tendency of basin deposition time along the western margin of Laurentia,it is proposed that Hainan Island was located to the north or northwest of the Belt-Purcell Supergroup,along the western margin of Laurentia,during the breakup of the Columbia supercontinent.
基金Supported by the Shandong Provincial Natural Science Foundation,China(No.ZR2018BD026)the National Marine Geology Special Project(No.DD20190377)。
文摘To reconstruct the paleoenvironment,the petrography and geochemical compositions of the upper Permian Dalong Formation(Fm)(P_(3)d)sandstones in the Central Uplift,South Yellow Sea Basin,was investigated,after which the provenance,tectonic setting,weathering conditions,and diagenetic history were determined.The Dalong Fm is mainly composed of sandstones with a few mudstones and limestones.The petrographic analysis showed that the P_(3)d sandstones are in low maturity and could be classified into feldspar sandstone and lithic sandstone on average framework composition of Q_(63)F_(16)L_(21).The major and trace element results show that Dalong Fm sandstones are enriched in Rb and depleted in Cr and Ni compared with the upper continental crust(UCC).The chemical weathering intensity is weak to low moderate in the source area as indicated by the chemical index of alteration(CIA)and other results from a variety of methods.The diagenetic process included three main stages:eodiagenesis,mesodiagenesis,and telodiagenesis.Tectonic discrimination plots show that the source areas were an active continental margin(ACM)and a passive continental margin(PCM),which may have been related to the northward movement of the Lower Yangtze Plate(LYP)and the collision between the LYP and the North China Plate(NCP).
文摘Research studies conducted in the healthcare sector usually examine patients’ and workers’ wellbeing as separate entities;however, recent studies have revealed significant correlations between, for example, patient satisfaction, workers stress and burnout. The present study examines the relationships between patient perceived quality of care (in terms of satisfaction with regard to accessibility, organizational efficiency and humaneness of care), and workers’ perceived quality of organizational life (in term of organizational support and availability of resource and reward), quality of relationship in the work-unit (superior and coworkers), quality of relationship with patients (disproportionate client expectations and customer verbal aggression) and individual health (emotional exhaustion and depersonalization, job satisfaction). 147 workers and 132 patients from seven hospital wards in northern Italy constitute the data base for the study. Analyses showed that accessibility and humaneness of care were negatively associated with disproportionate patient expectations, patient verbal aggression, emotional exhaustion and positively associated with availability of material recourses. Moreover, accessibility was also positively associated with the organizational support while organizational efficiency with support from colleagues. Globally, the results of the present study confirm that staff wellbeing is an essential aspect in relation to the patient perception of the quality of care and supporting the assumption that healthy organizations improve the wellbeing of their workers, their organizational performance and the quality of their service at the same time.
文摘Africa faces significant challenges in terms of material and personnel resources for oncology interventions. This is particularly evident in South Africa, where resources are divided into high- and low-resource settings. High-resource settings cater to those with financial means to access private oncology facilities. However, many breast cancer patients receive care in South Africa’s low-resource settings, such as public hospital oncology clinics. Unfortunately, these settings have limited service providers and fail to offer comprehensive interventions, resulting in poor outcomes. However, recent research has highlighted the significance of socially supportive relationships in promoting healing and overall individual well-being, and spirituality has been identified as a source of positive outcomes in cancer patients. This systematic review paper explores the feasibility of implementing support group cancer care and interventions that incorporate social support networks available in community settings, and spiritual practices facilitated by traditional healers, and religious/spiritual leaders. These interventions can be provided within low-resource settings to women diagnosed with breast cancer. Inclusive participation of spouses, children, and extended family in the support group cancer care can facilitate healing for the entire system. Focusing on the strengths and resources within communities and incorporating these complementary services, can enhance the well-being and quality of life for Black African women diagnosed with breast cancer, despite low-resource settings. This approach acknowledges the potential of community-based support networks and encourages collaboration between various stakeholders, including community health educators, nurses, lay counselors, and community volunteers, to address the complex needs of these patients.
