Chinese Premier Li Keqiang delivered a comprehensive,balanced,and forwardlooking work report at the opening of the Fifth Session of China’s 12th National People’s Congress(NPC).From a global perspective,China’s rol...Chinese Premier Li Keqiang delivered a comprehensive,balanced,and forwardlooking work report at the opening of the Fifth Session of China’s 12th National People’s Congress(NPC).From a global perspective,China’s role in the international community is rising.The nation accounts for a third of global economic growth and plays an increasingly展开更多
Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)tria...Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)triangle in the southwestern margin of the Yangtze Block is a globally recognized carbonate-hosted Pb-Zn metallogenic province and also an essential part of the South China low-temperature metallogenic domain.This region has>30 million tons(Mt)Zn and Pb resources and shows the enrichment of dispersed metals,such as Ga,Ge,Cd,Se,and Tl.During the past 2 decades,abundant data on mineralization ages of Pb-Zn deposits within the SYG triangle have been documented based on various radioisotopic dating methods,resulting in significant progress in understanding the geodynamic background and ore formation of Pb-Zn deposits hosted in sedimentary rocks at SYG triangle.This paper provides a comprehensive summary of the geochronological results and Pb-Sr isotopic data regarding Pb-Zn deposits in the SYG triangle,which identified two distinct Pb-Zn mineralization periods influencing the dynamic processes associated with the expansion and closure of the Paleo-Tethys Ocean in the western margin of the Yangtze Block.The predominant phase of Pb-Zn mineralization at SYG triangle spanned from the Middle Triassic to Early Jurassic(226-191 Ma),which was intensely correlated with the large-scale basin fluid transport triggered by the closure of the Paleo-Tethys Ocean and Indosinian orogeny.The secondary Pb-Zn mineralization phase occurred during the Late Devonian to Late Carboniferous and was controlled by extensional structures associated with the expansion of the Paleo-Tethys Ocean.Further investigation is necessary to clarify the occurrence and potential factors involved in the Pb-Zn mineralization events during the Late Devonian to Late Carboniferous.展开更多
The Longshan orogenic belt is located in the southwestern margin of Ordos Basin at the junction zone between the Western Qinling and Northern Qilian orogenic belt.Voluminous Early Paleozoic magmatism in this area is o...The Longshan orogenic belt is located in the southwestern margin of Ordos Basin at the junction zone between the Western Qinling and Northern Qilian orogenic belt.Voluminous Early Paleozoic magmatism in this area is of key significance for determining the Early Paleozoic tectonic evolution and deep crust-mantle structure.Previous studies mainly focused on the Paleozoic granites;the coeval mafic rocks in this area are still poorly understood.A set of Late Silurian intraplate tholeiitic basalts has been discovered in Longshan area,providing key evidence for the mantle source and deep geodynamic background in this area.The Late Silurian Angou basalt has similar geochemical features as intraplate tholeiitic basalt,with high Na_(2)O/K_(2)O ratios(5.22-8.25),enriched in large ion lithophile elements and LREE.In combination with their relatively evolved Sr-Nd isotopic composition[^(87)Sr/^(86)Sr(i)=0.7128-0.7140;ε_(Nd)(t)=-5.55 to-3.40],it is suggested that it originated from decompression melting of metasomatized enriched mantle in extensional setting.These results indicate that the mantle source in the junction zone of the West Qinling-North Qilian orogenic belt evolved from depleted to enriched with the continuation of Proto-Tethys subduction from the Cambrian to the Silurian.These results are of great significance to understanding the genesis of contemporaneous granite and the crust-mantle interaction in the junction zone between the Western Qinling and Northern Qilian orogenic belt.展开更多
Introduction: Hypertension, a non-communicable disease, is a major public health threat worldwide, accounting for a high level of morbidity and mortality. Although it has been extensively published among the general p...Introduction: Hypertension, a non-communicable disease, is a major public health threat worldwide, accounting for a high level of morbidity and mortality. Although it has been extensively published among the general population, further research is needed to understand the reality of hypertension within the custodial setting. This study aimed to investigate the factors associated with arterial hypertension in custodial settings in southern Benin in 2023. Methods: This was a cross-sectional, descriptive, analytical study held in prisons in southern Benin from March to April 2023, involving inmates selected by two-stage random sampling. In the first stage, four prisons out of the six in the southern region of Benin were selected by simple random sampling. In the second stage, the prisoners were selected by systematic random sampling, with the sampling frame being the numbered list of eligible prisoners in each prison selected. Data collected by observation and questionnaire survey were analyzed using Stata 11 software. Hypertension was defined as systolic blood pressure ≥ 140 mmHg and diastolic blood pressure ≥ 90 mmHg. Overweight was defined by a body mass index (weight/height<sup>2</sup> (kg/m<sup>2</sup>) ≥ 25. Factors associated with hypertension were identified by multiple logistic regression, at a 5% threshold of significance. Results: Altogether 336 inmates aged 37.55 ± 1.72 years were surveyed. The prevalence of hypertension in custodial settings in southern Benin in 2023 was 31.32% (95% CI [17.06;52.57]). Associated factors were inmate age (ORa = 3.36 95% CI: [1.94;5.85]) and abnormal waist circumference (ORa = 2.61 95% CI [1.27;5.40]). Conclusion: The prevalence of arterial hypertension in prisons of southern Benin (31.32%) is high when compared with the national average (25.9% (22.5-29.3)). The ministries of the Interior and Health need to collaborate to involve inmates in preventive strategies for non-communicable diseases, including hypertension.展开更多
Introduction: Standard procedures for surgical fixation of proximal femoral fractures (PFF) require an image intensifier which in developing countries remains a luxury. We hypothesized that, with a well-codified techn...Introduction: Standard procedures for surgical fixation of proximal femoral fractures (PFF) require an image intensifier which in developing countries remains a luxury. We hypothesized that, with a well-codified technique, the Watson Jones approach (WJA) without image intensifier nor traction table, can allow open reduction and internal fixation (ORIF) of PFF using Dynamic hip screw (DHS), with satisfactory outcome. Patients and methods: Forty one consecutive patients (mean age 59.5 ± 21.6 years, 61% males) who were followed in a Teaching Hospital for PFF treated by ORIF using the WJA and DHS from January 2016 to December 2020 were reassessed. The outcome measures were the quality of the reduction, the positioning of the implants, the tip-apex distance (TAD), the rate and delay of consolidation, the functional results using Postel Merle d’Aubigné (PMA) score, the rate of surgical site infection (SSI) and the overall mortality. Logistic regression was used to determine factors associated with mechanical failure. Results: The mean follow-up period was 33.8 ± 15.0 months. Fracture reduction was good in 31 (75.6%) cases and acceptable in 8(19.5%) cases. Implant position was fair to good in 37 (90.2%) patients. The mean TAD was 26.1 ± 3.9 mm. Three patients developed SSI. Consolidation was achieved in 38 (92.6%) patients. The functional results were good to excellent in 80.5% of patients. The overall mortality rate was 7.3%. There were an association between mechanical failure and osteoporosis (p = 0.04), fracture reduction (p = 0.003), and TAD (p = 0.025). In multivariate logistic regression, no independent factors were predictive of mechanical failure. Conclusion: This study shows that ORIF using DHS for PFF via the Watson-Jones approach without an image intensifier can give satisfactory anatomical and functional outcomes in low-resource settings. It provides and validates a reliable and reproducible technique that deserves to be diffused to surgeons in austere areas over the world.展开更多
This study identified castor oil and phosphate ester as effective retarders through setting time,tensile,and flexural tests,and determined their optimal dosages.The mechanism by which phosphate ester affects the setti...This study identified castor oil and phosphate ester as effective retarders through setting time,tensile,and flexural tests,and determined their optimal dosages.The mechanism by which phosphate ester affects the setting time of polyurethane was further investigated using molecular dynamics simulations.Fourier transform infrared spectroscopy was also employed to systematically study the physical and chemical interactions between phosphate esters and polyurethane materials.The results demonstrate that a 1%concentration of phosphate ester provides the most effective retarding effect with minimal impact on the strength of polyurethane.When phosphate ester is added to the B component of the two-component polyurethane system,its interaction energy with component A decreases,as do the diffusion coefficient and aggregation degree of component B on the surface of component A.This reduction in interaction slows the setting time.Additionally,the addition of phosphate ester to polyurethane leads to the disappearance or weakening of functional groups,indicating competitive interactions within the phosphate ester components that inhibit the reaction rate.展开更多
Background:Nuclear receptor-binding SET domain 2(NSD2)is a histone methyltrans-ferase,that catalyzes dimethylation of lysine 36 of histone 3(H3K36me2)and is asso-ciated with active transcription of a series of genes.N...Background:Nuclear receptor-binding SET domain 2(NSD2)is a histone methyltrans-ferase,that catalyzes dimethylation of lysine 36 of histone 3(H3K36me2)and is asso-ciated with active transcription of a series of genes.NSD2 is overexpressed in multiple types of solid human tumors and has been proven to be related to unfavorable prog-nosis in several types of tumors.Methods:We established a mouse model in which the NSD2 gene was conditionally knocked out in intestinal epithelial cells.We used azoxymethane and dextran sodium sulfate to chemically induce murine colorectal cancer.The development of colorectal tumors were investigated using post-necropsy quantification,immunohistochemistry,and enzyme-linked immunosorbent assay(ELISA).Results:Compared with wild-type(WT)control mice,NSD2^(fl/fl)-Vil1-Cre mice exhib-ited significantly decreased tumor numbers,histopathological changes,and cytokine expression in colorectal tumors.Conclusions:Conditional knockout of NSD2 in intestinal epithelial cells significantly inhibits colorectal cancer progression.展开更多
The dramatic rise in the number of people living in cities has made many environmental and social problems worse.The search for a productive method for disposing of solid waste is the most notable of these problems.Ma...The dramatic rise in the number of people living in cities has made many environmental and social problems worse.The search for a productive method for disposing of solid waste is the most notable of these problems.Many scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated ambiguity.The goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site selection.The characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these uncertainties.To tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s method.Following this,an intelligent algorithm is suggested.The steps of the suggested algorithm are explained with an example that explains itself.The compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their viability.This study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,respectively.It uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior literature.It is simpler for the decisionmakers to look at each option separately because the decision is uncertain.Comparing the computed results,it is discovered that they are consistent and dependable because of their preferred properties.展开更多
The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolc...The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolcanic rocks in the Belts that make up the Birimian Supergroup were intruded by granitoids during the Eburnean Orogeny.This research aims to classify granitoids in the Edikan Mine and ascertain the petrogenetic and geochemical characteristics of some auriferous granitoids in the wider Kumasi Basin,Ghana,to understand the implications for geodynamic settings.A multi-methods approach involving field studies,petrographic studies,and whole-rock geochemical analysis was used to achieve the goal of the study.Petrographic studies revealed a relatively high abundance of plagioclase and a low percentage of K-feldspars(anorthoclase and orthoclase)in the Fobinso samples,suggesting that the samples are granodioritic in nature,while the Esuajah samples showed relatively low plagioclase abundance and a high percentage in K-feldspars,indicating that they are granitic.The granitoids from the study areas are co-magmatic.The granitoids in Esuajah and Fobinso are generally enriched in large ion lithophile elements and light rare earth elements than high field strength elements,middle rare earth elements,and heavy rare earth elements,indicating mixing with crustal sources during the evolution of the granitoids.The granitoids were tectonically formed in a syn-collisional+VAG setting,which implies that they were formed in the subduction zone setting.Fobinso granodiorites showed S-type signatures with evidence of extensive crustal contamination,while the Esuajah granites showed I-type signatures with little or no crustal contamination and are peraluminous.Gold mineralization in the study area is structurally and lithologically controlled with shear zones,faulting,and veining as the principal structures controlling the mineralization.The late-stage vein,V3,in the Edikan Mine is characterized by a low vein angle and is mineralized.展开更多
Vertical position changes of ground-based Global Navigation Satellite System(GNSS) stations have been used to study regional terrestrial water storage(TWS) changes. However, the feasibility is still unclear in many ar...Vertical position changes of ground-based Global Navigation Satellite System(GNSS) stations have been used to study regional terrestrial water storage(TWS) changes. However, the feasibility is still unclear in many areas due to diverse local effects. This study aims to evaluate the capability of GNSS vertical displacements in monitoring hydrological variations in four climate settings over Chinese mainland. The spatial and temporal variations of hydrological load-induced(HYDL) vertical displacements at 208 GNSS sites during 2011-2020 were analyzed by comparing with Gravity Recovery and Climate Experiment(GRACE)/GRACE Follow-On(GFO) and Global Land Data Assimilation System(GLDAS) derived TWS changes. The results indicate that GNSS vertical positions show different capabilities in capturing seasonal and non-seasonal hydrological dynamics in different climate regions. Among the four climatic settings, the subtropical monsoon climate(SMC) region, with the largest deformation fluctuation(the regional mean root mean square(RMS) is 7.97 mm), has the highest regional mean HYDL-GRACE and HYDL-GLDAS anti-correlation coefficients(CCs) of-0.47 and-0.45 at the seasonal scale, respectively. For the individual GNSS site, the number of the sites with CC <-0.40 between HYDL and GRACE/GLDASderived TWS changes accounts for 55.1% and 55.1%(SMC), 13.0% and 7.4%(temperate monsoon climate, TMC), 6.7% and 13.3%(temperate continental climate, TCC), 32.3% and 38.7%(plateau climate,PC), respectively. For the non-seasonal term, although the proportion with CC <-0.40 in each climate type decreases mainly due to the influence of local geodynamic and human activities, especially in the SMC and PC regions, GNSS site vertical deformations still show good capability in monitoring hydrological extremes. The results provide valuable information for better application of GNSS to hydrology.展开更多
BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques...BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques before entry into the market.Typically,blood glucose(BG)levels are maintained at 5%below baseline to suppress endogenous insulin secretion in healthy volunteers.However,in scenarios where BG baseline is relatively low,maintaining it at 5%below baseline can increase hypoglycemic risk.Consequently,we adjusted to maintain it at 2.5%below a baseline of<4.00 mmol/L.It remains uncertain whether this adjustment impacts endogenous insulin inhibition or the PD of study insulin.AIM To evaluate and compare the PD and C-peptide status using two different target BG setting methods.METHODS Data came from euglycemic clamp trials assessing the PK/PD of insulin aspart(IAsp)in healthy participants.Target BG was set at 2.5%below baseline for those with a basal BG of<4.00 mmol/L(group A),and at 5%below baseline for others(group B).The area under the curve(AUC)of IAsp(AUC_(IAsp,0-8 h))and GIR from 0 to 8 hours(AUCGIR,0-8 h)was used to characterize the PK and PD of IAsp,respectively.The C-peptide reduction and PK/PD of IAsp were compared between the two groups.RESULTS Out of 135 subjects,15 were assigned to group A and 120 to group B;however,group B exhibited higher basal Cpeptide(1.59±0.36 vs 1.32±0.42 ng/mL,P=0.006).Following propensity score matching to adjust for basal Cpeptide differences,71 subjects(15 in group A and 56 in group B)were analyzed.No significant differences were observed in demographics,IAsp dosage,or clamp quality.Group B showed significantly higher baseline(4.35±0.21 vs 3.91±0.09 mmol/L,P<0.001),target(4.13±0.20 vs 3.81±0.08 mmol/L,P<0.001),and clamped(4.10±0.17 vs 3.80±0.06 mmol/L,P<0.001)BG levels.Both groups exhibited comparable C-peptide suppression(32.5%±10.0%vs 35.6%±12.1%,P=0.370)and similar IAsp activity(AUCGIR,0-8 h:1433±400 vs 1440±397 mg/kg,P=0.952)under nearly equivalent IAsp exposure(AUC_(IAsp,0-8 h):566±51 vs 571±85 ng/mL×h,P=0.840).CONCLUSION Maintaining BG at 2.5%below a baseline of<4.00 mmol/L did not compromise the endogenous insulin suppression nor alter the observed pharmacodynamic effects of the study insulin.展开更多
OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 i...OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 into three groups:group A(acupuncture combined with atlantoaxial joint bone setting therapy group),group B(acupuncture group),and group C(tiapride group).After two months of treatment,the Yale global tic severity scale(YGTSS)score reduction,improvement in social function impairment,clinical efficacy,and long-term efficacy in the three groups were compared.RESULTS:After treatment,in the analysis of YGTSS score reduction,social function impairment improvement,the clinical control rate,and long-term efficacy,the results were all Group A>Group B>Group C,with a statistically significant difference(P<0.05).However,the total clinical efficacy of treatment in group A(94.9%)was not significantly different from that in group B(91.8%).Adverse reactions did not occur in groups A and B,and several adverse reactions occurred in 29%(n=58)of the group C patients.CONCLUSION:Compared with traditional drug therapy,acupuncture combined with atlantoaxial joint bone setting therapy has better clinical and long-term efficacy.This treatment strategy can improve the social function of children and prevent adverse reactions to drugs.展开更多
The Paleoproterozoic basement of Zoukougbeu in central-western Côte d’Ivoire lies within the southern Baoulé-Mossi domain of the West African Craton,a key area for understanding the crustal evolution associ...The Paleoproterozoic basement of Zoukougbeu in central-western Côte d’Ivoire lies within the southern Baoulé-Mossi domain of the West African Craton,a key area for understanding the crustal evolution associated with the Eburnean orogeny.However,the petrogenesis and geodynamic context of the granitoid intrusions in this region remain poorly constrained,despite their potential sig nificance for regional crustal growth and mineralization.This study integrates petrographic and whole-rock geochemical data from drill-core samples to clar-ify the origin and tectonic evolution of these rocks.The lithological assemblage includes granodiorite,granite,diorite,gneiss,and pegmatite,variably deformed and hydrothermally altered.Petrographic analysis reveals plagioclase-quartzbiotiteamphibole assemblages overprinted by chlorite-epidote alteration,in-dicating greenschist-to amphibolite-facies metamorphism.Geochemically,the rocks define a calc-alkaline,metaluminous to slightly peraluminous suite with tonalite-trondhjemite-granodiorite(TTG)affinity.Their enrichment in largeion lithophile elements and depletion in Nb-Ta-Ti,coupled with LREE enrich-ment and negative Eu anomalies,are typical of subduction-related magmatism.These signatures indicate that the Zoukougbeu granitoids originated from par-tial melting of hydrated basaltic crust with minor mantle input in a continental volcanic-arc setting during the Eburnean orogeny(~2.1-2.0 Ga).This finding refines the current understanding of Paleoproterozoic crustal evolution in the southern West African Craton and highlights the role of arc magmatism in its stabilization.展开更多
Cardiac arrest is associated with high rates of mortality and significant long-term neurological disability in survivors.Timely and accurate assessment following successful resuscitation is critical for optimizing out...Cardiac arrest is associated with high rates of mortality and significant long-term neurological disability in survivors.Timely and accurate assessment following successful resuscitation is critical for optimizing outcomes.Imaging plays a central role in this evaluation process,providing crucial insights into the etiology of arrest,the extent of cerebral and cardiac injury,and guiding both acute management and long-term prognostication.A structured,multimodal imaging approach utilizing tools such as computed tomography,magnetic resonance imaging,echocardiography,and angiography is increasingly recognized as es-sential in the post-cardiac arrest setting.This review aims to consolidate current evidence related to the use of various imaging modalities across neurological,cardiac and systemic contexts.Particular emphasis is placed on the prognostic value and optimal timing of neuroimaging,the detection of potentially reversible causes of arrest,such as coronary occlusion or pulmonary embolism,and the emerging role of whole-body imaging in evaluating patients with non-traumatic out-of-hospital cardiac arrest.展开更多
The present study of metabasalts was carried out to understand the mantle source and geodynamic setting of the Mahakoshal Group in the Central Indian Tectonic Zone.In this study,we present detailed field,petrography,a...The present study of metabasalts was carried out to understand the mantle source and geodynamic setting of the Mahakoshal Group in the Central Indian Tectonic Zone.In this study,we present detailed field,petrography,and whole rock geochemistry of the Mahakoshal metabasalts.The Mahakoshal metabasalts are sub-alkaline in nature and belong to the tholeiitic series of rocks.The variation in rareearth element patterns of metabasalts indicates the different degrees of partial melting at shallow as well as deeper depths.Further,Eu/Eu*varies from 0.8 to 1.1(except sample KP-144=0.3),Ce/Ce*varies from 0.97 to 1.05,showing no cerium anomaly,and Nb/Nb*ranges from 0.7 to 1.3(except KP-144=0.1).The magnesium number(Mg#)varies from 0.2 to 0.3,which is quite low,indicating the evolved nature of the metabasalts.The studied metabasalts show E-MORB to OIB-type affinities,which are placed in the trench-distal back-arc setting.The opening of the Mahakoshal Basin is due to retreating orogen in the accretionary orogen setting and is contemporaneous with the assembly of the Columbia Supercontinent(~2.1-1.8 Ga).Hence,field,petrographic,and geochemical signatures indicate that the Mahakoshal basin opened as a back-arc rift basin on the Bundelkhand Craton,and that metabasalts are derived from the mantle that underwent variable degrees of partial melting at different depths.展开更多
Vibration cutting has emerged as a promising method for creating surface functional microstructures.However,achieving precise tool setting is a time-consuming process that significantly impacts process efficiency.This...Vibration cutting has emerged as a promising method for creating surface functional microstructures.However,achieving precise tool setting is a time-consuming process that significantly impacts process efficiency.This study proposes an intelligent approach for tool setting in vibration cutting using machine vision and hearing,divided into two steps.In the first step,machine vision is employed to achieve rough precision in tool setting within tens of micrometers.Subsequently,in the second step,machine hearing utilizes sound pickup to capture vibration audio signals,enabling fine tool adjustment within 1μm precision.The relationship between the spectral intensity of vibration audio and cutting depth is analyzed to establish criteria for tool–workpiece contact.Finally,the efficacy of this approach is validated on an ultra-precision platform,demonstrating that the automated tool-setting process takes no more than 74 s.The total cost of the vision and hearing sensors is less than$1500.展开更多
The implementation of Countermeasure Techniques(CTs)in the context of Network-On-Chip(NoC)based Multiprocessor System-On-Chip(MPSoC)routers against the Flooding Denial-of-Service Attack(F-DoSA)falls under Multi-Criter...The implementation of Countermeasure Techniques(CTs)in the context of Network-On-Chip(NoC)based Multiprocessor System-On-Chip(MPSoC)routers against the Flooding Denial-of-Service Attack(F-DoSA)falls under Multi-Criteria Decision-Making(MCDM)due to the three main concerns,called:traffic variations,multiple evaluation criteria-based traffic features,and prioritization NoC routers as an alternative.In this study,we propose a comprehensive evaluation of various NoC traffic features to identify the most efficient routers under the F-DoSA scenarios.Consequently,an MCDM approach is essential to address these emerging challenges.While the recent MCDM approach has some issues,such as uncertainty,this study utilizes Fuzzy-Weighted Zero-Inconsistency(FWZIC)to estimate the criteria weight values and Fuzzy Decision by Opinion Score Method(FDOSM)for ranking the routers with fuzzy Single-valued Neutrosophic under names(SvN-FWZIC and SvN-FDOSM)to overcome the ambiguity.The results obtained by using the SvN-FWZIC method indicate that the Max packet count has the highest importance among the evaluated criteria,with a weighted score of 0.1946.In contrast,the Hop count is identified as the least significant criterion,with a weighted score of 0.1090.The remaining criteria fall within a range of intermediate importance,with enqueue time scoring 0.1845,packet count decremented and traversal index scoring 0.1262,packet count incremented scoring 0.1124,and packet count index scoring 0.1472.In terms of ranking,SvN-FDOSM has two approaches:individual and group.Both the individual and group ranking processes show that(Router 4)is the most effective router,while(Router 3)is the lowest router under F-DoSA.The sensitivity analysis provides a high stability in ranking among all 10 scenarios.This approach offers essential feedback in making proper decisions in the design of countermeasure techniques in the domain of NoC-based MPSoC.展开更多
During the automated placement process of dry fibers,the positioning and fixation of dry fiber gauze belts are achieved by spraying setting agents.The amount of the setting agent is difficult to control when it is spr...During the automated placement process of dry fibers,the positioning and fixation of dry fiber gauze belts are achieved by spraying setting agents.The amount of the setting agent is difficult to control when it is sprayed manually.Furthermore,it can also affect the permeability of the preform,resin injection and the quality of the vacuum assisted resin infusion(VARI)molding,resulting in a decrease in the mechanical properties of composite materials.This study utilizes dry fiber automated placement equipment and an automated spraying system to manufacture preform structures,followed by VARI process to prepare composite samples with varying setting agent contents.Subsequently,mechanical characterization including interlaminar shear,bending and tensile testing is conducted to investigate the influence of setting agent content on both the manufacturing process and the mechanical properties of composite products.The results show that the interlaminar shear strength,bending strength and tensile strength of the sample gradually decrease with the increase of the content of the setting agent.The optimal setting agent content for automated laying of dry fiber is determined to be 4%-6%,balancing the preformed body’s layup quality and its impact on mechanical properties.Compared with agent-free samples,this range results in reductions of 3% in interlaminar shear strength,9% in bending strength,11% in bending modulus,and 13%-16% in tensile strength.展开更多
Clinical diagnosis for complex disease conditions is a complicated decision process involving systematic inference and differentiation.Artificial Intelligence(Al)models have been a widely established approach to help ...Clinical diagnosis for complex disease conditions is a complicated decision process involving systematic inference and differentiation.Artificial Intelligence(Al)models have been a widely established approach to help improve the efficiency of various kinds of clinical decision tasks(e.g.,diagnosis,treatment,and prognosis).However,due to the critical requirement of time efficiency,lack of sufficient information,and high probability of comorbid diseases in Outpatient and Emergency Settings(OES),it is still challenging to build clinically feasible Al models using the free text clinical records in OES for complex disease conditions,such as neurosurgery.Here we propose an Al diagnosis model,named LLM4DEU,for neurosurgery disease differentiations by fine-tuning a large language model(i.e.,ChatGLM)using the Department of Neurosurgery,the Beijing Tiantan Hospital OES electronic health records.LLM4DEU obtained state-of-the-art performance on clinical diagnosis with a F1 score of 78.53%,which is superior to five well-known baselines(including deep learning models).In addition,we evaluated the actual performance of the model by case studies on the diagnosis of specific neurosurgical diseases(e.g.,subdural hematoma,cerebral hemorrhage,and cerebral infarction).The experimental results show that the LLM4DEU model has significant advantages in diagnosing low-incidence disease conditions,and comparative analyses with clinical experts confirm the predictive power of the model in neurosurgical diagnosis.展开更多
Concentrated solar thermal power generation has been experimentally tested in advanced countries for a period of time.This paper demonstrates how this technology can be improved by using water molecules as a medium to...Concentrated solar thermal power generation has been experimentally tested in advanced countries for a period of time.This paper demonstrates how this technology can be improved by using water molecules as a medium to drive traditional generator sets for energy conversion,thereby simultaneously improving the energy conversion rate.Additionally,a novel contribution is made by incorporating a magic number 4 to enhance the focusing efficiency of Fresnel lenses,which drives improvements in power generation output and QE(Quantum Efficiency).展开更多
文摘Chinese Premier Li Keqiang delivered a comprehensive,balanced,and forwardlooking work report at the opening of the Fifth Session of China’s 12th National People’s Congress(NPC).From a global perspective,China’s role in the international community is rising.The nation accounts for a third of global economic growth and plays an increasingly
基金supported by the National Natural Science Foundation of China(92162218,42302101,42202099)the Guizhou Provincial Natural Science Foundation(ZK[2023]477)。
文摘Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)triangle in the southwestern margin of the Yangtze Block is a globally recognized carbonate-hosted Pb-Zn metallogenic province and also an essential part of the South China low-temperature metallogenic domain.This region has>30 million tons(Mt)Zn and Pb resources and shows the enrichment of dispersed metals,such as Ga,Ge,Cd,Se,and Tl.During the past 2 decades,abundant data on mineralization ages of Pb-Zn deposits within the SYG triangle have been documented based on various radioisotopic dating methods,resulting in significant progress in understanding the geodynamic background and ore formation of Pb-Zn deposits hosted in sedimentary rocks at SYG triangle.This paper provides a comprehensive summary of the geochronological results and Pb-Sr isotopic data regarding Pb-Zn deposits in the SYG triangle,which identified two distinct Pb-Zn mineralization periods influencing the dynamic processes associated with the expansion and closure of the Paleo-Tethys Ocean in the western margin of the Yangtze Block.The predominant phase of Pb-Zn mineralization at SYG triangle spanned from the Middle Triassic to Early Jurassic(226-191 Ma),which was intensely correlated with the large-scale basin fluid transport triggered by the closure of the Paleo-Tethys Ocean and Indosinian orogeny.The secondary Pb-Zn mineralization phase occurred during the Late Devonian to Late Carboniferous and was controlled by extensional structures associated with the expansion of the Paleo-Tethys Ocean.Further investigation is necessary to clarify the occurrence and potential factors involved in the Pb-Zn mineralization events during the Late Devonian to Late Carboniferous.
基金supported by the National Natural Science Foundation of China(42172010,42372071,41102037)。
文摘The Longshan orogenic belt is located in the southwestern margin of Ordos Basin at the junction zone between the Western Qinling and Northern Qilian orogenic belt.Voluminous Early Paleozoic magmatism in this area is of key significance for determining the Early Paleozoic tectonic evolution and deep crust-mantle structure.Previous studies mainly focused on the Paleozoic granites;the coeval mafic rocks in this area are still poorly understood.A set of Late Silurian intraplate tholeiitic basalts has been discovered in Longshan area,providing key evidence for the mantle source and deep geodynamic background in this area.The Late Silurian Angou basalt has similar geochemical features as intraplate tholeiitic basalt,with high Na_(2)O/K_(2)O ratios(5.22-8.25),enriched in large ion lithophile elements and LREE.In combination with their relatively evolved Sr-Nd isotopic composition[^(87)Sr/^(86)Sr(i)=0.7128-0.7140;ε_(Nd)(t)=-5.55 to-3.40],it is suggested that it originated from decompression melting of metasomatized enriched mantle in extensional setting.These results indicate that the mantle source in the junction zone of the West Qinling-North Qilian orogenic belt evolved from depleted to enriched with the continuation of Proto-Tethys subduction from the Cambrian to the Silurian.These results are of great significance to understanding the genesis of contemporaneous granite and the crust-mantle interaction in the junction zone between the Western Qinling and Northern Qilian orogenic belt.
文摘Introduction: Hypertension, a non-communicable disease, is a major public health threat worldwide, accounting for a high level of morbidity and mortality. Although it has been extensively published among the general population, further research is needed to understand the reality of hypertension within the custodial setting. This study aimed to investigate the factors associated with arterial hypertension in custodial settings in southern Benin in 2023. Methods: This was a cross-sectional, descriptive, analytical study held in prisons in southern Benin from March to April 2023, involving inmates selected by two-stage random sampling. In the first stage, four prisons out of the six in the southern region of Benin were selected by simple random sampling. In the second stage, the prisoners were selected by systematic random sampling, with the sampling frame being the numbered list of eligible prisoners in each prison selected. Data collected by observation and questionnaire survey were analyzed using Stata 11 software. Hypertension was defined as systolic blood pressure ≥ 140 mmHg and diastolic blood pressure ≥ 90 mmHg. Overweight was defined by a body mass index (weight/height<sup>2</sup> (kg/m<sup>2</sup>) ≥ 25. Factors associated with hypertension were identified by multiple logistic regression, at a 5% threshold of significance. Results: Altogether 336 inmates aged 37.55 ± 1.72 years were surveyed. The prevalence of hypertension in custodial settings in southern Benin in 2023 was 31.32% (95% CI [17.06;52.57]). Associated factors were inmate age (ORa = 3.36 95% CI: [1.94;5.85]) and abnormal waist circumference (ORa = 2.61 95% CI [1.27;5.40]). Conclusion: The prevalence of arterial hypertension in prisons of southern Benin (31.32%) is high when compared with the national average (25.9% (22.5-29.3)). The ministries of the Interior and Health need to collaborate to involve inmates in preventive strategies for non-communicable diseases, including hypertension.
文摘Introduction: Standard procedures for surgical fixation of proximal femoral fractures (PFF) require an image intensifier which in developing countries remains a luxury. We hypothesized that, with a well-codified technique, the Watson Jones approach (WJA) without image intensifier nor traction table, can allow open reduction and internal fixation (ORIF) of PFF using Dynamic hip screw (DHS), with satisfactory outcome. Patients and methods: Forty one consecutive patients (mean age 59.5 ± 21.6 years, 61% males) who were followed in a Teaching Hospital for PFF treated by ORIF using the WJA and DHS from January 2016 to December 2020 were reassessed. The outcome measures were the quality of the reduction, the positioning of the implants, the tip-apex distance (TAD), the rate and delay of consolidation, the functional results using Postel Merle d’Aubigné (PMA) score, the rate of surgical site infection (SSI) and the overall mortality. Logistic regression was used to determine factors associated with mechanical failure. Results: The mean follow-up period was 33.8 ± 15.0 months. Fracture reduction was good in 31 (75.6%) cases and acceptable in 8(19.5%) cases. Implant position was fair to good in 37 (90.2%) patients. The mean TAD was 26.1 ± 3.9 mm. Three patients developed SSI. Consolidation was achieved in 38 (92.6%) patients. The functional results were good to excellent in 80.5% of patients. The overall mortality rate was 7.3%. There were an association between mechanical failure and osteoporosis (p = 0.04), fracture reduction (p = 0.003), and TAD (p = 0.025). In multivariate logistic regression, no independent factors were predictive of mechanical failure. Conclusion: This study shows that ORIF using DHS for PFF via the Watson-Jones approach without an image intensifier can give satisfactory anatomical and functional outcomes in low-resource settings. It provides and validates a reliable and reproducible technique that deserves to be diffused to surgeons in austere areas over the world.
基金Funded by the National Natural Science Foundation of China(No.52370128)the Fundamental Research Funds for the Central Universities(No.2572022AW54)。
文摘This study identified castor oil and phosphate ester as effective retarders through setting time,tensile,and flexural tests,and determined their optimal dosages.The mechanism by which phosphate ester affects the setting time of polyurethane was further investigated using molecular dynamics simulations.Fourier transform infrared spectroscopy was also employed to systematically study the physical and chemical interactions between phosphate esters and polyurethane materials.The results demonstrate that a 1%concentration of phosphate ester provides the most effective retarding effect with minimal impact on the strength of polyurethane.When phosphate ester is added to the B component of the two-component polyurethane system,its interaction energy with component A decreases,as do the diffusion coefficient and aggregation degree of component B on the surface of component A.This reduction in interaction slows the setting time.Additionally,the addition of phosphate ester to polyurethane leads to the disappearance or weakening of functional groups,indicating competitive interactions within the phosphate ester components that inhibit the reaction rate.
基金supported by the National Key Research and Development Program of China (2022YFF0710705)the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2021-I2M-1-0 13)+2 种基金funding support from the Special Research Fund for Central UniversitiesPeking Union Medical College (3332022182)the 111 Project (B20095)
文摘Background:Nuclear receptor-binding SET domain 2(NSD2)is a histone methyltrans-ferase,that catalyzes dimethylation of lysine 36 of histone 3(H3K36me2)and is asso-ciated with active transcription of a series of genes.NSD2 is overexpressed in multiple types of solid human tumors and has been proven to be related to unfavorable prog-nosis in several types of tumors.Methods:We established a mouse model in which the NSD2 gene was conditionally knocked out in intestinal epithelial cells.We used azoxymethane and dextran sodium sulfate to chemically induce murine colorectal cancer.The development of colorectal tumors were investigated using post-necropsy quantification,immunohistochemistry,and enzyme-linked immunosorbent assay(ELISA).Results:Compared with wild-type(WT)control mice,NSD2^(fl/fl)-Vil1-Cre mice exhib-ited significantly decreased tumor numbers,histopathological changes,and cytokine expression in colorectal tumors.Conclusions:Conditional knockout of NSD2 in intestinal epithelial cells significantly inhibits colorectal cancer progression.
文摘The dramatic rise in the number of people living in cities has made many environmental and social problems worse.The search for a productive method for disposing of solid waste is the most notable of these problems.Many scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated ambiguity.The goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site selection.The characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these uncertainties.To tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s method.Following this,an intelligent algorithm is suggested.The steps of the suggested algorithm are explained with an example that explains itself.The compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their viability.This study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,respectively.It uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior literature.It is simpler for the decisionmakers to look at each option separately because the decision is uncertain.Comparing the computed results,it is discovered that they are consistent and dependable because of their preferred properties.
文摘The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolcanic rocks in the Belts that make up the Birimian Supergroup were intruded by granitoids during the Eburnean Orogeny.This research aims to classify granitoids in the Edikan Mine and ascertain the petrogenetic and geochemical characteristics of some auriferous granitoids in the wider Kumasi Basin,Ghana,to understand the implications for geodynamic settings.A multi-methods approach involving field studies,petrographic studies,and whole-rock geochemical analysis was used to achieve the goal of the study.Petrographic studies revealed a relatively high abundance of plagioclase and a low percentage of K-feldspars(anorthoclase and orthoclase)in the Fobinso samples,suggesting that the samples are granodioritic in nature,while the Esuajah samples showed relatively low plagioclase abundance and a high percentage in K-feldspars,indicating that they are granitic.The granitoids from the study areas are co-magmatic.The granitoids in Esuajah and Fobinso are generally enriched in large ion lithophile elements and light rare earth elements than high field strength elements,middle rare earth elements,and heavy rare earth elements,indicating mixing with crustal sources during the evolution of the granitoids.The granitoids were tectonically formed in a syn-collisional+VAG setting,which implies that they were formed in the subduction zone setting.Fobinso granodiorites showed S-type signatures with evidence of extensive crustal contamination,while the Esuajah granites showed I-type signatures with little or no crustal contamination and are peraluminous.Gold mineralization in the study area is structurally and lithologically controlled with shear zones,faulting,and veining as the principal structures controlling the mineralization.The late-stage vein,V3,in the Edikan Mine is characterized by a low vein angle and is mineralized.
基金supported by National Natural Science Foundation of China(42064002,42004013,42204006)the GuangxiNatural Science Foundation of China(2024GXNSFDA010041)+5 种基金Guangdong Basic and Applied Basic Research Foundation(2022A1515010469)Guangxi Key Laboratory of Spatial Information and Geomatics(Grant no.21-238-21-05)the Open Fund of Hubei Luojia Laboratory(230100019,230100020)The GNSS observation data are provided by Crustal Movement Observation Network of China(CMONC)The GRACE/GFO mascon gravimetry data products are provided by NASA Jet Propulsion Laboratory/California Institute of TechnologyThe GLDAS data products are provided by NASA Earthdata.
文摘Vertical position changes of ground-based Global Navigation Satellite System(GNSS) stations have been used to study regional terrestrial water storage(TWS) changes. However, the feasibility is still unclear in many areas due to diverse local effects. This study aims to evaluate the capability of GNSS vertical displacements in monitoring hydrological variations in four climate settings over Chinese mainland. The spatial and temporal variations of hydrological load-induced(HYDL) vertical displacements at 208 GNSS sites during 2011-2020 were analyzed by comparing with Gravity Recovery and Climate Experiment(GRACE)/GRACE Follow-On(GFO) and Global Land Data Assimilation System(GLDAS) derived TWS changes. The results indicate that GNSS vertical positions show different capabilities in capturing seasonal and non-seasonal hydrological dynamics in different climate regions. Among the four climatic settings, the subtropical monsoon climate(SMC) region, with the largest deformation fluctuation(the regional mean root mean square(RMS) is 7.97 mm), has the highest regional mean HYDL-GRACE and HYDL-GLDAS anti-correlation coefficients(CCs) of-0.47 and-0.45 at the seasonal scale, respectively. For the individual GNSS site, the number of the sites with CC <-0.40 between HYDL and GRACE/GLDASderived TWS changes accounts for 55.1% and 55.1%(SMC), 13.0% and 7.4%(temperate monsoon climate, TMC), 6.7% and 13.3%(temperate continental climate, TCC), 32.3% and 38.7%(plateau climate,PC), respectively. For the non-seasonal term, although the proportion with CC <-0.40 in each climate type decreases mainly due to the influence of local geodynamic and human activities, especially in the SMC and PC regions, GNSS site vertical deformations still show good capability in monitoring hydrological extremes. The results provide valuable information for better application of GNSS to hydrology.
基金This retrospective analysis incorporated data from two clinical trials(CTR20220854 and CTR20222843)sponsored by Chongqing Chenan Biopharmaceutical Co.,Ltd.and Jiangsu Hengrui Pharmaceuticals Co.,Ltd.However,these sponsors did not partake in the study design,data interpretation,or manuscript preparation.
文摘BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques before entry into the market.Typically,blood glucose(BG)levels are maintained at 5%below baseline to suppress endogenous insulin secretion in healthy volunteers.However,in scenarios where BG baseline is relatively low,maintaining it at 5%below baseline can increase hypoglycemic risk.Consequently,we adjusted to maintain it at 2.5%below a baseline of<4.00 mmol/L.It remains uncertain whether this adjustment impacts endogenous insulin inhibition or the PD of study insulin.AIM To evaluate and compare the PD and C-peptide status using two different target BG setting methods.METHODS Data came from euglycemic clamp trials assessing the PK/PD of insulin aspart(IAsp)in healthy participants.Target BG was set at 2.5%below baseline for those with a basal BG of<4.00 mmol/L(group A),and at 5%below baseline for others(group B).The area under the curve(AUC)of IAsp(AUC_(IAsp,0-8 h))and GIR from 0 to 8 hours(AUCGIR,0-8 h)was used to characterize the PK and PD of IAsp,respectively.The C-peptide reduction and PK/PD of IAsp were compared between the two groups.RESULTS Out of 135 subjects,15 were assigned to group A and 120 to group B;however,group B exhibited higher basal Cpeptide(1.59±0.36 vs 1.32±0.42 ng/mL,P=0.006).Following propensity score matching to adjust for basal Cpeptide differences,71 subjects(15 in group A and 56 in group B)were analyzed.No significant differences were observed in demographics,IAsp dosage,or clamp quality.Group B showed significantly higher baseline(4.35±0.21 vs 3.91±0.09 mmol/L,P<0.001),target(4.13±0.20 vs 3.81±0.08 mmol/L,P<0.001),and clamped(4.10±0.17 vs 3.80±0.06 mmol/L,P<0.001)BG levels.Both groups exhibited comparable C-peptide suppression(32.5%±10.0%vs 35.6%±12.1%,P=0.370)and similar IAsp activity(AUCGIR,0-8 h:1433±400 vs 1440±397 mg/kg,P=0.952)under nearly equivalent IAsp exposure(AUC_(IAsp,0-8 h):566±51 vs 571±85 ng/mL×h,P=0.840).CONCLUSION Maintaining BG at 2.5%below a baseline of<4.00 mmol/L did not compromise the endogenous insulin suppression nor alter the observed pharmacodynamic effects of the study insulin.
基金Supported by Traditional Chinese medicine foundation of Zhejiang province:Clinical Study on the Correlation Between Tourette Syndrome and Anatomical Changes in the Atlantoaxial Joint(2010ZB162)Medical Health Science and Technology Project of Zhejiang Provincial Health Commission:Study on Protein Fingerprinting of Tourette Syndrome(2011KYB142)+1 种基金Renowned Traditional Chinese Medicine Expert Inheritance Studio Construction Project of Zhejiang province(No.GZS2020049)Key Disciplines of Traditional Chinese Medicine Foundation of Zhejiang Province(2012-XK-D20)。
文摘OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 into three groups:group A(acupuncture combined with atlantoaxial joint bone setting therapy group),group B(acupuncture group),and group C(tiapride group).After two months of treatment,the Yale global tic severity scale(YGTSS)score reduction,improvement in social function impairment,clinical efficacy,and long-term efficacy in the three groups were compared.RESULTS:After treatment,in the analysis of YGTSS score reduction,social function impairment improvement,the clinical control rate,and long-term efficacy,the results were all Group A>Group B>Group C,with a statistically significant difference(P<0.05).However,the total clinical efficacy of treatment in group A(94.9%)was not significantly different from that in group B(91.8%).Adverse reactions did not occur in groups A and B,and several adverse reactions occurred in 29%(n=58)of the group C patients.CONCLUSION:Compared with traditional drug therapy,acupuncture combined with atlantoaxial joint bone setting therapy has better clinical and long-term efficacy.This treatment strategy can improve the social function of children and prevent adverse reactions to drugs.
文摘The Paleoproterozoic basement of Zoukougbeu in central-western Côte d’Ivoire lies within the southern Baoulé-Mossi domain of the West African Craton,a key area for understanding the crustal evolution associated with the Eburnean orogeny.However,the petrogenesis and geodynamic context of the granitoid intrusions in this region remain poorly constrained,despite their potential sig nificance for regional crustal growth and mineralization.This study integrates petrographic and whole-rock geochemical data from drill-core samples to clar-ify the origin and tectonic evolution of these rocks.The lithological assemblage includes granodiorite,granite,diorite,gneiss,and pegmatite,variably deformed and hydrothermally altered.Petrographic analysis reveals plagioclase-quartzbiotiteamphibole assemblages overprinted by chlorite-epidote alteration,in-dicating greenschist-to amphibolite-facies metamorphism.Geochemically,the rocks define a calc-alkaline,metaluminous to slightly peraluminous suite with tonalite-trondhjemite-granodiorite(TTG)affinity.Their enrichment in largeion lithophile elements and depletion in Nb-Ta-Ti,coupled with LREE enrich-ment and negative Eu anomalies,are typical of subduction-related magmatism.These signatures indicate that the Zoukougbeu granitoids originated from par-tial melting of hydrated basaltic crust with minor mantle input in a continental volcanic-arc setting during the Eburnean orogeny(~2.1-2.0 Ga).This finding refines the current understanding of Paleoproterozoic crustal evolution in the southern West African Craton and highlights the role of arc magmatism in its stabilization.
文摘Cardiac arrest is associated with high rates of mortality and significant long-term neurological disability in survivors.Timely and accurate assessment following successful resuscitation is critical for optimizing outcomes.Imaging plays a central role in this evaluation process,providing crucial insights into the etiology of arrest,the extent of cerebral and cardiac injury,and guiding both acute management and long-term prognostication.A structured,multimodal imaging approach utilizing tools such as computed tomography,magnetic resonance imaging,echocardiography,and angiography is increasingly recognized as es-sential in the post-cardiac arrest setting.This review aims to consolidate current evidence related to the use of various imaging modalities across neurological,cardiac and systemic contexts.Particular emphasis is placed on the prognostic value and optimal timing of neuroimaging,the detection of potentially reversible causes of arrest,such as coronary occlusion or pulmonary embolism,and the emerging role of whole-body imaging in evaluating patients with non-traumatic out-of-hospital cardiac arrest.
文摘The present study of metabasalts was carried out to understand the mantle source and geodynamic setting of the Mahakoshal Group in the Central Indian Tectonic Zone.In this study,we present detailed field,petrography,and whole rock geochemistry of the Mahakoshal metabasalts.The Mahakoshal metabasalts are sub-alkaline in nature and belong to the tholeiitic series of rocks.The variation in rareearth element patterns of metabasalts indicates the different degrees of partial melting at shallow as well as deeper depths.Further,Eu/Eu*varies from 0.8 to 1.1(except sample KP-144=0.3),Ce/Ce*varies from 0.97 to 1.05,showing no cerium anomaly,and Nb/Nb*ranges from 0.7 to 1.3(except KP-144=0.1).The magnesium number(Mg#)varies from 0.2 to 0.3,which is quite low,indicating the evolved nature of the metabasalts.The studied metabasalts show E-MORB to OIB-type affinities,which are placed in the trench-distal back-arc setting.The opening of the Mahakoshal Basin is due to retreating orogen in the accretionary orogen setting and is contemporaneous with the assembly of the Columbia Supercontinent(~2.1-1.8 Ga).Hence,field,petrographic,and geochemical signatures indicate that the Mahakoshal basin opened as a back-arc rift basin on the Bundelkhand Craton,and that metabasalts are derived from the mantle that underwent variable degrees of partial melting at different depths.
基金the financial support for this research provided by the National Natural Science Foundation of China(Grant Nos.52275470,124115301,and 52105458)the Natural Science Foundation of Beijing(Grant No.3222009).
文摘Vibration cutting has emerged as a promising method for creating surface functional microstructures.However,achieving precise tool setting is a time-consuming process that significantly impacts process efficiency.This study proposes an intelligent approach for tool setting in vibration cutting using machine vision and hearing,divided into two steps.In the first step,machine vision is employed to achieve rough precision in tool setting within tens of micrometers.Subsequently,in the second step,machine hearing utilizes sound pickup to capture vibration audio signals,enabling fine tool adjustment within 1μm precision.The relationship between the spectral intensity of vibration audio and cutting depth is analyzed to establish criteria for tool–workpiece contact.Finally,the efficacy of this approach is validated on an ultra-precision platform,demonstrating that the automated tool-setting process takes no more than 74 s.The total cost of the vision and hearing sensors is less than$1500.
文摘The implementation of Countermeasure Techniques(CTs)in the context of Network-On-Chip(NoC)based Multiprocessor System-On-Chip(MPSoC)routers against the Flooding Denial-of-Service Attack(F-DoSA)falls under Multi-Criteria Decision-Making(MCDM)due to the three main concerns,called:traffic variations,multiple evaluation criteria-based traffic features,and prioritization NoC routers as an alternative.In this study,we propose a comprehensive evaluation of various NoC traffic features to identify the most efficient routers under the F-DoSA scenarios.Consequently,an MCDM approach is essential to address these emerging challenges.While the recent MCDM approach has some issues,such as uncertainty,this study utilizes Fuzzy-Weighted Zero-Inconsistency(FWZIC)to estimate the criteria weight values and Fuzzy Decision by Opinion Score Method(FDOSM)for ranking the routers with fuzzy Single-valued Neutrosophic under names(SvN-FWZIC and SvN-FDOSM)to overcome the ambiguity.The results obtained by using the SvN-FWZIC method indicate that the Max packet count has the highest importance among the evaluated criteria,with a weighted score of 0.1946.In contrast,the Hop count is identified as the least significant criterion,with a weighted score of 0.1090.The remaining criteria fall within a range of intermediate importance,with enqueue time scoring 0.1845,packet count decremented and traversal index scoring 0.1262,packet count incremented scoring 0.1124,and packet count index scoring 0.1472.In terms of ranking,SvN-FDOSM has two approaches:individual and group.Both the individual and group ranking processes show that(Router 4)is the most effective router,while(Router 3)is the lowest router under F-DoSA.The sensitivity analysis provides a high stability in ranking among all 10 scenarios.This approach offers essential feedback in making proper decisions in the design of countermeasure techniques in the domain of NoC-based MPSoC.
基金supported by Jiangsu Provincial Key Research and Development Program(No.BE2023014-4).
文摘During the automated placement process of dry fibers,the positioning and fixation of dry fiber gauze belts are achieved by spraying setting agents.The amount of the setting agent is difficult to control when it is sprayed manually.Furthermore,it can also affect the permeability of the preform,resin injection and the quality of the vacuum assisted resin infusion(VARI)molding,resulting in a decrease in the mechanical properties of composite materials.This study utilizes dry fiber automated placement equipment and an automated spraying system to manufacture preform structures,followed by VARI process to prepare composite samples with varying setting agent contents.Subsequently,mechanical characterization including interlaminar shear,bending and tensile testing is conducted to investigate the influence of setting agent content on both the manufacturing process and the mechanical properties of composite products.The results show that the interlaminar shear strength,bending strength and tensile strength of the sample gradually decrease with the increase of the content of the setting agent.The optimal setting agent content for automated laying of dry fiber is determined to be 4%-6%,balancing the preformed body’s layup quality and its impact on mechanical properties.Compared with agent-free samples,this range results in reductions of 3% in interlaminar shear strength,9% in bending strength,11% in bending modulus,and 13%-16% in tensile strength.
基金supported by the National Natural Science Foundation of China(Nos.72004147,82204941,and U23B2062)the National Key Researchand Development Program(No.2023YFC3502604)the Natural Science Foundation of Beijing(No.L232033).
文摘Clinical diagnosis for complex disease conditions is a complicated decision process involving systematic inference and differentiation.Artificial Intelligence(Al)models have been a widely established approach to help improve the efficiency of various kinds of clinical decision tasks(e.g.,diagnosis,treatment,and prognosis).However,due to the critical requirement of time efficiency,lack of sufficient information,and high probability of comorbid diseases in Outpatient and Emergency Settings(OES),it is still challenging to build clinically feasible Al models using the free text clinical records in OES for complex disease conditions,such as neurosurgery.Here we propose an Al diagnosis model,named LLM4DEU,for neurosurgery disease differentiations by fine-tuning a large language model(i.e.,ChatGLM)using the Department of Neurosurgery,the Beijing Tiantan Hospital OES electronic health records.LLM4DEU obtained state-of-the-art performance on clinical diagnosis with a F1 score of 78.53%,which is superior to five well-known baselines(including deep learning models).In addition,we evaluated the actual performance of the model by case studies on the diagnosis of specific neurosurgical diseases(e.g.,subdural hematoma,cerebral hemorrhage,and cerebral infarction).The experimental results show that the LLM4DEU model has significant advantages in diagnosing low-incidence disease conditions,and comparative analyses with clinical experts confirm the predictive power of the model in neurosurgical diagnosis.
文摘Concentrated solar thermal power generation has been experimentally tested in advanced countries for a period of time.This paper demonstrates how this technology can be improved by using water molecules as a medium to drive traditional generator sets for energy conversion,thereby simultaneously improving the energy conversion rate.Additionally,a novel contribution is made by incorporating a magic number 4 to enhance the focusing efficiency of Fresnel lenses,which drives improvements in power generation output and QE(Quantum Efficiency).
