OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 i...OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 into three groups:group A(acupuncture combined with atlantoaxial joint bone setting therapy group),group B(acupuncture group),and group C(tiapride group).After two months of treatment,the Yale global tic severity scale(YGTSS)score reduction,improvement in social function impairment,clinical efficacy,and long-term efficacy in the three groups were compared.RESULTS:After treatment,in the analysis of YGTSS score reduction,social function impairment improvement,the clinical control rate,and long-term efficacy,the results were all Group A>Group B>Group C,with a statistically significant difference(P<0.05).However,the total clinical efficacy of treatment in group A(94.9%)was not significantly different from that in group B(91.8%).Adverse reactions did not occur in groups A and B,and several adverse reactions occurred in 29%(n=58)of the group C patients.CONCLUSION:Compared with traditional drug therapy,acupuncture combined with atlantoaxial joint bone setting therapy has better clinical and long-term efficacy.This treatment strategy can improve the social function of children and prevent adverse reactions to drugs.展开更多
Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)tria...Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)triangle in the southwestern margin of the Yangtze Block is a globally recognized carbonate-hosted Pb-Zn metallogenic province and also an essential part of the South China low-temperature metallogenic domain.This region has>30 million tons(Mt)Zn and Pb resources and shows the enrichment of dispersed metals,such as Ga,Ge,Cd,Se,and Tl.During the past 2 decades,abundant data on mineralization ages of Pb-Zn deposits within the SYG triangle have been documented based on various radioisotopic dating methods,resulting in significant progress in understanding the geodynamic background and ore formation of Pb-Zn deposits hosted in sedimentary rocks at SYG triangle.This paper provides a comprehensive summary of the geochronological results and Pb-Sr isotopic data regarding Pb-Zn deposits in the SYG triangle,which identified two distinct Pb-Zn mineralization periods influencing the dynamic processes associated with the expansion and closure of the Paleo-Tethys Ocean in the western margin of the Yangtze Block.The predominant phase of Pb-Zn mineralization at SYG triangle spanned from the Middle Triassic to Early Jurassic(226-191 Ma),which was intensely correlated with the large-scale basin fluid transport triggered by the closure of the Paleo-Tethys Ocean and Indosinian orogeny.The secondary Pb-Zn mineralization phase occurred during the Late Devonian to Late Carboniferous and was controlled by extensional structures associated with the expansion of the Paleo-Tethys Ocean.Further investigation is necessary to clarify the occurrence and potential factors involved in the Pb-Zn mineralization events during the Late Devonian to Late Carboniferous.展开更多
The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolc...The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolcanic rocks in the Belts that make up the Birimian Supergroup were intruded by granitoids during the Eburnean Orogeny.This research aims to classify granitoids in the Edikan Mine and ascertain the petrogenetic and geochemical characteristics of some auriferous granitoids in the wider Kumasi Basin,Ghana,to understand the implications for geodynamic settings.A multi-methods approach involving field studies,petrographic studies,and whole-rock geochemical analysis was used to achieve the goal of the study.Petrographic studies revealed a relatively high abundance of plagioclase and a low percentage of K-feldspars(anorthoclase and orthoclase)in the Fobinso samples,suggesting that the samples are granodioritic in nature,while the Esuajah samples showed relatively low plagioclase abundance and a high percentage in K-feldspars,indicating that they are granitic.The granitoids from the study areas are co-magmatic.The granitoids in Esuajah and Fobinso are generally enriched in large ion lithophile elements and light rare earth elements than high field strength elements,middle rare earth elements,and heavy rare earth elements,indicating mixing with crustal sources during the evolution of the granitoids.The granitoids were tectonically formed in a syn-collisional+VAG setting,which implies that they were formed in the subduction zone setting.Fobinso granodiorites showed S-type signatures with evidence of extensive crustal contamination,while the Esuajah granites showed I-type signatures with little or no crustal contamination and are peraluminous.Gold mineralization in the study area is structurally and lithologically controlled with shear zones,faulting,and veining as the principal structures controlling the mineralization.The late-stage vein,V3,in the Edikan Mine is characterized by a low vein angle and is mineralized.展开更多
BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques...BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques before entry into the market.Typically,blood glucose(BG)levels are maintained at 5%below baseline to suppress endogenous insulin secretion in healthy volunteers.However,in scenarios where BG baseline is relatively low,maintaining it at 5%below baseline can increase hypoglycemic risk.Consequently,we adjusted to maintain it at 2.5%below a baseline of<4.00 mmol/L.It remains uncertain whether this adjustment impacts endogenous insulin inhibition or the PD of study insulin.AIM To evaluate and compare the PD and C-peptide status using two different target BG setting methods.METHODS Data came from euglycemic clamp trials assessing the PK/PD of insulin aspart(IAsp)in healthy participants.Target BG was set at 2.5%below baseline for those with a basal BG of<4.00 mmol/L(group A),and at 5%below baseline for others(group B).The area under the curve(AUC)of IAsp(AUC_(IAsp,0-8 h))and GIR from 0 to 8 hours(AUCGIR,0-8 h)was used to characterize the PK and PD of IAsp,respectively.The C-peptide reduction and PK/PD of IAsp were compared between the two groups.RESULTS Out of 135 subjects,15 were assigned to group A and 120 to group B;however,group B exhibited higher basal Cpeptide(1.59±0.36 vs 1.32±0.42 ng/mL,P=0.006).Following propensity score matching to adjust for basal Cpeptide differences,71 subjects(15 in group A and 56 in group B)were analyzed.No significant differences were observed in demographics,IAsp dosage,or clamp quality.Group B showed significantly higher baseline(4.35±0.21 vs 3.91±0.09 mmol/L,P<0.001),target(4.13±0.20 vs 3.81±0.08 mmol/L,P<0.001),and clamped(4.10±0.17 vs 3.80±0.06 mmol/L,P<0.001)BG levels.Both groups exhibited comparable C-peptide suppression(32.5%±10.0%vs 35.6%±12.1%,P=0.370)and similar IAsp activity(AUCGIR,0-8 h:1433±400 vs 1440±397 mg/kg,P=0.952)under nearly equivalent IAsp exposure(AUC_(IAsp,0-8 h):566±51 vs 571±85 ng/mL×h,P=0.840).CONCLUSION Maintaining BG at 2.5%below a baseline of<4.00 mmol/L did not compromise the endogenous insulin suppression nor alter the observed pharmacodynamic effects of the study insulin.展开更多
Vibration cutting has emerged as a promising method for creating surface functional microstructures.However,achieving precise tool setting is a time-consuming process that significantly impacts process efficiency.This...Vibration cutting has emerged as a promising method for creating surface functional microstructures.However,achieving precise tool setting is a time-consuming process that significantly impacts process efficiency.This study proposes an intelligent approach for tool setting in vibration cutting using machine vision and hearing,divided into two steps.In the first step,machine vision is employed to achieve rough precision in tool setting within tens of micrometers.Subsequently,in the second step,machine hearing utilizes sound pickup to capture vibration audio signals,enabling fine tool adjustment within 1μm precision.The relationship between the spectral intensity of vibration audio and cutting depth is analyzed to establish criteria for tool–workpiece contact.Finally,the efficacy of this approach is validated on an ultra-precision platform,demonstrating that the automated tool-setting process takes no more than 74 s.The total cost of the vision and hearing sensors is less than$1500.展开更多
Point-of-care ultrasound(POCUS) is recognized as a valuable diagnostic tool,especially in resourcelimited settings(RLS).POCUS provides rapid diagnostic information that enables health professionals to make critical de...Point-of-care ultrasound(POCUS) is recognized as a valuable diagnostic tool,especially in resourcelimited settings(RLS).POCUS provides rapid diagnostic information that enables health professionals to make critical decisions at the bedside.^([1]) Despite the welldocumented benefits of POCUS,access to longitudinal,comprehensive training programs and a lack of trainee feedback are barriers to the widespread use of this technology in such settings.^([2])展开更多
Breast cancer is the leading cause of cancer-related mortality in women globally,with its incidence continuing to rise,particularly in low-and middle-income countries,presenting a significant public health challenge w...Breast cancer is the leading cause of cancer-related mortality in women globally,with its incidence continuing to rise,particularly in low-and middle-income countries,presenting a significant public health challenge worldwide[1].According to data from the Institute for Health Metrics and Evaluation(IHME)and the World Health Organization(WHO),the gap in access to healthcare services between high-and low-income countries contributes to delayed detection,increased incidence of advanced-stage disease,and,consequently,higher mortality rates(up to 50%higher compared to high-income countries)[1,2].This translates into inequalities in access to screening and early diagnosis methods,which exacerbate the burden of this disease in low-resource settings where infrastructure,funding,and access to trained professionals are limited[3].展开更多
During the automated placement process of dry fibers,the positioning and fixation of dry fiber gauze belts are achieved by spraying setting agents.The amount of the setting agent is difficult to control when it is spr...During the automated placement process of dry fibers,the positioning and fixation of dry fiber gauze belts are achieved by spraying setting agents.The amount of the setting agent is difficult to control when it is sprayed manually.Furthermore,it can also affect the permeability of the preform,resin injection and the quality of the vacuum assisted resin infusion(VARI)molding,resulting in a decrease in the mechanical properties of composite materials.This study utilizes dry fiber automated placement equipment and an automated spraying system to manufacture preform structures,followed by VARI process to prepare composite samples with varying setting agent contents.Subsequently,mechanical characterization including interlaminar shear,bending and tensile testing is conducted to investigate the influence of setting agent content on both the manufacturing process and the mechanical properties of composite products.The results show that the interlaminar shear strength,bending strength and tensile strength of the sample gradually decrease with the increase of the content of the setting agent.The optimal setting agent content for automated laying of dry fiber is determined to be 4%-6%,balancing the preformed body’s layup quality and its impact on mechanical properties.Compared with agent-free samples,this range results in reductions of 3% in interlaminar shear strength,9% in bending strength,11% in bending modulus,and 13%-16% in tensile strength.展开更多
This study investigates the facies development and sedimentology of the Late Permian Chhidru Formation,a mixed carbonate-siliciclastic unit exposed in the Western Salt Range,Potwar Basin,Pakistan.The formation is subd...This study investigates the facies development and sedimentology of the Late Permian Chhidru Formation,a mixed carbonate-siliciclastic unit exposed in the Western Salt Range,Potwar Basin,Pakistan.The formation is subdivided into four lithological units reflecting lateral variability,with thicknesses and lithologies ranging from fossiliferous sandy limestone to interbedded limestone and sandstone.These successions record a depositional shift from a carbonate platform to mixed carbonate-clastic,and ultimately,clastic-dominated environments.Lithostratigraphy suggests deposition on the underlying Wargal Limestone carbonates during a Late Permian sea-level fall on the northwest Indian margin of Gondwana.Similar Permian successions with identical lithological characteristics are documented in the Persian Gulf(Dalan Formation),Arabian Platform(Khuff Formation),and Iran(Nesen and Hambust formations).Petrographic analysis reveals deposition in the distal middle to proximal inner shelf settings of a carbonate-siliciclastic mixed,unrimmed platform.Based on identified foraminiferal assemblages,the Chhidru Formation's age is estimated to range from the late Wuchiapingian to Changhsingian stages of the Lopingian epoch.展开更多
Circumlunar abort trajectories constitute a vital contingency return strategy during the translunar phase of crewed lunar missions.This paper proposes a methodology for constructing the solution set of the circumlunar...Circumlunar abort trajectories constitute a vital contingency return strategy during the translunar phase of crewed lunar missions.This paper proposes a methodology for constructing the solution set of the circumlunar abort trajectory and leverages its advantageous properties to address the optimization design problem of abort trajectories.Initially,a solution set of all feasible abort trajectories,originating from an abort point on the nominal trajectory and complying with fundamental reentry constraints,is formulated through the introduction of two novel design parameters.Subsequently,the geometric characteristics of the solution set,as well as the distributional properties of key iterative constraint responses,including flight time and velocity increment,are analyzed.Finally,the characteristics exhibited in the solution set are employed to directly identify the design parameters of the abort trajectories with minimum flight time and velocity increment,thereby providing solutions to two distinct types of optimization problems.The simulation results for a variety of nominal trajectories,encompassing the reconstruction and redesign of the Apollo13 abort trajectory,validate the proposed method,demonstrating its ability to directly generate optimal abort trajectories.The method proposed in this paper investigates feasible abort trajectories from a global perspective,providing both a framework and convenience for mission planning and iterative optimization in abort trajectory design.展开更多
[Objectives]To provide a reference for the efficient use of wild Paeonia suffruticosa germplasm resources and the scientific selection of parents.[Methods]This study systematically evaluated cross-compatibility by con...[Objectives]To provide a reference for the efficient use of wild Paeonia suffruticosa germplasm resources and the scientific selection of parents.[Methods]This study systematically evaluated cross-compatibility by conducting interspecific crosses among the major wild species subsect.Delavayanae(Paeonia delavayi,Paeonia lutea,Paeonia potaninii,and Paeonia ludlowii)as well as reciprocal crosses between these species and cultivated varieties from the subsect.Vaginatae.[Results]Crosses among P.delavayi,P.lutea,and P.potaninii generally exhibited good seed set,with the resulting seeds showing a high emergence rate.In contrast,crosses involving P.ludlowii as a parent produced only a limited number of seeds,none of which germinated.In crosses with cultivated varieties where the wild species served as the maternal parent,the average seed set ranked as follows:P.lutea>P.delavayi>P.ludlowii>P.potaninii.When wild species were used as paternal parent,the average seed set ranked as follows:P.potaninii>P.lutea>P.delavayi>P.ludlowii.On the whole,most crosses between wild species of subsect.Delavayanae and cultivated varieties achieved normal seed set,demonstrating a certain degree of cross-compatibility.However,when the wild species served as the maternal parent,both the seed set and seedling emergence rate were superior to those in the reciprocal crosses(with wild species as the paternal parent).[Conclusions]Significant differences in cross-compatibility were observed among species within Paeonia subsect.Delavayanae.In addition,a significant maternal effect was identified in crosses between wild species of this subsection and cultivated varieties.These findings suggest that by selecting highly compatible combinations,there remains considerable potential for utilizing these wild species in peony breeding.展开更多
Deep learning attentionmechanisms have achieved remarkable progress in computer vision,but still face limitations when handling images with ambiguous boundaries and uncertain feature representations.Conventional atten...Deep learning attentionmechanisms have achieved remarkable progress in computer vision,but still face limitations when handling images with ambiguous boundaries and uncertain feature representations.Conventional attention modules such as SE-Net,CBAM,ECA-Net,and CA adopt a deterministic paradigm,assigning fixed scalar weights to features without modeling ambiguity or confidence.To overcome these limitations,this paper proposes the Fuzzy Attention Network Layer(FANL),which integrates intuitionistic fuzzy set theory with convolutional neural networks to explicitly represent feature uncertainty through membership(μ),non-membership(ν),and hesitation(π)degrees.FANLconsists of four coremodules:(1)feature dimensionality reduction via global pooling,(2)fuzzymodeling using learnable clustering centers,(3)adaptive attention generation through weighted fusion of fuzzy components,and(4)feature refinement through residual connections.A cross-layer guidance mechanism is further introduced to enhance hierarchical feature propagation,allowing high-level semantic features to incorporate fine-grained texture information from shallow layers.Comprehensive experiments on three benchmark datasets—PathMNIST-30000,full PathMNIST,and Blood MNIST—demonstrate the effectiveness and generalizability of FANL.The model achieves 84.41±0.56%accuracy and a 1.69%improvement over the baseline CNN while maintaining lightweight computational complexity.Ablation studies show that removing any component causes a 1.7%–2.0%performance drop,validating the synergistic contribution of each module.Furthermore,FANL provides superior uncertainty calibration(ECE=0.0452)and interpretable selective prediction under uncertainty.Overall,FANL presents an efficient and uncertaintyaware attention framework that improves both accuracy and reliability,offering a promising direction for robust visual recognition under ambiguous or noisy conditions.展开更多
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations...Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.展开更多
To elucidate the geographical differentiation characteristics and driving mechanisms of Dissolved Organic Matter(DOM)in typical rivers,this study conducted a multi-spectral investigation on three representative river ...To elucidate the geographical differentiation characteristics and driving mechanisms of Dissolved Organic Matter(DOM)in typical rivers,this study conducted a multi-spectral investigation on three representative river types within Shandong Province:The mountainous Dawen River,the plain Tuhai River,and the artificial East Grand Canal.The DOM composition was analyzed using Ultraviolet-Visible(UV-Vis)absorption spectroscopy,Excitation-Emission Matrix(EEM)fluorescence spectroscopy,and parallel factor analysis(PARAFAC),while Principal Component Analysis(PCA)was employed to quantify the synergistic effects of natural processes and anthropogenic activities.Results revealed significant spatial heterogeneity in DOM composition and sources.The plain river exhibited the highest aromaticity(humic-like components:43.3%)due to long-term agricultural non-point source inputs and urban wastewater discharge.The mountain stream,shaped by complex terrain and relatively intact ecosystems,was dominated by autochthonous DOM derived from microbial metabolism,with higher Fluorescence Index(FI=2.12)and biological index(BIX=1.35)than other river types.The artificial canal retained protein-like components(64.2%),largely attributed to winter hydrological stagnation and disturbances from shipping activities.Further analysis demonstrated that geographical settings(e.g.,mountain terrain)and anthropogenic activities(e.g.,agriculture,shipping)jointly regulated DOM composition by altering the balance between input and transformation processes.Integrated fluorescence parameters and PCA results suggested differentiated management strategies:protecting ecological integrity in mountain streams to sustain selfpurification,enhancing non-point source interception in plain rivers,and mitigating shipping pollution in canals.This study systematically reveals the natural-anthropogenic coupling mechanisms driving DOM dynamics in northern China rivers,providing critical insights for precision water environment management at the watershed scale.展开更多
The quality of cardiopulmonary resuscitation(CPR) significantly influences survival and neurological outcomes in patients with cardiac arrest(CA).Although mechanical chest compression devices and extracorporeal cardio...The quality of cardiopulmonary resuscitation(CPR) significantly influences survival and neurological outcomes in patients with cardiac arrest(CA).Although mechanical chest compression devices and extracorporeal cardiopulmonary resuscitation(ECPR) have demonstrated some benefits,high-quality manual CPR remained the essential first step,particularly in resource-limited settings.In this study,we examined whether opportunities existed to improve manual CPR performance using preliminary data from our recent survey conducted in a province in western China.We aim to emphasize the importance of improving manual CPR quality before implementing advanced interventions.展开更多
The soft actuator is characterized by high safety,flexibility,and adaptability.It is capable of both active and passive defor-mations.This paper presents a discrete degree of freedom(DOF)method for soft actuators to r...The soft actuator is characterized by high safety,flexibility,and adaptability.It is capable of both active and passive defor-mations.This paper presents a discrete degree of freedom(DOF)method for soft actuators to reveal DOF characteristics.The method draws on the superposition mechanism of the deformation characteristics of the sarcomere in the skeletal muscles of living organisms.Firstly,the multi-DOF deformation characteristics of the soft actuator are discretized into superimposed combinations of single-DOF micro-units.Then,the soft actuator was determined to contain deformation characteristics such as extension-contraction,bending,and twisting.Eighteen types of micro-units with basic deforma-tion characteristics were obtained depending on the axis and orientation.Further,the mapping relationship between the combination of micro-units and the motion characteristics of the soft actuator based on the GF set theory was established.Finally,an active-passive DOF co-structured soft actuator(APCSA)was developed.The graphical approach analyzes the experimental results,and it can be concluded that active and passive DOFs can coexist in the composite deformation of the soft actuator.展开更多
For mission-oriented unmanned aerial vehicle(UAV)swarms,mission capability assessment provides an important reference in the design and development process,and is a precondition for mission success.For this multi-crit...For mission-oriented unmanned aerial vehicle(UAV)swarms,mission capability assessment provides an important reference in the design and development process,and is a precondition for mission success.For this multi-criteria decisionmaking(MCDM)problem,the current literature lacks a way to unambiguously present criteria and the popular fuzzy analytic network process(ANP)approaches neglect the hesitancy of subjective judgments.To fill these research gaps,an MCDM method based on unified architecture framework(UAF)and interval-valued spherical fuzzy ANP(IVSF-ANP)is proposed in this paper.Firstly,selected viewpoints in UAF are extended to construct criteria models with standardized representation.Secondly,interval-valued spherical fuzzy sets are introduced to ANP to weight interdependent criteria,handling fuzziness and hesitancy in pairwise comparisons.A method of adjusting weights of experts based on their decision similarities is also included in this process to reduce ambiguity brought by multiple experts.Next,performance characteristics are non-linearly transformed regarding to expectations to get final results.This proposition is applied to assess the mission capability of UAV swarms to search and strike surface vessels.Comparative analysis shows that the proposed method is valid and reasonable.展开更多
In order to study the application effect of microbial fertilizer and compound fertilizer mixed application on microirrigation apple, three types of fertilizers were applied in spring which were urea（CK, 15 kg/plant）...In order to study the application effect of microbial fertilizer and compound fertilizer mixed application on microirrigation apple, three types of fertilizers were applied in spring which were urea（CK, 15 kg/plant）, microbial fertilizer（5.0 kg/plant）,microbial fertilizer and compound fertilizer mixed（each 2.5 kg/plant） to study the effect of different fertilizer treatments on yield, fruit quality, flowering and fruit setting of Xinshijie apple. The results showed that application of microbial fertilizer could increase the yield, fruit weight and fruit shape index, significantly increase the flowering rates and inflorescence fruit setting rate of following year, while reduce the fruit hardness and soluble solids content, and the effect of microbial fertilizer and compound fertilizer mixed application on increasing fruit weight and yield was higher than that of microbial fertilizer separate application, the effect of the two was not obvious in other aspects. Therefore, microbial fertilizer could be used instead of some chemical fertilizer and organic fertilizer in apple production to reach the aim of increasing yield and efficiency, and the effect of microbial fertilizer and compound fertilizer mixed application was best.展开更多
The seed setting rates of total 198 rice cultivars （lines） at heading and flowering stage were investigated under the condition of extreme natural high tem- perature in 2013 so as to analyze the effect of extreme na...The seed setting rates of total 198 rice cultivars （lines） at heading and flowering stage were investigated under the condition of extreme natural high tem- perature in 2013 so as to analyze the effect of extreme natural high temperature on seed setting rate of different rice cultivar （line）. The results showed that the contin- uous high temperature showed certain effects on the seed setting rates of tested materials, and significant differences were shown in seed setting rate among differ- ent rice cultivars （lines）. The seed setting rates differed significantly among indica F1 hybrids derived from different sterile and restorer lines, indicating that the sterile and restorer lines had great effects on heat tolerances of different F~ hybrids. The cor- relation analysis showed that the seed setting rates of conventional indica restorer lines and conventional japonica rice cultivars （lines） were negatively related to the daily highest temperature （P〉0.05）, and the seed setting rates of indica F1 hybrids were positively related to the seed setting rates of their restorer lines. Total four in- dica restorer lines, including Ninghuiguangkangzhan, Shuhui 527, Chenghui 3203 and Xianyin-8, and four new japonica rice cultivars （lines）, including Wuyinjinghui （B2）, Nanjing 4//W3660/Nanjing 44 （B12） and Wuyun 2330/JD6011 （B22） were pre- liminarily screened, and their seed setting rates were all close to the normal level （90%）. The screened rice cultivars （lines） showed higher heat tolerances.展开更多
Affected by the compressive stress from the South-Central （Indo-China） Peninsula, the Indosinian orogenesis, characterized by collision, thrust and uplifting, took place inside the South China Plate during 250-230 M...Affected by the compressive stress from the South-Central （Indo-China） Peninsula, the Indosinian orogenesis, characterized by collision, thrust and uplifting, took place inside the South China Plate during 250-230 Ma. The ages of the Indosinian granitoids in the Nanling Range and vicinity areas are mostly 240-205 Ma, indicating that they were emplaced in both late collision and post-collision geodynamic environments. No important granite-related metallogenesis occurred in this duration. A post-orogenic setting started at the beginning of the Yanshanian Period, which controlled large-scale granitic magmatism and related metallogenesis. This paper makes the first attempt to divide the Yanshanian Period into three sub-periods, i.e. the early, middle and late Yanshanian Periods, based mainly on the features of magmatism, especially granitoids and related metallogenesis and their geodynamic environments. The magmatic association of the Early Yanshanian （about 185-170 Ma） comprises four categories of magmatism, i.e. basalt, bimodal volcanics, A-type granite and intraplate high-K calc-alkaline （HKCA） magmatism, which indicates an extension-thinning of lithosphere and upwelling of mantle material to a relative small and local extent. Pb-Zn, Cu and Au mineralizations associated with HKCA magmatism represents the first high tide of Mesozoic metallogenesis in the Nanling Range area. During the middle Yanshanian, the lithosphere was subjected to more extensive and intensive extending and thinning, and hence mantle upwelling and basaltic magma underplating caused a great amount of crust remelting granitoids. This period can be further divided into two stages. The first stage （170-150 Ma） is represented by large-scale emplacement of crust remelting granites with local tungsten mineralization at its end. The second stage （150-140 Ma） is the most important time of large-scale mineralizations of non-ferrous and rare metals, e.g. W, Sn, Nb-Ta, Bi, Mo, Be, in the Nanling Range area. The late Yanshanian （140-65 Ma） was generally characterized by full extension and breakup of the lithosphere of South China. However, owing to the influence of the Pacific Plate movement, the eastern part of South China was predominated by subduction-related compression, which resulted in magmatism of calc-alkaline and shoshonite series and related metallogeneses of Au, Ag, Pb-Zn, Cu and （Mo, Sn）, followed by extension in its late stage. In the Nanling Range area, the late Yanshanian magmatism was represented by granitic volcanic-intrusive complexes and mafic dikes, which are genetically related to volcanic-type uranium and porphyry tin deposits, and the mobilization-mineralization of uranium from pre-existing Indosinian granites.展开更多
基金Supported by Traditional Chinese medicine foundation of Zhejiang province:Clinical Study on the Correlation Between Tourette Syndrome and Anatomical Changes in the Atlantoaxial Joint(2010ZB162)Medical Health Science and Technology Project of Zhejiang Provincial Health Commission:Study on Protein Fingerprinting of Tourette Syndrome(2011KYB142)+1 种基金Renowned Traditional Chinese Medicine Expert Inheritance Studio Construction Project of Zhejiang province(No.GZS2020049)Key Disciplines of Traditional Chinese Medicine Foundation of Zhejiang Province(2012-XK-D20)。
文摘OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 into three groups:group A(acupuncture combined with atlantoaxial joint bone setting therapy group),group B(acupuncture group),and group C(tiapride group).After two months of treatment,the Yale global tic severity scale(YGTSS)score reduction,improvement in social function impairment,clinical efficacy,and long-term efficacy in the three groups were compared.RESULTS:After treatment,in the analysis of YGTSS score reduction,social function impairment improvement,the clinical control rate,and long-term efficacy,the results were all Group A>Group B>Group C,with a statistically significant difference(P<0.05).However,the total clinical efficacy of treatment in group A(94.9%)was not significantly different from that in group B(91.8%).Adverse reactions did not occur in groups A and B,and several adverse reactions occurred in 29%(n=58)of the group C patients.CONCLUSION:Compared with traditional drug therapy,acupuncture combined with atlantoaxial joint bone setting therapy has better clinical and long-term efficacy.This treatment strategy can improve the social function of children and prevent adverse reactions to drugs.
基金supported by the National Natural Science Foundation of China(92162218,42302101,42202099)the Guizhou Provincial Natural Science Foundation(ZK[2023]477)。
文摘Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)triangle in the southwestern margin of the Yangtze Block is a globally recognized carbonate-hosted Pb-Zn metallogenic province and also an essential part of the South China low-temperature metallogenic domain.This region has>30 million tons(Mt)Zn and Pb resources and shows the enrichment of dispersed metals,such as Ga,Ge,Cd,Se,and Tl.During the past 2 decades,abundant data on mineralization ages of Pb-Zn deposits within the SYG triangle have been documented based on various radioisotopic dating methods,resulting in significant progress in understanding the geodynamic background and ore formation of Pb-Zn deposits hosted in sedimentary rocks at SYG triangle.This paper provides a comprehensive summary of the geochronological results and Pb-Sr isotopic data regarding Pb-Zn deposits in the SYG triangle,which identified two distinct Pb-Zn mineralization periods influencing the dynamic processes associated with the expansion and closure of the Paleo-Tethys Ocean in the western margin of the Yangtze Block.The predominant phase of Pb-Zn mineralization at SYG triangle spanned from the Middle Triassic to Early Jurassic(226-191 Ma),which was intensely correlated with the large-scale basin fluid transport triggered by the closure of the Paleo-Tethys Ocean and Indosinian orogeny.The secondary Pb-Zn mineralization phase occurred during the Late Devonian to Late Carboniferous and was controlled by extensional structures associated with the expansion of the Paleo-Tethys Ocean.Further investigation is necessary to clarify the occurrence and potential factors involved in the Pb-Zn mineralization events during the Late Devonian to Late Carboniferous.
文摘The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolcanic rocks in the Belts that make up the Birimian Supergroup were intruded by granitoids during the Eburnean Orogeny.This research aims to classify granitoids in the Edikan Mine and ascertain the petrogenetic and geochemical characteristics of some auriferous granitoids in the wider Kumasi Basin,Ghana,to understand the implications for geodynamic settings.A multi-methods approach involving field studies,petrographic studies,and whole-rock geochemical analysis was used to achieve the goal of the study.Petrographic studies revealed a relatively high abundance of plagioclase and a low percentage of K-feldspars(anorthoclase and orthoclase)in the Fobinso samples,suggesting that the samples are granodioritic in nature,while the Esuajah samples showed relatively low plagioclase abundance and a high percentage in K-feldspars,indicating that they are granitic.The granitoids from the study areas are co-magmatic.The granitoids in Esuajah and Fobinso are generally enriched in large ion lithophile elements and light rare earth elements than high field strength elements,middle rare earth elements,and heavy rare earth elements,indicating mixing with crustal sources during the evolution of the granitoids.The granitoids were tectonically formed in a syn-collisional+VAG setting,which implies that they were formed in the subduction zone setting.Fobinso granodiorites showed S-type signatures with evidence of extensive crustal contamination,while the Esuajah granites showed I-type signatures with little or no crustal contamination and are peraluminous.Gold mineralization in the study area is structurally and lithologically controlled with shear zones,faulting,and veining as the principal structures controlling the mineralization.The late-stage vein,V3,in the Edikan Mine is characterized by a low vein angle and is mineralized.
基金This retrospective analysis incorporated data from two clinical trials(CTR20220854 and CTR20222843)sponsored by Chongqing Chenan Biopharmaceutical Co.,Ltd.and Jiangsu Hengrui Pharmaceuticals Co.,Ltd.However,these sponsors did not partake in the study design,data interpretation,or manuscript preparation.
文摘BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques before entry into the market.Typically,blood glucose(BG)levels are maintained at 5%below baseline to suppress endogenous insulin secretion in healthy volunteers.However,in scenarios where BG baseline is relatively low,maintaining it at 5%below baseline can increase hypoglycemic risk.Consequently,we adjusted to maintain it at 2.5%below a baseline of<4.00 mmol/L.It remains uncertain whether this adjustment impacts endogenous insulin inhibition or the PD of study insulin.AIM To evaluate and compare the PD and C-peptide status using two different target BG setting methods.METHODS Data came from euglycemic clamp trials assessing the PK/PD of insulin aspart(IAsp)in healthy participants.Target BG was set at 2.5%below baseline for those with a basal BG of<4.00 mmol/L(group A),and at 5%below baseline for others(group B).The area under the curve(AUC)of IAsp(AUC_(IAsp,0-8 h))and GIR from 0 to 8 hours(AUCGIR,0-8 h)was used to characterize the PK and PD of IAsp,respectively.The C-peptide reduction and PK/PD of IAsp were compared between the two groups.RESULTS Out of 135 subjects,15 were assigned to group A and 120 to group B;however,group B exhibited higher basal Cpeptide(1.59±0.36 vs 1.32±0.42 ng/mL,P=0.006).Following propensity score matching to adjust for basal Cpeptide differences,71 subjects(15 in group A and 56 in group B)were analyzed.No significant differences were observed in demographics,IAsp dosage,or clamp quality.Group B showed significantly higher baseline(4.35±0.21 vs 3.91±0.09 mmol/L,P<0.001),target(4.13±0.20 vs 3.81±0.08 mmol/L,P<0.001),and clamped(4.10±0.17 vs 3.80±0.06 mmol/L,P<0.001)BG levels.Both groups exhibited comparable C-peptide suppression(32.5%±10.0%vs 35.6%±12.1%,P=0.370)and similar IAsp activity(AUCGIR,0-8 h:1433±400 vs 1440±397 mg/kg,P=0.952)under nearly equivalent IAsp exposure(AUC_(IAsp,0-8 h):566±51 vs 571±85 ng/mL×h,P=0.840).CONCLUSION Maintaining BG at 2.5%below a baseline of<4.00 mmol/L did not compromise the endogenous insulin suppression nor alter the observed pharmacodynamic effects of the study insulin.
基金the financial support for this research provided by the National Natural Science Foundation of China(Grant Nos.52275470,124115301,and 52105458)the Natural Science Foundation of Beijing(Grant No.3222009).
文摘Vibration cutting has emerged as a promising method for creating surface functional microstructures.However,achieving precise tool setting is a time-consuming process that significantly impacts process efficiency.This study proposes an intelligent approach for tool setting in vibration cutting using machine vision and hearing,divided into two steps.In the first step,machine vision is employed to achieve rough precision in tool setting within tens of micrometers.Subsequently,in the second step,machine hearing utilizes sound pickup to capture vibration audio signals,enabling fine tool adjustment within 1μm precision.The relationship between the spectral intensity of vibration audio and cutting depth is analyzed to establish criteria for tool–workpiece contact.Finally,the efficacy of this approach is validated on an ultra-precision platform,demonstrating that the automated tool-setting process takes no more than 74 s.The total cost of the vision and hearing sensors is less than$1500.
文摘Point-of-care ultrasound(POCUS) is recognized as a valuable diagnostic tool,especially in resourcelimited settings(RLS).POCUS provides rapid diagnostic information that enables health professionals to make critical decisions at the bedside.^([1]) Despite the welldocumented benefits of POCUS,access to longitudinal,comprehensive training programs and a lack of trainee feedback are barriers to the widespread use of this technology in such settings.^([2])
文摘Breast cancer is the leading cause of cancer-related mortality in women globally,with its incidence continuing to rise,particularly in low-and middle-income countries,presenting a significant public health challenge worldwide[1].According to data from the Institute for Health Metrics and Evaluation(IHME)and the World Health Organization(WHO),the gap in access to healthcare services between high-and low-income countries contributes to delayed detection,increased incidence of advanced-stage disease,and,consequently,higher mortality rates(up to 50%higher compared to high-income countries)[1,2].This translates into inequalities in access to screening and early diagnosis methods,which exacerbate the burden of this disease in low-resource settings where infrastructure,funding,and access to trained professionals are limited[3].
基金supported by Jiangsu Provincial Key Research and Development Program(No.BE2023014-4).
文摘During the automated placement process of dry fibers,the positioning and fixation of dry fiber gauze belts are achieved by spraying setting agents.The amount of the setting agent is difficult to control when it is sprayed manually.Furthermore,it can also affect the permeability of the preform,resin injection and the quality of the vacuum assisted resin infusion(VARI)molding,resulting in a decrease in the mechanical properties of composite materials.This study utilizes dry fiber automated placement equipment and an automated spraying system to manufacture preform structures,followed by VARI process to prepare composite samples with varying setting agent contents.Subsequently,mechanical characterization including interlaminar shear,bending and tensile testing is conducted to investigate the influence of setting agent content on both the manufacturing process and the mechanical properties of composite products.The results show that the interlaminar shear strength,bending strength and tensile strength of the sample gradually decrease with the increase of the content of the setting agent.The optimal setting agent content for automated laying of dry fiber is determined to be 4%-6%,balancing the preformed body’s layup quality and its impact on mechanical properties.Compared with agent-free samples,this range results in reductions of 3% in interlaminar shear strength,9% in bending strength,11% in bending modulus,and 13%-16% in tensile strength.
基金Dr.Stergios D.Zarkogiannis would like to acknowledge UK Research and Innovation Grant(SODIOM)EP/Y004221/1 in supporting the research reported here.
文摘This study investigates the facies development and sedimentology of the Late Permian Chhidru Formation,a mixed carbonate-siliciclastic unit exposed in the Western Salt Range,Potwar Basin,Pakistan.The formation is subdivided into four lithological units reflecting lateral variability,with thicknesses and lithologies ranging from fossiliferous sandy limestone to interbedded limestone and sandstone.These successions record a depositional shift from a carbonate platform to mixed carbonate-clastic,and ultimately,clastic-dominated environments.Lithostratigraphy suggests deposition on the underlying Wargal Limestone carbonates during a Late Permian sea-level fall on the northwest Indian margin of Gondwana.Similar Permian successions with identical lithological characteristics are documented in the Persian Gulf(Dalan Formation),Arabian Platform(Khuff Formation),and Iran(Nesen and Hambust formations).Petrographic analysis reveals deposition in the distal middle to proximal inner shelf settings of a carbonate-siliciclastic mixed,unrimmed platform.Based on identified foraminiferal assemblages,the Chhidru Formation's age is estimated to range from the late Wuchiapingian to Changhsingian stages of the Lopingian epoch.
文摘Circumlunar abort trajectories constitute a vital contingency return strategy during the translunar phase of crewed lunar missions.This paper proposes a methodology for constructing the solution set of the circumlunar abort trajectory and leverages its advantageous properties to address the optimization design problem of abort trajectories.Initially,a solution set of all feasible abort trajectories,originating from an abort point on the nominal trajectory and complying with fundamental reentry constraints,is formulated through the introduction of two novel design parameters.Subsequently,the geometric characteristics of the solution set,as well as the distributional properties of key iterative constraint responses,including flight time and velocity increment,are analyzed.Finally,the characteristics exhibited in the solution set are employed to directly identify the design parameters of the abort trajectories with minimum flight time and velocity increment,thereby providing solutions to two distinct types of optimization problems.The simulation results for a variety of nominal trajectories,encompassing the reconstruction and redesign of the Apollo13 abort trajectory,validate the proposed method,demonstrating its ability to directly generate optimal abort trajectories.The method proposed in this paper investigates feasible abort trajectories from a global perspective,providing both a framework and convenience for mission planning and iterative optimization in abort trajectory design.
文摘[Objectives]To provide a reference for the efficient use of wild Paeonia suffruticosa germplasm resources and the scientific selection of parents.[Methods]This study systematically evaluated cross-compatibility by conducting interspecific crosses among the major wild species subsect.Delavayanae(Paeonia delavayi,Paeonia lutea,Paeonia potaninii,and Paeonia ludlowii)as well as reciprocal crosses between these species and cultivated varieties from the subsect.Vaginatae.[Results]Crosses among P.delavayi,P.lutea,and P.potaninii generally exhibited good seed set,with the resulting seeds showing a high emergence rate.In contrast,crosses involving P.ludlowii as a parent produced only a limited number of seeds,none of which germinated.In crosses with cultivated varieties where the wild species served as the maternal parent,the average seed set ranked as follows:P.lutea>P.delavayi>P.ludlowii>P.potaninii.When wild species were used as paternal parent,the average seed set ranked as follows:P.potaninii>P.lutea>P.delavayi>P.ludlowii.On the whole,most crosses between wild species of subsect.Delavayanae and cultivated varieties achieved normal seed set,demonstrating a certain degree of cross-compatibility.However,when the wild species served as the maternal parent,both the seed set and seedling emergence rate were superior to those in the reciprocal crosses(with wild species as the paternal parent).[Conclusions]Significant differences in cross-compatibility were observed among species within Paeonia subsect.Delavayanae.In addition,a significant maternal effect was identified in crosses between wild species of this subsection and cultivated varieties.These findings suggest that by selecting highly compatible combinations,there remains considerable potential for utilizing these wild species in peony breeding.
文摘Deep learning attentionmechanisms have achieved remarkable progress in computer vision,but still face limitations when handling images with ambiguous boundaries and uncertain feature representations.Conventional attention modules such as SE-Net,CBAM,ECA-Net,and CA adopt a deterministic paradigm,assigning fixed scalar weights to features without modeling ambiguity or confidence.To overcome these limitations,this paper proposes the Fuzzy Attention Network Layer(FANL),which integrates intuitionistic fuzzy set theory with convolutional neural networks to explicitly represent feature uncertainty through membership(μ),non-membership(ν),and hesitation(π)degrees.FANLconsists of four coremodules:(1)feature dimensionality reduction via global pooling,(2)fuzzymodeling using learnable clustering centers,(3)adaptive attention generation through weighted fusion of fuzzy components,and(4)feature refinement through residual connections.A cross-layer guidance mechanism is further introduced to enhance hierarchical feature propagation,allowing high-level semantic features to incorporate fine-grained texture information from shallow layers.Comprehensive experiments on three benchmark datasets—PathMNIST-30000,full PathMNIST,and Blood MNIST—demonstrate the effectiveness and generalizability of FANL.The model achieves 84.41±0.56%accuracy and a 1.69%improvement over the baseline CNN while maintaining lightweight computational complexity.Ablation studies show that removing any component causes a 1.7%–2.0%performance drop,validating the synergistic contribution of each module.Furthermore,FANL provides superior uncertainty calibration(ECE=0.0452)and interpretable selective prediction under uncertainty.Overall,FANL presents an efficient and uncertaintyaware attention framework that improves both accuracy and reliability,offering a promising direction for robust visual recognition under ambiguous or noisy conditions.
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.
基金supported by the National Natural Science Foundation(42472325)the Fundamental Research Funds of Chinese Academy of Geological Science(SK202103).
文摘To elucidate the geographical differentiation characteristics and driving mechanisms of Dissolved Organic Matter(DOM)in typical rivers,this study conducted a multi-spectral investigation on three representative river types within Shandong Province:The mountainous Dawen River,the plain Tuhai River,and the artificial East Grand Canal.The DOM composition was analyzed using Ultraviolet-Visible(UV-Vis)absorption spectroscopy,Excitation-Emission Matrix(EEM)fluorescence spectroscopy,and parallel factor analysis(PARAFAC),while Principal Component Analysis(PCA)was employed to quantify the synergistic effects of natural processes and anthropogenic activities.Results revealed significant spatial heterogeneity in DOM composition and sources.The plain river exhibited the highest aromaticity(humic-like components:43.3%)due to long-term agricultural non-point source inputs and urban wastewater discharge.The mountain stream,shaped by complex terrain and relatively intact ecosystems,was dominated by autochthonous DOM derived from microbial metabolism,with higher Fluorescence Index(FI=2.12)and biological index(BIX=1.35)than other river types.The artificial canal retained protein-like components(64.2%),largely attributed to winter hydrological stagnation and disturbances from shipping activities.Further analysis demonstrated that geographical settings(e.g.,mountain terrain)and anthropogenic activities(e.g.,agriculture,shipping)jointly regulated DOM composition by altering the balance between input and transformation processes.Integrated fluorescence parameters and PCA results suggested differentiated management strategies:protecting ecological integrity in mountain streams to sustain selfpurification,enhancing non-point source interception in plain rivers,and mitigating shipping pollution in canals.This study systematically reveals the natural-anthropogenic coupling mechanisms driving DOM dynamics in northern China rivers,providing critical insights for precision water environment management at the watershed scale.
文摘The quality of cardiopulmonary resuscitation(CPR) significantly influences survival and neurological outcomes in patients with cardiac arrest(CA).Although mechanical chest compression devices and extracorporeal cardiopulmonary resuscitation(ECPR) have demonstrated some benefits,high-quality manual CPR remained the essential first step,particularly in resource-limited settings.In this study,we examined whether opportunities existed to improve manual CPR performance using preliminary data from our recent survey conducted in a province in western China.We aim to emphasize the importance of improving manual CPR quality before implementing advanced interventions.
基金The Central Government Guides Local Foundation for Science and Technology Development(Grant No.YDZJSX2024B004).
文摘The soft actuator is characterized by high safety,flexibility,and adaptability.It is capable of both active and passive defor-mations.This paper presents a discrete degree of freedom(DOF)method for soft actuators to reveal DOF characteristics.The method draws on the superposition mechanism of the deformation characteristics of the sarcomere in the skeletal muscles of living organisms.Firstly,the multi-DOF deformation characteristics of the soft actuator are discretized into superimposed combinations of single-DOF micro-units.Then,the soft actuator was determined to contain deformation characteristics such as extension-contraction,bending,and twisting.Eighteen types of micro-units with basic deforma-tion characteristics were obtained depending on the axis and orientation.Further,the mapping relationship between the combination of micro-units and the motion characteristics of the soft actuator based on the GF set theory was established.Finally,an active-passive DOF co-structured soft actuator(APCSA)was developed.The graphical approach analyzes the experimental results,and it can be concluded that active and passive DOFs can coexist in the composite deformation of the soft actuator.
基金supported by the National Natural Science Foundation of China(62073267,61903305)the Fundamental Research Funds for the Central Universities(HXGJXM202214)。
文摘For mission-oriented unmanned aerial vehicle(UAV)swarms,mission capability assessment provides an important reference in the design and development process,and is a precondition for mission success.For this multi-criteria decisionmaking(MCDM)problem,the current literature lacks a way to unambiguously present criteria and the popular fuzzy analytic network process(ANP)approaches neglect the hesitancy of subjective judgments.To fill these research gaps,an MCDM method based on unified architecture framework(UAF)and interval-valued spherical fuzzy ANP(IVSF-ANP)is proposed in this paper.Firstly,selected viewpoints in UAF are extended to construct criteria models with standardized representation.Secondly,interval-valued spherical fuzzy sets are introduced to ANP to weight interdependent criteria,handling fuzziness and hesitancy in pairwise comparisons.A method of adjusting weights of experts based on their decision similarities is also included in this process to reduce ambiguity brought by multiple experts.Next,performance characteristics are non-linearly transformed regarding to expectations to get final results.This proposition is applied to assess the mission capability of UAV swarms to search and strike surface vessels.Comparative analysis shows that the proposed method is valid and reasonable.
基金Supported by Special Fund for Agro-scientific Research in the Public Interest(201303133-1-4)The Doctoral Program of Hebei Academy of Agriculture and Forestry Sciences~~
文摘In order to study the application effect of microbial fertilizer and compound fertilizer mixed application on microirrigation apple, three types of fertilizers were applied in spring which were urea（CK, 15 kg/plant）, microbial fertilizer（5.0 kg/plant）,microbial fertilizer and compound fertilizer mixed（each 2.5 kg/plant） to study the effect of different fertilizer treatments on yield, fruit quality, flowering and fruit setting of Xinshijie apple. The results showed that application of microbial fertilizer could increase the yield, fruit weight and fruit shape index, significantly increase the flowering rates and inflorescence fruit setting rate of following year, while reduce the fruit hardness and soluble solids content, and the effect of microbial fertilizer and compound fertilizer mixed application on increasing fruit weight and yield was higher than that of microbial fertilizer separate application, the effect of the two was not obvious in other aspects. Therefore, microbial fertilizer could be used instead of some chemical fertilizer and organic fertilizer in apple production to reach the aim of increasing yield and efficiency, and the effect of microbial fertilizer and compound fertilizer mixed application was best.
基金Supported by National Natural Science Foundation of China(31201181)Earmarked Fund for China Agriculture Research System(CARS-01-47)Project for Breeding and Demonstration of New Super Rice Varieties~~
文摘The seed setting rates of total 198 rice cultivars （lines） at heading and flowering stage were investigated under the condition of extreme natural high tem- perature in 2013 so as to analyze the effect of extreme natural high temperature on seed setting rate of different rice cultivar （line）. The results showed that the contin- uous high temperature showed certain effects on the seed setting rates of tested materials, and significant differences were shown in seed setting rate among differ- ent rice cultivars （lines）. The seed setting rates differed significantly among indica F1 hybrids derived from different sterile and restorer lines, indicating that the sterile and restorer lines had great effects on heat tolerances of different F~ hybrids. The cor- relation analysis showed that the seed setting rates of conventional indica restorer lines and conventional japonica rice cultivars （lines） were negatively related to the daily highest temperature （P〉0.05）, and the seed setting rates of indica F1 hybrids were positively related to the seed setting rates of their restorer lines. Total four in- dica restorer lines, including Ninghuiguangkangzhan, Shuhui 527, Chenghui 3203 and Xianyin-8, and four new japonica rice cultivars （lines）, including Wuyinjinghui （B2）, Nanjing 4//W3660/Nanjing 44 （B12） and Wuyun 2330/JD6011 （B22） were pre- liminarily screened, and their seed setting rates were all close to the normal level （90%）. The screened rice cultivars （lines） showed higher heat tolerances.
基金The present study is supported by the State Key Fundamental Research Project(Grant No.G1999043209)National Natural Science Foundation of China(Grant No.40132010).
文摘Affected by the compressive stress from the South-Central （Indo-China） Peninsula, the Indosinian orogenesis, characterized by collision, thrust and uplifting, took place inside the South China Plate during 250-230 Ma. The ages of the Indosinian granitoids in the Nanling Range and vicinity areas are mostly 240-205 Ma, indicating that they were emplaced in both late collision and post-collision geodynamic environments. No important granite-related metallogenesis occurred in this duration. A post-orogenic setting started at the beginning of the Yanshanian Period, which controlled large-scale granitic magmatism and related metallogenesis. This paper makes the first attempt to divide the Yanshanian Period into three sub-periods, i.e. the early, middle and late Yanshanian Periods, based mainly on the features of magmatism, especially granitoids and related metallogenesis and their geodynamic environments. The magmatic association of the Early Yanshanian （about 185-170 Ma） comprises four categories of magmatism, i.e. basalt, bimodal volcanics, A-type granite and intraplate high-K calc-alkaline （HKCA） magmatism, which indicates an extension-thinning of lithosphere and upwelling of mantle material to a relative small and local extent. Pb-Zn, Cu and Au mineralizations associated with HKCA magmatism represents the first high tide of Mesozoic metallogenesis in the Nanling Range area. During the middle Yanshanian, the lithosphere was subjected to more extensive and intensive extending and thinning, and hence mantle upwelling and basaltic magma underplating caused a great amount of crust remelting granitoids. This period can be further divided into two stages. The first stage （170-150 Ma） is represented by large-scale emplacement of crust remelting granites with local tungsten mineralization at its end. The second stage （150-140 Ma） is the most important time of large-scale mineralizations of non-ferrous and rare metals, e.g. W, Sn, Nb-Ta, Bi, Mo, Be, in the Nanling Range area. The late Yanshanian （140-65 Ma） was generally characterized by full extension and breakup of the lithosphere of South China. However, owing to the influence of the Pacific Plate movement, the eastern part of South China was predominated by subduction-related compression, which resulted in magmatism of calc-alkaline and shoshonite series and related metallogeneses of Au, Ag, Pb-Zn, Cu and （Mo, Sn）, followed by extension in its late stage. In the Nanling Range area, the late Yanshanian magmatism was represented by granitic volcanic-intrusive complexes and mafic dikes, which are genetically related to volcanic-type uranium and porphyry tin deposits, and the mobilization-mineralization of uranium from pre-existing Indosinian granites.
