On-machine tool setting is a pivotal approach in achieving intelligent manufacturing,and laser tool setters have become a crucial component of smart machine tools.Laser tool setters play a crucial role in precisely me...On-machine tool setting is a pivotal approach in achieving intelligent manufacturing,and laser tool setters have become a crucial component of smart machine tools.Laser tool setters play a crucial role in precisely measuring the dimensions of cutting tools during the part machining process,focusing on tool length and diameter.As a measuring instrument,the positions of the laser axis of the laser tool setter need to be accurately calibrated before use.However,in actual calibration scenarios,traditional calibration methods face challenges due to installation errors in the tool setter and geometric errors in the measuring rod.To address this issue,this study proposes a novel calibration method.Initially,the calibration mechanism of the laser beam axis is established.Based on the accurate mathematical model of the laser beam and the measuring rod,and using the polygon clipping algorithm,the mathematical mechanism of the laser tool setter’s work is established.Then,a novel method is introduced to calculate the compensation distance between the laser beam reference point and the rod bottom center point at each moment during calibration.Furthermore,by utilizing the kinematic chain of the tool setter calibration system,a new calibration method is developed to accurately calibrate the position of the laser beam axis in the machine tool coordinate system.Finally,the accuracy of the calibration method is verified through simulation experiments and calibration tests.This method improves the calibration accuracy of the tool setter,and the mathematical model of the laser tool setter can be extended to the measurement of tools,thereby improving the precision of tool measurements.This research significantly improves the efficient production performance of smart machine tools.展开更多
Objective To investigate the effects of rapamycin on cholesterol homeostasis of glomerular mesangial cells and the underlying mechanisms. Methods Intracellular cholesterol accumulation was measured by Oil Red O stain...Objective To investigate the effects of rapamycin on cholesterol homeostasis of glomerular mesangial cells and the underlying mechanisms. Methods Intracellular cholesterol accumulation was measured by Oil Red O staining and high performance liquid chromatography. The effects of rapamycin on interleukin-1β（1L-1β）-induced mRNA and protein changes of low-density lipoprotein receptor （LDLR） and ATP-binding cassette transporter Al （ABCAl） were assayed by quantitative real-time PCR and Western blot. Transient expressions of 3 types of mammalian target of rapamycin （mTOR）, including mTOR-WT （wild type）, mTOR-RR （rapamycin resistant, with kinase activity）, and mTOR-RR-KD （rapamycin resistant, without kinase activity）, were obtained by plasmid transfection. Results Rapamycin had no significant influence on intracellular cholesterol concentration trader normal condition, but it significantly decreased the intracellular cholesterol concentration in the presence of IL-1β. Rapamycin dose-dependently suppressed the increased expression of LDLR induced by IL-1β and up-regulated the suppressed expression of ABCAl caused by IL-1β Transient expression of 3 types of mTOR all reduced ABCAl mRNA expression significantly, which all could be overroded by rapamycin. Conclusions Rapamycin may contribute to the maintaining of glomerular mesangial cell intracellular cholesterol homeostasis under inflammatory state by both reducing cholesterol uptake and increasing cholesterol effiux. And the effect may be not completely mediiated by mTOR.展开更多
Solid-liquid separation of the wastewater is very difficult because of high viscosity and high SS concentration. In this study, the effectiveness of preozonation on improving the settleability of the solids in wheat a...Solid-liquid separation of the wastewater is very difficult because of high viscosity and high SS concentration. In this study, the effectiveness of preozonation on improving the settleability of the solids in wheat and sweet potato wastewaters was investigated using a bench-scale system and pilot treatment system respectively. Results showed that solid-liquid separation in the wheat wastewater was greatly improved by the decanter in the system(SS reduction from 24100 mg/L to 100 mg/L). However, preozonation practice did not show a significant effect on solid-liquid separation of the sweet potato wastewater. Effect of preozonation on solid-liquid separation between wheat and sweet potato wastewater showed different.展开更多
In the attempt to evaluate the quality of teacher talk,recent communicative approaches have suggested that the modification of teacher classroom speech and the functional distribution of teacher talk in terms of pedag...In the attempt to evaluate the quality of teacher talk,recent communicative approaches have suggested that the modification of teacher classroom speech and the functional distribution of teacher talk in terms of pedagogical goals should be considered(Seedhouse:1996).This study investigates the relationship between language use and pedagogic purpose from an analysis of a lesson transcript of a grammar lesson,and evaluates the quality of the teacher talk based on the Self-Evaluation of Teacher Talk(SETT)Grid.The purpose is to examine whether the teacher talk is appropriate in the classroom context or mode and to bring about a more conscious and effective use of teacher talk in her teaching profession in the future.展开更多
在外语教学中,教师话语不仅是传授知识和管理课堂的媒介,也是学生可理解性输入的重要来源。英国学者 Steve Walsh 提出的教师话语自我评价(Self-Evaluation of Teacher Talk,SETT)框架为教师话语的研究提供了一种新方法。本文在回顾 SE...在外语教学中,教师话语不仅是传授知识和管理课堂的媒介,也是学生可理解性输入的重要来源。英国学者 Steve Walsh 提出的教师话语自我评价(Self-Evaluation of Teacher Talk,SETT)框架为教师话语的研究提供了一种新方法。本文在回顾 SETT 框架相关理论的基础上,对以 SETT框架作为研究对象或研究工具的文献进行综述,分析和探讨该框架对于研究外语教师课堂话语的意义。展开更多
文摘On-machine tool setting is a pivotal approach in achieving intelligent manufacturing,and laser tool setters have become a crucial component of smart machine tools.Laser tool setters play a crucial role in precisely measuring the dimensions of cutting tools during the part machining process,focusing on tool length and diameter.As a measuring instrument,the positions of the laser axis of the laser tool setter need to be accurately calibrated before use.However,in actual calibration scenarios,traditional calibration methods face challenges due to installation errors in the tool setter and geometric errors in the measuring rod.To address this issue,this study proposes a novel calibration method.Initially,the calibration mechanism of the laser beam axis is established.Based on the accurate mathematical model of the laser beam and the measuring rod,and using the polygon clipping algorithm,the mathematical mechanism of the laser tool setter’s work is established.Then,a novel method is introduced to calculate the compensation distance between the laser beam reference point and the rod bottom center point at each moment during calibration.Furthermore,by utilizing the kinematic chain of the tool setter calibration system,a new calibration method is developed to accurately calibrate the position of the laser beam axis in the machine tool coordinate system.Finally,the accuracy of the calibration method is verified through simulation experiments and calibration tests.This method improves the calibration accuracy of the tool setter,and the mathematical model of the laser tool setter can be extended to the measurement of tools,thereby improving the precision of tool measurements.This research significantly improves the efficient production performance of smart machine tools.
文摘Objective To investigate the effects of rapamycin on cholesterol homeostasis of glomerular mesangial cells and the underlying mechanisms. Methods Intracellular cholesterol accumulation was measured by Oil Red O staining and high performance liquid chromatography. The effects of rapamycin on interleukin-1β（1L-1β）-induced mRNA and protein changes of low-density lipoprotein receptor （LDLR） and ATP-binding cassette transporter Al （ABCAl） were assayed by quantitative real-time PCR and Western blot. Transient expressions of 3 types of mammalian target of rapamycin （mTOR）, including mTOR-WT （wild type）, mTOR-RR （rapamycin resistant, with kinase activity）, and mTOR-RR-KD （rapamycin resistant, without kinase activity）, were obtained by plasmid transfection. Results Rapamycin had no significant influence on intracellular cholesterol concentration trader normal condition, but it significantly decreased the intracellular cholesterol concentration in the presence of IL-1β. Rapamycin dose-dependently suppressed the increased expression of LDLR induced by IL-1β and up-regulated the suppressed expression of ABCAl caused by IL-1β Transient expression of 3 types of mTOR all reduced ABCAl mRNA expression significantly, which all could be overroded by rapamycin. Conclusions Rapamycin may contribute to the maintaining of glomerular mesangial cell intracellular cholesterol homeostasis under inflammatory state by both reducing cholesterol uptake and increasing cholesterol effiux. And the effect may be not completely mediiated by mTOR.
文摘Solid-liquid separation of the wastewater is very difficult because of high viscosity and high SS concentration. In this study, the effectiveness of preozonation on improving the settleability of the solids in wheat and sweet potato wastewaters was investigated using a bench-scale system and pilot treatment system respectively. Results showed that solid-liquid separation in the wheat wastewater was greatly improved by the decanter in the system(SS reduction from 24100 mg/L to 100 mg/L). However, preozonation practice did not show a significant effect on solid-liquid separation of the sweet potato wastewater. Effect of preozonation on solid-liquid separation between wheat and sweet potato wastewater showed different.
文摘In the attempt to evaluate the quality of teacher talk,recent communicative approaches have suggested that the modification of teacher classroom speech and the functional distribution of teacher talk in terms of pedagogical goals should be considered(Seedhouse:1996).This study investigates the relationship between language use and pedagogic purpose from an analysis of a lesson transcript of a grammar lesson,and evaluates the quality of the teacher talk based on the Self-Evaluation of Teacher Talk(SETT)Grid.The purpose is to examine whether the teacher talk is appropriate in the classroom context or mode and to bring about a more conscious and effective use of teacher talk in her teaching profession in the future.
文摘在外语教学中,教师话语不仅是传授知识和管理课堂的媒介,也是学生可理解性输入的重要来源。英国学者 Steve Walsh 提出的教师话语自我评价(Self-Evaluation of Teacher Talk,SETT)框架为教师话语的研究提供了一种新方法。本文在回顾 SETT 框架相关理论的基础上,对以 SETT框架作为研究对象或研究工具的文献进行综述,分析和探讨该框架对于研究外语教师课堂话语的意义。
