The sustainability of the Internet of Things(IoT)involves various issues,such as poor connectivity,scalability problems,interoperability issues,and energy inefficiency.Although the Sixth Generation of mobile networks(...The sustainability of the Internet of Things(IoT)involves various issues,such as poor connectivity,scalability problems,interoperability issues,and energy inefficiency.Although the Sixth Generation of mobile networks(6G)allows for Ultra-Reliable Low-Latency Communication(URLLC),enhanced Mobile Broadband(eMBB),and massive Machine-Type Communications(mMTC)services,it faces deployment challenges such as the short range of sub-THz and THz frequency bands,low capability to penetrate obstacles,and very high path loss.This paper presents a network architecture to enhance the connectivity of wireless IoT mesh networks that employ both 6G and Wi-Fi technologies.In this architecture,local communications are carried through the mesh network,which uses a virtual backbone to relay packets to local nodes,while remote communications are carried through the 6G network.The virtual backbone is created using a heuristic distributed ConnectedDominating Set(CDS)algorithm.In this algorithm,each node uses information collected from its one-and two-hop neighbors to determine its role and find the set of expansion nodes that are used to select the next CDS nodes.The proposed algorithm has O(n)message and O(K)time complexities,where n is the number of nodes in the network,and K is the depth of the cluster.The study proved that the approximation ratio of the algorithmhas an upper bound of 2.06748(3.4306MCDS+4.8185).Performance evaluations compared the size of the CDS against the theoretical limit and recent CDS clustering algorithms.Results indicate that the proposed algorithm has the smallest average slope for the size of the CDS as the number of nodes increases.展开更多
Submodular optimization is primarily applied in multi-agent systems for tasks such as resource allocation,task assignment,collaborative decision-making,and optimization problems.Maximization of optimizing submodular s...Submodular optimization is primarily applied in multi-agent systems for tasks such as resource allocation,task assignment,collaborative decision-making,and optimization problems.Maximization of optimizing submodular set functions attracts much attention since the 1970s.A large body of work has been done using approximation algorithms.When the dimension of the independent variable of the set function changes from one tok,it is called ak-submodular set function.Thek-submodular set function,a generalization of the classical submodular set function,arises in diverse fields with varied applications.In many practical scenarios,quantifying the degree of closeness to submodularity becomes essential,leading to concepts such as approximately submodular set functions and the diminishing-return(DR) ratio.This paper investigates ak-dimensional set function under matroid constraints,which may lack full submodularity.Instead,we focus on an approximately non-ksubmodular set function characterized by its DR ratio.Employing a greedy algorithmic approach,we derive an approximation guarantee for this problem.Notably,when the DR ratio is set to one,our results align with existing findings in the literature.Experimental results demonstrate the superiority of our algorithm over the baselines.展开更多
Deep learning attentionmechanisms have achieved remarkable progress in computer vision,but still face limitations when handling images with ambiguous boundaries and uncertain feature representations.Conventional atten...Deep learning attentionmechanisms have achieved remarkable progress in computer vision,but still face limitations when handling images with ambiguous boundaries and uncertain feature representations.Conventional attention modules such as SE-Net,CBAM,ECA-Net,and CA adopt a deterministic paradigm,assigning fixed scalar weights to features without modeling ambiguity or confidence.To overcome these limitations,this paper proposes the Fuzzy Attention Network Layer(FANL),which integrates intuitionistic fuzzy set theory with convolutional neural networks to explicitly represent feature uncertainty through membership(μ),non-membership(ν),and hesitation(π)degrees.FANLconsists of four coremodules:(1)feature dimensionality reduction via global pooling,(2)fuzzymodeling using learnable clustering centers,(3)adaptive attention generation through weighted fusion of fuzzy components,and(4)feature refinement through residual connections.A cross-layer guidance mechanism is further introduced to enhance hierarchical feature propagation,allowing high-level semantic features to incorporate fine-grained texture information from shallow layers.Comprehensive experiments on three benchmark datasets—PathMNIST-30000,full PathMNIST,and Blood MNIST—demonstrate the effectiveness and generalizability of FANL.The model achieves 84.41±0.56%accuracy and a 1.69%improvement over the baseline CNN while maintaining lightweight computational complexity.Ablation studies show that removing any component causes a 1.7%–2.0%performance drop,validating the synergistic contribution of each module.Furthermore,FANL provides superior uncertainty calibration(ECE=0.0452)and interpretable selective prediction under uncertainty.Overall,FANL presents an efficient and uncertaintyaware attention framework that improves both accuracy and reliability,offering a promising direction for robust visual recognition under ambiguous or noisy conditions.展开更多
Circumlunar abort trajectories constitute a vital contingency return strategy during the translunar phase of crewed lunar missions.This paper proposes a methodology for constructing the solution set of the circumlunar...Circumlunar abort trajectories constitute a vital contingency return strategy during the translunar phase of crewed lunar missions.This paper proposes a methodology for constructing the solution set of the circumlunar abort trajectory and leverages its advantageous properties to address the optimization design problem of abort trajectories.Initially,a solution set of all feasible abort trajectories,originating from an abort point on the nominal trajectory and complying with fundamental reentry constraints,is formulated through the introduction of two novel design parameters.Subsequently,the geometric characteristics of the solution set,as well as the distributional properties of key iterative constraint responses,including flight time and velocity increment,are analyzed.Finally,the characteristics exhibited in the solution set are employed to directly identify the design parameters of the abort trajectories with minimum flight time and velocity increment,thereby providing solutions to two distinct types of optimization problems.The simulation results for a variety of nominal trajectories,encompassing the reconstruction and redesign of the Apollo13 abort trajectory,validate the proposed method,demonstrating its ability to directly generate optimal abort trajectories.The method proposed in this paper investigates feasible abort trajectories from a global perspective,providing both a framework and convenience for mission planning and iterative optimization in abort trajectory design.展开更多
A discrete subset S of a topological gyrogroup G with the identity 0 is said to be a suitable set for G if it generates a dense subgyrogroup of G and S∪{0}is closed in G.In this paper,it is proved that each countable...A discrete subset S of a topological gyrogroup G with the identity 0 is said to be a suitable set for G if it generates a dense subgyrogroup of G and S∪{0}is closed in G.In this paper,it is proved that each countable Hausdorff topological gyrogroup has a suitable set;moreover,it is shown that each separable metrizable strongly topological gyrogroup has a suitable set.展开更多
Objectives:Tamoxifen is a key drug that provides endocrine therapy for estrogen receptor(ER)α-positive breast cancer;however,resistance remains a significant clinical challenge.This study aims to investigate the mole...Objectives:Tamoxifen is a key drug that provides endocrine therapy for estrogen receptor(ER)α-positive breast cancer;however,resistance remains a significant clinical challenge.This study aims to investigate the molecular mechanisms of tamoxifen resistance in ERα-positive breast cancer,with particular focus on the role of SET Domain Containing 1A(SETD1A)-driven forkhead box A2(FOXA2)as a key regulator of this resistance.Methods:FOXA2 expression and its regulation by SETD1A were assessed via(quantitative polymerase chain reaction),western blotting,transcriptome profiling,and chromatin immunoprecipitation analyses.The effects of FOXA2 on cell proliferation,migration,invasion,and cancer stem cell traits were evaluated using small interfering RNA(siRNA)-mediated silencing.Clinical relevance was examined by analyzing patient datasets and tumor tissue microarrays.Results:FOXA2 expression was significantly elevated in tamoxifen-resistant(TamR)and ERα-negative breast cancer cells compared to that in ERα-positive MCF-7 cells,regardless of tamoxifen treatment or ERαdepletion.Transcriptome and chromatin immunoprecipitation analyses revealed that SETD1A,a histone methyltransferase,directly regulated FOXA2 expression.Functionally,FOXA2 knockdown inhibited the proliferation,migration,invasion,and cancer stem cell properties of TamR cells while restoring tamoxifen sensitivity.High FOXA2 expression was correlated with poor survival and reduced responsiveness to tamoxifen in patients with ER-positive breast cancer.Conclusion:Our findings identified FOXA2 as a key mediator of tamoxifen resistance regulated by SETD1A and suggested that targeting the SETD1A-FOXA2 axis may offer a novel strategy for overcoming endocrine resistance in breast cancer.展开更多
With the large-scale integration of new energy sources,various resources such as energy storage,electric vehicles(EVs),and photovoltaics(PV) have participated in the scheduling of active distribution networks(ADNs),po...With the large-scale integration of new energy sources,various resources such as energy storage,electric vehicles(EVs),and photovoltaics(PV) have participated in the scheduling of active distribution networks(ADNs),posing new challenges to the operation and scheduling of distribution networks.Aiming at the uncertainty of PV and EV,an optimal scheduling model for ADNs based on multi-scenario fuzzy set based charging station resource forecasting is constructed.To address the scheduling uncertainties caused by PV and load forecasting errors,a day-ahead optimal scheduling model based on conditional value at risk(CVaR) for cost assessment is established,with the optimization objectives of minimizing the operation cost of distribution networks and the risk cost caused by forecasting errors.An improved subtractive optimizer algorithm is proposed to solve the model and formulate day-ahead optimization schemes.Secondly,a forecasting model for dispatchable resources in charging stations is constructed based on event-based fuzzy set theory.On this basis,an intraday scheduling model is built to comprehensively utilize the dispatchable resources of charging stations to coordinate with the output of distributed power sources,achieving optimal scheduling with the goal of minimizing operation costs.Finally,an experimental scenario based on the IEEE-33 node system is designed for simulation verification.The comparison of optimal scheduling results shows that the proposed method can fully exploit the potential scheduling resources of charging stations,improving the operation stability of ADNs and the accommodution capacity of new energy.展开更多
The quality of cardiopulmonary resuscitation(CPR) significantly influences survival and neurological outcomes in patients with cardiac arrest(CA).Although mechanical chest compression devices and extracorporeal cardio...The quality of cardiopulmonary resuscitation(CPR) significantly influences survival and neurological outcomes in patients with cardiac arrest(CA).Although mechanical chest compression devices and extracorporeal cardiopulmonary resuscitation(ECPR) have demonstrated some benefits,high-quality manual CPR remained the essential first step,particularly in resource-limited settings.In this study,we examined whether opportunities existed to improve manual CPR performance using preliminary data from our recent survey conducted in a province in western China.We aim to emphasize the importance of improving manual CPR quality before implementing advanced interventions.展开更多
This paper introduces fuzzy N-bipolar soft(FN-BS)sets,a novel mathematical framework designed to enhance multi-criteria decision-making(MCDM)processes under uncertainty.The study addresses a significant limitation in ...This paper introduces fuzzy N-bipolar soft(FN-BS)sets,a novel mathematical framework designed to enhance multi-criteria decision-making(MCDM)processes under uncertainty.The study addresses a significant limitation in existing models by unifying fuzzy logic,the consideration of bipolarity,and the ability to evaluate attributes on a multinary scale.The specific contributions of the FN-BS framework include:(1)a formal definition and settheoretic foundation,(2)the development of two innovative algorithms for solving decision-making(DM)problems,and(3)a comparative analysis demonstrating its superiority over established models.The proposed framework is applied to a real-world case study on selecting vaccination programs across multiple countries,showcasing consistent DM outcomes and exceptional adaptability to complex and uncertain scenarios.These results position FN-BS sets as a versatile and powerful tool for addressing dynamic DM challenges.展开更多
Urban transportation planning involves evaluating multiple conflicting criteria such as accessibility,cost-effectiveness,and environmental impact,often under uncertainty and incomplete information.These complex decisi...Urban transportation planning involves evaluating multiple conflicting criteria such as accessibility,cost-effectiveness,and environmental impact,often under uncertainty and incomplete information.These complex decisions require input from various stakeholders,including planners,policymakers,engineers,and community representatives,whose opinions may differ or contradict.Traditional decision-making approaches struggle to effectively handle such bipolar and multivalued expert evaluations.To address these challenges,we propose a novel decisionmaking framework based on Pythagorean fuzzy N-bipolar soft expert sets.This model allows experts to express both positive and negative opinions on a multinary scale,capturing nuanced judgments with higher accuracy.It introduces algebraic operations and a structured aggregation algorithm to systematically integrate and resolve conflicting expert inputs.Applied to a real-world case study,the framework evaluated five urban transport strategies based on key criteria,producing final scores as follows:improving public transit(−0.70),optimizing traffic signal timing(1.86),enhancing pedestrian infrastructure(3.10),expanding bike lanes(0.59),and implementing congestion pricing(0.77).The results clearly identify enhancing pedestrian infrastructure as the most suitable option,having obtained the highest final score of 3.10.Comparative analysis demonstrates the framework’s superior capability in modeling expert consensus,managing uncertainty,and supporting transparent multi-criteria group decision-making.展开更多
Hypersoft set is an extension of soft set as it further partitions each attribute into its corresponding attribute-valued set.This structure is more flexible and useful as it addresses the limitation of soft set for d...Hypersoft set is an extension of soft set as it further partitions each attribute into its corresponding attribute-valued set.This structure is more flexible and useful as it addresses the limitation of soft set for dealing with the scenarios having disjoint attribute-valued sets corresponding to distinct attributes.The main purpose of this study is to make the existing literature regarding neutrosophic parameterized soft set in line with the need of multi-attribute approximate function.Firstly,we conceptualize the neutrosophic parameterized hypersoft sets under the settings of fuzzy set,intuitionistic fuzzy set and neutrosophic set along with some of their elementary properties and set theoretic operations.Secondly,we propose decision-making-based algorithms with the help of these theories.Moreover,illustrative examples are presented which depict the structural validity for successful application to the problems involving vagueness and uncertainties.Lastly,the generalization of the proposed structure is discussed.展开更多
Due to the numerous variables to take into account as well as the inherent ambiguity and uncertainty,evaluating educational institutions can be difficult.The concept of a possibility Pythagorean fuzzy hypersoft set(pP...Due to the numerous variables to take into account as well as the inherent ambiguity and uncertainty,evaluating educational institutions can be difficult.The concept of a possibility Pythagorean fuzzy hypersoft set(pPyFHSS)is more flexible in this regard than other theoretical fuzzy set-like models,even though some attempts have been made in the literature to address such uncertainties.This study investigates the elementary notions of pPyFHSS including its set-theoretic operations union,intersection,complement,OR-and AND-operations.Some results related to these operations are also modified for pPyFHSS.Additionally,the similarity measures between pPyFHSSs are formulated with the assistance of numerical examples and results.Lastly,an intelligent decision-assisted mechanism is developed with the proposal of a robust algorithm based on similarity measures for solving multi-attribute decision-making(MADM)problems.A case study that helps the decision-makers assess the best educational institution is discussed to validate the suggested system.The algorithmic results are compared with the most pertinent model to evaluate the adaptability of pPyFHSS,as it generalizes the classical possibility fuzzy set-like theoretical models.Similarly,while considering significant evaluating factors,the flexibility of pPyFHSS is observed through structural comparison.展开更多
Let X be a closed simply connected rationally elliptic 4-manifold.The rational homotopy type of homotopy fixed point sets X^(hS^(1))is determined,and based on some relations between X^(hS^(1))and X^(S^(1)),the rationa...Let X be a closed simply connected rationally elliptic 4-manifold.The rational homotopy type of homotopy fixed point sets X^(hS^(1))is determined,and based on some relations between X^(hS^(1))and X^(S^(1)),the rational homotopy type of the fixed point set X^(S^(1))is determined.展开更多
Ensuring a sustainable and eco-friendly environment is essential for promoting a healthy and balanced social life.However,decision-making in such contexts often involves handling vague,imprecise,and uncertain informat...Ensuring a sustainable and eco-friendly environment is essential for promoting a healthy and balanced social life.However,decision-making in such contexts often involves handling vague,imprecise,and uncertain information.To address this challenge,this study presents a novel multi-criteria decision-making(MCDM)approach based on picture fuzzy hypersoft sets(PFHSS),integrating the flexibility of Schweizer-Sklar triangular norm-based aggregation operators.The proposed aggregation mechanisms—weighted average and weighted geometric operators—are formulated using newly defined operational laws under the PFHSS framework and are proven to satisfy essential mathematical properties,such as idempotency,monotonicity,and boundedness.The decision-making model system-atically incorporates both benefit and cost-type criteria,enabling more nuanced evaluations in complex social or environmental decision problems.To enhance interpretability and practical relevance,the study conducts a sensitivity analysis on the Schweizer-Sklar parameter(Δ).The results show that varyingΔaffects the strictness of aggregation,thereby influencing the ranking stability of alternatives.A comparative analysis with existing fuzzy and hypersoft-based MCDM methods confirms the robustness,expressiveness,and adaptability of the proposed approach.Notably,the use of picture fuzzy sets allows for the inclusion of positive,neutral,and negative memberships,offering a richer representation of expert opinions compared to traditional models.A case study focused on green technology adoption for environmental sustainability illustrates the real-world applicability of the proposed method.The analysis confirms that the approach yields consistent and interpretable results,even under varying degrees of decision uncertainty.Overall,this work contributes an efficient and flexible MCDM tool that can support decision-makers in formulating policies aligned with sustainable and socially responsible outcomes.展开更多
Multi-criteria decision-making(MCDM)is essential for handling complex decision problems under uncertainty,especially in fields such as criminal justice,healthcare,and environmental management.Traditional fuzzy MCDM te...Multi-criteria decision-making(MCDM)is essential for handling complex decision problems under uncertainty,especially in fields such as criminal justice,healthcare,and environmental management.Traditional fuzzy MCDM techniques have failed to deal with problems where uncertainty or vagueness is involved.To address this issue,we propose a novel framework that integrates group and overlap functions with Aczel-Alsina(AA)operational laws in the intuitionistic fuzzy set(IFS)environment.Overlap functions capture the degree to which two inputs share common features and are used to find how closely two values or criteria match in uncertain environments,while the Group functions are used to combine different expert opinions into a single collective result.This study introduces four new aggregation operators:Group Overlap function-based intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Weighted Averaging(GOF-IFAAWA)operator,intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Weighted Geometric(GOF-IFAAWG),intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)OrderedWeighted Averaging(GOF-IFAAOWA),and intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Ordered Weighted Geometric(GOF-IFAAOWG),which are rigorously defined and mathematically analyzed and offer improved flexibility in managing overlapping,uncertain,and hesitant information.The properties of these operators are discussed in detail.Further,the effectiveness,validity,activeness,and ability to capture the uncertain information,the developed operators are applied to the AI-based Criminal Justice Policy Selection problem.At last,the comparison analysis between prior and proposed studies has been displayed,and then followed by the conclusion of the result.展开更多
基金Deputyship for Research&Innovation,Ministry of Education in Saudi Arabia for funding this research work through the project number RI-44-0028.
文摘The sustainability of the Internet of Things(IoT)involves various issues,such as poor connectivity,scalability problems,interoperability issues,and energy inefficiency.Although the Sixth Generation of mobile networks(6G)allows for Ultra-Reliable Low-Latency Communication(URLLC),enhanced Mobile Broadband(eMBB),and massive Machine-Type Communications(mMTC)services,it faces deployment challenges such as the short range of sub-THz and THz frequency bands,low capability to penetrate obstacles,and very high path loss.This paper presents a network architecture to enhance the connectivity of wireless IoT mesh networks that employ both 6G and Wi-Fi technologies.In this architecture,local communications are carried through the mesh network,which uses a virtual backbone to relay packets to local nodes,while remote communications are carried through the 6G network.The virtual backbone is created using a heuristic distributed ConnectedDominating Set(CDS)algorithm.In this algorithm,each node uses information collected from its one-and two-hop neighbors to determine its role and find the set of expansion nodes that are used to select the next CDS nodes.The proposed algorithm has O(n)message and O(K)time complexities,where n is the number of nodes in the network,and K is the depth of the cluster.The study proved that the approximation ratio of the algorithmhas an upper bound of 2.06748(3.4306MCDS+4.8185).Performance evaluations compared the size of the CDS against the theoretical limit and recent CDS clustering algorithms.Results indicate that the proposed algorithm has the smallest average slope for the size of the CDS as the number of nodes increases.
基金Supported by the Natural Science Foundation of Shandong Province (No.ZR2023MA031)the Natural Science Foundation of China (No.12201619)。
文摘Submodular optimization is primarily applied in multi-agent systems for tasks such as resource allocation,task assignment,collaborative decision-making,and optimization problems.Maximization of optimizing submodular set functions attracts much attention since the 1970s.A large body of work has been done using approximation algorithms.When the dimension of the independent variable of the set function changes from one tok,it is called ak-submodular set function.Thek-submodular set function,a generalization of the classical submodular set function,arises in diverse fields with varied applications.In many practical scenarios,quantifying the degree of closeness to submodularity becomes essential,leading to concepts such as approximately submodular set functions and the diminishing-return(DR) ratio.This paper investigates ak-dimensional set function under matroid constraints,which may lack full submodularity.Instead,we focus on an approximately non-ksubmodular set function characterized by its DR ratio.Employing a greedy algorithmic approach,we derive an approximation guarantee for this problem.Notably,when the DR ratio is set to one,our results align with existing findings in the literature.Experimental results demonstrate the superiority of our algorithm over the baselines.
文摘Deep learning attentionmechanisms have achieved remarkable progress in computer vision,but still face limitations when handling images with ambiguous boundaries and uncertain feature representations.Conventional attention modules such as SE-Net,CBAM,ECA-Net,and CA adopt a deterministic paradigm,assigning fixed scalar weights to features without modeling ambiguity or confidence.To overcome these limitations,this paper proposes the Fuzzy Attention Network Layer(FANL),which integrates intuitionistic fuzzy set theory with convolutional neural networks to explicitly represent feature uncertainty through membership(μ),non-membership(ν),and hesitation(π)degrees.FANLconsists of four coremodules:(1)feature dimensionality reduction via global pooling,(2)fuzzymodeling using learnable clustering centers,(3)adaptive attention generation through weighted fusion of fuzzy components,and(4)feature refinement through residual connections.A cross-layer guidance mechanism is further introduced to enhance hierarchical feature propagation,allowing high-level semantic features to incorporate fine-grained texture information from shallow layers.Comprehensive experiments on three benchmark datasets—PathMNIST-30000,full PathMNIST,and Blood MNIST—demonstrate the effectiveness and generalizability of FANL.The model achieves 84.41±0.56%accuracy and a 1.69%improvement over the baseline CNN while maintaining lightweight computational complexity.Ablation studies show that removing any component causes a 1.7%–2.0%performance drop,validating the synergistic contribution of each module.Furthermore,FANL provides superior uncertainty calibration(ECE=0.0452)and interpretable selective prediction under uncertainty.Overall,FANL presents an efficient and uncertaintyaware attention framework that improves both accuracy and reliability,offering a promising direction for robust visual recognition under ambiguous or noisy conditions.
文摘Circumlunar abort trajectories constitute a vital contingency return strategy during the translunar phase of crewed lunar missions.This paper proposes a methodology for constructing the solution set of the circumlunar abort trajectory and leverages its advantageous properties to address the optimization design problem of abort trajectories.Initially,a solution set of all feasible abort trajectories,originating from an abort point on the nominal trajectory and complying with fundamental reentry constraints,is formulated through the introduction of two novel design parameters.Subsequently,the geometric characteristics of the solution set,as well as the distributional properties of key iterative constraint responses,including flight time and velocity increment,are analyzed.Finally,the characteristics exhibited in the solution set are employed to directly identify the design parameters of the abort trajectories with minimum flight time and velocity increment,thereby providing solutions to two distinct types of optimization problems.The simulation results for a variety of nominal trajectories,encompassing the reconstruction and redesign of the Apollo13 abort trajectory,validate the proposed method,demonstrating its ability to directly generate optimal abort trajectories.The method proposed in this paper investigates feasible abort trajectories from a global perspective,providing both a framework and convenience for mission planning and iterative optimization in abort trajectory design.
基金supported by Fujian Provincial Natural Science Foundation of China(2024J02022)the NSFC(11571158)+1 种基金supported by the NSFC(12071199)supported by the Young and middle-aged project in Fujian Province(JAT190397)。
文摘A discrete subset S of a topological gyrogroup G with the identity 0 is said to be a suitable set for G if it generates a dense subgyrogroup of G and S∪{0}is closed in G.In this paper,it is proved that each countable Hausdorff topological gyrogroup has a suitable set;moreover,it is shown that each separable metrizable strongly topological gyrogroup has a suitable set.
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF),funded by the Ministry of Education(RS-2023-00248378 and NRF-2020R1A6A1A03043708).
文摘Objectives:Tamoxifen is a key drug that provides endocrine therapy for estrogen receptor(ER)α-positive breast cancer;however,resistance remains a significant clinical challenge.This study aims to investigate the molecular mechanisms of tamoxifen resistance in ERα-positive breast cancer,with particular focus on the role of SET Domain Containing 1A(SETD1A)-driven forkhead box A2(FOXA2)as a key regulator of this resistance.Methods:FOXA2 expression and its regulation by SETD1A were assessed via(quantitative polymerase chain reaction),western blotting,transcriptome profiling,and chromatin immunoprecipitation analyses.The effects of FOXA2 on cell proliferation,migration,invasion,and cancer stem cell traits were evaluated using small interfering RNA(siRNA)-mediated silencing.Clinical relevance was examined by analyzing patient datasets and tumor tissue microarrays.Results:FOXA2 expression was significantly elevated in tamoxifen-resistant(TamR)and ERα-negative breast cancer cells compared to that in ERα-positive MCF-7 cells,regardless of tamoxifen treatment or ERαdepletion.Transcriptome and chromatin immunoprecipitation analyses revealed that SETD1A,a histone methyltransferase,directly regulated FOXA2 expression.Functionally,FOXA2 knockdown inhibited the proliferation,migration,invasion,and cancer stem cell properties of TamR cells while restoring tamoxifen sensitivity.High FOXA2 expression was correlated with poor survival and reduced responsiveness to tamoxifen in patients with ER-positive breast cancer.Conclusion:Our findings identified FOXA2 as a key mediator of tamoxifen resistance regulated by SETD1A and suggested that targeting the SETD1A-FOXA2 axis may offer a novel strategy for overcoming endocrine resistance in breast cancer.
基金Supported by the Technology Project of State Grid Corporation Headquarters(No.5100-202322029A-1-1-ZN)the 2024 Youth Science Foundation Project of China (No.62303006)。
文摘With the large-scale integration of new energy sources,various resources such as energy storage,electric vehicles(EVs),and photovoltaics(PV) have participated in the scheduling of active distribution networks(ADNs),posing new challenges to the operation and scheduling of distribution networks.Aiming at the uncertainty of PV and EV,an optimal scheduling model for ADNs based on multi-scenario fuzzy set based charging station resource forecasting is constructed.To address the scheduling uncertainties caused by PV and load forecasting errors,a day-ahead optimal scheduling model based on conditional value at risk(CVaR) for cost assessment is established,with the optimization objectives of minimizing the operation cost of distribution networks and the risk cost caused by forecasting errors.An improved subtractive optimizer algorithm is proposed to solve the model and formulate day-ahead optimization schemes.Secondly,a forecasting model for dispatchable resources in charging stations is constructed based on event-based fuzzy set theory.On this basis,an intraday scheduling model is built to comprehensively utilize the dispatchable resources of charging stations to coordinate with the output of distributed power sources,achieving optimal scheduling with the goal of minimizing operation costs.Finally,an experimental scenario based on the IEEE-33 node system is designed for simulation verification.The comparison of optimal scheduling results shows that the proposed method can fully exploit the potential scheduling resources of charging stations,improving the operation stability of ADNs and the accommodution capacity of new energy.
文摘The quality of cardiopulmonary resuscitation(CPR) significantly influences survival and neurological outcomes in patients with cardiac arrest(CA).Although mechanical chest compression devices and extracorporeal cardiopulmonary resuscitation(ECPR) have demonstrated some benefits,high-quality manual CPR remained the essential first step,particularly in resource-limited settings.In this study,we examined whether opportunities existed to improve manual CPR performance using preliminary data from our recent survey conducted in a province in western China.We aim to emphasize the importance of improving manual CPR quality before implementing advanced interventions.
文摘This paper introduces fuzzy N-bipolar soft(FN-BS)sets,a novel mathematical framework designed to enhance multi-criteria decision-making(MCDM)processes under uncertainty.The study addresses a significant limitation in existing models by unifying fuzzy logic,the consideration of bipolarity,and the ability to evaluate attributes on a multinary scale.The specific contributions of the FN-BS framework include:(1)a formal definition and settheoretic foundation,(2)the development of two innovative algorithms for solving decision-making(DM)problems,and(3)a comparative analysis demonstrating its superiority over established models.The proposed framework is applied to a real-world case study on selecting vaccination programs across multiple countries,showcasing consistent DM outcomes and exceptional adaptability to complex and uncertain scenarios.These results position FN-BS sets as a versatile and powerful tool for addressing dynamic DM challenges.
文摘Urban transportation planning involves evaluating multiple conflicting criteria such as accessibility,cost-effectiveness,and environmental impact,often under uncertainty and incomplete information.These complex decisions require input from various stakeholders,including planners,policymakers,engineers,and community representatives,whose opinions may differ or contradict.Traditional decision-making approaches struggle to effectively handle such bipolar and multivalued expert evaluations.To address these challenges,we propose a novel decisionmaking framework based on Pythagorean fuzzy N-bipolar soft expert sets.This model allows experts to express both positive and negative opinions on a multinary scale,capturing nuanced judgments with higher accuracy.It introduces algebraic operations and a structured aggregation algorithm to systematically integrate and resolve conflicting expert inputs.Applied to a real-world case study,the framework evaluated five urban transport strategies based on key criteria,producing final scores as follows:improving public transit(−0.70),optimizing traffic signal timing(1.86),enhancing pedestrian infrastructure(3.10),expanding bike lanes(0.59),and implementing congestion pricing(0.77).The results clearly identify enhancing pedestrian infrastructure as the most suitable option,having obtained the highest final score of 3.10.Comparative analysis demonstrates the framework’s superior capability in modeling expert consensus,managing uncertainty,and supporting transparent multi-criteria group decision-making.
文摘Hypersoft set is an extension of soft set as it further partitions each attribute into its corresponding attribute-valued set.This structure is more flexible and useful as it addresses the limitation of soft set for dealing with the scenarios having disjoint attribute-valued sets corresponding to distinct attributes.The main purpose of this study is to make the existing literature regarding neutrosophic parameterized soft set in line with the need of multi-attribute approximate function.Firstly,we conceptualize the neutrosophic parameterized hypersoft sets under the settings of fuzzy set,intuitionistic fuzzy set and neutrosophic set along with some of their elementary properties and set theoretic operations.Secondly,we propose decision-making-based algorithms with the help of these theories.Moreover,illustrative examples are presented which depict the structural validity for successful application to the problems involving vagueness and uncertainties.Lastly,the generalization of the proposed structure is discussed.
基金supported by the Deanship of Graduate Studies and Scientific Research at Qassim University(QU-APC-2024-9/1).
文摘Due to the numerous variables to take into account as well as the inherent ambiguity and uncertainty,evaluating educational institutions can be difficult.The concept of a possibility Pythagorean fuzzy hypersoft set(pPyFHSS)is more flexible in this regard than other theoretical fuzzy set-like models,even though some attempts have been made in the literature to address such uncertainties.This study investigates the elementary notions of pPyFHSS including its set-theoretic operations union,intersection,complement,OR-and AND-operations.Some results related to these operations are also modified for pPyFHSS.Additionally,the similarity measures between pPyFHSSs are formulated with the assistance of numerical examples and results.Lastly,an intelligent decision-assisted mechanism is developed with the proposal of a robust algorithm based on similarity measures for solving multi-attribute decision-making(MADM)problems.A case study that helps the decision-makers assess the best educational institution is discussed to validate the suggested system.The algorithmic results are compared with the most pertinent model to evaluate the adaptability of pPyFHSS,as it generalizes the classical possibility fuzzy set-like theoretical models.Similarly,while considering significant evaluating factors,the flexibility of pPyFHSS is observed through structural comparison.
文摘Let X be a closed simply connected rationally elliptic 4-manifold.The rational homotopy type of homotopy fixed point sets X^(hS^(1))is determined,and based on some relations between X^(hS^(1))and X^(S^(1)),the rational homotopy type of the fixed point set X^(S^(1))is determined.
基金supported by the National Natural Science Foundation of China(No.62172095).
文摘Ensuring a sustainable and eco-friendly environment is essential for promoting a healthy and balanced social life.However,decision-making in such contexts often involves handling vague,imprecise,and uncertain information.To address this challenge,this study presents a novel multi-criteria decision-making(MCDM)approach based on picture fuzzy hypersoft sets(PFHSS),integrating the flexibility of Schweizer-Sklar triangular norm-based aggregation operators.The proposed aggregation mechanisms—weighted average and weighted geometric operators—are formulated using newly defined operational laws under the PFHSS framework and are proven to satisfy essential mathematical properties,such as idempotency,monotonicity,and boundedness.The decision-making model system-atically incorporates both benefit and cost-type criteria,enabling more nuanced evaluations in complex social or environmental decision problems.To enhance interpretability and practical relevance,the study conducts a sensitivity analysis on the Schweizer-Sklar parameter(Δ).The results show that varyingΔaffects the strictness of aggregation,thereby influencing the ranking stability of alternatives.A comparative analysis with existing fuzzy and hypersoft-based MCDM methods confirms the robustness,expressiveness,and adaptability of the proposed approach.Notably,the use of picture fuzzy sets allows for the inclusion of positive,neutral,and negative memberships,offering a richer representation of expert opinions compared to traditional models.A case study focused on green technology adoption for environmental sustainability illustrates the real-world applicability of the proposed method.The analysis confirms that the approach yields consistent and interpretable results,even under varying degrees of decision uncertainty.Overall,this work contributes an efficient and flexible MCDM tool that can support decision-makers in formulating policies aligned with sustainable and socially responsible outcomes.
基金supported by“1 Decembrie 1918”University of Alba Iulia,510009 Alba Iuliasupported in part by the HEC-NRPU project,under the grant No.14566.
文摘Multi-criteria decision-making(MCDM)is essential for handling complex decision problems under uncertainty,especially in fields such as criminal justice,healthcare,and environmental management.Traditional fuzzy MCDM techniques have failed to deal with problems where uncertainty or vagueness is involved.To address this issue,we propose a novel framework that integrates group and overlap functions with Aczel-Alsina(AA)operational laws in the intuitionistic fuzzy set(IFS)environment.Overlap functions capture the degree to which two inputs share common features and are used to find how closely two values or criteria match in uncertain environments,while the Group functions are used to combine different expert opinions into a single collective result.This study introduces four new aggregation operators:Group Overlap function-based intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Weighted Averaging(GOF-IFAAWA)operator,intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Weighted Geometric(GOF-IFAAWG),intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)OrderedWeighted Averaging(GOF-IFAAOWA),and intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Ordered Weighted Geometric(GOF-IFAAOWG),which are rigorously defined and mathematically analyzed and offer improved flexibility in managing overlapping,uncertain,and hesitant information.The properties of these operators are discussed in detail.Further,the effectiveness,validity,activeness,and ability to capture the uncertain information,the developed operators are applied to the AI-based Criminal Justice Policy Selection problem.At last,the comparison analysis between prior and proposed studies has been displayed,and then followed by the conclusion of the result.
