Building the new countryside construction database plays an important role in improving the construction efficiency,and enhancing the level of major project management.On the basis of detailed analysis of features of ...Building the new countryside construction database plays an important role in improving the construction efficiency,and enhancing the level of major project management.On the basis of detailed analysis of features of the new countryside construction data,we give an overview of the database design based on ArcSDE and SQL Server,and elaborate the association between data classification organization,database conceptual design,logical design,spatial data,and thematic attribute data.Finally,taking the provincial new countryside demonstration zone in Yanjiang District of Sichuan Province for example,we build the new countryside construction database.展开更多
Background:The purpose of this study was to analyze and classify adverse drug events(ADEs)related to ceftazidime/avibactam reported in the Food and Drug Administration Adverse Event Reporting System(FAERS)database and...Background:The purpose of this study was to analyze and classify adverse drug events(ADEs)related to ceftazidime/avibactam reported in the Food and Drug Administration Adverse Event Reporting System(FAERS)database and to evaluate their potential safety signals since the drug’s market introduction.Methods:This analysis systematically extracted and filtered FAERS data for ceftazidime/avibactam from its market launch in 2015 to the last quarter of 2024,utilizing the Medical Dictionary for Regulatory Activities(MedDRA)terminology for ADE recoding.The analysis employed the reporting odds ratio(ROR)method to assess the strength of ADE signals and to identify significant diseases associated with infections,the hepatobiliary system,the urinary system,and the nervous system.Results:A review of 540 adverse reaction reports revealed significant signals of adverse effects related to infections,hepatobiliary disorders,urinary system issues,and neurological impairments,including pathogen resistance,liver and kidney function impairment,encephalopathy,thrombocytopenia,and toxic epidermal necrolysis.However,these issues require further clinical attention.Conclusion:Ceftazidime/avibactam is associated with a range of adverse reactions,necessitating enhanced clinical monitoring,particularly in patients with underlying liver or kidney dysfunction.Continuous risk assessment and vigilant monitoring are critical for its clinical use.However,this study is limited by inherent reporting biases and confounders associated with the spontaneous reporting database(FAERS).Future research should validate these signals through prospective cohort and mechanistic studies and explore personalized risk management strategies for high-risk populations.展开更多
Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)d...Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.展开更多
WebGIS是GIS的一个重要的发展方向.本文主要研究基于ArcGIS Server Java ADF和JSF框架的Web-GIS产品开发的关键性技术。文章首先介绍了JSF和ArcGIS Server Java ADF的基本知识,然后对ArcGIS Server Ja-va ADF基本开发技术进行了深入分析...WebGIS是GIS的一个重要的发展方向.本文主要研究基于ArcGIS Server Java ADF和JSF框架的Web-GIS产品开发的关键性技术。文章首先介绍了JSF和ArcGIS Server Java ADF的基本知识,然后对ArcGIS Server Ja-va ADF基本开发技术进行了深入分析,最后以村镇民俗旅游资源空间化分析系统为例,总结了开发此类程序的基本框架。展开更多
提高数据挖掘的效率是目前信息技术研究的热点问题之一。介绍了数据挖掘的概念、过程模型以及体系结构,讨论了基于Microsoft SQL Server 2005的数据挖掘方案和采用SQL Server分析服务实现数据挖掘的相关技术。采用SQLServer分析服务的...提高数据挖掘的效率是目前信息技术研究的热点问题之一。介绍了数据挖掘的概念、过程模型以及体系结构,讨论了基于Microsoft SQL Server 2005的数据挖掘方案和采用SQL Server分析服务实现数据挖掘的相关技术。采用SQLServer分析服务的数据挖掘,实现了数据挖掘、数据仓库与应用程序的紧密耦合,从而大大提高了数据挖掘的效率。展开更多
BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram ...BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.展开更多
The characteristic databases in China face issues such as narrow resource coverage,low levels of standardization and normalization,and limited data sharing.To address these challenges,this paper proposes the concept o...The characteristic databases in China face issues such as narrow resource coverage,low levels of standardization and normalization,and limited data sharing.To address these challenges,this paper proposes the concept of characteristic databases alliance,using marine characteristic databases as a case for feasibility analysis and discussion.The paper outlines the development path for such alliances and offers recommendations for future growth,aiming to establish a collaborative platform for the development of characteristic databases.展开更多
The journal of Meteorological and Environmental Research [ISSN: 2152-3940] has been included and stored by the following famous databases: CA, CABI, CSA, EBSCO, UPD, AGRIS, EA, Chinese Science and Technology Periodica...The journal of Meteorological and Environmental Research [ISSN: 2152-3940] has been included and stored by the following famous databases: CA, CABI, CSA, EBSCO, UPD, AGRIS, EA, Chinese Science and Technology Periodical Database, and CNKI, as well as Library of Congress, United States.展开更多
The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,...The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.展开更多
The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,...The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.展开更多
AI-driven materials databases are transforming research by integrating experimental and computational data to enhance discovery and optimization.Platforms such as Digital Catalysis Platform(DigCat)and Dynamic Database...AI-driven materials databases are transforming research by integrating experimental and computational data to enhance discovery and optimization.Platforms such as Digital Catalysis Platform(DigCat)and Dynamic Database of Solid-State Electrolyte(DDSE)demonstrate how machine learning and predictive modeling can improve catalyst and solid-state electrolyte development.These databases facilitate data standardization,high-throughput screening,and cross-disciplinary collaboration,addressing key challenges in materials informatics.As AI techniques advance,materials databases are expected to play an increasingly vital role in accelerating research and innovation.展开更多
Objective:This study aimed to investigate the changes in gene expression profiles of multiple myeloma(MM)cells after bortezomib treatment by analyzing the GEO database,thereby providing a theoretical foundation for su...Objective:This study aimed to investigate the changes in gene expression profiles of multiple myeloma(MM)cells after bortezomib treatment by analyzing the GEO database,thereby providing a theoretical foundation for subsequent research on HSP70.Methods:The GSE41929 dataset was selected from the GEO database.Screening and analysis were performed to identify differentially expressed genes between bortezomib-treated and non-treated MM cells.Results:After bortezomib treatment,126 genes in MM cells showed the most significant changes in expression(P<0.05,absolute value of logFC≥1.5).Based on the fold change and the most significant gene module,HSPA1B exhibited the most notable upregulation after HMOX1,followed by HSPA6 and DNAJB1.HSPA1B and HSPA6 are members of the HSP70 protein family,while DNAJB1 primarily interacts with HSP70 to stimulate its ATPase activity and negatively regulates the transcriptional activity of HSF1 induced by heat shock.Conclusion:HSP70 was the most significantly upregulated molecule in MM cells following bortezomib stimulation.展开更多
基金Supported by Fundamental Research Project of Sichuan Provincial Department of Finance in 2012
文摘Building the new countryside construction database plays an important role in improving the construction efficiency,and enhancing the level of major project management.On the basis of detailed analysis of features of the new countryside construction data,we give an overview of the database design based on ArcSDE and SQL Server,and elaborate the association between data classification organization,database conceptual design,logical design,spatial data,and thematic attribute data.Finally,taking the provincial new countryside demonstration zone in Yanjiang District of Sichuan Province for example,we build the new countryside construction database.
基金Intramural Project of The First Affiliated Hospital of Guangxi University of Chinese Medicine(2018QN008).
文摘Background:The purpose of this study was to analyze and classify adverse drug events(ADEs)related to ceftazidime/avibactam reported in the Food and Drug Administration Adverse Event Reporting System(FAERS)database and to evaluate their potential safety signals since the drug’s market introduction.Methods:This analysis systematically extracted and filtered FAERS data for ceftazidime/avibactam from its market launch in 2015 to the last quarter of 2024,utilizing the Medical Dictionary for Regulatory Activities(MedDRA)terminology for ADE recoding.The analysis employed the reporting odds ratio(ROR)method to assess the strength of ADE signals and to identify significant diseases associated with infections,the hepatobiliary system,the urinary system,and the nervous system.Results:A review of 540 adverse reaction reports revealed significant signals of adverse effects related to infections,hepatobiliary disorders,urinary system issues,and neurological impairments,including pathogen resistance,liver and kidney function impairment,encephalopathy,thrombocytopenia,and toxic epidermal necrolysis.However,these issues require further clinical attention.Conclusion:Ceftazidime/avibactam is associated with a range of adverse reactions,necessitating enhanced clinical monitoring,particularly in patients with underlying liver or kidney dysfunction.Continuous risk assessment and vigilant monitoring are critical for its clinical use.However,this study is limited by inherent reporting biases and confounders associated with the spontaneous reporting database(FAERS).Future research should validate these signals through prospective cohort and mechanistic studies and explore personalized risk management strategies for high-risk populations.
基金supported by the National Key Research&Development Program of China(No.2024YFC3505800)the National Natural Science Foundation of China(Nos.82474334,82474335 and 72174132)+3 种基金National Science Fund for Distinguished Young Scholars(No.82225049)the Key Research&Development Projects of Sichuan Provincial Department of Science and Technology(Nos.2024YFFK0174 and 2024YFFK0152)1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYYC24010 and ZYGD23004)the Special Fund for Traditional Chinese Medicine of Sichuan Provincial Administration of Traditional Chinese Medicine(No.2024zd023).
文摘Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.
文摘WebGIS是GIS的一个重要的发展方向.本文主要研究基于ArcGIS Server Java ADF和JSF框架的Web-GIS产品开发的关键性技术。文章首先介绍了JSF和ArcGIS Server Java ADF的基本知识,然后对ArcGIS Server Ja-va ADF基本开发技术进行了深入分析,最后以村镇民俗旅游资源空间化分析系统为例,总结了开发此类程序的基本框架。
文摘提高数据挖掘的效率是目前信息技术研究的热点问题之一。介绍了数据挖掘的概念、过程模型以及体系结构,讨论了基于Microsoft SQL Server 2005的数据挖掘方案和采用SQL Server分析服务实现数据挖掘的相关技术。采用SQLServer分析服务的数据挖掘,实现了数据挖掘、数据仓库与应用程序的紧密耦合,从而大大提高了数据挖掘的效率。
基金Supported by the Appropriate Technology Promotion Program in Chongqing,No.2023jstg005.
文摘BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.
文摘The characteristic databases in China face issues such as narrow resource coverage,low levels of standardization and normalization,and limited data sharing.To address these challenges,this paper proposes the concept of characteristic databases alliance,using marine characteristic databases as a case for feasibility analysis and discussion.The paper outlines the development path for such alliances and offers recommendations for future growth,aiming to establish a collaborative platform for the development of characteristic databases.
文摘The journal of Meteorological and Environmental Research [ISSN: 2152-3940] has been included and stored by the following famous databases: CA, CABI, CSA, EBSCO, UPD, AGRIS, EA, Chinese Science and Technology Periodical Database, and CNKI, as well as Library of Congress, United States.
文摘The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.
文摘The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.
文摘AI-driven materials databases are transforming research by integrating experimental and computational data to enhance discovery and optimization.Platforms such as Digital Catalysis Platform(DigCat)and Dynamic Database of Solid-State Electrolyte(DDSE)demonstrate how machine learning and predictive modeling can improve catalyst and solid-state electrolyte development.These databases facilitate data standardization,high-throughput screening,and cross-disciplinary collaboration,addressing key challenges in materials informatics.As AI techniques advance,materials databases are expected to play an increasingly vital role in accelerating research and innovation.
基金The Innovation Capability Support Program for Medical Research Projects of Xi’an Science and Technology Bureau(23YXYJ0123)The Hospital Level Fund of the First Affiliated Hospital of Xi’an Medical University(XYYFY-2023-08)。
文摘Objective:This study aimed to investigate the changes in gene expression profiles of multiple myeloma(MM)cells after bortezomib treatment by analyzing the GEO database,thereby providing a theoretical foundation for subsequent research on HSP70.Methods:The GSE41929 dataset was selected from the GEO database.Screening and analysis were performed to identify differentially expressed genes between bortezomib-treated and non-treated MM cells.Results:After bortezomib treatment,126 genes in MM cells showed the most significant changes in expression(P<0.05,absolute value of logFC≥1.5).Based on the fold change and the most significant gene module,HSPA1B exhibited the most notable upregulation after HMOX1,followed by HSPA6 and DNAJB1.HSPA1B and HSPA6 are members of the HSP70 protein family,while DNAJB1 primarily interacts with HSP70 to stimulate its ATPase activity and negatively regulates the transcriptional activity of HSF1 induced by heat shock.Conclusion:HSP70 was the most significantly upregulated molecule in MM cells following bortezomib stimulation.
