A new set of binary sequences-Periodic Complementary Binary Sequence Pair (PCSP) is proposed. A new class of block design-Difference Family Pair (DFP) is also proposed.The relationship between PCSP and DFP, the proper...A new set of binary sequences-Periodic Complementary Binary Sequence Pair (PCSP) is proposed. A new class of block design-Difference Family Pair (DFP) is also proposed.The relationship between PCSP and DFP, the properties and existing conditions of PCSP and the recursive constructions for PCSP are given.展开更多
In this paper,a new class of almost binary sequence pair with a single zero element is presented.The almost binary sequence pairs with three-level correlation are constructed based on cyclotomic numbers of order 2,4,a...In this paper,a new class of almost binary sequence pair with a single zero element is presented.The almost binary sequence pairs with three-level correlation are constructed based on cyclotomic numbers of order 2,4,and 6.Most of them have good correlation and balance property,whose maximum nontrivial correlation magnitudes are 2 and the difference between the numbers of occurrence of +1's and-1's are 0 or 1.In addition,the corresponding binary sequence pairs are investigated as well and we can also get some kinds of binary sequence pairs with optimum balance and good correlation.展开更多
The concept of the binary sequence pair is generalized from a single binary sequence. Binary sequence pairs are applied in many fields of radar, sonar or communication systems, in which signals with optimal periodic c...The concept of the binary sequence pair is generalized from a single binary sequence. Binary sequence pairs are applied in many fields of radar, sonar or communication systems, in which signals with optimal periodic correlation are required. Several types of almost perfect binary sequence pairs of length T = 2q are constructed, where q is an odd number. These almost perfect binary sequence pairs are based on binary ideal sequence or binary ideal two-level correlation sequence pairs by using Chinese remainder theorem. For these almost perfect binary sequence pairs with good balanced property, their corresponding divisible difference set pairs(DDSPs) are also derived.展开更多
BACKGROUND Understanding the status and function of tumor-infiltrating immune cells is essential for improving immunotherapeutic effects and predicting the clinical response in human patients with carcinoma.However,li...BACKGROUND Understanding the status and function of tumor-infiltrating immune cells is essential for improving immunotherapeutic effects and predicting the clinical response in human patients with carcinoma.However,little is known about tumor-infiltrating immune cells,and the corresponding research results in hepatocellular carcinoma(HCC)are limited.AIM To investigate potential biomarker genes that are important for the development of HCC and to understand how immune cell subsets react throughout this process.METHODS Using single-cell RNA sequencing and T-cell receptor sequencing,the heterogeneity and potential functions of immune cell subpopulations from HCC tissue and normal tissue adjacent to carcinoma,as well as their possible interactions,were analyzed.RESULTS Eight T-cell clusters from patients were analyzed and identified using bioinformatics,including six typical major Tcell clusters and two newly identified T-cell clusters,among which Fc epsilon receptor 1G+T cells were characterized by the upregulation of Fc epsilon receptor 1G,tyrosine kinase binding protein,and T cell receptor delta constant,whereas metallothionein 1E+T cells proliferated significantly in tumors.Differentially expressed genes,such as regulator of cell cycle,cysteine and serine rich nuclear protein 1,SMAD7 and metallothionein 1E,were identified as significantly upregulated in tumors and have potential as biomarkers.In association with T-cell receptor analysis,we inferred the clonal expansion characteristics of each T-cell cluster in HCC patients.CONCLUSION We identified lymphocyte subpopulations and potential biomarker genes critical for HCC development and revealed the clonal amplification of infiltrating T cells.These data provide valuable resources for understanding the response of immune cell subsets in HCC.展开更多
In this paper, the perfect dyadic binary sequence pair with one-value dyadic correlation functions is presented. That is, the perfect dyadic binary sequence pair is a perfect discrete signal, for its dyadic relative f...In this paper, the perfect dyadic binary sequence pair with one-value dyadic correlation functions is presented. That is, the perfect dyadic binary sequence pair is a perfect discrete signal, for its dyadic relative function is δ-function. The transformation features and some existing admissibility conditions of perfect dyadic binary sequence pair are discussed, and the properties for this kind of code in Walsh transformation spectrum and weight spectrum are also analyzed. From above, It is found that the perfect dyadic binary sequence pair can easily differentiate from its dyadic shifting. So these good signals can used in engineering as synchronization code, multi-user code and so on.展开更多
基金Supported by National Natural Science Foundation of China (69972042),Natural Science Fund of Hebei Provice(599245)and Science Foundation of Yanshan University
文摘A new set of binary sequences-Periodic Complementary Binary Sequence Pair (PCSP) is proposed. A new class of block design-Difference Family Pair (DFP) is also proposed.The relationship between PCSP and DFP, the properties and existing conditions of PCSP and the recursive constructions for PCSP are given.
基金Supported by the National Natural Science Foundation of China (No. 60872061,60971126,and 61172094)
文摘In this paper,a new class of almost binary sequence pair with a single zero element is presented.The almost binary sequence pairs with three-level correlation are constructed based on cyclotomic numbers of order 2,4,and 6.Most of them have good correlation and balance property,whose maximum nontrivial correlation magnitudes are 2 and the difference between the numbers of occurrence of +1's and-1's are 0 or 1.In addition,the corresponding binary sequence pairs are investigated as well and we can also get some kinds of binary sequence pairs with optimum balance and good correlation.
基金supported by the National Natural Science Foundation of China(6160140161501395+6 种基金6160139961671402)Natural Science Foundation of Hebei Province(F2015203150F2016203293F2016203312)Natural Science Research Programs of Hebei Educational Committee(QN2016120)the Independent Research Programs for Young Teachers of Yanshan University(15LGB013)
文摘The concept of the binary sequence pair is generalized from a single binary sequence. Binary sequence pairs are applied in many fields of radar, sonar or communication systems, in which signals with optimal periodic correlation are required. Several types of almost perfect binary sequence pairs of length T = 2q are constructed, where q is an odd number. These almost perfect binary sequence pairs are based on binary ideal sequence or binary ideal two-level correlation sequence pairs by using Chinese remainder theorem. For these almost perfect binary sequence pairs with good balanced property, their corresponding divisible difference set pairs(DDSPs) are also derived.
基金Supported by the Scientific Research Topic of Jiangsu Provincial Health Care Commission,No.M2021017the High-level Talent Research Project of the Second Hospital of Nanjing,No.0313504the Nanjing Second Hospital Academic Leader Program,No.0313506.
文摘BACKGROUND Understanding the status and function of tumor-infiltrating immune cells is essential for improving immunotherapeutic effects and predicting the clinical response in human patients with carcinoma.However,little is known about tumor-infiltrating immune cells,and the corresponding research results in hepatocellular carcinoma(HCC)are limited.AIM To investigate potential biomarker genes that are important for the development of HCC and to understand how immune cell subsets react throughout this process.METHODS Using single-cell RNA sequencing and T-cell receptor sequencing,the heterogeneity and potential functions of immune cell subpopulations from HCC tissue and normal tissue adjacent to carcinoma,as well as their possible interactions,were analyzed.RESULTS Eight T-cell clusters from patients were analyzed and identified using bioinformatics,including six typical major Tcell clusters and two newly identified T-cell clusters,among which Fc epsilon receptor 1G+T cells were characterized by the upregulation of Fc epsilon receptor 1G,tyrosine kinase binding protein,and T cell receptor delta constant,whereas metallothionein 1E+T cells proliferated significantly in tumors.Differentially expressed genes,such as regulator of cell cycle,cysteine and serine rich nuclear protein 1,SMAD7 and metallothionein 1E,were identified as significantly upregulated in tumors and have potential as biomarkers.In association with T-cell receptor analysis,we inferred the clonal expansion characteristics of each T-cell cluster in HCC patients.CONCLUSION We identified lymphocyte subpopulations and potential biomarker genes critical for HCC development and revealed the clonal amplification of infiltrating T cells.These data provide valuable resources for understanding the response of immune cell subsets in HCC.
基金Supported by the National Natural Science Foundation of China (No.60372097)Beijing Municipal Natural Science Foundation (No.4052021)University IT Re-search Center Project (INHA UWB-ITRC), Korea.
文摘In this paper, the perfect dyadic binary sequence pair with one-value dyadic correlation functions is presented. That is, the perfect dyadic binary sequence pair is a perfect discrete signal, for its dyadic relative function is δ-function. The transformation features and some existing admissibility conditions of perfect dyadic binary sequence pair are discussed, and the properties for this kind of code in Walsh transformation spectrum and weight spectrum are also analyzed. From above, It is found that the perfect dyadic binary sequence pair can easily differentiate from its dyadic shifting. So these good signals can used in engineering as synchronization code, multi-user code and so on.
