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Constructions of Control Sequence Set for Hierarchical Access in Data Link Network
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作者 Niu Xianhua Ma Jiabei +3 位作者 Zhou Enzhi Wang Yaoxuan Zeng Bosen Li Zhiping 《China Communications》 2026年第1期67-80,共14页
As an important resource in data link,time slots should be strategically allocated to enhance transmission efficiency and resist eavesdropping,especially considering the tremendous increase in the number of nodes and ... As an important resource in data link,time slots should be strategically allocated to enhance transmission efficiency and resist eavesdropping,especially considering the tremendous increase in the number of nodes and diverse communication needs.It is crucial to design control sequences with robust randomness and conflict-freeness to properly address differentiated access control in data link.In this paper,we propose a hierarchical access control scheme based on control sequences to achieve high utilization of time slots and differentiated access control.A theoretical bound of the hierarchical control sequence set is derived to characterize the constraints on the parameters of the sequence set.Moreover,two classes of optimal hierarchical control sequence sets satisfying the theoretical bound are constructed,both of which enable the scheme to achieve maximum utilization of time slots.Compared with the fixed time slot allocation scheme,our scheme reduces the symbol error rate by up to 9%,which indicates a significant improvement in anti-interference and eavesdropping capabilities. 展开更多
关键词 control sequence data link hierarchical access control theoretical bound
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A New Construction of Stefan’s Homological Spectral Sequence
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作者 LIU Li-yu 《Chinese Quarterly Journal of Mathematics》 2026年第1期60-67,共8页
In this paper,we offer a new construction of Stefan’s homological spectral sequence for Hopf Galois extensions,by using the double complex argument.Under the faithfully flat condition,a method for computation of Hoch... In this paper,we offer a new construction of Stefan’s homological spectral sequence for Hopf Galois extensions,by using the double complex argument.Under the faithfully flat condition,a method for computation of Hochschild homology is given. 展开更多
关键词 Hopf algebra Hopf Galois extension Spectral sequence Hochschild homology
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Sedimentary Characteristics and Evolution of the High-resolution Sequence Stratigraphic Framework of the Taiyuan Formation in the Hangjinqi Area,Northern Ordos Basin
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作者 ZHAO Mingsheng TIAN Jingchun +1 位作者 SU Bingrui ZHANG Xiang 《Acta Geologica Sinica(English Edition)》 2026年第1期54-68,共15页
The Ordos Basin is a large superimposed hydrocarbon-bearing basin in China,and further research on the sedimentary characteristics and sedimentary evolution of the sequence framework of target layers is of great theor... The Ordos Basin is a large superimposed hydrocarbon-bearing basin in China,and further research on the sedimentary characteristics and sedimentary evolution of the sequence framework of target layers is of great theoretical and practical significance for guiding oil and gas exploration.The sedimentary facies and sedimentary evolution of the high-resolution sequence framework of the Carboniferous Taiyuan Formation in the Hangjinqi area have been systematically analyzed for the first time by drilling,logging and seismic data.The results show that four types of sequence interfaces can be identified in the Taiyuan Formation:regional unconformity surfaces,scour surfaces,lithologic-lithofacies transformation surfaces and flooding surfaces.According to the sedimentary response caused by the upward and downward movements of the base level at different levels,the Taiyuan Formation can be divided into 2 long-term cycles(LSC_(1)-LSC_(2)),4 mid-term cycles(MSC_(1)-MSC4)and 7 short-term cycles(SSC_(1)-SSC7).The long-and mid-term cycles correspond to members T_(1)and T_(2)and layers T_(1)-1,T_(1-2),T_(2-1),and T_(2)-2,respectively.Long-term cycles are dominated by C_(1);mid-term cycles are dominated by C_(1)and C_(2),followed by A2;and short-term cycles are dominated by C_(1),C_(2),A1 and A2.Under the high-resolution sequence stratigraphic framework,the Hangjinqi area underwent a transformation of fan delta and tidal flat depositional systems during the Taiyuan Formation sedimentary period.In the MSC_(1)-MSC_(2)stage,owing to a large-scale paleocontinent,the fan delta sedimentary body,which was limited in scale and scope,developed only in the southeastern corner and gradually transitioned basinward to tidal flat facies.In the MSC3-MSC4 stage,as the paleocontinent continuously decreased and the sedimentary range expanded,fan-delta plain sedimentation began in the study area.Several braided distributary channels with poor connectivity developed on the fan-delta plain,and between them were floodplains and peat swamps. 展开更多
关键词 high-resolution sequence framework sedimentary characteristics sedimentary evolution Taiyuan Formation Hangjinqi area northern Ordos Basin
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Genetic diversity and population structure of the Fujian oyster Crassostrea angulata revealed by mitochondrial COI gene and nuclear gene ITS2 sequences
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作者 Shiqi YU Ziqiang HAN Huayong QUE 《Journal of Oceanology and Limnology》 2026年第1期419-432,共14页
The Fujian oyster(Crassostrea angulata) is an economically significant shellfish species distributed mainly along the Fujian coast, Southeast China. However, its genetic diversity and structure remain unclear. The mai... The Fujian oyster(Crassostrea angulata) is an economically significant shellfish species distributed mainly along the Fujian coast, Southeast China. However, its genetic diversity and structure remain unclear. The main distribution area of the C. angulata is located in Fujian, South China. In total, 420 C. angulata were collected from 14 natural habitats(populations) along the Fujian coast, and their genetic diversity and structure were analyzed in the mitochondrial COI and nuclear gene ITS2 sequences. Results reveal that all the 14 populations of C. angulata exhibited high levels of genetic diversity, with a total of 57(haplotype diversity: 0.811±0.016) and 124(haplotype diversity: 0.912±0.007) haplotypes revealed by COI and ITS2, respectively. Notably, significant intermediate level of genetic differentiations between the Ningde Zhujiang(ZJ) population(FS T by COI: 0.035–0.142, P<0.05;FS T by ITS2: 0.078–0.123, P<0.05) with other populations were observed for the first time, which is also supported by the results of molecular variance analysis(FC T by COI: 0.105, P<0.05;FC T by ITS2: 0.086, P<0.05) and the clustering of the ZJ population into distinct branches in the interpopulation genetic differentiation tree. Furthermore, the evolutionary tree and haplotype network analyses do not support the formation of a clear geographical genealogical structure among these 14 populations. In addition, the population dynamics analysis suggests that the C. angulata may have undergone expansion during the third ice age of the Pleistocene. These results provide a reference for the preservation and further genetic improvement of C. angulata. 展开更多
关键词 Crassostrea angulata genetic diversity population structure mitochondrial COⅠgene nuclear gene ITS2 sequence
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Robust Hyper-Polarization Protocol of Nuclear Spins via Magic Sequence
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作者 Haiyang Li Yongju Li +1 位作者 Hao Liao Ping Wang 《Chinese Physics Letters》 2026年第1期105-128,共24页
Hyperpolarization of nuclear spins is crucial for advancing nuclear magnetic resonance and quantum information technologies,as nuclear spins typically exhibit extremely low polarization at room temperature due to thei... Hyperpolarization of nuclear spins is crucial for advancing nuclear magnetic resonance and quantum information technologies,as nuclear spins typically exhibit extremely low polarization at room temperature due to their small gyromagnetic ratios.A promising approach to achieving high nuclear spin polarization is transferring the polarization of electrons to nuclear spins.The nitrogen-vacancy(NV)center in diamond has emerged as a highly effective medium for this purpose,and various hyperpolarization protocols have been developed.Among these,the pulsed polarization(PulsePol)method has been extensively studied due to its robustness against static energy shifts of the electron spin.In this work,we present a novel polarization protocol and uncover a family of magic sequences for hyperpolarizing nuclear spins,with PulsePol emerging as a special case of our general approach.Notably,we demonstrate that some of these magic sequences exhibit significantly greater robustness compared to the PulsePol protocol in the presence of finite half𝜋pulse duration of the protocol,Rabi and detuning errors.This enhanced robustness positions our protocol as a more suitable candidate for hyper-polarizing nuclear spins species with large gyromagnetic ratios and also ensures better compatibility with high-efficiency readout techniques at high magnetic fields.Additionally,the generality of our protocol allows for its direct application to other solid-state quantum systems beyond the NV center. 展开更多
关键词 transferring polarization electrons hyperpolarization protocols quantum information technologiesas nuclear spins pulse polarization nuclear spin polarization magic sequences nuclear magnetic resonance
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Stochastic discrete event simulation for government assisted owner driven participatory housing recovery modeling:Application to 2015 Gorkha earthquake sequence,Nepal
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作者 Dipendra Gautam Sajan KC Olafur Petur Palsson 《Resilient Cities and Structures》 2026年第1期45-59,共15页
We develop and implement a Stochastic Discrete Event Simulation(SDES)algorithm to model the housing re-covery trajectory after an extreme event.The algorithm models discrete events and their underlying uncertainties i... We develop and implement a Stochastic Discrete Event Simulation(SDES)algorithm to model the housing re-covery trajectory after an extreme event.The algorithm models discrete events and their underlying uncertainties in each construction phase.Specifically,the algorithm is developed for the Government Assisted Owner Driven(GAOD)reconstruction system to simulate long-term recovery trajectory.SDES,as a flexible modeling approach,can simulate any housing recovery scenario that follows phased reconstruction.The 2015 M 7.8 Gorkha earthquake sequence in Nepal is considered the extreme event,with 796,245 buildings requiring reconstruction.We present some recovery trajectories from severely hit,crisis hit,and earthquake hit parishes,comparing them with the actual reconstruction progress.We also assess quality and improvement of reconstructed buildings using seismic fragility functions,compared to pre-earthquake constructions.Housing recovery uncertainties are dissected in relation to reconstruction pace.We conclude that the vast majority of the reconstructed buildings followed the Build Back Better(BBB)approach and missed the opportunity to pursue the Build Back Resilient(BBR)approach due to multifaceted challenges ranging from unclear policies to economic constraints.We critically assess the GAOD vs Owner Driven(OD)recovery framework and conclude that insurance-supported and technically assisted OD approach could be the most suitable model for post extreme event housing recovery. 展开更多
关键词 Stochastic modeling Discrete event simulation Participatory reconstruction Housing recovery Community resilience Earthquake damage Reinforced concrete Stone masonry Brick masonry Seismic vulnerability Gorkha earthquake sequence
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基于油气润滑的TPS高速球轴承腔温升研究
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作者 尚春民 关欣雨 +1 位作者 邱李杰 张心明 《机械设计与制造》 北大核心 2025年第6期268-273,279,共7页
针对涡轮动力模拟器(TPS)系统中主轴轴承在油气润滑的条件下转速升高温升加剧的问题,以主轴角接触球轴承腔为研究对象,在考虑自旋因素下进行摩擦力矩热功率的数值计算。采用Eulerian多相流模型进行轴承腔温度场仿真分析,并与试验测得的... 针对涡轮动力模拟器(TPS)系统中主轴轴承在油气润滑的条件下转速升高温升加剧的问题,以主轴角接触球轴承腔为研究对象,在考虑自旋因素下进行摩擦力矩热功率的数值计算。采用Eulerian多相流模型进行轴承腔温度场仿真分析,并与试验测得的数据进行对比研究。结果表明:随供气压力的增大轴承腔温度降低,但持续增大供气压力会导致轴承腔温度不稳定,因此TPS系统最佳供气压力在(0.3~0.4)MPa之间;在入口倾角的作用下,内滚道壁面温度变化稳定,内外滚道最高温度差达到10℃以上;随转速升高,轴承腔内最高温度位置越接近润滑点,油气两相流降温程度越明显。 展开更多
关键词 油气润滑 tps 角接触球轴承 温度场 仿真 供气压力
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MDT模式结合TPS教学法在妇科恶性肿瘤临床教学中的应用探讨
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作者 熊晶 谭朝霞 张文 《长沙民政职业技术学院学报》 2025年第3期107-111,共5页
本研究运用MDT模式结合TPS教学法探讨在临床医学八年制学生妇科恶性肿瘤教学中的应用效果和价值。选取在中南大学湘雅二医院妇产科学习的八年制学生共36人,随机分配至观察组与对照组,每组各有18名学生。以卵巢恶性肿瘤为教学内容,观察... 本研究运用MDT模式结合TPS教学法探讨在临床医学八年制学生妇科恶性肿瘤教学中的应用效果和价值。选取在中南大学湘雅二医院妇产科学习的八年制学生共36人,随机分配至观察组与对照组,每组各有18名学生。以卵巢恶性肿瘤为教学内容,观察组采用MDT模式结合TPS教学法,对照组采用传统教学方法。学习结束后,通过试卷考核及教学满意度问卷调查来了解36名同学的学习效果和教学满意度,并通过对比分析来判断教学效果及教学满意度。在试卷考核中,观察组学生在理论题、病案分析题的得分及总成绩上均明显优于对照组,差异具有统计学意义(P均<0.05)。在教学满意度问卷调查中,观察组同学在提高学习兴趣、提高自学能力、提高临床适应能力、多学科知识运用能力以及愿意继续接受该教学模式等方面的满意度均高于对照组(P均<0.05)。 展开更多
关键词 多学科协作诊疗 tps教学 妇科肿瘤
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葡萄TPS基因家族全基因组鉴定及VvTPS4在单萜形成中的功能验证 被引量:1
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作者 杨彩丽 李永洲 +5 位作者 贺亮亮 宋银花 章鹏 刘肇先 李鹏慧 刘三军 《中国农业科学》 北大核心 2025年第7期1397-1417,共21页
【目的】基于葡萄基因组信息,通过生物信息学手段对葡萄TPS基因家族成员进行鉴定及表达分析,为后续VvTPSs的生物学功能研究和葡萄育种提供科学依据。【方法】根据拟南芥AtTPS基因家族成员蛋白序列和TPS对应的隐尔马可夫文件PF01397和PF0... 【目的】基于葡萄基因组信息,通过生物信息学手段对葡萄TPS基因家族成员进行鉴定及表达分析,为后续VvTPSs的生物学功能研究和葡萄育种提供科学依据。【方法】根据拟南芥AtTPS基因家族成员蛋白序列和TPS对应的隐尔马可夫文件PF01397和PF03936,对VvTPS基因家族进行鉴定。利用Expasy、TBtools、MEME、MEGA、MCScanX、SPOMA、WoLF PSORT和PlantCARE等工具分析家族成员的理化性质、系统进化树、染色体定位、基因结构、蛋白质二级结构、启动子顺式作用元件和预测亚细胞定位。运用qPCR分析基因家族成员在无香型(‘红地球’)和玫瑰香型(‘玫瑰香’)葡萄成熟果实中的表达情况,并通过番茄转基因功能验证,分析转基因番茄果实挥发性代谢组学,以明确VvTPS4在单萜生物合成方面的功能。【结果】鉴定获得65个VvTPS基因家族成员,编码蛋白的氨基酸数目为339—840,平均分子质量为64.13 kDa,理论等电点为4.93—7.65,大多数成员具有7个外显子结构。经系统进化树分析,将葡萄TPS家族划分为TPS-a、TPS-b、TPS-c、TPS-e/f和TPS-g亚家族。VvTPS成员多定位于叶绿体和细胞质,其中,定位于质体的成员有10个属于TPS-g亚家族。在启动子区域发现含有大量响应光照、温度、干旱、激素和防御相关的顺式作用元件。克隆到29个VvTPSs,绝大多数VvTPSs在玫瑰香型葡萄果实中的表达高于无香型葡萄果实。转基因结果表明,过表达VvTPS4能够增加番茄果实中挥发性单萜物质的积累,其中,芳樟醇是最显著上调的化合物,是野生型的20.73倍,其次是L-α-松油醇(14.55倍),风味特征分析表明,这两种物质具有花香味,是影响‘玫瑰香’香气的主要特征物质。【结论】从葡萄基因组中鉴定到65个VvTPSs,成员之间具有高度的保守性,且在不同香气类型的葡萄中表达模式不同。过表达VvTPS4能显著增加挥发性单萜物质的积累,可能与玫瑰香气形成密切相关。 展开更多
关键词 葡萄 tps基因家族 表达分析 香气 代谢组学
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紫花含笑TPS基因家族鉴定及与萜烯类物质代谢关系分析
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作者 及浩楠 肖宇光 +4 位作者 牛小云 张志龙 刘军 姜景民 刁姝 《林业科学研究》 北大核心 2025年第3期29-38,共10页
[目的]探究紫花含笑花朵萜烯类物含量和TPS基因家族表达模式的相关性,为解析萜烯类物质合成途径的关键基因提供重要参考。[方法]基于紫花含笑无参转录组数据,采用生物信息学方法鉴定紫花含笑TPS基因家族成员,并对基因家族成员进行理化... [目的]探究紫花含笑花朵萜烯类物含量和TPS基因家族表达模式的相关性,为解析萜烯类物质合成途径的关键基因提供重要参考。[方法]基于紫花含笑无参转录组数据,采用生物信息学方法鉴定紫花含笑TPS基因家族成员,并对基因家族成员进行理化性质、保守基序及系统进化分析;利用实时荧光定量PCR技术揭示不同发育时期TPS基因表达模式,并结合顶空固相微萃取和气相色谱-质谱联用技术获取的不同发育阶段萜烯类物质含量,分析TPS基因表达和萜类物质含量的变化关系。[结果]本研究共鉴定到10个TPS成员,其编码氨基酸数量在511~987 aa,蛋白分子质量在57810.20~113803.45 Da。系统进化分析结果显示,紫花含笑TPS基因家族分为3个基因亚家族,TPS-e/f基因亚家族成员缺少Motif 1、Motif 3、Motif 5,TPS-b基因亚家族成员C41348.3缺少Motif 3,其余TPS基因含有6个Motif。C41348.6、C41348.3在时期Ⅴ显著性高表达,C31983.0和C40582.0在时期Ⅴ高表达。甜香型物质Α-罗勒烯、α-石竹烯、罗勒烯、卡地那二烯在时期IV含量上升,甜香型物质β-榄香烯、α-石竹烯、δ-榄香烯在时期V含量上升。对基因表达量变化与萜烯类物质含量变化进行相关性分析,紫花含笑TPS-b基因亚家族成员C41348.3和C41348.6均与单萜1,2-二[(E)-丙-1-烯基]环丁烷合成正相关。紫花含笑TPS-e/f基因亚家族中的C31983.0与3种甜果香型物质正相关。[结论]Α-罗勒烯、α-石竹烯、罗勒烯、卡地那二烯这几种甜果香型物质可能与紫花含笑时期IV花的果香形成有关。β-榄香烯、α-石竹烯、δ-榄香烯这几种甜果香型物质可能与紫花含笑时期V花的果香形成有关。C41348.6和C41348.3可能与成分1,2-二[(E)-丙-1-烯基]环丁烷合成有关。C31983.0可能参与调控紫花含笑甜果香型物质β-榄香烯、δ-榄香烯、α-石竹烯的形成。TPS基因家族可能在萜烯类物质的合成过程中发挥作用。本研究对紫花含笑TPS基因家族成员进行了深入挖掘,为未来探索紫花含笑花朵中重要萜类成分合成的关键基因功能提供理论基础。 展开更多
关键词 紫花含笑 生物信息学 tps基因家族 表达分析 挥发性萜类物质
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莲萜类合成酶(TPS)基因家族鉴定与分析
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作者 秦莉莉 杨宁宁 +4 位作者 张晨 唐佳伟 邓开宇 张克轩 董臣 《分子植物育种》 北大核心 2025年第4期1278-1284,共7页
萜类化合物是植物界中数量最多的天然代谢物,具有多种重要的生物学功能,萜类合成酶(terpenoid synthase,TPS)在萜类物质合成中起着关键作用。莲(Nelumbo nucifera)是中国重要的药食两用的植物,关于其萜类物质及TPS基因家族的研究相对较... 萜类化合物是植物界中数量最多的天然代谢物,具有多种重要的生物学功能,萜类合成酶(terpenoid synthase,TPS)在萜类物质合成中起着关键作用。莲(Nelumbo nucifera)是中国重要的药食两用的植物,关于其萜类物质及TPS基因家族的研究相对较少,本研究利用生物信息学技术鉴定莲的TPS基因家族,并分析了其基因结构、保守结构域、理化性质、蛋白质结构、基因表达特性等。结果表明,莲的TPS家族共有8个成员,分别命名为NnTPS01~NnTPS08。NnTPSs分为4个亚族,分布在3条染色体上,且均含有1个TPS和1个TPP结构域。理化性质分析表明,莲的TPS家族成员编码的蛋白均为酸性亲水蛋白。二级结构预测显示莲TPS基因家族编码的蛋白均以α-螺旋和无规卷曲为主。有6个蛋白亚细胞定位于叶绿体。顺式作用元件分析发现NnTPSs含有多种生物与非生物胁迫的作用元件。基因表达特性分析显示有7个基因可以表达,有5个基因在叶中表达量出现了上调,并且发现大多数基因在茎中都不表达。本研究结果为后续研究莲TPS基因家族功能特性提供科学依据。 展开更多
关键词 萜类化合物 tps基因家族 生物信息学 基因表达
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TPS教学模式在新护士门诊轮转培训中的应用
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作者 冯丽菲 朱晓秋 +2 位作者 沈莹 张苗苗 金琳娜 《中国高等医学教育》 2025年第8期145-146,F0003,共3页
目的:探讨TPS教学模式在新护士门诊轮转培训中的应用效果。方法:选择我院参加门诊轮转的166名新护士作为研究对象,2021年9~12月期间轮转的83名新护士为对照组,2022年1~4月期间轮转的83名新护士为试验组。对照组采用常规教学模式,试验组... 目的:探讨TPS教学模式在新护士门诊轮转培训中的应用效果。方法:选择我院参加门诊轮转的166名新护士作为研究对象,2021年9~12月期间轮转的83名新护士为对照组,2022年1~4月期间轮转的83名新护士为试验组。对照组采用常规教学模式,试验组采用TPS教学模式。对比两组培训满意度和人文执业能力。结果:试验组培训满意度和人文执业能力均高于对照组,差异具有统计学意义(P<0.05)。结论:TPS教学模式能够提高门诊轮转新护士的人文执业能力,具有一定的推广意义。 展开更多
关键词 tps教学模式 新护士 人文执业能力
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忍冬TPS基因家族鉴定及其在蚜虫危害下的表达分析
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作者 王刚 崔媛 +3 位作者 李启东 黄璐瑶 刘振华 李佳 《中国中药杂志》 北大核心 2025年第8期2116-2129,共14页
探究忍冬萜类合成酶(terpene synthase,TPS)基因家族成员的基本特征及其潜在功能。采用生物信息学方法对忍冬TPS基因家族进行鉴定和功能分析。结果表明,忍冬中LjTPS基因家族共鉴定出70个成员,蛋白长度在130~1437 aa,多为亲水性蛋白,不... 探究忍冬萜类合成酶(terpene synthase,TPS)基因家族成员的基本特征及其潜在功能。采用生物信息学方法对忍冬TPS基因家族进行鉴定和功能分析。结果表明,忍冬中LjTPS基因家族共鉴定出70个成员,蛋白长度在130~1437 aa,多为亲水性蛋白,不均匀地分布于9条染色体上。系统发育分析显示LjTPS基因家族成员分为6个亚族,主要为TPS-a、TPS-b和TPS-e亚族成员。启动子顺式作用元件分析表明LjTPS成员含有大量响应胁迫的顺式作用元件。通过蚜虫接种实验发现忍冬在蚜虫危害下萜类化合物骨架合成MVA途径关键酶基因HMGS、HMGR、MK、MPD和DXP途径关键酶基因DXS均呈现先增后降的趋势。qRT-PCR结果显示α-法尼烯合成酶基因LjTPS34和LjTPS39表达量下调;(E)-β-石竹烯合成酶基因LjTPS15和LjTPS17的表达量在取食前12 h上调,随后开始下降。与之有相互作用的法尼基焦磷酸合酶FPS亦呈先增后降的趋势。芳樟醇合成酶基因LjTPS12和LjTPS33的表达量在蚜虫取食72 h后显著上调(P<0.0001),分别可达初始表达量的24.39、22.64倍,与忍冬芳樟醇相对含量的趋势基本一致。该研究为后续忍冬与害虫的相互作用及LjTPS基因家族的功能研究提供理论基础。 展开更多
关键词 忍冬 萜类合成酶(tps) 生物信息学分析 蚜虫胁迫
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血清Her-2-ECD、TPS水平与Her-2阳性乳腺癌曲妥珠单抗敏感性的相关性
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作者 陈柯 牛萍 王芳 《实用癌症杂志》 2025年第1期9-12,共4页
目的探讨血清Her-2-ECD、TPS水平与Her-2阳性乳腺癌曲妥珠单抗敏感性的关系。方法选取Her-2阳性乳腺癌患者100例,均接受曲妥珠单抗治疗,根据RECIST1.1标准评价疗效,将CR+PR纳入敏感组,SD+PD纳入耐药组。同时期选取健康人群30名纳入对照... 目的探讨血清Her-2-ECD、TPS水平与Her-2阳性乳腺癌曲妥珠单抗敏感性的关系。方法选取Her-2阳性乳腺癌患者100例,均接受曲妥珠单抗治疗,根据RECIST1.1标准评价疗效,将CR+PR纳入敏感组,SD+PD纳入耐药组。同时期选取健康人群30名纳入对照组。比较3组血清Her-2-ECD、TPS水平。分析Her-2-ECD、TPS水平与乳腺癌患者临床病理参数和疗效的关系。结果CR+PR共79例,SD+PD共21例。3组血清Her-2-ECD、TPS水平比较,差异有统计学意义(P<0.05),其中耐药组血清Her-2-ECD、TPS水平最高,敏感组次之,对照组最低。不同组织学分级、肿瘤转移部位数量患者血清Her-2-ECD、TPS水平比较,差异有统计学意义(P<0.05);不同年龄、月经状态、ECOG评分患者血清Her-2-ECD、TPS水平比较,差异无统计学意义(P>0.05)。血清Her-2-ECD、TPS水平联合预测靶向治疗疗效灵敏度84.69%、特异度78.49%、AUC 0.841,均较单一检测更高(P<0.05)。耐药组中血清Her-2-ECD>41.55 ng/ml、血清TPS>118.47 U/L的患者占比均高于敏感组(P<0.05)。结论血清Her-2-ECD、TPS水平与Her-2阳性乳腺癌患者对曲妥珠单抗治疗的敏感性具有一定关系,联合检测可以提高对靶向治疗疗效的预测能力。 展开更多
关键词 乳腺癌 HER-2阳性 Her-2-ECD tps 曲妥珠单抗 敏感性
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加工温度对PBAT/TPS共混体系性能的影响 被引量:3
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作者 李宇飞 《化工管理》 2025年第2期140-143,共4页
聚对苯二甲酸-己二酸-丁二醇酯(PBAT)与热塑性淀粉(TPS)共混,可降低PBAT的自身成本,同时增强其机械性能。PBAT与TPS对温度均较为敏感,适当的加工温度可以促进聚酯材料在吹膜过程中的流动性和成型性,进而影响材料制品的性能。文章在相同... 聚对苯二甲酸-己二酸-丁二醇酯(PBAT)与热塑性淀粉(TPS)共混,可降低PBAT的自身成本,同时增强其机械性能。PBAT与TPS对温度均较为敏感,适当的加工温度可以促进聚酯材料在吹膜过程中的流动性和成型性,进而影响材料制品的性能。文章在相同配方、不同温度下进行加工改性、挤出、吹塑成膜以及注塑成条后,并对共混体系进行力学性能、结晶行为、热变形温度和维卡软化点分析对比。结果表明,当双螺杆挤出机加工温度为140℃时,共混切片的熔融温度(Tm)最高,有利于结晶成核以及共混体系分子链的重新排布,从而加快结晶速度;共混切片的结晶起始温度也最高,在该加工温度下,结晶过程更缓慢,稳定性更强,且拉伸强度、断裂伸长率等力学性能最优。 展开更多
关键词 聚对苯二甲酸-己二酸-丁二醇酯(PBAT) 热塑性淀粉(tps) 拉伸强度 结晶行为 温度
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TPS教学模式在基础化学课程教学中的实践探究——以碱金属教学设计为例 被引量:1
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作者 王丽霞 李敏 +2 位作者 吴晓燕 叶东 梁仕健 《邢台学院学报》 2025年第2期151-158,共8页
完备的化学知识对地理科学专业后续课程的学习具有重要作用,但生源多元化带来的学情差异给基础化学的教学带来巨大困难。以碱金属的教学设计为例,将TPS教学模式引入课程中,旨在帮助拥有不同教育背景的学生学习好基础化学,提高学生对化... 完备的化学知识对地理科学专业后续课程的学习具有重要作用,但生源多元化带来的学情差异给基础化学的教学带来巨大困难。以碱金属的教学设计为例,将TPS教学模式引入课程中,旨在帮助拥有不同教育背景的学生学习好基础化学,提高学生对化学学习的积极性与自主性,增强学生的学习自信,最终实现基础化学的有效教学和学生综合化学素质的“双提升”。成绩数据对比分析及调查问卷统计表明,这种教学方法对地理科学专业中的基础化学教学有积极意义。 展开更多
关键词 tps教学模式 拼图游戏教学法 地理科学 化学
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TPS联合PCMC模式在中医外科学临床教学的应用
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作者 韩娜娜 尹戈 +2 位作者 孙道永 王海水 任东 《中国中医药现代远程教育》 2025年第4期7-9,共3页
目的 观察思考-交流-分享(Think-pair-share,TPS)联合启发式临床医学课程(Problem-originated clinical medical curriculum,PCMC)教学模式在中医外科临床教学中的应用效果。方法 选取日照市中医医院外科/血管外科2021年1月—2021年12... 目的 观察思考-交流-分享(Think-pair-share,TPS)联合启发式临床医学课程(Problem-originated clinical medical curriculum,PCMC)教学模式在中医外科临床教学中的应用效果。方法 选取日照市中医医院外科/血管外科2021年1月—2021年12月接收的42名实习生为对照组,采用传统教学法;2022年1月—2022年12月接收的40名实习生为研究组,采用TPS联合PCMC教学模式。观察两组学习效果,自制“一分钟问卷”评估教学效果。结果 研究组理论考核和临床技能考核成绩均明显高于对照组(P<0.05)。调查问卷显示,研究组在学习能力、激发热情、人文关怀、思维拓展、团队协作、临床能力、技能操作和总体印象方面均优于对照组(P<0.05)。结论 应用TPS联合PCMC教学模式可发挥互动式、主动性学习的优势,能显著提高学生的临床学习和适应能力。 展开更多
关键词 中医外科 思考-交流-分享 启发式临床医学课程教学模式 临床教学
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PLC transition sequence identification based on logical reduction 被引量:1
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作者 Yue Luo Jianhong Ye +2 位作者 Jiazhong Zhou Jia Liu Linping Jiang 《Control Theory and Technology》 2025年第4期672-687,共16页
In industrial control systems,such as power transmission facilities and water treatment plants,Programmable Logic Controllers(PLCs)can work consistently and stably over long periods if there are no faults.Black-box id... In industrial control systems,such as power transmission facilities and water treatment plants,Programmable Logic Controllers(PLCs)can work consistently and stably over long periods if there are no faults.Black-box identification aims to automatically construct Petri net models with the help of I/O signals from PLC devices only.The main challenge is how to convert the infinitely long PLC signals into an event sequence,which is the foundation for subsequent modeling.The current algorithms are confronted with a number of challenges,including an exponential increase in the number of transitions,high time complexity,and susceptibility to noisy signals.To solve these problems,this paper proposes a new method for converting PLC signals into a transition sequence.The method is based on the principles of Boolean absorption law,which filters out noise information in the I/O signals.Then firing functions representing input–output causality are constructed from the filtered signals.Finally,the original signal sequence is traversed to generate a transition sequence.The experimental results show that these methods can rapidly identify a transition sequence.Compared to traditional methods,the proposed algorithms have polynomial time complexity. 展开更多
关键词 PLC Boolean logic Transition sequence Petri net
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Relationship between pore throat structure and crude oil mobility of full particle sequence reservoirs in Permian Fengcheng Formation,Mahu Sag,Junggar Basin,NW China 被引量:4
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作者 TANG Yong JIA Chengzao +8 位作者 CHEN Fangwen HE Wenjun ZHI Dongming SHAN Xiang YOU Xincai JIANG Lin ZOU Yang WU Tao XIE An 《Petroleum Exploration and Development》 2025年第1期112-124,共13页
Based on the experimental results of casting thin section,low temperature nitrogen adsorption,high pressure mercury injection,nuclear magnetic resonance T2 spectrum,contact angle and oil-water interfacial tension,the ... Based on the experimental results of casting thin section,low temperature nitrogen adsorption,high pressure mercury injection,nuclear magnetic resonance T2 spectrum,contact angle and oil-water interfacial tension,the relationship between pore throat structure and crude oil mobility characteristics of full particle sequence reservoirs in the Lower Permian Fengcheng Formation of Mahu Sag,Junggar Basin,are revealed.(1)With the decrease of reservoir particle size,the volume of pores connected by large throats and the volume of large pores show a decreasing trend,and the distribution and peak ranges of throat and pore radius shift to smaller size in an orderly manner.The upper limits of throat radius,porosity and permeability of unconventional reservoirs in Fengcheng Formation are approximately 0.7μm,8%and 0.1×10^(−3)μm^(2),respectively.(2)As the reservoir particle size decreases,the distribution and peak ranges of pores hosting retained oil and movable oil are shifted to a smaller size in an orderly manner.With the increase of driving pressure,the amount of retained and movable oil of the larger particle reservoir samples shows a more obvious trend of decreasing and increasing,respectively.(3)With the increase of throat radius,the driving pressure of reservoir with different particle levels presents three stages,namely rapid decrease,slow decrease and stabilization.The oil driving pressures of various reservoirs and the differences of them decrease with the increase of temperature and obviously decrease with the increase of throat radius.According to the above experimental analysis,it is concluded that the deep shale oil of Fengcheng Formation in Mahu Sag has great potential for production under geological conditions. 展开更多
关键词 Junggar Basin Mahu Sag Lower Permian Fengcheng Formation full particle sequence reservoir pore throat structure crude oil mobility whole petroleum system
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Detailed oil-source correlation within the sequence and sedimentary framework in the Fushan Depression,Beibuwan Basin,South China Sea 被引量:1
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作者 Xin Wang Mei-Jun Li +3 位作者 Yang Shi Hao Guo Bang Zeng Xi He 《Petroleum Science》 2025年第1期90-109,共20页
The Fushan Depression is one of the petroliferous depressions in the Beibuwan Basin,South China Sea.Previous studies have preliminarily explored the origin and source of crude oils in some areas of this depression.Nev... The Fushan Depression is one of the petroliferous depressions in the Beibuwan Basin,South China Sea.Previous studies have preliminarily explored the origin and source of crude oils in some areas of this depression.Nevertheless,no systematic investigations on the classification and origin of oils and hy-drocarbon migration processes have been made for the entire petroleum system in this depression,which has significantly hindered the hydrocarbon exploration in the region.A total of 32 mudstone and 58 oil samples from the Fushan Depression were analyzed to definite the detailed oil-source correlation within the sequence and sedimentary framework.The organic matter of third member of Paleogene Liushagang Formation(Els(3))source rocks,both deltaic and lacustrine mudstone,are algal-dominated with high abundance of C_(23)tricyclic terpane and C_(30)4-methylsteranes.The deltaic source rocks occur-ring in the first member(Els_(1))and second member(Els_(2))of the Paleogene Liushagang Formation are characterized by high abundance of C_(19+20)tricyclic terpane and oleanane,reflecting a more terrestrial plants contribution.While lacustrine source rocks of Els_(1)and Els_(2)display the reduced input of terrige-nous organic matter with relatively low abundance of C 19+20 tricyclic terpane and oleanane.Three types of oils were identified by their biomarker compositions in this study.Most of the oils discovered in the Huachang and Bailian Els_(1)reservoir belong to group A and were derived from lacustrine source rocks of Els_(1)and Els_(2).Group B oils are found within the Els_(1)and Els_(2)reservoirs,showing a close relation to the deltaic source rocks of Els_(1)and Els_(2),respectively.Group C oils,occurring in the Els3 reservoirs,have a good affinity with the Els3 source rocks.The spatial distribution and accumulation of different groups of oils are mainly controlled by the sedimentary facies and specific structural conditions.The Els_(2)reservoir in the Yong'an area belonging to Group B oil,are adjacent to the source kitchen and could be considered as the favorable exploration area in the future. 展开更多
关键词 Oil-source correlation sequence stratigraphic framework Biomarkers Fushan depression South China Sea
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