The serum of foxes and red deer from the Province of Soria (northern Spain) was screened in indirect immunofluorescence assays to determine whether these animals could be used as sentinels of the tick-borne pathogens ...The serum of foxes and red deer from the Province of Soria (northern Spain) was screened in indirect immunofluorescence assays to determine whether these animals could be used as sentinels of the tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis. The results suggest that foxes and red deer would not make good sentinels in epidemiological studies on E. chaffeensis in this region, although red deer could be used as such for the study of A. phagocytophilum transmission.展开更多
城市空间发展易受地形所限,削山造地能克服土地资源稀缺,成为解决城市空间拓展最为直接的途径。该方法利用遥感技术快速准确获取削山造地范围信息,对区域生态环境科学评估和新城发展规划具有十分重要的意义。本文基于GEE遥感云计算平台...城市空间发展易受地形所限,削山造地能克服土地资源稀缺,成为解决城市空间拓展最为直接的途径。该方法利用遥感技术快速准确获取削山造地范围信息,对区域生态环境科学评估和新城发展规划具有十分重要的意义。本文基于GEE遥感云计算平台,利用Sentinel-1合成孔径雷达(synthetic aperture Rader,SAR)数据,采用组合升、降轨影像,在噪声滤除和多时相影像合成的基础上,计算削山造地前后后向散射强度的差值,并采用百分位阈值法结合样本数据确定阈值,提取研究区2017—2022年削山造地开挖区时空分布;然后联合SAR和光学数据的光谱特征、纹理特征和地形特征,在特征优化的基础上结合随机森林算法获取了2017—2022年逐年削山造地范围时空分布。研究结果表明:①提取的开挖区范围总体分类精度和Kappa系数分别达85%和0.83。②研究期间,发现2019年前开挖区主要集中在九州开发区、碧桂园和保利领秀山,2020年以后新增加了刘家沟、水源站等开挖区,开挖范围和强度逐渐增大。③2018年前造地规模较小,面积为2.655 km 2;2019年以后造地规模逐年增大,特别是2021年,其造地面积达12.607 km 2,占监测期间总造地面积的34.56%,2022年在原造地基础上开挖,因坡度和开挖量逐渐增大,造地面积仅2.686 km 2。本文构建的削山造地开挖区监测和造地范围提取方法可有效获取削山和造地范围快速监测与提取。展开更多
The principal breast cancer treatment approach has long been surgical removal of the primary breast lesions and regional lymph nodes,particularly the axillary lymph nodes.However,the advent of minimally invasive diagn...The principal breast cancer treatment approach has long been surgical removal of the primary breast lesions and regional lymph nodes,particularly the axillary lymph nodes.However,the advent of minimally invasive diagnostic techniques,such as sentinel lymph node biopsy(SLNB),has markedly diminished the extent of surgery required for regional lymph nodes.展开更多
Land cover changes significantly affect mangrove forests,driven by both anthropogenic activities and natural processes.The Banlaem mangrove in Nakhon Si Thammarat,Thailand,supports numerous mangrove plantation project...Land cover changes significantly affect mangrove forests,driven by both anthropogenic activities and natural processes.The Banlaem mangrove in Nakhon Si Thammarat,Thailand,supports numerous mangrove plantation projects but lacks comprehensive assessments and monitoring related to land cover changes.This study aimed to(1)investigate land cover changes in the Banlaem mangrove from 1995 to 2023,and(2)generate a predictive model for future land cover changes.For land cover assessment,satellite imagery from multiple sources,including Sentinel-2(Level 2A)and Landsat(Collection 2 Level 2),was utilized to examine and classify changes in mangrove cover within the Banlaem mangrove forest from 1995 to 2023,using supervised classification with the maximum likelihood algorithm.Various regression models were analysed to develop a predictive model based on area size and time.The mangrove area in the Banlaem mangrove forest steadily grew throughout the study period,with the total area increasing from 56.16 ha in 1995 to 527.55 ha in 2023.This study represents the first analysis of changes in the Banlaem mangrove cover.Throughout the tested models,they reveal an unclear pattern of mangrove expansion,yet they indicate a high rate of expansion in the Banlaem mangrove forest.In addition,these results are expected to encourage greater community involvement in the monitoring and management of the Banlaem mangrove.We recommend establishing a community monitoring network to engage local residents in tracking changes in mangrove cover,supported by training and resources.展开更多
Introduction The accuracy of sentinel lymph node biopsy(SLNB)after neoadjuvant therapy(NAT)has been confirmed in clinical nodal stage 1(c N1)patients,and more patients could benefit from axillary surgery de-escalation...Introduction The accuracy of sentinel lymph node biopsy(SLNB)after neoadjuvant therapy(NAT)has been confirmed in clinical nodal stage 1(c N1)patients,and more patients could benefit from axillary surgery de-escalation after NAT(1,2).展开更多
Objective Almost 15%of prostate cancer(PCa)patients were found to have lymph node metastases(LNMs),which are associated with higher risk of biochemical recurrence.Using indocyanine green(ICG)for the sentinel node biop...Objective Almost 15%of prostate cancer(PCa)patients were found to have lymph node metastases(LNMs),which are associated with higher risk of biochemical recurrence.Using indocyanine green(ICG)for the sentinel node biopsy(SNB)before surgery was proposed to detect LNMs in PCa patients.However,its diagnostic performance still remains controversial.This study aimed to investigate the diagnostic performance of ICG for the SNB in PCa.Methods This systematic review and meta-analysis has been reported in line with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.The protocol has been registered in the International Prospective Register of Systematic Reviews database,and the register number is CRD42023421911.Four bibliographic databases were searched,i.e.,PubMed,EMBASE,Cochrane Library,and Web of Science,to retrieve articles studying the diagnostic performance of ICG for the SNB in PCa from the inception to Sep 9,2023.We calculated the pooled sensitivity,specificity,likelihood ratios,diagnostic odds ratios and their 95%confidence intervals(CIs).Subgroup analyses and meta-regression analyses were also conducted.Results A total of 17 articles from databases are enrolled in this study.Using lymph node-based data,our results showed that the pooled sensitivity and specificity of applying ICG alone in PCa were 71%(95%CI 52%–85%)and 68%(95%CI 64%–72%),respectively.The pooled sensitivity and specificity of applying ICG-technetium-99m-nanocolloid in PCa were 49%(95%CI 39%–59%)and 69%(95%CI 67%–71%),respectively.展开更多
Background:3-field lymph node dissection(3FL)frequently lead to much more perioperative complications than 2-field lymph node dissection(2FL).This study was designed as a non-inferiority trial to evaluate whether 3FL ...Background:3-field lymph node dissection(3FL)frequently lead to much more perioperative complications than 2-field lymph node dissection(2FL).This study was designed as a non-inferiority trial to evaluate whether 3FL could be omitted without compromising overall survival(OS)and disease-free survival(DFS)in the patients with resectable thoracic esophageal squamous cell cancer(ESCC)and negative right recurrent laryngeal nerve lymph nodes(RRLN-LNs).Methods:cT1b-3N0-1M0 thoracic ESCC patients were managed in 3 arms during open or minimally invasive McKeown esophagectomy according to the results of frozen section examination for RRLN-LNs:if positive,direct 3FL(RRLN[+]-3FL);if negative,2FL(RRLN[-]-2FL)or 3FL(RRLN[-]-3FL)by randomization.Results:Based on frozen section,of the 829 finally recruited patients,121(13.6%)had positive RRLN-LNs and direct 3FL(RRLN[+]-3FL);766 had negative RRLN-LNs and were randomized into the RRLN[-]-2FL(386 cases)or RRLN[-]-3FL(380 cases)group.The cervical LN metastasis rate in the RRLN[+]-3FL group(28.9%)was significantly higher than that in the RRLN[-]-3FL group(8.3%)(P<0.001).The 5-year OS and DFS were 72.2%and 65.1%in the RRLN[-]-3FL group and 68.8%and 62.8%in the RRLN[-]-2FL group(OS,P=0.163;DFS,P=0.378),versus 50.3%and 41.2%in the RRLN[+]-3FL group(both P<0.001),respectively.Conclusions:Additional cervical lymphadenectomy can be avoided in the patients with middle or lower thoracic ESCC and negative RRLN-LNs by frozen section treated by upfront surgery.展开更多
Dear Editor,Since 2024,the clade 2.3.4.4b highly pathogenic avian influenza(HPAI)H5N1 viruses have been identified in dairy cattle in the United States,raising global concerns about public health(Neumann and Kawaoka,2...Dear Editor,Since 2024,the clade 2.3.4.4b highly pathogenic avian influenza(HPAI)H5N1 viruses have been identified in dairy cattle in the United States,raising global concerns about public health(Neumann and Kawaoka,2024).As of December 18,2024,the U.S.Centers for Disease Control and Prevention(CDC)has reported over 61 confirmed cases of H5N1 infection in humans,predominantly associated with exposure to infected poultry or dairy cattle(U.S.Centers for Disease Control and Prevention,2024).Notably,the circulating 2.3.4.4b H5N1 clade has demonstrated continuous evolution in both wild and domestic birds globally,with expanding mammalian host tropism that now includes swine,cats,red foxes,harbor seals,and skunks(Peacock et al.,2024).These viruses have not only incurred substantial economic impacts but also posed dual threats to human health and ecological stability particularly during co-infections with other viruses(Abolnik,2024;Wang and Wang,2023).展开更多
文摘The serum of foxes and red deer from the Province of Soria (northern Spain) was screened in indirect immunofluorescence assays to determine whether these animals could be used as sentinels of the tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis. The results suggest that foxes and red deer would not make good sentinels in epidemiological studies on E. chaffeensis in this region, although red deer could be used as such for the study of A. phagocytophilum transmission.
文摘城市空间发展易受地形所限,削山造地能克服土地资源稀缺,成为解决城市空间拓展最为直接的途径。该方法利用遥感技术快速准确获取削山造地范围信息,对区域生态环境科学评估和新城发展规划具有十分重要的意义。本文基于GEE遥感云计算平台,利用Sentinel-1合成孔径雷达(synthetic aperture Rader,SAR)数据,采用组合升、降轨影像,在噪声滤除和多时相影像合成的基础上,计算削山造地前后后向散射强度的差值,并采用百分位阈值法结合样本数据确定阈值,提取研究区2017—2022年削山造地开挖区时空分布;然后联合SAR和光学数据的光谱特征、纹理特征和地形特征,在特征优化的基础上结合随机森林算法获取了2017—2022年逐年削山造地范围时空分布。研究结果表明:①提取的开挖区范围总体分类精度和Kappa系数分别达85%和0.83。②研究期间,发现2019年前开挖区主要集中在九州开发区、碧桂园和保利领秀山,2020年以后新增加了刘家沟、水源站等开挖区,开挖范围和强度逐渐增大。③2018年前造地规模较小,面积为2.655 km 2;2019年以后造地规模逐年增大,特别是2021年,其造地面积达12.607 km 2,占监测期间总造地面积的34.56%,2022年在原造地基础上开挖,因坡度和开挖量逐渐增大,造地面积仅2.686 km 2。本文构建的削山造地开挖区监测和造地范围提取方法可有效获取削山和造地范围快速监测与提取。
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.81672638 and W2421095)National Natural Science Foundation of Shandong Province(Grant No.ZR2024LMB011)Collaborative Academic Innovation Project of Shandong Cancer Hospital(Grant No.GF003)。
文摘The principal breast cancer treatment approach has long been surgical removal of the primary breast lesions and regional lymph nodes,particularly the axillary lymph nodes.However,the advent of minimally invasive diagnostic techniques,such as sentinel lymph node biopsy(SLNB),has markedly diminished the extent of surgery required for regional lymph nodes.
文摘Land cover changes significantly affect mangrove forests,driven by both anthropogenic activities and natural processes.The Banlaem mangrove in Nakhon Si Thammarat,Thailand,supports numerous mangrove plantation projects but lacks comprehensive assessments and monitoring related to land cover changes.This study aimed to(1)investigate land cover changes in the Banlaem mangrove from 1995 to 2023,and(2)generate a predictive model for future land cover changes.For land cover assessment,satellite imagery from multiple sources,including Sentinel-2(Level 2A)and Landsat(Collection 2 Level 2),was utilized to examine and classify changes in mangrove cover within the Banlaem mangrove forest from 1995 to 2023,using supervised classification with the maximum likelihood algorithm.Various regression models were analysed to develop a predictive model based on area size and time.The mangrove area in the Banlaem mangrove forest steadily grew throughout the study period,with the total area increasing from 56.16 ha in 1995 to 527.55 ha in 2023.This study represents the first analysis of changes in the Banlaem mangrove cover.Throughout the tested models,they reveal an unclear pattern of mangrove expansion,yet they indicate a high rate of expansion in the Banlaem mangrove forest.In addition,these results are expected to encourage greater community involvement in the monitoring and management of the Banlaem mangrove.We recommend establishing a community monitoring network to engage local residents in tracking changes in mangrove cover,supported by training and resources.
文摘Introduction The accuracy of sentinel lymph node biopsy(SLNB)after neoadjuvant therapy(NAT)has been confirmed in clinical nodal stage 1(c N1)patients,and more patients could benefit from axillary surgery de-escalation after NAT(1,2).
文摘Objective Almost 15%of prostate cancer(PCa)patients were found to have lymph node metastases(LNMs),which are associated with higher risk of biochemical recurrence.Using indocyanine green(ICG)for the sentinel node biopsy(SNB)before surgery was proposed to detect LNMs in PCa patients.However,its diagnostic performance still remains controversial.This study aimed to investigate the diagnostic performance of ICG for the SNB in PCa.Methods This systematic review and meta-analysis has been reported in line with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.The protocol has been registered in the International Prospective Register of Systematic Reviews database,and the register number is CRD42023421911.Four bibliographic databases were searched,i.e.,PubMed,EMBASE,Cochrane Library,and Web of Science,to retrieve articles studying the diagnostic performance of ICG for the SNB in PCa from the inception to Sep 9,2023.We calculated the pooled sensitivity,specificity,likelihood ratios,diagnostic odds ratios and their 95%confidence intervals(CIs).Subgroup analyses and meta-regression analyses were also conducted.Results A total of 17 articles from databases are enrolled in this study.Using lymph node-based data,our results showed that the pooled sensitivity and specificity of applying ICG alone in PCa were 71%(95%CI 52%–85%)and 68%(95%CI 64%–72%),respectively.The pooled sensitivity and specificity of applying ICG-technetium-99m-nanocolloid in PCa were 49%(95%CI 39%–59%)and 69%(95%CI 67%–71%),respectively.
基金supported by National Science and Technology Sup-port Program(grant number:NKTRDP-2015BAI12B08-01).
文摘Background:3-field lymph node dissection(3FL)frequently lead to much more perioperative complications than 2-field lymph node dissection(2FL).This study was designed as a non-inferiority trial to evaluate whether 3FL could be omitted without compromising overall survival(OS)and disease-free survival(DFS)in the patients with resectable thoracic esophageal squamous cell cancer(ESCC)and negative right recurrent laryngeal nerve lymph nodes(RRLN-LNs).Methods:cT1b-3N0-1M0 thoracic ESCC patients were managed in 3 arms during open or minimally invasive McKeown esophagectomy according to the results of frozen section examination for RRLN-LNs:if positive,direct 3FL(RRLN[+]-3FL);if negative,2FL(RRLN[-]-2FL)or 3FL(RRLN[-]-3FL)by randomization.Results:Based on frozen section,of the 829 finally recruited patients,121(13.6%)had positive RRLN-LNs and direct 3FL(RRLN[+]-3FL);766 had negative RRLN-LNs and were randomized into the RRLN[-]-2FL(386 cases)or RRLN[-]-3FL(380 cases)group.The cervical LN metastasis rate in the RRLN[+]-3FL group(28.9%)was significantly higher than that in the RRLN[-]-3FL group(8.3%)(P<0.001).The 5-year OS and DFS were 72.2%and 65.1%in the RRLN[-]-3FL group and 68.8%and 62.8%in the RRLN[-]-2FL group(OS,P=0.163;DFS,P=0.378),versus 50.3%and 41.2%in the RRLN[+]-3FL group(both P<0.001),respectively.Conclusions:Additional cervical lymphadenectomy can be avoided in the patients with middle or lower thoracic ESCC and negative RRLN-LNs by frozen section treated by upfront surgery.
文摘Dear Editor,Since 2024,the clade 2.3.4.4b highly pathogenic avian influenza(HPAI)H5N1 viruses have been identified in dairy cattle in the United States,raising global concerns about public health(Neumann and Kawaoka,2024).As of December 18,2024,the U.S.Centers for Disease Control and Prevention(CDC)has reported over 61 confirmed cases of H5N1 infection in humans,predominantly associated with exposure to infected poultry or dairy cattle(U.S.Centers for Disease Control and Prevention,2024).Notably,the circulating 2.3.4.4b H5N1 clade has demonstrated continuous evolution in both wild and domestic birds globally,with expanding mammalian host tropism that now includes swine,cats,red foxes,harbor seals,and skunks(Peacock et al.,2024).These viruses have not only incurred substantial economic impacts but also posed dual threats to human health and ecological stability particularly during co-infections with other viruses(Abolnik,2024;Wang and Wang,2023).
