In a recent study published in Science Translational Medicine,Jiang et al.uncovered a novel contribution of sensory neuron-derived follistatin(FST)to neuropathic pain by which FST,generated from A-fiber neurons,promot...In a recent study published in Science Translational Medicine,Jiang et al.uncovered a novel contribution of sensory neuron-derived follistatin(FST)to neuropathic pain by which FST,generated from A-fiber neurons,promotes Nav 1.7-mediated noceptive neuronal excitability via binding to the insulin-like growth factor 1 receptor(IGF1R),making it a potential therapeutic target for neuropathic pain(Fig.1A,B)[1].展开更多
基金supported by the National Natural Science Foundation of China(82474625)Zhejiang Provincial Natural Science Funds(LZ23H270001).
文摘In a recent study published in Science Translational Medicine,Jiang et al.uncovered a novel contribution of sensory neuron-derived follistatin(FST)to neuropathic pain by which FST,generated from A-fiber neurons,promotes Nav 1.7-mediated noceptive neuronal excitability via binding to the insulin-like growth factor 1 receptor(IGF1R),making it a potential therapeutic target for neuropathic pain(Fig.1A,B)[1].
