Hyperactivation of DNA repairing pathway is highly associated with the chemosensitivity and chemoresistance of cancer cells.In this manuscript,guided by cascaded one strain many compounds-global natural products socia...Hyperactivation of DNA repairing pathway is highly associated with the chemosensitivity and chemoresistance of cancer cells.In this manuscript,guided by cascaded one strain many compounds-global natural products social molecular networking(OSMAC-GNPS)strategy,a pair of epimeric environmental-induced metabolites were isolated from Aspergillus sp.EGF 15-0-3.Structurally,sterpiperazines A(1)and B(2)represent the first steroid-based indole alkaloids with unprecedented backbones.Biologically,compound 1 could be identified as a novel tyrosyl-DNA phosphodiesterase 1(Tdp1)inhibitor with a unique mechanism distinct from the reported modulators,and was able to significantly enhance the sensitivity of NCI-H460 cells to the clinic chemotherapeutic drug through inhibiting the DNA repairment and enhanced the DNA damage of cancer cells.展开更多
In the presence of mixed micelle of a cationic and a nonionic surfactants,the reaction of scandium(Ⅲ) with phenylfluorone or its derivatives results in a very sensitive colouration:furthermore this chromophoric syste...In the presence of mixed micelle of a cationic and a nonionic surfactants,the reaction of scandium(Ⅲ) with phenylfluorone or its derivatives results in a very sensitive colouration:furthermore this chromophoric system tolerates the existence of a considerable amount of masking agents,so that many interfering ions can be masked and its selectivity would be further improved.After studying the optimum conditions and main charac- ters of some similar systems,the system of Sc(Ⅲ)—Orthonitrophenyuorone—Cetyltrimethylammonium Bromide(CTMAB)—Triton X-200 is chosen for the spectrophotometric determination of microamount of scandium.The proposed method shows not only high sensitivity(with a molar absorptivity of 2.12×1~sL mol^(-1)·cm^(-1))and selectivity,but also high tolerance of chromophoric conditions.Beer's law is obeyed over a range of 0～6.0 μg Sc/25ml.If the dual-wavelength method is applied,a much higher molar absorptivity o|' 3.04×10~5L·mol^(-1)·cm^(-1)than those of other systems ever reported in the literatures can be attained:more- over.its linear range is extended to 0～8.0 μg Sc/25ml and its reproducibility is also improved.展开更多
The long persistent phosphors of Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)with Nd^(3+)as sensitized ions and Tb^(3+)as emission centers were synthesized using high temperature solid state reaction.The crystal st...The long persistent phosphors of Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)with Nd^(3+)as sensitized ions and Tb^(3+)as emission centers were synthesized using high temperature solid state reaction.The crystal structure and defects,excitation and emission spectra,decay curves and thermoluminescence(TL) curves of the phosphors were investigated.The synthesized Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)is essentially in line with the standard card PDF#49-1079.The emission band with main peak at 548 nm exhibits the characteristic transitions of ^(5)D_(3)-^(7)F_(j)(j=5,4) and ^(5)D_(3)-^(7)F_(j)(j=6,5,4,3) of Tb^(3+).The analysis of excitation and emission spectra shows that there exists the overlap between the emission peaks of Nd^(3+)at 466 and 485 nm and the excitation of Tb^(3+)at 443 and 485 nm,and the energy transfer from Nd^(3+)to Tb^(3+)plays an important role in the improvement of luminescence properties.The decay curves shows that Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)has longer afterglow time than ZrP_(2)O_(7) and Zr_(0.982)P_(2)O_(7):0.018 Tb^(3+).Additionally,the TL curves indicate that the trap depth at 0.72 eV in Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)is to the benefit of the afterglow time.The possible luminescence mechanism of ZrP_(2)O_(7):Tb^(3+),Nd^(3+)is proposed on the basis of the XPS spectra,EPR spectra,excitation and emission spectra,decay curves,TL curves and the analysis of defect equations.展开更多
Combining hyperthermia and chemotherapy for maximum anticancer efficacy remains a challenge because drugtolerant cancer cells often evade this synergistic treatment due to drug resistance and asynchronous drug release...Combining hyperthermia and chemotherapy for maximum anticancer efficacy remains a challenge because drugtolerant cancer cells often evade this synergistic treatment due to drug resistance and asynchronous drug release.In this study,multifunctional scaffolds were designed to efficiently treat drug-tolerant breast cancer by improving the sensitization of breast cancer cells and synchronizing anticancer drug release with magnetic hyperthermia.The scaffolds contained microRNA-encapsulated matrix metalloproteinase-cleavable liposomes,doxorubicin-encapsulated thermoresponsive liposomes and Fe_(3)O_(4)nanoparticles.The scaffolds could release microRNA specifically to improve the sensitization of breast cancer cells to anticancer drugs.The scaffolds also showed excellent hyperthermia effects under alternating magnetic field irradiation.Moreover,doxorubicin release was synchronized with magnetic hyperthermia.In vitro and in vivo studies demonstrated that the scaffolds effectively reduced drug resistance and eliminated doxorubicin-tolerant MDA-MB-231 cells through the syner-gistic effect of magnetic hyperthermia and sensitizing chemotherapy.Additionally,the scaffolds could support the proliferation and adipogenic differentiation of stem cells for adipose tissue regeneration after killing cancer cells at a late therapeutic stage.These composite scaffolds offer an innovative strategy for treating breast cancer,with synergistic anticancer effects and regenerative functions.展开更多
Radiotherapy(RT)is one of the most feasible and routinely used therapeutic modalities for treating malignant tumors.In particular,immune responses triggered by RT,known as radio-immunotherapy,can partially inhibit the...Radiotherapy(RT)is one of the most feasible and routinely used therapeutic modalities for treating malignant tumors.In particular,immune responses triggered by RT,known as radio-immunotherapy,can partially inhibit the growth of distantly spreading tumors and recurrent tumors.How-ever,the safety and efficacy of radio-immunotherapy is impeded by the radio-resistance and poor immu-nogenicity of tumor.Herein,we report oxaliplatin(IV)-iron bimetallic nanoparticles(OXA/Fe NPs)as cascade sensitizing amplifiers for low-dose and robust radio-immunotherapy.The OXA/Fe NPs exhibit tumor-specific accumulation and activation of OXA(I)and Fe^(2+)in response to the reductive and acidic microenvironment within tumor cells.The cascade reactions of the released metallic drugs can sensitize RT by inducing DNA damage,increasing ROS and O_(2) levels,and amplifying the immunogenic cell death(ICD)effect after RT to facilitate potent immune activation.As a result,OXA/Fe NPs-based low-dose RT triggered a robust immune response and inhibited the distant and metastatic tumors effectively by a strong abscopal effect.Moreover,a long-term immunological memory effect to protect mice from tumor rechal-lenging is observed.Overall,the bimetallic NPs-based cascade sensitizing amplifier system offers an effi-cient radio-immunotherapy regimen that addresses the key challenges.展开更多
A series of 2 benzyl 1,3 dicabonyl derivatives was synthesized. Their insulin sensitizing activity was evaluated in 3T3 L1 preadipocyte cells. Compounds 3, 26 and 27 were found to possess strong insulin sens...A series of 2 benzyl 1,3 dicabonyl derivatives was synthesized. Their insulin sensitizing activity was evaluated in 3T3 L1 preadipocyte cells. Compounds 3, 26 and 27 were found to possess strong insulin sensitizing activity in vitro and were selected for further hypoglycemic evaluation in vivo.展开更多
Density functional theory(DFT)calculations were employed to investigate the adsorption behavior of NH_(3),AsH_(3),PH_(3),CO_(2),and CH_(4)molecules on both pristine and mono-vacancy phosphorene sheets.The pristine pho...Density functional theory(DFT)calculations were employed to investigate the adsorption behavior of NH_(3),AsH_(3),PH_(3),CO_(2),and CH_(4)molecules on both pristine and mono-vacancy phosphorene sheets.The pristine phosphorene surface showsweak physisorption with all the gasmolecules,inducing onlyminor changes in its structural and electronic properties.However,the introduction ofmono-vacancies significantly enhances the interaction strength with NH_(3),PH_(3),CO_(2),and CH_(4).These variations are attributed to substantial charge redistribution and orbital hybridization in the presence of defects.The defective phosphorene sheet also exhibits enhanced adsorption energies,along with favorable sensitivity and recovery characteristics,highlighting its potential as a promising gas sensor for NH_(3),AsH_(3),PH_(3),CO_(2),and CH_(4)at ambient conditions.展开更多
Objectives:Loneliness among left-behind adolescents is the most frequently reported emotional problem because of parental neglect.The present study explored the relationship between maternal absence and adolescent lon...Objectives:Loneliness among left-behind adolescents is the most frequently reported emotional problem because of parental neglect.The present study explored the relationship between maternal absence and adolescent loneliness as well as its mechanisms.Methods:The study included 305 participants(Meanage=15.99±0.81,48.9%females)in southeast China,and constructed a chain mediation model to test the roles of rejection sensitivity and friendship quality.Parent absence types,rejection sensitivity,friendship quality,and adolescent loneliness were all assessed with questionnaires.Results:The results showed that adolescents with a mother absent(both-parent absent,mother-only absent)experienced higher levels of loneliness than those with a mother not absent(father-only absent,non-parent absent)(β=0.3137,95%CI[0.0849,0.5425],p<0.01).Besides,the mediating roles of rejection sensitivity(β=0.0344,95%CI[0.0020,0.0808])and friendship quality(β=0.1198,95%CI[0.0049,0.2428])and their chain mediating role were found significant between maternal absence and loneliness(β=0.0245,95%CI[0.0015,0.0575]).Conclusions:These findings have revealed the significant impact of maternal absence on adolescent loneliness and provide important practical implications for educators to reduce adolescent loneliness.展开更多
In this study,the multi-scale(meso and macro)modelling was used to predict the electric response of the material.Porosity was introduced through a sugar-templating process to enhance compressibility and sensitivity.Me...In this study,the multi-scale(meso and macro)modelling was used to predict the electric response of the material.Porosity was introduced through a sugar-templating process to enhance compressibility and sensitivity.Mean-field homogenization was employed to predict the electrical conductivity of the nanocomposites,which was validated experimentally through I–V characterisation,confirming stable Ohmic behavior.The homogenised material parameters were incorporated into COMSOLMultiphysics to simulate diaphragmdeflection and capacitance variation under applied pressure.Experimental results showed a linear and stable capacitance response at the force magnitude of 0–7 N.The Graphene nanoplatelets(GnP)–Polydimethylsiloxane(PDMS)sensor demonstrated superior sensitivity(0.0032 pF/N)compared to the CNT–PDMS sensor(0.0019 pF/N),attributed to improved filler dispersion and higher effective surface area of GnP.Finite element simulations were further conducted to evaluate stress distribution in a GnP–PDMS-based capacitive sensor integrated into a shoe insole for gait analysis.The results correlated well with experimental capacitance changes,validating the sensor’s mechanical reliability and pressure sensitivity.This comparative study establishes the GnP–PDMS composite as a more effective candidate for low-cost,biocompatible,and high-performance flexible pressure sensors in wearable biomedical and gait monitoring applications.展开更多
To improve the theoretical prediction accuracy of static mechanical quantities in MEMS cantilever beams for microwave power detection chips,a distributed static model is proposed based on the deflection equation.An an...To improve the theoretical prediction accuracy of static mechanical quantities in MEMS cantilever beams for microwave power detection chips,a distributed static model is proposed based on the deflection equation.An analytical frame-work is established through the precise characterization of cantilever beam bending.The framework can accurately extract key electromechanical parameters,and the correlation between these parameters and geometric changes is systematically studied.Results show that the pull-in voltage increases with the gap but decreases with the length.The predicted pull-in voltage indi-cates a relative error of only 6.5%between the distributed static model and the simulation,which is significantly lower than that of the other two models.The overload power and sensitivity are also analyzed to facilitate performance trade-offs in chip design.The measured return loss varies between-66.46 and-10.56 dB over the 8-12 GHz frequency band,exhibiting a charac-teristic V-shaped trend.Moreover,the measured sensitivity of 66.5 fF/W closely matches the theoretical value of 69.3 fF/W,show-ing a relative error of 5.6%.These findings confirm that the distributed model outperforms the other two in terms of both accu-racy and physical realism,thereby providing important reference for the design of microwave power detection chips.展开更多
Invasive pests and pathogens cause immense damage globally,costing an estimated US$248 billion to the agricultural industry alone.Vehicles,such as farming and timber harvesting machinery and transportation trucks,can ...Invasive pests and pathogens cause immense damage globally,costing an estimated US$248 billion to the agricultural industry alone.Vehicles,such as farming and timber harvesting machinery and transportation trucks,can facilitate the rapid spread of biological invaders over distances far greater and more quickly than their natural dispersal ability.Understanding how frequent trips by these vehicles increase the spread of invasive agricultural and forestry pests can help inform effective biosecurity procedures before,during,or after an incursion.We used a case study of timber transport trucks in Aotearoa New Zealand to examine whether and how vehicles facilitate the spread of soil-borne pathogens between commercial forest plantations.Our results show that long-distance dispersal associated with truck movement facilitated the introduction of oomycete-like pathogens in 97% of forest sites within only one year,with pathogen loads within infected sites predicted at 84%of the sites’carrying capacity.Implementing preventative management strategies to reduce the transportation of infected soil by logging trucks,however,can reduce the spread by up to 50% after one year and reduce the pathogen load within infested sites by more than three times.Mitigating other human-assisted dispersal pathways can also help reduce spread.Reducing movement of forest visitors not involved in forestry activities,for instance,by closing forest sites to the public,can help to further reduce spread in addition to management related to harvesting activities.These results highlight the benefits of preventative management strategies in reducing the spread rate of novel soil pathogens through a high-intensity commercial forestry network but show that pest spread is still likely even with significant investment.展开更多
This study addresses the challenges confronting the ideological and political construction of general artificial intelligence curriculum-namely,the dilution of value guidance amid pluralistic intellectual currents,the...This study addresses the challenges confronting the ideological and political construction of general artificial intelligence curriculum-namely,the dilution of value guidance amid pluralistic intellectual currents,the superficial internalization of concepts resulting from didactic pedagogy,and the ineffectiveness of character cultivation stemming from fragmented and decontextualized techno-ethical cases.This paper proposes centering the value proposition on“Serving the Nation through Science and Technology”.Leveraging the deeply integrated industry-academia-research-application synergy,we integrate ideological and political elements into the comprehensive technological practice workflow.To achieve this,we(1)incorporate authentic enterprise project practicums to foster students’sense of responsibility;(2)construct a virtual debate platform on technology ethics dilemmas to develop ethical discernment;and(3)organize solution competitions targeting urgent social problems to incubate technology-for-good initiatives.Collectively,these approaches enhance students’technological mission awareness,ethical sensitivity,and social responsibility.展开更多
Maintaining the structural integrity of parallel natural gas pipelines during leakage-induced jet fires remains a critical engineering challenge.Existing methods often fail to account for the complex interactions amon...Maintaining the structural integrity of parallel natural gas pipelines during leakage-induced jet fires remains a critical engineering challenge.Existing methods often fail to account for the complex interactions among heat transfer,material behavior,and pipeline geometry,which can lead to overly simplified and potentially unsafe assessments.To address these limitations,this study develops a multiphysics approach that integrates small-orifice leakage theory with detailed thermo-fluid-structural simulations.The proposed framework contributes to a more accurate failure analysis through three main components:(1)coupled modeling that tracks transient heat flow and stress development as fire conditions evolve;(2)risk assessment incorporating spatial layout,material property changes with temperature,and operational limits;and(3)sensitivity analysis to identify key design factors that influence structural performance under high thermal loads.Simulation results demonstrate that thermal radiation from neighboring jet fires significantly accelerates material degradation,with inter-pipeline spacing emerging as a critical determinant of structural response.Notably,increasing the spacing between pipelines reduces thermal interaction and mechanical stress transfer.As a result,systems with optimized spacing exhibit markedly lower deformation than conventional configurations.These findings provide a foundation for re-evaluating pipeline layout strategies and strengthening safety protocols,particularly in high-risk environments where fire exposure can severely compromise structural reliability.The proposed approach offers actionable guidance for engineers and policymakers seeking to enhance the resilience of pipeline infrastructure under extreme thermal conditions.展开更多
Thermal spalling in heterogeneous rocks under rapid heating poses critical risks to deep mining and geothermal operations.In this study,we develop a coupled thermal-mechanical-damage(TM D)model that explicitly incorpo...Thermal spalling in heterogeneous rocks under rapid heating poses critical risks to deep mining and geothermal operations.In this study,we develop a coupled thermal-mechanical-damage(TM D)model that explicitly incorporates Weibull distributed heterogeneity to a single fracture in rock,and validate it against ceramic quenching and granite acoustic emission experiments.Distance based generalized sensitivity analysis(DGSA)is applied to quantify the influence and interactions of key parameters,revealing the dominant controls on spalling onset,severity,and damage morphology.The results demonstrate that thermal stress dominates crack initiation and propagation,that lateral constraints can significantly delay and suppress spalling,and that material heterogeneity markedly influences peak stress and damage modes within a certain range of thermal expansion coefficient and has multiple effects on thermal spalling.This study provides a theoretical basis for quantitative assessment and parameter optimization of thermal spalling processes in rock masses.展开更多
The Toraja Highlands,encompassing Tana Toraja and North Toraja,form the strategic upper reaches of the Saddang Watershed in South Sulawesi,where steep terrain,active land-cover change,and high ecological sensitivity c...The Toraja Highlands,encompassing Tana Toraja and North Toraja,form the strategic upper reaches of the Saddang Watershed in South Sulawesi,where steep terrain,active land-cover change,and high ecological sensitivity converge.This study addresses the need for an objective and validated ecological sensitivity map to support sustainable mountain watershed management.We construct an ecological sensitivity index based on principal component analysis using four key indicators:land cover,vegetation density(NDVI),slope,and rainfall,and evaluate its reliability through multi-source validation.Inputs integrate national elevation models,Landsat 8 imagery,and satellite-derived rainfall.Rainfall represents a multi-year climatology for 2015–2024,whereas land cover and NDVI reflect recent surface conditions derived from a cloud-free 2024 composite.The resulting sensitivity zonation indicates that 41.10%of Tana Toraja and 67.11%of North Toraja fall into the very high sensitivity class,concentrated on steep slopes and intensively converted landscapes.Eventbased spatial cross-validation against independent landslide records yields overall accuracies of 67.65%and 66.67%,while field verification produces Kappa values of 0.847 and 0.871.Stakeholder appraisal further corroborates the mapped patterns.Together,these convergent lines of evidence identify priority areas for reforestation,soil conservation,slope stabilization,and sustainable watershed management.The transparent and reproducible workflow supports evidence-based risk reduction and resilience building in the upper reaches of the Saddang Watershed.展开更多
Traditional oilfields face increasing extraction challenges, primarily due to reservoir quality degradation and production decline, which are further exacerbated by volatile international crude oil prices—illustrated...Traditional oilfields face increasing extraction challenges, primarily due to reservoir quality degradation and production decline, which are further exacerbated by volatile international crude oil prices—illustrated by Brent Crude’s trajectory from pandemic-induced negative pricing to geopolitically driven surges exceeding USD 100 per barrel. This study addresses these complexities through an integrated methodological framework applied to medium-permeability sandstone reservoirs in the Xinjiang oilfield by combining advanced numerical simulations with multivariate regression analysis. The methodology employs Latin Hypercube Sampling (LHS) to stratify geological parameter distributions and constructs heterogeneous reservoir models using Petrel software, rigorously validated through historical production data matching. Production forecasting integrates numerical simulation and Decline Curve Analysis (DCA), while investment estimation utilizes Ordinary Least Squares (OLS) regression to correlate engineering parameters with drilling and completion costs. Economic evaluation incorporates Discounted Cash Flow (DCF) modeling and breakeven analysis, establishing techno-economic boundaries via oil price sensitivity analysis ranging from USD 40 to 90 per barrel. Visualization tools, including 3D heatmaps, delineate nonlinear interactions among engineering, geological, and investment datasets under economic constraints. Key findings demonstrate that for the target reservoirs, as oil prices increase from USD 40 to USD 90 per barrel, the minimum economic thickness threshold decreases from approximately 5.7 m to about 2.5 m, with model prediction errors consistently below 25% across validation datasets. This framework provides scientifically grounded decision support for optimizing capital allocation and offers actionable insights to enhance undeveloped hydrocarbon development planning amid market uncertainty. Ultimately, it supports national energy security through technically robust and economically viable resource exploitation strategies.展开更多
Ground penetrating radar(GPR)offers a rapid and non-destructive approach to evaluating asphalt mixtures by capturing variations in their dielectric constant.As a critical electromagnetic parameter,the dielectric const...Ground penetrating radar(GPR)offers a rapid and non-destructive approach to evaluating asphalt mixtures by capturing variations in their dielectric constant.As a critical electromagnetic parameter,the dielectric constant demonstrates significant potential for assessing the material composition and mechanical properties of asphalt mixtures.However,the relationship between the dielectric constant and mechanical properties remains unclear.To investigate the factors affecting the dielectric constant and its correlation with the mechanical properties of asphalt mixtures,a systematic analysis of the influencing parameters was conducted.Fitting equations were established to quantify the relationships between the dielectric constant and mechanical properties.Firstly,the effects of compaction state,testing frequency,and testing temperature on the dielectric constant were evaluated.Subsequently,forward simulations of GPR were executed on asphalt pavements with diverse air voids and detection frequencies.Finally,a fitting analysis was performed to determine the correlation between the dielectric constant and the dynamic modulus,compressive strength,and splitting tensile strength.The results indicated that the dielectric constant increased with the compaction state,decreased with increasing testing frequency until stabilized,and was insignificantly affected by changes in testing temperature.The change of air void in asphalt pavement has significantly affected the amplitude and timing of electromagnetic wave reflection.A linear positive correlation was identified between the dielectric constant and dynamic modulus as well as compressive strength,while a quadratic positive correlation existed with splitting tensile strength.This study provided theoretical and practical foundations for enhancing the reliability and accuracy of non-destructive testing in asphalt pavement.展开更多
Objective:Long non-coding RNAs have been found to play a pivotal role in breast cancer,yet the majority of these lncRNAs remain to be thoroughly investigated.This study aimed to explore the role of differentially expr...Objective:Long non-coding RNAs have been found to play a pivotal role in breast cancer,yet the majority of these lncRNAs remain to be thoroughly investigated.This study aimed to explore the role of differentially expressed long non-coding RNAs(lncRNAs)in breast cancer stemness and drug sensitivity.Methods:Database mining was performed to evaluate the expression of LINC00467 in different types of breast cancer and its association with clinical features.The function of LINC00467 was examined through colony formation assays,quantitative reverse transcription PCR(qRT-PCR),and western blotting following LINC00467 silencing in breast cancer cell lines.Results:LINC00467 was significantly upregulated in various breast cancer subtypes with spatial specificity.Silencing LINC00467 reduced clonogenic capacity and downregulated the stemness-associated factor LIN28B as well as phosphorylated RAC-alpha serine/threonine-protein kinase(p-AKT).The transcription factors specificity protein 1(SP1)and E2F transcription factor 1(E2F1)were predicted to bind to the LINC00467 promoter.Furthermore,breast cancer samples with high LINC00467 expression displayed reduced sensitivity to AKT inhibitors,and high LINC00467 expression was negatively correlated with the therapeutic response to programmed cell death 1(PD-1)antibodies.Conclusion:Our findings suggest that spatially expressed LINC00467 may promote breast cancer stemness by regulating AKT signaling and could serve as a potential new therapeutic target and indicator of drug sensitivity in breast cancer.展开更多
基金supported by the National Natural Science Foundation of China(Nos.82273845,82304331,and 82360695)Guangxi Natural Science Foundation project(No.2023GXNSFBA026305).
文摘Hyperactivation of DNA repairing pathway is highly associated with the chemosensitivity and chemoresistance of cancer cells.In this manuscript,guided by cascaded one strain many compounds-global natural products social molecular networking(OSMAC-GNPS)strategy,a pair of epimeric environmental-induced metabolites were isolated from Aspergillus sp.EGF 15-0-3.Structurally,sterpiperazines A(1)and B(2)represent the first steroid-based indole alkaloids with unprecedented backbones.Biologically,compound 1 could be identified as a novel tyrosyl-DNA phosphodiesterase 1(Tdp1)inhibitor with a unique mechanism distinct from the reported modulators,and was able to significantly enhance the sensitivity of NCI-H460 cells to the clinic chemotherapeutic drug through inhibiting the DNA repairment and enhanced the DNA damage of cancer cells.
文摘In the presence of mixed micelle of a cationic and a nonionic surfactants,the reaction of scandium(Ⅲ) with phenylfluorone or its derivatives results in a very sensitive colouration:furthermore this chromophoric system tolerates the existence of a considerable amount of masking agents,so that many interfering ions can be masked and its selectivity would be further improved.After studying the optimum conditions and main charac- ters of some similar systems,the system of Sc(Ⅲ)—Orthonitrophenyuorone—Cetyltrimethylammonium Bromide(CTMAB)—Triton X-200 is chosen for the spectrophotometric determination of microamount of scandium.The proposed method shows not only high sensitivity(with a molar absorptivity of 2.12×1~sL mol^(-1)·cm^(-1))and selectivity,but also high tolerance of chromophoric conditions.Beer's law is obeyed over a range of 0～6.0 μg Sc/25ml.If the dual-wavelength method is applied,a much higher molar absorptivity o|' 3.04×10~5L·mol^(-1)·cm^(-1)than those of other systems ever reported in the literatures can be attained:more- over.its linear range is extended to 0～8.0 μg Sc/25ml and its reproducibility is also improved.
基金Project supported by the Guiding Project of Science and Technology Department of Fujian Province(2019N0016)Key Project of Advanced Industry of Science and Technology Department of Fujian Province(2017Y0067)+1 种基金the Foundation of Education Department of Fujian Province(JT180293)Natural Science Foundation of Zhangzhou Science&Technology Bureau(2017G02010028)。
文摘The long persistent phosphors of Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)with Nd^(3+)as sensitized ions and Tb^(3+)as emission centers were synthesized using high temperature solid state reaction.The crystal structure and defects,excitation and emission spectra,decay curves and thermoluminescence(TL) curves of the phosphors were investigated.The synthesized Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)is essentially in line with the standard card PDF#49-1079.The emission band with main peak at 548 nm exhibits the characteristic transitions of ^(5)D_(3)-^(7)F_(j)(j=5,4) and ^(5)D_(3)-^(7)F_(j)(j=6,5,4,3) of Tb^(3+).The analysis of excitation and emission spectra shows that there exists the overlap between the emission peaks of Nd^(3+)at 466 and 485 nm and the excitation of Tb^(3+)at 443 and 485 nm,and the energy transfer from Nd^(3+)to Tb^(3+)plays an important role in the improvement of luminescence properties.The decay curves shows that Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)has longer afterglow time than ZrP_(2)O_(7) and Zr_(0.982)P_(2)O_(7):0.018 Tb^(3+).Additionally,the TL curves indicate that the trap depth at 0.72 eV in Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)is to the benefit of the afterglow time.The possible luminescence mechanism of ZrP_(2)O_(7):Tb^(3+),Nd^(3+)is proposed on the basis of the XPS spectra,EPR spectra,excitation and emission spectra,decay curves,TL curves and the analysis of defect equations.
基金supported by JSPS KAKENHI Grant Number 19H04475,21H03830,22K19926 and 24K03289.
文摘Combining hyperthermia and chemotherapy for maximum anticancer efficacy remains a challenge because drugtolerant cancer cells often evade this synergistic treatment due to drug resistance and asynchronous drug release.In this study,multifunctional scaffolds were designed to efficiently treat drug-tolerant breast cancer by improving the sensitization of breast cancer cells and synchronizing anticancer drug release with magnetic hyperthermia.The scaffolds contained microRNA-encapsulated matrix metalloproteinase-cleavable liposomes,doxorubicin-encapsulated thermoresponsive liposomes and Fe_(3)O_(4)nanoparticles.The scaffolds could release microRNA specifically to improve the sensitization of breast cancer cells to anticancer drugs.The scaffolds also showed excellent hyperthermia effects under alternating magnetic field irradiation.Moreover,doxorubicin release was synchronized with magnetic hyperthermia.In vitro and in vivo studies demonstrated that the scaffolds effectively reduced drug resistance and eliminated doxorubicin-tolerant MDA-MB-231 cells through the syner-gistic effect of magnetic hyperthermia and sensitizing chemotherapy.Additionally,the scaffolds could support the proliferation and adipogenic differentiation of stem cells for adipose tissue regeneration after killing cancer cells at a late therapeutic stage.These composite scaffolds offer an innovative strategy for treating breast cancer,with synergistic anticancer effects and regenerative functions.
基金This work is supported by grants from the National Natural Science Foundation of China(Nos.22275081,and 82372117)Guangdong Basic and Applied Basic Research Foundation(2021B1515120065,China)+2 种基金Guangzhou Science and Technology Bureau(202206010068)the Natural Science Foundation of Hebei Province(E2023205004,China)China Postdoctoral Science Foundation(2022M711532 and 2022T150302).
文摘Radiotherapy(RT)is one of the most feasible and routinely used therapeutic modalities for treating malignant tumors.In particular,immune responses triggered by RT,known as radio-immunotherapy,can partially inhibit the growth of distantly spreading tumors and recurrent tumors.How-ever,the safety and efficacy of radio-immunotherapy is impeded by the radio-resistance and poor immu-nogenicity of tumor.Herein,we report oxaliplatin(IV)-iron bimetallic nanoparticles(OXA/Fe NPs)as cascade sensitizing amplifiers for low-dose and robust radio-immunotherapy.The OXA/Fe NPs exhibit tumor-specific accumulation and activation of OXA(I)and Fe^(2+)in response to the reductive and acidic microenvironment within tumor cells.The cascade reactions of the released metallic drugs can sensitize RT by inducing DNA damage,increasing ROS and O_(2) levels,and amplifying the immunogenic cell death(ICD)effect after RT to facilitate potent immune activation.As a result,OXA/Fe NPs-based low-dose RT triggered a robust immune response and inhibited the distant and metastatic tumors effectively by a strong abscopal effect.Moreover,a long-term immunological memory effect to protect mice from tumor rechal-lenging is observed.Overall,the bimetallic NPs-based cascade sensitizing amplifier system offers an effi-cient radio-immunotherapy regimen that addresses the key challenges.
文摘A series of 2 benzyl 1,3 dicabonyl derivatives was synthesized. Their insulin sensitizing activity was evaluated in 3T3 L1 preadipocyte cells. Compounds 3, 26 and 27 were found to possess strong insulin sensitizing activity in vitro and were selected for further hypoglycemic evaluation in vivo.
基金financial support to conduct this research from the Science and Engineering Research Board(SERB)through a state university research excellence(SURE)grant(SUR/2022/004935).
文摘Density functional theory(DFT)calculations were employed to investigate the adsorption behavior of NH_(3),AsH_(3),PH_(3),CO_(2),and CH_(4)molecules on both pristine and mono-vacancy phosphorene sheets.The pristine phosphorene surface showsweak physisorption with all the gasmolecules,inducing onlyminor changes in its structural and electronic properties.However,the introduction ofmono-vacancies significantly enhances the interaction strength with NH_(3),PH_(3),CO_(2),and CH_(4).These variations are attributed to substantial charge redistribution and orbital hybridization in the presence of defects.The defective phosphorene sheet also exhibits enhanced adsorption energies,along with favorable sensitivity and recovery characteristics,highlighting its potential as a promising gas sensor for NH_(3),AsH_(3),PH_(3),CO_(2),and CH_(4)at ambient conditions.
基金supported by the National Natural Science Foundation of China(32171069).
文摘Objectives:Loneliness among left-behind adolescents is the most frequently reported emotional problem because of parental neglect.The present study explored the relationship between maternal absence and adolescent loneliness as well as its mechanisms.Methods:The study included 305 participants(Meanage=15.99±0.81,48.9%females)in southeast China,and constructed a chain mediation model to test the roles of rejection sensitivity and friendship quality.Parent absence types,rejection sensitivity,friendship quality,and adolescent loneliness were all assessed with questionnaires.Results:The results showed that adolescents with a mother absent(both-parent absent,mother-only absent)experienced higher levels of loneliness than those with a mother not absent(father-only absent,non-parent absent)(β=0.3137,95%CI[0.0849,0.5425],p<0.01).Besides,the mediating roles of rejection sensitivity(β=0.0344,95%CI[0.0020,0.0808])and friendship quality(β=0.1198,95%CI[0.0049,0.2428])and their chain mediating role were found significant between maternal absence and loneliness(β=0.0245,95%CI[0.0015,0.0575]).Conclusions:These findings have revealed the significant impact of maternal absence on adolescent loneliness and provide important practical implications for educators to reduce adolescent loneliness.
文摘In this study,the multi-scale(meso and macro)modelling was used to predict the electric response of the material.Porosity was introduced through a sugar-templating process to enhance compressibility and sensitivity.Mean-field homogenization was employed to predict the electrical conductivity of the nanocomposites,which was validated experimentally through I–V characterisation,confirming stable Ohmic behavior.The homogenised material parameters were incorporated into COMSOLMultiphysics to simulate diaphragmdeflection and capacitance variation under applied pressure.Experimental results showed a linear and stable capacitance response at the force magnitude of 0–7 N.The Graphene nanoplatelets(GnP)–Polydimethylsiloxane(PDMS)sensor demonstrated superior sensitivity(0.0032 pF/N)compared to the CNT–PDMS sensor(0.0019 pF/N),attributed to improved filler dispersion and higher effective surface area of GnP.Finite element simulations were further conducted to evaluate stress distribution in a GnP–PDMS-based capacitive sensor integrated into a shoe insole for gait analysis.The results correlated well with experimental capacitance changes,validating the sensor’s mechanical reliability and pressure sensitivity.This comparative study establishes the GnP–PDMS composite as a more effective candidate for low-cost,biocompatible,and high-performance flexible pressure sensors in wearable biomedical and gait monitoring applications.
基金supported by the National Natural Science Foundation of China(61904089)the Province Natural Science Foundation of Jiangsu(BK20190731).
文摘To improve the theoretical prediction accuracy of static mechanical quantities in MEMS cantilever beams for microwave power detection chips,a distributed static model is proposed based on the deflection equation.An analytical frame-work is established through the precise characterization of cantilever beam bending.The framework can accurately extract key electromechanical parameters,and the correlation between these parameters and geometric changes is systematically studied.Results show that the pull-in voltage increases with the gap but decreases with the length.The predicted pull-in voltage indi-cates a relative error of only 6.5%between the distributed static model and the simulation,which is significantly lower than that of the other two models.The overload power and sensitivity are also analyzed to facilitate performance trade-offs in chip design.The measured return loss varies between-66.46 and-10.56 dB over the 8-12 GHz frequency band,exhibiting a charac-teristic V-shaped trend.Moreover,the measured sensitivity of 66.5 fF/W closely matches the theoretical value of 69.3 fF/W,show-ing a relative error of 5.6%.These findings confirm that the distributed model outperforms the other two in terms of both accu-racy and physical realism,thereby providing important reference for the design of microwave power detection chips.
基金supported by the Forest Growers Levy Trust(QT-10353)the Ministry for Primary Industries and the Sustainable Food and Fibre Futures fund(SFFF22023)the Strategic Science Investment Fund(CO4X1703)for funding this research.
文摘Invasive pests and pathogens cause immense damage globally,costing an estimated US$248 billion to the agricultural industry alone.Vehicles,such as farming and timber harvesting machinery and transportation trucks,can facilitate the rapid spread of biological invaders over distances far greater and more quickly than their natural dispersal ability.Understanding how frequent trips by these vehicles increase the spread of invasive agricultural and forestry pests can help inform effective biosecurity procedures before,during,or after an incursion.We used a case study of timber transport trucks in Aotearoa New Zealand to examine whether and how vehicles facilitate the spread of soil-borne pathogens between commercial forest plantations.Our results show that long-distance dispersal associated with truck movement facilitated the introduction of oomycete-like pathogens in 97% of forest sites within only one year,with pathogen loads within infected sites predicted at 84%of the sites’carrying capacity.Implementing preventative management strategies to reduce the transportation of infected soil by logging trucks,however,can reduce the spread by up to 50% after one year and reduce the pathogen load within infested sites by more than three times.Mitigating other human-assisted dispersal pathways can also help reduce spread.Reducing movement of forest visitors not involved in forestry activities,for instance,by closing forest sites to the public,can help to further reduce spread in addition to management related to harvesting activities.These results highlight the benefits of preventative management strategies in reducing the spread rate of novel soil pathogens through a high-intensity commercial forestry network but show that pest spread is still likely even with significant investment.
基金supported by 2024 General Program from the Beijing Association of Higher Education(MS2024232).
文摘This study addresses the challenges confronting the ideological and political construction of general artificial intelligence curriculum-namely,the dilution of value guidance amid pluralistic intellectual currents,the superficial internalization of concepts resulting from didactic pedagogy,and the ineffectiveness of character cultivation stemming from fragmented and decontextualized techno-ethical cases.This paper proposes centering the value proposition on“Serving the Nation through Science and Technology”.Leveraging the deeply integrated industry-academia-research-application synergy,we integrate ideological and political elements into the comprehensive technological practice workflow.To achieve this,we(1)incorporate authentic enterprise project practicums to foster students’sense of responsibility;(2)construct a virtual debate platform on technology ethics dilemmas to develop ethical discernment;and(3)organize solution competitions targeting urgent social problems to incubate technology-for-good initiatives.Collectively,these approaches enhance students’technological mission awareness,ethical sensitivity,and social responsibility.
文摘Maintaining the structural integrity of parallel natural gas pipelines during leakage-induced jet fires remains a critical engineering challenge.Existing methods often fail to account for the complex interactions among heat transfer,material behavior,and pipeline geometry,which can lead to overly simplified and potentially unsafe assessments.To address these limitations,this study develops a multiphysics approach that integrates small-orifice leakage theory with detailed thermo-fluid-structural simulations.The proposed framework contributes to a more accurate failure analysis through three main components:(1)coupled modeling that tracks transient heat flow and stress development as fire conditions evolve;(2)risk assessment incorporating spatial layout,material property changes with temperature,and operational limits;and(3)sensitivity analysis to identify key design factors that influence structural performance under high thermal loads.Simulation results demonstrate that thermal radiation from neighboring jet fires significantly accelerates material degradation,with inter-pipeline spacing emerging as a critical determinant of structural response.Notably,increasing the spacing between pipelines reduces thermal interaction and mechanical stress transfer.As a result,systems with optimized spacing exhibit markedly lower deformation than conventional configurations.These findings provide a foundation for re-evaluating pipeline layout strategies and strengthening safety protocols,particularly in high-risk environments where fire exposure can severely compromise structural reliability.The proposed approach offers actionable guidance for engineers and policymakers seeking to enhance the resilience of pipeline infrastructure under extreme thermal conditions.
基金funded by the National Natural Science Foundation of China(Nos.52574100,52574001,and 52311530070)the Major National Science and Technology Project for Deep Earth of China(No.2024ZD1003805)+1 种基金the Fundamental Research Funds for the Central Universities of China(No.FRF-IDRY-20-003,Interdisciplinary Research Project for Young Teachers of USTB)DE gratefully acknowledges support from the G.Albert Shoemaker endowment.
文摘Thermal spalling in heterogeneous rocks under rapid heating poses critical risks to deep mining and geothermal operations.In this study,we develop a coupled thermal-mechanical-damage(TM D)model that explicitly incorporates Weibull distributed heterogeneity to a single fracture in rock,and validate it against ceramic quenching and granite acoustic emission experiments.Distance based generalized sensitivity analysis(DGSA)is applied to quantify the influence and interactions of key parameters,revealing the dominant controls on spalling onset,severity,and damage morphology.The results demonstrate that thermal stress dominates crack initiation and propagation,that lateral constraints can significantly delay and suppress spalling,and that material heterogeneity markedly influences peak stress and damage modes within a certain range of thermal expansion coefficient and has multiple effects on thermal spalling.This study provides a theoretical basis for quantitative assessment and parameter optimization of thermal spalling processes in rock masses.
基金funded by the Ministry of Higher Education,Science and Technology,Republic of Indonesia through the Indonesia Collaborative Research(Riset Kolaborasi Indonesia)grant(Number:01319/UN4.22/PT.01.03/2025)。
文摘The Toraja Highlands,encompassing Tana Toraja and North Toraja,form the strategic upper reaches of the Saddang Watershed in South Sulawesi,where steep terrain,active land-cover change,and high ecological sensitivity converge.This study addresses the need for an objective and validated ecological sensitivity map to support sustainable mountain watershed management.We construct an ecological sensitivity index based on principal component analysis using four key indicators:land cover,vegetation density(NDVI),slope,and rainfall,and evaluate its reliability through multi-source validation.Inputs integrate national elevation models,Landsat 8 imagery,and satellite-derived rainfall.Rainfall represents a multi-year climatology for 2015–2024,whereas land cover and NDVI reflect recent surface conditions derived from a cloud-free 2024 composite.The resulting sensitivity zonation indicates that 41.10%of Tana Toraja and 67.11%of North Toraja fall into the very high sensitivity class,concentrated on steep slopes and intensively converted landscapes.Eventbased spatial cross-validation against independent landslide records yields overall accuracies of 67.65%and 66.67%,while field verification produces Kappa values of 0.847 and 0.871.Stakeholder appraisal further corroborates the mapped patterns.Together,these convergent lines of evidence identify priority areas for reforestation,soil conservation,slope stabilization,and sustainable watershed management.The transparent and reproducible workflow supports evidence-based risk reduction and resilience building in the upper reaches of the Saddang Watershed.
文摘Traditional oilfields face increasing extraction challenges, primarily due to reservoir quality degradation and production decline, which are further exacerbated by volatile international crude oil prices—illustrated by Brent Crude’s trajectory from pandemic-induced negative pricing to geopolitically driven surges exceeding USD 100 per barrel. This study addresses these complexities through an integrated methodological framework applied to medium-permeability sandstone reservoirs in the Xinjiang oilfield by combining advanced numerical simulations with multivariate regression analysis. The methodology employs Latin Hypercube Sampling (LHS) to stratify geological parameter distributions and constructs heterogeneous reservoir models using Petrel software, rigorously validated through historical production data matching. Production forecasting integrates numerical simulation and Decline Curve Analysis (DCA), while investment estimation utilizes Ordinary Least Squares (OLS) regression to correlate engineering parameters with drilling and completion costs. Economic evaluation incorporates Discounted Cash Flow (DCF) modeling and breakeven analysis, establishing techno-economic boundaries via oil price sensitivity analysis ranging from USD 40 to 90 per barrel. Visualization tools, including 3D heatmaps, delineate nonlinear interactions among engineering, geological, and investment datasets under economic constraints. Key findings demonstrate that for the target reservoirs, as oil prices increase from USD 40 to USD 90 per barrel, the minimum economic thickness threshold decreases from approximately 5.7 m to about 2.5 m, with model prediction errors consistently below 25% across validation datasets. This framework provides scientifically grounded decision support for optimizing capital allocation and offers actionable insights to enhance undeveloped hydrocarbon development planning amid market uncertainty. Ultimately, it supports national energy security through technically robust and economically viable resource exploitation strategies.
基金supported by the Major Program of Xiangjiang Laboratory(No.22XJ01009)National Natural Science Foundation of China(Grant Nos.52227815,52078065,and 52178414)the Postgraduate Scientific Research Innovation Project of Hunan Province(Nos.CX20230852 and CX20230848).
文摘Ground penetrating radar(GPR)offers a rapid and non-destructive approach to evaluating asphalt mixtures by capturing variations in their dielectric constant.As a critical electromagnetic parameter,the dielectric constant demonstrates significant potential for assessing the material composition and mechanical properties of asphalt mixtures.However,the relationship between the dielectric constant and mechanical properties remains unclear.To investigate the factors affecting the dielectric constant and its correlation with the mechanical properties of asphalt mixtures,a systematic analysis of the influencing parameters was conducted.Fitting equations were established to quantify the relationships between the dielectric constant and mechanical properties.Firstly,the effects of compaction state,testing frequency,and testing temperature on the dielectric constant were evaluated.Subsequently,forward simulations of GPR were executed on asphalt pavements with diverse air voids and detection frequencies.Finally,a fitting analysis was performed to determine the correlation between the dielectric constant and the dynamic modulus,compressive strength,and splitting tensile strength.The results indicated that the dielectric constant increased with the compaction state,decreased with increasing testing frequency until stabilized,and was insignificantly affected by changes in testing temperature.The change of air void in asphalt pavement has significantly affected the amplitude and timing of electromagnetic wave reflection.A linear positive correlation was identified between the dielectric constant and dynamic modulus as well as compressive strength,while a quadratic positive correlation existed with splitting tensile strength.This study provided theoretical and practical foundations for enhancing the reliability and accuracy of non-destructive testing in asphalt pavement.
基金supported by grants from the Natural Science Foundation of Hunan Province(2023JJ30879,2026JJ80914)。
文摘Objective:Long non-coding RNAs have been found to play a pivotal role in breast cancer,yet the majority of these lncRNAs remain to be thoroughly investigated.This study aimed to explore the role of differentially expressed long non-coding RNAs(lncRNAs)in breast cancer stemness and drug sensitivity.Methods:Database mining was performed to evaluate the expression of LINC00467 in different types of breast cancer and its association with clinical features.The function of LINC00467 was examined through colony formation assays,quantitative reverse transcription PCR(qRT-PCR),and western blotting following LINC00467 silencing in breast cancer cell lines.Results:LINC00467 was significantly upregulated in various breast cancer subtypes with spatial specificity.Silencing LINC00467 reduced clonogenic capacity and downregulated the stemness-associated factor LIN28B as well as phosphorylated RAC-alpha serine/threonine-protein kinase(p-AKT).The transcription factors specificity protein 1(SP1)and E2F transcription factor 1(E2F1)were predicted to bind to the LINC00467 promoter.Furthermore,breast cancer samples with high LINC00467 expression displayed reduced sensitivity to AKT inhibitors,and high LINC00467 expression was negatively correlated with the therapeutic response to programmed cell death 1(PD-1)antibodies.Conclusion:Our findings suggest that spatially expressed LINC00467 may promote breast cancer stemness by regulating AKT signaling and could serve as a potential new therapeutic target and indicator of drug sensitivity in breast cancer.
