Laser Speckle Contrast Imaging(LSCI)plays an important role in studying blood flow,but suffers from limited penetration depth of light in turbid tissue.The strong scattering of tissue obviously reduces the image contr...Laser Speckle Contrast Imaging(LSCI)plays an important role in studying blood flow,but suffers from limited penetration depth of light in turbid tissue.The strong scattering of tissue obviously reduces the image contrast which decreases the sensitivity to flow velocity.Some image processing or optical clearing methods have been proposed to lessen the deficiency,but quantitative assessment of improvement is seldom given.In this study,LSCI was applied to monitor the blood flow through a capillary embedded within various tissue phantoms at depths of 0.25,0.45,0.65,0.85 and 1.05 mm,and the flow velocity in capillary was controllable from 0 to 4mm/s.Here,glycerol,a common optical clearing agent,was mixed with Intralipid at different volume ratio to make the reduced scattering coefficient of tissue phantom decrease from 13.00 to 0.50 cm−1.The quantitative analysis demonstrates that the optical clearing method can obviously enhance the image contrast,imaging depth,and sensitivity to blood flow velocity.Comparing the Laser Speckle Contrast Analysis methods and the optical clearing method,we find that for typical turbid tissue,the sensitivity to velocity estimated by the Laser Speckle Temporal Contrast Analysis(LSTCA)is twice of that by the Laser Speckle Spatial Contrast Analysis(LSSCA);while the sensitivity to velocity estimated by using the two analysis methods has a 10-fold increase,respectively,if addition of glycerol makes the reduced scattering coefficient of tissue phantom decrease by 30%.Combining the LSTCA and the optical clearing method,the sensitivity to flow velocity will be further enhanced.展开更多
The sensitivity of the D^0-D^-0 mixing parameters x and y is estimated in the wrong-sign decay D^0→K^＋π^-π^0 by time-dependent amplitude analysis. The resolution of the D^0 lifetime is essential in time-dependent ...The sensitivity of the D^0-D^-0 mixing parameters x and y is estimated in the wrong-sign decay D^0→K^＋π^-π^0 by time-dependent amplitude analysis. The resolution of the D^0 lifetime is essential in time-dependent Dalitz analyses. The Belle II detector, which aims to collect a total integrated luminosity of 50 ab^-1 of data, has σ = 140 fs in Monte Carlo studies, a factor of two improvement over that of Belle and Ba Bar, so the produced Dalitz signal Monte Carlo samples are smeared with this resolution. Then a time-dependent Dalitz plot fitting is performed on these smeared samples, and the sensitivity of D^0-D^-0 mixing parameters are σx = 0.057% and σy = 0.049%. These are about an order of magnitude improvement on current experimental results, without considering background effects.展开更多
Recently,Ahmed et al.(Commun Stat Theory Methods 47(2):324-343,2018)have introduced the idea of simultaneously estimating means of two sensitive variables by collecting one scrambled response and another pseudo-respon...Recently,Ahmed et al.(Commun Stat Theory Methods 47(2):324-343,2018)have introduced the idea of simultaneously estimating means of two sensitive variables by collecting one scrambled response and another pseudo-response.In this paper,we extend their idea to the simultaneous estimation of two means by making use of the forced quantitative randomized response model of Gjestvang and Singh(Metrika 66(2):243-257,2007)but then re-scrambling the scrambled scores.This idea of re-scrambling already scrambled responses seems completely new in the field of randomized response sampling.The performance of the proposed forced quantitative randomized response model has been investigated analytically as well as empirically.展开更多
基金supported by the National Natural Science Foundation(Grant Nos.30770552,60828009 and 30911120074)of China.
文摘Laser Speckle Contrast Imaging(LSCI)plays an important role in studying blood flow,but suffers from limited penetration depth of light in turbid tissue.The strong scattering of tissue obviously reduces the image contrast which decreases the sensitivity to flow velocity.Some image processing or optical clearing methods have been proposed to lessen the deficiency,but quantitative assessment of improvement is seldom given.In this study,LSCI was applied to monitor the blood flow through a capillary embedded within various tissue phantoms at depths of 0.25,0.45,0.65,0.85 and 1.05 mm,and the flow velocity in capillary was controllable from 0 to 4mm/s.Here,glycerol,a common optical clearing agent,was mixed with Intralipid at different volume ratio to make the reduced scattering coefficient of tissue phantom decrease from 13.00 to 0.50 cm−1.The quantitative analysis demonstrates that the optical clearing method can obviously enhance the image contrast,imaging depth,and sensitivity to blood flow velocity.Comparing the Laser Speckle Contrast Analysis methods and the optical clearing method,we find that for typical turbid tissue,the sensitivity to velocity estimated by the Laser Speckle Temporal Contrast Analysis(LSTCA)is twice of that by the Laser Speckle Spatial Contrast Analysis(LSSCA);while the sensitivity to velocity estimated by using the two analysis methods has a 10-fold increase,respectively,if addition of glycerol makes the reduced scattering coefficient of tissue phantom decrease by 30%.Combining the LSTCA and the optical clearing method,the sensitivity to flow velocity will be further enhanced.
基金Supported by National Natural Science Foundation of China(11475164,11475169,11675166)
文摘The sensitivity of the D^0-D^-0 mixing parameters x and y is estimated in the wrong-sign decay D^0→K^＋π^-π^0 by time-dependent amplitude analysis. The resolution of the D^0 lifetime is essential in time-dependent Dalitz analyses. The Belle II detector, which aims to collect a total integrated luminosity of 50 ab^-1 of data, has σ = 140 fs in Monte Carlo studies, a factor of two improvement over that of Belle and Ba Bar, so the produced Dalitz signal Monte Carlo samples are smeared with this resolution. Then a time-dependent Dalitz plot fitting is performed on these smeared samples, and the sensitivity of D^0-D^-0 mixing parameters are σx = 0.057% and σy = 0.049%. These are about an order of magnitude improvement on current experimental results, without considering background effects.
文摘Recently,Ahmed et al.(Commun Stat Theory Methods 47(2):324-343,2018)have introduced the idea of simultaneously estimating means of two sensitive variables by collecting one scrambled response and another pseudo-response.In this paper,we extend their idea to the simultaneous estimation of two means by making use of the forced quantitative randomized response model of Gjestvang and Singh(Metrika 66(2):243-257,2007)but then re-scrambling the scrambled scores.This idea of re-scrambling already scrambled responses seems completely new in the field of randomized response sampling.The performance of the proposed forced quantitative randomized response model has been investigated analytically as well as empirically.
