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骨疏康干预破骨细胞:激活核因子E2相关因子2调控c-Fos/NFATc1通路 被引量:3
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作者 侯成志 韩佳童 +4 位作者 魏光成 卓泽川 李秋月 赵勇 俞张镜泽 《中国组织工程研究》 CAS 北大核心 2025年第2期279-285,共7页
背景:已有研究表明,骨疏康通过调节核苷酸、氨基酸代谢和免疫机制影响骨骼代谢,目前骨疏康治疗骨质疏松症的机制研究主要聚焦于调控成骨细胞,对破骨细胞的关注较少。目的:以RAW 264.7细胞为实验对象,从破骨细胞角度探讨骨疏康治疗骨质... 背景:已有研究表明,骨疏康通过调节核苷酸、氨基酸代谢和免疫机制影响骨骼代谢,目前骨疏康治疗骨质疏松症的机制研究主要聚焦于调控成骨细胞,对破骨细胞的关注较少。目的:以RAW 264.7细胞为实验对象,从破骨细胞角度探讨骨疏康治疗骨质疏松症的机制。方法:取8周龄雌性SD大鼠24只,采用随机数字表法分为4组(n=6),3个实验组分别灌胃给予1,2,4 g/kg的骨疏康药液(2次/d),对照组灌胃给予等量蒸馏水(2次/d),连续灌胃7 d后抽取大鼠主动脉血,离心收集血清,同组血清合并,获得低、中、高浓度的骨疏康含药血清及正常血清,进行后续实验。①将RAW 264.7细胞分6组培养:对照组加入正常血清,低、中、高浓度组分别加入低、中、高浓度的骨疏康含药血清,Nrf2抑制剂组加入核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)抑制剂ML385,Nrf2激活剂组加入Nrf2激活剂t-BHQ,采用CCK8法检测细胞相对活性。②将第3代RAW 264.7细胞分5组培养:空白对照组加入正常血清,破骨组加入核因子κB受体活化因子配体(receptor activator of nuclear factorκB ligand,RANKL),低、中、高浓度组在加入RANKL的基础上分别加入低、中、高浓度的骨疏康含药血清,培养5 d后进行抗酒石酸酸性磷酸染色。③将RAW 264.7细胞分5组培养:空白对照组加入正常血清,破骨组加入正常血清与RANKL,高浓度+破骨组加入RANKL+高浓度骨疏康含药血清,破骨+Nrf2激动剂组加入RANKL+t-BHQ,高浓度+破骨+Nrf2抑制剂组加入RANKL+高浓度骨疏康含药血清+ML385,培养5 d后进行Western Blot与活性氧含量检测。结果与结论:①CCK8检测结果显示,骨疏康含药血清及Nrf2抑制剂、激动剂对RAW 264.7细胞活力无明显影响;②抗酒石酸酸性磷酸染色结果显示,骨疏康含药血清呈浓度依赖性抑制破骨细胞的分化;③Western Blot与活性氧含量检测结果显示,与空白对照组比较,破骨组Nrf2蛋白表达降低(P<0.05),c-Fos、NFATc1蛋白表达与活性氧含量升高(P<0.05);与破骨组比较,高浓度+破骨组、破骨+Nrf2激动剂组、高浓度+破骨+Nrf2抑制剂组Nrf2蛋白表达升高、活性氧含量降低(P<0.05),高浓度+破骨组、破骨+Nrf2激动剂组c-Fos、NFATc1蛋白表达降低(P<0.05);与高浓度+破骨组比较,高浓度+破骨+Nrf2抑制剂组Nrf2蛋白表达降低(P<0.05),活性氧含量升高(P<0.05);④结果表明,骨疏康通过激活Nrf2减少活性氧生成,进而抑制下游c-Fos/NFATc1通路表达和破骨细胞分化。 展开更多
关键词 骨质疏松症 骨疏康 含药血清 破骨细胞 Nrf2 c-fos/NFATc1通路 RAW 264.7细胞
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太灵丹含药血清调控FOS基因对高糖诱导足细胞损伤及PI3K/Akt/mTOR信号转导通路的影响
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作者 刘宇幸 李敏州 +6 位作者 杨一文 王权 俞璐 杨俊 陆晨妍 牛洋 邓斌 《环球中医药》 2025年第11期2256-2263,共8页
目的观察太灵丹含药血清调控FOS原癌基因(fos proto-oncogene,FOS)对高糖诱导的足细胞损伤及磷脂酰肌醇-3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(phosphatidylinositide 3-kinase/protein kinase B/mammalian target of rapamycin,PI3... 目的观察太灵丹含药血清调控FOS原癌基因(fos proto-oncogene,FOS)对高糖诱导的足细胞损伤及磷脂酰肌醇-3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(phosphatidylinositide 3-kinase/protein kinase B/mammalian target of rapamycin,PI3K/Akt/mTOR)通路的影响及分子机制。方法将小鼠肾脏足细胞MPC5分为正常血清组(NC组)、高糖+正常血清组(HG+NS组)、高糖+含药血清组(HG+DS组)、正常培养基+对照病毒感染组(sh-NC组)、高糖+对照病毒感染组(sh-NC+HG组)、高糖+敲减病毒感染组(sh-FOS+HG组)。采用细胞活力检测法(cell counting kit-8,CCK-8)检测足细胞活力,流式细胞检测足细胞的凋亡水平,逆转录实时定量PCR(quantitative reverse transcription-polymerase chain reaction,qRT-PCR)检测FOS mRNA表达水平,采用蛋白免疫印迹(Western blot,WB)检测FOS、足细胞肾病蛋白(nephrin)、足细胞裂隙膜蛋白(podocin)、半胱氨酸天冬氨酸蛋白水解酶-3(cysteinyl aspartate specific 3,Caspase-3)、半胱氨酸天冬氨酸蛋白水解酶-9(cysteinyl aspartate specific 9,Caspase-9)、PI3K、p-PI3K、Akt、p-Akt、mTOR、p-mTOR的蛋白表达水平。结果与NC组相比,HG+NS组足细胞增殖能力显著降低(P<0.01),细胞凋亡率显著升高(P<0.01),足细胞标志蛋白(podocin、nephrin)明显降低(P<0.05),足细胞凋亡蛋白(Caspase-3、Caspase-9)明显升高(P<0.05)。太灵丹含药血清干预后,明显提高足细胞增殖能力(P<0.05),降低细胞凋亡率(P<0.05),上调podocin、nephrin蛋白表达水平(P<0.05),下调Caspase-3、Caspase-9蛋白表达水平(P<0.05)。与sh-NC组相比,sh-NC+HG组增殖能力显著降低(P<0.01),凋亡率显著升高(P<0.01),Caspase-3、Caspase-9、PI3K、Akt、mTOR的蛋白表达升高(P<0.05),p-PI3K、p-Akt、p-mTOR的蛋白表达降低(P<0.05)。与sh-NC+HG组相比,sh-FOS+HG组上述表现更加明显,且差异显著(P<0.01或0.05)。经过FOS基因敲减后,FOS的基因及蛋白表达均明显降低(P<0.01),说明本实验目的基因敲减效率差异明显。结论太灵丹含药血清通过上调FOS基因表达,激活PI3K/Akt/mTOR通路,从而减轻高糖诱导的足细胞损伤。 展开更多
关键词 太灵丹 含药血清 足细胞损伤 fos原癌基因 磷脂酰肌醇-3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号转导通路
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雪松醇调节miR-503-5p/FOSL2轴对子宫内膜癌细胞迁移及血管生成的影响
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作者 卢逸静 文红蕾 王静 《中国优生与遗传杂志》 2025年第10期2066-2074,共9页
目的探讨雪松醇调节微小RNA-503-5p(miR-503-5p)/FOS样抗原2(FOSL2)对子宫内膜癌(EC)细胞迁移及血管生成的影响。方法检测EC组织与细胞系中miR-503-5p及FOSL2蛋白表达。使用7.5~240μmol/L的雪松醇处理EC细胞,筛选药物浓度;将HEC-1-A细... 目的探讨雪松醇调节微小RNA-503-5p(miR-503-5p)/FOS样抗原2(FOSL2)对子宫内膜癌(EC)细胞迁移及血管生成的影响。方法检测EC组织与细胞系中miR-503-5p及FOSL2蛋白表达。使用7.5~240μmol/L的雪松醇处理EC细胞,筛选药物浓度;将HEC-1-A细胞分为对照组(Control组)、Cedrol组、Cedrol+inhibitor NC组、Cedrol+miR-503-5p inhibitor组、mimics NC组、miR-503-5p mimics组、miR-503-5p mimics+pcDNA组、miR-503-5p mimics+FOSL2组;分别检测各组细胞miR-503-5p、FOSL2 mRNA表达、细胞增殖、迁移、侵袭及血管生成情况;双荧光素酶报告基因实验验证FOSL2与mi R-503-5p的靶向关系。裸鼠成瘤实验验证雪松醇对EC移植瘤生长的影响。结果EC组织miR-503-5p表达降低,FOSL2 mRNA与蛋白表达升高(P<0.05);选择HEC-1-A细胞及雪松醇药物浓度为60μmol/L进行实验。HEC-1-A细胞经60μmol/L雪松醇处理或miR-503-5p mimics转染后,细胞miR-503-5p表达水平升高,细胞活力、EdU阳性率、划痕愈合率、细胞侵袭数及血管生成数降低(P<0.05);抑制miR-503-5p表达或过表达FOSL2分别可减弱雪松醇或过表达miR-503-5p对EC细胞恶性行为的抑制作用(P<0.05);miR-503-5p可靶向负调节FOSL2表达;裸鼠成瘤实验显示,雪松醇可显著抑制EC移植瘤生长。结论雪松醇可能通过上调miR-503-5p,抑制FOSL2表达,抑制EC细胞增殖、迁移、侵袭及血管生成。 展开更多
关键词 雪松醇 子宫内膜癌细胞 微小RNA-503-5p fos样抗原2 血管生成
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MXene-based thermoelectric fabric integrated with temperature and strain sensing for health monitoring 被引量:1
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作者 Jun Peng Fangqing Ge +4 位作者 Weiyi Han Tao Wu Jinglei Tang Yuning Li Chaoxia Wang 《Journal of Materials Science & Technology》 2025年第9期272-280,共9页
Wearable thermoelectric devices hold significant promise in the realm of self-powered wearable electron-ics,offering applications in energy harvesting,movement tracking,and health monitoring.Nevertheless,developing th... Wearable thermoelectric devices hold significant promise in the realm of self-powered wearable electron-ics,offering applications in energy harvesting,movement tracking,and health monitoring.Nevertheless,developing thermoelectric devices with exceptional flexibility,enduring thermoelectric stability,multi-functional sensing,and comfortable wear remains a challenge.In this work,a stretchable MXene-based thermoelectric fabric is designed to accurately discern temperature and strain stimuli.This is achieved by constructing an adhesive polydopamine(PDA)layer on the nylon fabric surface,which facilitates the subsequent MXene attachment through hydrogen bonding.This fusion results in MXene-based thermo-electric fabric that excels in both temperature sensing and strain sensing.The resultant MXene-based thermoelectric fabric exhibits outstanding temperature detection capability and cyclic stability,while also delivering excellent sensitivity,rapid responsiveness(60 ms),and remarkable durability in strain sens-ing(3200 cycles).Moreover,when affixed to a mask,this MXene-based thermoelectric fabric utilizes the temperature difference between the body and the environment to harness body heat,converting it into electrical energy and accurately discerning the body’s respiratory rate.In addition,the MXene-based ther-moelectric fabric can monitor the state of the body’s joint through its own deformation.Furthermore,it possesses the capability to convert solar energy into heat.These findings indicate that MXene-based ther-moelectric fabric holds great promise for applications in power generation,motion tracking,and health monitoring. 展开更多
关键词 Mxene thermoelectric fabric Temperature sensing Strain sensing Energy harvesting
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IoT Empowered Early Warning of Transmission Line Galloping Based on Integrated Optical Fiber Sensing and Weather Forecast Time Series Data 被引量:1
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作者 Zhe Li Yun Liang +1 位作者 Jinyu Wang Yang Gao 《Computers, Materials & Continua》 SCIE EI 2025年第1期1171-1192,共22页
Iced transmission line galloping poses a significant threat to the safety and reliability of power systems,leading directly to line tripping,disconnections,and power outages.Existing early warning methods of iced tran... Iced transmission line galloping poses a significant threat to the safety and reliability of power systems,leading directly to line tripping,disconnections,and power outages.Existing early warning methods of iced transmission line galloping suffer from issues such as reliance on a single data source,neglect of irregular time series,and lack of attention-based closed-loop feedback,resulting in high rates of missed and false alarms.To address these challenges,we propose an Internet of Things(IoT)empowered early warning method of transmission line galloping that integrates time series data from optical fiber sensing and weather forecast.Initially,the method applies a primary adaptive weighted fusion to the IoT empowered optical fiber real-time sensing data and weather forecast data,followed by a secondary fusion based on a Back Propagation(BP)neural network,and uses the K-medoids algorithm for clustering the fused data.Furthermore,an adaptive irregular time series perception adjustment module is introduced into the traditional Gated Recurrent Unit(GRU)network,and closed-loop feedback based on attentionmechanism is employed to update network parameters through gradient feedback of the loss function,enabling closed-loop training and time series data prediction of the GRU network model.Subsequently,considering various types of prediction data and the duration of icing,an iced transmission line galloping risk coefficient is established,and warnings are categorized based on this coefficient.Finally,using an IoT-driven realistic dataset of iced transmission line galloping,the effectiveness of the proposed method is validated through multi-dimensional simulation scenarios. 展开更多
关键词 Optical fiber sensing multi-source data fusion early warning of galloping time series data IOT adaptive weighted learning irregular time series perception closed-loop attention mechanism
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Sensing accuracy gain,unified performance analysis and optimization in 6G cooperative ISAC systems 被引量:1
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作者 Guangyi Liu Lincong Han +3 位作者 Rongyan Xi Jing Dong Jing Jin Qixing Wang 《Digital Communications and Networks》 2025年第5期1657-1667,共11页
Sixth Generation(6G)mobile communication networks will involve sensing as a new function,with the overwhelming trend of Integrated Sensing And Communications(ISAC).Although expanding the serving range of the networks,... Sixth Generation(6G)mobile communication networks will involve sensing as a new function,with the overwhelming trend of Integrated Sensing And Communications(ISAC).Although expanding the serving range of the networks,there exists performance trade-offbetween communication and sensing,in that they have competitions on the physical resources.Different resource allocation schemes will result in different sensing and communication performance,thus influencing the system’s overall performance.Therefore,how to model the system’s overall performance,and how to optimize it are key issues for ISAC.Relying on the large-scale deployment of the networks,cooperative ISAC has the advantages of wider coverage,more robust performance and good compatibility of multiple monostatic and multistatic sensing,compared to the non-cooperative ISAC.How to capture the performance gain of cooperation is a key issue for cooperative ISAC.To address the aforementioned vital problems,in this paper,we analyze the sensing accuracy gain,propose a unified ISAC performance evaluation framework and design several optimization methods in cooperative ISAC systems.The cooperative sensing accuracy gain is theoretically analyzed via Cramér Rao lower bound.The unified ISAC performance evaluation model is established by converting the communication mutual information to the effective minimum mean squared error.To optimize the unified ISAC performance,we design the optimization algorithms considering three factors:base stations’working modes,power allocation schemes and waveform design.Through simulations,we show the performance gain of the cooperative ISAC system and the effectiveness of the proposed optimization methods. 展开更多
关键词 6G Integrated sensing and communications Cooperative sensing Cramér Rao lower bound Orthogonal frequency division multiplexing
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Multi-scale feature fusion optical remote sensing target detection method 被引量:1
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作者 BAI Liang DING Xuewen +1 位作者 LIU Ying CHANG Limei 《Optoelectronics Letters》 2025年第4期226-233,共8页
An improved model based on you only look once version 8(YOLOv8)is proposed to solve the problem of low detection accuracy due to the diversity of object sizes in optical remote sensing images.Firstly,the feature pyram... An improved model based on you only look once version 8(YOLOv8)is proposed to solve the problem of low detection accuracy due to the diversity of object sizes in optical remote sensing images.Firstly,the feature pyramid network(FPN)structure of the original YOLOv8 mode is replaced by the generalized-FPN(GFPN)structure in GiraffeDet to realize the"cross-layer"and"cross-scale"adaptive feature fusion,to enrich the semantic information and spatial information on the feature map to improve the target detection ability of the model.Secondly,a pyramid-pool module of multi atrous spatial pyramid pooling(MASPP)is designed by using the idea of atrous convolution and feature pyramid structure to extract multi-scale features,so as to improve the processing ability of the model for multi-scale objects.The experimental results show that the detection accuracy of the improved YOLOv8 model on DIOR dataset is 92%and mean average precision(mAP)is 87.9%,respectively 3.5%and 1.7%higher than those of the original model.It is proved the detection and classification ability of the proposed model on multi-dimensional optical remote sensing target has been improved. 展开更多
关键词 multi scale feature fusion optical remote sensing feature map improve target detection ability optical remote sensing imagesfirstlythe target detection feature fusionto enrich semantic information spatial information
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A Flexible‑Integrated Multimodal Hydrogel‑Based Sensing Patch 被引量:1
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作者 Peng Wang Guoqing Wang +4 位作者 Guifen Sun Chenchen Bao Yang Li Chuizhou Meng Zhao Yao 《Nano-Micro Letters》 2025年第7期107-125,共19页
Sleep monitoring is an important part of health management because sleep quality is crucial for restoration of human health.However,current commercial products of polysomnography are cumbersome with connecting wires a... Sleep monitoring is an important part of health management because sleep quality is crucial for restoration of human health.However,current commercial products of polysomnography are cumbersome with connecting wires and state-of-the-art flexible sensors are still interferential for being attached to the body.Herein,we develop a flexible-integrated multimodal sensing patch based on hydrogel and its application in unconstraint sleep monitoring.The patch comprises a bottom hydrogel-based dualmode pressure–temperature sensing layer and a top electrospun nanofiber-based non-contact detection layer as one integrated device.The hydrogel as core substrate exhibits strong toughness and water retention,and the multimodal sensing of temperature,pressure,and non-contact proximity is realized based on different sensing mechanisms with no crosstalk interference.The multimodal sensing function is verified in a simulated real-world scenario by a robotic hand grasping objects to validate its practicability.Multiple multimodal sensing patches integrated on different locations of a pillow are assembled for intelligent sleep monitoring.Versatile human–pillow interaction information as well as their evolution over time are acquired and analyzed by a one-dimensional convolutional neural network.Track of head movement and recognition of bad patterns that may lead to poor sleep are achieved,which provides a promising approach for sleep monitoring. 展开更多
关键词 Multimodal sensing Proximity sensor Pressure sensor Temperature sensor Electrospun nanofibers
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Fabrication and Mechano-sensing Characteristics of Bending Polypyrrole Actuator
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作者 CHEN Jinyou HU Wei 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2025年第1期240-245,共6页
To prepare a conductive polymer actuator with decent performance,a self-built experimental platform for the preparation of polypyrrole film is employed.One of the essential goals is to examine the mechanical character... To prepare a conductive polymer actuator with decent performance,a self-built experimental platform for the preparation of polypyrrole film is employed.One of the essential goals is to examine the mechanical characteristics of the actuator in the presence of various combinations of process parameters,combined with the orthogonal test method of"four factors and three levels".The bending and sensing characteristics of actuators of various sizes are methodically examined using a self-made bending polypyrrole actuator.The functional relationship between the bending displacement and the output voltage signal is established by studying the characteristics of the actuator sensor subjected to various degrees of bending.The experimental results reveal that the bending displacement of the actuator tip almost exhibits a linear variation as a function of length and width.When the voltage reaches 0.8 V,the bending speed of the actuator tends to be stable.Finally,the mechanical properties of the self-assembled polypyrrole actuator are verified by the design and fabrication of the microgripper. 展开更多
关键词 conductive polymer POLYPYRROLE mechanical characteristics actuators sensing characteristics
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A phenylphenthiazide anchored Tb(Ⅲ)-cyclen complex for fluorescent turn-on sensing of ClO^(-) 被引量:1
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作者 Ya-Ping Liu Zhi-Rong Gui +4 位作者 Zhen-Wen Zhang Sai-Kang Wang Wei Lang Yanzhu Liu Qian-Yong Cao 《Chinese Chemical Letters》 2025年第2期269-273,共5页
A phenylphenothiazine anchored Tb(Ⅲ)-cyclen complex PTP-Cy-Tb for hypochlorite ion(ClO^(-))detection has been designed and prepared.PTP-Cy-Tb shows a weak Tb-based emission with AIE-characteristics in aqueous solutio... A phenylphenothiazine anchored Tb(Ⅲ)-cyclen complex PTP-Cy-Tb for hypochlorite ion(ClO^(-))detection has been designed and prepared.PTP-Cy-Tb shows a weak Tb-based emission with AIE-characteristics in aqueous solutions.After addition of ClO^(-),the fluorescence of PTP-Cy-Tb gives a large enhancement for oxidization the thioether to sulfoxide group.The detection limit of PTP-Cy-Tb toward ClO^(-)is as low as 8.85 nmol/L.The sensing mechanism was detailedly investigated by time of flight mass spectrometer(TOF-MS),Fourier transform infrared spectroscopy(FT-IR)and density functional theory(DFT)calculation.In addition,PTP-Cy-Tb has been successfully used for on-site and real-time detection of ClO^(-)in real water samples by using the smartphone-based visualization method and test strips. 展开更多
关键词 Phenylphenothiazine Tb(III)complex AIE Hypochlorite ion sensing
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Collapse of Meilong Expressway as Seen from Space:Detecting Precursors of Failure with Satellite Remote Sensing 被引量:1
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作者 Zhuge Xia Chao Zhou +4 位作者 Wandi Wang Mimi Peng Dalu Dong Xiufeng He Guangchao Tan 《Journal of Earth Science》 2025年第2期835-838,共4页
INTRODUCTION.On May 1st,2024,around 2:10 a.m.,a catastrophic collapse occurred along the Meilong Expressway near Meizhou City,Guangdong Province,China,at coordinates 24°29′24″N and 116°40′25″E.This colla... INTRODUCTION.On May 1st,2024,around 2:10 a.m.,a catastrophic collapse occurred along the Meilong Expressway near Meizhou City,Guangdong Province,China,at coordinates 24°29′24″N and 116°40′25″E.This collapse resulted in a pavement failure of approximately 17.9 m in length and covering an area of about 184.3 m^(2)(Chinanews,2024). 展开更多
关键词 failure detection satellite remote sensing pavement failure Meilong Expressway meilong expressway COLLAPSE precursors
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Coupling Multi-Source Satellite Remote Sensing and Meteorological Data to Discriminate Yellow Rust and Fusarium Head Blight in Winter Wheat 被引量:1
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作者 Qi Sheng Huiqin Ma +4 位作者 Jingcheng Zhang Zhiqin Gui Wenjiang Huang Dongmei Chen Bo Wang 《Phyton-International Journal of Experimental Botany》 2025年第2期421-440,共20页
Yellow rust(Puccinia striiformis f.sp.Tritici,YR)and fusarium head blight(Fusarium graminearum,FHB)are the two main diseases affecting wheat in the main grain-producing areas of East China,which is common for the two ... Yellow rust(Puccinia striiformis f.sp.Tritici,YR)and fusarium head blight(Fusarium graminearum,FHB)are the two main diseases affecting wheat in the main grain-producing areas of East China,which is common for the two diseases to appear simultaneously in some main production areas.It is necessary to discriminate wheat YR and FHB at the regional scale to accurately locate the disease in space,conduct detailed disease severity monitoring,and scientific control.Four images on different dates were acquired from Sentinel-2,Landsat-8,and Gaofen-1 during the critical period of winter wheat,and 22 remote sensing features that characterize the wheat growth status were then calculated.Meanwhile,6 meteorological parameters that reflect the wheat phenological information were also obtained by combining the site meteorological data and spatial interpolation technology.Then,the principal components(PCs)of comprehensive remote sensing and meteorological features were extracted with principal component analysis(PCA).The PCs-based discrimination models were established to map YR and FHB damage using the random forest(RF)and backpropagation neural network(BPNN).The models’performance was verified based on the disease field truth data(57 plots during the filling period)and 5-fold cross-validation.The results revealed that the PCs obtained after PCA dimensionality reduction outperformed the initial features(IFs)from remote sensing and meteorology in discriminating between the two diseases.Compared to the IFs,the average area under the curve for both micro-average and macro-average ROC curves increased by 0.07 in the PCs-based RF models and increased by 0.16 and 0.13,respectively,in the PCs-based BPNN models.Notably,the PCs-based BPNN discrimination model emerged as the most effective,achieving an overall accuracy of 83.9%.Our proposed discrimination model for wheat YR and FHB,coupled with multi-source remote sensing images and meteorological data,overcomes the limitations of a single-sensor and single-phase remote sensing information in multiple stress discrimination in cloudy and rainy areas.It performs well in revealing the damage spatial distribution of the two diseases at a regional scale,providing a basis for detailed disease severity monitoring,and scientific prevention and control. 展开更多
关键词 Winter wheat yellow rust(YR) fusarium head blight(FHB) DISCRIMINATION remote sensing and meteorology
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Praseodymium-organic framework with 4,4′-oxybis(benzoic acid):Rare broken layer structure,antibacterial activity,and sensing for Cd^(2+)ions
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作者 CUI Peipei ZHENG Yawen +2 位作者 LI Pan GUAN Peiyan QIAN Zhaohong 《无机化学学报》 北大核心 2025年第8期1641-1649,共9页
A novel 3D metal-organic framework(MOF)[Pr_(2)(L)_(3)(H_(2)O)5·H_(2)O]n(Pr-1),(H_(2)L=4,4'-oxybis(benzoic acid))with a rare structure of broken layer net,was constructed under the condition of solvothermal sy... A novel 3D metal-organic framework(MOF)[Pr_(2)(L)_(3)(H_(2)O)5·H_(2)O]n(Pr-1),(H_(2)L=4,4'-oxybis(benzoic acid))with a rare structure of broken layer net,was constructed under the condition of solvothermal synthesis.The struc-ture and crystal net were analyzed and characterized.This rod net of Pr-1 is new to both RCSR and ToposPro data-bases,and is named as rn-12 as suggested.Due to the luminescent properties of H_(2)L and Pr(Ⅲ),the solid-state fluo-rescence property and sensing performance(solvents and metal ions)of Pr-1 were investigated.The sensing experi-ments indicated that Pr-1 could act as a fluorescence sensor to detect Cd^(2+)ions with good sensitivity.In addition,antibacterial activities show that Pr-1 exhibited stronger antibacterial activity against Escherichia coli(E.coli),Staphylococcus aureus(S.aureus),and Bacillus subtilis(B.subtilis)compared to synthetic materials. 展开更多
关键词 dicarboxylate ligand crystal net luminescence sensing antibacterial activity
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ECD-Net: An Effective Cloud Detection Network for Remote Sensing Images
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作者 Hui Gao Xianjun Du 《Journal of Computer and Communications》 2025年第1期1-14,共14页
Cloud detection is a critical preprocessing step in remote sensing image processing, as the presence of clouds significantly affects the accuracy of remote sensing data and limits its applicability across various doma... Cloud detection is a critical preprocessing step in remote sensing image processing, as the presence of clouds significantly affects the accuracy of remote sensing data and limits its applicability across various domains. This study presents an enhanced cloud detection method based on the U-Net architecture, designed to address the challenges of multi-scale cloud features and long-range dependencies inherent in remote sensing imagery. A Multi-Scale Dilated Attention (MSDA) module is introduced to effectively integrate multi-scale information and model long-range dependencies across different scales, enhancing the model’s ability to detect clouds of varying sizes. Additionally, a Multi-Head Self-Attention (MHSA) mechanism is incorporated to improve the model’s capacity for capturing finer details, particularly in distinguishing thin clouds from surface features. A multi-path supervision mechanism is also devised to ensure the model learns cloud features at multiple scales, further boosting the accuracy and robustness of cloud mask generation. Experimental results demonstrate that the enhanced model achieves superior performance compared to other benchmarked methods in complex scenarios. It significantly improves cloud detection accuracy, highlighting its strong potential for practical applications in cloud detection tasks. 展开更多
关键词 Deep Learning Remote sensing Cloud Detection MSDA MHSA
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Web-Based Platform and Remote Sensing Technology for Monitoring Mangrove Ecosystem
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作者 Evelyn Anthony Rodriguez John Edgar Sualog Anthony +2 位作者 Randy Anthony Quitain Wilma Cledera Delos Santos Ernesto Jr. Benda Rodriguez 《Open Journal of Ecology》 2025年第1期1-10,共10页
Remote sensing and web-based platforms have emerged as vital tools in the effective monitoring of mangrove ecosystems, which are crucial for coastal protection, biodiversity, and carbon sequestration. Utilizing satell... Remote sensing and web-based platforms have emerged as vital tools in the effective monitoring of mangrove ecosystems, which are crucial for coastal protection, biodiversity, and carbon sequestration. Utilizing satellite imagery and aerial data, remote sensing allows researchers to assess the health and extent of mangrove forests over large areas and time periods, providing insights into changes due to environmental stressors like climate change, urbanization, and deforestation. Coupled with web-based platforms, this technology facilitates real-time data sharing and collaborative research efforts among scientists, policymakers, and conservationists. Thus, there is a need to grow this research interest among experts working in this kind of ecosystem. The aim of this paper is to provide a comprehensive literature review on the effective role of remote sensing and web-based platform in monitoring mangrove ecosystem. The research paper utilized the thematic approach to extract specific information to use in the discussion which helped realize the efficiency of digital monitoring for the environment. Web-based platforms and remote sensing represent a powerful tool for environmental monitoring, particularly in the context of forest ecosystems. They facilitate the accessibility of vital data, promote collaboration among stakeholders, support evidence-based policymaking, and engage communities in conservation efforts. As experts confront the urgent challenges posed by climate change and environmental degradation, leveraging technology through web-based platforms is essential for fostering a sustainable future for the forests of the world. 展开更多
关键词 Mangrove Ecosystems MONITORING Remote sensing Web-Based Platform
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Ultrastrong silk fabric ionogel-sensor for strain/temperature/tactile multi-mode sensing
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作者 Shu Wang Jiangling Ning +9 位作者 Jianyu Pu Changjie Wei Yuping Yuan Songqi Yao Yuantao Zhang Ziwen Jing Chenxing Xiang Xinglong Gong Zhi Li Ning Hu 《Nano Materials Science》 2025年第3期316-325,共10页
Ionogels have demonstrated substantial applications in smart wearable systems,soft robotics,and biomedical engineering due to the exceptional ionic conductivity and optical transparency.However,achieving ionogels with... Ionogels have demonstrated substantial applications in smart wearable systems,soft robotics,and biomedical engineering due to the exceptional ionic conductivity and optical transparency.However,achieving ionogels with desirable mechanical properties,environmental stability,and multi-mode sensing remains challenging.Here,we propose a simple strategy for the fabrication of multifunctional silk fabric-based ionogels(BSFIGs).The resulting fabric ionogels exhibits superior mechanical properties,with high tensile strength(11.3 MPa)and work of fracture(2.53 MJ/m^(3)).And its work of fracture still has 1.42 MJ/m^(3)as the notch increased to 50%,indicating its crack growth insensitivity.These ionogels can be used as sensors for strain,temperature,and tactile multimode sensing,demonstrating a gauge factor of 1.19 and a temperature coefficient of resistance of3.17/℃^(-1).Furthermore,these ionogels can be used for the detection of different roughness and as touch screens.The ionogels also exhibit exceptional optical transmittance and environmental stability even at80℃.Our scalable fabrication process broadens the application potential of these multifunctional ionogels in diverse fields,from smart systems to extreme environments. 展开更多
关键词 Silk fabric ionogel Mechanical properties Strain sensing Temperature sensing Tactile sensing
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Block sparse compressed sensing with frames:Null space property and l_(2)/l_(q)(0
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作者 WU Fengong ZHONG Penghong QIN Yuehai 《中山大学学报(自然科学版)(中英文)》 北大核心 2025年第3期173-182,共10页
This paper explores the recovery of block sparse signals in frame-based settings using the l_(2)/l_(q)-synthesis technique(0<q≤1).We propose a new null space property,referred to as block D-NSP_(q),which is based ... This paper explores the recovery of block sparse signals in frame-based settings using the l_(2)/l_(q)-synthesis technique(0<q≤1).We propose a new null space property,referred to as block D-NSP_(q),which is based on the dictionary D.We establish that matrices adhering to the block D-NSP_(q)condition are both necessary and sufficient for the exact recovery of block sparse signals via l_(2)/l_(q)-synthesis.Additionally,this condition is essential for the stable recovery of signals that are block-compressible with respect to D.This D-NSP_(q)property is identified as the first complete condition for successful signal recovery using l_(2)/l_(q)-synthesis.Furthermore,we assess the theoretical efficacy of the l2/lq-synthesis method under conditions of measurement noise. 展开更多
关键词 Compressed sensing block sparse l2/lq-synthesis method null space property
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Structural regulation of alkynyl-based covalent organic frameworks for multi-stimulus fluorescence sensing
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作者 Xinrui Chen Wenjian Huang +2 位作者 Xiaoyang Zhao Songyao Zhang Xinrui Miao 《Chinese Journal of Structural Chemistry》 2025年第7期25-34,共10页
Stimuli-responsive two-dimensional (2D) covalent organic frameworks (COFs) with precise structures and permanent porosity have been employed as platforms for sensors. The slight change of backbones inside frameworks l... Stimuli-responsive two-dimensional (2D) covalent organic frameworks (COFs) with precise structures and permanent porosity have been employed as platforms for sensors. The slight change of backbones inside frameworks leads to different electronic states by external stimuli, such as solvent, pH, and water. Herein, we introduced an alkynyl-based building block (ETBA) with high planarity to synthesize two imine-based alkynyl-COFs (ETBA-TAPE-COF and ETBA-PYTA-COF) with high yield, good crystallinity, and chemical stability. Due to the presence of acetylene bonds, ETBA-TAPE-COF does not adopt the completely overlapping AA stacking mode. Slight interlayer displacement occurs along the parallel direction relative to the acetylene linkages, which facilitates lower configurational energy. Additionally, the introduction of pyrene group contributes to high π-electron mobility of ETBA-PYTA-COF. The interactions between electron-withdrawing group (ETBA) and electron-donating group (PYTA) during the processes of protonation and intramolecular charge transfer (ICT) endow ETBA-PYTA-COF with excellent acidochromic and solvatochromic properties, respectively. Based on this, a fluorescence sensor is successfully established, which can be used for rapid response to trace amounts of water in organic solvents. In contrast, ETBA-TAPE-COF does not exhibit these photophysical properties due to its higher HOMO–LUMO gap compared to ETBA-PYTA-COF. This work proposes a new strategy for designing and preparing COFs with unique photophysical properties without introducing additional functional groups. 展开更多
关键词 ALKYNES Covalent organic frameworks Low pH sensing Photoluminescent sensing SOLVATOCHROMISM Water sensing
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Carbon Dots-Modified Hollow Mesoporous Photonic Crystal Materials for Sensitivityand Selectivity-Enhanced Sensing of Chloroform Vapor
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作者 Junchen Liu Ji Liu +9 位作者 Zhipeng Li Liupeng Zhao Tianshuang Wang Xu Yan Fangmeng Liu Xiaomin Li Qin Li Peng Sun Geyu Lu Dongyuan Zhao 《Nano-Micro Letters》 2025年第4期381-398,共18页
Chloroform and other volatile organic pollutants have garnered widespread attention from the public and researchers,because of their potential harm to the respiratory system,nervous system,skin,and eyes.However,resear... Chloroform and other volatile organic pollutants have garnered widespread attention from the public and researchers,because of their potential harm to the respiratory system,nervous system,skin,and eyes.However,research on chloroform vapor sensing is still in its early stages,primarily due to the lack of specific recognition motif.Here we report a mesoporous photonic crystal sensor incorporating carbon dots-based nanoreceptor(HMSS@CDs-PCs)for enhanced chloroform sensing.The colloidal PC packed with hollow mesoporous silica spheres provides an interconnected ordered macro-meso-hierarchical porous structure,ideal for rapid gas sensing utilizing the photonic bandgap shift as the readout signal.The as-synthesized CDs with pyridinic-N-oxide functional groups adsorbed in the hollow mesoporous silica spheres are found to not only serve as the chloroform adsorption sites,but also a molecular glue that prevents crack formation in the colloidal PC.The sensitivity of HMSS@CDs-PCs sensor is 0.79 nm ppm^(-1)and an impressively low limit of detection is 3.22 ppm,which are the best reported values in fast-response chloroform vapor sensor without multi-signal assistance.The positive response time is 7.5 s and the negative response time 9 s.Furthermore,relatively stable sensing can be maintained within a relative humidity of 20%-85%RH and temperature of 25-55℃.This study demonstrates that HMSS@CDs-PCs sensors have practical application potential in indoor and outdoor chloroform vapor detection. 展开更多
关键词 Carbon dots Photonic crystal sensors Sensitivity-enhanced sensing Selectivity-enhanced sensing Chloroform vapor sensing
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温针灸对膝骨关节炎模型兔软骨下骨c-Fos、c-Jun mRNA表达的影响
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作者 陈文清 吴靖 +1 位作者 肖阳 洪昆达 《湖南中医杂志》 2025年第11期155-160,共6页
目的:观察温针灸对膝骨关节炎(Knee Osteoarthritis,KOA)模型兔软骨下骨Fos原癌基因(Fos proto-oncogene,c-Fos)与Jun原癌基因(Jun proto-oncogene,c-Jun)mRNA表达的影响,探讨温针灸治疗KOA的可能作用机制。方法:选取18只普通级新西兰兔... 目的:观察温针灸对膝骨关节炎(Knee Osteoarthritis,KOA)模型兔软骨下骨Fos原癌基因(Fos proto-oncogene,c-Fos)与Jun原癌基因(Jun proto-oncogene,c-Jun)mRNA表达的影响,探讨温针灸治疗KOA的可能作用机制。方法:选取18只普通级新西兰兔(雌雄各半),将其随机分为正常组、模型组和温针灸组,每组各6只,模型组与温针灸组采用4%木瓜蛋白酶关节腔注射法建立KOA模型。造模结束后开始干预,温针灸组取左侧内膝眼、犊鼻穴,行温针灸干预,20 min/次,隔天1次,连续干预4周;正常组和模型组仅固定、不干预。实验期间观察兔的一般情况;干预结束后,取左侧膝关节,使用番红O-固绿染色观察各组软骨及软骨下骨形态结构;实时荧光定量PCR(quantitative real-time PCR,qPCR)检测各组软骨下骨组织中c-Fos、c-Jun mRNA的表达情况。结果:与正常组比较,模型组兔一般情况较差,膝关节软骨组织表面粗糙,结构完整性被破坏,潮线模糊,骨小梁变细,稀疏,连续性中断,骨小梁表面积及表面积百分比降低(P<0.01),软骨下骨组织c-Fos、c-Jun mRNA相对表达量显著升高(P<0.01)。与模型组比较,温针灸组兔一般情况尚可,膝关节软骨及软骨下骨病理学表现有明显改善,潮线清晰,骨小梁增粗、增多,骨小梁表面积及表面积百分比升高(P<0.01);软骨下骨组织c-Fos、c-Jun mRNA相对表达量显著降低(P<0.01)。结论:温针灸可能通过下调c-Fos、c-Jun mRNA的表达,抑制破骨细胞的活性,从而减少软骨下骨吸收,调节软骨下骨重塑平衡,减轻软骨下骨损伤,进而延缓KOA的发展。 展开更多
关键词 膝骨关节炎 温针灸 C-fos C-JUN 实验研究
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