Objective To evaluate the influence of the tissue specificity of the acupoints （different meridians, tissues and nerve segments） on the frequency, intensity and current flow output in association with electroacupunc...Objective To evaluate the influence of the tissue specificity of the acupoints （different meridians, tissues and nerve segments） on the frequency, intensity and current flow output in association with electroacupuncture （EA） sensations. Methods Twenty one volunteers received EA. According to the tissue specificities of acupoints, 5 acupoint pairs were selected, named Zúsānlǐ （足三里 ST 36） vs Yánglíngquán （阳陵泉 GB 34, different meridians）, Nèiguān （内关 PC 6） vs Dàlíng （大陵 PC 7, different tissues）, Zúsānlǐ （足三里 ST 36） vs Shuǐdào （水道 ST 28, different nerve segments）, Guānyuán （关元 CV 4） vs Zhōngwǎn （中脘 CV 12, different nerve segments）, and Zúsānlǐ （足三里 ST 36） vs Guānyuán （关元 CV 4, different meridians, tissues and nerve segments）. The electric frequency was 15 Hz. The electric current was under the subject’s tolerance without sharp pain induced. EA lasted 90 s with 3 discontinuities. The sensations, such as soreness, numbness, fullness/distention, heaviness, tingling, pressure, dull pain, hotness and coldness were recorded as well as the current flow output in association with the needling sensations. The differences in the frequency, intensity and current flow output relevant with the needling sensations were compared among the different acupoint pairs. Results There were no significant differences in the frequency of the needling sensations among the different acupoint pairs （all P〉0.05）. Of 9 different sensations of EA, fullness/distention, numbness and soreness presented the most commonly and remarkably; heaviness, pressure and tingling were on the second top; dull pain, hotness and coldness occurred at the lower frequency. There were the differences in the intensity of some needling sensations among the acupoint pairs, in which, the intensity of soreness, fullness/distention and heaviness was stronger at Zúsānlǐ （足三里 ST 36） vs Shuǐdào （水道 ST 28） （all P〈0.05）; the intensity of fullness / distention, and numbness was stronger at Zúsānlǐ （足三里 ST 36） vs Guānyuán （关元 CV 4） （P〈0.01）; the intensity of fullness/distention was stronger at Guānyuán （关元 CV 4） vs Zhōngwǎn （中脘 CV 12） （P〈0.05）. The current flow output of EA was similar among the acupoint pairs （all P〉0.05）. Conclusion In the situation that there is no obvious difference in the current flow output associated with EA sensations, the frequency of EA sensations does not relevant apparently with the different tissues. The difference in the intensity of the needling sensations among the different acupoints is probably relevant with the nerve segments at the acupoint locations. The frequency and the intensity of the different needling sensations at the same acupoint are relatively stable at the different times of EA.展开更多
Combining two non-contact testing instruments of a three-dimensional body measure system and an infrared camera, the entrapped air gap under clothing and the clothing surface temperature distribution were measured wit...Combining two non-contact testing instruments of a three-dimensional body measure system and an infrared camera, the entrapped air gap under clothing and the clothing surface temperature distribution were measured without interfering the air gap state. It was discussed the effect of different air gap size on subjective clothing sensation. At the same time, taken the subjective sensations of moisture, adhesiveness and mugginess from the lower back as example, the relationship among the subjective evaluation, the air gap size and the clothing surface temperature were analyzed.展开更多
The term phantom sensations(PS) refers to sensations in a missing body part. They are almost universal in amputees and can be both painful and not painful. Although PS have been frequently described in limb amputees, ...The term phantom sensations(PS) refers to sensations in a missing body part. They are almost universal in amputees and can be both painful and not painful. Although PS have been frequently described in limb amputees, they can also occur in other clinical conditions and several pathophysiological interpretations have been proposed, with a predominance of theories based on a central origin. Actually, different mechanisms are able to create a phantom sensation. After an amputation, PS are frequently generated by the genesis of ectopic action potentials in the interrupted nerve fibers but the PS generator can also be more proximal. Sometimes PS are not created by the stimulation of somatosensory fibers with a missing territory, but they can be the result of central sensitization or neuroplastic changes that allow for the convergence of impulses coming from different body parts(referred sensations), one of which is missing. In conclusion, PS can be generated by both neuropathic and non-neuropathic mechanisms developed in the amputated body part or in other parts of the nervous system. Since these mechanisms are not pathognomonic of amputation there are no hidden ghosts to look for in phantom sensations. The only interpretative rule is just to follow the pathophysiological principles.展开更多
The goal of this preliminary study was to examine the effect of participants’ sexes on the temporal sequence of dominant sensations elicited by fruit-flavored teas. Twelve healthy young adults were assigned to male (...The goal of this preliminary study was to examine the effect of participants’ sexes on the temporal sequence of dominant sensations elicited by fruit-flavored teas. Twelve healthy young adults were assigned to male (n = 6) and female (n = 6) groups. Both groups were evaluated for four sensations using four fruit-flavored teas with 0.05 M sucrose using the temporal dominance of sensations (TDS) method. Only two sensations, sweetness and fruitiness, were consistently reported in the two groups. The male group first reported fruitiness and then sweetness as the dominant sensation following ingestion of the samples. Conversely, the female group reported these two dominant sensations in the reverse order. Significant dominant durations between the two sensations largely varied among the samples in both groups. These results suggest that there are sex-based differences in the temporal sequence of dominant sensations elicited by fruit-flavored teas as evaluated by the TDS method.展开更多
Leakage currents, tiny currents flowing from an everyday-life appliance through the body to the ground, can cause a non-adequate perception （called electrocutaneous sensation, ECS） or even pain and should be avoided...Leakage currents, tiny currents flowing from an everyday-life appliance through the body to the ground, can cause a non-adequate perception （called electrocutaneous sensation, ECS） or even pain and should be avoided. Safety standards for low-frequency range are based on experimental results of current thresholds of electrocutaneous sensations, which however show a wide range between about 50 pA （rms） and 1000 μA （rms）. In order to be able to explain these differences, the perception threshold was measured repeatedly in experiments with test persons under identical experimental setup, but by means of different methods （measuring strategies）, namely： direct adjustment, classical threshold as amperage of 50% perception probability, and confidence rating procedure of signal detection theory. The current is injected using a I cm2 electrode at the highly touch sensitive part of the index fingertip. These investigations show for the first time that the threshold of electrocutaneous sensations is influenced both by adaptation to the non-adequate stimulus and individual, emotional factors. Theretbre, classical methods, on which the majority of the safety investigations are based, cannot be used to determine a leakage current threshold. The confidence rating procedure of the modem signal detection theory yields a value of 179.5 μA （rms） at 50 Hz power supply net frequency as the lower end of the 95% confidence range considering the variance in the investigated group. This value is expected to be free of adaptation influences, and is distinctly lower than the European limits and supports the stricter regulations of Canada and USA.展开更多
Spinal cord injury(SCI) often results in permanent dysfunction of locomotion,sensation,and autonomic regulation,imposing a substantial burden on both individuals and society(Anjum et al.,2020).SCI has a complex pathop...Spinal cord injury(SCI) often results in permanent dysfunction of locomotion,sensation,and autonomic regulation,imposing a substantial burden on both individuals and society(Anjum et al.,2020).SCI has a complex pathophysiology:an initial primary injury(mechanical trauma,axonal disruption,and hemorrhage) is followed by a progressive secondary injury cascade that involves ischemia,neuronal loss,and inflammation.Given the challenges in achieving regeneration of the injured spinal cord,neuroprotection has been at the forefront of clinical research.展开更多
Objective:To investigate the effects of different acupuncture manipulations on Deqi sensations and surface myoelectricity,and explore the correlation between Deqi sensations and needling manipulations.Methods:Forty-fi...Objective:To investigate the effects of different acupuncture manipulations on Deqi sensations and surface myoelectricity,and explore the correlation between Deqi sensations and needling manipulations.Methods:Forty-five healthy participants accepted twirling,lifting-thrusting,and twirling plus lifting-thrusting manipulanions at right Zusanli(ST 36),respectively.The acupuncturist’s and participants’Deqi sensations were collected by MGH Acupuncture Sensation Scale(MASS).The intensity and occurrence rate of soreness,dull pain,pressure,heaviness,fullness,numbness,sharp pain,warmth,coolness,and throbbing feelings of participants,and tightness,smooth,and tangle feelings of acupuncturist were measured.The correlation between the acupuncturist’s and participant’s Deqi sensations was analyzed.Surface electromyogram(EMG)was recorded before,during and after needling in 30 participants.The integrated EMG(iEMG),mean power frequency(MPF)and media frequency(MF)were analyzed.Result:Both fullness and soreness of participants and tightness of acupuncturist were the most frequently occurred ones.A positive correlation between participants’fullness and acupuncturist’s tightness was observed during the three aforementioned needling manipulations(P<0.05,OR>1).Almost all the needling sensations measured in the present study could be induced by the three needling manipulations.However,strength of Deqi sensations was exhibited as lifting-thrusting>twirling plus lifting-thrusting>twirling according to MASS index.The i EMG values were increased and MPF,MF values were decreased during needling compaired to those before needling,especially during lifting-thrusting(P<0.01).Conclusions:The intensity and occurrence rate of the different Deqi sensations induced by different needling manipulations were basically similar.The fullness and soreness were both the most frequently induced Deqi sensations.The strongest Deqi sensation could be induced by lifting-thrusting manipulation.There is a positive correlation between participants’fullness and acupuncturist’s tightness during the three needling manipulations.The myoelectricity around the acupoint is related to Deqi responses.(Registration No.AMCTR-IOR-20000314).展开更多
Implantable cardioverter defibrillators(ICDs)represent an established therapeutic strategy for the prevention of sudden cardiac death and reduction of mortality in high-risk patients,while ICDs with cardiac resynchron...Implantable cardioverter defibrillators(ICDs)represent an established therapeutic strategy for the prevention of sudden cardiac death and reduction of mortality in high-risk patients,while ICDs with cardiac resynchronization therapy defibrillators improve morbidity,quality of life,and mortality in eligible patients with heart failure who are on optimal medical therapy.However,these devices may adversely affect the patients’psychological status after the delivery of shock therapies or even because of the fear of impending therapy.On the other hand,the potential of effective treatment of malignant arrhythmias may provide a‘safety’sensation in most treated patients without significant impairment in the quality of life during periods of clinical stability.During the past few years,an increasing number of reports have investigated psychological distress,including depression and anxiety status in ICD/cardiac resynchronization therapy defibrillator recipients.However,heterogeneous results have been reported while data on the variation of these psychological indexes over time in implanted patients are quite limited.Several intrinsic and extrinsic factors affect the psychological status of these patients while variations of these disturbances in specific populations are evident.Factors that seem to be associated with a greater risk for depression and anxiety in this setting include female gender,younger age,and device shock therapies.Moreover,depression and anxiety may have an adverse impact on patients’clinical outcomes exacerbating heart failure and increasing the arrhythmic risk.In this brief review article,we provide a concise and critical overview of the current literature on this topic,and we also discuss unresolved and conflicting issues delineating future perspectives.展开更多
With the rise of artificial intelligence(AI),neuromorphic sensory systems that emulate the five basic human sensations including tactility,audition,olfaction,gustation,and vision have attracted significant attention.I...With the rise of artificial intelligence(AI),neuromorphic sensory systems that emulate the five basic human sensations including tactility,audition,olfaction,gustation,and vision have attracted significant attention.In particular,research on integrating sensors with artificial synapses is being carried out extensively.These studies offer valuable opportunities for making another breakthrough in AI technology,including autonomous systems,real-time monitoring systems,and human-machine interactions.In this review,we introduce promising reports of neuromorphic sensory systems.Specifically,the core sensing material,device architecture,fabrication process,and applications of the proposed systems are presented in detail.Finally,the unsolved challenges and the prospects of neuromorphic sensory systems are discussed.展开更多
National Theatre of China Copenhagen Date:February 21-March 2,2025 Venue:National Center for the Performing Arts Copenhagen,a two-act play written by Michael Frayn and first performed in 1998,has won numerous awards,i...National Theatre of China Copenhagen Date:February 21-March 2,2025 Venue:National Center for the Performing Arts Copenhagen,a two-act play written by Michael Frayn and first performed in 1998,has won numerous awards,including a Tony Award for Best Play,creating a sensation in Europe and the United States.The play has attracted many audiences with its unique structure,mysterious plot,and engaging narrative.It is a dialogue among three dead souls:German scientist Werner Heisenberg,Danish scientist Neils Bohr,and his wife Margrethe.It pieces together a mystery in modern scientific history,of a real-life meeting that took place in 1941 in Copenhagen,at the height of Nazi power,which affected the development of the atomic bomb.展开更多
Dear Editor,Recurrent corneal erosion(RCE)is a common clinical condition characterized by repeated episodes of eye redness,pain,foreign-body sensation,photophobia,and tearing[1].The causes of RCE include trauma,chemic...Dear Editor,Recurrent corneal erosion(RCE)is a common clinical condition characterized by repeated episodes of eye redness,pain,foreign-body sensation,photophobia,and tearing[1].The causes of RCE include trauma,chemical and thermal injuries,previous herpetic keratitis,epithelial basement membrane dystrophy,and systemic conditions like epidermolysis bullosa[2-3].展开更多
Dear Editor,Transcranial Magnetic Stimulation(TMS)has emerged as a promising therapeutic tool for various neurological and psychiatric conditions[1-3].However,despite its potential benefits,TMS is not without its disc...Dear Editor,Transcranial Magnetic Stimulation(TMS)has emerged as a promising therapeutic tool for various neurological and psychiatric conditions[1-3].However,despite its potential benefits,TMS is not without its discomfort issues[4,5],which are mainly related to target location,stimulus intensity,and treatment duration.The discomfort associated with TMS arises from several factors,including the physical sensations experienced during the procedure and potential adverse effects on the scalp and surrounding tissues.展开更多
Objective With the development of science of acupuncture and moxibustion, people have, in the knowledge of ＂deqi＂, developed from subjective level to the quantitative level, and discovered many factors influencing t...Objective With the development of science of acupuncture and moxibustion, people have, in the knowledge of ＂deqi＂, developed from subjective level to the quantitative level, and discovered many factors influencing the ＂deqi＂ of acupuncture. In this report, the relationship between ＂deqi＂ and these factors was explored in terms of different acupuncture methods and quantity and depth of stimulus. Methods Ancient literature about ＂deqi＂, as well as related literature for clinical and basic research on ＂deqi＂ in recent 10 years were systematically collected. Results （1） Cerebral functional imaging technology and the scale of ＂deqi＂ were the most common quantitative indexes for ＂deqi＂ in recent 10 years. （2） There were many factors influencing ＂deqi＂ in acupuncture, which involved personal physiological status, nature of disease, anatomical features under the acupoint, different acupuncture methods, quantity and depth of stimulus, etc. Different acupuncture methods, quantity and depth of stimulus would bring different influences on and mechanisms of ＂deqi＂. Conclusion （1） ＂Deqi＂ is not equal to needling sensation; （2） recessive needling sensation should be re-recognized; （3） the sensation of doctor should be paid attention; （4） The meaning of ＂deqi＂ should be re-defined and re-understood.展开更多
In order to find out how the climatic characteristics affect people＇s adaptability to thermal environments,experimental studies in a climate chamber are conducted on the effects of transition seasons（from spring to ...In order to find out how the climatic characteristics affect people＇s adaptability to thermal environments,experimental studies in a climate chamber are conducted on the effects of transition seasons（from spring to summer）and the occupants＇ native areas on indoor thermal sensations.Results reveal that people＇s tolerances to cool and warm indoor environments are different in the transition season.When the outdoor temperature is higher,the occupants have a weaker tolerance to a cool indoor environment,but a stronger tolerance to a warm indoor environment.Besides,it is found that the occupants＇ thermal sensations depend on both the climatic characteristics of the season and their native areas.The people from southern China present a greater tolerance to both warm and cool indoor environments than those from northern China.The reason can be explained according to the occupants＇ adaptability to the climatic characteristics and the indoor thermal environments of their native areas in different climate zones.展开更多
Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of amputees.Current studies focus on tactile feedback,while the lack of appropriate mu...Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of amputees.Current studies focus on tactile feedback,while the lack of appropriate multisensory feedback,especially proprioception feedback,limits the grasping quality.Additionally,a typical non-invasive stimulation scheme for sensation feedback uses stimulation on the stationary site of the skin continuously,which can lead to fatigue and adaptation of sensation,further reduces the feedback consistency,and increases the cognitive burden for the subject.Considering the sensitivity and modality matching of sensation,this study presented a multimodal sensations feedback scheme based on hybrid static-dynamic sensation elicited by multisite Transcutaneous Electrical Nerve Stimulation(TENS)to deliver grasping force and joint position feedback.In the proposed scheme,stimulation of single electrode produced only in-loco tactile sensation under the electrode,and the sensation intensity was adjusted according to grasping force;sequential activation of multi-electrodes produced an illusion dynamic sensation of a stimulus moving,and the velocity and direction of movement were adjusted according to finger joint position.Psychometric test results demonstrated the identifiability of stimulus in the proposed scheme.Further,prosthetic hand closed-loop grasping tasks evaluate the effectiveness of the proposed feedback scheme.The results showed that the proposed feedback scheme could substantially improve the grasping accuracy and efficiency.In addition,the study outcomes also demonstrated the benefit of artificial proprioception feedback in grasping rapidity and security.展开更多
基金Supported by National Natural Science Fund Project: 30870668NIH/NCCAM subsidized project: F 05 AT 03022-01-04
文摘Objective To evaluate the influence of the tissue specificity of the acupoints （different meridians, tissues and nerve segments） on the frequency, intensity and current flow output in association with electroacupuncture （EA） sensations. Methods Twenty one volunteers received EA. According to the tissue specificities of acupoints, 5 acupoint pairs were selected, named Zúsānlǐ （足三里 ST 36） vs Yánglíngquán （阳陵泉 GB 34, different meridians）, Nèiguān （内关 PC 6） vs Dàlíng （大陵 PC 7, different tissues）, Zúsānlǐ （足三里 ST 36） vs Shuǐdào （水道 ST 28, different nerve segments）, Guānyuán （关元 CV 4） vs Zhōngwǎn （中脘 CV 12, different nerve segments）, and Zúsānlǐ （足三里 ST 36） vs Guānyuán （关元 CV 4, different meridians, tissues and nerve segments）. The electric frequency was 15 Hz. The electric current was under the subject’s tolerance without sharp pain induced. EA lasted 90 s with 3 discontinuities. The sensations, such as soreness, numbness, fullness/distention, heaviness, tingling, pressure, dull pain, hotness and coldness were recorded as well as the current flow output in association with the needling sensations. The differences in the frequency, intensity and current flow output relevant with the needling sensations were compared among the different acupoint pairs. Results There were no significant differences in the frequency of the needling sensations among the different acupoint pairs （all P〉0.05）. Of 9 different sensations of EA, fullness/distention, numbness and soreness presented the most commonly and remarkably; heaviness, pressure and tingling were on the second top; dull pain, hotness and coldness occurred at the lower frequency. There were the differences in the intensity of some needling sensations among the acupoint pairs, in which, the intensity of soreness, fullness/distention and heaviness was stronger at Zúsānlǐ （足三里 ST 36） vs Shuǐdào （水道 ST 28） （all P〈0.05）; the intensity of fullness / distention, and numbness was stronger at Zúsānlǐ （足三里 ST 36） vs Guānyuán （关元 CV 4） （P〈0.01）; the intensity of fullness/distention was stronger at Guānyuán （关元 CV 4） vs Zhōngwǎn （中脘 CV 12） （P〈0.05）. The current flow output of EA was similar among the acupoint pairs （all P〉0.05）. Conclusion In the situation that there is no obvious difference in the current flow output associated with EA sensations, the frequency of EA sensations does not relevant apparently with the different tissues. The difference in the intensity of the needling sensations among the different acupoints is probably relevant with the nerve segments at the acupoint locations. The frequency and the intensity of the different needling sensations at the same acupoint are relatively stable at the different times of EA.
基金Supported by Shanghai Science and Technology Ministry Phosphor Project (No.05QMX1402)
文摘Combining two non-contact testing instruments of a three-dimensional body measure system and an infrared camera, the entrapped air gap under clothing and the clothing surface temperature distribution were measured without interfering the air gap state. It was discussed the effect of different air gap size on subjective clothing sensation. At the same time, taken the subjective sensations of moisture, adhesiveness and mugginess from the lower back as example, the relationship among the subjective evaluation, the air gap size and the clothing surface temperature were analyzed.
文摘The term phantom sensations(PS) refers to sensations in a missing body part. They are almost universal in amputees and can be both painful and not painful. Although PS have been frequently described in limb amputees, they can also occur in other clinical conditions and several pathophysiological interpretations have been proposed, with a predominance of theories based on a central origin. Actually, different mechanisms are able to create a phantom sensation. After an amputation, PS are frequently generated by the genesis of ectopic action potentials in the interrupted nerve fibers but the PS generator can also be more proximal. Sometimes PS are not created by the stimulation of somatosensory fibers with a missing territory, but they can be the result of central sensitization or neuroplastic changes that allow for the convergence of impulses coming from different body parts(referred sensations), one of which is missing. In conclusion, PS can be generated by both neuropathic and non-neuropathic mechanisms developed in the amputated body part or in other parts of the nervous system. Since these mechanisms are not pathognomonic of amputation there are no hidden ghosts to look for in phantom sensations. The only interpretative rule is just to follow the pathophysiological principles.
文摘The goal of this preliminary study was to examine the effect of participants’ sexes on the temporal sequence of dominant sensations elicited by fruit-flavored teas. Twelve healthy young adults were assigned to male (n = 6) and female (n = 6) groups. Both groups were evaluated for four sensations using four fruit-flavored teas with 0.05 M sucrose using the temporal dominance of sensations (TDS) method. Only two sensations, sweetness and fruitiness, were consistently reported in the two groups. The male group first reported fruitiness and then sweetness as the dominant sensation following ingestion of the samples. Conversely, the female group reported these two dominant sensations in the reverse order. Significant dominant durations between the two sensations largely varied among the samples in both groups. These results suggest that there are sex-based differences in the temporal sequence of dominant sensations elicited by fruit-flavored teas as evaluated by the TDS method.
文摘Leakage currents, tiny currents flowing from an everyday-life appliance through the body to the ground, can cause a non-adequate perception （called electrocutaneous sensation, ECS） or even pain and should be avoided. Safety standards for low-frequency range are based on experimental results of current thresholds of electrocutaneous sensations, which however show a wide range between about 50 pA （rms） and 1000 μA （rms）. In order to be able to explain these differences, the perception threshold was measured repeatedly in experiments with test persons under identical experimental setup, but by means of different methods （measuring strategies）, namely： direct adjustment, classical threshold as amperage of 50% perception probability, and confidence rating procedure of signal detection theory. The current is injected using a I cm2 electrode at the highly touch sensitive part of the index fingertip. These investigations show for the first time that the threshold of electrocutaneous sensations is influenced both by adaptation to the non-adequate stimulus and individual, emotional factors. Theretbre, classical methods, on which the majority of the safety investigations are based, cannot be used to determine a leakage current threshold. The confidence rating procedure of the modem signal detection theory yields a value of 179.5 μA （rms） at 50 Hz power supply net frequency as the lower end of the 95% confidence range considering the variance in the investigated group. This value is expected to be free of adaptation influences, and is distinctly lower than the European limits and supports the stricter regulations of Canada and USA.
文摘Spinal cord injury(SCI) often results in permanent dysfunction of locomotion,sensation,and autonomic regulation,imposing a substantial burden on both individuals and society(Anjum et al.,2020).SCI has a complex pathophysiology:an initial primary injury(mechanical trauma,axonal disruption,and hemorrhage) is followed by a progressive secondary injury cascade that involves ischemia,neuronal loss,and inflammation.Given the challenges in achieving regeneration of the injured spinal cord,neuroprotection has been at the forefront of clinical research.
基金Supported by the National Natural Science Foundation of China(No.81973758)China Academy of Chinese Medical Sciences Foundation(Nos.ZZ11-048,ZZ-ZR2017004,and ZZ08010)。
文摘Objective:To investigate the effects of different acupuncture manipulations on Deqi sensations and surface myoelectricity,and explore the correlation between Deqi sensations and needling manipulations.Methods:Forty-five healthy participants accepted twirling,lifting-thrusting,and twirling plus lifting-thrusting manipulanions at right Zusanli(ST 36),respectively.The acupuncturist’s and participants’Deqi sensations were collected by MGH Acupuncture Sensation Scale(MASS).The intensity and occurrence rate of soreness,dull pain,pressure,heaviness,fullness,numbness,sharp pain,warmth,coolness,and throbbing feelings of participants,and tightness,smooth,and tangle feelings of acupuncturist were measured.The correlation between the acupuncturist’s and participant’s Deqi sensations was analyzed.Surface electromyogram(EMG)was recorded before,during and after needling in 30 participants.The integrated EMG(iEMG),mean power frequency(MPF)and media frequency(MF)were analyzed.Result:Both fullness and soreness of participants and tightness of acupuncturist were the most frequently occurred ones.A positive correlation between participants’fullness and acupuncturist’s tightness was observed during the three aforementioned needling manipulations(P<0.05,OR>1).Almost all the needling sensations measured in the present study could be induced by the three needling manipulations.However,strength of Deqi sensations was exhibited as lifting-thrusting>twirling plus lifting-thrusting>twirling according to MASS index.The i EMG values were increased and MPF,MF values were decreased during needling compaired to those before needling,especially during lifting-thrusting(P<0.01).Conclusions:The intensity and occurrence rate of the different Deqi sensations induced by different needling manipulations were basically similar.The fullness and soreness were both the most frequently induced Deqi sensations.The strongest Deqi sensation could be induced by lifting-thrusting manipulation.There is a positive correlation between participants’fullness and acupuncturist’s tightness during the three needling manipulations.The myoelectricity around the acupoint is related to Deqi responses.(Registration No.AMCTR-IOR-20000314).
文摘Implantable cardioverter defibrillators(ICDs)represent an established therapeutic strategy for the prevention of sudden cardiac death and reduction of mortality in high-risk patients,while ICDs with cardiac resynchronization therapy defibrillators improve morbidity,quality of life,and mortality in eligible patients with heart failure who are on optimal medical therapy.However,these devices may adversely affect the patients’psychological status after the delivery of shock therapies or even because of the fear of impending therapy.On the other hand,the potential of effective treatment of malignant arrhythmias may provide a‘safety’sensation in most treated patients without significant impairment in the quality of life during periods of clinical stability.During the past few years,an increasing number of reports have investigated psychological distress,including depression and anxiety status in ICD/cardiac resynchronization therapy defibrillator recipients.However,heterogeneous results have been reported while data on the variation of these psychological indexes over time in implanted patients are quite limited.Several intrinsic and extrinsic factors affect the psychological status of these patients while variations of these disturbances in specific populations are evident.Factors that seem to be associated with a greater risk for depression and anxiety in this setting include female gender,younger age,and device shock therapies.Moreover,depression and anxiety may have an adverse impact on patients’clinical outcomes exacerbating heart failure and increasing the arrhythmic risk.In this brief review article,we provide a concise and critical overview of the current literature on this topic,and we also discuss unresolved and conflicting issues delineating future perspectives.
基金supported by the National Research Foundation of Korea(NRF)Grant funded by the Korea Government(Ministry of Science and ICT)(No.NRF-2022R1A2C2010774)by the GRRC program of Gyeonggi Province(GRRC Sungkyunkwan 2023-B04)by Korea Institute for Advancement of Technology(KIAT)grant funded by the Korea Government(MOTIE)(P0020967,Advanced Training Program for Smart Sensor Engineers).
文摘With the rise of artificial intelligence(AI),neuromorphic sensory systems that emulate the five basic human sensations including tactility,audition,olfaction,gustation,and vision have attracted significant attention.In particular,research on integrating sensors with artificial synapses is being carried out extensively.These studies offer valuable opportunities for making another breakthrough in AI technology,including autonomous systems,real-time monitoring systems,and human-machine interactions.In this review,we introduce promising reports of neuromorphic sensory systems.Specifically,the core sensing material,device architecture,fabrication process,and applications of the proposed systems are presented in detail.Finally,the unsolved challenges and the prospects of neuromorphic sensory systems are discussed.
文摘National Theatre of China Copenhagen Date:February 21-March 2,2025 Venue:National Center for the Performing Arts Copenhagen,a two-act play written by Michael Frayn and first performed in 1998,has won numerous awards,including a Tony Award for Best Play,creating a sensation in Europe and the United States.The play has attracted many audiences with its unique structure,mysterious plot,and engaging narrative.It is a dialogue among three dead souls:German scientist Werner Heisenberg,Danish scientist Neils Bohr,and his wife Margrethe.It pieces together a mystery in modern scientific history,of a real-life meeting that took place in 1941 in Copenhagen,at the height of Nazi power,which affected the development of the atomic bomb.
基金Supported by the National High-Level Hospital Clinical Research Funding(No.2022-PUMCH-A-198).
文摘Dear Editor,Recurrent corneal erosion(RCE)is a common clinical condition characterized by repeated episodes of eye redness,pain,foreign-body sensation,photophobia,and tearing[1].The causes of RCE include trauma,chemical and thermal injuries,previous herpetic keratitis,epithelial basement membrane dystrophy,and systemic conditions like epidermolysis bullosa[2-3].
基金supported by STI2030-Major Projects(2021ZD0200200)the Key Collaborative Research Program of the Alliance of International Science Organizations(ANSO-CR-KP-2022-10)+1 种基金the Natural Science Foundation of China(82151307,82202253,and 31620103905)the Science Frontier Program of the Chinese Academy of Sciences(QYZDJ-SSW-SMC019).
文摘Dear Editor,Transcranial Magnetic Stimulation(TMS)has emerged as a promising therapeutic tool for various neurological and psychiatric conditions[1-3].However,despite its potential benefits,TMS is not without its discomfort issues[4,5],which are mainly related to target location,stimulus intensity,and treatment duration.The discomfort associated with TMS arises from several factors,including the physical sensations experienced during the procedure and potential adverse effects on the scalp and surrounding tissues.
基金Supported by National key Basic Research Development Program of China(973 Program):2012 CB 518506National Key Basic Research Development Program of China:2006 CB 504503+1 种基金General Program of National Natural Science Foundation of China:30973793Ph.D.Programs Foundation of Ministry of Education:20090013110005
文摘Objective With the development of science of acupuncture and moxibustion, people have, in the knowledge of ＂deqi＂, developed from subjective level to the quantitative level, and discovered many factors influencing the ＂deqi＂ of acupuncture. In this report, the relationship between ＂deqi＂ and these factors was explored in terms of different acupuncture methods and quantity and depth of stimulus. Methods Ancient literature about ＂deqi＂, as well as related literature for clinical and basic research on ＂deqi＂ in recent 10 years were systematically collected. Results （1） Cerebral functional imaging technology and the scale of ＂deqi＂ were the most common quantitative indexes for ＂deqi＂ in recent 10 years. （2） There were many factors influencing ＂deqi＂ in acupuncture, which involved personal physiological status, nature of disease, anatomical features under the acupoint, different acupuncture methods, quantity and depth of stimulus, etc. Different acupuncture methods, quantity and depth of stimulus would bring different influences on and mechanisms of ＂deqi＂. Conclusion （1） ＂Deqi＂ is not equal to needling sensation; （2） recessive needling sensation should be re-recognized; （3） the sensation of doctor should be paid attention; （4） The meaning of ＂deqi＂ should be re-defined and re-understood.
基金The Major Project of the National Natural Science Foundation of China(No.50838003)the National Key Technology R&D Program of China during the 11th Five-Year Plan Period(No.2006BAJ02A06)
文摘In order to find out how the climatic characteristics affect people＇s adaptability to thermal environments,experimental studies in a climate chamber are conducted on the effects of transition seasons（from spring to summer）and the occupants＇ native areas on indoor thermal sensations.Results reveal that people＇s tolerances to cool and warm indoor environments are different in the transition season.When the outdoor temperature is higher,the occupants have a weaker tolerance to a cool indoor environment,but a stronger tolerance to a warm indoor environment.Besides,it is found that the occupants＇ thermal sensations depend on both the climatic characteristics of the season and their native areas.The people from southern China present a greater tolerance to both warm and cool indoor environments than those from northern China.The reason can be explained according to the occupants＇ adaptability to the climatic characteristics and the indoor thermal environments of their native areas in different climate zones.
基金supported by the National Key Research and Development Program of China(Grant No.2018YFB1307201)the National Natural Science Foundation of China(Grant Nos.51875120,91948302,U1813209).
文摘Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of amputees.Current studies focus on tactile feedback,while the lack of appropriate multisensory feedback,especially proprioception feedback,limits the grasping quality.Additionally,a typical non-invasive stimulation scheme for sensation feedback uses stimulation on the stationary site of the skin continuously,which can lead to fatigue and adaptation of sensation,further reduces the feedback consistency,and increases the cognitive burden for the subject.Considering the sensitivity and modality matching of sensation,this study presented a multimodal sensations feedback scheme based on hybrid static-dynamic sensation elicited by multisite Transcutaneous Electrical Nerve Stimulation(TENS)to deliver grasping force and joint position feedback.In the proposed scheme,stimulation of single electrode produced only in-loco tactile sensation under the electrode,and the sensation intensity was adjusted according to grasping force;sequential activation of multi-electrodes produced an illusion dynamic sensation of a stimulus moving,and the velocity and direction of movement were adjusted according to finger joint position.Psychometric test results demonstrated the identifiability of stimulus in the proposed scheme.Further,prosthetic hand closed-loop grasping tasks evaluate the effectiveness of the proposed feedback scheme.The results showed that the proposed feedback scheme could substantially improve the grasping accuracy and efficiency.In addition,the study outcomes also demonstrated the benefit of artificial proprioception feedback in grasping rapidity and security.
