The proportionate recursive least squares(PRLS)algorithm has shown faster convergence and better performance than both proportionate updating(PU)mechanism based least mean squares(LMS)algorithms and RLS algorithms wit...The proportionate recursive least squares(PRLS)algorithm has shown faster convergence and better performance than both proportionate updating(PU)mechanism based least mean squares(LMS)algorithms and RLS algorithms with a sparse regularization term.In this paper,we propose a variable forgetting factor(VFF)PRLS algorithm with a sparse penalty,e.g.,l_(1)-norm,for sparse identification.To reduce the computation complexity of the proposed algorithm,a fast implementation method based on dichotomous coordinate descent(DCD)algorithm is also derived.Simulation results indicate superior performance of the proposed algorithm.展开更多
BACKGROUND Accurate data on the prognosis of bone metastases are necessary for appropriate treatment.Immune checkpoint inhibitors(ICIs)are widely used in the treatment of gene mutation-negative non-small cell lung can...BACKGROUND Accurate data on the prognosis of bone metastases are necessary for appropriate treatment.Immune checkpoint inhibitors(ICIs)are widely used in the treatment of gene mutation-negative non-small cell lung cancer(GMN-NSCLC).AIM To investigate the prognostic factors in patients with bone metastases from GMNNSCLC following ICI use.METHODS This retrospective cohort study included 45 patients with GMN-NSCLC who were treated for bone metastases from 2017 to 2022 and received chemotherapy after diagnosis.Using Kaplan–Meier curves and Cox proportional hazards models,we evaluated the association between overall survival(OS)and clinical parameters,including serum biochemical concentrations and blood cell count.RESULTS Univariate analysis showed that Eastern Cooperative Oncology Group performance status≤1 and the use of ICIs and bone-modifying agents after bone metastasis diagnosis were significantly associated with a favorable OS.Multivariate analysis revealed that ICI use after bone metastasis diagnosis was signicantly associated with a favorable OS.CONCLUSION ICI use after bone metastasis diagnosis may be a favorable prognostic factor in patients with bone metastases of GMN-NSCLC.Consideration of ICI treatment for bone metastasis and GMN-NSCLC is warranted to establish a more accurate predictive nomogram for patients with bone metastasis.展开更多
A multi-qubit pure quantum state is called separable when it can be factored as the tensor product of 1-qubit pure quantum states.Factorizing a general multi-qubit pure quantum state into the tensor product of its fac...A multi-qubit pure quantum state is called separable when it can be factored as the tensor product of 1-qubit pure quantum states.Factorizing a general multi-qubit pure quantum state into the tensor product of its factors(pure states containing a smaller number of qubits)can be a challenging task,especially for highly entangled states.A new criterion based on the proportionality of the rows of certain associated matrices for the existence of certain factorization and a factorization algorithm that follows from this criterion for systematically extracting all the factors is developed in this paper.3-qubit pure states play a crucial role in quantum computing and quantum information processing.For various applications,the well-known 3-qubit GHZ state which contains two nonzero terms,and the 3-qubit W state which contains three nonzero terms,have been studied extensively.Using the new factorization algorithm developed here we perform a complete analysis vis-à-vis entanglement of 3-qubit states that contain exactly two nonzero terms and exactly three nonzero terms.展开更多
Introduction Long-term use of benzodiazepines(BZD)triggers health problems.Although Spain leads European use of BZD,the number of long-term users(LTUs)remains unknown.Objective The aim of the study is to estimate the ...Introduction Long-term use of benzodiazepines(BZD)triggers health problems.Although Spain leads European use of BZD,the number of long-term users(LTUs)remains unknown.Objective The aim of the study is to estimate the proportion of primary care(PC)patients who initiate a BDZ prescription that subsequently become LTU and to identify its associated factors.Design Retrospective real-world data cohort.Setting and participant It included the population over 15 years with a new prescription of BZD in PC in Catalonia.Users were considered LTU if they had been dispensed at least three prescriptions within 3 months.Sociodemographic characteristics of patients and prescribers,pathologies,previous BZD use,number and type of visits,and prescription quality standard were considered.We estimated the proportion of LTU among patients with a new prescription,stratified by age and sex,and estimated risk factors by multivariate generalised linear models.Result 100638 users with a new BZD prescription were included.27.1%were LTU at 3 months and 14.5%at 6 months.LTU increases with age and is higher in women.Predictors of LTU are Spanish nationality,living in rural areas,having a mental illness,having used BZD,having virtual visits or not meeting pharmacy-therapeutic quality standards.Conclusion The number of patients who develop LTU is high,especially in the elderly.Exploring the causes of this phenomenon could contribute to the development of future interventions.展开更多
基金supported by National Key Research and Development Program of China(2020YFB0505803)National Key Research and Development Program of China(2016YFB0501700)。
文摘The proportionate recursive least squares(PRLS)algorithm has shown faster convergence and better performance than both proportionate updating(PU)mechanism based least mean squares(LMS)algorithms and RLS algorithms with a sparse regularization term.In this paper,we propose a variable forgetting factor(VFF)PRLS algorithm with a sparse penalty,e.g.,l_(1)-norm,for sparse identification.To reduce the computation complexity of the proposed algorithm,a fast implementation method based on dichotomous coordinate descent(DCD)algorithm is also derived.Simulation results indicate superior performance of the proposed algorithm.
文摘BACKGROUND Accurate data on the prognosis of bone metastases are necessary for appropriate treatment.Immune checkpoint inhibitors(ICIs)are widely used in the treatment of gene mutation-negative non-small cell lung cancer(GMN-NSCLC).AIM To investigate the prognostic factors in patients with bone metastases from GMNNSCLC following ICI use.METHODS This retrospective cohort study included 45 patients with GMN-NSCLC who were treated for bone metastases from 2017 to 2022 and received chemotherapy after diagnosis.Using Kaplan–Meier curves and Cox proportional hazards models,we evaluated the association between overall survival(OS)and clinical parameters,including serum biochemical concentrations and blood cell count.RESULTS Univariate analysis showed that Eastern Cooperative Oncology Group performance status≤1 and the use of ICIs and bone-modifying agents after bone metastasis diagnosis were significantly associated with a favorable OS.Multivariate analysis revealed that ICI use after bone metastasis diagnosis was signicantly associated with a favorable OS.CONCLUSION ICI use after bone metastasis diagnosis may be a favorable prognostic factor in patients with bone metastases of GMN-NSCLC.Consideration of ICI treatment for bone metastasis and GMN-NSCLC is warranted to establish a more accurate predictive nomogram for patients with bone metastasis.
文摘A multi-qubit pure quantum state is called separable when it can be factored as the tensor product of 1-qubit pure quantum states.Factorizing a general multi-qubit pure quantum state into the tensor product of its factors(pure states containing a smaller number of qubits)can be a challenging task,especially for highly entangled states.A new criterion based on the proportionality of the rows of certain associated matrices for the existence of certain factorization and a factorization algorithm that follows from this criterion for systematically extracting all the factors is developed in this paper.3-qubit pure states play a crucial role in quantum computing and quantum information processing.For various applications,the well-known 3-qubit GHZ state which contains two nonzero terms,and the 3-qubit W state which contains three nonzero terms,have been studied extensively.Using the new factorization algorithm developed here we perform a complete analysis vis-à-vis entanglement of 3-qubit states that contain exactly two nonzero terms and exactly three nonzero terms.
基金supported by the CIBERESP Network Biomedical Research Center for Epidemiology and Public Health(ESP22PI08)Intramural Call for Research Projects 2022The funding entity was not involved in the design or development of the study.IA-L has a Miguel Servet contract(CP22/00029)funded by the Carlos III Health Institute.
文摘Introduction Long-term use of benzodiazepines(BZD)triggers health problems.Although Spain leads European use of BZD,the number of long-term users(LTUs)remains unknown.Objective The aim of the study is to estimate the proportion of primary care(PC)patients who initiate a BDZ prescription that subsequently become LTU and to identify its associated factors.Design Retrospective real-world data cohort.Setting and participant It included the population over 15 years with a new prescription of BZD in PC in Catalonia.Users were considered LTU if they had been dispensed at least three prescriptions within 3 months.Sociodemographic characteristics of patients and prescribers,pathologies,previous BZD use,number and type of visits,and prescription quality standard were considered.We estimated the proportion of LTU among patients with a new prescription,stratified by age and sex,and estimated risk factors by multivariate generalised linear models.Result 100638 users with a new BZD prescription were included.27.1%were LTU at 3 months and 14.5%at 6 months.LTU increases with age and is higher in women.Predictors of LTU are Spanish nationality,living in rural areas,having a mental illness,having used BZD,having virtual visits or not meeting pharmacy-therapeutic quality standards.Conclusion The number of patients who develop LTU is high,especially in the elderly.Exploring the causes of this phenomenon could contribute to the development of future interventions.
