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改进Deep Q Networks的交通信号均衡调度算法
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作者 贺道坤 《机械设计与制造》 北大核心 2025年第4期135-140,共6页
为进一步缓解城市道路高峰时段十字路口的交通拥堵现象,实现路口各道路车流均衡通过,基于改进Deep Q Networks提出了一种的交通信号均衡调度算法。提取十字路口与交通信号调度最相关的特征,分别建立单向十字路口交通信号模型和线性双向... 为进一步缓解城市道路高峰时段十字路口的交通拥堵现象,实现路口各道路车流均衡通过,基于改进Deep Q Networks提出了一种的交通信号均衡调度算法。提取十字路口与交通信号调度最相关的特征,分别建立单向十字路口交通信号模型和线性双向十字路口交通信号模型,并基于此构建交通信号调度优化模型;针对Deep Q Networks算法在交通信号调度问题应用中所存在的收敛性、过估计等不足,对Deep Q Networks进行竞争网络改进、双网络改进以及梯度更新策略改进,提出相适应的均衡调度算法。通过与经典Deep Q Networks仿真比对,验证论文算法对交通信号调度问题的适用性和优越性。基于城市道路数据,分别针对两种场景进行仿真计算,仿真结果表明该算法能够有效缩减十字路口车辆排队长度,均衡各路口车流通行量,缓解高峰出行方向的道路拥堵现象,有利于十字路口交通信号调度效益的提升。 展开更多
关键词 交通信号调度 十字路口 Deep Q networks 深度强化学习 智能交通
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LATITUDES Network:提升证据合成稳健性的效度(偏倚风险)评价工具库
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作者 廖明雨 熊益权 +7 位作者 赵芃 郭金 陈靖文 刘春容 贾玉龙 任燕 孙鑫 谭婧 《中国循证医学杂志》 北大核心 2025年第5期614-620,共7页
证据合成是对现有研究证据进行系统收集、分析和整合的过程,其结果依赖于纳入原始研究的质量,而效度评价(validity assessment,又称偏倚风险评价)则是评估这些原始研究质量的重要手段。现有效度评价工具种类繁多,但部分工具缺乏严格的... 证据合成是对现有研究证据进行系统收集、分析和整合的过程,其结果依赖于纳入原始研究的质量,而效度评价(validity assessment,又称偏倚风险评价)则是评估这些原始研究质量的重要手段。现有效度评价工具种类繁多,但部分工具缺乏严格的开发过程和评估,证据合成过程中应用不恰当的效度评价工具开展文献质量评价,可能会影响研究结论的准确性,误导临床实践。为解决这一困境,2023年9月英国Bristol大学学者牵头成立了效度评价工具一站式资源站LATITUDES Network。该网站致力于收集、整理和推广研究效度评价工具,以促进原始研究效度评价的准确性,提升证据合成的稳健性和可靠性。本文对LATITUDES Network成立背景、收录的效度评价工具,以及评价工具使用的培训资源等内容进行了详细介绍,以期为国内学者更多地了解LATITUDES Network,更好地运用恰当的效度评价工具开展文献质量评价,以及为开发效度评价工具等提供参考。 展开更多
关键词 效度评价 偏倚风险 证据合成 LATITUDES network
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Application of virtual reality technology improves the functionality of brain networks in individuals experiencing pain 被引量:3
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作者 Takahiko Nagamine 《World Journal of Clinical Cases》 SCIE 2025年第3期66-68,共3页
Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the u... Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field. 展开更多
关键词 Virtual reality PAIN ANXIETY Salience network Default mode network
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Robustness Optimization Algorithm with Multi-Granularity Integration for Scale-Free Networks Against Malicious Attacks 被引量:1
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作者 ZHANG Yiheng LI Jinhai 《昆明理工大学学报(自然科学版)》 北大核心 2025年第1期54-71,共18页
Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently... Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently,enhancing the robustness of scale-free networks has become a pressing issue.To address this problem,this paper proposes a Multi-Granularity Integration Algorithm(MGIA),which aims to improve the robustness of scale-free networks while keeping the initial degree of each node unchanged,ensuring network connectivity and avoiding the generation of multiple edges.The algorithm generates a multi-granularity structure from the initial network to be optimized,then uses different optimization strategies to optimize the networks at various granular layers in this structure,and finally realizes the information exchange between different granular layers,thereby further enhancing the optimization effect.We propose new network refresh,crossover,and mutation operators to ensure that the optimized network satisfies the given constraints.Meanwhile,we propose new network similarity and network dissimilarity evaluation metrics to improve the effectiveness of the optimization operators in the algorithm.In the experiments,the MGIA enhances the robustness of the scale-free network by 67.6%.This improvement is approximately 17.2%higher than the optimization effects achieved by eight currently existing complex network robustness optimization algorithms. 展开更多
关键词 complex network model MULTI-GRANULARITY scale-free networks ROBUSTNESS algorithm integration
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Offload Strategy for Edge Computing in Satellite Networks Based on Software Defined Network 被引量:1
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作者 Zhiguo Liu Yuqing Gui +1 位作者 Lin Wang Yingru Jiang 《Computers, Materials & Continua》 SCIE EI 2025年第1期863-879,共17页
Satellite edge computing has garnered significant attention from researchers;however,processing a large volume of tasks within multi-node satellite networks still poses considerable challenges.The sharp increase in us... Satellite edge computing has garnered significant attention from researchers;however,processing a large volume of tasks within multi-node satellite networks still poses considerable challenges.The sharp increase in user demand for latency-sensitive tasks has inevitably led to offloading bottlenecks and insufficient computational capacity on individual satellite edge servers,making it necessary to implement effective task offloading scheduling to enhance user experience.In this paper,we propose a priority-based task scheduling strategy based on a Software-Defined Network(SDN)framework for satellite-terrestrial integrated networks,which clarifies the execution order of tasks based on their priority.Subsequently,we apply a Dueling-Double Deep Q-Network(DDQN)algorithm enhanced with prioritized experience replay to derive a computation offloading strategy,improving the experience replay mechanism within the Dueling-DDQN framework.Next,we utilize the Deep Deterministic Policy Gradient(DDPG)algorithm to determine the optimal resource allocation strategy to reduce the processing latency of sub-tasks.Simulation results demonstrate that the proposed d3-DDPG algorithm outperforms other approaches,effectively reducing task processing latency and thus improving user experience and system efficiency. 展开更多
关键词 Satellite network edge computing task scheduling computing offloading
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A Novel Self-Supervised Learning Network for Binocular Disparity Estimation 被引量:1
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作者 Jiawei Tian Yu Zhou +5 位作者 Xiaobing Chen Salman A.AlQahtani Hongrong Chen Bo Yang Siyu Lu Wenfeng Zheng 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期209-229,共21页
Two-dimensional endoscopic images are susceptible to interferences such as specular reflections and monotonous texture illumination,hindering accurate three-dimensional lesion reconstruction by surgical robots.This st... Two-dimensional endoscopic images are susceptible to interferences such as specular reflections and monotonous texture illumination,hindering accurate three-dimensional lesion reconstruction by surgical robots.This study proposes a novel end-to-end disparity estimation model to address these challenges.Our approach combines a Pseudo-Siamese neural network architecture with pyramid dilated convolutions,integrating multi-scale image information to enhance robustness against lighting interferences.This study introduces a Pseudo-Siamese structure-based disparity regression model that simplifies left-right image comparison,improving accuracy and efficiency.The model was evaluated using a dataset of stereo endoscopic videos captured by the Da Vinci surgical robot,comprising simulated silicone heart sequences and real heart video data.Experimental results demonstrate significant improvement in the network’s resistance to lighting interference without substantially increasing parameters.Moreover,the model exhibited faster convergence during training,contributing to overall performance enhancement.This study advances endoscopic image processing accuracy and has potential implications for surgical robot applications in complex environments. 展开更多
关键词 Parallax estimation parallax regression model self-supervised learning Pseudo-Siamese neural network pyramid dilated convolution binocular disparity estimation
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DEEP NEURAL NETWORKS COMBINING MULTI-TASK LEARNING FOR SOLVING DELAY INTEGRO-DIFFERENTIAL EQUATIONS 被引量:1
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作者 WANG Chen-yao SHI Feng 《数学杂志》 2025年第1期13-38,共26页
Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay di... Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay differential equations(DDEs)and delay integrodifferential equations(DIDEs)with constant delays,primarily due to their low regularity at delayinduced breaking points.In this paper,a DNN method that combines multi-task learning(MTL)which is proposed to solve both the forward and inverse problems of DIDEs.The core idea of this approach is to divide the original equation into multiple tasks based on the delay,using auxiliary outputs to represent the integral terms,followed by the use of MTL to seamlessly incorporate the properties at the breaking points into the loss function.Furthermore,given the increased training dificulty associated with multiple tasks and outputs,we employ a sequential training scheme to reduce training complexity and provide reference solutions for subsequent tasks.This approach significantly enhances the approximation accuracy of solving DIDEs with DNNs,as demonstrated by comparisons with traditional DNN methods.We validate the effectiveness of this method through several numerical experiments,test various parameter sharing structures in MTL and compare the testing results of these structures.Finally,this method is implemented to solve the inverse problem of nonlinear DIDE and the results show that the unknown parameters of DIDE can be discovered with sparse or noisy data. 展开更多
关键词 Delay integro-differential equation Multi-task learning parameter sharing structure deep neural network sequential training scheme
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Multi-Stage-Based Siamese Neural Network for Seal Image Recognition
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作者 Jianfeng Lu Xiangye Huang +3 位作者 Caijin Li Renlin Xin Shanqing Zhang Mahmoud Emam 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期405-423,共19页
Seal authentication is an important task for verifying the authenticity of stamped seals used in various domains to protect legal documents from tampering and counterfeiting.Stamped seal inspection is commonly audited... Seal authentication is an important task for verifying the authenticity of stamped seals used in various domains to protect legal documents from tampering and counterfeiting.Stamped seal inspection is commonly audited manually to ensure document authenticity.However,manual assessment of seal images is tedious and laborintensive due to human errors,inconsistent placement,and completeness of the seal.Traditional image recognition systems are inadequate enough to identify seal types accurately,necessitating a neural network-based method for seal image recognition.However,neural network-based classification algorithms,such as Residual Networks(ResNet)andVisualGeometryGroup with 16 layers(VGG16)yield suboptimal recognition rates on stamp datasets.Additionally,the fixed training data categories make handling new categories to be a challenging task.This paper proposes amulti-stage seal recognition algorithmbased on Siamese network to overcome these limitations.Firstly,the seal image is pre-processed by applying an image rotation correction module based on Histogram of Oriented Gradients(HOG).Secondly,the similarity between input seal image pairs is measured by utilizing a similarity comparison module based on the Siamese network.Finally,we compare the results with the pre-stored standard seal template images in the database to obtain the seal type.To evaluate the performance of the proposed method,we further create a new seal image dataset that contains two subsets with 210,000 valid labeled pairs in total.The proposed work has a practical significance in industries where automatic seal authentication is essential as in legal,financial,and governmental sectors,where automatic seal recognition can enhance document security and streamline validation processes.Furthermore,the experimental results show that the proposed multi-stage method for seal image recognition outperforms state-of-the-art methods on the two established datasets. 展开更多
关键词 Seal recognition seal authentication document tampering siamese network spatial transformer network similarity comparison network
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Enhanced electrode-level diagnostics for lithium-ion battery degradation using physics-informed neural networks 被引量:1
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作者 Rui Xiong Yinghao He +2 位作者 Yue Sun Yanbo Jia Weixiang Shen 《Journal of Energy Chemistry》 2025年第5期618-627,共10页
For the diagnostics and health management of lithium-ion batteries,numerous models have been developed to understand their degradation characteristics.These models typically fall into two categories:data-driven models... For the diagnostics and health management of lithium-ion batteries,numerous models have been developed to understand their degradation characteristics.These models typically fall into two categories:data-driven models and physical models,each offering unique advantages but also facing limitations.Physics-informed neural networks(PINNs)provide a robust framework to integrate data-driven models with physical principles,ensuring consistency with underlying physics while enabling generalization across diverse operational conditions.This study introduces a PINN-based approach to reconstruct open circuit voltage(OCV)curves and estimate key ageing parameters at both the cell and electrode levels.These parameters include available capacity,electrode capacities,and lithium inventory capacity.The proposed method integrates OCV reconstruction models as functional components into convolutional neural networks(CNNs)and is validated using a public dataset.The results reveal that the estimated ageing parameters closely align with those obtained through offline OCV tests,with errors in reconstructed OCV curves remaining within 15 mV.This demonstrates the ability of the method to deliver fast and accurate degradation diagnostics at the electrode level,advancing the potential for precise and efficient battery health management. 展开更多
关键词 Lithium-ion batteries Electrode level Ageing diagnosis Physics-informed neural network Convolutional neural networks
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TMC-GCN: Encrypted Traffic Mapping Classification Method Based on Graph Convolutional Networks 被引量:1
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作者 Baoquan Liu Xi Chen +2 位作者 Qingjun Yuan Degang Li Chunxiang Gu 《Computers, Materials & Continua》 2025年第2期3179-3201,共23页
With the emphasis on user privacy and communication security, encrypted traffic has increased dramatically, which brings great challenges to traffic classification. The classification method of encrypted traffic based... With the emphasis on user privacy and communication security, encrypted traffic has increased dramatically, which brings great challenges to traffic classification. The classification method of encrypted traffic based on GNN can deal with encrypted traffic well. However, existing GNN-based approaches ignore the relationship between client or server packets. In this paper, we design a network traffic topology based on GCN, called Flow Mapping Graph (FMG). FMG establishes sequential edges between vertexes by the arrival order of packets and establishes jump-order edges between vertexes by connecting packets in different bursts with the same direction. It not only reflects the time characteristics of the packet but also strengthens the relationship between the client or server packets. According to FMG, a Traffic Mapping Classification model (TMC-GCN) is designed, which can automatically capture and learn the characteristics and structure information of the top vertex in FMG. The TMC-GCN model is used to classify the encrypted traffic. The encryption stream classification problem is transformed into a graph classification problem, which can effectively deal with data from different data sources and application scenarios. By comparing the performance of TMC-GCN with other classical models in four public datasets, including CICIOT2023, ISCXVPN2016, CICAAGM2017, and GraphDapp, the effectiveness of the FMG algorithm is verified. The experimental results show that the accuracy rate of the TMC-GCN model is 96.13%, the recall rate is 95.04%, and the F1 rate is 94.54%. 展开更多
关键词 Encrypted traffic classification deep learning graph neural networks multi-layer perceptron graph convolutional networks
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Traffic safety helmet wear detection based on improved YOLOv5 network 被引量:1
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作者 GUI Dongdong SUN Bo 《Optoelectronics Letters》 2025年第1期35-42,共8页
Aiming at the problem that the current traffic safety helmet detection model can't balance the accuracy of detection with the size of the model and the poor generalization of the model,a method based on improving ... Aiming at the problem that the current traffic safety helmet detection model can't balance the accuracy of detection with the size of the model and the poor generalization of the model,a method based on improving you only look once version 5(YOLOv5) is proposed.By incorporating the lightweight Ghost Net module into the YOLOv5 backbone network,we effectively reduce the model size.The addition of the receptive fields block(RFB) module enhances feature extraction and improves the feature acquisition capability of the lightweight model.Subsequently,the high-performance lightweight convolution,GSConv,is integrated into the neck structure for further model size compression.Moreover,the baseline model's loss function is substituted with efficient insertion over union(EIoU),accelerating network convergence and enhancing detection precision.Experimental results corroborate the effectiveness of this improved algorithm in real-world traffic scenarios. 展开更多
关键词 network UNION BACKBONE
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Atmospheric scattering model and dark channel prior constraint network for environmental monitoring under hazy conditions 被引量:2
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作者 Lintao Han Hengyi Lv +3 位作者 Chengshan Han Yuchen Zhao Qing Han Hailong Liu 《Journal of Environmental Sciences》 2025年第6期203-218,共16页
Environmentalmonitoring systems based on remote sensing technology have a wider monitoringrange and longer timeliness, which makes them widely used in the detection andmanagement of pollution sources. However, haze we... Environmentalmonitoring systems based on remote sensing technology have a wider monitoringrange and longer timeliness, which makes them widely used in the detection andmanagement of pollution sources. However, haze weather conditions degrade image qualityand reduce the precision of environmental monitoring systems. To address this problem,this research proposes a remote sensing image dehazingmethod based on the atmosphericscattering model and a dark channel prior constrained network. The method consists ofa dehazing network, a dark channel information injection network (DCIIN), and a transmissionmap network. Within the dehazing network, the branch fusion module optimizesfeature weights to enhance the dehazing effect. By leveraging dark channel information,the DCIIN enables high-quality estimation of the atmospheric veil. To ensure the outputof the deep learning model aligns with physical laws, we reconstruct the haze image usingthe prediction results from the three networks. Subsequently, we apply the traditionalloss function and dark channel loss function between the reconstructed haze image and theoriginal haze image. This approach enhances interpretability and reliabilitywhile maintainingadherence to physical principles. Furthermore, the network is trained on a synthesizednon-homogeneous haze remote sensing dataset using dark channel information from cloudmaps. The experimental results show that the proposed network can achieve better imagedehazing on both synthetic and real remote sensing images with non-homogeneous hazedistribution. This research provides a new idea for solving the problem of decreased accuracyof environmental monitoring systems under haze weather conditions and has strongpracticability. 展开更多
关键词 Remote sensing Image dehazing Environmental monitoring Neural network INTERPRETABILITY
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Dynamic Multi-Graph Spatio-Temporal Graph Traffic Flow Prediction in Bangkok:An Application of a Continuous Convolutional Neural Network
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作者 Pongsakon Promsawat Weerapan Sae-dan +2 位作者 Marisa Kaewsuwan Weerawat Sudsutad Aphirak Aphithana 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期579-607,共29页
The ability to accurately predict urban traffic flows is crucial for optimising city operations.Consequently,various methods for forecasting urban traffic have been developed,focusing on analysing historical data to u... The ability to accurately predict urban traffic flows is crucial for optimising city operations.Consequently,various methods for forecasting urban traffic have been developed,focusing on analysing historical data to understand complex mobility patterns.Deep learning techniques,such as graph neural networks(GNNs),are popular for their ability to capture spatio-temporal dependencies.However,these models often become overly complex due to the large number of hyper-parameters involved.In this study,we introduce Dynamic Multi-Graph Spatial-Temporal Graph Neural Ordinary Differential Equation Networks(DMST-GNODE),a framework based on ordinary differential equations(ODEs)that autonomously discovers effective spatial-temporal graph neural network(STGNN)architectures for traffic prediction tasks.The comparative analysis of DMST-GNODE and baseline models indicates that DMST-GNODE model demonstrates superior performance across multiple datasets,consistently achieving the lowest Root Mean Square Error(RMSE)and Mean Absolute Error(MAE)values,alongside the highest accuracy.On the BKK(Bangkok)dataset,it outperformed other models with an RMSE of 3.3165 and an accuracy of 0.9367 for a 20-min interval,maintaining this trend across 40 and 60 min.Similarly,on the PeMS08 dataset,DMST-GNODE achieved the best performance with an RMSE of 19.4863 and an accuracy of 0.9377 at 20 min,demonstrating its effectiveness over longer periods.The Los_Loop dataset results further emphasise this model’s advantage,with an RMSE of 3.3422 and an accuracy of 0.7643 at 20 min,consistently maintaining superiority across all time intervals.These numerical highlights indicate that DMST-GNODE not only outperforms baseline models but also achieves higher accuracy and lower errors across different time intervals and datasets. 展开更多
关键词 Graph neural networks convolutional neural network deep learning dynamic multi-graph SPATIO-TEMPORAL
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DIGNN-A:Real-Time Network Intrusion Detection with Integrated Neural Networks Based on Dynamic Graph
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作者 Jizhao Liu Minghao Guo 《Computers, Materials & Continua》 SCIE EI 2025年第1期817-842,共26页
The increasing popularity of the Internet and the widespread use of information technology have led to a rise in the number and sophistication of network attacks and security threats.Intrusion detection systems are cr... The increasing popularity of the Internet and the widespread use of information technology have led to a rise in the number and sophistication of network attacks and security threats.Intrusion detection systems are crucial to network security,playing a pivotal role in safeguarding networks from potential threats.However,in the context of an evolving landscape of sophisticated and elusive attacks,existing intrusion detection methodologies often overlook critical aspects such as changes in network topology over time and interactions between hosts.To address these issues,this paper proposes a real-time network intrusion detection method based on graph neural networks.The proposedmethod leverages the advantages of graph neural networks and employs a straightforward graph construction method to represent network traffic as dynamic graph-structured data.Additionally,a graph convolution operation with a multi-head attention mechanism is utilized to enhance the model’s ability to capture the intricate relationships within the graph structure comprehensively.Furthermore,it uses an integrated graph neural network to address dynamic graphs’structural and topological changes at different time points and the challenges of edge embedding in intrusion detection data.The edge classification problem is effectively transformed into node classification by employing a line graph data representation,which facilitates fine-grained intrusion detection tasks on dynamic graph node feature representations.The efficacy of the proposed method is evaluated using two commonly used intrusion detection datasets,UNSW-NB15 and NF-ToN-IoT-v2,and results are compared with previous studies in this field.The experimental results demonstrate that our proposed method achieves 99.3%and 99.96%accuracy on the two datasets,respectively,and outperforms the benchmark model in several evaluation metrics. 展开更多
关键词 Intrusion detection graph neural networks attention mechanisms line graphs dynamic graph neural networks
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Secure Channel Estimation Using Norm Estimation Model for 5G Next Generation Wireless Networks
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作者 Khalil Ullah Song Jian +4 位作者 Muhammad Naeem Ul Hassan Suliman Khan Mohammad Babar Arshad Ahmad Shafiq Ahmad 《Computers, Materials & Continua》 SCIE EI 2025年第1期1151-1169,共19页
The emergence of next generation networks(NextG),including 5G and beyond,is reshaping the technological landscape of cellular and mobile networks.These networks are sufficiently scaled to interconnect billions of user... The emergence of next generation networks(NextG),including 5G and beyond,is reshaping the technological landscape of cellular and mobile networks.These networks are sufficiently scaled to interconnect billions of users and devices.Researchers in academia and industry are focusing on technological advancements to achieve highspeed transmission,cell planning,and latency reduction to facilitate emerging applications such as virtual reality,the metaverse,smart cities,smart health,and autonomous vehicles.NextG continuously improves its network functionality to support these applications.Multiple input multiple output(MIMO)technology offers spectral efficiency,dependability,and overall performance in conjunctionwithNextG.This article proposes a secure channel estimation technique in MIMO topology using a norm-estimation model to provide comprehensive insights into protecting NextG network components against adversarial attacks.The technique aims to create long-lasting and secure NextG networks using this extended approach.The viability of MIMO applications and modern AI-driven methodologies to combat cybersecurity threats are explored in this research.Moreover,the proposed model demonstrates high performance in terms of reliability and accuracy,with a 20%reduction in the MalOut-RealOut-Diff metric compared to existing state-of-the-art techniques. 展开更多
关键词 Next generation networks massive mimo communication network artificial intelligence 5G adversarial attacks channel estimation information security
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Metabolomics, network pharmacology, and microbiome analyses uncover the mechanisms of the Chinese herbal formula for the improvement of meat quality in spent hens 被引量:2
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作者 Zhihua Li Abul Kalam Azad +6 位作者 Chengwen Meng Xiangfeng Kong Jue Gui Wenchao Lin Yadong Cui Wei Lan Qinghua He 《Journal of Animal Science and Biotechnology》 2025年第2期948-964,共17页
Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi... Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi-cine for a long time to prevent diseases and as nutrient supplements to improve the product quality.This experi-ment explored the effects of adding 1.0%Chinese herbal formula(CHF,including 0.30%Leonurus japonicus Houtt.,0.20%Salvia miltiorrhiza Bge.,0.25%Ligustrum lucidum Ait.,and 0.25%Taraxacum mongolicum Hand.-Mazz.)for 120 d to the spent hens’diet through metabolomics,network pharmacology,and microbiome strategies.Results The results indicated that CHF supplementation improved the meat quality by reducing drip loss(P<0.05),b*value(P=0.058),and shear force(P=0.099)and increasing cooked meat percentage(P=0.054)and dry matter(P<0.05)of breast muscle.The addition of CHF improved the nutritional value of breast muscle by increasing(P<0.05)the content of C18:2n-6,n-6/n-3 polyunsaturated fatty acids(PUFA),total PUFA,PUFA-to-saturated fatty acids(SFA)ratio,and hypocholesterolemic-to-hypercholesterolemic ratio,and tending to increase serine content(P=0.069).The targeted metabolomics analysis revealed that the biosynthesis of SFA,linoleic acid metabolism,fatty acid degradation,fatty acid elongation,and fatty acid biosynthesis pathways were enriched by CHF supplementation.Furthermore,the network pharmacology analysis indicated that CHF was closely associated with oxidative stress and lipid metabo-lism.The CHF supplementation increased the glutathione peroxidase level(P<0.05)and upregulated gene expres-sion related to the Nrf2 pathway(including HO-1,P<0.05;Nrf2,P=0.098;CAT,P=0.060;GPX1,P=0.063;and SOD2,P=0.052)and lipid metabolism(including PPARγ,P<0.05;SREBP1,P=0.059;and CPT1A,P=0.058).Additionally,CHF supplementation increased Firmicutes and decreased Bacteroidetes,Spirochaetes,and Synergistetes abundances(P<0.05),which may contribute to better meat quality.Conclusions Our results suggest that CHF supplementation improved the quality and nutritional value of meat,which will provide a theoretical basis for the utilization of CHF as a feed additive in spent hens’diets. 展开更多
关键词 Cecal microbiota Chinese herbal formula Fatty acid Meat quality network pharmacology Spent hens
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Constrained Networked Predictive Control for Nonlinear Systems Using a High-Order Fully Actuated System Approach 被引量:1
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作者 Yi Huang Guo-Ping Liu +1 位作者 Yi Yu Wenshan Hu 《IEEE/CAA Journal of Automatica Sinica》 2025年第2期478-480,共3页
Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectiv... Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectively deal with nonlinearities,constraints,and noises in the system,optimize the performance metric,and present an upper bound on the stable output of the system. 展开更多
关键词 optimal control problem constrained networked predictive control strategy Performance Optimization present upper bound Nonlinear Systems NOISES Constrained networked Predictive Control High Order Fully Actuated Systems
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Network pharmacology:Changes the treatment mode of"one disease-one target"in cancer treatment
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作者 Shuai Liu Yong-Wei Yu 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第1期268-271,共4页
The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine(TCM)treatment of cancer.TCM is a new choice and hot spot in the field of can... The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine(TCM)treatment of cancer.TCM is a new choice and hot spot in the field of cancer treatment.We have also previously published studies on TCM and network pharmacology.In this letter,we summarize the new paradigm of network pharmacology in cancer treatment mechanisms. 展开更多
关键词 network pharmacology CANCER MULTICOMPONENT Multitarget THERAPY
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Enhancing reliability in photonuclear cross-section fitting with Bayesian neural networks 被引量:1
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作者 Qian-Kun Sun Yue Zhang +8 位作者 Zi-Rui Hao Hong-Wei Wang Gong-Tao Fan Hang-Hua Xu Long-Xiang Liu Sheng Jin Yu-Xuan Yang Kai-Jie Chen Zhen-Wei Wang 《Nuclear Science and Techniques》 2025年第3期146-156,共11页
This study investigates photonuclear reaction(γ,n)cross-sections using Bayesian neural network(BNN)analysis.After determining the optimal network architecture,which features two hidden layers,each with 50 hidden node... This study investigates photonuclear reaction(γ,n)cross-sections using Bayesian neural network(BNN)analysis.After determining the optimal network architecture,which features two hidden layers,each with 50 hidden nodes,training was conducted for 30,000 iterations to ensure comprehensive data capture.By analyzing the distribution of absolute errors positively correlated with the cross-section for the isotope 159Tb,as well as the relative errors unrelated to the cross-section,we confirmed that the network effectively captured the data features without overfitting.Comparison with the TENDL-2021 Database demonstrated the BNN's reliability in fitting photonuclear cross-sections with lower average errors.The predictions for nuclei with single and double giant dipole resonance peak cross-sections,the accurate determination of the photoneutron reaction threshold in the low-energy region,and the precise description of trends in the high-energy cross-sections further demonstrate the network's generalization ability on the validation set.This can be attributed to the consistency of the training data.By using consistent training sets from different laboratories,Bayesian neural networks can predict nearby unknown cross-sections based on existing laboratory data,thereby estimating the potential differences between other laboratories'existing data and their own measurement results.Experimental measurements of photonuclear reactions on the newly constructed SLEGS beamline will contribute to clarifying the differences in cross-sections within the existing data. 展开更多
关键词 Photoneutron reaction Bayesian neural network Machine learning Gamma source SLEGS
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Perturbation response scanning of drug-target networks:Drug repurposing for multiple sclerosis 被引量:1
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作者 Yitan Lu Ziyun Zhou +10 位作者 Qi Li Bin Yang Xing Xu Yu Zhu Mengjun Xie Yuwan Qi Fei Xiao Wenying Yan Zhongjie Liang Qifei Cong Guang Hu 《Journal of Pharmaceutical Analysis》 2025年第6期1277-1290,共14页
Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-targe... Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-target networks(DTNs),which could provide a promising avenue in network medicine.We demonstrated the utility of the method by introducing a deep learning and network perturbation-based framework,for drug repurposing of multiple sclerosis(MS).First,the MS comorbidity network was constructed by performing a random walk with restart algorithm based on shared genes between MS and other diseases as seed nodes.Then,based on topological analysis and functional annotation,the neurotransmission module was identified as the“therapeutic module”of MS.Further,perturbation scores of drugs on the module were calculated by constructing the DTN and introducing the PRS analysis,giving a list of repurposable drugs for MS.Mechanism of action analysis both at pathway and structural levels screened dihydroergocristine as a candidate drug of MS by targeting a serotonin receptor of se-rotonin 2B receptor(HTR2B).Finally,we established a cuprizone-induced chronic mouse model to evaluate the alteration of HTR2B in mouse brain regions and observed that HTR2B was significantly reduced in the cuprizone-induced mouse cortex.These findings proved that the network perturbation modeling is a promising avenue for drug repurposing of MS.As a useful systematic method,our approach can also be used to discover the new molecular mechanism and provide effective candidate drugs for other complex diseases. 展开更多
关键词 network perturbations Mechanism of action Multiple sclerosis HTR2B
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