This study mainly interprets Feng Youlan’s“Theory of Life Realm”from the perspective of psychotherapy,redefining the concepts of“juejie”(awareness and understanding)and the criteria for realm classification.“Jue...This study mainly interprets Feng Youlan’s“Theory of Life Realm”from the perspective of psychotherapy,redefining the concepts of“juejie”(awareness and understanding)and the criteria for realm classification.“Juejie”has two meanings:the psychological activity of processing cognitive objects and the awareness of the spirit itself.Realm is inherently a spatial-temporal concept.According to people’s different time,space,and awakening levels,realm can be divided into clearer spatial-temporal dimensions.Such classification is more conducive to grasping its essence and realizing realm transformation.This study improves Feng Youlan’s“Theory of Life Realm”and realizes the possibility of constructing a Chinese-style psychotherapy paradigm through the realm theory.展开更多
Inspired by tug-of-war,a game-changing bone-tendon fixation paradigm was developed.Specifically,injectable citrate-based bioactive self-expansive and planar-fixing screw(iCSP-Scr)consisting of reactive isocyanate(NCO)...Inspired by tug-of-war,a game-changing bone-tendon fixation paradigm was developed.Specifically,injectable citrate-based bioactive self-expansive and planar-fixing screw(iCSP-Scr)consisting of reactive isocyanate(NCO)terminalized citrate-based polyurethane,proanthocyanidin modified hydroxyapatite(HAp)and water(with/without porogen)was developed and administrated in the bone-tendon gap.Instead of the“point to point”tendon fixation by traditional interface screws,along with the moisture-induced crosslinking and expansion of iCSP-Scr within the confined space of the irregularly shaped bone-tendon gap,the tendon graft was evenly squeezed into the bone tunnel in a“surface to surface”manner to realize strong and stable bone-tendon fixation via physical expansion,mechanical interlocking and chemical bonding(between–NCO and the–NH2,–SH groups on bone matrix).The optimized iCSP-Scr exhibited rapid crosslinking,moderate expansion rate,high porosity after crosslinking,as well as tunable elasticity and toughness.The iCSP-Scr possessed favorable biodegradability,biocompatibility,and osteoinductivity derived from citrate,PC and HAp,it was able to promote osteogenesis and new bone growth inward of bone tunnel thus further enhanced the bone/iCSP-Scr mechanical interlock,ultimately leading to stronger tendon fixation(pull-out force 106.15±23.15 N)comparing to titanium screws(93.76±17.89 N)after 14 weeks’ACL reconstruction in a rabbit model.The iCSP-Scr not only can be used as a self-expansive screw facilitating bone-tendon healing,but also can be expanded into other osteogenic application scenarios.展开更多
文摘This study mainly interprets Feng Youlan’s“Theory of Life Realm”from the perspective of psychotherapy,redefining the concepts of“juejie”(awareness and understanding)and the criteria for realm classification.“Juejie”has two meanings:the psychological activity of processing cognitive objects and the awareness of the spirit itself.Realm is inherently a spatial-temporal concept.According to people’s different time,space,and awakening levels,realm can be divided into clearer spatial-temporal dimensions.Such classification is more conducive to grasping its essence and realizing realm transformation.This study improves Feng Youlan’s“Theory of Life Realm”and realizes the possibility of constructing a Chinese-style psychotherapy paradigm through the realm theory.
基金Youth Talent of Guangdong Special Support Program(0620220207)Natural Science Foundation of China(Grant Nos.U21A2099,82272453,and 82102545)+2 种基金China Postdoctoral Science Foundation(Grant No.2022M721515)Basic and Applied Basic Research Project of Guangzhou City(202201011774)Open Program from Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Disease.
文摘Inspired by tug-of-war,a game-changing bone-tendon fixation paradigm was developed.Specifically,injectable citrate-based bioactive self-expansive and planar-fixing screw(iCSP-Scr)consisting of reactive isocyanate(NCO)terminalized citrate-based polyurethane,proanthocyanidin modified hydroxyapatite(HAp)and water(with/without porogen)was developed and administrated in the bone-tendon gap.Instead of the“point to point”tendon fixation by traditional interface screws,along with the moisture-induced crosslinking and expansion of iCSP-Scr within the confined space of the irregularly shaped bone-tendon gap,the tendon graft was evenly squeezed into the bone tunnel in a“surface to surface”manner to realize strong and stable bone-tendon fixation via physical expansion,mechanical interlocking and chemical bonding(between–NCO and the–NH2,–SH groups on bone matrix).The optimized iCSP-Scr exhibited rapid crosslinking,moderate expansion rate,high porosity after crosslinking,as well as tunable elasticity and toughness.The iCSP-Scr possessed favorable biodegradability,biocompatibility,and osteoinductivity derived from citrate,PC and HAp,it was able to promote osteogenesis and new bone growth inward of bone tunnel thus further enhanced the bone/iCSP-Scr mechanical interlock,ultimately leading to stronger tendon fixation(pull-out force 106.15±23.15 N)comparing to titanium screws(93.76±17.89 N)after 14 weeks’ACL reconstruction in a rabbit model.The iCSP-Scr not only can be used as a self-expansive screw facilitating bone-tendon healing,but also can be expanded into other osteogenic application scenarios.
