Chronic ophthalmic diseases are multivariate,time-varying,and degenerative.Smart contact lenses have emerged as a scalable platform for noninvasive ocular signal detection and disease diagnosis.However,real-time monit...Chronic ophthalmic diseases are multivariate,time-varying,and degenerative.Smart contact lenses have emerged as a scalable platform for noninvasive ocular signal detection and disease diagnosis.However,real-time monitoring and decoupling of multiple ocular parameters,particularly when the eyes are closed,remain challenging in clinical medicine.In this work,we propose a stretchable bimodal contact lens(BCL)amalgamating self-decoupled electromagnetic capacitive intraocular pressure(CIOP)and magnetic eye movement(MEM)monitoring components.The sandwich-integrated BCL can be intimately attached to the eyeball,enabling closed-eye,wireless,and precise signal acquisition without interference.During the eye open and closed,the serpentine-geometry CIOP unit was validated on a rabbit model,achieving supered resolution(1 mmHg)and sensitivity(≥0.22 MHz mmHg^(-1))for reversible hypo-to hyper-IOP fluctuations.Ex vivo and in vivo MEM monitoring,based on composition-optimized magnetic interlayer film,demonstrated exceptional accuracy(≥97.25%)with eyes open and closed,surpassing existing methods.The collected CIOP and MEM data could be wirelessly aggregated and transmitted to portable devices via integrated acquisition modules within frame glasses for real-time eye healthcare.Emerging noninvasive and bimodal modalities reconcile the trade-off between minimal discomfort,eye status,and reliable measurement,spurring the widespread adoption of the integrated monitoring system for continuous ocular health monitoring.展开更多
基金supported by the National Natural Science Foundation of China under grant numbers 62422104,U21A20460,62371115,52021001Science and Technology Major Project of Tibetan Autonomous Region of China under grant no.XZ202201ZD0001G+1 种基金Science and Technology Department of Sichuan Province under grant no.2024NSFSC0234the Medico-Engineering Cooperation Funds,Fundamental Research Funds for the Central Universities,UESTC under grant nos.ZYGX2020ZB041,ZYGX2021YGLH002.
文摘Chronic ophthalmic diseases are multivariate,time-varying,and degenerative.Smart contact lenses have emerged as a scalable platform for noninvasive ocular signal detection and disease diagnosis.However,real-time monitoring and decoupling of multiple ocular parameters,particularly when the eyes are closed,remain challenging in clinical medicine.In this work,we propose a stretchable bimodal contact lens(BCL)amalgamating self-decoupled electromagnetic capacitive intraocular pressure(CIOP)and magnetic eye movement(MEM)monitoring components.The sandwich-integrated BCL can be intimately attached to the eyeball,enabling closed-eye,wireless,and precise signal acquisition without interference.During the eye open and closed,the serpentine-geometry CIOP unit was validated on a rabbit model,achieving supered resolution(1 mmHg)and sensitivity(≥0.22 MHz mmHg^(-1))for reversible hypo-to hyper-IOP fluctuations.Ex vivo and in vivo MEM monitoring,based on composition-optimized magnetic interlayer film,demonstrated exceptional accuracy(≥97.25%)with eyes open and closed,surpassing existing methods.The collected CIOP and MEM data could be wirelessly aggregated and transmitted to portable devices via integrated acquisition modules within frame glasses for real-time eye healthcare.Emerging noninvasive and bimodal modalities reconcile the trade-off between minimal discomfort,eye status,and reliable measurement,spurring the widespread adoption of the integrated monitoring system for continuous ocular health monitoring.
