Chinese materia medica(CMM) compatibility is one core content in the theory of Traditional Chinese Medicine(TCM), and elaborating the scientific connotation of CMM compatibility is of great significance to promote the...Chinese materia medica(CMM) compatibility is one core content in the theory of Traditional Chinese Medicine(TCM), and elaborating the scientific connotation of CMM compatibility is of great significance to promote the modernization of TCM. Self-assembly is the combination of active ingredients into aggregates through noncovalent bonds, such as hydrogen bonding, electrostatic interactions, ionic interactions, and hydrophobic interactions. The complex properties and special structures of CMM components create the basis for selfassembly. The self-assembled materials formed after CMM compatibility is an important part of the material basis for the efficacy of TCM, which can help explain the scientific connotations of CMM compatibility. This review summarizes the self-assembly phenomenon from the perspective of drug pair combinations in recent decades and explains the scientific connotation of CMM compatibility about the material basis, pharmacodynamic changes, and mechanism of action, providing new ideas and methods for the study of TCM.展开更多
To achieve fire-resistant epoxy resin(EP),a UiO-66-based novel flame retardant coating(CS@APP@UiO-66)was prepared by modifying UiO-66 with chitosan(CS)and ammonium polyphosphate(APP)through a layer-by-layer(LbL)self-a...To achieve fire-resistant epoxy resin(EP),a UiO-66-based novel flame retardant coating(CS@APP@UiO-66)was prepared by modifying UiO-66 with chitosan(CS)and ammonium polyphosphate(APP)through a layer-by-layer(LbL)self-assembly method,which was then introduced into an EP system to improve its fire safety.The results of scanning electron microscopy,X-ray diffraction and Fourier transform infrared spectroscopy show that the unsaturated Zr atoms in the UiO-66 framework provide many active sites conducive to modification,so that the UiO-66 particles,which originally had a regular octahedral structure,are more dispersed by LbL modification without causing doping or distortion issues.The thermogravimetric analysis results indicate that the char residue of EP/2%UiO-66 is increased by 2.52%compared with that of pure EP,indicating that the thermal properties of the EP composite are improved after modification.In addition,the cone test results indicate that EP/2%UiO-66-5L has good flame retardancy and smoke suppression properties,and the peak heat release rate,total smoke production and rate of CO generation values are 25.2%,5.7%and 38.5%lower than those of the unmodified EP.Moreover,it can be concluded from the Raman test that the graphitization degree of the modified EP composite is strengthened.The above results indicated that after the incorporation of CS@APP@UiO-66 into the EP composites,more char layers formed as physical barriers to prevent the transfer of mass and heat,thus reducing the speed of flame propagation.Therefore,the flame resistance and smoke suppression of the EP composites improved.These favorable characteristics,including high flame retardant efficiency and good smoke suppression,make LbL-functionalized UiO-66 promising for flame retardant polymer applications.展开更多
The 6-isoquinolinyl system was incorporated into mechanically interlocked molecules(MIMs)syntheses for comparative analysis of its assembly behavior with 4-pyridyl-based coordination ligands,where a coordination-drive...The 6-isoquinolinyl system was incorporated into mechanically interlocked molecules(MIMs)syntheses for comparative analysis of its assembly behavior with 4-pyridyl-based coordination ligands,where a coordination-driven self-assembly strategy by half-sandwich Cp^(*)Rh units was employed to construct diverse molecular links.The pyridyl ligand,adorned with thiophene moieties,assembles into[2]catenanes(2_(1)^(2)links),whereas the isoquinolinyl ligand produces molecular Borromean links(6_(2)^(3)links).Intriguingly,when utilizing extended bithiophene segments,the pyridyl ligand forms Borromean rings(6_(2)^(3)links),while isoquinolinyl counterparts produced a rare low-symmetry cyclic[3]catenane(6_(3)^(3)topology).The results were confirmed through single-crystal X-ray diffraction analysis,nuclear magnetic resonance(NMR)spectroscopy,and electrospray ionization time-of-flight mass spectrometry(ESI-TOF/MS)experiments.Synergistic π-π stacking,C-H···π interactions,and solvophobic effects governed the complex self-assembly system,with independent gradient model(IGM)analyses and solventaccessible surface area(SASA)calculations providing atomistic insights into the pathway selectivity of distinct topological links.展开更多
Ocean geoscience is a highly integrated and interdisciplinary field that plays a critical role in understanding the interaction between Earth’s lithosphere,hydrosphere,atmosphere,biosphere,and anthroposphere.Recent y...Ocean geoscience is a highly integrated and interdisciplinary field that plays a critical role in understanding the interaction between Earth’s lithosphere,hydrosphere,atmosphere,biosphere,and anthroposphere.Recent years have seen tremendous progress in global ocean research,driven by rapid advancements in deep-sea manned and unmanned submersibles,ocean drilling,seafloor observatories,big data assimilation,and supercomputing simulations.Representative examples of breakthroughs are highlighted in this work:(1)Probing sub-seafloor processes.A 10,000-meter ocean-bottom seismometer array has achieved high-resolution imaging of the deepest ocean on the Earth-the Challenger Deep of the Mariana Trench,revealing the role of key tectonic and hydrological processes within the subduction zone.The first sub-ice seafloor seismic and magnetotelluric experiments were successfully conducted at the Arctic Gakkel Ridge,providing significant insights into the dynamics of ultraslow seafloor spreading.(2)Exploration of seafloor resources.Near-seafloor investigations employing underwater robotics and multi-sensor systems have been carried out in areas of hydrothermal vents and cold seeps at global locations,including the Southwest Indian Ridge.These efforts have combined geophysical,oceanographic,chemical,and biological observations with extensive seafloor sampling.(3)Interdisciplinary research of complex catastrophic events.High-resolution simulations integrating ocean observations with supercomputing modeling have made it possible to fully model earthquake-induced seafloor deformation,tsunami propagation,and ocean basin-scale transport of the Fukushima Power Plant-derived radionuclides associated with the 2011 Tohoku earthquake.Among the world’s three major oceans,the Indian Ocean is still relatively underexplored.Major scientific challenges include elucidating crust-mantle interaction,air-sea dynamic coupling,large-scale marine hazards,and responses of ecosystems to major environmental changes,all of which require interdisciplinary collaboration.Future efforts should focus on developing intelligent unmanned observation platform systems,big data and digital twins,and AI-driven hazard modeling.Meanwhile,higher educational reforms should emphasize fostering a new generation of students and young scientists with a solid background and strong critical analysis skills to accelerate technological innovation.展开更多
Controllable photoreaction transition of photosensitizers(PSs)provides a highly promising approach for achieving efficient photodynamic therapy(PDT).However,tumor microenvironment-triggered phototransition remains a s...Controllable photoreaction transition of photosensitizers(PSs)provides a highly promising approach for achieving efficient photodynamic therapy(PDT).However,tumor microenvironment-triggered phototransition remains a significant challenge and has not yet been reported.In this work,we develop a hydrogen bond self-assembly(HBSA)strategy that is triggered by the acidic tumor microenvironment to enable the photodynamic transition of tetra(4-carboxylphenyl)porphyrin(TCPP)PSs from type Ⅱ to type Ⅰ reactions.Upon self-assembly of TCPP monomers into TCPP assemblies(TCPP-ass),the generated reactive oxygen species shift from singlet oxygen to superoxide anions,which induces caspase-3/GSDME-mediated programmed pyroptosis,enabling rapid and complete solid tumor elimination with minimized adverse effects and enhanced therapeutic efficacy.Crucially,the HBSA process occurs exclusively within tumor cells,and this tumor-specific self-assembly strategy not only utilizes high tissue penetration of TCPP molecular-PSs,but also avoids phototoxicity caused by the formation and accumulation of TCPP-ass nano-PSs in normal tissue,providing an innovative approach for precise cancer therapy.展开更多
Two supramolecular organic frameworks(SOFs)have been constructed from the co-assembly of biimidazolium-derived octacationic components and cucurbit[8]uril in water.Dynamic light scattering and ^(1)H NMR experiments re...Two supramolecular organic frameworks(SOFs)have been constructed from the co-assembly of biimidazolium-derived octacationic components and cucurbit[8]uril in water.Dynamic light scattering and ^(1)H NMR experiments reveal that both SOFs can undergo reversible assembly and disassembly at room temperature.One of the SOFs displays unprecedently high maximum tolerated dose of 120 mg/kg with mice,which improves by 40%compared with the highest value of the reported SOFs.In vitro and in vivo tests show that the SOF can adsorb doxorubicin and overcome the resistance of multidrugresistant MDR A549/ADR tumor cells to realize intracellular delivery,leading to enhanced antitumor efficacy.Moreover,it can also completely inhibit the posttreatment phototoxicity of photofrin and fully neutralize the anticoagulation of both unfractionated heparin and low molecular weight heparins through efficient inclusion and elimination or sequestration mechanism.As the first examples that undergo roomtemperature reversible assembly and disassembly,the new SOFs in principle allow for quantitative analysis of the molecular components in the body that is prerequisite for preclinical evaluation in the future.展开更多
With the accelerating aging process of China’s population,the demand for community elderly care services has shown diversified and personalized characteristics.However,problems such as insufficient total care service...With the accelerating aging process of China’s population,the demand for community elderly care services has shown diversified and personalized characteristics.However,problems such as insufficient total care service resources,uneven distribution,and prominent supply-demand contradictions have seriously affected service quality.Big data technology,with core advantages including data collection,analysis and mining,and accurate prediction,provides a new solution for the allocation of community elderly care service resources.This paper systematically studies the application value of big data technology in the allocation of community elderly care service resources from three aspects:resource allocation efficiency,service accuracy,and management intelligence.Combined with practical needs,it proposes optimal allocation strategies such as building a big data analysis platform and accurately grasping the elderly’s care needs,striving to provide operable path references for the construction of community elderly care service systems,promoting the early realization of the elderly care service goal of“adequate support and proper care for the elderly”,and boosting the high-quality development of China’s elderly care service industry.展开更多
The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them w...The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them was not a typical exhibition hall,but a building shaped like a gleaming stainless-steel cooking pot.展开更多
Jeanologia celebrated its 30th anniversary reaffirming the mission it was born with in 1994,to transform the textile industry into a more sustainable,efficient,and human-centered sector.Three decades later,that vision...Jeanologia celebrated its 30th anniversary reaffirming the mission it was born with in 1994,to transform the textile industry into a more sustainable,efficient,and human-centered sector.Three decades later,that vision has become a global reality.Today,more than 40 percent of all jeans produced worldwide are made using technologies developed by the Valencia-based company.What started in a small laboratory in Valencia(Spain),with a pioneering team and a visionary idea,has evolved into a global benchmark in sustainable innovation.From the beginning,Jeanologia believed in technology as a driver of change,introducing solutions that eliminated harmful practices and opened the door to a new,cleaner way of making garments.展开更多
Aiming at the problems of lagging curriculum,weak practice,and single evaluation in the cultivation of HarmonyOS Development talents,this study constructs a“teacher-machine-student”ternary interactive teaching model...Aiming at the problems of lagging curriculum,weak practice,and single evaluation in the cultivation of HarmonyOS Development talents,this study constructs a“teacher-machine-student”ternary interactive teaching model based on the Congyou platform.Through the building block curriculum system,the HarmonyOS technology stack is decoupled into dynamic capability units,and a multi-disciplinary cross-case library is jointly built with Huawei,which significantly improves the synchronization of teaching content and industrial technology.This paper innovatively designs an AI collaborative teaching system,which employs knowledge graphs to plan learning paths,utilizes virtual equipment clusters to simulate development environments,and establishes a“diagnosis-feedback-enhancement”closed loop through AI-based review,thereby effectively improving students’development efficiency and code reuse rate.A three-dimensional evaluation model integrating task outcomes,process performance,and innovation is constructed,incorporating indicators such as code standardization and an innovation index to strengthen the cultivation of engineering thinking and innovative ability.Furthermore,a data-driven support platform is built to generate student competency profiles,open up the“credit-competency-certification”pathway,promote the transformation of course achievements into contributions to the Huawei ecosystem,and significantly shorten the job adaptation cycle for graduates.The research results provide a replicable paradigm for the cultivation of domestic operating system talents.展开更多
Given the growing importance of social media in digital rural development, this study systematically investigated the influence pathways of social media use among rural women in China, drawing on the Technology Accept...Given the growing importance of social media in digital rural development, this study systematically investigated the influence pathways of social media use among rural women in China, drawing on the Technology Acceptance Model(TAM). Employing quantitative research methods, the study conducted empirical tests based on 367 valid questionnaires using Partial Least Squares Structural Equation Modeling(PLS-SEM) via SmartPLS 4.0 software. Results indicate that significant associations exist between perceived ease of use, perceived usefulness, attitudes toward use, behavioral intention, and actual usage behavior. Specifically, the study finds that rural women's perceived ease of use of social media has a significant and positive influence on both perceived usefulness and attitudes toward use. Perceived usefulness further significantly promotes attitudes toward use and behavioral intention. Moreover, positive attitudes toward usage and strong behavioral intentions were effectively converted into actual social media usage behaviors. This study not only validates the applicability and explanatory power of the TAM model in understanding the digital behavior of Chinese rural women but also provides quantitative evidence for how social media enhances their “digital visibility.” These findings offer practical insights for governments and platform providers to optimize user experiences and strengthen digital skills training. Despite its limitations, including a cross-sectional design and a regional sample, this research holds significant theoretical and practical implications.展开更多
Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide ...Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide technology for good and prevent and control technological risks has become an important issue of global concern.Research on science and technology ethics is dedicated to integrating ethical theories into governance practices and constructing ethical models that adapt to the development of the times.Methods:This article systematically reviews the six core approaches of scientific and technological ethics thought,including technological autonomy and political philosophy criticism,responsibility ethics and intergenerational obligations,technological intermediation and the integration of life and the world,ethical principles and normative frameworks,participatory governance and ethical practice innovation,as well as domain-specific ethical norms,thereby constructing an ethical analysis framework applicable to medical technology risks.And cross-analysis was conducted by taking medical events such as gene editing and xenotransplantation as examples.Results:Research shows that a single ethical approach has limitations in addressing complex medical ethical challenges,while the six approaches are complementary and synergistic.By criticizing technological autonomy,establishing a responsibility ethics orientation,setting the bottom line of ethical principles,promoting participatory governance,formulating domain norms,and continuously reflecting on the intermediary nature of technology,a multi-level and dynamically adaptive governance system for scientific and technological ethics can be constructed.Conclusion:The key to addressing contemporary medical ethics challenges lies in the comprehensive application of science and technology ethics theories and the integration of ethical considerations throughout the entire process of scientific and technological research and development.In the future,a governance framework that adapts to the development of new technologies should be established to promote cross-cultural and cross-disciplinary ethical dialogue and public participation,ensuring that scientific and technological innovation always serves the dignity of human life and overall well-being.展开更多
Against the backdrop of integrated development between technical education and higher vocational education,the teaching of Chinese Medicine Processing Technology courses faces new opportunities and challenges.This pap...Against the backdrop of integrated development between technical education and higher vocational education,the teaching of Chinese Medicine Processing Technology courses faces new opportunities and challenges.This paper analyzes the existing problems in the current teaching of Chinese Medicine Processing Technology courses,discusses the necessity of reforming the teaching model under the context of integration,and proposes the construction of a"Dual-Capability Progression,Six-Dimensional Empowerment"teaching model.The aim is to enhance the teaching quality of Chinese Medicine Processing Technology courses and cultivate high-quality skilled talents in Chinese medicine processing who can meet industry demands.展开更多
Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly b...Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly becoming the preferred choice of physicians and patients for point-of-care testing due to its simplicity,cost-effectiveness,and rapid detection.Observing the optical signal change from the colloidal gold of the traditional LFIA strip has been widely applied for various biomarkers detection in body fluids.Despite the significant progress,rapid real-time detection of color changes in the colloidal gold by the naked eye still faces many limitations,such as large errors and the inability to quantify and accurately detect.New optical LFIA strip technology has emerged in recent years to extend its application scenarios for achieving quantitative detection such as fluorescence,afterglow,and chemiluminescence.Herein,we summarized the development of optical LFIA technology from single to hyphenated optical signals for biomarkers detection in body fluids from invasive and non-invasive sources.Moreover,the challenge and outlook of optical LFIA strip technology are highlighted to inspire the designing of next-generation diagnostic platforms.展开更多
Whole Slide Imaging (WSI) technology, as a revolutionary digital technology in the field of pathology, is gradually changing the traditional clinical pathological diagnosis model. By converting traditional glass patho...Whole Slide Imaging (WSI) technology, as a revolutionary digital technology in the field of pathology, is gradually changing the traditional clinical pathological diagnosis model. By converting traditional glass pathological sections into complete digital images through high-resolution scanning, it provides a new method for pathological diagnosis. Based on this, this paper studies the application of WSI technology in clinical pathological diagnosis, elaborates on its application value, analyzes the current application status, and proposes corresponding application countermeasures, aiming to provide reference for the standardized and popularized development of this technology in clinical pathological diagnosis.展开更多
Defence Technology(ISSN 2214-9147(O);2096-3459(P)),sponsored by China Ordnance Society,is published monthly and aims to become one of the well-known comprehensive journals in the world,which reports on the breakthroug...Defence Technology(ISSN 2214-9147(O);2096-3459(P)),sponsored by China Ordnance Society,is published monthly and aims to become one of the well-known comprehensive journals in the world,which reports on the breakthroughs in defence technology by building up an international academic exchange platform for the defence technology related research.It publishes original research papers having direct bearing on defence,with a balanced coverage on analytical,experimental,numerical simulation and applied investigations.It covers various disciplines of science,technology and engineering.展开更多
The Sn−2Al filler metal was utilized to bond W90 tungsten heavy alloys by the ultrasonic-assisted coating technology in atmospheric environment at 250℃.The effects of ultrasonic power and ultrasonic time on microstru...The Sn−2Al filler metal was utilized to bond W90 tungsten heavy alloys by the ultrasonic-assisted coating technology in atmospheric environment at 250℃.The effects of ultrasonic power and ultrasonic time on microstructure and interfacial strength of Sn−2Al/W90 interface were investigated.The ultrasound improved the wettability of Sn−2Al filler metal on W90 surface.As the ultrasonic power increased and ultrasonic time increased,the size of Al phase in seam decreased.The maximum value of Sn−2Al/W90 interfacial strength reached 30.1 MPa.Based on the acoustic pressure simulation and bubble dynamics,the intensity of cavitation effect was proportional to ultrasonic power.The generated high temperature and high pressure by cavitation effect reached 83799.6 K and 1.26×10^(14) Pa,respectively.展开更多
In recent years,microfluidic technology has emerged as a powerful and innovative tool,attracting significant attention for its ability to provide real-time visualization of CO_(2)flow,mass transfer,and reaction proces...In recent years,microfluidic technology has emerged as a powerful and innovative tool,attracting significant attention for its ability to provide real-time visualization of CO_(2)flow,mass transfer,and reaction processes in porous media.This review examines the application of microfluidic technology in CO_(2)sequestration in saline aquifers,emphasizing the advantages of saline aquifer for geological sequestration,including safety,high storage capacity,stability,and cost-effectiveness.The materials used for microfluidic chips and the design of microchannels are systematically reviewed,offering forward-looking recommendations for chip selection and microchannel characterization in future research on CO_(2)sequestration in saline aquifer.Based on a detailed analysis of advancements in microfluidic technology,this review highlights key findings related to CO_(2)trapping mechanisms,salt precipitation,and CO_(2)-water-rock chemical interactions within saline aquifers.Although microfluidic technology shows great promise in these areas,this review identifies limitations in current studies and outlines future research directions,aiming to promote further innovation and broader application of microfluidic technology in the field of CO_(2)sequestration in saline aquifer.展开更多
Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biot...Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biotechnology and its applications in the field of neuropsychiatry.Available evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin deficit.In vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric diseases.Although the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic applications.However,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical applications.This review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.展开更多
基金the Science and Technology Innovation Project of the China Academy of Chinese Medical Sciences:Establishment of Research Methods for Protein Supramolecular Components in Chinese Medicine decoctionC12021A00108Independent Selection Project of Institute of Basic Theory of Chinese Medicine,China Academy of Chinese Medical Sciences:Exploration and Case Study of the Research Model of"Theory and Experiment"on the Compatibility of Traditional Chinese Medicine,YZ-202109。
文摘Chinese materia medica(CMM) compatibility is one core content in the theory of Traditional Chinese Medicine(TCM), and elaborating the scientific connotation of CMM compatibility is of great significance to promote the modernization of TCM. Self-assembly is the combination of active ingredients into aggregates through noncovalent bonds, such as hydrogen bonding, electrostatic interactions, ionic interactions, and hydrophobic interactions. The complex properties and special structures of CMM components create the basis for selfassembly. The self-assembled materials formed after CMM compatibility is an important part of the material basis for the efficacy of TCM, which can help explain the scientific connotations of CMM compatibility. This review summarizes the self-assembly phenomenon from the perspective of drug pair combinations in recent decades and explains the scientific connotation of CMM compatibility about the material basis, pharmacodynamic changes, and mechanism of action, providing new ideas and methods for the study of TCM.
基金support by the Textile Light Applied Basic Research Project(Grant No.J202107)the Doctor Project of Innovation and Entrepreneurship in Jiangsu Province(Grant No.JSSCBS20210821)+1 种基金the National Natural Science Foundation of China(Grant No.22205082)the Natural Science Foundation of Jiangsu Province(Grant No.BK20221098).
文摘To achieve fire-resistant epoxy resin(EP),a UiO-66-based novel flame retardant coating(CS@APP@UiO-66)was prepared by modifying UiO-66 with chitosan(CS)and ammonium polyphosphate(APP)through a layer-by-layer(LbL)self-assembly method,which was then introduced into an EP system to improve its fire safety.The results of scanning electron microscopy,X-ray diffraction and Fourier transform infrared spectroscopy show that the unsaturated Zr atoms in the UiO-66 framework provide many active sites conducive to modification,so that the UiO-66 particles,which originally had a regular octahedral structure,are more dispersed by LbL modification without causing doping or distortion issues.The thermogravimetric analysis results indicate that the char residue of EP/2%UiO-66 is increased by 2.52%compared with that of pure EP,indicating that the thermal properties of the EP composite are improved after modification.In addition,the cone test results indicate that EP/2%UiO-66-5L has good flame retardancy and smoke suppression properties,and the peak heat release rate,total smoke production and rate of CO generation values are 25.2%,5.7%and 38.5%lower than those of the unmodified EP.Moreover,it can be concluded from the Raman test that the graphitization degree of the modified EP composite is strengthened.The above results indicated that after the incorporation of CS@APP@UiO-66 into the EP composites,more char layers formed as physical barriers to prevent the transfer of mass and heat,thus reducing the speed of flame propagation.Therefore,the flame resistance and smoke suppression of the EP composites improved.These favorable characteristics,including high flame retardant efficiency and good smoke suppression,make LbL-functionalized UiO-66 promising for flame retardant polymer applications.
基金supported by the Department of Chemistry,Fudan Universitythe National Natural Science Foundation of China(22031003,21720102004)the Shanghai Science Technology Committee(19DZ2270100)。
文摘The 6-isoquinolinyl system was incorporated into mechanically interlocked molecules(MIMs)syntheses for comparative analysis of its assembly behavior with 4-pyridyl-based coordination ligands,where a coordination-driven self-assembly strategy by half-sandwich Cp^(*)Rh units was employed to construct diverse molecular links.The pyridyl ligand,adorned with thiophene moieties,assembles into[2]catenanes(2_(1)^(2)links),whereas the isoquinolinyl ligand produces molecular Borromean links(6_(2)^(3)links).Intriguingly,when utilizing extended bithiophene segments,the pyridyl ligand forms Borromean rings(6_(2)^(3)links),while isoquinolinyl counterparts produced a rare low-symmetry cyclic[3]catenane(6_(3)^(3)topology).The results were confirmed through single-crystal X-ray diffraction analysis,nuclear magnetic resonance(NMR)spectroscopy,and electrospray ionization time-of-flight mass spectrometry(ESI-TOF/MS)experiments.Synergistic π-π stacking,C-H···π interactions,and solvophobic effects governed the complex self-assembly system,with independent gradient model(IGM)analyses and solventaccessible surface area(SASA)calculations providing atomistic insights into the pathway selectivity of distinct topological links.
基金supported by the National Natural Science Foundation of China(Grant No.92258303)the National Key Research and Development Program of China(Grant Nos.2024YFF0506704 and 2023YFF0803404).
文摘Ocean geoscience is a highly integrated and interdisciplinary field that plays a critical role in understanding the interaction between Earth’s lithosphere,hydrosphere,atmosphere,biosphere,and anthroposphere.Recent years have seen tremendous progress in global ocean research,driven by rapid advancements in deep-sea manned and unmanned submersibles,ocean drilling,seafloor observatories,big data assimilation,and supercomputing simulations.Representative examples of breakthroughs are highlighted in this work:(1)Probing sub-seafloor processes.A 10,000-meter ocean-bottom seismometer array has achieved high-resolution imaging of the deepest ocean on the Earth-the Challenger Deep of the Mariana Trench,revealing the role of key tectonic and hydrological processes within the subduction zone.The first sub-ice seafloor seismic and magnetotelluric experiments were successfully conducted at the Arctic Gakkel Ridge,providing significant insights into the dynamics of ultraslow seafloor spreading.(2)Exploration of seafloor resources.Near-seafloor investigations employing underwater robotics and multi-sensor systems have been carried out in areas of hydrothermal vents and cold seeps at global locations,including the Southwest Indian Ridge.These efforts have combined geophysical,oceanographic,chemical,and biological observations with extensive seafloor sampling.(3)Interdisciplinary research of complex catastrophic events.High-resolution simulations integrating ocean observations with supercomputing modeling have made it possible to fully model earthquake-induced seafloor deformation,tsunami propagation,and ocean basin-scale transport of the Fukushima Power Plant-derived radionuclides associated with the 2011 Tohoku earthquake.Among the world’s three major oceans,the Indian Ocean is still relatively underexplored.Major scientific challenges include elucidating crust-mantle interaction,air-sea dynamic coupling,large-scale marine hazards,and responses of ecosystems to major environmental changes,all of which require interdisciplinary collaboration.Future efforts should focus on developing intelligent unmanned observation platform systems,big data and digital twins,and AI-driven hazard modeling.Meanwhile,higher educational reforms should emphasize fostering a new generation of students and young scientists with a solid background and strong critical analysis skills to accelerate technological innovation.
基金supported by the National Natural Science Foundation of China(22176058)the Science and Technology Commission of Shanghai Municipality(24DX1400200,23ZR1416100,25ZR1401082)+1 种基金the Program of Introducing Talents of Discipline to Universities(B16017)the Fundamental Research Funds for the Central Universities(222201717003)。
文摘Controllable photoreaction transition of photosensitizers(PSs)provides a highly promising approach for achieving efficient photodynamic therapy(PDT).However,tumor microenvironment-triggered phototransition remains a significant challenge and has not yet been reported.In this work,we develop a hydrogen bond self-assembly(HBSA)strategy that is triggered by the acidic tumor microenvironment to enable the photodynamic transition of tetra(4-carboxylphenyl)porphyrin(TCPP)PSs from type Ⅱ to type Ⅰ reactions.Upon self-assembly of TCPP monomers into TCPP assemblies(TCPP-ass),the generated reactive oxygen species shift from singlet oxygen to superoxide anions,which induces caspase-3/GSDME-mediated programmed pyroptosis,enabling rapid and complete solid tumor elimination with minimized adverse effects and enhanced therapeutic efficacy.Crucially,the HBSA process occurs exclusively within tumor cells,and this tumor-specific self-assembly strategy not only utilizes high tissue penetration of TCPP molecular-PSs,but also avoids phototoxicity caused by the formation and accumulation of TCPP-ass nano-PSs in normal tissue,providing an innovative approach for precise cancer therapy.
基金the National Natural Science Foundation of China(No.21921003 for Z.T.L.and 22201293 for S.B.Y.)Shanghai Sailing Program(No.22YF1458300 for S.B.Y.)for financial support。
文摘Two supramolecular organic frameworks(SOFs)have been constructed from the co-assembly of biimidazolium-derived octacationic components and cucurbit[8]uril in water.Dynamic light scattering and ^(1)H NMR experiments reveal that both SOFs can undergo reversible assembly and disassembly at room temperature.One of the SOFs displays unprecedently high maximum tolerated dose of 120 mg/kg with mice,which improves by 40%compared with the highest value of the reported SOFs.In vitro and in vivo tests show that the SOF can adsorb doxorubicin and overcome the resistance of multidrugresistant MDR A549/ADR tumor cells to realize intracellular delivery,leading to enhanced antitumor efficacy.Moreover,it can also completely inhibit the posttreatment phototoxicity of photofrin and fully neutralize the anticoagulation of both unfractionated heparin and low molecular weight heparins through efficient inclusion and elimination or sequestration mechanism.As the first examples that undergo roomtemperature reversible assembly and disassembly,the new SOFs in principle allow for quantitative analysis of the molecular components in the body that is prerequisite for preclinical evaluation in the future.
文摘With the accelerating aging process of China’s population,the demand for community elderly care services has shown diversified and personalized characteristics.However,problems such as insufficient total care service resources,uneven distribution,and prominent supply-demand contradictions have seriously affected service quality.Big data technology,with core advantages including data collection,analysis and mining,and accurate prediction,provides a new solution for the allocation of community elderly care service resources.This paper systematically studies the application value of big data technology in the allocation of community elderly care service resources from three aspects:resource allocation efficiency,service accuracy,and management intelligence.Combined with practical needs,it proposes optimal allocation strategies such as building a big data analysis platform and accurately grasping the elderly’s care needs,striving to provide operable path references for the construction of community elderly care service systems,promoting the early realization of the elderly care service goal of“adequate support and proper care for the elderly”,and boosting the high-quality development of China’s elderly care service industry.
文摘The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them was not a typical exhibition hall,but a building shaped like a gleaming stainless-steel cooking pot.
文摘Jeanologia celebrated its 30th anniversary reaffirming the mission it was born with in 1994,to transform the textile industry into a more sustainable,efficient,and human-centered sector.Three decades later,that vision has become a global reality.Today,more than 40 percent of all jeans produced worldwide are made using technologies developed by the Valencia-based company.What started in a small laboratory in Valencia(Spain),with a pioneering team and a visionary idea,has evolved into a global benchmark in sustainable innovation.From the beginning,Jeanologia believed in technology as a driver of change,introducing solutions that eliminated harmful practices and opened the door to a new,cleaner way of making garments.
文摘Aiming at the problems of lagging curriculum,weak practice,and single evaluation in the cultivation of HarmonyOS Development talents,this study constructs a“teacher-machine-student”ternary interactive teaching model based on the Congyou platform.Through the building block curriculum system,the HarmonyOS technology stack is decoupled into dynamic capability units,and a multi-disciplinary cross-case library is jointly built with Huawei,which significantly improves the synchronization of teaching content and industrial technology.This paper innovatively designs an AI collaborative teaching system,which employs knowledge graphs to plan learning paths,utilizes virtual equipment clusters to simulate development environments,and establishes a“diagnosis-feedback-enhancement”closed loop through AI-based review,thereby effectively improving students’development efficiency and code reuse rate.A three-dimensional evaluation model integrating task outcomes,process performance,and innovation is constructed,incorporating indicators such as code standardization and an innovation index to strengthen the cultivation of engineering thinking and innovative ability.Furthermore,a data-driven support platform is built to generate student competency profiles,open up the“credit-competency-certification”pathway,promote the transformation of course achievements into contributions to the Huawei ecosystem,and significantly shorten the job adaptation cycle for graduates.The research results provide a replicable paradigm for the cultivation of domestic operating system talents.
文摘Given the growing importance of social media in digital rural development, this study systematically investigated the influence pathways of social media use among rural women in China, drawing on the Technology Acceptance Model(TAM). Employing quantitative research methods, the study conducted empirical tests based on 367 valid questionnaires using Partial Least Squares Structural Equation Modeling(PLS-SEM) via SmartPLS 4.0 software. Results indicate that significant associations exist between perceived ease of use, perceived usefulness, attitudes toward use, behavioral intention, and actual usage behavior. Specifically, the study finds that rural women's perceived ease of use of social media has a significant and positive influence on both perceived usefulness and attitudes toward use. Perceived usefulness further significantly promotes attitudes toward use and behavioral intention. Moreover, positive attitudes toward usage and strong behavioral intentions were effectively converted into actual social media usage behaviors. This study not only validates the applicability and explanatory power of the TAM model in understanding the digital behavior of Chinese rural women but also provides quantitative evidence for how social media enhances their “digital visibility.” These findings offer practical insights for governments and platform providers to optimize user experiences and strengthen digital skills training. Despite its limitations, including a cross-sectional design and a regional sample, this research holds significant theoretical and practical implications.
基金supported by the National Key Research and Development Program(Grant No.2024YFA0917200)the Projects of the Chinese Center for Disease Control and Prevention(Grant No.BB2110240093)World Medical History under the Education Innovation Plan of the University of Science and Technology of China(Grant No.2024YCHX07).
文摘Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide technology for good and prevent and control technological risks has become an important issue of global concern.Research on science and technology ethics is dedicated to integrating ethical theories into governance practices and constructing ethical models that adapt to the development of the times.Methods:This article systematically reviews the six core approaches of scientific and technological ethics thought,including technological autonomy and political philosophy criticism,responsibility ethics and intergenerational obligations,technological intermediation and the integration of life and the world,ethical principles and normative frameworks,participatory governance and ethical practice innovation,as well as domain-specific ethical norms,thereby constructing an ethical analysis framework applicable to medical technology risks.And cross-analysis was conducted by taking medical events such as gene editing and xenotransplantation as examples.Results:Research shows that a single ethical approach has limitations in addressing complex medical ethical challenges,while the six approaches are complementary and synergistic.By criticizing technological autonomy,establishing a responsibility ethics orientation,setting the bottom line of ethical principles,promoting participatory governance,formulating domain norms,and continuously reflecting on the intermediary nature of technology,a multi-level and dynamically adaptive governance system for scientific and technological ethics can be constructed.Conclusion:The key to addressing contemporary medical ethics challenges lies in the comprehensive application of science and technology ethics theories and the integration of ethical considerations throughout the entire process of scientific and technological research and development.In the future,a governance framework that adapts to the development of new technologies should be established to promote cross-cultural and cross-disciplinary ethical dialogue and public participation,ensuring that scientific and technological innovation always serves the dignity of human life and overall well-being.
基金Supported by Scientific Research Fund Project of Yunnan Provincial Department of Education(2025J1950).
文摘Against the backdrop of integrated development between technical education and higher vocational education,the teaching of Chinese Medicine Processing Technology courses faces new opportunities and challenges.This paper analyzes the existing problems in the current teaching of Chinese Medicine Processing Technology courses,discusses the necessity of reforming the teaching model under the context of integration,and proposes the construction of a"Dual-Capability Progression,Six-Dimensional Empowerment"teaching model.The aim is to enhance the teaching quality of Chinese Medicine Processing Technology courses and cultivate high-quality skilled talents in Chinese medicine processing who can meet industry demands.
基金supported by the National Natural Science Foundation of China (Nos.22234005,22494632,22404081)the Natural Science Foundation of Jiangsu Province (Nos.BK20222015,BK20240534)。
文摘Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly becoming the preferred choice of physicians and patients for point-of-care testing due to its simplicity,cost-effectiveness,and rapid detection.Observing the optical signal change from the colloidal gold of the traditional LFIA strip has been widely applied for various biomarkers detection in body fluids.Despite the significant progress,rapid real-time detection of color changes in the colloidal gold by the naked eye still faces many limitations,such as large errors and the inability to quantify and accurately detect.New optical LFIA strip technology has emerged in recent years to extend its application scenarios for achieving quantitative detection such as fluorescence,afterglow,and chemiluminescence.Herein,we summarized the development of optical LFIA technology from single to hyphenated optical signals for biomarkers detection in body fluids from invasive and non-invasive sources.Moreover,the challenge and outlook of optical LFIA strip technology are highlighted to inspire the designing of next-generation diagnostic platforms.
文摘Whole Slide Imaging (WSI) technology, as a revolutionary digital technology in the field of pathology, is gradually changing the traditional clinical pathological diagnosis model. By converting traditional glass pathological sections into complete digital images through high-resolution scanning, it provides a new method for pathological diagnosis. Based on this, this paper studies the application of WSI technology in clinical pathological diagnosis, elaborates on its application value, analyzes the current application status, and proposes corresponding application countermeasures, aiming to provide reference for the standardized and popularized development of this technology in clinical pathological diagnosis.
文摘Defence Technology(ISSN 2214-9147(O);2096-3459(P)),sponsored by China Ordnance Society,is published monthly and aims to become one of the well-known comprehensive journals in the world,which reports on the breakthroughs in defence technology by building up an international academic exchange platform for the defence technology related research.It publishes original research papers having direct bearing on defence,with a balanced coverage on analytical,experimental,numerical simulation and applied investigations.It covers various disciplines of science,technology and engineering.
基金supported by the National Natural Science Foundation of China(Nos.52105330,52175307)the Natural Science Foundation of Shandong Province,China(No.ZR2023JQ021)。
文摘The Sn−2Al filler metal was utilized to bond W90 tungsten heavy alloys by the ultrasonic-assisted coating technology in atmospheric environment at 250℃.The effects of ultrasonic power and ultrasonic time on microstructure and interfacial strength of Sn−2Al/W90 interface were investigated.The ultrasound improved the wettability of Sn−2Al filler metal on W90 surface.As the ultrasonic power increased and ultrasonic time increased,the size of Al phase in seam decreased.The maximum value of Sn−2Al/W90 interfacial strength reached 30.1 MPa.Based on the acoustic pressure simulation and bubble dynamics,the intensity of cavitation effect was proportional to ultrasonic power.The generated high temperature and high pressure by cavitation effect reached 83799.6 K and 1.26×10^(14) Pa,respectively.
基金supported by the National Natural Science Foundation of China(Grant Nos.U23A20671 and 12302344)the Creative Groups of Natural Science Foundation of Hubei Province,China(Grant No.2021CFA030).
文摘In recent years,microfluidic technology has emerged as a powerful and innovative tool,attracting significant attention for its ability to provide real-time visualization of CO_(2)flow,mass transfer,and reaction processes in porous media.This review examines the application of microfluidic technology in CO_(2)sequestration in saline aquifers,emphasizing the advantages of saline aquifer for geological sequestration,including safety,high storage capacity,stability,and cost-effectiveness.The materials used for microfluidic chips and the design of microchannels are systematically reviewed,offering forward-looking recommendations for chip selection and microchannel characterization in future research on CO_(2)sequestration in saline aquifer.Based on a detailed analysis of advancements in microfluidic technology,this review highlights key findings related to CO_(2)trapping mechanisms,salt precipitation,and CO_(2)-water-rock chemical interactions within saline aquifers.Although microfluidic technology shows great promise in these areas,this review identifies limitations in current studies and outlines future research directions,aiming to promote further innovation and broader application of microfluidic technology in the field of CO_(2)sequestration in saline aquifer.
基金supported by grants from the National Key R&D Program of China,No.2017YFC0909200(to DC)the National Natural Science Foundation of China,No.62075225(to HZ)+1 种基金Zhejiang Provincial Medical Health Science and Technology Project,No.2023XY053(to ZP)Zhejiang Provincial Traditional Chinese Medical Science and Technology Project,No.2023ZL703(to ZP).
文摘Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biotechnology and its applications in the field of neuropsychiatry.Available evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin deficit.In vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric diseases.Although the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic applications.However,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical applications.This review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.
