Antibacterial action of 4-[p-acetylamino benzenesulfonamido] selenomorpholine (SeB) was studied by microcalorimetry with an LKB-2277 Bioactivity Moni-tor. It was found that SeB had the capacity to inhibit the metaboli...Antibacterial action of 4-[p-acetylamino benzenesulfonamido] selenomorpholine (SeB) was studied by microcalorimetry with an LKB-2277 Bioactivity Moni-tor. It was found that SeB had the capacity to inhibit the metabolic growth of Escherichia coli. But in different sol-vent, the extent of inhibition is different. Removing the effect of solvent, we obtained the half-inhibition conce.ntra-tion(IC50) of SeB from the power-time curves. The value of IC50 of SeB was 1319μg ·mL-1.展开更多
b Department of Chemistry, Wuhan University, Wuhan, Hubei 430072, China The action of β ( N selenomorpholine) ethyl phenyl ketone hydrochloride and 4 ( N selenomorpholine) 2 butanone hydro chl...b Department of Chemistry, Wuhan University, Wuhan, Hubei 430072, China The action of β ( N selenomorpholine) ethyl phenyl ketone hydrochloride and 4 ( N selenomorpholine) 2 butanone hydro chloride on Escherichia coli and Staphylococcus aureus was studied by microcalorimetry. Differences in their capacities to affect the metabolism of this bacterium were observed. The kinetics shows that the selenomorpholine compounds had action on the metabolism process of Escherichia coli and Staphylococcus aureus. The rate constant ( k ) of the studied bacterium in the presence of the drugs are concentration dependant. The growth rate constants decrease with an increase in the mass of the selenomorpholine compounds, but their relationship is different. As deduced from the rate constant ( k ) of the studied bacterium (in log phase) and the half inhibitory concentration (IC 50 ), the experimental results reveal that the studied selenomorpholine compounds all have good antibiotic activity and better antibacterial activity on Staphylococcus aureus than on Escherichia coli.展开更多
In a search for novel agrochemical with high activity and low toxicity,a series of substituted 4,5 -dihydro-imidazol-5-one containing selenomorpholine group were synthesized by a three-step synthetic route starting ...In a search for novel agrochemical with high activity and low toxicity,a series of substituted 4,5 -dihydro-imidazol-5-one containing selenomorpholine group were synthesized by a three-step synthetic route starting from 2-azido-3-aryl-acrylic acid ethyl ester. The structures of title compounds were confirmed by 1H NMR ,IR,mass spectroscopy and elemental analysis. The preliminary bioassay against Gibberella zeae,Fusarium oxysporum,Pellicularia sasakii,Physalospora piricola and Cercospora beticola indicated that most title compounds displayed fungicidal activity at the concentration of 50 ppm and compounds 4l,4n,4o were found to have particularly high activities against Physalospora piricola. A further in vivo test showed that compounds 4l,4n and 4o possessed better fungicidal activity against Physalospora piricola at a concentration of 100 ppm than Carbendazim. To our knowledge,this is first report that 4,5 -dihydro-imidazol-5-one containing selenomorpholine group display fungicidal activity against Physalospora piricola.展开更多
文摘Antibacterial action of 4-[p-acetylamino benzenesulfonamido] selenomorpholine (SeB) was studied by microcalorimetry with an LKB-2277 Bioactivity Moni-tor. It was found that SeB had the capacity to inhibit the metabolic growth of Escherichia coli. But in different sol-vent, the extent of inhibition is different. Removing the effect of solvent, we obtained the half-inhibition conce.ntra-tion(IC50) of SeB from the power-time curves. The value of IC50 of SeB was 1319μg ·mL-1.
文摘b Department of Chemistry, Wuhan University, Wuhan, Hubei 430072, China The action of β ( N selenomorpholine) ethyl phenyl ketone hydrochloride and 4 ( N selenomorpholine) 2 butanone hydro chloride on Escherichia coli and Staphylococcus aureus was studied by microcalorimetry. Differences in their capacities to affect the metabolism of this bacterium were observed. The kinetics shows that the selenomorpholine compounds had action on the metabolism process of Escherichia coli and Staphylococcus aureus. The rate constant ( k ) of the studied bacterium in the presence of the drugs are concentration dependant. The growth rate constants decrease with an increase in the mass of the selenomorpholine compounds, but their relationship is different. As deduced from the rate constant ( k ) of the studied bacterium (in log phase) and the half inhibitory concentration (IC 50 ), the experimental results reveal that the studied selenomorpholine compounds all have good antibiotic activity and better antibacterial activity on Staphylococcus aureus than on Escherichia coli.
文摘In a search for novel agrochemical with high activity and low toxicity,a series of substituted 4,5 -dihydro-imidazol-5-one containing selenomorpholine group were synthesized by a three-step synthetic route starting from 2-azido-3-aryl-acrylic acid ethyl ester. The structures of title compounds were confirmed by 1H NMR ,IR,mass spectroscopy and elemental analysis. The preliminary bioassay against Gibberella zeae,Fusarium oxysporum,Pellicularia sasakii,Physalospora piricola and Cercospora beticola indicated that most title compounds displayed fungicidal activity at the concentration of 50 ppm and compounds 4l,4n,4o were found to have particularly high activities against Physalospora piricola. A further in vivo test showed that compounds 4l,4n and 4o possessed better fungicidal activity against Physalospora piricola at a concentration of 100 ppm than Carbendazim. To our knowledge,this is first report that 4,5 -dihydro-imidazol-5-one containing selenomorpholine group display fungicidal activity against Physalospora piricola.
