Different reaction conditions may cause different reaction paths for cleavage of the Se-Se bonds.Further reactions of(PhSe)2 with methylenecyclopropanes(MCPs)under different conditions lead to the construction of tota...Different reaction conditions may cause different reaction paths for cleavage of the Se-Se bonds.Further reactions of(PhSe)2 with methylenecyclopropanes(MCPs)under different conditions lead to the construction of totally different organic skeletons.Example described herein is typical for students to understand the cleavages of chemical bonds as well as the differences between free radical additions and electrophilic additions.展开更多
The development of artificial enzyme mimics has been rapidly growing in recent years, and it is attracting increasing attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general...The development of artificial enzyme mimics has been rapidly growing in recent years, and it is attracting increasing attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate efficient glutathione peroxidase （GPx） mimics by grafting selenium-containing molecules （phenylselenylbromide, PhSeBr） to a Zr（W）-based UiO-66-NH2 framework. In the presence of glutathione （GSH） serving as substrate, the fabricated UiO-66-Se catalysts can catalyze the reduction of hydroperoxides. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. These high-efficiency GPx mimic metal-organic frameworks （MOFs） are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.展开更多
文摘Different reaction conditions may cause different reaction paths for cleavage of the Se-Se bonds.Further reactions of(PhSe)2 with methylenecyclopropanes(MCPs)under different conditions lead to the construction of totally different organic skeletons.Example described herein is typical for students to understand the cleavages of chemical bonds as well as the differences between free radical additions and electrophilic additions.
基金The project was supported by the National Natural Science Foundation of China for Distinguished Young Scholars （Nos. 21425416 and 21625401）, the Foundation for Innovative Research Groups of the National Natural Science Foundation of China （No. 21421064）, the National Natural Science Foundation of China （Nos. 21574065, 21504043 and 21604038）, the Jiangsu Provincial Founds for Distinguished Young Scholars （No. BK20140044） and NSF （No. BK20160975）, the Program for Outstanding Young Scholars from the Organization Department of the CPC Central Committee, and the National Key Basic Research Program of China （Nos. 2013CB834502 and 2015CB932200）.
文摘The development of artificial enzyme mimics has been rapidly growing in recent years, and it is attracting increasing attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate efficient glutathione peroxidase （GPx） mimics by grafting selenium-containing molecules （phenylselenylbromide, PhSeBr） to a Zr（W）-based UiO-66-NH2 framework. In the presence of glutathione （GSH） serving as substrate, the fabricated UiO-66-Se catalysts can catalyze the reduction of hydroperoxides. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. These high-efficiency GPx mimic metal-organic frameworks （MOFs） are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.
